Thymidine phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot Q9AK36 80
organism: Streptomyces coelicolor

Putative cytidine deaminase
type: ProteinReference
xref: uniprot Q9AK37 59
organism: Streptomyces coelicolor

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot P73717 35
organism: Synechocystis

tRNA(Ile)-lysidine synthase
type: ProteinReference
xref: uniprot Q9RV23 65
organism: Deinococcus radiodurans

uniprot Q89DE3 49
type: UnificationXref
id: Q89DE3
db: uniprot

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 62

ncbitaxon 7227 47
type: UnificationXref
id: 7227
db: ncbitaxon

Thymidine kinase, cytosolic
type: ProteinReference
xref: uniprot P04184 90
organism: Mus musculus

Thymidine kinase, cytosolic
type: ProteinReference
xref: uniprot P04183 89
organism: Homo sapiens

uniprot Q27564 93
type: UnificationXref
id: Q27564
db: uniprot

uniprot Q9HPQ9 98
type: UnificationXref
id: Q9HPQ9
db: uniprot

uniprot Q20628 40
type: UnificationXref
id: Q20628
db: uniprot

Thymidine kinase, cytosolic
type: ProteinReference
xref: uniprot P04047 87
organism: Gallus gallus

uniprot Q09190 39
type: UnificationXref
id: Q09190
db: uniprot

ncbitaxon 559292 30
type: UnificationXref
id: 559292
db: ncbitaxon

Thymidine kinase
type: ProteinReference
xref: P03147
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Thymidine kinase Synonym: Synonym not specified Accession: P03147
comment: ENTITY_REFERENCE_ID_DESC=Salvage pyrimidine deoxyribonucleotides.PROTEIN.GENERIC.Thymidine kinase
member entity reference: Thymidine kinase
member entity reference: Thymidine kinase, cytosolic
member entity reference: Thymidine kinase a
member entity reference: Thymidine kinase b
member entity reference: Thymidine kinase 1

uracil
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 100226 58
type: UnificationXref
id: 100226
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__thymidine-_ATP-RIGHT__ADP-_dTMP-_r5
controller: Thymidine kinase

uniprot P9WPH3 37
type: UnificationXref
id: P9WPH3
db: uniprot

uniprot O34598 15
type: UnificationXref
id: O34598
db: uniprot

Putative cytidine deaminase
type: ProteinReference
xref: uniprot Q09190 39
organism: Schizosaccharomyces pombe

ncbitaxon 10116 7
type: UnificationXref
id: 10116
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9XXD0 73
organism: Caenorhabditis elegans

deoxyribose-1-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 22

Thymidine kinase
type: ProteinReference
xref: uniprot A8WXG7 83
organism: Caenorhabditis briggsae

uniprot H2PY87 10
type: UnificationXref
id: H2PY87
db: uniprot

ncbitaxon 224308 16
type: UnificationXref
id: 224308
db: ncbitaxon

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 72

uniprot Q9AK36 80
type: UnificationXref
id: Q9AK36
db: uniprot

PARTICIPANT STOICHIOMETRY r5 114
type: Stoichiometry
physical entity: thymidine
stoichiometric coefficient: 1.0

Mus musculus
type: BioSource
xref: ncbitaxon 10090 32

eco ECO:0000250 12
type: UnificationXref
id: ECO:0000250
db: eco

PARTICIPANT STOICHIOMETRY r4 118
type: Stoichiometry
physical entity: deoxyribose-1-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 119
type: Stoichiometry
physical entity: thymine
stoichiometric coefficient: 1.0

uniprot H2QTU8 14
type: UnificationXref
id: H2QTU8
db: uniprot

Cytidine deaminase
type: ProteinReference
xref: uniprot Q9WZV0 71
organism: Thermotoga maritima

PARTICIPANT STOICHIOMETRY r5 116
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 115
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot H2QDZ3 86
type: UnificationXref
id: H2QDZ3
db: uniprot

PARTICIPANT STOICHIOMETRY r5 117
type: Stoichiometry
physical entity: dTMP
stoichiometric coefficient: 1.0

ncbitaxon 64091 62
type: UnificationXref
id: 64091
db: ncbitaxon

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 30

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 36

Uncharacterized protein
type: ProteinReference
xref: uniprot Q95Y87 56
organism: Caenorhabditis elegans

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 47

ADAT2 isoform 2
type: ProteinReference
xref: uniprot H2QTU8 14
organism: Pan troglodytes

