STATE_TRANSITION_LEFT__SAX-RIGHT__SAX-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 195
left: SAX
interaction type: STATE_TRANSITION
right: SAX

PARTICIPANT STOICHIOMETRY re32 151
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

P06329
type: UnificationXref
id: P06329
db: PANTHER Pathway Component

HOMODIMER ID 49STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

P06331
type: UnificationXref
id: P06331
db: PANTHER Pathway Component

P06330
type: UnificationXref
id: P06330
db: PANTHER Pathway Component

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

STATE_TRANSITION_LEFT__SAX_SCW__PUT-_ATP-RIGHT__phosphoSAX__SCW__PUT-_ADP-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 177
left: SAX/SCW/ PUT
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: phosphoSAX/ SCW/ PUT

P06335
type: UnificationXref
id: P06335
db: PANTHER Pathway Component

uniprot Q9W3Q1 25
type: UnificationXref
id: Q9W3Q1
db: uniprot

P06333
type: UnificationXref
id: P06333
db: PANTHER Pathway Component

P06332
type: UnificationXref
id: P06332
db: PANTHER Pathway Component

HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

sa105_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

PARTICIPANT STOICHIOMETRY re12 194
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 1.0

Evidence 55
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0086361.html

PARTICIPANT STOICHIOMETRY re12 195
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re34
controller: LACK

uniprot A0A0B4K7J3 39
type: UnificationXref
id: A0A0B4K7J3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SAX_SCW__PUT-_ATP-RIGHT__phosphoSAX__SCW__PUT-_ADP-_re3
controller: PUT

Protein twisted gastrulation
type: ProteinReference
xref: uniprot P54356 47
xref: PTHR12312:SF16
organism: Drosophila melanogaster

PUT s55 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SCW
type: Protein
entity reference: SCW

SAX
type: Protein
entity reference: SAX
feature: SAX s72 sa54 rs1

PARTICIPANT STOICHIOMETRY re10 198
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

uniprot P26016 53
type: UnificationXref
id: P26016
db: uniprot

PARTICIPANT STOICHIOMETRY re10 197
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

MAD s74 sa56 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

PARTICIPANT STOICHIOMETRY re10 196
type: Stoichiometry
physical entity: SOG/TSG SCW dimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 150
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

NEJ
type: ProteinReference
xref: P06328
standard name: nejire
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.NEJ
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Nejire, isoform C

PARTICIPANT STOICHIOMETRY re10 199
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

SCW full length s22 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW full length
stoichiometric coefficient: 2.0

SCW s73 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

MAD
type: ProteinReference
xref: P06331
standard name: mothers against dpp
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.MAD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein mothers against dpp

PPM1A
type: ProteinReference
xref: P06332
standard name: protein phosphatase 2C alpha, beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.PPM1A
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Alphabet, isoform E

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 7

MAD s110 sa99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

MED s106 sa95 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PTHR13703:SF61
type: RelationshipXref
id: PTHR13703:SF61
db: PANTHER Family
relationship type: By Homology

PUT s71 sa53 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re14 191
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PUT
type: Protein
entity reference: PUT
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

SCW full length
type: ProteinReference
xref: P06322
standard name: screw
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.SCW_br_full length
member entity reference: Protein screw

PUT
type: Protein
entity reference: PUT

MAD s89 sa88 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

SCW/PUT_ phosphoSAX phosphoMAD
type: Complex
component stoichiometry: HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 35STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s74 sa56 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
component: PUT
component: SCW
component: SAX
component: MAD
feature: COMPLEX BINDING FEATURE s79 csa9 102
feature: COMPLEX BINDING FEATURE s79 csa9 106
feature: COMPLEX BINDING FEATURE s79 csa9 100
feature: COMPLEX BINDING FEATURE s79 csa9 104
cellular location: cytosol

proSCW
type: Complex
component stoichiometry: HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
component: ?
component: SCW
feature: COMPLEX BINDING FEATURE s37 csa4 84
feature: COMPLEX BINDING FEATURE s37 csa4 82
cellular location: Golgi apparatus

TRANSPORT_LEFT__proSCW-RIGHT__proSCW-_re5
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 167
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 166
left: proSCW
interaction type: TRANSPORT
right: proSCW

GO GO:0005829 5
type: UnificationXref
id: GO:0005829
db: GO

phosphoSAX/ SCW/ PUT
type: Complex
component stoichiometry: HOMODIMER ID 14STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 30STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
component: SCW
component: SAX
component: PUT
feature: COMPLEX BINDING FEATURE s20 csa3 124
feature: COMPLEX BINDING FEATURE s20 csa3 126
feature: COMPLEX BINDING FEATURE s20 csa3 122
cellular location: cytosol

PTHR47992:SF25
type: RelationshipXref
id: PTHR47992:SF25
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re13 192
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

uniprot P54356 47
type: UnificationXref
id: P54356
db: uniprot

PARTICIPANT STOICHIOMETRY re13 193
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

