2-oxoglutarate dehydrogenase, mitochondrial
type: ProteinReference
xref: PTHR23152:SF7
xref: uniprot Q60597 70
organism: Mus musculus

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: uniprot P20004 52
organism: Bos taurus

ncbitaxon 7955 36
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot O74882 95
type: UnificationXref
id: O74882
db: uniprot

uniprot A0A2I3TIU1 2
type: UnificationXref
id: A0A2I3TIU1
db: uniprot

eco ECO:0000250 10
type: UnificationXref
id: ECO:0000250
db: eco

Fumarate hydratase, mitochondrial
type: ProteinReference
xref: PTHR11444:SF1
xref: uniprot P08417 87
organism: Saccharomyces cerevisiae

PTHR11739:SF4
type: RelationshipXref
id: PTHR11739:SF4
db: PANTHER Family
relationship type: By Homology

uniprot F0ZX52 24
type: UnificationXref
id: F0ZX52
db: uniprot

Succinyl CoA Synthetase
type: Protein
entity reference: Succinyl CoA Synthetase
comment: SPECIES_TYPE=PROTEIN

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: uniprot H2QI84 104
xref: PTHR11117:SF2
organism: Pan troglodytes

uniprot F6VWV9 84
type: UnificationXref
id: F6VWV9
db: uniprot

PTHR11516:SF60
type: RelationshipXref
id: PTHR11516:SF60
db: PANTHER Family
relationship type: By Homology

Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: uniprot Q65ZG5 112
xref: PTHR11117:SF2
organism: Trichomonas vaginalis

Citrate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q7ZVY5 35
xref: PTHR11739:SF8
organism: Danio rerio

Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: uniprot O15568 105
xref: PTHR11117:SF2
organism: Trichomonas vaginalis

Fumarate hydratase
type: ProteinReference
xref: uniprot E2RGR9 82
xref: PTHR11444:SF1
organism: Canis lupus familiaris

uniprot P57106 74
type: UnificationXref
id: P57106
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Fumarate-_H2O-RIGHT__Malate-_r19
controller: Fumarase

uniprot P07954 86
type: UnificationXref
id: P07954
db: uniprot

GDP + Pi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aconitase
type: ProteinReference
xref: P01268
comment: ENTITY_REFERENCE_NOTES= Long Name: Aconitase Synonym: Synonym not specified Accession: P01268
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TCA cycle.PROTEIN.GENERIC.Aconitase
member entity reference: Aconitate hydratase, mitochondrial
member entity reference: Uncharacterized protein
member entity reference: Aconitate hydratase, putative
member entity reference: Uncharacterized protein YbhJ
member entity reference: Aconitase 2
member entity reference: Aconitase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Citrate-RIGHT__cis_Aconitate-_H2O-_r13
controller: Aconitase

ncbitaxon 9598 3
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot A0A1D5QB91 44
type: UnificationXref
id: A0A1D5QB91
db: uniprot

uniprot Q28DK1 33
type: UnificationXref
id: Q28DK1
db: uniprot

Fumarate hydratase
type: ProteinReference
xref: PTHR11444:SF1
xref: uniprot H2Q1E9 85
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Succinyl_CoA-_GDP__PLUS__Pi-RIGHT__Succinate-_GTP-_r17
controller: Succinyl CoA Synthetase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD_PLUS_-_Malate-RIGHT__NADH_PLUS_H_PLUS_-_Oxaloacetate-_r20
controller: Malate Dehydrogenase

GTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 9

Malate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Mus musculus
type: BioSource
xref: ncbitaxon 10090 16

Fumarate hydratase, mitochondrial
type: ProteinReference
xref: PTHR11444:SF1
xref: uniprot P07954 86
organism: Homo sapiens

PTHR11739:SF8
type: RelationshipXref
id: PTHR11739:SF8
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD_PLUS_-_IsoCitrate-RIGHT__Oxalosuccinate-_NADH_PLUS_H_PLUS_-_r6
controller: Isocitrate Dehydrogenase

Fumarate hydratase, mitochondrial
type: ProteinReference
xref: PTHR11444:SF1
xref: uniprot P14408 88
organism: Rattus norvegicus

ncbitaxon 44689 38
type: UnificationXref
id: 44689
db: ncbitaxon

PANTHER Pathway P00051 1
type: UnificationXref
id: P00051
db: PANTHER Pathway

Uncharacterized protein YbhJ
type: ProteinReference
xref: uniprot P75764 53
organism: Escherichia coli

ncbitaxon 39947 79
type: UnificationXref
id: 39947
db: ncbitaxon

STATE_TRANSITION_LEFT__NAD_PLUS_-_coA-_alphaKetoglutarate-RIGHT__CO2-_Succinyl_CoA-_NADH_PLUS_H_PLUS_-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 146
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 142
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 144
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 145
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 141
left: NAD+
left: alphaKetoglutarate
left: coA
interaction type: STATE_TRANSITION
right: CO2
right: NADH+H+
right: Succinyl-CoA