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 12

Pyrimidine-nucleoside phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot Q9RX72 81
organism: Deinococcus radiodurans

Cytidine/deoxycytidylate deaminase family protein
type: ProteinReference
xref: uniprot Q8TKJ8 51
organism: Methanosarcina acetivorans

uniprot Q9S750 100
type: UnificationXref
id: Q9S750
db: uniprot

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot P68398 33
organism: Escherichia coli

Cytidine deaminase
type: ProteinReference
xref: uniprot Q9VLR3 70
organism: Drosophila melanogaster

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot O69719 19
organism: Mycobacterium tuberculosis

uniprot Q9S7I0 66
type: UnificationXref
id: Q9S7I0
db: uniprot

PARTICIPANT STOICHIOMETRY r4 121
type: Stoichiometry
physical entity: thymidine
stoichiometric coefficient: 1.0

uniprot P68398 33
type: UnificationXref
id: P68398
db: uniprot

Cytidine deaminase
type: ProteinReference
xref: uniprot Q9VLR2 69
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r4 120
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

uniprot G5EEZ5 85
type: UnificationXref
id: G5EEZ5
db: uniprot

Cytidine deaminase
type: ProteinReference
xref: uniprot Q8ZYG2 53
organism: Pyrobaculum aerophilum

NH3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein CBG09150
type: ProteinReference
xref: uniprot A8X869 2
organism: Caenorhabditis briggsae

Cytidine deaminase
type: ProteinReference
xref: uniprot P19079 25
organism: Bacillus subtilis

PANTHER Pathway P02774 1
type: UnificationXref
id: P02774
db: PANTHER Pathway

Thymidine kinase
type: ProteinReference
xref: uniprot Q9HPQ9 98
organism: Halobacterium salinarum

uniprot P21335 26
type: UnificationXref
id: P21335
db: uniprot

Uncharacterized protein (Fragment) (Fragment)
type: ProteinReference
xref: uniprot B7PXR7 4
organism: Ixodes scapularis

Cytidine deaminase
type: ProteinReference
xref: uniprot H2PY87 10
xref: PTHR11644:SF2
organism: Pan troglodytes

Pyrimidine-nucleoside phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot P39142 75
organism: Bacillus subtilis

dTMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cytidine aminohydrolase
type: ProteinReference
xref: uniprot Q9HR24 61
organism: Halobacterium salinarum

uniprot Q95QD6 55
type: UnificationXref
id: Q95QD6
db: uniprot

STATE_TRANSITION_LEFT__H2O-_deoxycytidine-RIGHT__deoxyuridine-_NH3-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 113
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 111
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 112
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 110
left: deoxycytidine
left: H2O
interaction type: STATE_TRANSITION
right: deoxyuridine
right: NH3

ncbitaxon 9544 9
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot Q9AK37 59
type: UnificationXref
id: Q9AK37
db: uniprot

Thymidine phosphorylase
type: Protein
entity reference: Thymidine phosphorylase
comment: SPECIES_TYPE=PROTEIN

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 24

tRNA(adenine(34)) deaminase, chloroplastic
type: ProteinReference
xref: uniprot Q9S7I0 66
organism: Arabidopsis thaliana

ncbitaxon 44689 94
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot Q4QC75 95
type: UnificationXref
id: Q4QC75
db: uniprot

Thymidine kinase 1
type: ProteinReference
xref: uniprot Q27564 93
organism: Dictyostelium discoideum

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot Q9AK79 60
organism: Streptomyces coelicolor

Cytidine deaminase
type: ProteinReference
xref: uniprot D4AC20 6
organism: Rattus norvegicus

uniprot O69719 19
type: UnificationXref
id: O69719
db: uniprot

Thymidine phosphorylase
type: ProteinReference
xref: P03148
comment: ENTITY_REFERENCE_ID_DESC=Salvage pyrimidine deoxyribonucleotides.PROTEIN.GENERIC.Thymidine phosphorylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Thymidine phosphorylase Synonym: Synonym not specified Accession: P03148
member entity reference: Thymidine phosphorylase
member entity reference: AMP phosphorylase
member entity reference: Pyrimidine-nucleoside phosphorylase

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 11

Thymidine kinase
type: ProteinReference
xref: uniprot H2QDZ3 86
organism: Pan troglodytes

uniprot F7GAS0 8
type: UnificationXref
id: F7GAS0
db: uniprot

ncbitaxon 188937 52
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot P39142 75
type: UnificationXref
id: P39142
db: uniprot

