Growth/differentiation factor 11
type: ProteinReference
xref: uniprot Q9Z217 702
xref: PTHR11848:SF166
organism: Rattus norvegicus

Glial cell line-derived neurotrophic factor
type: ProteinReference
xref: PTHR12173:SF1
xref: uniprot P39905 616
organism: Homo sapiens

uniprot F1R3A6 721
type: UnificationXref
id: F1R3A6
db: uniprot

uniprot P55103 628
type: UnificationXref
id: P55103
db: uniprot

TGFbetareceptor II s13 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetareceptor II
stoichiometric coefficient: 1.0

SKI proto-oncogene
type: ProteinReference
xref: uniprot A0A0G2K628 295
xref: PTHR10005:SF15
organism: Rattus norvegicus

ncbitaxon 214684 256
type: UnificationXref
id: 214684
db: ncbitaxon

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot Q7QE97 113
xref: PTHR23255:SF98
organism: Anopheles gambiae

uniprot P16951 359
type: UnificationXref
id: P16951
db: uniprot

uniprot F1MF35 481
type: UnificationXref
id: F1MF35
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 3

TGFbeta
type: Protein
entity reference: TGFbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa3 907
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P20792 97
type: UnificationXref
id: P20792
db: uniprot

Histone acetyltransferase HAC4
type: ProteinReference
xref: PTHR13808:SF30
xref: uniprot Q9LG11 394
organism: Arabidopsis thaliana

Complex (TGFbetareceptor I/TGFbetareceptor II/ TGF_beta)
type: Complex
component stoichiometry: TGFbetareceptor II s13 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: TGFbeta s14 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: TGFbetareceptor I s12 sa1 STOICHIOMETRY ID COMPLEX
component: TGFbetareceptor I
component: TGFbetareceptor II
component: TGFbeta
feature: COMPLEX BINDING FEATURE s36 a39 904
feature: COMPLEX BINDING FEATURE s36 a39 902
feature: COMPLEX BINDING FEATURE s36 a39 906
cellular location: cytosol

uniprot A5D7R9 208
type: UnificationXref
id: A5D7R9
db: uniprot

uniprot A0A3Q2TY19 403
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

BAMBI
type: ProteinReference
xref: P01287
standard name: BMP and activin membrane-bound inhibitor
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.RECEPTOR.BAMBI
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: BMP and activin membrane-bound inhibitor homolog

uniprot Q8QGU2 752
type: UnificationXref
id: Q8QGU2
db: uniprot

uniprot F7ESG8 146
type: UnificationXref
id: F7ESG8
db: uniprot

uniprot F1P630 406
type: UnificationXref
id: F1P630
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 27

uniprot Q754K8 744
type: UnificationXref
id: Q754K8
db: uniprot

Dwarfin sma
type: ProteinReference
xref: uniprot G5EDS9 798
organism: Caenorhabditis elegans

uniprot Q99717 829
type: UnificationXref
id: Q99717
db: uniprot

uniprot A0A3Q1LTT9 8
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P28482 858
organism: Homo sapiens

uniprot Q9DDW4 388
type: UnificationXref
id: Q9DDW4
db: uniprot

uniprot F1PMN2 407
type: UnificationXref
id: F1PMN2
db: uniprot

uniprot P17246 595
type: UnificationXref
id: P17246
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 843
organism: Canis lupus familiaris

uniprot Q9I8V2 830
type: UnificationXref
id: Q9I8V2
db: uniprot

PARTICIPANT STOICHIOMETRY r26 937
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

uniprot F7C798 22
type: UnificationXref
id: F7C798
db: uniprot

Mothers against decapentaplegic homolog
type: DnaReference
xref: PTHR13703:SF28
organism: Pan troglodytes

ncbitaxon 243230 754
type: UnificationXref
id: 243230
db: ncbitaxon

Left-right determination factor
type: ProteinReference
xref: PTHR11848:SF226
xref: uniprot F6VUD5 506
organism: Macaca mulatta

Mothers against decapentaplegic homolog 4
type: ProteinReference
xref: PTHR13703:SF45
xref: uniprot O70437 65
organism: Rattus norvegicus

Mothers against decapentaplegic homolog 2
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot O70436 804
organism: Rattus norvegicus

uniprot P45984 419
type: UnificationXref
id: P45984
db: uniprot

Mothers against decapentaplegic homolog 7
type: ProteinReference
xref: uniprot O88406 769
xref: PTHR13703:SF44
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r26 936
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

Anti-Muellerian hormone type-2 receptor
type: ProteinReference
xref: uniprot Q16671 109
xref: PTHR23255:SF49
organism: Homo sapiens

RSmads
type: Protein
entity reference: RSmads
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa10 901
feature: RSmads s9 sa10 rs2
feature: RSmads s9 sa10 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q8IZD4 376
type: UnificationXref
id: Q8IZD4
db: uniprot

uniprot F1MAE8 480
type: UnificationXref
id: F1MAE8
db: uniprot

ncbitaxon 6669 221
type: UnificationXref
id: 6669
db: ncbitaxon

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 856
organism: Homo sapiens

LAG1 longevity assurance homolog 1 isoform 1
type: ProteinReference
xref: PTHR11848:SF242
xref: uniprot F6ZBU9 509
organism: Macaca mulatta

Growth/differentiation factor 9
type: ProteinReference
xref: uniprot Q9GK68 683
xref: PTHR11848:SF19
organism: Bos taurus

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 261

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot Q1JQA2 818
organism: Bos taurus

uniprot F7A1M2 57
type: UnificationXref
id: F7A1M2
db: uniprot

uniprot F1QDT8 493
type: UnificationXref
id: F1QDT8
db: uniprot

Transforming growth factor beta
type: ProteinReference
xref: uniprot F6ZYQ1 512
xref: PTHR11848:SF141
organism: Xenopus tropicalis

Dauer larva development regulatory growth factor daf-7
type: ProteinReference
xref: uniprot P92172 637
xref: PTHR11848:SF262
organism: Caenorhabditis elegans

uniprot Q7QK91 281
type: UnificationXref
id: Q7QK91
db: uniprot

ncbitaxon 284812 254
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot P45983 418
type: UnificationXref
id: P45983
db: uniprot

NRAS protein
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot A5D7R9 208
organism: Bos taurus

Zinc finger FYVE domain-containing protein
type: ProteinReference
xref: PTHR46319:SF2
xref: uniprot F6UTI1 286
organism: Canis lupus familiaris

Growth/differentiation factor 7
type: ProteinReference
xref: uniprot Q7Z4P5 669
xref: PTHR11848:SF160
organism: Homo sapiens

uniprot B0JYL0 56
type: UnificationXref
id: B0JYL0
db: uniprot

uniprot O60383 575
type: UnificationXref
id: O60383
db: uniprot

PTHR13832:SF533
type: RelationshipXref
id: PTHR13832:SF533
db: PANTHER Family
relationship type: By Homology

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot A0A0G2K612 183
xref: PTHR11254:SF293
organism: Rattus norvegicus

uniprot A7F871 209
type: UnificationXref
id: A7F871
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot O42376 30
xref: PTHR24055:SF146
organism: Danio rerio

uniprot Q62381 656
type: UnificationXref
id: Q62381
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot B3DJ37 127
xref: PTHR23255:SF22
organism: Danio rerio

uniprot F6R871 82
type: UnificationXref
id: F6R871
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P79737 267
organism: Danio rerio

uniprot A0A0G2JVK0 294
type: UnificationXref
id: A0A0G2JVK0
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene Transcription
controller: p42/p44MAPKs

Inhibin beta B chain
type: ProteinReference
xref: uniprot A0A3Q1LMU4 453
xref: PTHR11848:SF29
organism: Bos taurus

uniprot H2QPW8 155
type: UnificationXref
id: H2QPW8
db: uniprot

uniprot F7BDU6 58
type: UnificationXref
id: F7BDU6
db: uniprot

uniprot Q62893 112
type: UnificationXref
id: Q62893
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF53
xref: uniprot A0A2I3TN10 780
organism: Pan troglodytes

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F6Y0Z8 792
xref: PTHR13703:SF41
organism: Ornithorhynchus anatinus

Growth differentiation factor 1
type: ProteinReference
xref: PTHR11848:SF259
xref: uniprot F6UHX6 504
organism: Xenopus tropicalis

uniprot P58166 634
type: UnificationXref
id: P58166
db: uniprot

uniprot P83100 38
type: UnificationXref
id: P83100
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9U3L3 429
organism: Caenorhabditis elegans