Citrate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

OGDH isoform 6
type: ProteinReference
xref: PTHR23152:SF7
xref: uniprot H2QUI7 63
organism: Pan troglodytes

uniprot Q99KI0 58
type: UnificationXref
id: Q99KI0
db: uniprot

Acetyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 28

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD_PLUS_-_coA-_alphaKetoglutarate-RIGHT__CO2-_Succinyl_CoA-_NADH_PLUS_H_PLUS_-_r16
controller: alphaketoglutarate Dehydrogenase

Succinate Dehydrogenase
type: Protein
entity reference: Succinate Dehydrogenase
comment: SPECIES_TYPE=PROTEIN

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 92

Succinyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 42

STATE_TRANSITION_LEFT__cis_Aconitate-_H2O-RIGHT__IsoCitrate-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 115
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 116
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 114
left: H2O
left: cis-Aconitate
interaction type: STATE_TRANSITION
right: IsoCitrate

2-oxoglutarate dehydrogenase, mitochondrial
type: ProteinReference
xref: PTHR23152:SF7
xref: uniprot Q148N0 68
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Succinate-_FAD-RIGHT__FADH2-_Fumarate-_r18
controller: Succinate Dehydrogenase

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 10

uniprot F6Q200 4
type: UnificationXref
id: F6Q200
db: uniprot

uniprot Q60597 70
type: UnificationXref
id: Q60597
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Acetyl_CoA-_H2O-_Oxaloacetate-RIGHT__Citrate-_coA-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 121
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 123
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 122
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 125
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 124
left: H2O
left: Acetyl-CoA
left: Oxaloacetate
interaction type: HETERODIMER_ASSOCIATION
right: Citrate
right: coA

Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: uniprot A2DUL5 100
xref: PTHR11117:SF2
organism: Trichomonas vaginalis

Citrate synthase, peroxisomal
type: ProteinReference
xref: PTHR11739:SF8
xref: uniprot P08679 27
organism: Saccharomyces cerevisiae

ncbitaxon 224324 50
type: UnificationXref
id: 224324
db: ncbitaxon

uniprot P75764 53
type: UnificationXref
id: P75764
db: uniprot

PTHR11444:SF1
type: RelationshipXref
id: PTHR11444:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q8T4D6 56
type: UnificationXref
id: Q8T4D6
db: uniprot

P01268
type: UnificationXref
id: P01268
db: PANTHER Pathway Component

P01267
type: UnificationXref
id: P01267
db: PANTHER Pathway Component

P01266
type: UnificationXref
id: P01266
db: PANTHER Pathway Component

uniprot P53597 109
type: UnificationXref
id: P53597
db: uniprot

uniprot Q8MQU6 37
type: UnificationXref
id: Q8MQU6
db: uniprot

Malate dehydrogenase, cytoplasmic
type: ProteinReference
xref: uniprot P40925 73
organism: Homo sapiens

P01269
type: UnificationXref
id: P01269
db: PANTHER Pathway Component

Pyruvate Dehydrogenase
type: ProteinReference
xref: P01266
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TCA cycle.PROTEIN.GENERIC.Pyruvate_br_Dehydrogenase
comment: ENTITY_REFERENCE_NOTES= Long Name: Pyruvate Dehydrogenase Synonym: Synonym not specified Accession: P01266
member entity reference: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
member entity reference: Pyruvate dehydrogenase kinase 2
member entity reference: Pyruvate dehydrogenase E1 component subunit alpha
member entity reference: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
member entity reference: Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
member entity reference: Uncharacterized protein
member entity reference: Putative pyruvate dehydrogenase alpha subunit

Pyruvate dehydrogenase kinase 2
type: ProteinReference
xref: uniprot A0A2I3TIU1 2
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r5 114
type: Stoichiometry
physical entity: cis-Aconitate
stoichiometric coefficient: 1.0

Citrate synthase
type: ProteinReference
xref: uniprot Q95TZ4 41
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r5 116
type: Stoichiometry
physical entity: IsoCitrate
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 7

PARTICIPANT STOICHIOMETRY r5 115
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot E2R0Y5 102
type: UnificationXref
id: E2R0Y5
db: uniprot

uniprot P35486 15
type: UnificationXref
id: P35486
db: uniprot

STATE_TRANSITION_LEFT__Succinyl_CoA-_GDP__PLUS__Pi-RIGHT__Succinate-_GTP-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 140
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 139
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 138
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 137
left: GDP + Pi
left: Succinyl-CoA
interaction type: STATE_TRANSITION
right: GTP
right: Succinate