NEJ
type: Protein
entity reference: NEJ
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

SCW
type: Protein
entity reference: SCW

MAD s89 sa88 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re14 190
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 1.0

MAD s74 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re17 171
type: Stoichiometry
physical entity: SCW/PUT_ phosphoSAX MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 172
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re6 161
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

SOG s31 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 173
type: Stoichiometry
physical entity: SCW/PUT_ phosphoSAX phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 162
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

PUT
type: Protein
entity reference: PUT

PARTICIPANT STOICHIOMETRY re17 174
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re37 140
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

SCW full length
type: Protein
entity reference: SCW full length

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MAD-_MED-_re29
controller: PDP

SAX/SCW/ PUT
type: Complex
component stoichiometry: HOMODIMER ID 13STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 43STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 29STOICHIOMETRY ID COMPLEX
component: PUT
component: SCW
component: SAX
feature: COMPLEX BINDING FEATURE s6 csa2 130
feature: COMPLEX BINDING FEATURE s6 csa2 128
feature: COMPLEX BINDING FEATURE s6 csa2 132
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re6 160
type: Stoichiometry
physical entity: proSCW
stoichiometric coefficient: 1.0

MAD
type: Protein
entity reference: MAD
feature: MAD s113 sa101 rs2
feature: MAD s113 sa101 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s113 sa101 113
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAD s69 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

ncbitaxon 7227 7
type: UnificationXref
id: 7227
db: ncbitaxon

MAD
type: Protein
entity reference: MAD
feature: MAD s101 sa94 rs2
feature: MAD s101 sa94 rs1

DISSOCIATION_LEFT__SOG_TSG_SCW_dimer-RIGHT__SCW-_SOG-_TSG-_re10
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 198
left: SOG/TSG SCW dimer
interaction type: DISSOCIATION
right: SOG
right: TSG
right: SCW

SOG/TSG SCW dimer
type: Complex
component stoichiometry: SOG s31 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 32STOICHIOMETRY ID COMPLEX
component stoichiometry: TSG s32 sa26 STOICHIOMETRY ID COMPLEX
component: SOG
component: TSG
component: SCW
feature: COMPLEX BINDING FEATURE s30 csa6 98
feature: COMPLEX BINDING FEATURE s30 csa6 94
feature: COMPLEX BINDING FEATURE s30 csa6 96

MAD s113 sa101 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PANTHER Pathway P06216 1
type: UnificationXref
id: P06216
db: PANTHER Pathway

MAD s81 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

HOMODIMER ID 43STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

SAX
type: Protein
entity reference: SAX
feature: SAX s67 sa43 rs1

eco ECO:0000316 38
type: UnificationXref
id: ECO:0000316
db: eco

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 4

? s27 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

LACK s111 sa100 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

MAD s74 sa56 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MAD s80 sa66 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

PARTICIPANT STOICHIOMETRY re37 137
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re37 139
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re37 138
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s106 sa95 77
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PUT
type: Protein
entity reference: PUT

MAD s80 sa66 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Dorsal-ventral patterning protein Sog
type: ProteinReference
xref: PTHR46526:SF1
xref: uniprot Q24025 59
organism: Drosophila melanogaster

SOG
type: Protein
entity reference: SOG
comment: SPECIES_TYPE=PROTEIN

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 3

PTHR13832:SF571
type: RelationshipXref
id: PTHR13832:SF571
db: PANTHER Family
relationship type: By Homology

TRUNCATION
type: RelationshipTypeVocabulary

uniprot A0A0B4KG59 6
type: UnificationXref
id: A0A0B4KG59
db: uniprot

PARTICIPANT STOICHIOMETRY re16 180
type: Stoichiometry
physical entity: phosphoSAX/ SCW/ PUT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 181
type: Stoichiometry
physical entity: SCW/PUT_ phosphoSAX MAD
stoichiometric coefficient: 1.0

uniprot Q9V853 17
type: UnificationXref
id: Q9V853
db: uniprot

HOMODIMER ID 42STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

SAX
type: ProteinReference
xref: P06329
standard name: saxophone
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.RECEPTOR.SAX
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

SCW
type: Protein
entity reference: SCW

DISSOCIATION_LEFT__proSCW-RIGHT__?-_SCW-_re6
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 161
left: proSCW
interaction type: DISSOCIATION
right: ?
right: SCW

HOMODIMER ID 32STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

SCW/PUT_ phosphoSAX MAD
type: Complex
component stoichiometry: HOMODIMER ID 34STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s69 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
component: MAD
component: SCW
component: PUT
component: SAX
feature: COMPLEX BINDING FEATURE s59 csa7 90
feature: COMPLEX BINDING FEATURE s59 csa7 86
feature: COMPLEX BINDING FEATURE s59 csa7 92
feature: COMPLEX BINDING FEATURE s59 csa7 88
cellular location: cytosol

MAD s108 sa97 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

FUR1
type: Protein
entity reference: FUR1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

