Rac family small GTPase 3
type: ProteinReference
xref: uniprot F6THF0 345
xref: PTHR24072:SF301
organism: Monodelphis domestica

uniprot E2R2N2 48
type: UnificationXref
id: E2R2N2
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E1BS97 228
xref: PTHR48015:SF22
organism: Gallus gallus

uniprot F6XSJ9 346
type: UnificationXref
id: F6XSJ9
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot F6SZ66 457
organism: Monodelphis domestica

uniprot P01116 145
type: UnificationXref
id: P01116
db: uniprot

uniprot P47809 425
type: UnificationXref
id: P47809
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot A0A452DI16 270
organism: Bos taurus

MAPKAP
type: ProteinReference
xref: P04564
standard name: Mitogen activated protein kinase activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.MAPKAP
comment: ENTITY_REFERENCE_NOTES= Long Name: Mitogen activated protein kinase activated protein kinase Synonym: MK Accession: P04564
member entity reference: Mitogen-activated protein kinase-activated protein kinase 2
member entity reference: MAP kinase-activated protein kinase 3
member entity reference: MAPKAPK2 isoform 1
member entity reference: MAP kinase-activated protein kinase 2
member entity reference: MAPKAPK3 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase-activated protein kinase 2a

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r17 667
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

uniprot A0A2I3TPM9 12
type: UnificationXref
id: A0A2I3TPM9
db: uniprot

PARTICIPANT STOICHIOMETRY r17 668
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

MKK3/6
type: ProteinReference
xref: P04568
standard name: Mitogen-activated protein kinase kinase 3 and 6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Mitogen activated protein kinase kinase 3/6 Synonym: MAPKK3/6,MKK3/6 Accession: P04568
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.MKK3/6
member entity reference: Mitogen-activated protein kinase kinase 6
member entity reference: Dual specificity mitogen-activated protein kinase kinase 6
member entity reference: Mitogen-activated protein kinase kinase 3
member entity reference: Dual specificity mitogen-activated protein kinase kinase 3
member entity reference: Uncharacterized protein
member entity reference: Map2k3 protein

uniprot A0A2I3S4I6 614
type: UnificationXref
id: A0A2I3S4I6
db: uniprot

uniprot A0A1D5QL06 8
type: UnificationXref
id: A0A1D5QL06
db: uniprot

ncbitaxon 9258 28
type: UnificationXref
id: 9258
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re55 675
type: Stoichiometry
physical entity: Growth factor
stoichiometric coefficient: 1.0

uniprot Q28BZ0 528
type: UnificationXref
id: Q28BZ0
db: uniprot

PARTICIPANT STOICHIOMETRY re55 676
type: Stoichiometry
physical entity: Growth factor receptor
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re55 677
type: Stoichiometry
physical entity: Complex (Growth Factor Receptor/Growth Factor)
stoichiometric coefficient: 1.0

uniprot F7GAP5 467
type: UnificationXref
id: F7GAP5
db: uniprot

PARTICIPANT STOICHIOMETRY r66 709
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 708
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 1.0

Mus musculus
type: BioSource
xref: ncbitaxon 10090 37

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P28482 58
organism: Homo sapiens

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: uniprot Q16644 410
xref: PTHR24349:SF64
organism: Homo sapiens

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot P49071 407
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 49
organism: Canis lupus familiaris

Ras Pathway
type: Pathway
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r15
pathway component: STATE_TRANSITION_LEFT__TAK-RIGHT__TAK-_r23
pathway component: STATE_TRANSITION_LEFT__MLK3-RIGHT__MLK3-_r24
pathway component: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_r62
pathway component: STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_r17
pathway component: STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r18
pathway component: STATE_TRANSITION_LEFT__Sec5-RIGHT__Sec5-_r28
pathway component: STATE_TRANSITION_LEFT__p38-RIGHT__p38-_r37
pathway component: STATE_TRANSITION_LEFT__MKK3_6-RIGHT__MKK3_6-_r36
pathway component: STATE_TRANSITION_LEFT__AP1-RIGHT__AP1-_r63
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r21
pathway component: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r16
pathway component: STATE_TRANSITION_LEFT__Pip2-RIGHT__Pip3-_re56
pathway component: STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r43
pathway component: STATE_TRANSITION_LEFT__RalBP1-RIGHT__RalBP1-_r27
pathway component: HETERODIMER_ASSOCIATION_LEFT__SOS-_Shc-_Grb2-RIGHT__Complex__Shc_Grb2__SOS_-_r11
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r32
pathway component: STATE_TRANSITION_LEFT__RalGDS-RIGHT__RalGDS-_r4
pathway component: STATE_TRANSITION_LEFT__GTP-_Ral-RIGHT__GDP-_Ral-_r14
pathway component: STATE_TRANSITION_LEFT__GSK3-RIGHT__GSK3-_r35
pathway component: STATE_TRANSITION_LEFT__PLD-RIGHT__PLD-_r29
pathway component: STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r20
pathway component: STATE_TRANSITION_LEFT__ATF2-RIGHT__ATF2-_r66
pathway component: STATE_TRANSITION_LEFT__Elk_1-RIGHT__Elk_1-_r45
pathway component: STATE_TRANSITION_LEFT__MEKK1_4-RIGHT__MEKK1_4-_r13
pathway component: STATE_TRANSITION_LEFT__MAPKAP-RIGHT__MAPKAP-_r30
pathway component: STATE_TRANSITION_LEFT__p90RSK-RIGHT__p90RSK-_r25
pathway component: HETERODIMER_ASSOCIATION_LEFT__Growth_factor-_Growth_factor_receptor-RIGHT__Complex__Growth_Factor_Receptor_Growth_Factor_-_re55
pathway component: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r22
pathway component: STATE_TRANSITION_LEFT__Tiam1-RIGHT__Tiam1-_r5
pathway component: STATE_TRANSITION_LEFT__Stat_1_3-RIGHT__Stat_1_3-_r64
pathway component: STATE_TRANSITION_LEFT__Ras-_GTP-RIGHT__GDP-_Ras-_r1
pathway component: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r34
pathway component: STATE_TRANSITION_LEFT__PDK-RIGHT__PDK-_r33
pathway component: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r3
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r31
pathway component: STATE_TRANSITION_LEFT__MKK4_7-RIGHT__MKK4_7-_r19
pathway component: UNKNOWN_TRANSITION_LEFT__Ras-RIGHT__p14_19_ARF-_re66
xref: PANTHER Pathway P04393 1
comment: MODEL_NOTES=Panther Pathway: P04393 Cell proliferation is tightly regulated by exposure to serum, growth factors, survival factors and other cues from the cellular environment. The Ras signaling pathway plays an important role in transducing these extracellular cues, and stimulating cellular proliferation, differentiation and survival. Activating mutations in the Ras gene are frequently found in human cancers, leading to constitutive signaling throught the pathway and unregulated cell proliferation and survival. Medline=15519853 Medline=9685325 PMID: 15519853 PMID: 9685325

PTHR24072:SF309
type: RelationshipXref
id: PTHR24072:SF309
db: PANTHER Family
relationship type: By Homology

uniprot Q9QUI0 646
type: UnificationXref
id: Q9QUI0
db: uniprot

RalGDS
type: Protein
entity reference: RalGDS
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

uniprot E2RCV1 452
type: UnificationXref
id: E2RCV1
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q8NEB9 486
organism: Homo sapiens

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F1Q118 213
organism: Canis lupus familiaris

PTHR24072:SF300
type: RelationshipXref
id: PTHR24072:SF300
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 57
organism: Homo sapiens

MAPKAP
type: Protein
entity reference: MAPKAP
feature: MAPKAP s60 a82 rs3
feature: ACTIVE 45
feature: MAPKAP s60 a82 rs1
feature: MAPKAP s60 a82 rs2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Rho-related GTP-binding protein RhoA-A
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q6NUX8 641
organism: Danio rerio

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: uniprot A0A2I3TN41 252
xref: PTHR24356:SF163
organism: Pan troglodytes

NRAS protein
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot A5D7R9 129
organism: Bos taurus

PTHR24351:SF213
type: RelationshipXref
id: PTHR24351:SF213
db: PANTHER Family
relationship type: By Homology

Phospholipase
type: ProteinReference
xref: uniprot J9P1D8 594
xref: PTHR18896:SF57
organism: Canis lupus familiaris

uniprot E9I1I7 133
type: UnificationXref
id: E9I1I7
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q01986 300
organism: Rattus norvegicus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot F7FRY0 32
organism: Monodelphis domestica

uniprot F7GLY8 500
type: UnificationXref
id: F7GLY8
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot O42376 322
xref: PTHR24055:SF146
organism: Danio rerio

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q9Z1L0 489
xref: PTHR10048:SF33
organism: Rattus norvegicus

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P79737 151
organism: Danio rerio

uniprot P18265 114
type: UnificationXref
id: P18265
db: uniprot

uniprot Q5ZIF0 304
type: UnificationXref
id: Q5ZIF0
db: uniprot

PARTICIPANT STOICHIOMETRY re56 670
type: Stoichiometry
physical entity: Pip3
stoichiometric coefficient: 1.0

uniprot F7FHD1 53
type: UnificationXref
id: F7FHD1
db: uniprot

uniprot F6V332 314
type: UnificationXref
id: F6V332
db: uniprot

uniprot Q5RKN6 85
type: UnificationXref
id: Q5RKN6
db: uniprot

uniprot F6QP11 541
type: UnificationXref
id: F6QP11
db: uniprot

Map2k3 protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot B1H230 493
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re56 669
type: Stoichiometry
physical entity: Pip2
stoichiometric coefficient: 1.0

JNK s43 a68 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__Ras-_GTP-RIGHT__GDP-_Ras-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 693
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 694
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 692
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 695
left: Ras
left: GTP
interaction type: STATE_TRANSITION
right: GDP
right: Ras

Ras protein let-60
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P22981 149
organism: Caenorhabditis elegans

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P41969 590
organism: Mus musculus

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F1NYZ2 292
organism: Gallus gallus

Rac family small GTPase 3a
type: ProteinReference
xref: uniprot Q6DGB7 365
xref: PTHR24072:SF301
organism: Danio rerio

uniprot Q28GJ8 634
type: UnificationXref
id: Q28GJ8
db: uniprot

uniprot A0A1D5QKD3 290
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

uniprot P22981 149
type: UnificationXref
id: P22981
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLD-RIGHT__PLD-_r29
controller: Ral

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot F7H7W3 33
organism: Macaca mulatta

GTP
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot F1PHV7 135
organism: Canis lupus familiaris

uniprot F6WB97 175
type: UnificationXref
id: F6WB97
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q2TY19 563
organism: Gallus gallus

STATE_TRANSITION_LEFT__MKK4_7-RIGHT__MKK4_7-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 663
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 664
left: MKK4/7
interaction type: STATE_TRANSITION
right: MKK4/7

uniprot P05627 378
type: UnificationXref
id: P05627
db: uniprot

NRAS isoform 1
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot H2PZQ7 142
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E7EXT6 538
xref: PTHR24356:SF190
organism: Danio rerio

uniprot F6YAB9 315
type: UnificationXref
id: F6YAB9
db: uniprot

Protein CBR-RHO-1
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot A8XIF5 615
organism: Caenorhabditis briggsae

uniprot P79737 151
type: UnificationXref
id: P79737
db: uniprot

uniprot P61585 627
type: UnificationXref
id: P61585
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7DUD6 463
organism: Ornithorhynchus anatinus

MKK3/6
type: Protein
entity reference: MKK3/6
feature: MKK3 6 s66 a96 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot A0A3Q1MNG1 492
organism: Bos taurus

uniprot F7FRY0 32
type: UnificationXref
id: F7FRY0
db: uniprot

ncbitaxon 7165 161
type: UnificationXref
id: 7165
db: ncbitaxon

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 331
xref: PTHR24055:SF110
organism: Pan troglodytes

uniprot Q66II3 87
type: UnificationXref
id: Q66II3
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7CU42 237
xref: PTHR48015:SF22
organism: Monodelphis domestica

ncbitaxon 284811 534
type: UnificationXref
id: 284811
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r34 710
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 541
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r34 711
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

uniprot P27577 397
type: UnificationXref
id: P27577
db: uniprot

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot E2RL20 272
organism: Canis lupus familiaris

uniprot E9HL06 618
type: UnificationXref
id: E9HL06
db: uniprot

Novel Rho protein
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q28HZ4 635
organism: Xenopus tropicalis

uniprot P54673 480
type: UnificationXref
id: P54673
db: uniprot

uniprot Q04982 286
type: UnificationXref
id: Q04982
db: uniprot

Rho
type: ProteinReference
xref: P04578
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Rho
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Rho Synonym: Synonym not specified Accession: P04578
member entity reference: Rho-related GTP-binding protein RhoA-B
member entity reference: Transforming protein RhoA
member entity reference: Protein CBR-RHO-1
member entity reference: Ras homolog family member B
member entity reference: GTP-binding protein
member entity reference: Uncharacterized protein
member entity reference: Rho-related GTP-binding protein RhoB
member entity reference: Ras homolog family member C
member entity reference: Ras homolog family member Ca
member entity reference: Rho-related GTP-binding protein RhoA-C
member entity reference: Rho-related GTP-binding protein RhoC
member entity reference: Ras-like GTP-binding protein rhoA
member entity reference: Novel Rho protein
member entity reference: RHOA isoform 2
member entity reference: Rho-related GTP-binding protein RhoA-A
member entity reference: Rho-related GTP-binding protein RhoA-D
member entity reference: Ras homolog family member A

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 63
organism: Mus musculus

Si:dkeyp-80c12.7
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot B8JIQ1 107
organism: Danio rerio

Rho-related protein racB
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34148 351
organism: Dictyostelium discoideum

uniprot H2QKY3 556
type: UnificationXref
id: H2QKY3
db: uniprot

uniprot Q62159 638
type: UnificationXref
id: Q62159
db: uniprot

uniprot F7CQI0 403
type: UnificationXref
id: F7CQI0
db: uniprot

MAPKAPK3 isoform 1
type: ProteinReference
xref: uniprot H2QMP5 406
xref: PTHR24349:SF64
organism: Pan troglodytes

uniprot A5PJP8 417
type: UnificationXref
id: A5PJP8
db: uniprot

uniprot F6ZM17 31
type: UnificationXref
id: F6ZM17
db: uniprot

uniprot Q7YQL4 250
type: UnificationXref
id: Q7YQL4
db: uniprot

Exocyst complex component 2
type: ProteinReference
xref: uniprot H2QS72 95
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E1C3P6 229
xref: PTHR48015:SF20
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AP1-RIGHT__AP1-_r63
controller: p90RSK

uniprot Q15418 42
type: UnificationXref
id: Q15418
db: uniprot

p90RSK s55 a78 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.8069631906872994

uniprot A0A2I3RDV4 164
type: UnificationXref
id: A0A2I3RDV4
db: uniprot

uniprot Q52WY2 529
type: UnificationXref
id: Q52WY2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_r17
controller: Rac

uniprot P62994 83
type: UnificationXref
id: P62994
db: uniprot

uniprot F6SZ66 457
type: UnificationXref
id: F6SZ66
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F7BWW9 217
organism: Ornithorhynchus anatinus

Stat 1 3 s78 a109 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MODULATION
type: RelationshipTypeVocabulary

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

Stat 1/3
type: ProteinReference
xref: P04566
standard name: Signal transducers and activators of transcription
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Signal transducer and activator of transcription Synonym: STAT Accession: P04566
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Stat 1/3
member entity reference: Signal transducer and activator of transcription
member entity reference: Signal transducer and activator of transcription 3
member entity reference: Signal transducer and activator of transcription 1-alpha/beta
member entity reference: Signal transducer and activator of transcription 1

uniprot F6URW3 215
type: UnificationXref
id: F6URW3
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot F7FDA0 465
type: UnificationXref
id: F7FDA0
db: uniprot

uniprot B1H230 493
type: UnificationXref
id: B1H230
db: uniprot

uniprot P60953 526
type: UnificationXref
id: P60953
db: uniprot

STATE_TRANSITION_LEFT__MKK3_6-RIGHT__MKK3_6-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 705
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 704
left: MKK3/6
interaction type: STATE_TRANSITION
right: MKK3/6

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 55
organism: Pan troglodytes

uniprot F7ES59 621
type: UnificationXref
id: F7ES59
db: uniprot

Ral guanine nucleotide dissociation stimulator
type: ProteinReference
xref: uniprot Q12967 204
xref: PTHR23113:SF35
organism: Homo sapiens

ERK s51 a72 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Growth factor receptor-bound protein 2
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q60631 86
organism: Mus musculus

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot Q9JM73 389
organism: Mus musculus

uniprot F1MYM3 454
type: UnificationXref
id: F1MYM3
db: uniprot

uniprot G3X793 318
type: UnificationXref
id: G3X793
db: uniprot

uniprot Q04970 152
type: UnificationXref
id: Q04970
db: uniprot

uniprot Q5F337 363
type: UnificationXref
id: Q5F337
db: uniprot

uniprot H2Q104 405
type: UnificationXref
id: H2Q104
db: uniprot

AP1
type: ProteinReference
xref: P04560
standard name: activator protein-1
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.AP1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: AP1 Synonym: Synonym not specified Accession: P04560
member entity reference: Transcription factor AP-1
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit

uniprot Q7T383 189
type: UnificationXref
id: Q7T383
db: uniprot

Growth factor
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa5 662
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G4D2 386
xref: PTHR48019:SF40
organism: Macaca mulatta

uniprot O88763 474
type: UnificationXref
id: O88763
db: uniprot

p90RSK s55 a78 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.5057941403632875

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot A0A3Q2UBK0 17
organism: Gallus gallus

Cell division control protein 42 homolog isoform 2
type: ProteinReference
xref: uniprot F6RBZ7 517
xref: PTHR24072:SF337
organism: Macaca mulatta

uniprot A0A3Q1LJJ3 392
type: UnificationXref
id: A0A3Q1LJJ3
db: uniprot

uniprot A0A0G2K9U9 609
type: UnificationXref
id: A0A0G2K9U9
db: uniprot

PTHR48015:SF30
type: RelationshipXref
id: PTHR48015:SF30
db: PANTHER Family
relationship type: By Homology

uniprot Q7PKD8 188
type: UnificationXref
id: Q7PKD8
db: uniprot

uniprot O15530 254
type: UnificationXref
id: O15530
db: uniprot

uniprot F7EH19 51
type: UnificationXref
id: F7EH19
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6YAB9 315
organism: Monodelphis domestica

PTHR44329:SF55
type: RelationshipXref
id: PTHR44329:SF55
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RalBP1-RIGHT__RalBP1-_r27
controller: Ral

PARTICIPANT STOICHIOMETRY r22 740
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

uniprot F7CS91 619
type: UnificationXref
id: F7CS91
db: uniprot

PARTICIPANT STOICHIOMETRY r22 741
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

T-lymphoma invasion and metastasis-inducing protein 1
type: ProteinReference
xref: PTHR46001:SF1
xref: uniprot Q60610 558
organism: Mus musculus

p90RSK s55 a78 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.6894200745829581

ncbitaxon 8364 24
type: UnificationXref
id: 8364
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot F6XT65 294
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot H2QS62 574
organism: Pan troglodytes

uniprot F6XUP1 235
type: UnificationXref
id: F6XUP1
db: uniprot

T-cell lymphoma invasion and metastasis 1
type: ProteinReference
xref: PTHR46001:SF1
xref: uniprot D3ZWV8 553
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r30 723
type: Stoichiometry
physical entity: MAPKAP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r18
controller: Rac

ncbitaxon 6669 134
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot F7BFL2 402
type: UnificationXref
id: F7BFL2
db: uniprot

AKT
type: Protein
entity reference: AKT
feature: AKT s64 a92 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot H2R0G7 575
type: UnificationXref
id: H2R0G7
db: uniprot