P01271
type: UnificationXref
id: P01271
db: PANTHER Pathway Component

P01270
type: UnificationXref
id: P01270
db: PANTHER Pathway Component

eco ECO:0000501 67
type: UnificationXref
id: ECO:0000501
db: eco

CO2+ NADH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR10978:SF5
type: RelationshipXref
id: PTHR10978:SF5
db: PANTHER Family
relationship type: By Homology

PTHR10978:SF3
type: RelationshipXref
id: PTHR10978:SF3
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9615 83
type: UnificationXref
id: 9615
db: ncbitaxon

P01273
type: UnificationXref
id: P01273
db: PANTHER Pathway Component

uniprot F7DSQ0 61
type: UnificationXref
id: F7DSQ0
db: uniprot

ncbitaxon 208964 111
type: UnificationXref
id: 208964
db: ncbitaxon

P01274
type: UnificationXref
id: P01274
db: PANTHER Pathway Component

IsoCitrate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: uniprot C8VG90 46
xref: PTHR43160:SF3
organism: Emericella nidulans

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 96

uniprot Q148N0 68
type: UnificationXref
id: Q148N0
db: uniprot

uniprot Q148D3 90
type: UnificationXref
id: Q148D3
db: uniprot

Aconitase
type: Protein
entity reference: Aconitase
comment: SPECIES_TYPE=PROTEIN

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: ProteinReference
xref: uniprot P08559 12
organism: Homo sapiens

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
type: ProteinReference
xref: uniprot Q64536 19
organism: Rattus norvegicus

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: uniprot A0A1D5QHY3 99
xref: PTHR11117:SF2
organism: Macaca mulatta

uniprot Q64536 19
type: UnificationXref
id: Q64536
db: uniprot

TCA cycle
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Acetyl_CoA-_H2O-_Oxaloacetate-RIGHT__Citrate-_coA-_r23
pathway component: STATE_TRANSITION_LEFT__Succinate-_FAD-RIGHT__FADH2-_Fumarate-_r18
pathway component: STATE_TRANSITION_LEFT__coA__PLUS__NAD_PLUS_-_Pyruvate-RIGHT__Acetyl_CoA-_CO2_PLUS__NADH-_r24
pathway component: STATE_TRANSITION_LEFT__Citrate-RIGHT__cis_Aconitate-_H2O-_r13
pathway component: STATE_TRANSITION_LEFT__Succinyl_CoA-_GDP__PLUS__Pi-RIGHT__Succinate-_GTP-_r17
pathway component: STATE_TRANSITION_LEFT__NAD_PLUS_-_IsoCitrate-RIGHT__Oxalosuccinate-_NADH_PLUS_H_PLUS_-_r6
pathway component: STATE_TRANSITION_LEFT__Oxalosuccinate-RIGHT__CO2-_alphaKetoglutarate-_r15
pathway component: STATE_TRANSITION_LEFT__NAD_PLUS_-_coA-_alphaKetoglutarate-RIGHT__CO2-_Succinyl_CoA-_NADH_PLUS_H_PLUS_-_r16
pathway component: STATE_TRANSITION_LEFT__NAD_PLUS_-_Malate-RIGHT__NADH_PLUS_H_PLUS_-_Oxaloacetate-_r20
pathway component: STATE_TRANSITION_LEFT__Fumarate-_H2O-RIGHT__Malate-_r19
pathway component: STATE_TRANSITION_LEFT__cis_Aconitate-_H2O-RIGHT__IsoCitrate-_r5
xref: PANTHER Pathway P00051 1
comment: MODEL_NOTES= Kreb's Cycle: Also known as Tricarboxylic Acid Cycle. Eight enzymes of the catalytic series of well-know organic reactions that collectively oxidize an acetyl group to two CO2 molceules with the concomitant generation of three NADHs, one FADH2, and one GTP.

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 3

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: PTHR11117:SF2
xref: uniprot P13086 108
organism: Rattus norvegicus

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 34

uniprot Q5XI78 69
type: UnificationXref
id: Q5XI78
db: uniprot

Fumarase
type: Protein
entity reference: Fumarase
comment: SPECIES_TYPE=PROTEIN

Citrate Synthase
type: ProteinReference
xref: P01267
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Citrate Synthase Synonym: Synonym not specified Accession: P01267
comment: ENTITY_REFERENCE_ID_DESC=TCA cycle.PROTEIN.GENERIC.Citrate_br_Synthase
member entity reference: Citrate synthase, mitochondrial
member entity reference: Probable citrate synthase, mitochondrial
member entity reference: Citrate synthase
member entity reference: Citrate synthase, peroxisomal

uniprot G7MLD3 62
type: UnificationXref
id: G7MLD3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__cis_Aconitate-_H2O-RIGHT__IsoCitrate-_r5
controller: Aconitase

uniprot Q7ZVY5 35
type: UnificationXref
id: Q7ZVY5
db: uniprot

PARTICIPANT STOICHIOMETRY r24 117
type: Stoichiometry
physical entity: coA + NAD+
stoichiometric coefficient: 1.0

uniprot F1MZ38 103
type: UnificationXref
id: F1MZ38
db: uniprot

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: ProteinReference
xref: PTHR10978:SF5
xref: uniprot P35720 97
organism: Bos taurus