Ras protein let-60
type: ProteinReference
xref: uniprot P22981 262
xref: PTHR24070:SF420
organism: Caenorhabditis elegans

uniprot O93602 349
type: UnificationXref
id: O93602
db: uniprot

P38
type: Protein
entity reference: P38
feature: ACTIVE 54
feature: P38 s70 a81 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2QS99 555
type: UnificationXref
id: H2QS99
db: uniprot

uniprot F6YCR1 794
type: UnificationXref
id: F6YCR1
db: uniprot

uniprot A0A2I3TT58 773
type: UnificationXref
id: A0A2I3TT58
db: uniprot

uniprot F1M3F2 187
type: UnificationXref
id: F1M3F2
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF53
xref: uniprot Q8AY15 827
organism: Danio rerio

uniprot F1PQT6 192
type: UnificationXref
id: F1PQT6
db: uniprot

uniprot O95393 581
type: UnificationXref
id: O95393
db: uniprot

uniprot D4A670 467
type: UnificationXref
id: D4A670
db: uniprot

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot F1PHV7 229
organism: Canis lupus familiaris

Stress-activated protein kinase jnk-1
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot Q8WQG9 426
organism: Caenorhabditis elegans

Cited2/melanocyte specific gene-related gene 1 MRG1
type: ProteinReference
xref: PTHR17045:SF7
xref: uniprot Q9DDW4 388
organism: Gallus gallus

uniprot Q06826 642
type: UnificationXref
id: Q06826
db: uniprot

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: PTHR15505:SF1
xref: uniprot F7CL00 708
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q2TY19 403
organism: Gallus gallus

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q5Z859 871
organism: Oryza sativa

uniprot P53779 422
type: UnificationXref
id: P53779
db: uniprot

NRAS isoform 1
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot H2PZQ7 237
organism: Pan troglodytes

uniprot O35740 345
type: UnificationXref
id: O35740
db: uniprot

uniprot F7FG01 333
type: UnificationXref
id: F7FG01
db: uniprot

uniprot O95972 582
type: UnificationXref
id: O95972
db: uniprot

uniprot A0A2I3RDV4 298
type: UnificationXref
id: A0A2I3RDV4
db: uniprot

uniprot Q9W5Q1 396
type: UnificationXref
id: Q9W5Q1
db: uniprot

ncbitaxon 9598 47
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot Q9DGD9 428
type: UnificationXref
id: Q9DGD9
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 46
xref: PTHR24055:SF110
organism: Pan troglodytes

PTHR45645:SF15
type: RelationshipXref
id: PTHR45645:SF15
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Smurfs-_RSmads-RIGHT__Complex__Smurfs_RSmads_-_r31
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 919
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 920
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 918
left: RSmads
left: Smurfs
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Smurfs/RSmads)

uniprot Q61288 177
type: UnificationXref
id: Q61288
db: uniprot

Evidence 626
type: Evidence
evidence code: IGI
comment: Website http://flybase.org/reports/FBgn0005590.html

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q63844 872
xref: PTHR24055:SF393
organism: Mus musculus

CITED1 isoform 1
type: ProteinReference
xref: uniprot A0A2J8IVZ1 300
xref: PTHR17045:SF6
organism: Pan troglodytes

uniprot D3ZZR9 719
type: UnificationXref
id: D3ZZR9
db: uniprot

uniprot Q15759 39
type: UnificationXref
id: Q15759
db: uniprot

TAK s67 a77 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6ZJT0 510
type: UnificationXref
id: F6ZJT0
db: uniprot

PTHR45645:SF29
type: RelationshipXref
id: PTHR45645:SF29
db: PANTHER Family
relationship type: By Homology

PTHR45645:SF24
type: RelationshipXref
id: PTHR45645:SF24
db: PANTHER Family
relationship type: By Homology

PTHR45645:SF26
type: RelationshipXref
id: PTHR45645:SF26
db: PANTHER Family
relationship type: By Homology

Bone morphogenetic protein 4
type: ProteinReference
xref: uniprot Q2KJH1 653
xref: PTHR11848:SF165
organism: Bos taurus

ncbitaxon 8364 59
type: UnificationXref
id: 8364
db: ncbitaxon

Mitogen-activated protein kinase FUS3
type: ProteinReference
xref: uniprot P16892 854
organism: Saccharomyces cerevisiae

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot K6ZBV0 764
xref: PTHR13703:SF28
organism: Pan troglodytes

uniprot H2PZ11 287
type: UnificationXref
id: H2PZ11
db: uniprot

Evidence 205
type: Evidence
evidence code: TAS
comment: Website http://flybase.org/reports/FBgn0029006.html

uniprot E2R2N2 842
type: UnificationXref
id: E2R2N2
db: uniprot

TAB
type: Protein
entity reference: TAB
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GTP-binding protein Rheb homolog 1
type: ProteinReference
xref: uniprot P34443 266
organism: Caenorhabditis elegans

ncbitaxon 9031 76
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot F7H249 88
type: UnificationXref
id: F7H249
db: uniprot

Complex (Co-Smads/RSmads)
type: Complex
component stoichiometry: Co Smads s3 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: RSmads s4 sa5 STOICHIOMETRY ID COMPLEX
component: RSmads
component: Co-Smads
feature: COMPLEX BINDING FEATURE s46 a54 884
feature: COMPLEX BINDING FEATURE s46 a54 886
cellular location: cytosol

uniprot P22126 260
type: UnificationXref
id: P22126
db: uniprot

Growth/differentiation factor 8
type: ProteinReference
xref: uniprot O35312 570
xref: PTHR11848:SF150
organism: Rattus norvegicus

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q39024 867
organism: Arabidopsis thaliana

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F1NFN4 190
xref: PTHR11254:SF293
organism: Gallus gallus

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q39027 869
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q39026 868
organism: Arabidopsis thaliana

ncbitaxon 7165 69
type: UnificationXref
id: 7165
db: ncbitaxon

MODULATION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q39021 864
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q39023 866
organism: Arabidopsis thaliana

uniprot Q568M0 276
type: UnificationXref
id: Q568M0
db: uniprot

Mitogen-activated protein kinase 2
type: ProteinReference
xref: uniprot Q39022 865
organism: Arabidopsis thaliana

TRANSLATION_LEFT__I_SMAD-RIGHT__I_Smads-_re27
type: TemplateReaction
product: I-Smads
xref: TRANSLATION
participant: I-SMAD
participant: I-Smads
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot P57077 442
type: UnificationXref
id: P57077
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot Q62073 444
organism: Mus musculus

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot P08556 250
type: UnificationXref
id: P08556
db: uniprot

Nodal-related 1
type: ProteinReference
xref: PTHR11848:SF159
xref: uniprot F1QDT8 493
organism: Danio rerio

uniprot F1MT44 483
type: UnificationXref
id: F1MT44
db: uniprot

uniprot G5EDS9 798
type: UnificationXref
id: G5EDS9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2RA86 851
xref: PTHR24055:SF393
organism: Pan troglodytes

uniprot F7GHZ3 198
type: UnificationXref
id: F7GHZ3
db: uniprot

Co-activators corepressors
type: Protein
entity reference: Co-activators corepressors
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa8 897
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F7FDC0 523
type: UnificationXref
id: F7FDC0
db: uniprot

uniprot H2QLB4 850
type: UnificationXref
id: H2QLB4
db: uniprot

PTHR24070:SF206
type: RelationshipXref
id: PTHR24070:SF206
db: PANTHER Family
relationship type: By Homology