SAX s18 sa10 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

STATE_TRANSITION_LEFT__MAD-RIGHT__MAD-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 209
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 210
left: MAD
interaction type: STATE_TRANSITION
right: MAD

phosphoMAD LACK
type: Complex
component stoichiometry: MAD s113 sa101 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s114 sa102 STOICHIOMETRY ID COMPLEX
component: LACK
component: MAD
feature: COMPLEX BINDING FEATURE s112 csa17 114
feature: COMPLEX BINDING FEATURE s112 csa17 112
cellular location: cytosol

HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

SAX
type: Protein
entity reference: SAX
feature: SAX s1 sa1 rs1

uniprot P42003 24
type: UnificationXref
id: P42003
db: uniprot

TRANSPORT_LEFT__SAX-RIGHT__SAX-_re13
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 193
left: SAX
interaction type: TRANSPORT
right: SAX

SCW s10 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

uniprot Q24025 59
type: UnificationXref
id: Q24025
db: uniprot

PTHR46526:SF1
type: RelationshipXref
id: PTHR46526:SF1
db: PANTHER Family
relationship type: By Homology

00696
type: UnificationXref
id: MOD:00696
db: mod

STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 146
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 147
left: phosphoMAD LACK
interaction type: STATE_TRANSITION
right: phosphoMAD LACK

SHN
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 8

PARTICIPANT STOICHIOMETRY re30 154
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 155
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

HOMODIMER ID 51STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__MAD-RIGHT__MAD-_re33
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 149
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 148
left: MAD
interaction type: TRANSPORT
right: MAD

TRANSPORT_LEFT__MAD-RIGHT__MAD-_re32
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 151
left: MAD
interaction type: TRANSPORT
right: MAD

LACK
type: Protein
entity reference: LACK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__SAX-_SCW-RIGHT__SCW__SAX-_re1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 188
left: SAX
left: SCW
interaction type: HETERODIMER_ASSOCIATION
right: SCW/ SAX

MAD
type: Protein
entity reference: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s110 sa99 109
feature: MAD s110 sa99 rs2
feature: MAD s110 sa99 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P25723 36
type: UnificationXref
id: P25723
db: uniprot

PTHR23255:SF98
type: RelationshipXref
id: PTHR23255:SF98
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: RelationshipTypeVocabulary

MAD s93 sa91 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

SAX
type: Protein
entity reference: SAX
feature: SAX s53 sa39 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

MED
type: Protein
entity reference: MED
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAD s108 sa97 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

? s39 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PTHR45645:SF8
type: RelationshipXref
id: PTHR45645:SF8
db: PANTHER Family
relationship type: By Homology

Protein mothers against dpp
type: ProteinReference
xref: uniprot P42003 24
xref: PTHR13703:SF61
organism: Drosophila melanogaster

SCW
type: ProteinReference
xref: P06326
standard name: screw
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.TRUNCATED.SCW
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein screw

SAX s1 sa1 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PTHR11848:SF263
type: RelationshipXref
id: PTHR11848:SF263
db: PANTHER Family
relationship type: By Homology

MED
type: ProteinReference
xref: P06323
standard name: medea
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.MED
member entity reference: Mothers against decapentaplegic homolog
member entity reference: Protein mothers against dpp

PARTICIPANT STOICHIOMETRY re7 157
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 158
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 159
type: Stoichiometry
physical entity: SOG/TSG SCW dimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 156
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa72 73
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SCW s17 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

proSCW
type: Complex
component stoichiometry: HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 31STOICHIOMETRY ID COMPLEX
component: ?
component: SCW
feature: COMPLEX BINDING FEATURE s23 csa5 78
feature: COMPLEX BINDING FEATURE s23 csa5 80

SCW s68 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

FUR1
type: ProteinReference
xref: P06333
standard name: furin 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.FUR1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Furin-like protease 1, isoforms 1/1-X/2

PARTICIPANT STOICHIOMETRY re25 203
type: Stoichiometry
physical entity: NEJ
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 204
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 205
type: Stoichiometry
physical entity: NEJ/MED/ phosphoMAD
stoichiometric coefficient: 1.0

PUT s5 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

By Homology
type: RelationshipTypeVocabulary

SCW s14 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

GO GO:0005783 3
type: UnificationXref
id: GO:0005783
db: GO

PARTICIPANT STOICHIOMETRY re3 178
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 10.0

PARTICIPANT STOICHIOMETRY re3 177
type: Stoichiometry
physical entity: phosphoSAX/ SCW/ PUT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 176
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 10.0

PARTICIPANT STOICHIOMETRY re19 165
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 175
type: Stoichiometry
physical entity: SAX/SCW/ PUT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 163
type: Stoichiometry
physical entity: SCW/PUT_ phosphoSAX phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 164
type: Stoichiometry
physical entity: phosphoSAX/ SCW/ PUT
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__PUT-RIGHT__PUT-_re15
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 185
left: PUT
interaction type: TRANSPORT
right: PUT