Uracil phosphorylase
type: ProteinReference
xref: P03145
comment: ENTITY_REFERENCE_ID_DESC=Salvage pyrimidine deoxyribonucleotides.PROTEIN.GENERIC.Uracil phosphorylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Uracil phosphorylase Synonym: Synonym not specified Accession: P03145
member entity reference: Thymidine phosphorylase
member entity reference: AMP phosphorylase
member entity reference: Pyrimidine-nucleoside phosphorylase

ncbitaxon 243232 78
type: UnificationXref
id: 243232
db: ncbitaxon

Guanine deaminase
type: ProteinReference
xref: uniprot O34598 15
organism: Bacillus subtilis

uniprot Q9RSE7 63
type: UnificationXref
id: Q9RSE7
db: uniprot

ncbitaxon 178306 54
type: UnificationXref
id: 178306
db: ncbitaxon

Thymidine kinase b
type: ProteinReference
xref: uniprot F4KBF5 84
organism: Arabidopsis thaliana

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 64

ncbitaxon 284812 24
type: UnificationXref
id: 284812
db: ncbitaxon

By Homology
type: RelationshipTypeVocabulary

ncbitaxon 243274 72
type: UnificationXref
id: 243274
db: ncbitaxon

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 28

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 78

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

thymidine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 5664 96
type: UnificationXref
id: 5664
db: ncbitaxon

ncbitaxon 224911 50
type: UnificationXref
id: 224911
db: ncbitaxon

STATE_TRANSITION_LEFT__PO4-_deoxyuridine-RIGHT__uracil-_deoxyribose_1_phosphate-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 103
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 104
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 105
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 102
left: PO4
left: deoxyuridine
interaction type: STATE_TRANSITION
right: deoxyribose-1-phosphate
right: uracil

Pyrimidine-nucleoside phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot Q9S5X9 82
organism: Thermotoga maritima

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__deoxyribose_1_phosphate-_thymine-RIGHT__PO4-_thymidine-_r4
controller: Thymidine phosphorylase

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 67

Cytidine deaminase
type: ProteinReference
xref: uniprot Q20628 40
organism: Caenorhabditis elegans

RE41712p
type: ProteinReference
xref: uniprot Q9VEM0 68
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r3 102
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 103
type: Stoichiometry
physical entity: deoxyuridine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 104
type: Stoichiometry
physical entity: uracil
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 105
type: Stoichiometry
physical entity: deoxyribose-1-phosphate
stoichiometric coefficient: 1.0

tRNA-specific adenosine deaminase subunit TAD2
type: ProteinReference
xref: uniprot P47058 29
organism: Saccharomyces cerevisiae

Cytidine deaminase
type: ProteinReference
xref: uniprot Q06549 38
organism: Saccharomyces cerevisiae

Thymidine kinase
type: ProteinReference
xref: uniprot G5EEZ5 85
organism: Caenorhabditis elegans

ncbitaxon 272561 22
type: UnificationXref
id: 272561
db: ncbitaxon

Thymidine kinase
type: ProteinReference
xref: uniprot Q9RSY5 99
organism: Deinococcus radiodurans

Cytidine deaminase
type: Protein
entity reference: Cytidine deaminase
comment: SPECIES_TYPE=PROTEIN

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 20

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PO4-_deoxyuridine-RIGHT__uracil-_deoxyribose_1_phosphate-_r3
controller: Uracil phosphorylase

ncbitaxon 6945 5
type: UnificationXref
id: 6945
db: ncbitaxon

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 34

uniprot P23331 91
type: UnificationXref
id: P23331
db: uniprot

uniprot O94642 23
type: UnificationXref
id: O94642
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__deoxyuridine-_ATP-RIGHT__dUMP-_ADP-_r2
controller: Deoxyuridine kinase

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GAS0 8
organism: Macaca mulatta

tRNA-specific adenosine deaminase subunit tad2
type: ProteinReference
xref: uniprot O94642 23
organism: Schizosaccharomyces pombe

uniprot Q7Z6V5 48
type: UnificationXref
id: Q7Z6V5
db: uniprot

uniprot P19079 25
type: UnificationXref
id: P19079
db: uniprot

uniprot Q9RSY5 99
type: UnificationXref
id: Q9RSY5
db: uniprot

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot P21335 26
organism: Bacillus subtilis

ncbitaxon 243230 64
type: UnificationXref
id: 243230
db: ncbitaxon

tRNA-specific adenosine deaminase 2
type: ProteinReference
xref: uniprot Q5E9J7 43
organism: Bos taurus

ncbitaxon 83333 34
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot Q8ZV53 97
type: UnificationXref
id: Q8ZV53
db: uniprot