Co-activators corepressors
type: ProteinReference
xref: P01282
standard name: Co-activators or corepressors
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.Co-activators_br_corepressors
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Histone acetyltransferase HAC2
member entity reference: Transcription factor AP-1
member entity reference: Cited2/melanocyte specific gene-related gene 1 MRG1
member entity reference: JunB proto-oncogene, AP-1 transcription factor subunit
member entity reference: Uncharacterized protein
member entity reference: Transcription factor jun-B
member entity reference: CREB binding protein
member entity reference: Fos-related antigen 1
member entity reference: V-ski avian sarcoma viral oncogene homolog a
member entity reference: Forkhead box protein H1
member entity reference: Decapping protein 1, isoform A
member entity reference: E1A binding protein p300
member entity reference: CBP/p300-interacting transactivator
member entity reference: SKI proto-oncogene
member entity reference: FOS like 1, AP-1 transcription factor subunit
member entity reference: CITED2 isoform 4
member entity reference: Ski-like protein
member entity reference: SNIP1 isoform 1
member entity reference: Histone acetyltransferase HAC5
member entity reference: FOXH1 isoform 1
member entity reference: mRNA-decapping enzyme 1A
member entity reference: CITED1 isoform 1
member entity reference: Transcription factor jun-D
member entity reference: Cbp/p300-interacting transactivator 2
member entity reference: Histone acetyltransferase HAC12
member entity reference: SKI like proto-oncogene
member entity reference: CREB-binding protein
member entity reference: RE68879p
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit
member entity reference: Cbp/p300-interacting transactivator 3
member entity reference: Decapping mRNA 1A
member entity reference: Nuclear oncoprotein
member entity reference: Histone acetyltransferase HAC1
member entity reference: FHA domain-containing protein DDL
member entity reference: SKI-like proto-oncogene
member entity reference: Activating transcription factor 2
member entity reference: Histone acetyltransferase p300
member entity reference: Ski oncogene
member entity reference: Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
member entity reference: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
member entity reference: Histone acetyltransferase HAC4
member entity reference: Jun proto-oncogene
member entity reference: Forkhead box H1
member entity reference: CREB-binding protein isoform a
member entity reference: Cbp/p300-interacting transactivator 1

uniprot Q60698 374
type: UnificationXref
id: Q60698
db: uniprot

uniprot F7BH92 84
type: UnificationXref
id: F7BH92
db: uniprot

uniprot E2R326 784
type: UnificationXref
id: E2R326
db: uniprot

uniprot A9JRZ0 186
type: UnificationXref
id: A9JRZ0
db: uniprot

uniprot H2Q6B1 543
type: UnificationXref
id: H2Q6B1
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: PTHR23255:SF69
xref: uniprot A0A2I3SFK9 122
organism: Pan troglodytes

Metalloendopeptidase
type: ProteinReference
xref: uniprot H2QVU7 558
xref: PTHR45645:SF24
organism: Pan troglodytes

uniprot F1PKI6 320
type: UnificationXref
id: F1PKI6
db: uniprot

JNK
type: ProteinReference
xref: P01284
standard name: Jun-N-terminal kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.JNK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase 9
member entity reference: GLH-binding kinase 1
member entity reference: Stress-activated protein kinase JNK
member entity reference: Uncharacterized protein
member entity reference: Stress-activated protein kinase jnk-1

uniprot E2RB30 760
type: UnificationXref
id: E2RB30
db: uniprot

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: uniprot Q6GQM7 714
organism: Danio rerio

uniprot Q9WTU6 430
type: UnificationXref
id: Q9WTU6
db: uniprot

uniprot F6UTI1 286
type: UnificationXref
id: F6UTI1
db: uniprot

uniprot Q90669 115
type: UnificationXref
id: Q90669
db: uniprot

Bone morphogenetic protein 2
type: ProteinReference
xref: PTHR11848:SF143
xref: uniprot P12643 590
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6YAB9 20
xref: PTHR24055:SF110
organism: Monodelphis domestica

Bone morphogenetic protein 3
type: ProteinReference
xref: uniprot P12645 592
xref: PTHR11848:SF144
organism: Homo sapiens

Bone morphogenetic protein 4
type: ProteinReference
xref: uniprot P12644 591
xref: PTHR11848:SF165
organism: Homo sapiens

Protein mothers against dpp
type: ProteinReference
xref: PTHR13703:SF61
xref: uniprot P42003 807
organism: Drosophila melanogaster

uniprot Q61411 280
type: UnificationXref
id: Q61411
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QS62 415
xref: PTHR24055:SF172
organism: Pan troglodytes

uniprot P09529 588
type: UnificationXref
id: P09529
db: uniprot

uniprot Q6JHU9 375
type: UnificationXref
id: Q6JHU9
db: uniprot

uniprot P92172 637
type: UnificationXref
id: P92172
db: uniprot

uniprot Q21733 819
type: UnificationXref
id: Q21733
db: uniprot

uniprot Q63538 44
type: UnificationXref
id: Q63538
db: uniprot

uniprot P05627 351
type: UnificationXref
id: P05627
db: uniprot

uniprot H2PYQ7 536
type: UnificationXref
id: H2PYQ7
db: uniprot

uniprot P22004 605
type: UnificationXref
id: P22004
db: uniprot

uniprot Q9HAU4 202
type: UnificationXref
id: Q9HAU4
db: uniprot

uniprot A6QP91 457
type: UnificationXref
id: A6QP91
db: uniprot

uniprot E2R0W8 473
type: UnificationXref
id: E2R0W8
db: uniprot

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: PTHR15505:SF1
xref: uniprot Q9D0L6 716
organism: Mus musculus

uniprot K7DBC8 343
type: UnificationXref
id: K7DBC8
db: uniprot

Transforming growth factor beta-1 proprotein
type: ProteinReference
xref: uniprot P04202 583
xref: PTHR11848:SF125
organism: Mus musculus

Ras-like protein
type: ProteinReference
xref: uniprot Q12526 269
xref: PTHR24070:SF17
organism: Emericella nidulans

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A4FV00 404
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7CYE3 413
xref: PTHR24055:SF162
organism: Xenopus tropicalis

uniprot H2QKM7 552
type: UnificationXref
id: H2QKM7
db: uniprot

Transforming growth factor beta
type: ProteinReference
xref: PTHR11848:SF34
xref: uniprot Q66I23 658
organism: Danio rerio

uniprot F7B5L8 412
type: UnificationXref
id: F7B5L8
db: uniprot

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot F1R3A6 721
organism: Danio rerio

Ras-like protein 1
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot Q59XU5 277
organism: Candida albicans

ncbitaxon 44689 249
type: UnificationXref
id: 44689
db: ncbitaxon

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: uniprot P15336 357
xref: PTHR19304:SF9
organism: Homo sapiens

Cbp/p300-interacting transactivator 2
type: ProteinReference
xref: PTHR17045:SF7
xref: uniprot O35740 345
organism: Mus musculus

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF58
xref: uniprot H2QIU8 154
organism: Pan troglodytes

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot P70340 809
organism: Mus musculus

Inhibin subunit beta E
type: ProteinReference
xref: uniprot F6TA61 502
xref: PTHR11848:SF6
organism: Macaca mulatta

uniprot P17275 360
type: UnificationXref
id: P17275
db: uniprot

uniprot Q10N20 862
type: UnificationXref
id: Q10N20
db: uniprot

uniprot P34820 612
type: UnificationXref
id: P34820
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZTS0 21
xref: PTHR24055:SF146
organism: Macaca mulatta

Activin receptor type-1C
type: ProteinReference
xref: PTHR23255:SF58
xref: uniprot Q8NER5 181
organism: Homo sapiens

uniprot A0A0R4IZG7 119
type: UnificationXref
id: A0A0R4IZG7
db: uniprot

G01548
type: UnificationXref
id: G01548
db: PANTHER Pathway Component

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F1PY87 321
organism: Canis lupus familiaris

JNK
type: Protein
entity reference: JNK
feature: ACTIVE 54
feature: JNK s69 a82 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Growth/differentiation factor 6
type: ProteinReference
xref: uniprot Q6HA10 662
xref: PTHR11848:SF43
organism: Rattus norvegicus

uniprot P97769 369
type: UnificationXref
id: P97769
db: uniprot

Left-right determination factor 2
type: ProteinReference
xref: uniprot P57785 633
xref: PTHR11848:SF175
organism: Mus musculus

Mothers against decapentaplegic homolog 5
type: ProteinReference
xref: uniprot Q99717 829
xref: PTHR13703:SF36
organism: Homo sapiens

Uncharacterized protein rasD
type: ProteinReference
xref: PTHR24070:SF418
xref: uniprot F0ZB76 222
organism: Dictyostelium purpureum

uniprot P55108 632
type: UnificationXref
id: P55108
db: uniprot

TGFbetareceptor II
type: Protein
entity reference: TGFbetareceptor II
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa2 905
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P39905 616
type: UnificationXref
id: P39905
db: uniprot

uniprot P80202 168
type: UnificationXref
id: P80202
db: uniprot

uniprot Q9Z1W4 701
type: UnificationXref
id: Q9Z1W4
db: uniprot

Bone morphogenetic protein 2
type: ProteinReference
xref: uniprot P49001 622
xref: PTHR11848:SF143
organism: Rattus norvegicus