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 23
xref: PTHR13703:SF45
xref: uniprot O62609 22
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re36 142
type: Stoichiometry
physical entity: sa105_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re36 141
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

MAD s69 sa46 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

SAX
type: Protein
entity reference: SAX
feature: SAX s18 sa10 rs1

SOG
type: ProteinReference
xref: P06335
standard name: short gastrulation
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.SOG
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dorsal-ventral patterning protein Sog

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SCW_PUT__phosphoSAX_MAD-_ATP-RIGHT__SCW_PUT__phosphoSAX_phosphoMAD-_ADP-_re17
controller: SAX

LACK s114 sa102 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

MAD s57 sa45 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MAD s101 sa94 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SCW
type: Protein
entity reference: SCW

Serine/threonine-protein kinase receptor
type: ProteinReference
evidence: Evidence 9
xref: PTHR23255:SF98
xref: uniprot A0A0B4KG59 6
organism: Drosophila melanogaster

P06323
type: UnificationXref
id: P06323
db: PANTHER Pathway Component

P06324
type: UnificationXref
id: P06324
db: PANTHER Pathway Component

MAD s69 sa46 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__SOG_TSG_SCW_dimer-RIGHT__SCW-_SOG-_TSG-_re10
controller: TLD

P06321
type: UnificationXref
id: P06321
db: PANTHER Pathway Component

P06322
type: UnificationXref
id: P06322
db: PANTHER Pathway Component

P06327
type: UnificationXref
id: P06327
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re33 148
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

P06328
type: UnificationXref
id: P06328
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re33 149
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

P06326
type: UnificationXref
id: P06326
db: PANTHER Pathway Component

MAD
type: Protein
entity reference: MAD
feature: MAD s83 sa71 rs1
feature: MAD s83 sa71 rs2

HOMODIMER ID 29STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

P06320
type: UnificationXref
id: P06320
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re29 202
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__SCW_full_length-RIGHT__proSCW-_SCW-_re4
controller: FUR1

SAX s18 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re29 201
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

MAD s57 sa45 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

PARTICIPANT STOICHIOMETRY re29 200
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

SAX s72 sa54 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAD s101 sa94 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

SAX s72 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re38 135
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re38 136
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re38 134
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

Dorsal-ventral patterning protein tolloid
type: ProteinReference
xref: uniprot P25723 36
xref: PTHR45645:SF8
organism: Drosophila melanogaster

SCW
type: Protein
entity reference: SCW

MAD s81 sa69 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

PTHR11254:SF395
type: RelationshipXref
id: PTHR11254:SF395
db: PANTHER Family
relationship type: By Homology

SAX s13 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

TRANSPORT
type: RelationshipTypeVocabulary

MAD s83 sa71 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MED
type: Protein
entity reference: MED
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

?
type: Complex
component stoichiometry: ? s25 sa24 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa24 81

?
type: Complex
component stoichiometry: ? s27 sa15 STOICHIOMETRY ID COMPLEX
component: ?

SCW/ SAX
type: Complex
component stoichiometry: HOMODIMER ID 42STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 28STOICHIOMETRY ID COMPLEX
component: SAX
component: SCW
feature: COMPLEX BINDING FEATURE s2 csa1 62
feature: COMPLEX BINDING FEATURE s2 csa1 60
cellular location: cytosol

?
type: Complex
component stoichiometry: ? s39 sa22 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa22 85
cellular location: Golgi apparatus

SAX s67 sa43 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

NEJ s91 sa90 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NEJ
stoichiometric coefficient: 1.0

MAD s83 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

Target genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

HETERODIMER_ASSOCIATION_LEFT__LACK-_MAD-RIGHT__phosphoMAD_LACK-_re38
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 134
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 136
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 135
left: LACK
left: MAD
interaction type: HETERODIMER_ASSOCIATION
right: phosphoMAD LACK

SHN
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s95 sa93 69
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 35STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

MAD
type: Complex
component stoichiometry: MAD s83 sa71 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s83 sa71 71
cellular location: cytosol

MAD
type: Complex
component stoichiometry: MAD s81 sa69 STOICHIOMETRY ID COMPLEX
component: MAD
cellular location: cytosol

SAX
type: Complex
component stoichiometry: SAX s72 sa54 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 sa54 103
cellular location: cytosol

?
type: Protein

MED s84 sa72 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

SAX
type: Complex
component stoichiometry: SAX s67 sa43 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa43 89
cellular location: cytosol

MAD
type: Protein
entity reference: MAD
feature: MAD s93 sa91 rs2
feature: MAD s93 sa91 rs1

SAX s67 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 sa89 119
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MED-_MAD-RIGHT__MED__phosphoMAD-_MAD-_re37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 138
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 139
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 137
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 140
left: MED
left: MAD
interaction type: STATE_TRANSITION
right: MAD
right: MED/ phosphoMAD

MAD
type: Complex
component stoichiometry: MAD s101 sa94 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s101 sa94 75
cellular location: nucleus