PTHR44329:SF47
type: RelationshipXref
id: PTHR44329:SF47
db: PANTHER Family
relationship type: By Homology

uniprot F1P2A7 91
type: UnificationXref
id: F1P2A7
db: uniprot

PARTICIPANT STOICHIOMETRY r30 722
type: Stoichiometry
physical entity: MAPKAP
stoichiometric coefficient: 1.0

Ras-like protein
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot Q12526 153
organism: Emericella nidulans

AKT
type: Protein
entity reference: AKT
feature: AKT s104 a93 rs1
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A4FV00 564
organism: Bos taurus

Glycogen synthase kinase 3
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot Q9YH60 124
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR23113:SF213
xref: uniprot F6TVC3 195
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7CYE3 572
xref: PTHR24055:SF162
organism: Xenopus tropicalis

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7G800 238
xref: PTHR48015:SF30
organism: Monodelphis domestica

MEKK1/4
type: Protein
entity reference: MEKK1/4
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot P15336 169
organism: Homo sapiens

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q5RKN6 85
organism: Danio rerio

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot A0A2I3RB56 491
organism: Pan troglodytes

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot P46734 502
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r27 730
type: Stoichiometry
physical entity: RalBP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r27 731
type: Stoichiometry
physical entity: RalBP1
stoichiometric coefficient: 1.0

uniprot Q0VCY4 203
type: UnificationXref
id: Q0VCY4
db: uniprot

MAP3K7 C-terminal-like
type: ProteinReference
xref: uniprot A0A0G2K9U9 609
organism: Rattus norvegicus

uniprot Q43007 603
type: UnificationXref
id: Q43007
db: uniprot

Serum response factor
type: ProteinReference
xref: uniprot E1BJP4 382
xref: PTHR48019:SF40
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot A0A3Q2U4X3 536
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Stat_1_3-RIGHT__Stat_1_3-_r64
controller: p38

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZTS0 316
xref: PTHR24055:SF146
organism: Macaca mulatta

GSK3
type: ProteinReference
xref: P04546
standard name: Glycogen synthase kinase 3
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.GSK3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Glycogen synthase kinase 3 Synonym: GSK3 Accession: P04546
member entity reference: Glycogen synthase kinase-3 beta
member entity reference: Glycogen synthase kinase 3
member entity reference: Glycogen synthase kinase-3 alpha
member entity reference: Glycogen synthase kinase-3 beta isoform 1
member entity reference: Uncharacterized protein
member entity reference: Si:dkeyp-80c12.7
member entity reference: Glycogen synthase kinase
member entity reference: Glycogen synthase kinase 3 alpha
member entity reference: Glycogen synthase kinase-3
member entity reference: Glycogen synthase kinase 3 beta

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

T cell lymphoma invasion and metastasis 1
type: ProteinReference
xref: PTHR46001:SF1
xref: uniprot E2R0M7 554
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot F7HPR8 647
organism: Macaca mulatta

uniprot P49840 116
type: UnificationXref
id: P49840
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot Q6RUV5 370
xref: PTHR24072:SF105
organism: Rattus norvegicus

uniprot B3DM35 393
type: UnificationXref
id: B3DM35
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A1D5QE27 444
organism: Macaca mulatta

uniprot H2QP14 240
type: UnificationXref
id: H2QP14
db: uniprot

PARTICIPANT STOICHIOMETRY r33 713
type: Stoichiometry
physical entity: PDK
stoichiometric coefficient: 1.0

uniprot Q95ME4 163
type: UnificationXref
id: Q95ME4
db: uniprot

Stat 1 3 s91 a113 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K5T3 443
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot E9GYE9 516
organism: Daphnia pulex

PARTICIPANT STOICHIOMETRY r33 712
type: Stoichiometry
physical entity: PDK
stoichiometric coefficient: 1.0

uniprot O08911 320
type: UnificationXref
id: O08911
db: uniprot

V-ral simian leukemia viral oncogene homolog Ba (ras-related)
type: ProteinReference
xref: PTHR24070:SF199
xref: uniprot Q6DC92 187
organism: Danio rerio

uniprot O15211 200
type: UnificationXref
id: O15211
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AP1-RIGHT__AP1-_r63
controller: JNK

uniprot F7HHY8 404
type: UnificationXref
id: F7HHY8
db: uniprot

uniprot F1M7N7 22
type: UnificationXref
id: F1M7N7
db: uniprot

Phospholipase D1
type: ProteinReference
xref: PTHR18896:SF57
xref: uniprot Q9Z280 608
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 52
organism: Monodelphis domestica

Rac family small GTPase 1b
type: ProteinReference
xref: uniprot Q29RC5 360
xref: PTHR24072:SF105
organism: Danio rerio

Mitogen-activated protein kinase p38b
type: ProteinReference
xref: uniprot O61443 323
xref: PTHR24055:SF238
organism: Drosophila melanogaster

uniprot P41156 398
type: UnificationXref
id: P41156
db: uniprot

Ras-like GTP-binding protein rhoA
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot Q22038 633
organism: Caenorhabditis elegans

ncbitaxon 9606 40
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot K7BYT0 296
type: UnificationXref
id: K7BYT0
db: uniprot

Phospholipase D2
type: ProteinReference
xref: uniprot O14939 596
xref: PTHR18896:SF121
organism: Homo sapiens

Exocyst complex component 2
type: ProteinReference
xref: uniprot Q9D4H1 101
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F7GEK1 545
organism: Monodelphis domestica

p90RSK s56 a81 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.8069631906872994

uniprot O14733 423
type: UnificationXref
id: O14733
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Survival
controller: AP1

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Proliferation
controller: PLD

uniprot Q28IJ0 636
type: UnificationXref
id: Q28IJ0
db: uniprot

uniprot Q5RGD7 99
type: UnificationXref
id: Q5RGD7
db: uniprot

uniprot F7H9J1 73
type: UnificationXref
id: F7H9J1
db: uniprot

uniprot F6UNV6 25
type: UnificationXref
id: F6UNV6
db: uniprot

SRF s108 a115 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Proliferation
controller: Rac

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot Q62829 248
organism: Rattus norvegicus

uniprot E2REH3 230
type: UnificationXref
id: E2REH3
db: uniprot

MKK4/7
type: ProteinReference
xref: P04565
standard name: Mitogen activated protein kinase kinase 4/7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Mitogen activated protein kinase kinase 4/7 Synonym: JNK kinase,JNKK,MKK4,MKK7,SEK1 Accession: P04565
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.MKK4/7
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: Dual specificity mitogen-activated protein kinase kinase 7
member entity reference: Mitogen-activated protein kinase kinase 4
member entity reference: MAP2K4 isoform 3
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase 4A
member entity reference: Mitogen-activated protein kinase kinase 7
member entity reference: MAP2K4 protein

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Proliferation
controller: Rho

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK4_7-RIGHT__MKK4_7-_r19
controller: MEKK1/4

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot E1BMX0 132
organism: Bos taurus

uniprot F6PXH5 496
type: UnificationXref
id: F6PXH5
db: uniprot

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 343

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

uniprot A0A0G2K5T3 443
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F1PXD3 495
organism: Canis lupus familiaris

uniprot F1Q4F8 540
type: UnificationXref
id: F1Q4F8
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9Z1B7 337
organism: Mus musculus

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: uniprot Q3SYZ2 411
xref: PTHR24349:SF64
organism: Bos taurus

p90RSK s56 a81 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.5057941403632875

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6T2E7 233
xref: PTHR48015:SF22
organism: Xenopus tropicalis

uniprot P08642 147
type: UnificationXref
id: P08642
db: uniprot

PTHR11849:SF209
type: RelationshipXref
id: PTHR11849:SF209
db: PANTHER Family
relationship type: By Homology

uniprot F6XT65 294
type: UnificationXref
id: F6XT65
db: uniprot

Evidence 89
type: Evidence
evidence code: ISS
comment: Website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd

uniprot Q9PSX7 645
type: UnificationXref
id: Q9PSX7
db: uniprot

uniprot O77627 376
type: UnificationXref
id: O77627
db: uniprot

uniprot J9P5W6 295
type: UnificationXref
id: J9P5W6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7GWI2 239
xref: PTHR48015:SF22
organism: Macaca mulatta

Growth factor receptor
type: Protein
feature: Growth factor receptor s6 a6 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P32883 150
type: UnificationXref
id: P32883
db: uniprot

PARTICIPANT STOICHIOMETRY r31 721
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 30

PARTICIPANT STOICHIOMETRY r31 720
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: uniprot P16951 170
xref: PTHR19304:SF9
organism: Mus musculus

p90RSK s56 a81 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.6894200745829581

uniprot A0A1D5QUZ8 46
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

uniprot P51812 39
type: UnificationXref
id: P51812
db: uniprot

PARTICIPANT STOICHIOMETRY r3 683
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 682
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O15530 254
organism: Homo sapiens

Ribosomal protein S6 kinase alpha-6
type: ProteinReference
xref: PTHR24351:SF98
xref: uniprot Q9UK32 43
organism: Homo sapiens

uniprot Q60631 86
type: UnificationXref
id: Q60631
db: uniprot

uniprot Q63932 305
type: UnificationXref
id: Q63932
db: uniprot

PTHR48015:SF22
type: RelationshipXref
id: PTHR48015:SF22
db: PANTHER Family
relationship type: By Homology

PTHR48015:SF20
type: RelationshipXref
id: PTHR48015:SF20
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Stat_1_3-RIGHT__Stat_1_3-_r64
controller: ERK

PTHR24072:SF281
type: RelationshipXref
id: PTHR24072:SF281
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6ZKB3 570
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7G3I5 466
organism: Monodelphis domestica

uniprot Q9Z280 608
type: UnificationXref
id: Q9Z280
db: uniprot

uniprot P34148 351
type: UnificationXref
id: P34148
db: uniprot

SHC (Src homology 2 domain containing) transforming protein 1
type: ProteinReference
xref: uniprot H2R8L2 648
xref: PTHR10337:SF2
organism: Pan troglodytes

uniprot E2RB82 431
type: UnificationXref
id: E2RB82
db: uniprot

ncbitaxon 5759 343
type: UnificationXref
id: 5759
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot G3X793 318
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F6WV79 568
organism: Monodelphis domestica

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot A0A3Q1M353 269
organism: Bos taurus

Protein CBR-LET-60
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot A8X0X5 130
organism: Caenorhabditis briggsae

uniprot A0A2I3RZ31 561
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot O08648 75
organism: Mus musculus

AGAP012108-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PKD8 188
organism: Anopheles gambiae

uniprot O75914 241
type: UnificationXref
id: O75914
db: uniprot

PTHR24072:SF287
type: RelationshipXref
id: PTHR24072:SF287
db: PANTHER Family
relationship type: By Homology

uniprot P49137 408
type: UnificationXref
id: P49137
db: uniprot

uniprot Q66JH1 159
type: UnificationXref
id: Q66JH1
db: uniprot

RHOA isoform 2
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot H2QML4 623
organism: Pan troglodytes

uniprot Q9DGD9 586
type: UnificationXref
id: Q9DGD9
db: uniprot

uniprot Q9WV60 123
type: UnificationXref
id: Q9WV60
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 324
xref: PTHR24055:SF110
organism: Mus musculus

Ral
type: Protein
entity reference: Ral
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot G2HGD2 81
type: UnificationXref
id: G2HGD2
db: uniprot

uniprot Q62829 248
type: UnificationXref
id: Q62829
db: uniprot

uniprot Q15349 41
type: UnificationXref
id: Q15349
db: uniprot

uniprot Q63844 63
type: UnificationXref
id: Q63844
db: uniprot

uniprot P17325 379
type: UnificationXref
id: P17325
db: uniprot

uniprot P92208 583
type: UnificationXref
id: P92208
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 263
evidence: Evidence 265
evidence: Evidence 266
evidence: Evidence 264
xref: uniprot A0A2I3THL4 267
xref: PTHR44329:SF22
organism: Pan troglodytes

STATE_TRANSITION_LEFT__PDK-RIGHT__PDK-_r33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 712
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 713
left: PDK
interaction type: STATE_TRANSITION
right: PDK

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 258

Tiam1
type: ProteinReference
xref: P04571
standard name: T-cell lymphoma invasion and metastasis
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Tiam1
comment: ENTITY_REFERENCE_NOTES= Long Name: T-cell lymphoma invasion and metastasis Synonym: T-cell lymphoma invasion and metastasis Accession: P04571
member entity reference: T-lymphoma invasion and metastasis-inducing protein 1
member entity reference: T cell lymphoma invasion and metastasis 1
member entity reference: T-cell lymphoma invasion and metastasis 1

RAS like proto-oncogene B
type: ProteinReference
xref: PTHR24070:SF199
xref: uniprot E2RLB2 174
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r37 703
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 702
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

uniprot Q5A1D3 61
type: UnificationXref
id: Q5A1D3
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7GAP5 467
xref: PTHR10048:SF33
organism: Ornithorhynchus anatinus

uniprot P42338 478
type: UnificationXref
id: P42338
db: uniprot

PTHR18896:SF121
type: RelationshipXref
id: PTHR18896:SF121
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 56
organism: Rattus norvegicus

Stat 1/3
type: Protein
entity reference: Stat 1/3
feature: ACTIVE 45
feature: Stat 1 3 s91 a113 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

…
type: Stoichiometry
physical entity: Growth factor receptor
stoichiometric coefficient: 2.0

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot P47809 425
organism: Mus musculus

uniprot Q6DHE8 639
type: UnificationXref
id: Q6DHE8
db: uniprot

ncbitaxon 9031 5
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot P54674 481
type: UnificationXref
id: P54674
db: uniprot

Ral
type: Protein
entity reference: Ral
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot Q13233 77
xref: PTHR24361:SF414
organism: Homo sapiens

uniprot F1PS09 194
type: UnificationXref
id: F1PS09
db: uniprot

uniprot J9NX28 178
type: UnificationXref
id: J9NX28
db: uniprot

uniprot P63086 60
type: UnificationXref
id: P63086
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RP04 20
xref: PTHR24351:SF58
organism: Canis lupus familiaris

uniprot Q0IIE2 651
type: UnificationXref
id: Q0IIE2
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O00329 472
xref: PTHR10048:SF35
organism: Homo sapiens

uniprot F7BXX1 384
type: UnificationXref
id: F7BXX1
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 65

uniprot Q13177 246
type: UnificationXref
id: Q13177
db: uniprot

uniprot H2RA86 55
type: UnificationXref
id: H2RA86
db: uniprot

AP1 s76 a107 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot Q63538 330
organism: Rattus norvegicus

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot Q00969 171
organism: Rattus norvegicus

uniprot P18652 34
type: UnificationXref
id: P18652
db: uniprot

uniprot F6Z879 420
type: UnificationXref
id: F6Z879
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot F7AKA6 72
organism: Monodelphis domestica

uniprot Q6NVL3 642
type: UnificationXref
id: Q6NVL3
db: uniprot

Novel Rho protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q28IJ0 636
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r11 699
type: Stoichiometry
physical entity: Complex (Shc/Grb2/ SOS)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 698
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

SRF
type: Protein
entity reference: SRF
feature: SRF s77 a108 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 10090 37
type: UnificationXref
id: 10090
db: ncbitaxon

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Proliferation
controller: SRF

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot D4A5Q1 450
organism: Rattus norvegicus

Elk 1 s87 a117 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.8050345804348424
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot P62993 82
type: UnificationXref
id: P62993
db: uniprot

uniprot A0A3Q2TVV5 106
type: UnificationXref
id: A0A3Q2TVV5
db: uniprot

PTHR24072:SF0
type: RelationshipXref
id: PTHR24072:SF0
db: PANTHER Family
relationship type: By Homology

UNKNOWN_TRANSITION_LEFT__Ras-RIGHT__p14_19_ARF-_re66
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re66 733
participant stoichiometry: PARTICIPANT STOICHIOMETRY re66 732
left: Ras
interaction type: UNKNOWN_TRANSITION
right: p14/19 ARF

MKK4 7 s41 a64 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q62925 78
type: UnificationXref
id: Q62925
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A2I3TRY9 446
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re66 732
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re66 733
type: Stoichiometry
physical entity: p14/19 ARF
stoichiometric coefficient: 1.0

Serum response factor
type: ProteinReference
xref: uniprot D3ZHH8 381
xref: PTHR48019:SF40
organism: Rattus norvegicus

Pip2
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot P15056 285
organism: Homo sapiens

uniprot P48555 181
type: UnificationXref
id: P48555
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot Q4KSH7 426
xref: PTHR48013:SF17
organism: Rattus norvegicus

Elk 1 s87 a117 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.458697954198361

uniprot Q6P023 64
type: UnificationXref
id: Q6P023
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XP81 544
xref: PTHR24356:SF171
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r11 696
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 697
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

uniprot F1PAE3 109
type: UnificationXref
id: F1PAE3
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F6PXH5 496
organism: Ornithorhynchus anatinus

uniprot F1MAI3 210
type: UnificationXref
id: F1MAI3
db: uniprot

P04542
type: UnificationXref
id: P04542
db: PANTHER Pathway Component

uniprot Q9JHG7 488
type: UnificationXref
id: Q9JHG7
db: uniprot

P04541
type: UnificationXref
id: P04541
db: PANTHER Pathway Component

uniprot Q5M824 652
type: UnificationXref
id: Q5M824
db: uniprot

uniprot H2QLB4 54
type: UnificationXref
id: H2QLB4
db: uniprot

P04546
type: UnificationXref
id: P04546
db: PANTHER Pathway Component

P04545
type: UnificationXref
id: P04545
db: PANTHER Pathway Component

uniprot F7D0A6 421
type: UnificationXref
id: F7D0A6
db: uniprot

P04544
type: UnificationXref
id: P04544
db: PANTHER Pathway Component

Shc
type: Protein
entity reference: Shc
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

P04543
type: UnificationXref
id: P04543
db: PANTHER Pathway Component

uniprot A7SFJ1 508
type: UnificationXref
id: A7SFJ1
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7G8G5 434
xref: PTHR11801:SF2
organism: Macaca mulatta

uniprot F6UWI0 26
type: UnificationXref
id: F6UWI0
db: uniprot

Exocyst complex component 2
type: ProteinReference
xref: uniprot F6R680 92
organism: Ornithorhynchus anatinus

STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 740
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 741
left: ERK
interaction type: STATE_TRANSITION
right: ERK

Stress-activated protein kinase JNK
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot P92208 583
organism: Drosophila melanogaster

uniprot P42337 477
type: UnificationXref
id: P42337
db: uniprot

uniprot F7A567 518
type: UnificationXref
id: F7A567
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 19

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot F6YJ34 29
organism: Monodelphis domestica

Activating transcription factor 2
type: ProteinReference
xref: uniprot F7EVK3 167
xref: PTHR19304:SF9
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r15
controller: Tiam1

uniprot P53779 581
type: UnificationXref
id: P53779
db: uniprot

uniprot D4A3U7 310
type: UnificationXref
id: D4A3U7
db: uniprot

uniprot B3S037 511
type: UnificationXref
id: B3S037
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

ncbitaxon 10228 512
type: UnificationXref
id: 10228
db: ncbitaxon

INHIBITION
type: RelationshipTypeVocabulary

MKK4 7 s40 a63 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r20
controller: MKK4/7

Growth factor receptor-bound protein 2
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q66II3 87
organism: Xenopus tropicalis

uniprot Q6ZHA3 371
type: UnificationXref
id: Q6ZHA3
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot D3Z8E0 18
xref: PTHR24351:SF58
organism: Rattus norvegicus

uniprot P60764 354
type: UnificationXref
id: P60764
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__SOS-_Shc-_Grb2-RIGHT__Complex__Shc_Grb2__SOS_-_r11
controller: Complex (Growth Factor Receptor/Growth Factor)

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: uniprot O93602 168
xref: PTHR19304:SF9
organism: Gallus gallus

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7HLC7 468
xref: PTHR10048:SF35
organism: Macaca mulatta

uniprot E2RSB0 312
type: UnificationXref
id: E2RSB0
db: uniprot

uniprot A0A1D5QLH3 610
type: UnificationXref
id: A0A1D5QLH3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPKAP-RIGHT__MAPKAP-_r30
controller: ERK