LD29161p
type: ProteinReference
xref: uniprot Q9V4F4 690
xref: PTHR11848:SF262
organism: Drosophila melanogaster

Bone morphogenetic protein 5
type: ProteinReference
xref: uniprot P49003 624
xref: PTHR11848:SF139
organism: Mus musculus

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot F7BH92 84
xref: PTHR23255:SF70
organism: Xenopus tropicalis

Bone morphogenetic protein 3
type: ProteinReference
xref: PTHR11848:SF144
xref: uniprot P49002 623
organism: Rattus norvegicus

uniprot D4A7P9 468
type: UnificationXref
id: D4A7P9
db: uniprot

uniprot Q6DIS7 824
type: UnificationXref
id: Q6DIS7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4XBC2 705
xref: PTHR11848:SF54
organism: Strongylocentrotus purpuratus

Univin
type: ProteinReference
xref: uniprot W4XBC1 703
xref: PTHR11848:SF54
organism: Strongylocentrotus purpuratus

Maverick
type: ProteinReference
xref: uniprot Q9V4E6 689
organism: Drosophila melanogaster

Left-right determination factor 1
type: ProteinReference
xref: uniprot O75610 577
xref: PTHR11848:SF257
organism: Homo sapiens

uniprot P12757 355
type: UnificationXref
id: P12757
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RSmads-RIGHT__RSmads-_r10
controller: SARA

uniprot F7CEL9 518
type: UnificationXref
id: F7CEL9
db: uniprot

Inhibin beta E chain
type: ProteinReference
xref: uniprot O08717 566
xref: PTHR11848:SF6
organism: Mus musculus

ncbitaxon 3055 879
type: UnificationXref
id: 3055
db: ncbitaxon

Growth/differentiation factor 11
type: ProteinReference
xref: PTHR11848:SF166
xref: uniprot Q9Z1W4 701
organism: Mus musculus

uniprot F7EVK3 331
type: UnificationXref
id: F7EVK3
db: uniprot

uniprot F6YA42 793
type: UnificationXref
id: F6YA42
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 848
organism: Monodelphis domestica

Mitogen-activated protein kinase p38b
type: ProteinReference
xref: uniprot O61443 32
xref: PTHR24055:SF238
organism: Drosophila melanogaster

12 kDa FK506-binding protein
type: ProteinReference
xref: uniprot P48375 735
organism: Drosophila melanogaster

uniprot P27090 608
type: UnificationXref
id: P27090
db: uniprot

uniprot A0A0D1C4Y4 835
type: UnificationXref
id: A0A0D1C4Y4
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot F6UPF6 791
organism: Ornithorhynchus anatinus

Activin receptor type-2A
type: ProteinReference
xref: uniprot P27038 99
xref: PTHR23255:SF64
organism: Mus musculus

Activin receptor type-2A
type: ProteinReference
xref: uniprot P27037 98
xref: PTHR23255:SF64
organism: Homo sapiens

SKI proto-oncogene
type: ProteinReference
xref: uniprot F1N727 316
xref: PTHR10005:SF15
organism: Bos taurus

uniprot P26885 733
type: UnificationXref
id: P26885
db: uniprot

Dorsal-ventral patterning protein tolloid
type: ProteinReference
xref: PTHR45645:SF8
xref: uniprot P25723 607
organism: Drosophila melanogaster

uniprot Q9BDI3 386
type: UnificationXref
id: Q9BDI3
db: uniprot

Mothers against decapentaplegic homolog
type: DnaReference
xref: PTHR13703:SF44
organism: Pan troglodytes

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot Q9V3Q6 445
organism: Drosophila melanogaster

uniprot F6YAB9 20
type: UnificationXref
id: F6YAB9
db: uniprot

BMP2 protein
type: ProteinReference
xref: uniprot A5PJI9 456
xref: PTHR11848:SF143
organism: Bos taurus

TRANSPORT
type: RelationshipTypeVocabulary

uniprot H2Q8N5 546
type: UnificationXref
id: H2Q8N5
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: uniprot P18870 364
xref: PTHR11462:SF8
organism: Gallus gallus

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 210

uniprot F6XMD4 722
type: UnificationXref
id: F6XMD4
db: uniprot

uniprot D4AE80 305
type: UnificationXref
id: D4AE80
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RSmads-RIGHT__RSmads-_r10
controller: Complex (TGFbetareceptor I/TGFbetareceptor II/ TGF_beta)

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F6XXN3 762
xref: PTHR13703:SF44
organism: Canis lupus familiaris

Ras-like protein rasB
type: ProteinReference
xref: uniprot P32252 263
xref: PTHR24070:SF206
organism: Dictyostelium discoideum

uniprot P01111 243
type: UnificationXref
id: P01111
db: uniprot

uniprot P04202 583
type: UnificationXref
id: P04202
db: uniprot

uniprot F6XXN3 762
type: UnificationXref
id: F6XXN3
db: uniprot

Ras-like protein rasS
type: ProteinReference
xref: uniprot P32254 265
xref: PTHR24070:SF380
organism: Dictyostelium discoideum

uniprot E2R3R6 435
type: UnificationXref
id: E2R3R6
db: uniprot

Ras-like protein rasC
type: ProteinReference
xref: PTHR24070:SF251
xref: uniprot P32253 264
organism: Dictyostelium discoideum

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot E2QW66 128
xref: PTHR23255:SF50
organism: Canis lupus familiaris

Evidence 291
type: Evidence
evidence code: TAS
comment: Website http://flybase.org/reports/FBgn0026369.html

RSmads
type: Protein
entity reference: RSmads
feature: ACTIVE 54
feature: RSmads s41 a42 rs1
feature: RSmads s41 a42 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P15064 259
type: UnificationXref
id: P15064
db: uniprot

uniprot P20863 600
type: UnificationXref
id: P20863
db: uniprot

Growth/differentiation factor 9
type: ProteinReference
xref: PTHR11848:SF19
xref: uniprot O60383 575
organism: Homo sapiens

uniprot Q7Z4P5 669
type: UnificationXref
id: Q7Z4P5
db: uniprot

PARTICIPANT STOICHIOMETRY r10 934
type: Stoichiometry
physical entity: RSmads
stoichiometric coefficient: 1.0

uniprot Q8I4E5 751
type: UnificationXref
id: Q8I4E5
db: uniprot

Nodal-related 2
type: ProteinReference
xref: PTHR11848:SF159
xref: uniprot A0A0R4IZE5 447
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r10 935
type: Stoichiometry
physical entity: RSmads
stoichiometric coefficient: 1.0

uniprot P10301 257
type: UnificationXref
id: P10301
db: uniprot

uniprot A0A1D5R6G4 72
type: UnificationXref
id: A0A1D5R6G4
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF58
xref: uniprot F6SV50 142
organism: Monodelphis domestica

uniprot E1B8D6 306
type: UnificationXref
id: E1B8D6
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot F7HPH2 89
xref: PTHR23255:SF64
organism: Macaca mulatta

Fos-related antigen 1
type: ProteinReference
xref: uniprot P15407 358
xref: PTHR23351:SF6
organism: Homo sapiens

uniprot Q9FYH1 390
type: UnificationXref
id: Q9FYH1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6T6T3 325
xref: PTHR11462:SF7
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BMX0 218
xref: PTHR24070:SF388
organism: Bos taurus

RSmads
type: Protein
entity reference: RSmads
feature: RSmads s39 a44 rs1
feature: RSmads s39 a44 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5PXC6 400
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

uniprot Q91XN4 715
type: UnificationXref
id: Q91XN4
db: uniprot

PARTICIPANT STOICHIOMETRY r14 928
type: Stoichiometry
physical entity: Complex (Co-activators corepressors/Co-Smads/ RSmads)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 927
type: Stoichiometry
physical entity: Complex (Co-Smads/RSmads)
stoichiometric coefficient: 1.0

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 272

uniprot O70437 65
type: UnificationXref
id: O70437
db: uniprot

Ras-related protein R-Ras
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot D3Z8L7 217
organism: Rattus norvegicus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

uniprot Q3T0N5 43
type: UnificationXref
id: Q3T0N5
db: uniprot

I-Smads
type: ProteinReference
xref: P01289
standard name: Inhibitory Smads
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.I-Smads
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mothers against decapentaplegic homolog 6
member entity reference: Mothers against decapentaplegic homolog 7
member entity reference: Mothers against decapentaplegic homolog

uniprot A0A1D5QN59 284
type: UnificationXref
id: A0A1D5QN59
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9Z1B7 53
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r14 926
type: Stoichiometry
physical entity: Co-activators corepressors
stoichiometric coefficient: 1.0