MAD
type: Protein
entity reference: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa46 93
feature: MAD s69 sa46 rs2
feature: MAD s69 sa46 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAD
type: Complex
component stoichiometry: MAD s89 sa88 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s89 sa88 117
cellular location: nucleus

SCW s4 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

MAD
type: Complex
component stoichiometry: MAD s93 sa91 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s93 sa91 65
cellular location: nucleus

HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re34 146
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re34 147
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

MAD s93 sa91 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

SCW
type: Complex
component stoichiometry: SCW s73 sa55 STOICHIOMETRY ID COMPLEX
component: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa55 105
cellular location: cytosol

MAD
type: Protein
entity reference: MAD
feature: MAD s89 sa88 rs2
feature: MAD s89 sa88 rs1

SCW
type: Complex
component stoichiometry: SCW s68 sa44 STOICHIOMETRY ID COMPLEX
component: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa44 91
cellular location: cytosol

GO GO:0005794 4
type: UnificationXref
id: GO:0005794
db: GO

MAD s81 sa69 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s94 sa92 67
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PTHR13808:SF1
type: RelationshipXref
id: PTHR13808:SF1
db: PANTHER Family
relationship type: By Homology

MAD
type: Protein
entity reference: MAD
feature: MAD s108 sa97 rs2
feature: MAD s108 sa97 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR12312:SF16
type: RelationshipXref
id: PTHR12312:SF16
db: PANTHER Family
relationship type: By Homology

HOMODIMER ID 28STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

SAX
type: Complex
component stoichiometry: SAX s52 sa38 STOICHIOMETRY ID COMPLEX
component: SAX
cellular location: endoplasmic reticulum

SAX
type: Complex
component stoichiometry: SAX s3 sa4 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa4 61
cellular location: cytosol

SAX
type: Complex
component stoichiometry: SAX s13 sa7 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa7 131
cellular location: cytosol

SAX
type: Complex
component stoichiometry: SAX s18 sa10 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa10 125
cellular location: cytosol

SAX s52 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

MAD s93 sa91 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SAX
type: Complex
component stoichiometry: SAX s1 sa1 STOICHIOMETRY ID COMPLEX
component: SAX
cellular location: cytosol

HOMODIMER ID 31STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

MED s94 sa92 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

SAX s52 sa38 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAD
type: Protein
entity reference: MAD
feature: MAD s81 sa69 rs2
feature: MAD s81 sa69 rs1

SCW
type: Complex
component stoichiometry: SCW s14 sa8 STOICHIOMETRY ID COMPLEX
component: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa8 133
cellular location: cytosol

uniprot P54631 19
type: UnificationXref
id: P54631
db: uniprot

SCW
type: Complex
component stoichiometry: SCW s10 sa3 STOICHIOMETRY ID COMPLEX
component: SCW

SCW
type: Complex
component stoichiometry: SCW s4 sa5 STOICHIOMETRY ID COMPLEX
component: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa5 63
cellular location: cytosol

TRUNCATION_LEFT__SCW_full_length-RIGHT__proSCW-_SCW-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 168
left: SCW full length
interaction type: TRUNCATION
right: SCW
right: proSCW

SCW
type: Complex
component stoichiometry: SCW s38 sa21 STOICHIOMETRY ID COMPLEX
component: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa21 83
cellular location: Golgi apparatus

SCW
type: Complex
component stoichiometry: SCW s33 sa27 STOICHIOMETRY ID COMPLEX
component: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa27 99

SCW
type: Complex
component stoichiometry: SCW s24 sa23 STOICHIOMETRY ID COMPLEX
component: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa23 79

SCW
type: Complex
component stoichiometry: SCW s17 sa11 STOICHIOMETRY ID COMPLEX
component: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa11 127
cellular location: cytosol

TSG s32 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

PTHR23255:SF72
type: RelationshipXref
id: PTHR23255:SF72
db: PANTHER Family
relationship type: By Homology

MAD s89 sa88 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

DISSOCIATION
type: InteractionVocabulary

SAX
type: Protein
entity reference: SAX
feature: SAX s52 sa38 rs1

PUT
type: Complex
component stoichiometry: PUT s55 sa41 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: endoplasmic reticulum

PUT
type: Complex
component stoichiometry: PUT s12 sa6 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa6 129
cellular location: cytosol

SCW
type: Protein
entity reference: SCW

PUT
type: Complex
component stoichiometry: PUT s16 sa9 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa9 123
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s66 sa42 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa42 87
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s71 sa53 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s71 sa53 101
cellular location: cytosol

PPM1A
type: Protein
entity reference: PPM1A
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION_LEFT__phosphoMAD_LACK-RIGHT__MAD-_LACK-_re35
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 145
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 144
left: phosphoMAD LACK
interaction type: DISSOCIATION
right: MAD
right: LACK

TRANSPORT_LEFT__MED__phosphoMAD-RIGHT__MED__phosphoMAD-_re30
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 155
left: MED/ phosphoMAD
interaction type: TRANSPORT
right: MED/ phosphoMAD