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A3Q1LQK4 448
organism: Bos taurus

uniprot P49186 579
type: UnificationXref
id: P49186
db: uniprot

uniprot A0A2I3SXI2 104
type: UnificationXref
id: A0A2I3SXI2
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF200
xref: uniprot G3X7B5 546
organism: Bos taurus

uniprot O93467 624
type: UnificationXref
id: O93467
db: uniprot

PTHR10048:SF48
type: RelationshipXref
id: PTHR10048:SF48
db: PANTHER Family
relationship type: By Homology

Cdc42 protein, putative
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot B7PHY7 513
organism: Ixodes scapularis

uniprot H2QS72 95
type: UnificationXref
id: H2QS72
db: uniprot

STATE_TRANSITION_LEFT__MLK3-RIGHT__MLK3-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 736
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 737
left: MLK3
interaction type: STATE_TRANSITION
right: MLK3

PTHR48016:SF32
type: RelationshipXref
id: PTHR48016:SF32
db: PANTHER Family
relationship type: By Homology

uniprot O61443 323
type: UnificationXref
id: O61443
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pip2-RIGHT__Pip3-_re56
controller: PI3K

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q503B6 156
organism: Danio rerio

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot E2R7W7 494
organism: Canis lupus familiaris

uniprot A0A2I3S8A4 10
type: UnificationXref
id: A0A2I3S8A4
db: uniprot

p38
type: Protein
entity reference: p38
feature: p38 s68 a98 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6S9S9 293
type: UnificationXref
id: F6S9S9
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P17325 379
organism: Rattus norvegicus

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

uniprot B1NA68 418
type: UnificationXref
id: B1NA68
db: uniprot

uniprot P91634 483
type: UnificationXref
id: P91634
db: uniprot

uniprot F7F5X1 141
type: UnificationXref
id: F7F5X1
db: uniprot

Rac family small GTPase 3b
type: ProteinReference
xref: uniprot A9JRY8 339
xref: PTHR24072:SF301
organism: Danio rerio

uniprot Q01986 300
type: UnificationXref
id: Q01986
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot C3ZIB9 515
organism: Branchiostoma floridae

GO GO:0005886 3
type: UnificationXref
id: GO:0005886
db: GO

GSK3 s103 a95 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P61586 628
type: UnificationXref
id: P61586
db: uniprot

uniprot Q7ZVK8 66
type: UnificationXref
id: Q7ZVK8
db: uniprot

uniprot F1MX38 432
type: UnificationXref
id: F1MX38
db: uniprot

uniprot F7E823 50
type: UnificationXref
id: F7E823
db: uniprot

ncbitaxon 44689 119
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot B7PHY7 513
type: UnificationXref
id: B7PHY7
db: uniprot

PTHR23113:SF341
type: RelationshipXref
id: PTHR23113:SF341
db: PANTHER Family
relationship type: By Homology

uniprot P15056 285
type: UnificationXref
id: P15056
db: uniprot

Ras-related protein Ral-B
type: ProteinReference
xref: PTHR24070:SF199
xref: uniprot Q9JIW9 190
organism: Mus musculus

uniprot F7F3S0 464
type: UnificationXref
id: F7F3S0
db: uniprot

uniprot E2RLB2 174
type: UnificationXref
id: E2RLB2
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Proliferation
controller: Elk-1

uniprot Q8CE90 427
type: UnificationXref
id: Q8CE90
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7GLY8 500
organism: Macaca mulatta

uniprot P31938 297
type: UnificationXref
id: P31938
db: uniprot

uniprot H2R5K3 74
type: UnificationXref
id: H2R5K3
db: uniprot

PDK
type: Protein
entity reference: PDK
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7G800 238
type: UnificationXref
id: F7G800
db: uniprot

STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 683
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 682
left: Raf
interaction type: STATE_TRANSITION
right: Raf

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q63932 305
xref: PTHR48013:SF8
organism: Mus musculus

uniprot H9EPM1 113
type: UnificationXref
id: H9EPM1
db: uniprot

uniprot Q9Y243 551
type: UnificationXref
id: Q9Y243
db: uniprot

uniprot A0A1D5QQD3 552
type: UnificationXref
id: A0A1D5QQD3
db: uniprot

STATE_TRANSITION_LEFT__Tiam1-RIGHT__Tiam1-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 672
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 671
left: Tiam1
interaction type: STATE_TRANSITION
right: Tiam1

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot A0A3Q1LJJ3 392
organism: Bos taurus

uniprot E1BE66 451
type: UnificationXref
id: E1BE66
db: uniprot

uniprot Q61411 158
type: UnificationXref
id: Q61411
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6RCU6 543
xref: PTHR24356:SF171
organism: Macaca mulatta

STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 665
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 666
left: PAK
interaction type: STATE_TRANSITION
right: PAK

PDK
type: Protein
entity reference: PDK
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P45983 576
type: UnificationXref
id: P45983
db: uniprot

uniprot A0A3Q1M0G8 227
type: UnificationXref
id: A0A3Q1M0G8
db: uniprot

PTHR47140:SF1
type: RelationshipXref
id: PTHR47140:SF1
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9598 11
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot Q99N57 288
type: UnificationXref
id: Q99N57
db: uniprot

Mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot A0A2I3SB47 416
xref: PTHR48013:SF17
organism: Pan troglodytes

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: uniprot A0A2I3TF56 391
xref: PTHR11849:SF209
organism: Pan troglodytes

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: uniprot F7FH70 395
xref: PTHR11849:SF209
organism: Ornithorhynchus anatinus

uniprot Q0VD16 302
type: UnificationXref
id: Q0VD16
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF14
xref: uniprot A0A3Q1LJI4 105
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42336 476
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P42338 478
xref: PTHR10048:SF33
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 477
organism: Mus musculus

Phosphatidylinositol 3-kinase age-1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q94125 487
organism: Caenorhabditis elegans

Ras-related protein Ral-A
type: ProteinReference
xref: PTHR24070:SF174
xref: uniprot P63322 183
organism: Rattus norvegicus

Ras-related protein Ral-A
type: ProteinReference
xref: PTHR24070:SF174
xref: uniprot P63321 182
organism: Mus musculus

PANTHER Pathway P04393 1
type: UnificationXref
id: P04393
db: PANTHER Pathway

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F1P859 212
organism: Canis lupus familiaris

uniprot A0A2I3RB56 491
type: UnificationXref
id: A0A2I3RB56
db: uniprot

ncbitaxon 7227 103
type: UnificationXref
id: 7227
db: ncbitaxon

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q6PF93 484
organism: Mus musculus

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q95ME4 163
organism: Monodelphis domestica

Glycogen synthase kinase-3 alpha
type: ProteinReference
xref: uniprot P49840 116
xref: PTHR24057:SF14
organism: Homo sapiens

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot P49841 117
organism: Homo sapiens

uniprot P21708 56
type: UnificationXref
id: P21708
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot F6W7C8 460
xref: PTHR10048:SF34
organism: Macaca mulatta

uniprot E9GYE9 516
type: UnificationXref
id: E9GYE9
db: uniprot

PTHR24361:SF414
type: RelationshipXref
id: PTHR24361:SF414
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5NWT4 4
type: UnificationXref
id: A0A1D5NWT4
db: uniprot

PTHR48019:SF40
type: RelationshipXref
id: PTHR48019:SF40
db: PANTHER Family
relationship type: By Homology

uniprot Q8CFN2 531
type: UnificationXref
id: Q8CFN2
db: uniprot

Exocyst complex component 2
type: ProteinReference
xref: uniprot O54921 96
organism: Rattus norvegicus

Rac family small GTPase 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot F7FH99 348
organism: Ornithorhynchus anatinus

uniprot G3X7B5 546
type: UnificationXref
id: G3X7B5
db: uniprot

uniprot P41969 590
type: UnificationXref
id: P41969
db: uniprot

uniprot H2QUG6 177
type: UnificationXref
id: H2QUG6
db: uniprot

uniprot A0A1D5R2N9 192
type: UnificationXref
id: A0A1D5R2N9
db: uniprot

uniprot Q15759 327
type: UnificationXref
id: Q15759
db: uniprot

ncbitaxon 7719 122
type: UnificationXref
id: 7719
db: ncbitaxon

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot Q61831 584
organism: Mus musculus

Complex (Shc/Grb2/ SOS)
type: Complex
component stoichiometry: Grb2 s2 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s3 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Shc s1 sa1 STOICHIOMETRY ID COMPLEX
component: SOS
component: Grb2
component: Shc
feature: COMPLEX BINDING FEATURE s27 a42 655
feature: COMPLEX BINDING FEATURE s27 a42 657
feature: ACTIVE 45
feature: COMPLEX BINDING FEATURE s27 a42 653
cellular location: plasma membrane

uniprot F6WDS0 138
type: UnificationXref
id: F6WDS0
db: uniprot

P04569
type: UnificationXref
id: P04569
db: PANTHER Pathway Component

P04578
type: UnificationXref
id: P04578
db: PANTHER Pathway Component

P04579
type: UnificationXref
id: P04579
db: PANTHER Pathway Component

uniprot H9FYU7 219
type: UnificationXref
id: H9FYU7
db: uniprot

P04574
type: UnificationXref
id: P04574
db: PANTHER Pathway Component

P04575
type: UnificationXref
id: P04575
db: PANTHER Pathway Component

P04572
type: UnificationXref
id: P04572
db: PANTHER Pathway Component

P04573
type: UnificationXref
id: P04573
db: PANTHER Pathway Component

uniprot A0A2I3TNY5 429
type: UnificationXref
id: A0A2I3TNY5
db: uniprot

P04570
type: UnificationXref
id: P04570
db: PANTHER Pathway Component

P04571
type: UnificationXref
id: P04571
db: PANTHER Pathway Component

uniprot O15264 321
type: UnificationXref
id: O15264
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q9XT09 307
xref: PTHR48013:SF5
organism: Pan troglodytes

STATE_TRANSITION_LEFT__Pip2-RIGHT__Pip3-_re56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re56 670
participant stoichiometry: PARTICIPANT STOICHIOMETRY re56 669
left: Pip2
interaction type: STATE_TRANSITION
right: Pip3

RAS like proto-oncogene A
type: ProteinReference
xref: PTHR24070:SF174
xref: uniprot J9NX28 178
organism: Canis lupus familiaris

uniprot F7F5K9 140
type: UnificationXref
id: F7F5K9
db: uniprot

uniprot Q13393 601
type: UnificationXref
id: Q13393
db: uniprot

ncbitaxon 237561 62
type: UnificationXref
id: 237561
db: ncbitaxon

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot A0A3Q1LSJ2 68
organism: Bos taurus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF98
xref: uniprot A0A1D5QL06 8
organism: Macaca mulatta

uniprot Q8NEB9 486
type: UnificationXref
id: Q8NEB9
db: uniprot

uniprot F1PBB6 419
type: UnificationXref
id: F1PBB6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot F7HHY8 404
organism: Macaca mulatta

P04548
type: UnificationXref
id: P04548
db: PANTHER Pathway Component

P04547
type: UnificationXref
id: P04547
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot H3FK05 519
organism: Pristionchus pacificus

PARTICIPANT STOICHIOMETRY r4 678
type: Stoichiometry
physical entity: RalGDS
stoichiometric coefficient: 1.0

P04552
type: UnificationXref
id: P04552
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r4 679
type: Stoichiometry
physical entity: RalGDS
stoichiometric coefficient: 1.0

P04553
type: UnificationXref
id: P04553
db: PANTHER Pathway Component

P04550
type: UnificationXref
id: P04550
db: PANTHER Pathway Component

P04551
type: UnificationXref
id: P04551
db: PANTHER Pathway Component

P04556
type: UnificationXref
id: P04556
db: PANTHER Pathway Component

P04557
type: UnificationXref
id: P04557
db: PANTHER Pathway Component

uniprot P63321 182
type: UnificationXref
id: P63321
db: uniprot

P04555
type: UnificationXref
id: P04555
db: PANTHER Pathway Component

uniprot F1N7C3 211
type: UnificationXref
id: F1N7C3
db: uniprot

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: uniprot F7BFL2 402
xref: PTHR24349:SF64
organism: Macaca mulatta

MAP2K1 protein
type: ProteinReference
xref: uniprot Q0VD16 302
xref: PTHR48013:SF5
organism: Bos taurus

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot J9P5W6 295
xref: PTHR48013:SF5
organism: Canis lupus familiaris

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F6QUW1 214
organism: Monodelphis domestica

ncbitaxon 9913 14
type: UnificationXref
id: 9913
db: ncbitaxon

RAC3 protein
type: ProteinReference
xref: uniprot A5PK69 338
xref: PTHR24072:SF325
organism: Bos taurus

P04559
type: UnificationXref
id: P04559
db: PANTHER Pathway Component

P04558
type: UnificationXref
id: P04558
db: PANTHER Pathway Component

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Vesicle Trafficking
controller: RalBP1

P04561
type: UnificationXref
id: P04561
db: PANTHER Pathway Component

P04563
type: UnificationXref
id: P04563
db: PANTHER Pathway Component

P04564
type: UnificationXref
id: P04564
db: PANTHER Pathway Component

ncbitaxon 45351 509
type: UnificationXref
id: 45351
db: ncbitaxon

P04565
type: UnificationXref
id: P04565
db: PANTHER Pathway Component

RALB protein
type: ProteinReference
xref: PTHR24070:SF199
xref: uniprot A5D977 173
organism: Bos taurus

P04566
type: UnificationXref
id: P04566
db: PANTHER Pathway Component

P04567
type: UnificationXref
id: P04567
db: PANTHER Pathway Component

P04568
type: UnificationXref
id: P04568
db: PANTHER Pathway Component

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9Y243 551
organism: Homo sapiens

uniprot A0A0G2JV91 191
type: UnificationXref
id: A0A0G2JV91
db: uniprot

MAP2K2 isoform 1
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot K7BYT0 296
organism: Pan troglodytes

P04560
type: UnificationXref
id: P04560
db: PANTHER Pathway Component

uniprot H9FU32 275
type: UnificationXref
id: H9FU32
db: uniprot

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot F7CQI0 403
organism: Xenopus tropicalis

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot O93599 435
organism: Danio rerio

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot F7BXX1 384
organism: Xenopus tropicalis

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7FDA0 465
xref: PTHR10048:SF33
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot P31938 297
xref: PTHR48013:SF5
organism: Mus musculus

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P40763 436
organism: Homo sapiens

Exocyst complex component 2
type: ProteinReference
xref: uniprot Q96KP1 100
organism: Homo sapiens

uniprot F1Q118 213
type: UnificationXref
id: F1Q118
db: uniprot

uniprot Q38882 602
type: UnificationXref
id: Q38882
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 47
organism: Bos taurus

Sec5
type: ProteinReference
xref: P04545
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Sec5
comment: ENTITY_REFERENCE_NOTES= Long Name: Sec5 Synonym: Synonym not specified Accession: P04545
member entity reference: Exocyst complex component 2

uniprot F1MYJ4 539
type: UnificationXref
id: F1MYJ4
db: uniprot

uniprot A8XIF5 615
type: UnificationXref
id: A8XIF5
db: uniprot

UNKNOWN_TRANSITION
type: InteractionVocabulary

STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_r62
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 725
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 724
left: SRF
interaction type: STATE_TRANSITION
right: SRF

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot K7CZM1 220
xref: PTHR23113:SF150
organism: Pan troglodytes

uniprot Q7T2E8 643
type: UnificationXref
id: Q7T2E8
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 28

Exocyst complex component 2
type: ProteinReference
xref: uniprot F7HI13 94
organism: Macaca mulatta

Activating transcription factor 2
type: ProteinReference
xref: uniprot A0A2I3RDV4 164
xref: PTHR19304:SF9
organism: Pan troglodytes

uniprot G3MXA5 555
type: UnificationXref
id: G3MXA5
db: uniprot

uniprot Q03385 201
type: UnificationXref
id: Q03385
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot P70236 504
organism: Mus musculus

Activating transcription factor 2
type: ProteinReference
xref: uniprot F1N177 165
xref: PTHR19304:SF9
organism: Bos taurus

uniprot Q9XT09 307
type: UnificationXref
id: Q9XT09
db: uniprot

Rac-like GTP-binding protein 5
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot Q6EP31 366
organism: Oryza sativa

uniprot F6VXG1 459
type: UnificationXref
id: F6VXG1
db: uniprot

STATE_TRANSITION_LEFT__RalGDS-RIGHT__RalGDS-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 679
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 678
left: RalGDS
interaction type: STATE_TRANSITION
right: RalGDS

uniprot P04049 276
type: UnificationXref
id: P04049
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7E823 50
organism: Monodelphis domestica

MAP2K4 protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot A5PJP8 417
organism: Bos taurus

uniprot F7AGV5 497
type: UnificationXref
id: F7AGV5
db: uniprot

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK1_4-RIGHT__MEKK1_4-_r13
controller: Ras

uniprot A0A2I3THL4 267
type: UnificationXref
id: A0A2I3THL4
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60952 525
organism: Canis lupus familiaris

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60953 526
organism: Homo sapiens

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot A0A2I3TK00 268
organism: Pan troglodytes

JNK
type: Protein
entity reference: JNK
feature: JNK s42 a65 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P45985 424
type: UnificationXref
id: P45985
db: uniprot

uniprot Q3ZBW5 637
type: UnificationXref
id: Q3ZBW5
db: uniprot

uniprot Q7PNL6 372
type: UnificationXref
id: Q7PNL6
db: uniprot

uniprot Q22038 633
type: UnificationXref
id: Q22038
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal Reorganization
controller: Rho

Phospholipase
type: ProteinReference
xref: uniprot K7BNT4 595
xref: PTHR18896:SF121
organism: Pan troglodytes

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 21

MEK
type: ProteinReference
xref: P04557
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.MEK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Mitogen activated protein kinase kinase Synonym: MAP kinase kinase,MAPKK,MEK Accession: P04557
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Uncharacterized protein
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase 2
member entity reference: MAP2K2 isoform 1
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: MAP2K1 protein
member entity reference: Mitogen-activated protein kinase kinase 1

GTPase cRac1A
type: ProteinReference
xref: uniprot Q6LC82 369
xref: PTHR24072:SF105
organism: Gallus gallus

STATE_TRANSITION_LEFT__Stat_1_3-RIGHT__Stat_1_3-_r64
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 715
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 714
left: Stat 1/3
interaction type: STATE_TRANSITION
right: Stat 1/3

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F1MAI3 210
organism: Rattus norvegicus

uniprot P53349 76
type: UnificationXref
id: P53349
db: uniprot

MEKK1/4
type: Protein
entity reference: MEKK1/4
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

V-ral simian leukemia viral oncogene homolog Ab (ras-related)
type: ProteinReference
xref: uniprot Q5U3A3 186
organism: Danio rerio

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot F7FP88 385
organism: Monodelphis domestica

uniprot P29353 649
type: UnificationXref
id: P29353
db: uniprot

uniprot E2R6T4 375
type: UnificationXref
id: E2R6T4
db: uniprot

uniprot Q3ZCK2 185
type: UnificationXref
id: Q3ZCK2
db: uniprot

uniprot E1BMX0 132
type: UnificationXref
id: E1BMX0
db: uniprot

By Homology
type: RelationshipTypeVocabulary

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: uniprot P62745 629
xref: PTHR24072:SF0
organism: Homo sapiens

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot A3R0S3 80
xref: PTHR46037:SF4
organism: Gallus gallus

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: uniprot P62747 631
xref: PTHR24072:SF0
organism: Rattus norvegicus

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: uniprot P62746 630
xref: PTHR24072:SF0
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EH19 51
xref: PTHR24055:SF203
organism: Xenopus tropicalis

uniprot Q28CF3 184
type: UnificationXref
id: Q28CF3
db: uniprot

Shc s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 743
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Growth factor receptor s4 sa4 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.810151213339066

uniprot F1N8W8 232
type: UnificationXref
id: F1N8W8
db: uniprot

PARTICIPANT STOICHIOMETRY r1 695
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 693
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 694
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot Q3UMW7 412
type: UnificationXref
id: Q3UMW7
db: uniprot