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot H2QEH9 799
organism: Pan troglodytes

Mothers against decapentaplegic homolog 6
type: DnaReference
xref: PTHR13703:SF28
organism: Mus musculus

uniprot P34545 366
type: UnificationXref
id: P34545
db: uniprot

Activin receptor type-1C
type: ProteinReference
xref: PTHR23255:SF58
xref: uniprot Q8K348 180
organism: Mus musculus

uniprot A0A0R4IAV4 296
type: UnificationXref
id: A0A0R4IAV4
db: uniprot

uniprot F7E905 330
type: UnificationXref
id: F7E905
db: uniprot

TAK
type: ProteinReference
xref: P01285
standard name: TGFbeta-activated kinase-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.TAK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase kinase 7
member entity reference: MAP3K7 C-terminal-like protein

Metalloendopeptidase
type: ProteinReference
xref: PTHR45645:SF26
xref: uniprot F7DZV7 520
organism: Monodelphis domestica

Peptidyl-prolyl cis-trans isomerase FKBP2
type: ProteinReference
xref: uniprot P26885 733
organism: Homo sapiens

Protein ras-1
type: ProteinReference
xref: uniprot P22126 260
xref: PTHR24070:SF17
organism: Neurospora crassa

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 17

Peptidyl-prolyl cis-trans isomerase FKBP1A
type: ProteinReference
xref: uniprot P26883 732
organism: Mus musculus

Activin receptor type-2B
type: ProteinReference
xref: PTHR23255:SF70
xref: uniprot P27040 100
organism: Mus musculus

FK506-binding protein 1
type: ProteinReference
xref: uniprot Q754K8 744
organism: Ashbya gossypii

TGFbetareceptor II
type: ProteinReference
xref: P01277
standard name: TGF-beta receptor type II
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.RECEPTOR.TGF_beta_receptor II
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Anti-Muellerian hormone type-2 receptor
member entity reference: Serine/threonine-protein kinase receptor
member entity reference: TGF-beta receptor type-2
member entity reference: Activin receptor type-2B
member entity reference: Receptor protein serine/threonine kinase
member entity reference: Serine/threonine-protein kinase sma-6
member entity reference: Activin receptor type-2A
member entity reference: Cell surface receptor daf-1
member entity reference: Cell surface receptor daf-4
member entity reference: Bone morphogenetic protein receptor type-2

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF44
xref: uniprot H2QEI2 763
organism: Pan troglodytes

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: uniprot P16951 359
xref: PTHR19304:SF9
organism: Mus musculus

uniprot F1N0X6 485
type: UnificationXref
id: F1N0X6
db: uniprot

Bone morphogenetic protein 4
type: ProteinReference
xref: uniprot F1PDL1 489
xref: PTHR11848:SF165
organism: Canis lupus familiaris

Bone morphogenetic protein 7
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot F7EZU0 522
organism: Ornithorhynchus anatinus

Serine/threonine-protein kinase receptor R3
type: ProteinReference
xref: PTHR23255:SF66
xref: uniprot P80203 169
organism: Rattus norvegicus

TGF-beta receptor type-1
type: ProteinReference
xref: uniprot P80204 170
xref: PTHR23255:SF61
organism: Rattus norvegicus

Bone morphogenetic protein 7
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot P18075 597
organism: Homo sapiens

Activin receptor type-1
type: ProteinReference
xref: uniprot P80201 167
xref: PTHR23255:SF69
organism: Rattus norvegicus

Activin receptor type-1B
type: ProteinReference
xref: uniprot P80202 168
xref: PTHR23255:SF22
organism: Rattus norvegicus

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot E2R3R6 435
organism: Canis lupus familiaris

uniprot P08476 587
type: UnificationXref
id: P08476
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF53
xref: uniprot Q66HX9 823
organism: Danio rerio

uniprot F7GUV7 524
type: UnificationXref
id: F7GUV7
db: uniprot

UNKNOWN_INHIBITION
type: Control
xref: UNKNOWN INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__TGFbetareceptors-_TGFbeta-RIGHT__Complex__TGFbetareceptor_I_TGFbetareceptor_II__TGF_beta_-_r9
control type: INHIBITION
controller: FKBP12

Related RAS viral (R-ras) oncogene homolog
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot Q2TBH2 274
organism: Bos taurus

uniprot P54631 625
type: UnificationXref
id: P54631
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 411
xref: PTHR24055:SF222
organism: Macaca mulatta

uniprot P18203 729
type: UnificationXref
id: P18203
db: uniprot

PTHR24070:SF245
type: RelationshipXref
id: PTHR24070:SF245
db: PANTHER Family
relationship type: By Homology

uniprot F1PKH2 490
type: UnificationXref
id: F1PKH2
db: uniprot

uniprot F5HEA9 844
type: UnificationXref
id: F5HEA9
db: uniprot

uniprot H2Q5Y6 153
type: UnificationXref
id: H2Q5Y6
db: uniprot

uniprot Q8F361 749
type: UnificationXref
id: Q8F361
db: uniprot

Protein CBR-RAS-1
type: ProteinReference
xref: uniprot A8XZ02 216
organism: Caenorhabditis briggsae

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F6QUG6 194
xref: PTHR11254:SF293
organism: Xenopus tropicalis

uniprot Q0VBZ5 371
type: UnificationXref
id: Q0VBZ5
db: uniprot

uniprot A4FV00 404
type: UnificationXref
id: A4FV00
db: uniprot

E3 ubiquitin-protein ligase SMURF2
type: ProteinReference
xref: PTHR11254:SF300
xref: uniprot Q9HAU4 202
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot G3X793 23
xref: PTHR24055:SF109
organism: Bos taurus

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF45
xref: uniprot H2QEJ6 62
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WV79 409
xref: PTHR24055:SF172
organism: Monodelphis domestica

Mothers against decapentaplegic homolog 2
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot Q62432 822
organism: Mus musculus

Forkhead box protein H1
type: ProteinReference
xref: uniprot O75593 346
xref: PTHR47316:SF1
organism: Homo sapiens

uniprot P37173 101
type: UnificationXref
id: P37173
db: uniprot

Protein CBR-LET-60
type: ProteinReference
xref: uniprot A8X0X5 213
xref: PTHR24070:SF420
organism: Caenorhabditis briggsae

Left-right determination factor
type: ProteinReference
xref: PTHR11848:SF181
xref: uniprot D4A670 467
organism: Rattus norvegicus

uniprot P27638 857
type: UnificationXref
id: P27638
db: uniprot

p42/p44MAPKs
type: Protein
entity reference: p42/p44MAPKs
feature: p42 p44MAPKs s60 a76 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q66I23 658
type: UnificationXref
id: Q66I23
db: uniprot

uniprot H2PZQ7 237
type: UnificationXref
id: H2PZQ7
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot E2RP23 786
organism: Canis lupus familiaris

Smurfs
type: Protein
entity reference: Smurfs
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Metalloendopeptidase
type: ProteinReference
xref: uniprot F6QUF3 498
xref: PTHR45645:SF15
organism: Xenopus tropicalis

uniprot F6ZWJ7 707
type: UnificationXref
id: F6ZWJ7
db: uniprot

PTHR15505:SF1
type: RelationshipXref
id: PTHR15505:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q9I9P9 831
type: UnificationXref
id: Q9I9P9
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F6SV95 143
xref: PTHR23255:SF69
organism: Xenopus tropicalis

uniprot Q07257 645
type: UnificationXref
id: Q07257
db: uniprot

uniprot H2QK94 551
type: UnificationXref
id: H2QK94
db: uniprot

uniprot F7FHD1 849
type: UnificationXref
id: F7FHD1
db: uniprot

uniprot P48755 368
type: UnificationXref
id: P48755
db: uniprot

uniprot O00292 564
type: UnificationXref
id: O00292
db: uniprot

Dwarfin sma
type: ProteinReference
xref: uniprot Q21733 819
xref: PTHR13703:SF25
organism: Caenorhabditis elegans

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 35
xref: PTHR24055:SF110
organism: Mus musculus

uniprot P16892 854
type: UnificationXref
id: P16892
db: uniprot

Inhibin beta E chain
type: ProteinReference
xref: uniprot O88959 578
xref: PTHR11848:SF6
organism: Rattus norvegicus