Salvage pyrimidine deoxyribonucleotides
type: Pathway
pathway component: STATE_TRANSITION_LEFT__deoxyuridine-_ATP-RIGHT__dUMP-_ADP-_r2
pathway component: STATE_TRANSITION_LEFT__thymidine-_ATP-RIGHT__ADP-_dTMP-_r5
pathway component: STATE_TRANSITION_LEFT__deoxyribose_1_phosphate-_thymine-RIGHT__PO4-_thymidine-_r4
pathway component: STATE_TRANSITION_LEFT__H2O-_deoxycytidine-RIGHT__deoxyuridine-_NH3-_r1
pathway component: STATE_TRANSITION_LEFT__PO4-_deoxyuridine-RIGHT__uracil-_deoxyribose_1_phosphate-_r3
xref: PANTHER Pathway P02774 1
comment: MODEL_NOTES= Pyrimidine deoxyribonucleotides can be synthesize in two ways: de novo biosynthesis and salvaging pathways. In salvaging pathways nucleosides and bases from RNA and DNA breakdown can reenter de novo pyrimidine deoxyribonucleotide biosynthesis. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

P03145
type: UnificationXref
id: P03145
db: PANTHER Pathway Component

P03144
type: UnificationXref
id: P03144
db: PANTHER Pathway Component

P03148
type: UnificationXref
id: P03148
db: PANTHER Pathway Component

P03147
type: UnificationXref
id: P03147
db: PANTHER Pathway Component

P03146
type: UnificationXref
id: P03146
db: PANTHER Pathway Component

Uracil phosphorylase
type: Protein
entity reference: Uracil phosphorylase
comment: SPECIES_TYPE=PROTEIN

Deoxyuridine kinase
type: ProteinReference
xref: P03146
comment: ENTITY_REFERENCE_ID_DESC=Salvage pyrimidine deoxyribonucleotides.PROTEIN.GENERIC.Deoxyuridine kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Deoxyuridine kinase Synonym: Synonym not specified Accession: P03146
member entity reference: Thymidine kinase
member entity reference: Thymidine kinase, cytosolic
member entity reference: Thymidine kinase a
member entity reference: Thymidine kinase b
member entity reference: Thymidine kinase 1

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 16

PARTICIPANT STOICHIOMETRY r2 106
type: Stoichiometry
physical entity: deoxyuridine
stoichiometric coefficient: 1.0

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 94

Bos taurus
type: BioSource
xref: ncbitaxon 9913 44

uniprot Q9WYN2 101
type: UnificationXref
id: Q9WYN2
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 9

PARTICIPANT STOICHIOMETRY r2 107
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 108
type: Stoichiometry
physical entity: dUMP
stoichiometric coefficient: 1.0

uniprot P56389 31
type: UnificationXref
id: P56389
db: uniprot

PARTICIPANT STOICHIOMETRY r2 109
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q9VLR3 70
type: UnificationXref
id: Q9VLR3
db: uniprot

Cytidine deaminase
type: ProteinReference
xref: uniprot P56389 31
organism: Mus musculus

ncbitaxon 224324 18
type: UnificationXref
id: 224324
db: ncbitaxon

tRNA-specific adenosine deaminase 2
type: ProteinReference
xref: uniprot Q7Z6V5 48
organism: Homo sapiens

tRNA-specific adenosine deaminase 2
type: ProteinReference
xref: uniprot Q6P6J0 45
organism: Mus musculus

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot Q89DE3 49
organism: Bradyrhizobium diazoefficiens