Ribosomal protein S6 kinase alpha-3
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot P51812 39
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r21 742
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 692
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot H2QNG6 470
type: UnificationXref
id: H2QNG6
db: uniprot

Pip3
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A3S5ZPX3 291
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

uniprot A0A2I3SB47 416
type: UnificationXref
id: A0A2I3SB47
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P70618 326
xref: PTHR24055:SF110
organism: Rattus norvegicus

Cdc42 homolog
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot P40793 523
organism: Drosophila melanogaster

uniprot E1BS97 228
type: UnificationXref
id: E1BS97
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot Q9JHG7 488
xref: PTHR10048:SF34
organism: Mus musculus

uniprot A5PK69 338
type: UnificationXref
id: A5PK69
db: uniprot

uniprot Q02750 301
type: UnificationXref
id: Q02750
db: uniprot

uniprot Q5U3A3 186
type: UnificationXref
id: Q5U3A3
db: uniprot

uniprot P27361 57
type: UnificationXref
id: P27361
db: uniprot

uniprot H2QML4 623
type: UnificationXref
id: H2QML4
db: uniprot

uniprot F7B5L8 571
type: UnificationXref
id: F7B5L8
db: uniprot

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot O75914 241
organism: Homo sapiens

Ral guanine nucleotide dissociation stimulator,-like 1
type: ProteinReference
xref: uniprot A0A0G2JV91 191
organism: Rattus norvegicus

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47196 549
xref: PTHR24356:SF171
organism: Rattus norvegicus

Neuroblastoma RAS viral (v-ras) oncogene homolog
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot F6WDS0 138
organism: Xenopus tropicalis

uniprot A0A3Q1MNG1 492
type: UnificationXref
id: A0A3Q1MNG1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r32
controller: Ras

uniprot O54921 96
type: UnificationXref
id: O54921
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Sec5-RIGHT__Sec5-_r28
controller: Ral

uniprot E1B8P9 47
type: UnificationXref
id: E1B8P9
db: uniprot

uniprot F1PH12 383
type: UnificationXref
id: F1PH12
db: uniprot

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot Q7YQL4 250
organism: Pan troglodytes

ERK
type: ProteinReference
xref: P04542
standard name: Extracellular signal-regulated kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: Extracellular signal-regulated kinase Synonym: ERK,MAP kinase,MAPK,Mitogen activated protein kinase Accession: P04542
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.ERK
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Uncharacterized protein
member entity reference: Extracellular signal-regulated kinase 1

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot A0A3Q1LJZ7 308
organism: Bos taurus

Ral guanine nucleotide dissociation stimulator-like 1
type: ProteinReference
xref: uniprot Q60695 205
organism: Mus musculus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF98
xref: uniprot A0A2I3S8A4 10
organism: Pan troglodytes

p14/19 ARF
type: Protein
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 161

LOC100170599 protein
type: ProteinReference
xref: uniprot B3DM35 393
xref: PTHR11849:SF209
organism: Xenopus tropicalis

uniprot Q4KSH7 426
type: UnificationXref
id: Q4KSH7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F3S0 464
xref: PTHR10048:SF33
organism: Macaca mulatta

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F6Z5N3 139
organism: Monodelphis domestica

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot Q62925 78
xref: PTHR24361:SF414
organism: Rattus norvegicus

uniprot P60952 525
type: UnificationXref
id: P60952
db: uniprot

uniprot F7BAS2 236
type: UnificationXref
id: F7BAS2
db: uniprot

uniprot P63001 358
type: UnificationXref
id: P63001
db: uniprot

PARTICIPANT STOICHIOMETRY r36 704
type: Stoichiometry
physical entity: MKK3/6
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot A0A1D5QKD3 290
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r36 705
type: Stoichiometry
physical entity: MKK3/6
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RSB0 312
xref: PTHR24055:SF146
organism: Canis lupus familiaris

PTHR24070:SF174
type: RelationshipXref
id: PTHR24070:SF174
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot Q13153 245
xref: PTHR48015:SF20
organism: Homo sapiens

uniprot F6RCU6 543
type: UnificationXref
id: F6RCU6
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot P48736 479
xref: PTHR10048:SF34
organism: Homo sapiens

Ras
type: Protein
entity reference: Ras
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H2PXY8 469
xref: PTHR10048:SF35
organism: Pan troglodytes

Exocyst complex component 2
type: ProteinReference
xref: uniprot Q22706 97
organism: Caenorhabditis elegans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AP1-RIGHT__AP1-_r63
controller: ERK

uniprot Q08E52 244
type: UnificationXref
id: Q08E52
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05412 377
organism: Homo sapiens

uniprot W4Y0P1 125
type: UnificationXref
id: W4Y0P1
db: uniprot

uniprot E1C3P6 229
type: UnificationXref
id: E1C3P6
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot H9FYU7 219
organism: Macaca mulatta

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot Q3T0F9 84
xref: PTHR46037:SF4
organism: Bos taurus

uniprot Q66JE6 306
type: UnificationXref
id: Q66JE6
db: uniprot

STATE_TRANSITION_LEFT__p38-RIGHT__p38-_r37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 702
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 703
left: p38
interaction type: STATE_TRANSITION
right: p38

STATE_TRANSITION_LEFT__RalBP1-RIGHT__RalBP1-_r27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 731
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 730
left: RalBP1
interaction type: STATE_TRANSITION
right: RalBP1

STATE_TRANSITION_LEFT__ATF2-RIGHT__ATF2-_r66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 708
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 709
left: ATF2
interaction type: STATE_TRANSITION
right: ATF2

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r43
controller: ERK

uniprot A0A0G2K3R1 67
type: UnificationXref
id: A0A0G2K3R1
db: uniprot

uniprot Q6DV79 441
type: UnificationXref
id: Q6DV79
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1PMN2 566
xref: PTHR24055:SF162
organism: Canis lupus familiaris

HETERODIMER_ASSOCIATION_LEFT__SOS-_Shc-_Grb2-RIGHT__Complex__Shc_Grb2__SOS_-_r11
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 698
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 697
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 699
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 696
left: Grb2
left: Shc
left: SOS
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Shc/Grb2/ SOS)

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK3_6-RIGHT__MKK3_6-_r36
controller: TAK

STATE_TRANSITION_LEFT__GTP-_Ral-RIGHT__GDP-_Ral-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 687
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 684
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 686
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 685
left: Ral
left: GTP
interaction type: STATE_TRANSITION
right: GDP
right: Ral

PTHR10337:SF2
type: RelationshipXref
id: PTHR10337:SF2
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5R9X3 428
type: UnificationXref
id: A0A1D5R9X3
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q90694 532
xref: PTHR24072:SF136
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot F7ES59 621
organism: Monodelphis domestica

Raf
type: Protein
entity reference: Raf
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NCY7 400
organism: Gallus gallus

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q9Z2A0 261
xref: PTHR24356:SF163
organism: Mus musculus

PTHR24351:SF98
type: RelationshipXref
id: PTHR24351:SF98
db: PANTHER Family
relationship type: By Homology

uniprot A0A452DI16 270
type: UnificationXref
id: A0A452DI16
db: uniprot

uniprot P19419 589
type: UnificationXref
id: P19419
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK3_6-RIGHT__MKK3_6-_r36
controller: MEKK1/4

uniprot A0A1D5QAU9 415
type: UnificationXref
id: A0A1D5QAU9
db: uniprot

uniprot P79996 582
type: UnificationXref
id: P79996
db: uniprot

Rac
type: Protein
entity reference: Rac
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P62998 355
type: UnificationXref
id: P62998
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7FHD1 53
xref: PTHR24055:SF203
organism: Monodelphis domestica

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O55173 255
organism: Rattus norvegicus

MAPKAP s60 a82 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.74176493209759

uniprot Q17031 527
type: UnificationXref
id: Q17031
db: uniprot

MAPKAP s60 a82 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5205801522987876
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY r28 728
type: Stoichiometry
physical entity: Sec5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r28 729
type: Stoichiometry
physical entity: Sec5
stoichiometric coefficient: 1.0

uniprot A0A1D5PXC6 560
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RKA7 311
xref: PTHR24055:SF107
organism: Canis lupus familiaris

PTHR24072:SF192
type: RelationshipXref
id: PTHR24072:SF192
db: PANTHER Family
relationship type: By Homology

uniprot Q9VQQ9 102
type: UnificationXref
id: Q9VQQ9
db: uniprot

uniprot P70498 598
type: UnificationXref
id: P70498
db: uniprot

STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 681
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 680
left: Rac
interaction type: STATE_TRANSITION
right: Rac

p90RSK
type: Protein
entity reference: p90RSK
feature: p90RSK s56 a81 rs1
feature: p90RSK s56 a81 rs2
feature: ACTIVE 45
feature: p90RSK s56 a81 rs3
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot A0A2I3SXI2 104
xref: PTHR24057:SF8
organism: Pan troglodytes

MAPKAP s60 a82 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8273977914520914
comment: MODIFICATION_RESIDUE_NAME=

PI-3 kinase
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot P91634 483
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XSJ9 346
xref: PTHR24072:SF136
organism: Macaca mulatta

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 289
xref: PTHR44329:SF22
xref: uniprot Q99N57 288
organism: Mus musculus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 40

MEK
type: Protein
entity reference: MEK
feature: MEK s50 a71 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q60610 558
type: UnificationXref
id: Q60610
db: uniprot

uniprot P97813 599
type: UnificationXref
id: P97813
db: uniprot

uniprot A0A1D5RHD1 490
type: UnificationXref
id: A0A1D5RHD1
db: uniprot

uniprot Q61831 584
type: UnificationXref
id: Q61831
db: uniprot

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

uniprot F6ZTS0 316
type: UnificationXref
id: F6ZTS0
db: uniprot

uniprot Q9JIW9 190
type: UnificationXref
id: Q9JIW9
db: uniprot

RalGDS
type: ProteinReference
xref: P04551
standard name: Ral guanine nucleotide dissociation stimulator
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Ral guanine nucleotide dissociation stimulator Synonym: RalGDS Accession: P04551
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.RalGDS
member entity reference: Ral guanine nucleotide dissociation stimulator,-like 1
member entity reference: Ral guanine nucleotide dissociation stimulator-like 2
member entity reference: RALGDS isoform 4
member entity reference: Ral guanine nucleotide dissociation stimulator-like 1
member entity reference: Ral guanine nucleotide dissociation stimulator
member entity reference: RGL2 isoform 1
member entity reference: RGL1 isoform 1
member entity reference: Uncharacterized protein
member entity reference: RAB2, member RAS oncogene family-like

uniprot E2RB53 108
type: UnificationXref
id: E2RB53
db: uniprot

uniprot H2QS62 574
type: UnificationXref
id: H2QS62
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6Y4G8 569
organism: Canis lupus familiaris

PTHR24351:SF43
type: RelationshipXref
id: PTHR24351:SF43
db: PANTHER Family
relationship type: By Homology

PTHR24072:SF153
type: RelationshipXref
id: PTHR24072:SF153
db: PANTHER Family
relationship type: By Homology

uniprot O93599 435
type: UnificationXref
id: O93599
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q1HG70 303
xref: PTHR48013:SF8
organism: Canis lupus familiaris

Proliferation
type: Pathway

PDK
type: ProteinReference
xref: P04555
standard name: 3-phosphoinositide-dependent protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Phosphoinositide dependent kinase Synonym: PDK Accession: P04555
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.PDK
member entity reference: 3-phosphoinositide-dependent protein kinase 1
member entity reference: Serine/threonine-protein kinase ppk21
member entity reference: 3-phosphoinositide dependent protein kinase 1
member entity reference: Uncharacterized protein

uniprot F1PCQ4 166
type: UnificationXref
id: F1PCQ4
db: uniprot

MKK3 6 s66 a96 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A1D5QXL5 390
type: UnificationXref
id: A0A1D5QXL5
db: uniprot

RalGDS
type: Protein
entity reference: RalGDS
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot P08644 148
organism: Rattus norvegicus

GSK3
type: Protein
entity reference: GSK3
feature: GSK3 s103 a95 rs1
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

GTPase HRas
type: ProteinReference
xref: uniprot P08642 147
xref: PTHR24070:SF423
organism: Gallus gallus

uniprot P26675 221
type: UnificationXref
id: P26675
db: uniprot

uniprot P63322 183
type: UnificationXref
id: P63322
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot A0A1D5NWT4 4
organism: Gallus gallus

uniprot Q60695 205
type: UnificationXref
id: Q60695
db: uniprot

p90RSK
type: ProteinReference
xref: P04541
standard name: Ribosomal protein S6 kinase, 90kD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: p90 ribosomal S6 kinase Synonym: MAPK-activated protein kinase-1,MAPKAP-KI,p90RSK Accession: P04541
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.p90RSK
member entity reference: Ribosomal protein S6 kinase
member entity reference: Ribosomal protein S6 kinase alpha-3
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: Ribosomal protein S6 kinase alpha-1
member entity reference: Ribosomal protein S6 kinase alpha-6
member entity reference: Ribosomal protein S6 kinase alpha-2
member entity reference: Ribosomal protein S6 kinase 2 alpha

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot Q66H84 413
organism: Rattus norvegicus

AP1 s90 a114 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR24351:SF58
type: RelationshipXref
id: PTHR24351:SF58
db: PANTHER Family
relationship type: By Homology

uniprot P47811 324
type: UnificationXref
id: P47811
db: uniprot

PTHR24072:SF168
type: RelationshipXref
id: PTHR24072:SF168
db: PANTHER Family
relationship type: By Homology

uniprot Q95NE7 331
type: UnificationXref
id: Q95NE7
db: uniprot

Elk-1
type: Protein
entity reference: Elk-1
feature: ACTIVE 45
feature: Elk 1 s89 a118 rs1
feature: Elk 1 s89 a118 rs2
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q07889 223
type: UnificationXref
id: Q07889
db: uniprot

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

uniprot F7GEK1 545
type: UnificationXref
id: F7GEK1
db: uniprot

RAB2, member RAS oncogene family-like
type: ProteinReference
xref: uniprot Q6MGC5 207
xref: PTHR23113:SF213
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6V332 314
xref: PTHR24055:SF110
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF14
xref: uniprot F1PAE3 109
organism: Canis lupus familiaris

uniprot E2R9L4 70
type: UnificationXref
id: E2R9L4
db: uniprot

ATF2 s75 a106 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.865087513468231
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Ras
type: ProteinReference
xref: P04547
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Ras
comment: ENTITY_REFERENCE_NOTES= Long Name: Ras Synonym: Synonym not specified Accession: P04547
member entity reference: NRAS protein
member entity reference: Uncharacterized protein
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: GTPase KRas
member entity reference: Ras protein let-60
member entity reference: Protein CBR-LET-60
member entity reference: KRAS isoform 4
member entity reference: GTPase HRas
member entity reference: AGAP002219-PA
member entity reference: GTPase NRas
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: Ras-like protein
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: Kirsten rat sarcoma viral oncogene homolog
member entity reference: Neuroblastoma RAS viral (v-ras) oncogene homolog
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: Zgc:55558
member entity reference: GTPase HRas isoform 1
member entity reference: NRAS isoform 1

uniprot F1Q3M8 455
type: UnificationXref
id: F1Q3M8
db: uniprot

uniprot B8JIQ1 107
type: UnificationXref
id: B8JIQ1
db: uniprot

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r43 701
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot A0A1D5QXL5 390
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r43 700
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

Growth factor receptor s6 a6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.810151213339066

STATE_TRANSITION_LEFT__Sec5-RIGHT__Sec5-_r28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 728
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 729
left: Sec5
interaction type: STATE_TRANSITION
right: Sec5

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Glycogen synthase kinase-3 alpha
type: ProteinReference
xref: uniprot Q2NL51 120
xref: PTHR24057:SF14
organism: Mus musculus

uniprot Q9Z1B7 337
type: UnificationXref
id: Q9Z1B7
db: uniprot

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: uniprot F1QNG4 136
xref: PTHR24070:SF423
organism: Danio rerio

uniprot F7FR08 622
type: UnificationXref
id: F7FR08
db: uniprot

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q9QUI0 646
organism: Mus musculus

uniprot Q61036 247
type: UnificationXref
id: Q61036
db: uniprot

uniprot F7FFF4 592
type: UnificationXref
id: F7FFF4
db: uniprot

uniprot P31749 547
type: UnificationXref
id: P31749
db: uniprot

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 577

PLD
type: ProteinReference
xref: P04574
standard name: Phospholipase D
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Phospholipase D Synonym: PLD Accession: P04574
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.PLD
member entity reference: Phospholipase D gamma 1
member entity reference: Phospholipase
member entity reference: Phospholipase D2
member entity reference: Phospholipase D1
member entity reference: Phospholipase D gamma 3
member entity reference: Phospholipase D
member entity reference: Phospholipase D alpha 1

uniprot P70618 326
type: UnificationXref
id: P70618
db: uniprot

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot A0A3S5ZPX3 291
xref: PTHR48013:SF8
organism: Bos taurus

uniprot A0A3Q1LSY0 226
type: UnificationXref
id: A0A3Q1LSY0
db: uniprot

uniprot A0A3Q1LJI4 105
type: UnificationXref
id: A0A3Q1LJI4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MYM3 454
xref: PTHR10048:SF33
organism: Bos taurus

Phosphatidylinositol 3-kinase 3
type: ProteinReference
xref: uniprot P54675 482
xref: PTHR10048:SF48
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 2
type: ProteinReference
xref: uniprot P54674 481
xref: PTHR10048:SF109
organism: Dictyostelium discoideum

uniprot Q94125 487
type: UnificationXref
id: Q94125
db: uniprot

Phosphatidylinositol 3-kinase 1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot P54673 480
organism: Dictyostelium discoideum

Cytoskeletal Reorganization
type: Pathway

uniprot Q1RMJ6 632
type: UnificationXref
id: Q1RMJ6
db: uniprot

ACTIVE 45
type: EntityFeature
comment: Active state

uniprot P42224 437
type: UnificationXref
id: P42224
db: uniprot

Phospholipase D2
type: ProteinReference
xref: uniprot P97813 599
xref: PTHR18896:SF121
organism: Mus musculus

uniprot Q9YH60 124
type: UnificationXref
id: Q9YH60
db: uniprot

uniprot Q38903 361
type: UnificationXref
id: Q38903
db: uniprot

Phospholipase D2
type: ProteinReference
xref: PTHR18896:SF121
xref: uniprot Q0V8L6 600
organism: Bos taurus

MEKK1/4
type: ProteinReference
xref: P04543
standard name: Mitogen activated protein kinase kinase kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: Mitogen activated protein kinase kinase kinase Synonym: MAPKKK,MEK kinase,MEKK1,MEKK4 Accession: P04543
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.MEKK1/4
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase kinase 1
member entity reference: Mitogen-activated protein kinase kinase kinase 4

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A3Q1LNQ6 13
xref: PTHR24351:SF213
organism: Bos taurus

uniprot P70236 504
type: UnificationXref
id: P70236
db: uniprot

uniprot Q6LC82 369
type: UnificationXref
id: Q6LC82
db: uniprot

uniprot A0A1D5QE27 444
type: UnificationXref
id: A0A1D5QE27
db: uniprot

uniprot Q05144 359
type: UnificationXref
id: Q05144
db: uniprot

STATE_TRANSITION_LEFT__GSK3-RIGHT__GSK3-_r35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 707
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 706
left: GSK3
interaction type: STATE_TRANSITION
right: GSK3