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 379

BMP7
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot Q6F2B8 661
organism: Xenopus tropicalis

uniprot F7F5X1 234
type: UnificationXref
id: F7F5X1
db: uniprot

uniprot A8X1S0 405
type: UnificationXref
id: A8X1S0
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P21708 855
xref: PTHR24055:SF393
organism: Rattus norvegicus

uniprot F7CYE3 413
type: UnificationXref
id: F7CYE3
db: uniprot

uniprot A0A2I3SUG7 452
type: UnificationXref
id: A0A2I3SUG7
db: uniprot

Transforming growth factor beta-2 proprotein
type: ProteinReference
xref: PTHR11848:SF141
xref: uniprot P27090 608
organism: Mus musculus

Inhibin beta A chain
type: ProteinReference
xref: uniprot P27092 610
xref: PTHR11848:SF133
organism: Gallus gallus

Growth/differentiation factor 2
type: ProteinReference
xref: PTHR11848:SF157
xref: uniprot Q9UK05 688
organism: Homo sapiens

uniprot D4A3U7 11
type: UnificationXref
id: D4A3U7
db: uniprot

Protein 60A
type: ProteinReference
xref: PTHR11848:SF263
xref: uniprot P27091 609
organism: Drosophila melanogaster

uniprot H2QS62 415
type: UnificationXref
id: H2QS62
db: uniprot

Transforming growth factor beta-2 proprotein
type: ProteinReference
xref: PTHR11848:SF141
xref: uniprot P61812 635
organism: Homo sapiens

RSmads s6 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RSmads
stoichiometric coefficient: 1.0

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot Q5VVH2 740
organism: Homo sapiens

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot A0A0R4IZG7 119
organism: Danio rerio

TGFbetareceptor I
type: ProteinReference
xref: P01278
standard name: TGF-beta receptor type I
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.RECEPTOR.TGF_beta_receptor I
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Activin receptor type-1
member entity reference: Receptor protein serine/threonine kinase
member entity reference: Serine/threonine-protein kinase sma-6
member entity reference: Serine/threonine-protein kinase receptor
member entity reference: Bone morphogenetic protein receptor type-1B
member entity reference: Activin receptor type-1B
member entity reference: Bone morphogenetic protein receptor type-1A
member entity reference: TGF-beta receptor type-1
member entity reference: Activin receptor type-1C
member entity reference: Serine/threonine-protein kinase receptor R3

Smad nuclear-interacting protein 1
type: ProteinReference
xref: PTHR23308:SF36
xref: uniprot Q8TAD8 377
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot F1MLT0 482
organism: Bos taurus

uniprot P14681 853
type: UnificationXref
id: P14681
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GS64 334
organism: Macaca mulatta

PTHR24070:SF251
type: RelationshipXref
id: PTHR24070:SF251
db: PANTHER Family
relationship type: By Homology

Danio rerio
type: BioSource
xref: ncbitaxon 7955 31

BMP6 isoform 1
type: ProteinReference
xref: PTHR11848:SF137
xref: uniprot H2QS99 555
organism: Pan troglodytes

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot F7CP27 797
organism: Macaca mulatta

Inhibin subunit beta A
type: ProteinReference
xref: uniprot E2QW13 472
xref: PTHR11848:SF133
organism: Canis lupus familiaris

uniprot Q2KJH1 653
type: UnificationXref
id: Q2KJH1
db: uniprot

Inhibin subunit beta A
type: ProteinReference
xref: PTHR11848:SF133
xref: uniprot F6SCP7 501
organism: Ornithorhynchus anatinus

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F1MLS5 188
xref: PTHR11254:SF293
organism: Bos taurus

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot Q63538 44
xref: PTHR24055:SF146
organism: Rattus norvegicus

TAK s61 a70 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot H2Q8B9 545
type: UnificationXref
id: H2Q8B9
db: uniprot

uniprot Q56IA0 821
type: UnificationXref
id: Q56IA0
db: uniprot

Bone morphogenetic protein 4
type: ProteinReference
xref: uniprot F1QAD6 492
xref: PTHR11848:SF165
organism: Danio rerio

uniprot P24898 365
type: UnificationXref
id: P24898
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1PPK6 137
xref: PTHR23255:SF22
organism: Canis lupus familiaris

uniprot A0A452DKC3 454
type: UnificationXref
id: A0A452DKC3
db: uniprot

E3 ubiquitin-protein ligase SMURF2
type: ProteinReference
xref: uniprot A2A5Z6 185
xref: PTHR11254:SF300
organism: Mus musculus

uniprot A0A2I3SJM1 74
type: UnificationXref
id: A0A2I3SJM1
db: uniprot

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 836

PARTICIPANT STOICHIOMETRY r32 917
type: Stoichiometry
physical entity: a92_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r32 916
type: Stoichiometry
physical entity: Complex (Smurfs/RSmads)
stoichiometric coefficient: 1.0

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: uniprot Q6F2E0 713
xref: PTHR15505:SF1
organism: Xenopus tropicalis

uniprot Q96S42 678
type: UnificationXref
id: Q96S42
db: uniprot

TAK
type: Protein
entity reference: TAK
feature: ACTIVE 54
feature: TAK s1 sa11 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa11 909
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q624 91
type: UnificationXref
id: H2Q624
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0D1C4Y4 835
organism: Ustilago maydis

Dorsalin-1
type: ProteinReference
xref: uniprot P34822 614
xref: PTHR11848:SF157
organism: Gallus gallus

uniprot F7CP27 797
type: UnificationXref
id: F7CP27
db: uniprot

uniprot P37023 164
type: UnificationXref
id: P37023
db: uniprot

RSmads s11 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RSmads
stoichiometric coefficient: 1.0

TGFbetareceptor I s12 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetareceptor I
stoichiometric coefficient: 1.0

uniprot H2QEJ6 62
type: UnificationXref
id: H2QEJ6
db: uniprot

Mitogen-activated protein kinase 5
type: ProteinReference
xref: uniprot Q10N20 862
organism: Oryza sativa

uniprot F7FU89 235
type: UnificationXref
id: F7FU89
db: uniprot

uniprot F6R9A9 499
type: UnificationXref
id: F6R9A9
db: uniprot

Growth/differentiation factor 8
type: ProteinReference
xref: uniprot O08689 565
xref: PTHR11848:SF150
organism: Mus musculus

uniprot B3DJ37 127
type: UnificationXref
id: B3DJ37
db: uniprot

Transcription factor jun-B
type: ProteinReference
xref: uniprot P09450 352
xref: PTHR11462:SF37
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot A2VDU3 434
organism: Bos taurus

Bone morphogenetic protein 15
type: ProteinReference
xref: PTHR11848:SF22
xref: uniprot Q6PX77 664
organism: Bos taurus

uniprot Q2TBH2 274
type: UnificationXref
id: Q2TBH2
db: uniprot

uniprot F7H957 526
type: UnificationXref
id: F7H957
db: uniprot

Complex (TAK/TAB)
type: Complex
component stoichiometry: TAB s2 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: TAK s1 sa11 STOICHIOMETRY ID COMPLEX
component: TAK
component: TAB
feature: COMPLEX BINDING FEATURE s68 a80 908
feature: COMPLEX BINDING FEATURE s68 a80 910
cellular location: cytosol

Transcription factor jun-D
type: ProteinReference
xref: uniprot P15066 356
xref: PTHR11462:SF7
organism: Mus musculus

Growth differentiation factor 11
type: ProteinReference
xref: PTHR11848:SF166
xref: uniprot F1MXM6 484
organism: Bos taurus

Ras-like protein rasG
type: ProteinReference
xref: uniprot P15064 259
xref: PTHR24070:SF17
organism: Dictyostelium discoideum

uniprot Q13145 711
type: UnificationXref
id: Q13145
db: uniprot

Stress-activated protein kinase JNK
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot P92208 424
organism: Drosophila melanogaster

GLH-binding kinase 1
type: ProteinReference
xref: uniprot O44408 417
organism: Caenorhabditis elegans

Histone acetyltransferase HAC12
type: ProteinReference
xref: uniprot Q9FWQ5 389
xref: PTHR13808:SF28
organism: Arabidopsis thaliana

CVg1 protein
type: ProteinReference
xref: PTHR11848:SF259
xref: uniprot Q98950 679
organism: Gallus gallus

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F1QEG9 193
xref: PTHR11254:SF293
organism: Danio rerio