Cytidine deaminase
type: ProteinReference
xref: uniprot P9WPH3 37
organism: Mycobacterium tuberculosis

uniprot Q22922 42
type: UnificationXref
id: Q22922
db: uniprot

Cytidine deaminase
type: ProteinReference
xref: P03144
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Cytidine deaminase Synonym: Synonym not specified Accession: P03144
comment: ENTITY_REFERENCE_ID_DESC=Salvage pyrimidine deoxyribonucleotides.PROTEIN.GENERIC.Cytidine deaminase
member entity reference: Uncharacterized protein
member entity reference: Guanine deaminase
member entity reference: Cytidine/deoxycytidylate deaminase family protein
member entity reference: tRNA-specific adenosine deaminase
member entity reference: tRNA-specific adenosine deaminase 2
member entity reference: Cytidine deaminase
member entity reference: Putative cytidine deaminase
member entity reference: Uncharacterized protein (Fragment) (Fragment)
member entity reference: Protein CBG09150
member entity reference: Putative deaminase
member entity reference: tRNA-specific adenosine deaminase subunit TAD2
member entity reference: tRNA(Ile)-lysidine synthase
member entity reference: ADAT2 isoform 2
member entity reference: tRNA(adenine(34)) deaminase, chloroplastic
member entity reference: tRNA-specific adenosine deaminase subunit tad2
member entity reference: Cytidine aminohydrolase
member entity reference: RE41712p

dUMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P32320 27
type: UnificationXref
id: P32320
db: uniprot

PTHR11644:SF11
type: RelationshipXref
id: PTHR11644:SF11
db: PANTHER Family
relationship type: By Homology

uniprot B7PXR7 4
type: UnificationXref
id: B7PXR7
db: uniprot

uniprot Q9AK79 60
type: UnificationXref
id: Q9AK79
db: uniprot

uniprot F4KBF5 84
type: UnificationXref
id: F4KBF5
db: uniprot

ncbitaxon 9606 28
type: UnificationXref
id: 9606
db: ncbitaxon

thymine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: uniprot Q7KTJ2 46
organism: Drosophila melanogaster

uniprot P9WFS1 76
type: UnificationXref
id: P9WFS1
db: uniprot

uniprot Q9S5X9 82
type: UnificationXref
id: Q9S5X9
db: uniprot

STATE_TRANSITION_LEFT__deoxyuridine-_ATP-RIGHT__dUMP-_ADP-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 109
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 106
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 107
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 108
left: ATP
left: deoxyuridine
interaction type: STATE_TRANSITION
right: ADP
right: dUMP

AMP phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot Q58081 77
organism: Methanocaldococcus jannaschii

ncbitaxon 10090 32
type: UnificationXref
id: 10090
db: ncbitaxon

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 52

uniprot Q9VLR2 69
type: UnificationXref
id: Q9VLR2
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 5

STATE_TRANSITION_LEFT__deoxyribose_1_phosphate-_thymine-RIGHT__PO4-_thymidine-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 120
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 119
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 118
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 121
left: deoxyribose-1-phosphate
left: thymine
interaction type: STATE_TRANSITION
right: thymidine
right: PO4

ncbitaxon 6238 3
type: UnificationXref
id: 6238
db: ncbitaxon

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 7

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 18

ncbitaxon 3702 67
type: UnificationXref
id: 3702
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r1 110
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot A8X869 2
type: UnificationXref
id: A8X869
db: uniprot

Putative deaminase
type: ProteinReference
xref: uniprot Q9ADJ9 57
organism: Streptomyces coelicolor

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 88

PARTICIPANT STOICHIOMETRY r1 111
type: Stoichiometry
physical entity: deoxycytidine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 112
type: Stoichiometry
physical entity: deoxyuridine
stoichiometric coefficient: 1.0

deoxycytidine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Bradyrhizobium diazoefficiens
type: BioSource
xref: ncbitaxon 224911 50

uniprot Q9WZV0 71
type: UnificationXref
id: Q9WZV0
db: uniprot

PARTICIPANT STOICHIOMETRY r1 113
type: Stoichiometry
physical entity: NH3
stoichiometric coefficient: 1.0

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 54

uniprot Q9RV23 65
type: UnificationXref
id: Q9RV23
db: uniprot

uniprot Q03221 92
type: UnificationXref
id: Q03221
db: uniprot

uniprot O67050 17
type: UnificationXref
id: O67050
db: uniprot

uniprot Q9XXD0 73
type: UnificationXref
id: Q9XXD0
db: uniprot

uniprot O84851 21
type: UnificationXref
id: O84851
db: uniprot

Thymidine kinase
type: ProteinReference
xref: uniprot Q8ZV53 97
organism: Pyrobaculum aerophilum