Citrate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q9CZU6 43
organism: Mus musculus

uniprot O15568 105
type: UnificationXref
id: O15568
db: uniprot

PARTICIPANT STOICHIOMETRY r24 118
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 119
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

ncbitaxon 284812 96
type: UnificationXref
id: 284812
db: ncbitaxon

Citrate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q28DK1 33
xref: PTHR11739:SF8
organism: Xenopus tropicalis

STATE_TRANSITION_LEFT__coA__PLUS__NAD_PLUS_-_Pyruvate-RIGHT__Acetyl_CoA-_CO2_PLUS__NADH-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 119
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 117
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 118
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 120
left: coA + NAD+
left: Pyruvate
interaction type: STATE_TRANSITION
right: CO2+ NADH
right: Acetyl-CoA

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: PTHR11117:SF2
xref: uniprot F1MZ38 103
organism: Bos taurus

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 81

Geobacter sulfurreducens
type: BioSource
xref: ncbitaxon 243231 55

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: uniprot P19414 51
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r24 120
type: Stoichiometry
physical entity: CO2+ NADH
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QB91 44
organism: Macaca mulatta

uniprot P35720 97
type: UnificationXref
id: P35720
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 13

uniprot Q9VIE8 60
type: UnificationXref
id: Q9VIE8
db: uniprot

NAD+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 77

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: uniprot Q99798 57
organism: Homo sapiens

uniprot Q74AD1 54
type: UnificationXref
id: Q74AD1
db: uniprot

PTHR23152:SF7
type: RelationshipXref
id: PTHR23152:SF7
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__NAD_PLUS_-_IsoCitrate-RIGHT__Oxalosuccinate-_NADH_PLUS_H_PLUS_-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 156
left: NAD+
left: IsoCitrate
interaction type: STATE_TRANSITION
right: Oxalosuccinate
right: NADH+H+

PTHR23152:SF4
type: RelationshipXref
id: PTHR23152:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q7UM46 71
type: UnificationXref
id: Q7UM46
db: uniprot

uniprot H2Q1E9 85
type: UnificationXref
id: H2Q1E9
db: uniprot

STATE_TRANSITION_LEFT__NAD_PLUS_-_Malate-RIGHT__NADH_PLUS_H_PLUS_-_Oxaloacetate-_r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 130
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 132
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 129
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 131
left: Malate
left: NAD+
interaction type: STATE_TRANSITION
right: Oxaloacetate
right: NADH+H+

uniprot E2R9X3 94
type: UnificationXref
id: E2R9X3
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 75

PARTICIPANT STOICHIOMETRY r19 127
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Alpha-ketoglutarate dehydrogenase E1
type: ProteinReference
xref: PTHR23152:SF4
xref: uniprot Q7UM46 71
organism: Rhodopirellula baltica

PARTICIPANT STOICHIOMETRY r19 128
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

uniprot Q51567 110
type: UnificationXref
id: Q51567
db: uniprot

PARTICIPANT STOICHIOMETRY r19 126
type: Stoichiometry
physical entity: Fumarate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 145
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 144
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 146
type: Stoichiometry
physical entity: NADH+H+
stoichiometric coefficient: 1.0

ncbitaxon 9913 5
type: UnificationXref
id: 9913
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r16 141
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

ncbitaxon 5786 25
type: UnificationXref
id: 5786
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r16 143
type: Stoichiometry
physical entity: alphaKetoglutarate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 142
type: Stoichiometry
physical entity: coA
stoichiometric coefficient: 1.0

uniprot P0AGE9 107
type: UnificationXref
id: P0AGE9
db: uniprot

FAD
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O75390 26
type: UnificationXref
id: O75390
db: uniprot

alphaketoglutarate Dehydrogenase
type: Protein
entity reference: alphaketoglutarate Dehydrogenase
comment: SPECIES_TYPE=PROTEIN

Trichomonas vaginalis
type: BioSource
xref: ncbitaxon 5722 101

Citrate synthase
type: ProteinReference
xref: PTHR42871:SF1
xref: uniprot P0ABH7 29
organism: Escherichia coli