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 12

Activating transcription factor 2
type: ProteinReference
xref: uniprot F7EVK3 331
xref: PTHR19304:SF9
organism: Monodelphis domestica

uniprot P27091 609
type: UnificationXref
id: P27091
db: uniprot

Bone morphogenetic protein 4
type: ProteinReference
xref: uniprot Q90752 675
xref: PTHR11848:SF165
organism: Gallus gallus

Bone morphogenetic protein 2 (Fragment)
type: ProteinReference
xref: uniprot Q90751 674
xref: PTHR11848:SF143
organism: Gallus gallus

Bone morphogenetic protein 7
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot Q9PTF9 685
organism: Danio rerio

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot P15066 356
type: UnificationXref
id: P15066
db: uniprot

INHIBITION
type: RelationshipTypeVocabulary

uniprot Q6Z437 874
type: UnificationXref
id: Q6Z437
db: uniprot

uniprot F7HJS7 149
type: UnificationXref
id: F7HJS7
db: uniprot

uniprot P20722 599
type: UnificationXref
id: P20722
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23351:SF6
xref: uniprot E1BNB5 308
organism: Bos taurus

uniprot F1PGW4 78
type: UnificationXref
id: F1PGW4
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F6YA42 793
xref: PTHR13703:SF23
organism: Ornithorhynchus anatinus

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: uniprot O93602 349
xref: PTHR19304:SF9
organism: Gallus gallus

uniprot F7APG6 515
type: UnificationXref
id: F7APG6
db: uniprot

STATE_TRANSITION_LEFT__p42_p44MAPKs-RIGHT__p42_p44MAPKs-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 915
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 914
left: p42/p44MAPKs
interaction type: STATE_TRANSITION
right: p42/p44MAPKs

Mothers against decapentaplegic homolog 6
type: DnaReference
xref: PTHR13703:SF28
organism: Homo sapiens

Mothers against decapentaplegic homolog 7
type: DnaReference
xref: PTHR13703:SF44
organism: Homo sapiens

uniprot F1MCE7 131
type: UnificationXref
id: F1MCE7
db: uniprot

E3 ubiquitin-protein ligase SMURF2
type: ProteinReference
xref: uniprot A9JRZ0 186
xref: PTHR11254:SF300
organism: Danio rerio

uniprot Q9WVM6 696
type: UnificationXref
id: Q9WVM6
db: uniprot

Zinc finger FYVE domain-containing protein
type: ProteinReference
evidence: Evidence 291
xref: PTHR46319:SF3
xref: uniprot Q7K9H6 290
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPB0 199
xref: PTHR11254:SF293
organism: Macaca mulatta

uniprot P12643 590
type: UnificationXref
id: P12643
db: uniprot

Transforming growth factor beta
type: ProteinReference
xref: PTHR11848:SF141
xref: uniprot F6ZJX4 511
organism: Macaca mulatta

RSmads s4 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RSmads
stoichiometric coefficient: 1.0

uniprot A8X0X5 213
type: UnificationXref
id: A8X0X5
db: uniprot

uniprot A2A5Z6 185
type: UnificationXref
id: A2A5Z6
db: uniprot

uniprot F7F4A2 60
type: UnificationXref
id: F7F4A2
db: uniprot

uniprot O95390 580
type: UnificationXref
id: O95390
db: uniprot

uniprot E1BE92 783
type: UnificationXref
id: E1BE92
db: uniprot

uniprot F6TKR2 503
type: UnificationXref
id: F6TKR2
db: uniprot

uniprot A2VDU3 434
type: UnificationXref
id: A2VDU3
db: uniprot

ncbitaxon 13616 17
type: UnificationXref
id: 13616
db: ncbitaxon

CBP/p300-interacting transactivator
type: ProteinReference
xref: uniprot Q90ZR5 380
xref: PTHR17045:SF5
organism: Danio rerio

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__Co_Smads-_RSmads-RIGHT__Complex__Co_Smads_RSmads_-_r12
control type: INHIBITION
controller: I-Smads

ncbitaxon 321614 845
type: UnificationXref
id: 321614
db: ncbitaxon

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot F7BRY9 85
xref: PTHR23255:SF70
organism: Monodelphis domestica

TGF-beta activated kinase 1 (MAP3K7) binding protein 1
type: ProteinReference
xref: uniprot F1PLP7 774
xref: PTHR13832:SF533
organism: Canis lupus familiaris

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 223

uniprot A0A2I3TN10 780
type: UnificationXref
id: A0A2I3TN10
db: uniprot

Bone morphogenetic protein 10
type: ProteinReference
xref: PTHR11848:SF39
xref: uniprot E2R889 474
organism: Canis lupus familiaris

E3 ubiquitin-protein ligase Smurf1
type: ProteinReference
evidence: Evidence 205
xref: uniprot Q9V853 204
xref: PTHR11254:SF395
organism: Drosophila melanogaster

uniprot K7DT43 344
type: UnificationXref
id: K7DT43
db: uniprot

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q503B6 275
organism: Danio rerio

uniprot O88621 348
type: UnificationXref
id: O88621
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P17325 361
organism: Rattus norvegicus

Serine/threonine-protein kinase receptor R3
type: ProteinReference
xref: PTHR23255:SF66
xref: uniprot Q61288 177
organism: Mus musculus

Bone morphogenetic protein 8A
type: ProteinReference
xref: uniprot P34821 613
xref: PTHR11848:SF119
organism: Mus musculus

Mothers against decapentaplegic homolog 9
type: ProteinReference
xref: PTHR13703:SF41
xref: uniprot Q9JIW5 832
organism: Mus musculus

GDF6 isoform 1
type: ProteinReference
xref: uniprot K7A0F7 563
xref: PTHR11848:SF43
organism: Pan troglodytes

Bone morphogenetic protein 8B
type: ProteinReference
xref: uniprot P34820 612
xref: PTHR11848:SF119
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__Co_activators_corepressors-_Complex__Co_Smads_RSmads_-RIGHT__Complex__Co_activators_corepressors_Co_Smads__RSmads_-_r14
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 926
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 928
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 927
left: Co-activators corepressors
left: Complex (Co-Smads/RSmads)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Co-activators corepressors/Co-Smads/ RSmads)

Smurfs s10 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smurfs
stoichiometric coefficient: 1.0

Growth/differentiation factor 8
type: ProteinReference
xref: PTHR11848:SF150
xref: uniprot O18836 569
organism: Bos taurus

SKI proto-oncogene
type: ProteinReference
xref: uniprot F1Q1E2 322
xref: PTHR10005:SF15
organism: Canis lupus familiaris

uniprot P36898 163
type: UnificationXref
id: P36898
db: uniprot

uniprot F7H4M7 525
type: UnificationXref
id: F7H4M7
db: uniprot

Mothers against decapentaplegic homolog 7
type: ProteinReference
xref: uniprot O15105 765
xref: PTHR13703:SF44
organism: Homo sapiens

uniprot F0ZVH9 225
type: UnificationXref
id: F0ZVH9
db: uniprot

Activin receptor type-1B
type: ProteinReference
xref: uniprot Q61271 176
xref: PTHR23255:SF22
organism: Mus musculus

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot Q9U2Q8 755
organism: Caenorhabditis elegans

Tolloid-like protein 1
type: ProteinReference
xref: PTHR45645:SF26
xref: uniprot O43897 573
organism: Homo sapiens

uniprot Q7NMC5 746
type: UnificationXref
id: Q7NMC5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F4C3 332
xref: PTHR23351:SF6
organism: Macaca mulatta

uniprot Q1HI69 649
type: UnificationXref
id: Q1HI69
db: uniprot

Mothers against decapentaplegic homolog 7
type: ProteinReference
xref: uniprot O35253 767
xref: PTHR13703:SF44
organism: Mus musculus

uniprot P18289 363
type: UnificationXref
id: P18289
db: uniprot

Nodal homolog
type: ProteinReference
xref: PTHR11848:SF159
xref: uniprot Q96S42 678
organism: Homo sapiens

uniprot F1N177 314
type: UnificationXref
id: F1N177
db: uniprot

uniprot Q9WV56 695
type: UnificationXref
id: Q9WV56
db: uniprot

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot Q6PBJ8 743
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GUV7 524
xref: PTHR11848:SF143
organism: Macaca mulatta

uniprot F7GDJ0 87
type: UnificationXref
id: F7GDJ0
db: uniprot

uniprot H2QRG9 554
type: UnificationXref
id: H2QRG9
db: uniprot

STATE_TRANSITION_LEFT__RSmads-RIGHT__RSmads-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 934
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 935
left: RSmads
interaction type: STATE_TRANSITION
right: RSmads