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: uniprot Q3ZBW5 637
xref: PTHR24072:SF0
organism: Bos taurus

uniprot F7CYE3 572
type: UnificationXref
id: F7CYE3
db: uniprot

PARTICIPANT STOICHIOMETRY r62 725
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

uniprot O88643 242
type: UnificationXref
id: O88643
db: uniprot

PARTICIPANT STOICHIOMETRY r62 724
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

uniprot A3R0S3 80
type: UnificationXref
id: A3R0S3
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q3T0N5 329
xref: PTHR24055:SF107
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RalGDS-RIGHT__RalGDS-_r4
controller: Ras

Ral guanine nucleotide dissociation stimulator-like 2
type: ProteinReference
xref: PTHR23113:SF213
xref: uniprot Q0VCY4 203
organism: Bos taurus

uniprot E2RL20 272
type: UnificationXref
id: E2RL20
db: uniprot

uniprot P05412 377
type: UnificationXref
id: P05412
db: uniprot

PARTICIPANT STOICHIOMETRY r64 714
type: Stoichiometry
physical entity: Stat 1/3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 715
type: Stoichiometry
physical entity: Stat 1/3
stoichiometric coefficient: 1.0

uniprot P01111 143
type: UnificationXref
id: P01111
db: uniprot

uniprot A0A3Q1NAC7 193
type: UnificationXref
id: A0A3Q1NAC7
db: uniprot

Apoptosis
type: Pathway

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF98
xref: uniprot A0A3Q1LXK8 15
organism: Bos taurus

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q28EW2 155
organism: Xenopus tropicalis

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__GSK3-RIGHT__GSK3-_r35
control type: INHIBITION
controller: AKT

Protein C-ets-1
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot P41156 398
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7BAS2 236
xref: PTHR48015:SF30
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot E9I1I7 133
organism: Daphnia pulex

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0R4IKK9 559
xref: PTHR24055:SF162
organism: Danio rerio

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1MYJ4 539
organism: Bos taurus

uniprot Q9TU25 374
type: UnificationXref
id: Q9TU25
db: uniprot

uniprot Q13233 77
type: UnificationXref
id: Q13233
db: uniprot

Exocyst complex component 2
type: ProteinReference
xref: uniprot Q9VQQ9 102
organism: Drosophila melanogaster

PTHR24072:SF100
type: RelationshipXref
id: PTHR24072:SF100
db: PANTHER Family
relationship type: By Homology

Candida albicans
type: BioSource
xref: ncbitaxon 237561 62

PARTICIPANT STOICHIOMETRY r18 665
type: Stoichiometry
physical entity: PAK
stoichiometric coefficient: 1.0

p53 pathway
type: Pathway

uniprot C4M5T0 342
type: UnificationXref
id: C4M5T0
db: uniprot

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r18 666
type: Stoichiometry
physical entity: PAK
stoichiometric coefficient: 1.0

uniprot P45984 578
type: UnificationXref
id: P45984
db: uniprot

Ras homolog family member C
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot A0A0G2K6E0 613
organism: Rattus norvegicus

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot P98083 650
organism: Mus musculus

ncbitaxon 7739 341
type: UnificationXref
id: 7739
db: ncbitaxon

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot E2RJX4 537
organism: Canis lupus familiaris

uniprot F7HLC7 468
type: UnificationXref
id: F7HLC7
db: uniprot

uniprot P53778 325
type: UnificationXref
id: P53778
db: uniprot

p38 s105 a99 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot H2QNG6 470
xref: PTHR10048:SF33
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1Q4F8 540
organism: Canis lupus familiaris

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7H7W3 33
type: UnificationXref
id: F7H7W3
db: uniprot

uniprot F6Z5N3 139
type: UnificationXref
id: F6Z5N3
db: uniprot

PTHR23113:SF213
type: RelationshipXref
id: PTHR23113:SF213
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot A0A0G2K3R1 67
xref: PTHR48016:SF32
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F7GN93 573
organism: Macaca mulatta

uniprot P14056 284
type: UnificationXref
id: P14056
db: uniprot

uniprot Q9WTU6 587
type: UnificationXref
id: Q9WTU6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATF2-RIGHT__ATF2-_r66
controller: p38

p38 s68 a98 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: uniprot Q13177 246
xref: PTHR48015:SF22
organism: Homo sapiens

PTHR24070:SF199
type: RelationshipXref
id: PTHR24070:SF199
db: PANTHER Family
relationship type: By Homology

uniprot K7D2P2 387
type: UnificationXref
id: K7D2P2
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot Q8CE90 427
xref: PTHR48013:SF17
organism: Mus musculus

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 277
xref: uniprot P04049 276
xref: PTHR44329:SF22
organism: Homo sapiens

Exocyst complex component 2
type: ProteinReference
xref: uniprot F7CDZ8 93
organism: Monodelphis domestica

uniprot A8X0X5 130
type: UnificationXref
id: A8X0X5
db: uniprot

uniprot F6Y1Z2 394
type: UnificationXref
id: F6Y1Z2
db: uniprot

Grb2
type: ProteinReference
xref: P04544
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Grb2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Growth factor receptor-bound protein-2 Synonym: Synonym not specified Accession: P04544
member entity reference: Growth factor receptor-bound protein 2
member entity reference: Growth factor receptor-bound protein 2a
member entity reference: GRB2 isoform 3

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YJC1 340
xref: PTHR24072:SF281
organism: Branchiostoma floridae

AKT
type: ProteinReference
xref: P04570
standard name: protein kinase B
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.AKT
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: AKT Synonym: PKB,Protein Kinase B Accession: P04570
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase

uniprot H2QGF9 112
type: UnificationXref
id: H2QGF9
db: uniprot

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

AKT s64 a92 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

T-cell lymphoma invasion and metastasis 1
type: ProteinReference
xref: PTHR46001:SF1
xref: uniprot H2QKY3 556
organism: Pan troglodytes

uniprot F6YCI3 216
type: UnificationXref
id: F6YCI3
db: uniprot

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: uniprot Q64303 249
xref: PTHR48015:SF22
organism: Rattus norvegicus

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P79996 582
organism: Gallus gallus

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63001 358
xref: PTHR24072:SF105
organism: Mus musculus

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63000 357
xref: PTHR24072:SF105
organism: Homo sapiens

MKK3/6
type: Protein
entity reference: MKK3/6
feature: MKK3 6 s67 a97 rs1
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Elk-1
type: Protein
entity reference: Elk-1
feature: Elk 1 s87 a117 rs2
feature: Elk 1 s87 a117 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9544 9
type: UnificationXref
id: 9544
db: ncbitaxon

ncbitaxon 54126 520
type: UnificationXref
id: 54126
db: ncbitaxon

uniprot Q9DGE0 507
type: UnificationXref
id: Q9DGE0
db: uniprot

uniprot P49841 117
type: UnificationXref
id: P49841
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NAC7 193
organism: Bos taurus

uniprot Q9WTY9 335
type: UnificationXref
id: Q9WTY9
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: p53 pathway
controller: p14/19 ARF

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot F7C798 317
organism: Macaca mulatta

Vesicle Trafficking
type: Pathway

uniprot F1PXS7 49
type: UnificationXref
id: F1PXS7
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot A0A2I3T9Y4 535
organism: Pan troglodytes

uniprot Q9WUI1 336
type: UnificationXref
id: Q9WUI1
db: uniprot

uniprot Q03386 202
type: UnificationXref
id: Q03386
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Proliferation
controller: AP1

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

Grb2
type: Protein
entity reference: Grb2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot H9FVU5 471
type: UnificationXref
id: H9FVU5
db: uniprot

Cell division cycle 42
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q28BZ0 528
organism: Xenopus tropicalis

uniprot Q7QK91 160
type: UnificationXref
id: Q7QK91
db: uniprot

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: uniprot P08134 626
xref: PTHR24072:SF100
organism: Homo sapiens

Transcription factor AP-1
type: ProteinReference
xref: uniprot O77627 376
xref: PTHR11462:SF8
organism: Bos taurus

uniprot Q9Y6R4 79
type: UnificationXref
id: Q9Y6R4
db: uniprot

uniprot Q2NL51 120
type: UnificationXref
id: Q2NL51
db: uniprot

uniprot P31750 548
type: UnificationXref
id: P31750
db: uniprot

PAK
type: ProteinReference
xref: P04553
standard name: P21 activated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.PAK
comment: ENTITY_REFERENCE_NOTES= Long Name: P21 activated kinase Synonym: PAK Accession: P04553
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: Serine/threonine-protein kinase PAK 1
member entity reference: Serine/threonine-protein kinase PAK 3
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase PAK 2

uniprot F1N177 165
type: UnificationXref
id: F1N177
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6V2V1 27
xref: PTHR24351:SF58
organism: Ornithorhynchus anatinus

Glycogen synthase kinase 3 alpha
type: ProteinReference
xref: PTHR24057:SF14
xref: uniprot H2QGF9 112
organism: Pan troglodytes

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot O14733 423
xref: PTHR48013:SF17
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot E1B847 69
xref: PTHR24361:SF414
organism: Bos taurus

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 743
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 742
left: MEK
interaction type: STATE_TRANSITION
right: MEK

Stat 1/3
type: Protein
entity reference: Stat 1/3
feature: Stat 1 3 s78 a109 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot A4GTP4 588
xref: PTHR11849:SF178
organism: Rattus norvegicus

uniprot F7EI48 52
type: UnificationXref
id: F7EI48
db: uniprot

uniprot Q9Z2A0 261
type: UnificationXref
id: Q9Z2A0
db: uniprot

Growth factor receptor s4 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Growth factor receptor
stoichiometric coefficient: 2.0

Cdc42
type: Protein
entity reference: Cdc42
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9NZL6 208
type: UnificationXref
id: Q9NZL6
db: uniprot

uniprot A0A2I3T6U4 127
type: UnificationXref
id: A0A2I3T6U4
db: uniprot

Rac-like GTP-binding protein 6
type: ProteinReference
xref: uniprot Q6ZHA3 371
xref: PTHR24072:SF287
organism: Oryza sativa

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 11

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: uniprot Q8CIN4 251
xref: PTHR48015:SF22
organism: Mus musculus

SRF
type: ProteinReference
xref: P04561
standard name: Serum response factor
comment: ENTITY_REFERENCE_NOTES= Long Name: Serum response factor Synonym: SRF Accession: P04561
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.SRF
member entity reference: Serum response factor
member entity reference: SRF isoform 1
member entity reference: Uncharacterized protein
member entity reference: Serum response factor a

MAPKAPK2 isoform 1
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot H2Q104 405
organism: Pan troglodytes

Rac
type: ProteinReference
xref: P04559
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Rac
comment: ENTITY_REFERENCE_NOTES= Long Name: Rac Synonym: Synonym not specified Accession: P04559
member entity reference: Uncharacterized protein
member entity reference: Rac family small GTPase 3b
member entity reference: Rac-like GTP-binding protein 6
member entity reference: Rac family small GTPase 2
member entity reference: Rac family small GTPase 1a
member entity reference: Rac-like GTP-binding protein 5
member entity reference: Rac-like GTP-binding protein ARAC2
member entity reference: AGAP005445-PA
member entity reference: RAC3 protein
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Rac family small GTPase 1b
member entity reference: Ras-related C3 botulinum toxin substrate 3
member entity reference: GTPase cRac1A
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Rac family small GTPase 3
member entity reference: Rac family small GTPase 1
member entity reference: Rac family small GTPase 3a
member entity reference: Rho family GTPase
member entity reference: Ras-related protein Rac2
member entity reference: Rho-related protein racB
member entity reference: Rac-like GTP-binding protein ARAC4

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q15759 327
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
evidence: Evidence 263
evidence: Evidence 265
evidence: Evidence 266
evidence: Evidence 264
xref: uniprot A0A1D5R9U8 262
xref: PTHR44329:SF22
organism: Macaca mulatta

uniprot P01112 144
type: UnificationXref
id: P01112
db: uniprot

uniprot D3ZFJ0 449
type: UnificationXref
id: D3ZFJ0
db: uniprot

uniprot H2R8U9 218
type: UnificationXref
id: H2R8U9
db: uniprot

uniprot F6XP81 544
type: UnificationXref
id: F6XP81
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: MEK s52 a74 rs1
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r22
controller: MEK

uniprot A0A0R4IKK9 559
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

uniprot F6Y841 461
type: UnificationXref
id: F6Y841
db: uniprot

uniprot P11831 388
type: UnificationXref
id: P11831
db: uniprot

uniprot O09110 501
type: UnificationXref
id: O09110
db: uniprot

STATE_TRANSITION_LEFT__AP1-RIGHT__AP1-_r63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 719
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 718
left: AP1
interaction type: STATE_TRANSITION
right: AP1

Transforming protein RhoA
type: ProteinReference
xref: uniprot P61585 627
xref: PTHR24072:SF153
organism: Bos taurus

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot P61586 628
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Tiam1-RIGHT__Tiam1-_r5
controller: Ras

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 283
xref: PTHR44329:SF22
xref: uniprot P11345 282
organism: Rattus norvegicus

Ets
type: ProteinReference
xref: P04563
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Ets
comment: ENTITY_REFERENCE_NOTES= Long Name: Ets Synonym: Synonym not specified Accession: P04563
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Protein C-ets-1
member entity reference: Uncharacterized protein
member entity reference: ETS proto-oncogene 1, transcription factor
member entity reference: LOC100170599 protein

uniprot F6W3Y0 234
type: UnificationXref
id: F6W3Y0
db: uniprot

uniprot F7G8G5 434
type: UnificationXref
id: F7G8G5
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot O15264 321
xref: PTHR24055:SF107
organism: Homo sapiens

ncbitaxon 9615 21
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot P62745 629
type: UnificationXref
id: P62745
db: uniprot

plasma membrane
type: CellularLocationVocabulary
xref: GO GO:0005886 3

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot A0A3Q1M614 399
organism: Bos taurus

uniprot Q29RC5 360
type: UnificationXref
id: Q29RC5
db: uniprot

uniprot Q925D6 506
type: UnificationXref
id: Q925D6
db: uniprot

Rac family small GTPase 2
type: ProteinReference
xref: uniprot F6YFT0 347
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-_GTP-RIGHT__GDP-_Ras-_r1
controller: Complex (Shc/Grb2/ SOS)

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q04970 152
organism: Rattus norvegicus

PTHR24356:SF163
type: RelationshipXref
id: PTHR24356:SF163
db: PANTHER Family
relationship type: By Homology

uniprot F6RBZ7 517
type: UnificationXref
id: F6RBZ7
db: uniprot

Ras homolog family member C
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot A0A2I3S4I6 614
organism: Pan troglodytes

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot O88643 242
xref: PTHR48015:SF20
organism: Mus musculus

uniprot F6T2E7 233
type: UnificationXref
id: F6T2E7
db: uniprot

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot Q1LYG2 287
organism: Danio rerio

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot Q07890 224
organism: Homo sapiens

uniprot F6R680 92
type: UnificationXref
id: F6R680
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6W3Y0 234
xref: PTHR48015:SF30
organism: Xenopus tropicalis

uniprot A0A0G2K344 442
type: UnificationXref
id: A0A0G2K344
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E9FRC3 344
xref: PTHR24072:SF281
organism: Daphnia pulex

Phospholipase D gamma 1
type: ProteinReference
xref: uniprot Q9T053 607
organism: Arabidopsis thaliana

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F7B5L8 571
organism: Ornithorhynchus anatinus

Phospholipase D gamma 3
type: ProteinReference
xref: uniprot Q9T052 606
organism: Arabidopsis thaliana

uniprot Q6DHM9 640
type: UnificationXref
id: Q6DHM9
db: uniprot

Rala protein
type: ProteinReference
xref: PTHR24070:SF174
xref: uniprot Q7T383 189
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QLH3 610
xref: PTHR47140:SF1
organism: Macaca mulatta

uniprot Q63538 330
type: UnificationXref
id: Q63538
db: uniprot

STATE_TRANSITION_LEFT__PLD-RIGHT__PLD-_r29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 726
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 727
left: PLD
interaction type: STATE_TRANSITION
right: PLD

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 9

MEK s50 a71 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

AKT s104 a93 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q6DC92 187
type: UnificationXref
id: Q6DC92
db: uniprot

Exocyst complex component 2
type: ProteinReference
xref: uniprot F1P2A7 91
organism: Gallus gallus

Protein son of sevenless
type: ProteinReference
xref: uniprot P26675 221
xref: PTHR23113:SF341
organism: Drosophila melanogaster

uniprot A0A3Q1M614 399
type: UnificationXref
id: A0A3Q1M614
db: uniprot

ATF2 s75 a106 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=2.491344174153594
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q9TU25 374
xref: PTHR24072:SF169
organism: Bos taurus

uniprot F6WV79 568
type: UnificationXref
id: F6WV79
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P04627 278
organism: Mus musculus

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot B1NA68 418
organism: Danio rerio

uniprot F6VWY6 591
type: UnificationXref
id: F6VWY6
db: uniprot

uniprot A8HAM3 380
type: UnificationXref
id: A8HAM3
db: uniprot

Serine/threonine-protein kinase ppk21
type: ProteinReference
xref: uniprot Q9Y7J6 259
xref: PTHR24356:SF163
organism: Schizosaccharomyces pombe

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

Phospholipase
type: ProteinReference
xref: uniprot H2R1L6 593
xref: PTHR18896:SF57
organism: Pan troglodytes

uniprot Q9JM73 389
type: UnificationXref
id: Q9JM73
db: uniprot

uniprot P46734 502
type: UnificationXref
id: P46734
db: uniprot

uniprot Q1LYG2 287
type: UnificationXref
id: Q1LYG2
db: uniprot

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot F1Q2Y3 253
organism: Canis lupus familiaris

uniprot P11233 179
type: UnificationXref
id: P11233
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5R9X3 428
xref: PTHR11801:SF18
organism: Macaca mulatta

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 280
xref: PTHR44329:SF22
xref: uniprot P05625 279
organism: Gallus gallus

GSK3
type: Protein
entity reference: GSK3
feature: GSK3 s65 a94 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05627 378
organism: Mus musculus

Protein C-ets-1
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot P27577 397
organism: Mus musculus

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q9DGD9 586
xref: PTHR24055:SF222
organism: Danio rerio

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot E2R9L4 70
organism: Canis lupus familiaris

uniprot O02812 319
type: UnificationXref
id: O02812
db: uniprot

Ral
type: ProteinReference
xref: P04550
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Ral
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Ral Synonym: Synonym not specified Accession: P04550
member entity reference: Ras-related protein Ral-A
member entity reference: AGAP012108-PA (Fragment)
member entity reference: Uncharacterized protein
member entity reference: Rala protein
member entity reference: V-ral simian leukemia viral oncogene homolog Ba (ras-related)
member entity reference: RALB protein
member entity reference: Ras-related protein Ral-B
member entity reference: V-ral simian leukemia viral oncogene homolog A (ras-related)
member entity reference: RALA isoform 2
member entity reference: Ras-related protein Ral-a
member entity reference: V-ral simian leukemia viral oncogene homolog A (Ras related)
member entity reference: V-ral simian leukemia viral oncogene homolog Ab (ras-related)
member entity reference: RAS like proto-oncogene B
member entity reference: RAS like proto-oncogene A

Ribosomal protein S6 kinase alpha-2
type: ProteinReference
xref: uniprot Q15349 41
xref: PTHR24351:SF213
organism: Homo sapiens

Ras-related C3 botulinum toxin substrate 3
type: ProteinReference
xref: PTHR24072:SF325
xref: uniprot H9EQ53 349
organism: Macaca mulatta

uniprot J9P1D8 594
type: UnificationXref
id: J9P1D8
db: uniprot

uniprot A0A2I3TN41 252
type: UnificationXref
id: A0A2I3TN41
db: uniprot

uniprot E2RP04 20
type: UnificationXref
id: E2RP04
db: uniprot

Ras-related protein Ral-A
type: ProteinReference
xref: uniprot F7GPM1 176
xref: PTHR24070:SF174
organism: Macaca mulatta

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot P11831 388
organism: Homo sapiens

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE1 332
organism: Danio rerio

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: uniprot Q9DGE2 333
xref: PTHR24055:SF110
organism: Danio rerio