Succinate dehydrogenase complex subunit C
type: ProteinReference
xref: PTHR10978:SF5
xref: uniprot E2R9X3 94
organism: Canis lupus familiaris

Danio rerio
type: BioSource
xref: ncbitaxon 7955 36

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 30

ncbitaxon 100226 23
type: UnificationXref
id: 100226
db: ncbitaxon

ncbitaxon 10116 20
type: UnificationXref
id: 10116
db: ncbitaxon

ncbitaxon 83333 30
type: UnificationXref
id: 83333
db: ncbitaxon

alphaketoglutarate Dehydrogenase
type: ProteinReference
xref: P01269
comment: ENTITY_REFERENCE_ID_DESC=TCA cycle.PROTEIN.GENERIC._alpha_ketoglutarate_br_Dehydrogenase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: alphaketoglutarate Dehydrogenase Synonym: Synonym not specified Accession: P01269
member entity reference: 2-oxoglutarate dehydrogenase, mitochondrial
member entity reference: Alpha-ketoglutarate dehydrogenase E1
member entity reference: 2-oxoglutarate dehydrogenase E1 component
member entity reference: Uncharacterized protein
member entity reference: Oxoglutarate dehydrogenase
member entity reference: OGDH isoform 6

uniprot O84829 106
type: UnificationXref
id: O84829
db: uniprot

uniprot A0A1D5QHY3 99
type: UnificationXref
id: A0A1D5QHY3
db: uniprot

uniprot Q8F4A2 80
type: UnificationXref
id: Q8F4A2
db: uniprot

uniprot P0ABH7 29
type: UnificationXref
id: P0ABH7
db: uniprot

Pyruvate Dehydrogenase
type: Protein
entity reference: Pyruvate Dehydrogenase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 272561 9
type: UnificationXref
id: 272561
db: ncbitaxon

uniprot P97807 89
type: UnificationXref
id: P97807
db: uniprot

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: ProteinReference
xref: uniprot P35486 15
organism: Mus musculus

Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
type: ProteinReference
xref: uniprot P35487 17
organism: Mus musculus

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: PTHR11117:SF2
xref: uniprot P53597 109
organism: Homo sapiens

uniprot Q02218 66
type: UnificationXref
id: Q02218
db: uniprot

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR42871:SF1
type: RelationshipXref
id: PTHR42871:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q55674 91
type: UnificationXref
id: Q55674
db: uniprot

ncbitaxon 1111708 92
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot E2RGR9 82
type: UnificationXref
id: E2RGR9
db: uniprot

uniprot Q99643 98
type: UnificationXref
id: Q99643
db: uniprot

PTHR11516:SF2
type: RelationshipXref
id: PTHR11516:SF2
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r17 137
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r17 138
type: Stoichiometry
physical entity: GDP + Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r17 139
type: Stoichiometry
physical entity: Succinate
stoichiometric coefficient: 1.0

uniprot Q58820 76
type: UnificationXref
id: Q58820
db: uniprot

2-oxoglutarate dehydrogenase, mitochondrial
type: ProteinReference
xref: PTHR23152:SF7
xref: uniprot Q02218 66
organism: Homo sapiens

Isocitrate Dehydrogenase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: ProteinReference
xref: PTHR10978:SF3
xref: uniprot Q99643 98
organism: Homo sapiens

Putative pyruvate dehydrogenase alpha subunit
type: ProteinReference
xref: uniprot Q9K3H0 22
xref: PTHR11516:SF2
organism: Streptomyces coelicolor

Uncharacterized protein
type: ProteinReference
xref: PTHR10978:SF3
xref: uniprot A0A1D5QTZ3 93
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Oxalosuccinate-RIGHT__CO2-_alphaKetoglutarate-_r15
controller: Isocitrate Dehydrogenase

Succinyl CoA Synthetase
type: ProteinReference
xref: P01274
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Succinyl CoA Synthetase Synonym: Synonym not specified Accession: P01274
comment: ENTITY_REFERENCE_ID_DESC=TCA cycle.PROTEIN.GENERIC.Succinyl CoA_br_Synthetase
member entity reference: Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
member entity reference: Succinate--CoA ligase [ADP-forming] subunit alpha
member entity reference: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

L-sulfolactate dehydrogenase
type: ProteinReference
xref: PTHR11091:SF0
xref: uniprot Q58820 76
organism: Methanocaldococcus jannaschii

uniprot Q9CZU6 43
type: UnificationXref
id: Q9CZU6
db: uniprot

Oxoglutarate dehydrogenase
type: ProteinReference
xref: uniprot F7DSQ0 61
xref: PTHR23152:SF7
organism: Monodelphis domestica

ncbitaxon 6239 32
type: UnificationXref
id: 6239
db: ncbitaxon

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 65

Citrate synthase
type: ProteinReference
xref: uniprot F0ZX52 24
xref: PTHR11739:SF4
organism: Dictyostelium purpureum