PTHR10515:SF0
type: RelationshipXref
id: PTHR10515:SF0
db: PANTHER Family
relationship type: By Homology

uniprot Q7KTJ2 46
type: UnificationXref
id: Q7KTJ2
db: uniprot

uniprot P47058 29
type: UnificationXref
id: P47058
db: uniprot

ncbitaxon 9913 44
type: UnificationXref
id: 9913
db: ncbitaxon

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 58

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cytidine deaminase
type: ProteinReference
xref: uniprot P32320 27
xref: PTHR11644:SF2
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot Q95QD6 55
organism: Caenorhabditis elegans

Thymidine phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot P07650 74
organism: Escherichia coli

ncbitaxon 9598 11
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot Q8TL01 79
type: UnificationXref
id: Q8TL01
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

uniprot P73717 35
type: UnificationXref
id: P73717
db: uniprot

PTHR11644:SF2
type: RelationshipXref
id: PTHR11644:SF2
db: PANTHER Family
relationship type: By Homology

Deoxyuridine kinase
type: Protein
entity reference: Deoxyuridine kinase
comment: SPECIES_TYPE=PROTEIN

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot O67050 17
organism: Aquifex aeolicus

uniprot Q9HR24 61
type: UnificationXref
id: Q9HR24
db: uniprot

Thymidine kinase
type: ProteinReference
xref: uniprot Q03221 92
organism: Bacillus subtilis

uniprot Q6P6J0 45
type: UnificationXref
id: Q6P6J0
db: uniprot

uniprot Q95Y87 56
type: UnificationXref
id: Q95Y87
db: uniprot

deoxyuridine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P04183 89
type: UnificationXref
id: P04183
db: uniprot

ncbitaxon 9031 88
type: UnificationXref
id: 9031
db: ncbitaxon

Cytidine deaminase
type: ProteinReference
xref: uniprot Q9RSE7 63
organism: Deinococcus radiodurans

uniprot Q5E9J7 43
type: UnificationXref
id: Q5E9J7
db: uniprot

Thymidine kinase a
type: ProteinReference
xref: uniprot Q9S750 100
organism: Arabidopsis thaliana

uniprot A8WXG7 83
type: UnificationXref
id: A8WXG7
db: uniprot

Thymidine kinase
type: Protein
entity reference: Thymidine kinase
comment: SPECIES_TYPE=PROTEIN

Cytidine deaminase
type: ProteinReference
xref: PTHR11644:SF11
xref: uniprot Q22922 42
organism: Caenorhabditis elegans

uniprot Q9ADJ9 57
type: UnificationXref
id: Q9ADJ9
db: uniprot

uniprot P07650 74
type: UnificationXref
id: P07650
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_deoxycytidine-RIGHT__deoxyuridine-_NH3-_r1
controller: Cytidine deaminase

Leishmania major
type: BioSource
xref: ncbitaxon 5664 96

Thymidine kinase
type: ProteinReference
xref: uniprot Q4QC75 95
organism: Leishmania major

Thymidine kinase
type: ProteinReference
xref: uniprot P23331 91
organism: Escherichia coli

uniprot Q8TKJ8 51
type: UnificationXref
id: Q8TKJ8
db: uniprot

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P04047 87
type: UnificationXref
id: P04047
db: uniprot

ncbitaxon 6239 41
type: UnificationXref
id: 6239
db: ncbitaxon

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 3

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 41

ncbitaxon 83332 20
type: UnificationXref
id: 83332
db: ncbitaxon

uniprot Q9VEM0 68
type: UnificationXref
id: Q9VEM0
db: uniprot

uniprot D4AC20 6
type: UnificationXref
id: D4AC20
db: uniprot

uniprot Q06549 38
type: UnificationXref
id: Q06549
db: uniprot

ncbitaxon 1111708 36
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot Q8ZYG2 53
type: UnificationXref
id: Q8ZYG2
db: uniprot

uniprot Q58081 77
type: UnificationXref
id: Q58081
db: uniprot

uniprot P04184 90
type: UnificationXref
id: P04184
db: uniprot

Thymidine kinase
type: ProteinReference
xref: uniprot Q9WYN2 101
organism: Thermotoga maritima

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__thymidine-_ATP-RIGHT__ADP-_dTMP-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 116
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 117
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 115
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 114
left: thymidine
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: dTMP

Thymidine phosphorylase
type: ProteinReference
xref: uniprot P9WFS1 76
organism: Mycobacterium tuberculosis

AMP phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot Q8TL01 79
organism: Methanosarcina acetivorans

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot O84851 21
organism: Chlamydia trachomatis

uniprot Q9RX72 81
type: UnificationXref
id: Q9RX72
db: uniprot