PTHR24070:SF420
type: RelationshipXref
id: PTHR24070:SF420
db: PANTHER Family
relationship type: By Homology

p38
type: Protein
entity reference: p38
feature: ACTIVE 45
feature: p38 s105 a99 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

uniprot P32871 475
type: UnificationXref
id: P32871
db: uniprot

MAPKAP
type: Protein
entity reference: MAPKAP
feature: MAPKAP s54 a77 rs1
feature: MAPKAP s54 a77 rs2
feature: MAPKAP s54 a77 rs3
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P62746 630
type: UnificationXref
id: P62746
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot Q9DGE0 507
organism: Danio rerio

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O35904 473
xref: PTHR10048:SF35
organism: Mus musculus

uniprot P98083 650
type: UnificationXref
id: P98083
db: uniprot

Exocyst complex component 2
type: ProteinReference
xref: uniprot Q5RGD7 99
organism: Danio rerio

uniprot Q9T053 607
type: UnificationXref
id: Q9T053
db: uniprot

uniprot E2RJX4 537
type: UnificationXref
id: E2RJX4
db: uniprot

uniprot P04627 278
type: UnificationXref
id: P04627
db: uniprot

uniprot F7HI13 94
type: UnificationXref
id: F7HI13
db: uniprot

uniprot Q9D4H1 101
type: UnificationXref
id: Q9D4H1
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot D4A3T0 209
organism: Rattus norvegicus

Grb2 s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r23 739
type: Stoichiometry
physical entity: TAK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 738
type: Stoichiometry
physical entity: TAK
stoichiometric coefficient: 1.0

uniprot F1P859 212
type: UnificationXref
id: F1P859
db: uniprot

Signal transducer and activator of transcription 1-alpha/beta
type: ProteinReference
xref: PTHR11801:SF18
xref: uniprot P42224 437
organism: Homo sapiens

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot E2RIF9 453
organism: Canis lupus familiaris

uniprot F1PHV7 135
type: UnificationXref
id: F1PHV7
db: uniprot

AGAP002219-PA
type: ProteinReference
xref: uniprot Q7QK91 160
xref: PTHR24070:SF420
organism: Anopheles gambiae

uniprot P54675 482
type: UnificationXref
id: P54675
db: uniprot

uniprot Q3SYZ2 411
type: UnificationXref
id: Q3SYZ2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_Ral-RIGHT__GDP-_Ral-_r14
controller: RalGDS

uniprot D3Z8E0 18
type: UnificationXref
id: D3Z8E0
db: uniprot

uniprot Q8BTI9 485
type: UnificationXref
id: Q8BTI9
db: uniprot

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot F7EJU0 499
organism: Xenopus tropicalis

uniprot F6ZKB3 570
type: UnificationXref
id: F6ZKB3
db: uniprot

uniprot E1B847 69
type: UnificationXref
id: E1B847
db: uniprot

Ets
type: Protein
entity reference: Ets
feature: Ets s74 a105 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Ral guanine nucleotide dissociation stimulator-like 1
type: ProteinReference
xref: uniprot Q9NZL6 208
organism: Homo sapiens

JNK
type: Protein
entity reference: JNK
feature: ACTIVE 45
feature: JNK s43 a68 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7DKX6 620
type: UnificationXref
id: F7DKX6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2REH3 230
xref: PTHR48015:SF20
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r16
controller: Rac

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r15
controller: Cdc42

uniprot Q16539 328
type: UnificationXref
id: Q16539
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot P15153 350
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3U4 256
xref: PTHR24356:SF163
organism: Gallus gallus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 131

uniprot E2RIF9 453
type: UnificationXref
id: E2RIF9
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 98

uniprot F1PZ82 401
type: UnificationXref
id: F1PZ82
db: uniprot

Pristionchus pacificus
type: BioSource
xref: ncbitaxon 54126 520

uniprot Q69X21 604
type: UnificationXref
id: Q69X21
db: uniprot

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P42227 439
organism: Mus musculus

MEK s52 a74 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Signal transducer and activator of transcription 1
type: ProteinReference
xref: uniprot P42225 438
xref: PTHR11801:SF18
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q8BTI9 485
xref: PTHR10048:SF33
organism: Mus musculus

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 263
evidence: Evidence 265
evidence: Evidence 266
evidence: Evidence 264
xref: uniprot E2REI6 271
xref: PTHR44329:SF22
organism: Canis lupus familiaris

uniprot F1PXD3 495
type: UnificationXref
id: F1PXD3
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q07889 223
xref: PTHR23113:SF168
organism: Homo sapiens

V-ral simian leukemia viral oncogene homolog A (ras-related)
type: ProteinReference
xref: uniprot Q28CF3 184
xref: PTHR24070:SF174
organism: Xenopus tropicalis

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot F1M7N7 22
organism: Rattus norvegicus

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot O08911 320
xref: PTHR24055:SF146
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Stat_1_3-RIGHT__Stat_1_3-_r64
controller: JNK

uniprot H9EQ53 349
type: UnificationXref
id: H9EQ53
db: uniprot

uniprot P51136 118
type: UnificationXref
id: P51136
db: uniprot

MLK3
type: Protein
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P58500 612
type: UnificationXref
id: P58500
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot D4A3U7 310
organism: Rattus norvegicus

uniprot K7CZM1 220
type: UnificationXref
id: K7CZM1
db: uniprot

uniprot P08556 146
type: UnificationXref
id: P08556
db: uniprot

PARTICIPANT STOICHIOMETRY r29 727
type: Stoichiometry
physical entity: PLD
stoichiometric coefficient: 1.0

uniprot P15153 350
type: UnificationXref
id: P15153
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2R2N2 48
xref: PTHR24055:SF203
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r29 726
type: Stoichiometry
physical entity: PLD
stoichiometric coefficient: 1.0

GTP-binding protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot O93467 624
organism: Gallus gallus

uniprot Q6MGC5 207
type: UnificationXref
id: Q6MGC5
db: uniprot

GTP-binding protein
type: ProteinReference
xref: uniprot O93468 625
xref: PTHR24072:SF0
organism: Gallus gallus

uniprot Q28EW2 155
type: UnificationXref
id: Q28EW2
db: uniprot

uniprot Q07890 224
type: UnificationXref
id: Q07890
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot O09110 501
organism: Mus musculus

JNK s42 a65 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

uniprot P08134 626
type: UnificationXref
id: P08134
db: uniprot

PARTICIPANT STOICHIOMETRY r25 735
type: Stoichiometry
physical entity: p90RSK
stoichiometric coefficient: 1.0

Ras homolog family member A
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q28GJ8 634
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r25 734
type: Stoichiometry
physical entity: p90RSK
stoichiometric coefficient: 1.0

uniprot P15336 169
type: UnificationXref
id: P15336
db: uniprot

ERK
type: Protein
entity reference: ERK
feature: ERK s51 a72 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot E2R7W7 494
type: UnificationXref
id: E2R7W7
db: uniprot

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F1PBB6 419
organism: Canis lupus familiaris

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P32871 475
organism: Bos taurus

uniprot P11345 282
type: UnificationXref
id: P11345
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1M0G8 227
xref: PTHR48015:SF22
organism: Bos taurus

PI3K
type: Protein
entity reference: PI3K
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LSY0 226
xref: PTHR48015:SF30
organism: Bos taurus

uniprot Q6DGB7 365
type: UnificationXref
id: Q6DGB7
db: uniprot

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot E1BE66 451
xref: PTHR10048:SF35
organism: Bos taurus

SOS
type: Protein
entity reference: SOS
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot E2RB53 108
organism: Canis lupus familiaris

PTHR11801:SF18
type: RelationshipXref
id: PTHR11801:SF18
db: PANTHER Family
relationship type: By Homology

uniprot O08648 75
type: UnificationXref
id: O08648
db: uniprot

uniprot Q3T0F9 84
type: UnificationXref
id: Q3T0F9
db: uniprot

eco ECO:0000304 577
type: UnificationXref
id: ECO:0000304
db: eco

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot P32883 150
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot E2RMM5 617
organism: Canis lupus familiaris

uniprot A0A2I3T7A8 445
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

V-ral simian leukemia viral oncogene homolog A (Ras related)
type: ProteinReference
xref: PTHR24070:SF174
xref: uniprot Q3ZCK2 185
organism: Bos taurus

HETERODIMER_ASSOCIATION_LEFT__Growth_factor-_Growth_factor_receptor-RIGHT__Complex__Growth_Factor_Receptor_Growth_Factor_-_re55
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re55 677
participant stoichiometry: PARTICIPANT STOICHIOMETRY re55 675
participant stoichiometry: PARTICIPANT STOICHIOMETRY re55 676
left: Growth factor
left: Growth factor receptor
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Growth Factor Receptor/Growth Factor)

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal Reorganization
controller: Cdc42

ATF2
type: Protein
entity reference: ATF2
feature: ATF2 s75 a106 rs2
feature: ATF2 s75 a106 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1LWJ8 562
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

TAK
type: ProteinReference
xref: P04575
standard name: TGFbeta-activated kinase-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.TAK
comment: ENTITY_REFERENCE_NOTES= Long Name: TAK Synonym: Synonym not specified Accession: P04575
member entity reference: MAP3K7 C-terminal-like protein
member entity reference: Uncharacterized protein
member entity reference: MAP3K7 C-terminal-like

uniprot Q64303 249
type: UnificationXref
id: Q64303
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 341

uniprot P19073 521
type: UnificationXref
id: P19073
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F6YCI3 216
organism: Monodelphis domestica

PTHR24349:SF63
type: RelationshipXref
id: PTHR24349:SF63
db: PANTHER Family
relationship type: By Homology

PTHR24349:SF64
type: RelationshipXref
id: PTHR24349:SF64
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r63 718
type: Stoichiometry
physical entity: AP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 719
type: Stoichiometry
physical entity: AP1
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P45985 424
xref: PTHR48013:SF20
organism: Homo sapiens

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 576
xref: PTHR24055:SF222
organism: Homo sapiens

Ets s74 a105 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P45984 578
organism: Homo sapiens

Glycogen synthase kinase-3 beta isoform 1
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot H9EPM1 113
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK1_4-RIGHT__MEKK1_4-_r13
controller: Rac

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: uniprot Q3UMW7 412
xref: PTHR24349:SF64
organism: Mus musculus

Exocyst complex component 2
type: ProteinReference
xref: uniprot E1BDW9 90
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot F6PR50 71
organism: Macaca mulatta

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

uniprot Q6PF93 484
type: UnificationXref
id: Q6PF93
db: uniprot

uniprot Q16644 410
type: UnificationXref
id: Q16644
db: uniprot

uniprot A0A3Q2TY19 563
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P14056 284
organism: Rattus norvegicus

uniprot K7B6P4 199
type: UnificationXref
id: K7B6P4
db: uniprot

uniprot F7CDZ8 93
type: UnificationXref
id: F7CDZ8
db: uniprot

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 122

uniprot F6S876 23
type: UnificationXref
id: F6S876
db: uniprot

ncbitaxon 6945 514
type: UnificationXref
id: 6945
db: ncbitaxon

RALA isoform 2
type: ProteinReference
xref: uniprot H2QUG6 177
xref: PTHR24070:SF174
organism: Pan troglodytes

RalBP1
type: Protein
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot H2QMP5 406
type: UnificationXref
id: H2QMP5
db: uniprot

uniprot Q61193 206
type: UnificationXref
id: Q61193
db: uniprot

GTPase HRas
type: ProteinReference
xref: uniprot Q61411 158
xref: PTHR24070:SF385
organism: Mus musculus

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P08556 146
organism: Mus musculus

uniprot F7FP88 385
type: UnificationXref
id: F7FP88
db: uniprot

ERK s53 a76 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Cell division control protein 42
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot Q9HF56 533
organism: Ashbya gossypii

PTHR46001:SF1
type: RelationshipXref
id: PTHR46001:SF1
db: PANTHER Family
relationship type: By Homology

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MLK3-RIGHT__MLK3-_r24
controller: Ras

uniprot F6TKL3 567
type: UnificationXref
id: F6TKL3
db: uniprot

MAPKAP s54 a77 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8273977914520914
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q66H84 413
type: UnificationXref
id: Q66H84
db: uniprot

Ribosomal protein S6 kinase alpha-2
type: ProteinReference
xref: uniprot Q9WUT3 44
xref: PTHR24351:SF213
organism: Mus musculus

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F6UNV6 25
xref: PTHR24351:SF58
organism: Macaca mulatta

RalBP1
type: Protein
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7GPM1 176
type: UnificationXref
id: F7GPM1
db: uniprot

PTHR10048:SF7
type: RelationshipXref
id: PTHR10048:SF7
db: PANTHER Family
relationship type: By Homology

PTHR11801:SF2
type: RelationshipXref
id: PTHR11801:SF2
db: PANTHER Family
relationship type: By Homology

TAK
type: Protein
entity reference: TAK
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9NL43 121
type: UnificationXref
id: Q9NL43
db: uniprot

PARTICIPANT STOICHIOMETRY r13 689
type: Stoichiometry
physical entity: MEKK1/4
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RHD1 490
organism: Macaca mulatta

MAPKAP s54 a77 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5205801522987876
comment: MODIFICATION_RESIDUE_NAME=

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RJA0 231
xref: PTHR48015:SF22
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r13 688
type: Stoichiometry
physical entity: MEKK1/4
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot E2RB82 431
organism: Canis lupus familiaris

uniprot Q96KP1 100
type: UnificationXref
id: Q96KP1
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot Q9WV60 123
organism: Mus musculus

Raf
type: ProteinReference
xref: P04556
standard name: Raf Oncogene
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Raf Synonym: A-Raf,B-Raf,C-RAF,MAPKKK,MEKK,Mitogen activated protein kinase kinase kinase Accession: P04556
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Raf
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase B-raf
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: B-Raf proto-oncogene, serine/threonine kinase
member entity reference: A-Raf proto-oncogene, serine/threonine kinase
member entity reference: RAF proto-oncogene serine/threonine-protein kinase

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P10398 281
organism: Homo sapiens

uniprot A4FV00 564
type: UnificationXref
id: A4FV00
db: uniprot

PARTICIPANT STOICHIOMETRY r45 691
type: Stoichiometry
physical entity: Elk-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 690
type: Stoichiometry
physical entity: Elk-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 744
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 745
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

uniprot H2QST2 197
type: UnificationXref
id: H2QST2
db: uniprot

uniprot Q7T399 644
type: UnificationXref
id: Q7T399
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A3Q1MLN6 16
xref: PTHR24351:SF43
organism: Bos taurus

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot Q5E9X2 505
organism: Bos taurus

Ribosomal protein S6 kinase alpha-3
type: ProteinReference
xref: uniprot P18654 38
xref: PTHR24351:SF58
organism: Mus musculus

Ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot P18653 36
organism: Mus musculus

Ribosomal protein S6 kinase 2 alpha
type: ProteinReference
xref: uniprot P18652 34
xref: PTHR24351:SF43
organism: Gallus gallus

MAPKAP s54 a77 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.74176493209759

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot O88763 474
organism: Rattus norvegicus

Ras homolog family member Ca
type: ProteinReference
xref: uniprot Q7T399 644
xref: PTHR24072:SF329
organism: Danio rerio

STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r43
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 700
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 701
left: Ets
interaction type: STATE_TRANSITION
right: Ets

p90RSK
type: Protein
entity reference: p90RSK
feature: p90RSK s55 a78 rs2
feature: p90RSK s55 a78 rs1
feature: p90RSK s55 a78 rs3
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Tiam1
type: Protein
entity reference: Tiam1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6VAQ8 458
type: UnificationXref
id: F6VAQ8
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot P18266 115
organism: Rattus norvegicus

uniprot P62747 631
type: UnificationXref
id: P62747
db: uniprot

Glycogen synthase kinase-3 alpha
type: ProteinReference
xref: PTHR24057:SF14
xref: uniprot P18265 114
organism: Rattus norvegicus

Signal transducer and activator of transcription 3
type: ProteinReference
xref: uniprot Q6DV79 441
xref: PTHR11801:SF2
organism: Gallus gallus

Protein C-ets-1
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot P14921 396
organism: Homo sapiens

Protein CBR-CDC-42
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot A8XGW3 510
organism: Caenorhabditis briggsae

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P52631 440
organism: Rattus norvegicus

PTHR24055:SF238
type: RelationshipXref
id: PTHR24055:SF238
db: PANTHER Family
relationship type: By Homology

MKK4/7
type: Protein
entity reference: MKK4/7
feature: MKK4 7 s40 a63 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_r62
controller: p90RSK

PTHR24057:SF14
type: RelationshipXref
id: PTHR24057:SF14
db: PANTHER Family
relationship type: By Homology

uniprot Q6PC73 88
type: UnificationXref
id: Q6PC73
db: uniprot

MAP3K7 C-terminal-like protein
type: ProteinReference
xref: uniprot P57077 611
xref: PTHR47140:SF1
organism: Homo sapiens

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F7BYN4 433
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 717
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 716
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 720
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 721
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

uniprot H2R1L6 593
type: UnificationXref
id: H2R1L6
db: uniprot

Cdc42l protein
type: ProteinReference
xref: uniprot Q7ZUQ1 530
organism: Danio rerio

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1N7C3 211
xref: PTHR23113:SF168
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63085 59
xref: PTHR24055:SF203
organism: Mus musculus

STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 674
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 673
left: Rho
interaction type: STATE_TRANSITION
right: Rho

uniprot E2RLH2 616
type: UnificationXref
id: E2RLH2
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63086 60
xref: PTHR24055:SF203
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__p90RSK-RIGHT__p90RSK-_r25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 734
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 735
left: p90RSK
interaction type: STATE_TRANSITION
right: p90RSK

PAK
type: Protein
entity reference: PAK
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot P53778 325
xref: PTHR24055:SF146
organism: Homo sapiens

uniprot P40793 523
type: UnificationXref
id: P40793
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot P53779 581
organism: Homo sapiens

IDA
type: EvidenceCodeVocabulary

Phospholipase
type: ProteinReference
xref: uniprot F6VWY6 591
xref: PTHR18896:SF121
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_r62
controller: MAPKAP

uniprot Q13153 245
type: UnificationXref
id: Q13153
db: uniprot

uniprot P42225 438
type: UnificationXref
id: P42225
db: uniprot

Rac family small GTPase 1
type: ProteinReference
xref: uniprot Q6GL60 368
xref: PTHR24072:SF105
organism: Xenopus tropicalis

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

ATF2
type: Protein
entity reference: ATF2
feature: ATF2 s92 a112 rs1
feature: ACTIVE 45
feature: ATF2 s92 a112 rs2
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PTHR10048:SF109
type: RelationshipXref
id: PTHR10048:SF109
db: PANTHER Family
relationship type: By Homology

uniprot Q28HZ4 635
type: UnificationXref
id: Q28HZ4
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 263
evidence: Evidence 265
evidence: Evidence 266
evidence: Evidence 264
xref: PTHR44329:SF22
xref: uniprot F7BRK5 274
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q02750 301
xref: PTHR48013:SF5
organism: Homo sapiens

uniprot Q9HF56 533
type: UnificationXref
id: Q9HF56
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q62245 225
organism: Mus musculus

SOS
type: ProteinReference
xref: P04552
standard name: Son of sevenless
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.SOS
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Son of sevenless Synonym: SOS Accession: P04552
member entity reference: Son of sevenless homolog 1
member entity reference: Son of sevenless homolog 2
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: Protein son of sevenless
member entity reference: Uncharacterized protein

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot A0A2R8Q8S1 128
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATF2-RIGHT__ATF2-_r66
controller: JNK

uniprot E2RKA7 311
type: UnificationXref
id: E2RKA7
db: uniprot

PTHR24070:SF17
type: RelationshipXref
id: PTHR24070:SF17
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LWJ8 562
xref: PTHR24055:SF222
organism: Bos taurus

uniprot P63000 357
type: UnificationXref
id: P63000
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TNY5 429
xref: PTHR11801:SF18
organism: Pan troglodytes