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 38

ncbitaxon 227321 47
type: UnificationXref
id: 227321
db: ncbitaxon

Bos taurus
type: BioSource
xref: ncbitaxon 9913 5

PARTICIPANT STOICHIOMETRY r20 129
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

PTHR11117:SF2
type: RelationshipXref
id: PTHR11117:SF2
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Oxalosuccinate-RIGHT__CO2-_alphaKetoglutarate-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 147
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 149
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 148
left: Oxalosuccinate
interaction type: STATE_TRANSITION
right: CO2
right: alphaKetoglutarate

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 45

IDA
type: EvidenceCodeVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR23152:SF7
xref: uniprot G7MLD3 62
organism: Macaca mulatta

ncbitaxon 5722 101
type: UnificationXref
id: 5722
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r20 132
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Acetyl_CoA-_H2O-_Oxaloacetate-RIGHT__Citrate-_coA-_r23
controller: Citrate Synthase

uniprot P08417 87
type: UnificationXref
id: P08417
db: uniprot

Aconitate hydratase, putative
type: ProteinReference
xref: uniprot Q74AD1 54
organism: Geobacter sulfurreducens

uniprot Q8VHF5 40
type: UnificationXref
id: Q8VHF5
db: uniprot

Succinate dehydrogenase cytochrome B subunit, mitochondrial
type: ProteinReference
xref: PTHR10978:SF5
xref: uniprot O74882 95
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r20 130
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

Fumarase
type: ProteinReference
xref: P01271
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Fumarase Synonym: Synonym not specified Accession: P01271
comment: ENTITY_REFERENCE_ID_DESC=TCA cycle.PROTEIN.GENERIC.Fumarase
member entity reference: Uncharacterized protein
member entity reference: Fumarate hydratase class II
member entity reference: Fumarate hydratase
member entity reference: Fumarate hydratase, mitochondrial

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 67

PARTICIPANT STOICHIOMETRY r20 131
type: Stoichiometry
physical entity: NADH+H+
stoichiometric coefficient: 1.0

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: uniprot Q8T4D6 56
organism: Drosophila melanogaster

uniprot Q95TZ4 41
type: UnificationXref
id: Q95TZ4
db: uniprot

STATE_TRANSITION_LEFT__Fumarate-_H2O-RIGHT__Malate-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 127
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 128
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 126
left: H2O
left: Fumarate
interaction type: STATE_TRANSITION
right: Malate

uniprot O67656 49
type: UnificationXref
id: O67656
db: uniprot

ncbitaxon 13616 7
type: UnificationXref
id: 13616
db: ncbitaxon

Fumarate hydratase
type: ProteinReference
xref: PTHR11444:SF1
xref: uniprot Q148D3 90
organism: Bos taurus

ncbitaxon 189518 81
type: UnificationXref
id: 189518
db: ncbitaxon

uniprot P19414 51
type: UnificationXref
id: P19414
db: uniprot

uniprot P08679 27
type: UnificationXref
id: P08679
db: uniprot

Malate dehydrogenase, cytoplasmic
type: ProteinReference
xref: uniprot Q7XDC8 78
xref: PTHR23382:SF3
organism: Oryza sativa

uniprot O84247 8
type: UnificationXref
id: O84247
db: uniprot

Aconitase 2
type: ProteinReference
xref: uniprot H2QLS4 48
organism: Pan troglodytes

Malate Dehydrogenase
type: ProteinReference
xref: P01270
comment: ENTITY_REFERENCE_ID_DESC=TCA cycle.PROTEIN.GENERIC.Malate_br_Dehydrogenase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Malate Dehydrogenase Synonym: Synonym not specified Accession: P01270
member entity reference: Malate dehydrogenase, cytoplasmic
member entity reference: Malate dehydrogenase 2, cytoplasmic
member entity reference: L-sulfolactate dehydrogenase
member entity reference: Malate dehydrogenase

PTHR43160:SF3
type: RelationshipXref
id: PTHR43160:SF3
db: PANTHER Family
relationship type: By Homology

Succinate--CoA ligase [ADP-forming] subunit alpha
type: ProteinReference
xref: uniprot O84829 106
xref: PTHR11117:SF2
organism: Chlamydia trachomatis

PARTICIPANT STOICHIOMETRY r23 121
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

PTHR23382:SF3
type: RelationshipXref
id: PTHR23382:SF3
db: PANTHER Family
relationship type: By Homology

uniprot H2QI84 104
type: UnificationXref
id: H2QI84
db: uniprot

PTHR23382:SF0
type: RelationshipXref
id: PTHR23382:SF0
db: PANTHER Family
relationship type: By Homology