SCW s33 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

SCW full length
type: Complex
component stoichiometry: SCW full length s22 sa13 STOICHIOMETRY ID COMPLEX
component: SCW full length
cellular location: Golgi apparatus

HOMODIMER ID 50STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

SCW
type: Protein
entity reference: SCW

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MAD-_MED-_re29
controller: PPM1A

MAD
type: Protein
entity reference: MAD
feature: MAD s74 sa56 rs2
feature: MAD s74 sa56 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa56 107
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s114 sa102 115
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

?
type: Protein

TSG
type: Protein
entity reference: TSG
comment: SPECIES_TYPE=PROTEIN

PUT
type: Complex
component stoichiometry: PUT s5 sa2 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: cytosol

PUT
type: Protein
entity reference: PUT

PARTICIPANT STOICHIOMETRY re15 186
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re15 185
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SAX s13 sa7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAD
type: Protein
entity reference: MAD
feature: MAD s104 sa85 rs2
feature: MAD s104 sa85 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAD s113 sa101 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

SAX
type: Protein
entity reference: SAX
feature: SAX s3 sa4 rs1

Target transcripts
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

MED/ phosphoMAD
type: Complex
component stoichiometry: MED s84 sa72 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 49STOICHIOMETRY ID COMPLEX
component: MAD
component: MED
feature: COMPLEX BINDING FEATURE s82 csa12 72
feature: COMPLEX BINDING FEATURE s82 csa12 70
cellular location: cytosol

TLD
type: ProteinReference
xref: P06327
standard name: tolloid
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.TLD
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dorsal-ventral patterning protein tolloid

HETERODIMER_ASSOCIATION_LEFT__MAD-_phosphoSAX__SCW__PUT-RIGHT__SCW_PUT__phosphoSAX_MAD-_re16
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 181
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 180
left: phosphoSAX/ SCW/ PUT
left: MAD
interaction type: HETERODIMER_ASSOCIATION
right: SCW/PUT_ phosphoSAX MAD

MAD s83 sa71 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

HETERODIMER_ASSOCIATION_LEFT__PUT-_SCW__SAX-RIGHT__SAX_SCW__PUT-_re2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 184
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 182
left: SCW/ SAX
left: PUT
interaction type: HETERODIMER_ASSOCIATION
right: SAX/SCW/ PUT

PARTICIPANT STOICHIOMETRY re1 188
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re2 182
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

NEJ/MED/ phosphoMAD
type: Complex
component stoichiometry: HOMODIMER ID 50STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s90 sa89 STOICHIOMETRY ID COMPLEX
component stoichiometry: NEJ s91 sa90 STOICHIOMETRY ID COMPLEX
component: MAD
component: NEJ
component: MED
feature: COMPLEX BINDING FEATURE s88 csa13 120
feature: COMPLEX BINDING FEATURE s88 csa13 116
feature: COMPLEX BINDING FEATURE s88 csa13 118
cellular location: nucleus

PARTICIPANT STOICHIOMETRY re1 189
type: Stoichiometry
physical entity: SCW/ SAX
stoichiometric coefficient: 1.0

MAD s104 sa85 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re2 184
type: Stoichiometry
physical entity: SAX/SCW/ PUT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 183
type: Stoichiometry
physical entity: SCW/ SAX
stoichiometric coefficient: 1.0

SAX s3 sa4 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

IDA
type: EvidenceCodeVocabulary

TRANSPORT_LEFT__MED-RIGHT__MED-_re31
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 153
left: MED
interaction type: TRANSPORT
right: MED

HOMODIMER ID 30STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re31 153
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

SHN s95 sa93 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SHN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 152
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 187
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re22 209
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

SCW s24 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

TSG
type: ProteinReference
xref: P06330
standard name: twisted gastrulation
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.TSG
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein twisted gastrulation

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s111 sa100 111
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PUT
type: ProteinReference
xref: P06320
standard name: punt
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.RECEPTOR.PUT
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Serine/threonine-protein kinase receptor

STATE_TRANSITION_LEFT__MAD-RIGHT__sa105_degraded-_re36
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 141
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 142
left: MAD
interaction type: STATE_TRANSITION
right: sa105_degraded

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

MAD s113 sa101 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: uniprot P26016 53
xref: PTHR42884:SF3
organism: Drosophila melanogaster

NEJ
type: Protein
entity reference: NEJ
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa90 121
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot O62609 22
type: UnificationXref
id: O62609
db: uniprot

PARTICIPANT STOICHIOMETRY re16 179
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

TSG
type: Protein
entity reference: TSG
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa26 97
comment: SPECIES_TYPE=PROTEIN