Growth factor receptor-bound protein 2
type: ProteinReference
evidence: Evidence 89
xref: uniprot Q6PC73 88
xref: PTHR46037:SF4
organism: Danio rerio

uniprot Q5E9X2 505
type: UnificationXref
id: Q5E9X2
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 134

uniprot A0A3Q1LSJ2 68
type: UnificationXref
id: A0A3Q1LSJ2
db: uniprot

MAP2K4 isoform 3
type: ProteinReference
xref: uniprot H2QCA7 422
xref: PTHR48013:SF20
organism: Pan troglodytes

T-lymphoma invasion and metastasis-inducing protein 1
type: ProteinReference
xref: PTHR46001:SF1
xref: uniprot Q13009 557
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot W4Y0P1 125
organism: Strongylocentrotus purpuratus

Ral guanine nucleotide dissociation stimulator-like 2
type: ProteinReference
xref: uniprot Q61193 206
xref: PTHR23113:SF213
organism: Mus musculus

TAK
type: Protein
entity reference: TAK
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6PGQ1 110
type: UnificationXref
id: F6PGQ1
db: uniprot

GTPase HRas isoform 1
type: ProteinReference
xref: uniprot F7F5K9 140
xref: PTHR24070:SF385
organism: Macaca mulatta

Ral guanine nucleotide dissociation stimulator-like 2
type: ProteinReference
xref: PTHR23113:SF213
xref: uniprot F1PS09 194
organism: Canis lupus familiaris

Ral guanine nucleotide dissociation stimulator
type: ProteinReference
xref: uniprot Q03385 201
xref: PTHR23113:SF35
organism: Mus musculus

uniprot A0A2I3TRY9 446
type: UnificationXref
id: A0A2I3TRY9
db: uniprot

Ral guanine nucleotide dissociation stimulator
type: ProteinReference
xref: PTHR23113:SF35
xref: uniprot Q03386 202
organism: Rattus norvegicus

Growth factor receptor
type: Protein
feature: Growth factor receptor s4 sa4 rs1
feature: ACTIVE 45

uniprot Q6RUV5 370
type: UnificationXref
id: Q6RUV5
db: uniprot

uniprot P05625 279
type: UnificationXref
id: P05625
db: uniprot

uniprot A0A3Q1LXK8 15
type: UnificationXref
id: A0A3Q1LXK8
db: uniprot

Glycogen synthase kinase
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot Q9NL43 121
organism: Ciona intestinalis

Zgc:55558
type: ProteinReference
xref: PTHR24070:SF392
xref: uniprot Q7ZUL8 162
organism: Danio rerio

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F6S876 23
xref: PTHR24351:SF43
organism: Xenopus tropicalis

uniprot Q9XF67 257
type: UnificationXref
id: Q9XF67
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot F7A567 518
organism: Monodelphis domestica

uniprot Q22706 97
type: UnificationXref
id: Q22706
db: uniprot

Cdc42 homolog
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot Q17031 527
organism: Anopheles gambiae

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K344 442
organism: Rattus norvegicus

uniprot E9FRC3 344
type: UnificationXref
id: E9FRC3
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Vesicle Trafficking
controller: Sec5

uniprot O35904 473
type: UnificationXref
id: O35904
db: uniprot

ncbitaxon 6238 131
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot A0A2I3TK00 268
type: UnificationXref
id: A0A2I3TK00
db: uniprot

uniprot P49187 580
type: UnificationXref
id: P49187
db: uniprot

Cdc42
type: Protein
entity reference: Cdc42
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6SFG7 137
type: UnificationXref
id: F6SFG7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1Q3M8 455
xref: PTHR10048:SF107
organism: Canis lupus familiaris

uniprot P36506 298
type: UnificationXref
id: P36506
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38-RIGHT__p38-_r37
controller: MKK3/6

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

uniprot A0A2I3TF56 391
type: UnificationXref
id: A0A2I3TF56
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZIF0 304
xref: PTHR48013:SF5
organism: Gallus gallus

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot P35465 243
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot H9FVU5 471
organism: Macaca mulatta

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

uniprot O00329 472
type: UnificationXref
id: O00329
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot P36507 299
xref: PTHR48013:SF8
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36506 298
organism: Rattus norvegicus

uniprot H2QY37 198
type: UnificationXref
id: H2QY37
db: uniprot

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TAK-RIGHT__TAK-_r23
controller: Ras

uniprot Q7ZUL8 162
type: UnificationXref
id: Q7ZUL8
db: uniprot

Phospholipase D
type: ProteinReference
xref: uniprot Q69X21 604
xref: PTHR18896:SF59
organism: Oryza sativa

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Phospholipase D
type: ProteinReference
xref: uniprot Q69X22 605
xref: PTHR18896:SF59
organism: Oryza sativa

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

uniprot A8XGW3 510
type: UnificationXref
id: A8XGW3
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 449
organism: Rattus norvegicus

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F6Y841 461
organism: Canis lupus familiaris

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 154

Cdc42hs complexed with A peptide derived from P-21 activated kinase
type: ProteinReference
xref: uniprot B3S037 511
xref: PTHR24072:SF192
organism: Trichoplax adhaerens

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

uniprot F6SW23 456
type: UnificationXref
id: F6SW23
db: uniprot

uniprot F6V946 273
type: UnificationXref
id: F6V946
db: uniprot

uniprot P62999 356
type: UnificationXref
id: P62999
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P62999 356
xref: PTHR24072:SF105
organism: Canis lupus familiaris

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P62998 355
xref: PTHR24072:SF105
organism: Bos taurus

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot P62993 82
xref: PTHR46037:SF4
organism: Homo sapiens

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot P62994 83
xref: PTHR46037:SF4
organism: Rattus norvegicus

GSK3 s65 a94 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6SW23 456
organism: Gallus gallus

uniprot A0A3Q1LNQ6 13
type: UnificationXref
id: A0A3Q1LNQ6
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot F6ZM84 462
organism: Xenopus tropicalis

Ral guanine nucleotide dissociation stimulator-like 1
type: ProteinReference
xref: uniprot F7FZA2 196
organism: Macaca mulatta

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q9WUI1 336
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot Q9Y6R4 79
xref: PTHR48016:SF32
organism: Homo sapiens

Ras-related C3 botulinum toxin substrate 3
type: ProteinReference
xref: PTHR24072:SF325
xref: uniprot P60764 354
organism: Mus musculus

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60766 524
organism: Mus musculus

Ras-related C3 botulinum toxin substrate 3
type: ProteinReference
xref: PTHR24072:SF325
xref: uniprot P60763 353
organism: Homo sapiens

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q5M824 652
xref: PTHR10337:SF2
organism: Rattus norvegicus

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q9XF67 257
xref: PTHR24356:SF163
organism: Arabidopsis thaliana

uniprot Q00969 171
type: UnificationXref
id: Q00969
db: uniprot

uniprot P42336 476
type: UnificationXref
id: P42336
db: uniprot

uniprot E2RMM5 617
type: UnificationXref
id: E2RMM5
db: uniprot

MKK4/7
type: Protein
entity reference: MKK4/7
feature: ACTIVE 45
feature: MKK4 7 s41 a64 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 66
organism: Danio rerio

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 522

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F6URW3 215
organism: Ornithorhynchus anatinus

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 103

uniprot Q6GL60 368
type: UnificationXref
id: Q6GL60
db: uniprot

Rho-related GTP-binding protein RhoA-D
type: ProteinReference
xref: uniprot Q6DHE8 639
xref: PTHR24072:SF329
organism: Danio rerio

uniprot Q9DGE1 332
type: UnificationXref
id: Q9DGE1
db: uniprot

PTHR18896:SF59
type: RelationshipXref
id: PTHR18896:SF59
db: PANTHER Family
relationship type: By Homology

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F6UWI0 26
xref: PTHR24351:SF213
organism: Canis lupus familiaris

RGL2 isoform 1
type: ProteinReference
xref: PTHR23113:SF213
xref: uniprot H2QST2 197
organism: Pan troglodytes

PTHR18896:SF57
type: RelationshipXref
id: PTHR18896:SF57
db: PANTHER Family
relationship type: By Homology

Rho
type: Protein
entity reference: Rho
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 668
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 667
left: Cdc42
interaction type: STATE_TRANSITION
right: Cdc42

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 560
xref: PTHR24055:SF162
organism: Gallus gallus

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot P53349 76
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2TVV5 106
xref: PTHR24057:SF8
organism: Gallus gallus

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot F7ACT4 111
organism: Xenopus tropicalis

Cell division control protein 42
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot P19073 521
organism: Saccharomyces cerevisiae

uniprot E1BJP4 382
type: UnificationXref
id: E1BJP4
db: uniprot

Ets
type: Protein
entity reference: Ets
feature: Ets s86 a111 rs1
feature: ACTIVE 45
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q66JE6 306
xref: PTHR48013:SF5
organism: Xenopus tropicalis

PTHR19304:SF9
type: RelationshipXref
id: PTHR19304:SF9
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 64
organism: Danio rerio

uniprot Q12526 153
type: UnificationXref
id: Q12526
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: uniprot P29353 649
xref: PTHR10337:SF2
organism: Homo sapiens

uniprot F6W7C8 460
type: UnificationXref
id: F6W7C8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1P630 565
xref: PTHR24055:SF172
organism: Canis lupus familiaris

uniprot P14921 396
type: UnificationXref
id: P14921
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TQ88 430
xref: PTHR11801:SF2
organism: Pan troglodytes

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 24

uniprot A0A2J8QY32 447
type: UnificationXref
id: A0A2J8QY32
db: uniprot

uniprot F1NCY7 400
type: UnificationXref
id: F1NCY7
db: uniprot

Ras-related protein Ral-B
type: ProteinReference
xref: PTHR24070:SF199
xref: uniprot P11234 180
organism: Homo sapiens

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q8CFN2 531
xref: PTHR24072:SF136
organism: Rattus norvegicus

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q1RMJ6 632
organism: Bos taurus

uniprot A0A3Q1MLN6 16
type: UnificationXref
id: A0A3Q1MLN6
db: uniprot

uniprot Q9N272 334
type: UnificationXref
id: Q9N272
db: uniprot

Ras-related protein Ral-A
type: ProteinReference
xref: uniprot P11233 179
xref: PTHR24070:SF174
organism: Homo sapiens

Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot Q66JH1 159
organism: Xenopus tropicalis

uniprot P52631 440
type: UnificationXref
id: P52631
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2R0G7 575
xref: PTHR24055:SF222
organism: Pan troglodytes

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q62159 638
organism: Mus musculus

uniprot P70496 597
type: UnificationXref
id: P70496
db: uniprot

uniprot P11234 180
type: UnificationXref
id: P11234
db: uniprot

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: uniprot Q61036 247
xref: PTHR48015:SF30
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r15 680
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 681
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot F6VAQ8 458
organism: Ornithorhynchus anatinus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Proliferation
controller: Cdc42

uniprot P16951 170
type: UnificationXref
id: P16951
db: uniprot

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot Q925D6 506
organism: Rattus norvegicus

uniprot K7BNT4 595
type: UnificationXref
id: K7BNT4
db: uniprot

Phospholipase D2
type: ProteinReference
xref: PTHR18896:SF121
xref: uniprot P70498 598
organism: Rattus norvegicus

Phospholipase D1
type: ProteinReference
xref: uniprot P70496 597
xref: PTHR18896:SF57
organism: Rattus norvegicus

uniprot Q9WUA6 550
type: UnificationXref
id: Q9WUA6
db: uniprot

uniprot A5D7R9 129
type: UnificationXref
id: A5D7R9
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A2I3T7A8 445
organism: Pan troglodytes

uniprot A0A3Q1LJZ7 308
type: UnificationXref
id: A0A3Q1LJZ7
db: uniprot

uniprot P48554 352
type: UnificationXref
id: P48554
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P49186 579
organism: Rattus norvegicus

uniprot P42227 439
type: UnificationXref
id: P42227
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6TKL3 567
organism: Xenopus tropicalis

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot P49187 580
organism: Rattus norvegicus

ncbitaxon 3702 258
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot F6TXC2 313
type: UnificationXref
id: F6TXC2
db: uniprot

uniprot F7FH99 348
type: UnificationXref
id: F7FH99
db: uniprot

uniprot P63085 59
type: UnificationXref
id: P63085
db: uniprot

uniprot F6YJ34 29
type: UnificationXref
id: F6YJ34
db: uniprot

uniprot F6V2V1 27
type: UnificationXref
id: F6V2V1
db: uniprot

uniprot F1QNG4 136
type: UnificationXref
id: F1QNG4
db: uniprot

Raf
type: Protein
entity reference: Raf
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

SRF isoform 1
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot K7D2P2 387
organism: Pan troglodytes

ncbitaxon 7668 126
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot Q0V8L6 600
type: UnificationXref
id: Q0V8L6
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal Reorganization
controller: Rac

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F6SFG7 137
organism: Macaca mulatta

PTHR24057:SF0
type: RelationshipXref
id: PTHR24057:SF0
db: PANTHER Family
relationship type: By Homology

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

Tiam1
type: Protein
entity reference: Tiam1
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

PTHR48013:SF17
type: RelationshipXref
id: PTHR48013:SF17
db: PANTHER Family
relationship type: By Homology

Elk 1 s89 a118 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8050345804348424
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 548
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F1N8W8 232
organism: Gallus gallus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 14

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9WUA6 550
organism: Mus musculus

uniprot D3ZHH8 381
type: UnificationXref
id: D3ZHH8
db: uniprot

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot P49138 409
organism: Mus musculus

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot P49137 408
organism: Homo sapiens

uniprot P57077 611
type: UnificationXref
id: P57077
db: uniprot

uniprot O93602 168
type: UnificationXref
id: O93602
db: uniprot

PTHR48013:SF21
type: RelationshipXref
id: PTHR48013:SF21
db: PANTHER Family
relationship type: By Homology

PTHR48013:SF20
type: RelationshipXref
id: PTHR48013:SF20
db: PANTHER Family
relationship type: By Homology

GRB2 isoform 3
type: ProteinReference
xref: uniprot G2HGD2 81
xref: PTHR46037:SF4
organism: Pan troglodytes

Rac-like GTP-binding protein ARAC2
type: ProteinReference
xref: PTHR24072:SF300
xref: uniprot Q38903 361
organism: Arabidopsis thaliana

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31749 547
xref: PTHR24356:SF171
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r15
controller: Rho

uniprot A9JRY8 339
type: UnificationXref
id: A9JRY8
db: uniprot

ncbitaxon 559292 522
type: UnificationXref
id: 559292
db: ncbitaxon

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 658
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A2I3TPM9 12
xref: PTHR24351:SF43
organism: Pan troglodytes

uniprot H2PXY8 469
type: UnificationXref
id: H2PXY8
db: uniprot

PI3K
type: Protein
entity reference: PI3K
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2R8Q8S1 128
type: UnificationXref
id: A0A2R8Q8S1
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 514

Glycogen synthase kinase-3
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot P51136 118
organism: Dictyostelium discoideum

uniprot H2PZQ7 142
type: UnificationXref
id: H2PZQ7
db: uniprot

Rho-related GTP-binding protein RhoA-B
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q6DHM9 640
organism: Danio rerio

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot F1PZ82 401
organism: Canis lupus familiaris

uniprot Q9T052 606
type: UnificationXref
id: Q9T052
db: uniprot

Rac-like GTP-binding protein ARAC4
type: ProteinReference
xref: uniprot Q38919 362
xref: PTHR24072:SF309
organism: Arabidopsis thaliana

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot Q08E52 244
xref: PTHR48015:SF20
organism: Bos taurus

uniprot F7ACT4 111
type: UnificationXref
id: F7ACT4
db: uniprot

Elk 1 s89 a118 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.458697954198361

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 5

STATE_TRANSITION_LEFT__TAK-RIGHT__TAK-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 739
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 738
left: TAK
interaction type: STATE_TRANSITION
right: TAK

Ras homolog family member B
type: ProteinReference
xref: uniprot Q6NVL3 642
xref: PTHR24072:SF0
organism: Xenopus tropicalis

Cdc42
type: ProteinReference
xref: P04569
standard name: Cell division cycle 42
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Cdc42 Synonym: Synonym not specified Accession: P04569
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Cdc42
member entity reference: Cdc42 protein, putative
member entity reference: Predicted protein
member entity reference: Cell division control protein 42
member entity reference: Uncharacterized protein
member entity reference: Cdc42 homolog
member entity reference: Cell division cycle 42
member entity reference: Cell division control protein 42 homolog
member entity reference: Cell division control protein 42 homolog isoform 2
member entity reference: Cdc42l protein
member entity reference: Cdc42hs complexed with A peptide derived from P-21 activated kinase
member entity reference: Protein CBR-CDC-42

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot E9HL06 618
organism: Daphnia pulex

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK3_6-RIGHT__MKK3_6-_r36
controller: MLK3

Serum response factor
type: ProteinReference
xref: uniprot F1PH12 383
xref: PTHR48019:SF40
organism: Canis lupus familiaris

Rac family small GTPase 1a
type: ProteinReference
xref: uniprot Q7ZSZ9 373
xref: PTHR24072:SF105
organism: Danio rerio

uniprot P60766 524
type: UnificationXref
id: P60766
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot H9FU32 275
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F7F5X1 141
organism: Monodelphis domestica

SRF s77 a108 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SRF
type: Protein
entity reference: SRF
feature: ACTIVE 45
feature: SRF s108 a115 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F1P630 565
type: UnificationXref
id: F1P630
db: uniprot

Survival
type: Pathway

uniprot P28482 58
type: UnificationXref
id: P28482
db: uniprot

uniprot P18266 115
type: UnificationXref
id: P18266
db: uniprot

uniprot Q9UK32 43
type: UnificationXref
id: Q9UK32
db: uniprot

uniprot F7GN93 573
type: UnificationXref
id: F7GN93
db: uniprot

uniprot F7G3I5 466
type: UnificationXref
id: F7G3I5
db: uniprot

RALGDS isoform 4
type: ProteinReference
xref: PTHR23113:SF35
xref: uniprot H2QY37 198
organism: Pan troglodytes

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot E2RCV1 452
organism: Canis lupus familiaris

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Survival
controller: SRF

ATF2 s92 a112 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.865087513468231
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: uniprot Q15418 42
xref: PTHR24351:SF43
organism: Homo sapiens

ncbitaxon 13616 30
type: UnificationXref
id: 13616
db: ncbitaxon

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q5F352 157
organism: Gallus gallus

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot Q02384 222
organism: Mus musculus

STATE_TRANSITION_LEFT__Elk_1-RIGHT__Elk_1-_r45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 690
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 691
left: Elk-1
interaction type: STATE_TRANSITION
right: Elk-1

STATE_TRANSITION_LEFT__MAPKAP-RIGHT__MAPKAP-_r30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 722
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 723
left: MAPKAP
interaction type: STATE_TRANSITION
right: MAPKAP

uniprot F6PR50 71
type: UnificationXref
id: F6PR50
db: uniprot

uniprot E2R0M7 554
type: UnificationXref
id: E2R0M7
db: uniprot

uniprot P49138 409
type: UnificationXref
id: P49138
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot H2QP14 240
xref: PTHR48015:SF22
organism: Pan troglodytes

uniprot F7BRK5 274
type: UnificationXref
id: F7BRK5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r3
controller: Ras

uniprot E7EXT6 538
type: UnificationXref
id: E7EXT6
db: uniprot

uniprot Q12967 204
type: UnificationXref
id: Q12967
db: uniprot

uniprot Q7T2F2 414
type: UnificationXref
id: Q7T2F2
db: uniprot

ATF2 s92 a112 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.491344174153594
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F6R8N3 542
organism: Macaca mulatta

JNK
type: ProteinReference
xref: P04572
standard name: Jun kinase n-terminal kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.JNK
comment: ENTITY_REFERENCE_NOTES= Long Name: Jun kinase n-terminal kinase Synonym: JNK,SAPK,stress activated protein kinase Accession: P04572
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Stress-activated protein kinase JNK