Citrate synthase, mitochondrial
type: ProteinReference
xref: uniprot O75390 26
organism: Homo sapiens

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
type: ProteinReference
xref: uniprot Q15119 18
organism: Homo sapiens

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 20

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 50

Pyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P40925 73
type: UnificationXref
id: P40925
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 83

uniprot P14408 88
type: UnificationXref
id: P14408
db: uniprot

ncbitaxon 8364 34
type: UnificationXref
id: 8364
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r23 125
type: Stoichiometry
physical entity: coA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 124
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 123
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

uniprot Q15119 18
type: UnificationXref
id: Q15119
db: uniprot

uniprot P20004 52
type: UnificationXref
id: P20004
db: uniprot

PARTICIPANT STOICHIOMETRY r23 122
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Oxalosuccinate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 224308 65
type: UnificationXref
id: 224308
db: ncbitaxon

FADH2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AM02 6
organism: Monodelphis domestica

Citrate synthase, peroxisomal
type: ProteinReference
xref: uniprot Q8MQU6 37
xref: PTHR11739:SF4
organism: Dictyostelium discoideum

coA + NAD+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Fumarate hydratase class II
type: ProteinReference
xref: PTHR11444:SF1
xref: uniprot Q55674 91
organism: Synechocystis

uniprot P08559 12
type: UnificationXref
id: P08559
db: uniprot

2-oxoglutarate dehydrogenase, mitochondrial
type: ProteinReference
xref: PTHR23152:SF7
xref: uniprot Q5XI78 69
organism: Rattus norvegicus

ncbitaxon 243232 77
type: UnificationXref
id: 243232
db: ncbitaxon

uniprot P23129 64
type: UnificationXref
id: P23129
db: uniprot

uniprot Q65ZG5 112
type: UnificationXref
id: Q65ZG5
db: uniprot

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
type: ProteinReference
xref: uniprot Q9JK42 21
organism: Mus musculus

uniprot Q9K3H0 22
type: UnificationXref
id: Q9K3H0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Q200 4
organism: Bos taurus

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 72

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 23

Uncharacterized protein
type: ProteinReference
xref: PTHR11444:SF1
xref: uniprot F6VWV9 84
organism: Macaca mulatta

uniprot P13086 108
type: UnificationXref
id: P13086
db: uniprot

PARTICIPANT STOICHIOMETRY r13 152
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Fumarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2QUI7 63
type: UnificationXref
id: H2QUI7
db: uniprot

PARTICIPANT STOICHIOMETRY r13 151
type: Stoichiometry
physical entity: cis-Aconitate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 133
type: Stoichiometry
physical entity: Succinate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 150
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 134
type: Stoichiometry
physical entity: FAD
stoichiometric coefficient: 1.0

Succinate--CoA ligase [ADP-forming] subunit alpha
type: ProteinReference
xref: uniprot P0AGE9 107
xref: PTHR11117:SF2
organism: Escherichia coli

By Homology
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r15 148
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 147
type: Stoichiometry
physical entity: Oxalosuccinate
stoichiometric coefficient: 1.0

uniprot Q9JK42 21
type: UnificationXref
id: Q9JK42
db: uniprot

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: uniprot Q9ER34 59
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r15 149
type: Stoichiometry
physical entity: alphaKetoglutarate
stoichiometric coefficient: 1.0

Aconitase
type: ProteinReference
xref: uniprot O67656 49
xref: PTHR43160:SF3
organism: Aquifex aeolicus

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY r18 135
type: Stoichiometry
physical entity: FADH2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 136
type: Stoichiometry
physical entity: Fumarate
stoichiometric coefficient: 1.0

Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
type: ProteinReference
xref: uniprot P29803 14
organism: Homo sapiens

ncbitaxon 9544 45
type: UnificationXref
id: 9544
db: ncbitaxon

Pyruvate dehydrogenase E1 component subunit alpha
type: ProteinReference
xref: uniprot O84247 8
xref: PTHR11516:SF60
organism: Chlamydia trachomatis

uniprot C8VG90 46
type: UnificationXref
id: C8VG90
db: uniprot

uniprot H2QLS4 48
type: UnificationXref
id: H2QLS4
db: uniprot

uniprot Q99798 57
type: UnificationXref
id: Q99798
db: uniprot

PTHR11091:SF0
type: RelationshipXref
id: PTHR11091:SF0
db: PANTHER Family
relationship type: By Homology

Probable citrate synthase, mitochondrial
type: ProteinReference
xref: uniprot P34575 31
organism: Caenorhabditis elegans