PDP
type: Protein
entity reference: PDP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__NEJ-_MED__phosphoMAD-RIGHT__NEJ_MED__phosphoMAD-_re25
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 204
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 205
left: NEJ
left: MED/ phosphoMAD
interaction type: HETERODIMER_ASSOCIATION
right: NEJ/MED/ phosphoMAD

eco ECO:0000501 8
type: UnificationXref
id: ECO:0000501
db: eco

SCW s38 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

phosphoMAD LACK
type: Complex
component stoichiometry: MAD s110 sa99 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s111 sa100 STOICHIOMETRY ID COMPLEX
component: LACK
component: MAD
feature: COMPLEX BINDING FEATURE s109 csa16 110
feature: COMPLEX BINDING FEATURE s109 csa16 108
cellular location: cytosol

uniprot Q961C5 54
type: UnificationXref
id: Q961C5
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF72
xref: uniprot A0A0B4K7J3 39
organism: Drosophila melanogaster

SAX s3 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re35 143
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re35 144
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

LACK
type: ProteinReference
xref: P06321
standard name: lethal with a checkpoint kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.LACK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: E3 ubiquitin-protein ligase Smurf1

PARTICIPANT STOICHIOMETRY re4 170
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

PUT s16 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

HOMODIMER ID 13STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

uniprot M9MS40 37
type: UnificationXref
id: M9MS40
db: uniprot

SAX
type: Protein
entity reference: SAX
feature: SAX s13 sa7 rs1

PARTICIPANT STOICHIOMETRY re35 145
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 208
type: Stoichiometry
physical entity: SHN/MED/ phosphoMAD
stoichiometric coefficient: 1.0

TLD
type: Protein
entity reference: TLD
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 191
left: PUT
interaction type: STATE_TRANSITION
right: PUT

PUT
type: Protein
entity reference: PUT

HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re5 167
type: Stoichiometry
physical entity: proSCW
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 166
type: Stoichiometry
physical entity: proSCW
stoichiometric coefficient: 1.0

MAD s104 sa85 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

PUT
type: Protein
entity reference: PUT

MAD
type: Protein
entity reference: MAD
feature: MAD s80 sa66 rs1
feature: MAD s80 sa66 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re4 169
type: Stoichiometry
physical entity: proSCW
stoichiometric coefficient: 1.0

MED s90 sa89 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 168
type: Stoichiometry
physical entity: SCW full length
stoichiometric coefficient: 2.0

HOMODIMER ID 34STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

Evidence 9
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0003169.html

SCW
type: Protein
entity reference: SCW

PARTICIPANT STOICHIOMETRY re24 207
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 206
type: Stoichiometry
physical entity: SHN
stoichiometric coefficient: 1.0

PDP
type: ProteinReference
xref: P06324
standard name: pyruvate dehydrogenase phosphatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=SCW_signaling_pathway.PROTEIN.GENERIC.PDP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: GM14286p

MAD
type: Protein
entity reference: MAD
feature: MAD s57 sa45 rs2
feature: MAD s57 sa45 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__SCW_PUT__phosphoSAX_MAD-_ATP-RIGHT__SCW_PUT__phosphoSAX_phosphoMAD-_ADP-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 174
left: SCW/PUT_ phosphoSAX MAD
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: SCW/PUT_ phosphoSAX phosphoMAD

MAD s110 sa99 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.37

Nejire, isoform C
type: ProteinReference
xref: uniprot M9MS40 37
xref: PTHR13808:SF1
organism: Drosophila melanogaster

SCW_signaling_pathway
type: Pathway
pathway component: TRANSPORT_LEFT__PUT-RIGHT__PUT-_re15
pathway component: HETERODIMER_ASSOCIATION_LEFT__PUT-_SCW__SAX-RIGHT__SAX_SCW__PUT-_re2
pathway component: TRANSPORT_LEFT__MAD-RIGHT__MAD-_re33
pathway component: DISSOCIATION_LEFT__SOG_TSG_SCW_dimer-RIGHT__SCW-_SOG-_TSG-_re10
pathway component: DISSOCIATION_LEFT__phosphoMAD_LACK-RIGHT__MAD-_LACK-_re35
pathway component: HETERODIMER_ASSOCIATION_LEFT__LACK-_MAD-RIGHT__phosphoMAD_LACK-_re38
pathway component: TRANSPORT_LEFT__SAX-RIGHT__SAX-_re13
pathway component: STATE_TRANSITION_LEFT__SCW_PUT__phosphoSAX_MAD-_ATP-RIGHT__SCW_PUT__phosphoSAX_phosphoMAD-_ADP-_re17
pathway component: TRANSPORT_LEFT__MAD-RIGHT__MAD-_re32
pathway component: STATE_TRANSITION_LEFT__SAX-RIGHT__SAX-_re12
pathway component: STATE_TRANSITION_LEFT__MAD-RIGHT__MAD-_re22
pathway component: STATE_TRANSITION_LEFT__MAD-RIGHT__sa105_degraded-_re36
pathway component: HETERODIMER_ASSOCIATION_LEFT__SHN-_MED__phosphoMAD-RIGHT__SHN_MED__phosphoMAD-_re24
pathway component: HETERODIMER_ASSOCIATION_LEFT__SCW-_SOG-_TSG-RIGHT__SOG_TSG_SCW_dimer-_re7
pathway component: TRANSPORT_LEFT__proSCW-RIGHT__proSCW-_re5
pathway component: STATE_TRANSITION_LEFT__SAX_SCW__PUT-_ATP-RIGHT__phosphoSAX__SCW__PUT-_ADP-_re3
pathway component: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MAD-_MED-_re29
pathway component: DISSOCIATION_LEFT__SCW_PUT__phosphoSAX_phosphoMAD-RIGHT__phosphoSAX__SCW__PUT-_MAD-_re19
pathway component: TRUNCATION_LEFT__SCW_full_length-RIGHT__proSCW-_SCW-_re4
pathway component: STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re14
pathway component: TRANSPORT_LEFT__MED__phosphoMAD-RIGHT__MED__phosphoMAD-_re30
pathway component: HETERODIMER_ASSOCIATION_LEFT__NEJ-_MED__phosphoMAD-RIGHT__NEJ_MED__phosphoMAD-_re25
pathway component: HETERODIMER_ASSOCIATION_LEFT__SAX-_SCW-RIGHT__SCW__SAX-_re1
pathway component: DISSOCIATION_LEFT__proSCW-RIGHT__?-_SCW-_re6
pathway component: TRANSPORT_LEFT__MED-RIGHT__MED-_re31
pathway component: STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re34
pathway component: STATE_TRANSITION_LEFT__MED-_MAD-RIGHT__MED__phosphoMAD-_MAD-_re37
pathway component: HETERODIMER_ASSOCIATION_LEFT__MAD-_phosphoSAX__SCW__PUT-RIGHT__SCW_PUT__phosphoSAX_MAD-_re16
xref: PANTHER Pathway P06216 1
comment: MODEL_NOTES=