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6VXG1 459
organism: Xenopus tropicalis

uniprot O93468 625
type: UnificationXref
id: O93468
db: uniprot

Rho
type: Protein
entity reference: Rho
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A4GTP4 588
type: UnificationXref
id: A4GTP4
db: uniprot

uniprot Q9Y7J6 259
type: UnificationXref
id: Q9Y7J6
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Survival
controller: Elk-1

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot F6ZM17 31
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF17
xref: uniprot F7D0A6 421
organism: Monodelphis domestica

uniprot Q62245 225
type: UnificationXref
id: Q62245
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 367

uniprot P40763 436
type: UnificationXref
id: P40763
db: uniprot

PARTICIPANT STOICHIOMETRY r19 663
type: Stoichiometry
physical entity: MKK4/7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 664
type: Stoichiometry
physical entity: MKK4/7
stoichiometric coefficient: 1.0

uniprot F7GWI2 239
type: UnificationXref
id: F7GWI2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q5F337 363
organism: Gallus gallus

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot P01116 145
organism: Homo sapiens

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P01111 143
organism: Homo sapiens

uniprot D4A3T0 209
type: UnificationXref
id: D4A3T0
db: uniprot

GTPase HRas
type: ProteinReference
xref: uniprot P01112 144
xref: PTHR24070:SF385
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Z879 420
xref: PTHR48013:SF15
organism: Monodelphis domestica

uniprot P36507 299
type: UnificationXref
id: P36507
db: uniprot

PTHR24070:SF392
type: RelationshipXref
id: PTHR24070:SF392
db: PANTHER Family
relationship type: By Homology

T-lymphoma invasion and metastasis-inducing protein 1
type: ProteinReference
xref: PTHR46001:SF1
xref: uniprot A0A1D5QQD3 552
organism: Macaca mulatta

ATF2
type: ProteinReference
xref: P04548
standard name: Activating transcription factor 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.ATF2
comment: ENTITY_REFERENCE_NOTES= Long Name: Activating transcription factor 2 Synonym: Synonym not specified Accession: P04548
member entity reference: Cyclic AMP-dependent transcription factor ATF-2
member entity reference: Activating transcription factor 2

uniprot O14939 596
type: UnificationXref
id: O14939
db: uniprot

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

uniprot Q5F3U4 256
type: UnificationXref
id: Q5F3U4
db: uniprot

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A2I3RZ31 561
organism: Pan troglodytes

Growth factor
type: Protein
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot F7DKX6 620
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QAU9 415
xref: PTHR48013:SF15
organism: Macaca mulatta

Growth factor s5 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Growth factor
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot E2RLH2 616
organism: Canis lupus familiaris

uniprot D3ZWV8 553
type: UnificationXref
id: D3ZWV8
db: uniprot

uniprot A0A2I3TQ88 430
type: UnificationXref
id: A0A2I3TQ88
db: uniprot

Cell division cycle 42
type: ProteinReference
xref: PTHR24072:SF337
xref: uniprot Q52WY2 529
organism: Danio rerio

uniprot Q503B6 156
type: UnificationXref
id: Q503B6
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q91Y86 585
xref: PTHR24055:SF222
organism: Mus musculus

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot P52564 503
organism: Homo sapiens

PTHR24072:SF337
type: RelationshipXref
id: PTHR24072:SF337
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9WTY9 335
organism: Rattus norvegicus

uniprot A0A1D5R9U8 262
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

Sec5
type: Protein
entity reference: Sec5
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

AGAP005445-PA
type: ProteinReference
xref: uniprot Q7PNL6 372
xref: PTHR24072:SF281
organism: Anopheles gambiae

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot H2R8U9 218
organism: Pan troglodytes

ERK
type: Protein
entity reference: ERK
feature: ACTIVE 45
feature: ERK s53 a76 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot F7AGV5 497
organism: Monodelphis domestica

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 512

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

uniprot F7AKA6 72
type: UnificationXref
id: F7AKA6
db: uniprot

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

uniprot F6QUW1 214
type: UnificationXref
id: F6QUW1
db: uniprot

Phospholipase D alpha 1
type: ProteinReference
xref: uniprot Q38882 602
organism: Arabidopsis thaliana

STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 745
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 744
left: JNK
interaction type: STATE_TRANSITION
right: JNK

PTHR24072:SF329
type: RelationshipXref
id: PTHR24072:SF329
db: PANTHER Family
relationship type: By Homology

PTHR24072:SF325
type: RelationshipXref
id: PTHR24072:SF325
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot F7H9J1 73
organism: Macaca mulatta

Ras homolog family member B
type: ProteinReference
xref: uniprot F7FR08 622
xref: PTHR24072:SF0
organism: Ornithorhynchus anatinus

Complex (Growth Factor Receptor/Growth Factor)
type: Complex
component stoichiometry: Growth factor s5 sa5 STOICHIOMETRY ID COMPLEX
component: Growth factor receptor
component: Growth factor
feature: COMPLEX BINDING FEATURE s100 a120 661
feature: COMPLEX BINDING FEATURE s100 a120 659
cellular location: plasma membrane

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot F6PGQ1 110
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 710
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 711
left: AKT
interaction type: STATE_TRANSITION
right: AKT

uniprot H3FK05 519
type: UnificationXref
id: H3FK05
db: uniprot

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q9PSX7 645
organism: Gallus gallus

Sec5
type: Protein
entity reference: Sec5
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P49071 407
type: UnificationXref
id: P49071
db: uniprot

Rac family small GTPase 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q5U1Y2 364
organism: Rattus norvegicus

uniprot P35465 243
type: UnificationXref
id: P35465
db: uniprot

ncbitaxon 284812 260
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot P18653 36
type: UnificationXref
id: P18653
db: uniprot

uniprot F7EVK3 167
type: UnificationXref
id: F7EVK3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p90RSK-RIGHT__p90RSK-_r25
controller: ERK

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r14 685
type: Stoichiometry
physical entity: Ral
stoichiometric coefficient: 1.0

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q0IIE2 651
xref: PTHR10337:SF2
organism: Bos taurus

uniprot F7C798 317
type: UnificationXref
id: F7C798
db: uniprot

PARTICIPANT STOICHIOMETRY r14 684
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot F6THF0 345
type: UnificationXref
id: F6THF0
db: uniprot

PARTICIPANT STOICHIOMETRY r14 687
type: Stoichiometry
physical entity: Ral
stoichiometric coefficient: 1.0

PTHR24072:SF310
type: RelationshipXref
id: PTHR24072:SF310
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r14 686
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PAK
type: Protein
entity reference: PAK
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 260

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 534

uniprot F6R8N3 542
type: UnificationXref
id: F6R8N3
db: uniprot

Ets s86 a111 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q7ZUQ1 530
type: UnificationXref
id: Q7ZUQ1
db: uniprot

uniprot A0A3Q2U4X3 536
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Elk_1-RIGHT__Elk_1-_r45
controller: p38

uniprot Q1HG70 303
type: UnificationXref
id: Q1HG70
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O02812 319
xref: PTHR24055:SF110
organism: Canis lupus familiaris

uniprot P48736 479
type: UnificationXref
id: P48736
db: uniprot

uniprot P52564 503
type: UnificationXref
id: P52564
db: uniprot

MKK3 6 s67 a97 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q69X22 605
type: UnificationXref
id: Q69X22
db: uniprot

SOS s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

uniprot E2RJA0 231
type: UnificationXref
id: E2RJA0
db: uniprot

GDP
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F1MX38 432
organism: Bos taurus

uniprot E1BDW9 90
type: UnificationXref
id: E1BDW9
db: uniprot

PARTICIPANT STOICHIOMETRY r32 716
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

Evidence 289
type: Evidence
evidence code: IDA
comment: SPACC Q99N57

PARTICIPANT STOICHIOMETRY r32 717
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

Phospholipase D1
type: ProteinReference
xref: PTHR18896:SF57
xref: uniprot Q13393 601
organism: Homo sapiens

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot P19419 589
xref: PTHR11849:SF178
organism: Homo sapiens

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

Growth factor receptor
type: Complex
component stoichiometry: Growth factor receptor s4 sa4 STOICHIOMETRY ID COMPLEX
component: Growth factor receptor
feature: ACTIVE 45
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa4 660
cellular location: plasma membrane

uniprot F7CU42 237
type: UnificationXref
id: F7CU42
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot Q9WTU6 587
organism: Mus musculus

Shc
type: Protein
entity reference: Shc
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 654
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Phospholipase
type: ProteinReference
xref: PTHR18896:SF57
xref: uniprot F7FFF4 592
organism: Macaca mulatta

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 126

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9N272 334
xref: PTHR24055:SF107
organism: Pan troglodytes

ncbitaxon 39947 367
type: UnificationXref
id: 39947
db: ncbitaxon

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot H2R5K3 74
xref: PTHR24361:SF414
organism: Pan troglodytes

uniprot Q9Z1L0 489
type: UnificationXref
id: Q9Z1L0
db: uniprot

uniprot F7G4D2 386
type: UnificationXref
id: F7G4D2
db: uniprot

PTHR23113:SF35
type: RelationshipXref
id: PTHR23113:SF35
db: PANTHER Family
relationship type: By Homology

uniprot Q7ZSZ9 373
type: UnificationXref
id: Q7ZSZ9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot F6TXC2 313
organism: Monodelphis domestica

uniprot C3ZIB9 515
type: UnificationXref
id: C3ZIB9
db: uniprot

uniprot Q90694 532
type: UnificationXref
id: Q90694
db: uniprot

Elk-1
type: ProteinReference
xref: P04573
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Elk-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Elk-1 Synonym: Synonym not specified Accession: P04573
member entity reference: ETS domain-containing protein Elk-1

uniprot F1Q2Y3 253
type: UnificationXref
id: F1Q2Y3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot F7CS91 619
organism: Monodelphis domestica

AP1
type: Protein
entity reference: AP1
feature: AP1 s76 a107 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F6S9S9 293
organism: Monodelphis domestica

uniprot O55173 255
type: UnificationXref
id: O55173
db: uniprot

PARTICIPANT STOICHIOMETRY r16 674
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

ncbitaxon 227321 154
type: UnificationXref
id: 227321
db: ncbitaxon

MLK3
type: Protein
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r16 673
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

uniprot F7FH70 395
type: UnificationXref
id: F7FH70
db: uniprot

uniprot F7HPR8 647
type: UnificationXref
id: F7HPR8
db: uniprot

uniprot A0A3Q2UBK0 17
type: UnificationXref
id: A0A3Q2UBK0
db: uniprot

uniprot P60763 353
type: UnificationXref
id: P60763
db: uniprot

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

Ral guanine nucleotide dissociation stimulator-like 2
type: ProteinReference
xref: PTHR23113:SF213
xref: uniprot O15211 200
organism: Homo sapiens

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot F6V946 273
organism: Xenopus tropicalis

uniprot A0A3Q1M353 269
type: UnificationXref
id: A0A3Q1M353
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LTT9 309
xref: PTHR24055:SF110
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot A0A1D5QUZ8 46
organism: Macaca mulatta

p38
type: ProteinReference
xref: P04558
standard name: p38 mitogen activated protein kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: p38 mitogen activated protein kinase Synonym: p38,p38MAPK Accession: P04558
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.p38
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase p38b
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase 14A
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Mitogen-activated protein kinase 14B

uniprot F6TVC3 195
type: UnificationXref
id: F6TVC3
db: uniprot

uniprot Q8CIN4 251
type: UnificationXref
id: Q8CIN4
db: uniprot

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 119

uniprot A5D977 173
type: UnificationXref
id: A5D977
db: uniprot

uniprot E2REI6 271
type: UnificationXref
id: E2REI6
db: uniprot

PARTICIPANT STOICHIOMETRY r5 671
type: Stoichiometry
physical entity: Tiam1
stoichiometric coefficient: 1.0

uniprot Q3T0N5 329
type: UnificationXref
id: Q3T0N5
db: uniprot

PARTICIPANT STOICHIOMETRY r5 672
type: Stoichiometry
physical entity: Tiam1
stoichiometric coefficient: 1.0

uniprot F1PMN2 566
type: UnificationXref
id: F1PMN2
db: uniprot

uniprot F7FZA2 196
type: UnificationXref
id: F7FZA2
db: uniprot

uniprot P10398 281
type: UnificationXref
id: P10398
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q05144 359
organism: Mus musculus

Serum response factor a
type: ProteinReference
xref: uniprot A8HAM3 380
xref: PTHR48019:SF40
organism: Danio rerio

uniprot Q38919 362
type: UnificationXref
id: Q38919
db: uniprot

uniprot Q02384 222
type: UnificationXref
id: Q02384
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Elk_1-RIGHT__Elk_1-_r45
controller: ERK

T cell lymphoma invasion and metastasis 1
type: ProteinReference
xref: PTHR46001:SF1
xref: uniprot G3MXA5 555
organism: Bos taurus

Evidence 277
type: Evidence
evidence code: IDA
comment: SPACC P04049

Shc
type: ProteinReference
xref: P04579
standard name: SH2 homology domain containing transforming protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.Shc
comment: ENTITY_REFERENCE_NOTES= Long Name: Shc Synonym: Synonym not specified Accession: P04579
member entity reference: SHC (Src homology 2 domain containing) transforming protein 1
member entity reference: SHC-transforming protein 1
member entity reference: Uncharacterized protein

uniprot F1NYZ2 292
type: UnificationXref
id: F1NYZ2
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 509

uniprot P18654 38
type: UnificationXref
id: P18654
db: uniprot

uniprot A0A3Q1LQK4 448
type: UnificationXref
id: A0A3Q1LQK4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7BD74 498
organism: Monodelphis domestica

uniprot D4A5Q1 450
type: UnificationXref
id: D4A5Q1
db: uniprot

MAP3K7 C-terminal-like protein
type: ProteinReference
xref: uniprot P58500 612
xref: PTHR47140:SF1
organism: Mus musculus

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__PDK-RIGHT__PDK-_r33
controller: Pip3

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r21
controller: Raf

Rho-related GTP-binding protein RhoA-C
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q7T2E8 643
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y1Z2 394
xref: PTHR11849:SF209
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Elk_1-RIGHT__Elk_1-_r45
controller: JNK

Evidence 283
type: Evidence
evidence code: IDA
comment: SPACC P11345

uniprot A0A2I3T9Y4 535
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

uniprot F6YFT0 347
type: UnificationXref
id: F6YFT0
db: uniprot

Evidence 280
type: Evidence
evidence code: IDA
comment: SPACC P05625

uniprot Q13009 557
type: UnificationXref
id: Q13009
db: uniprot

ncbitaxon 7955 65
type: UnificationXref
id: 7955
db: ncbitaxon

Evidence 263
type: Evidence
evidence code: ISS
comment: SPACC P04049

Evidence 264
type: Evidence
evidence code: ISS
comment: SPACC P05625

Evidence 265
type: Evidence
evidence code: ISS
comment: SPACC P11345

Evidence 266
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QLB4 54
xref: PTHR24055:SF203
organism: Pan troglodytes

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot Q04982 286
organism: Gallus gallus

uniprot F7BD74 498
type: UnificationXref
id: F7BD74
db: uniprot

Mitogen-activated protein kinase-activated protein kinase 2a
type: ProteinReference
xref: uniprot Q7T2F2 414
organism: Danio rerio

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

AP1
type: Protein
entity reference: AP1
feature: AP1 s90 a114 rs1
feature: ACTIVE 45
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 656
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9DGE2 333
type: UnificationXref
id: Q9DGE2
db: uniprot

uniprot A0A3Q1LTT9 309
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

uniprot Q6EP31 366
type: UnificationXref
id: Q6EP31
db: uniprot

STATE_TRANSITION_LEFT__MEKK1_4-RIGHT__MEKK1_4-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 688
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 689
left: MEKK1/4
interaction type: STATE_TRANSITION
right: MEKK1/4

uniprot H2QCA7 422
type: UnificationXref
id: H2QCA7
db: uniprot

Phospholipase D alpha 1
type: ProteinReference
xref: uniprot Q43007 603
organism: Oryza sativa

uniprot Q5U1Y2 364
type: UnificationXref
id: Q5U1Y2
db: uniprot

ncbitaxon 6239 98
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot F7DUD6 463
type: UnificationXref
id: F7DUD6
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot F7BYN4 433
type: UnificationXref
id: F7BYN4
db: uniprot

uniprot P08644 148
type: UnificationXref
id: P08644
db: uniprot

uniprot F7EJU0 499
type: UnificationXref
id: F7EJU0
db: uniprot

KRAS isoform 4
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot A0A2I3T6U4 127
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r24 736
type: Stoichiometry
physical entity: MLK3
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q16539 328
xref: PTHR24055:SF110
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r34
controller: PDK

uniprot C3YJC1 340
type: UnificationXref
id: C3YJC1
db: uniprot

RGL1 isoform 1
type: ProteinReference
xref: uniprot K7B6P4 199
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r24 737
type: Stoichiometry
physical entity: MLK3
stoichiometric coefficient: 1.0

uniprot P47196 549
type: UnificationXref
id: P47196
db: uniprot

PLD
type: Protein
entity reference: PLD
feature: ACTIVE 45
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: uniprot Q5A1D3 61
xref: PTHR24055:SF158
organism: Candida albicans

uniprot F6Y4G8 569
type: UnificationXref
id: F6Y4G8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF199
xref: uniprot F6WB97 175
organism: Monodelphis domestica

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot E2R6T4 375
xref: PTHR11462:SF8
organism: Canis lupus familiaris

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF310
xref: uniprot C4M5T0 342
organism: Entamoeba histolytica

uniprot O42376 322
type: UnificationXref
id: O42376
db: uniprot

PI3K
type: ProteinReference
xref: P04567
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_ID_DESC=Ras Pathway.PROTEIN.GENERIC.PI3K
comment: ENTITY_REFERENCE_NOTES= Long Name: Phosphoinositide-3 kinase Synonym: PI3 kinase,PI3K Accession: P04567
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3
member entity reference: PIK3CG isoform 1
member entity reference: Phosphatidylinositol 3-kinase age-1
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 3-kinase 3
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: PI-3 kinase
member entity reference: Phosphatidylinositol 3-kinase 2
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: Phosphatidylinositol 3-kinase 1

uniprot F6ZM84 462
type: UnificationXref
id: F6ZM84
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r20
controller: PAK

Activating transcription factor 2
type: ProteinReference
xref: uniprot F1PCQ4 166
xref: PTHR19304:SF9
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R2N9 192
xref: PTHR23113:SF35
organism: Macaca mulatta

uniprot Q91Y86 585
type: UnificationXref
id: Q91Y86
db: uniprot

PLD
type: Protein
entity reference: PLD
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0G2K6E0 613
type: UnificationXref
id: A0A0G2K6E0
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XUP1 235
xref: PTHR48015:SF20
organism: Macaca mulatta

uniprot Q6NUX8 641
type: UnificationXref
id: Q6NUX8
db: uniprot

uniprot Q5F352 157
type: UnificationXref
id: Q5F352
db: uniprot

uniprot Q9WUT3 44
type: UnificationXref
id: Q9WUT3
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A7SFJ1 508
xref: PTHR24072:SF192
organism: Nematostella vectensis

Ras-related protein Rac2
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P48554 352
organism: Drosophila melanogaster

PIK3CG isoform 1
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot A0A2J8QY32 447
organism: Pan troglodytes

Ras-related protein Ral-a
type: ProteinReference
xref: uniprot P48555 181
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r35 707
type: Stoichiometry
physical entity: GSK3
stoichiometric coefficient: 1.0

uniprot H2R8L2 648
type: UnificationXref
id: H2R8L2
db: uniprot

uniprot F7BWW9 217
type: UnificationXref
id: F7BWW9
db: uniprot

ncbitaxon 10116 19
type: UnificationXref
id: 10116
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r35 706
type: Stoichiometry
physical entity: GSK3
stoichiometric coefficient: 1.0