Fumarate hydratase, mitochondrial
type: ProteinReference
xref: PTHR11444:SF1
xref: uniprot P97807 89
organism: Mus musculus

uniprot Q9ER34 59
type: UnificationXref
id: Q9ER34
db: uniprot

cis-Aconitate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r6 156
type: Stoichiometry
physical entity: NADH+H+
stoichiometric coefficient: 1.0

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 25

PARTICIPANT STOICHIOMETRY r6 153
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 154
type: Stoichiometry
physical entity: IsoCitrate
stoichiometric coefficient: 1.0

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: uniprot E2R0Y5 102
xref: PTHR11117:SF2
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r6 155
type: Stoichiometry
physical entity: Oxalosuccinate
stoichiometric coefficient: 1.0

Succinate--CoA ligase [ADP-forming] subunit alpha
type: ProteinReference
xref: uniprot Q51567 110
xref: PTHR11117:SF2
organism: Pseudomonas aeruginosa

STATE_TRANSITION_LEFT__Citrate-RIGHT__cis_Aconitate-_H2O-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 152
left: Citrate
interaction type: STATE_TRANSITION
right: H2O
right: cis-Aconitate

uniprot P35487 17
type: UnificationXref
id: P35487
db: uniprot

uniprot A2DUL5 100
type: UnificationXref
id: A2DUL5
db: uniprot

ncbitaxon 243090 72
type: UnificationXref
id: 243090
db: ncbitaxon

Succinate Dehydrogenase
type: ProteinReference
xref: P01273
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Succinate Dehydrogenase Synonym: Synonym not specified Accession: P01273
comment: ENTITY_REFERENCE_ID_DESC=TCA cycle.PROTEIN.GENERIC.Succinate_br_Dehydrogenase
member entity reference: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
member entity reference: Succinate dehydrogenase complex subunit C
member entity reference: Succinate dehydrogenase cytochrome B subunit, mitochondrial
member entity reference: Uncharacterized protein

ncbitaxon 10090 16
type: UnificationXref
id: 10090
db: ncbitaxon

Citrate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q8VHF5 40
organism: Rattus norvegicus

ncbitaxon 9606 13
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot F7AM02 6
type: UnificationXref
id: F7AM02
db: uniprot

ncbitaxon 3702 75
type: UnificationXref
id: 3702
db: ncbitaxon

ncbitaxon 559292 28
type: UnificationXref
id: 559292
db: ncbitaxon

Oxaloacetate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

NADH+H+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 32

uniprot Q7XDC8 78
type: UnificationXref
id: Q7XDC8
db: uniprot

coA
type: Protein
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 243231 55
type: UnificationXref
id: 243231
db: ncbitaxon

STATE_TRANSITION_LEFT__Succinate-_FAD-RIGHT__FADH2-_Fumarate-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 135
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 136
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 133
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 134
left: FAD
left: Succinate
interaction type: STATE_TRANSITION
right: FADH2
right: Fumarate

ncbitaxon 7227 42
type: UnificationXref
id: 7227
db: ncbitaxon

alphaKetoglutarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A1D5QTZ3 93
type: UnificationXref
id: A0A1D5QTZ3
db: uniprot

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: PTHR11117:SF2
xref: uniprot Q9WUM5 113
organism: Mus musculus

Malate Dehydrogenase
type: Protein
entity reference: Malate Dehydrogenase
comment: SPECIES_TYPE=PROTEIN

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: uniprot Q9VIE8 60
organism: Drosophila melanogaster

Malate dehydrogenase 2, cytoplasmic
type: ProteinReference
xref: uniprot P57106 74
xref: PTHR23382:SF3
organism: Arabidopsis thaliana

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Succinate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aconitate hydratase, mitochondrial
type: ProteinReference
xref: uniprot Q99KI0 58
organism: Mus musculus

uniprot P29803 14
type: UnificationXref
id: P29803
db: uniprot

uniprot P34575 31
type: UnificationXref
id: P34575
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__coA__PLUS__NAD_PLUS_-_Pyruvate-RIGHT__Acetyl_CoA-_CO2_PLUS__NADH-_r24
controller: Pyruvate Dehydrogenase

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Citrate Synthase
type: Protein
entity reference: Citrate Synthase
comment: SPECIES_TYPE=PROTEIN

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 47

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 79

Malate dehydrogenase
type: ProteinReference
xref: PTHR23382:SF0
xref: uniprot Q8F4A2 80
organism: Leptospira interrogans

PARTICIPANT STOICHIOMETRY r17 140
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 111

2-oxoglutarate dehydrogenase E1 component
type: ProteinReference
xref: uniprot P23129 64
xref: PTHR23152:SF4
organism: Bacillus subtilis

uniprot Q9WUM5 113
type: UnificationXref
id: Q9WUM5
db: uniprot