STATE_TRANSITION
type: InteractionVocabulary

GM14286p
type: ProteinReference
xref: PTHR13832:SF571
xref: uniprot Q9W3Q1 25
organism: Drosophila melanogaster

PUT s12 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

TRANSPORT
type: InteractionVocabulary

MAD s101 sa94 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__SCW-_SOG-_TSG-RIGHT__SOG_TSG_SCW_dimer-_re7
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 159
left: SOG
left: TSG
left: SCW
interaction type: HETERODIMER_ASSOCIATION
right: SOG/TSG SCW dimer

TRUNCATION
type: InteractionVocabulary

?
type: Protein

DISSOCIATION_LEFT__SCW_PUT__phosphoSAX_phosphoMAD-RIGHT__phosphoSAX__SCW__PUT-_MAD-_re19
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 163
left: SCW/PUT_ phosphoSAX phosphoMAD
interaction type: DISSOCIATION
right: phosphoSAX/ SCW/ PUT
right: MAD

HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 2.0

HOMODIMER ID 14STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SOG
type: Protein
entity reference: SOG
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa25 95
comment: SPECIES_TYPE=PROTEIN

MED/ phosphoMAD
type: Complex
component stoichiometry: MED s106 sa95 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 52STOICHIOMETRY ID COMPLEX
component: MAD
component: MED
feature: COMPLEX BINDING FEATURE s100 csa15 74
feature: COMPLEX BINDING FEATURE s100 csa15 76
cellular location: nucleus

Protein screw
type: ProteinReference
evidence: Evidence 20
xref: PTHR11848:SF263
xref: uniprot P54631 19
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re22 210
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

E3 ubiquitin-protein ligase Smurf1
type: ProteinReference
evidence: Evidence 18
xref: uniprot Q9V853 17
xref: PTHR11254:SF395
organism: Drosophila melanogaster

HOMODIMER ID 52STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 5

SHN/MED/ phosphoMAD
type: Complex
component stoichiometry: SHN s95 sa93 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 51STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s94 sa92 STOICHIOMETRY ID COMPLEX
component: MAD
component: SHN
component: MED
feature: COMPLEX BINDING FEATURE s92 csa14 64
feature: COMPLEX BINDING FEATURE s92 csa14 68
feature: COMPLEX BINDING FEATURE s92 csa14 66
cellular location: nucleus

SCW
type: Protein
entity reference: SCW

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 38

Evidence 18
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0029006.html

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MAD-_MED-_re29
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 200
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 202
left: MED/ phosphoMAD
interaction type: DISSOCIATION
right: MED
right: MAD

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

SAX s53 sa39 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

HETERODIMER_ASSOCIATION_LEFT__SHN-_MED__phosphoMAD-RIGHT__SHN_MED__phosphoMAD-_re24
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 208
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 206
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 207
left: SHN
left: MED/ phosphoMAD
interaction type: HETERODIMER_ASSOCIATION
right: SHN/MED/ phosphoMAD

SAX s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

MAD s110 sa99 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PUT s66 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

? s25 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

Evidence 23
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0011655.html

Alphabet, isoform E
type: ProteinReference
evidence: Evidence 55
xref: PTHR47992:SF25
xref: uniprot Q961C5 54
organism: Drosophila melanogaster

Evidence 20
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0005590.html