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot Q6PBJ1 742
organism: Danio rerio

uniprot E2QW13 472
type: UnificationXref
id: E2QW13
db: uniprot

Transforming growth factor beta-3 proprotein
type: ProteinReference
xref: PTHR11848:SF34
xref: uniprot P10600 589
organism: Homo sapiens

TAK
type: Protein
entity reference: TAK
feature: ACTIVE 54
feature: TAK s67 a77 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot A0A1D5Q7V1 779
organism: Macaca mulatta

PTHR47140:SF1
type: RelationshipXref
id: PTHR47140:SF1
db: PANTHER Family
relationship type: By Homology

Cbp/p300-interacting transactivator 1
type: ProteinReference
xref: PTHR17045:SF6
xref: uniprot Q9BDI3 386
organism: Bos taurus

Metalloendopeptidase
type: ProteinReference
xref: uniprot F7CB21 517
xref: PTHR45645:SF24
organism: Xenopus tropicalis

uniprot H2QGE0 548
type: UnificationXref
id: H2QGE0
db: uniprot

uniprot Q9DGE1 48
type: UnificationXref
id: Q9DGE1
db: uniprot

uniprot F1Q3H3 491
type: UnificationXref
id: F1Q3H3
db: uniprot

uniprot Q9PTF9 685
type: UnificationXref
id: Q9PTF9
db: uniprot

uniprot P45481 367
type: UnificationXref
id: P45481
db: uniprot

Metalloendopeptidase
type: ProteinReference
xref: uniprot F1M280 478
xref: PTHR45645:SF15
organism: Rattus norvegicus

Mitogen-activated protein kinase pmk-1
type: ProteinReference
xref: uniprot Q17446 41
xref: PTHR24055:SF238
organism: Caenorhabditis elegans

uniprot P97471 66
type: UnificationXref
id: P97471
db: uniprot

E3 ubiquitin-protein ligase SMURF1
type: ProteinReference
xref: uniprot Q9HCE7 203
xref: PTHR11254:SF293
organism: Homo sapiens

Mothers against decapentaplegic homolog 7
type: DnaReference
xref: PTHR13703:SF44
organism: Rattus norvegicus

uniprot Q9U3L3 429
type: UnificationXref
id: Q9U3L3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot F6ZJT0 510
organism: Macaca mulatta

uniprot P84023 811
type: UnificationXref
id: P84023
db: uniprot

Cbp/p300-interacting transactivator 2
type: ProteinReference
xref: PTHR17045:SF7
xref: uniprot Q0VCT9 372
organism: Bos taurus

uniprot H2Q5C7 541
type: UnificationXref
id: H2Q5C7
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F6S4W2 761
xref: PTHR13703:SF28
organism: Xenopus tropicalis

uniprot Q9UK05 688
type: UnificationXref
id: Q9UK05
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q95ME4 283
organism: Monodelphis domestica

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F7GHZ3 198
xref: PTHR11254:SF293
organism: Monodelphis domestica

uniprot P38445 104
type: UnificationXref
id: P38445
db: uniprot

uniprot H2QPS3 553
type: UnificationXref
id: H2QPS3
db: uniprot

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: uniprot K7AAP2 710
xref: PTHR15505:SF1
organism: Pan troglodytes

uniprot F7HPB0 199
type: UnificationXref
id: F7HPB0
db: uniprot

RSmads
type: ProteinReference
xref: P01292
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.RSmads
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mothers against decapentaplegic homolog
member entity reference: Mothers against decapentaplegic homolog 3
member entity reference: Dwarfin sma-2
member entity reference: Mothers against decapentaplegic homolog 9
member entity reference: Dwarfin sma-4
member entity reference: Mothers against decapentaplegic homolog 2
member entity reference: Mothers against decapentaplegic homolog 5
member entity reference: Mothers against decapentaplegic homolog 1
member entity reference: Dwarfin sma
member entity reference: Dwarfin sma (Fragment)
member entity reference: Protein mothers against dpp

ncbitaxon 665079 210
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot K6ZBV0 764
type: UnificationXref
id: K6ZBV0
db: uniprot

uniprot Q9R229 687
type: UnificationXref
id: Q9R229
db: uniprot

Activin receptor type-1
type: ProteinReference
xref: PTHR23255:SF69
xref: uniprot P37172 165
organism: Mus musculus

uniprot Q7Z3T8 293
type: UnificationXref
id: Q7Z3T8
db: uniprot

TGF-beta receptor type-2
type: ProteinReference
xref: PTHR23255:SF55
xref: uniprot P37173 101
organism: Homo sapiens

JNK s69 a82 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7EH19 847
type: UnificationXref
id: F7EH19
db: uniprot

uniprot A0A1D5QTT6 55
type: UnificationXref
id: A0A1D5QTT6
db: uniprot

uniprot A8XZ02 216
type: UnificationXref
id: A8XZ02
db: uniprot

TRANSLATION
type: RelationshipTypeVocabulary

uniprot Q20176 651
type: UnificationXref
id: Q20176
db: uniprot

I-SMAD
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q61831 425
xref: PTHR24055:SF162
organism: Mus musculus

uniprot Q90751 674
type: UnificationXref
id: Q90751
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot P0C8E4 441
organism: Rattus norvegicus

uniprot P27038 99
type: UnificationXref
id: P27038
db: uniprot

RSmads s9 sa10 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.04441521524691084
comment: MODIFICATION_RESIDUE_NAME=

uniprot F6ZKB3 411
type: UnificationXref
id: F6ZKB3
db: uniprot

Cbp/p300-interacting transactivator 1
type: ProteinReference
xref: PTHR17045:SF6
xref: uniprot P97769 369
organism: Mus musculus

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F7ESG8 146
xref: PTHR23255:SF22
organism: Xenopus tropicalis

Growth/differentiation factor 5
type: ProteinReference
xref: PTHR11848:SF44
xref: uniprot P43026 618
organism: Homo sapiens

Growth/differentiation factor 5
type: ProteinReference
xref: uniprot P43027 619
xref: PTHR11848:SF44
organism: Mus musculus

uniprot P08646 252
type: UnificationXref
id: P08646
db: uniprot

uniprot K7A0F7 563
type: UnificationXref
id: K7A0F7
db: uniprot

uniprot Q9GK68 683
type: UnificationXref
id: Q9GK68
db: uniprot

uniprot Q90999 116
type: UnificationXref
id: Q90999
db: uniprot

Nodal
type: ProteinReference
xref: PTHR11848:SF159
xref: uniprot P43021 617
organism: Mus musculus

uniprot Q8AY15 827
type: UnificationXref
id: Q8AY15
db: uniprot

uniprot Q1RMX1 712
type: UnificationXref
id: Q1RMX1
db: uniprot

uniprot Q9R1V3 833
type: UnificationXref
id: Q9R1V3
db: uniprot

uniprot Q9I9E1 392
type: UnificationXref
id: Q9I9E1
db: uniprot

uniprot F1QAD6 492
type: UnificationXref
id: F1QAD6
db: uniprot

ncbitaxon 45351 212
type: UnificationXref
id: 45351
db: ncbitaxon

Glial cell derived neurotrophic factor
type: ProteinReference
xref: uniprot F6S0Q2 500
xref: PTHR12173:SF1
organism: Bos taurus

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: uniprot E1AWU3 706
xref: PTHR15505:SF1
organism: Gallus gallus

RSmads s9 sa10 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot K7CW85 241
type: UnificationXref
id: K7CW85
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot O73736 158
xref: PTHR23255:SF96
organism: Danio rerio

Growth/differentiation factor 7
type: ProteinReference
xref: PTHR11848:SF160
xref: uniprot P43029 621
organism: Mus musculus

Growth/differentiation factor 6
type: ProteinReference
xref: PTHR11848:SF43
xref: uniprot P43028 620
organism: Mus musculus

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot F6S0Q9 788
organism: Monodelphis domestica

Bone morphogenetic protein 3
type: ProteinReference
xref: PTHR11848:SF144
xref: uniprot Q8BHE5 671
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot F7H6S1 438
organism: Macaca mulatta

uniprot G3V6W8 533
type: UnificationXref
id: G3V6W8
db: uniprot

Inhibin beta A chain
type: ProteinReference
xref: uniprot P07995 586
xref: PTHR11848:SF133
organism: Bos taurus

uniprot F7ACJ7 514
type: UnificationXref
id: F7ACJ7
db: uniprot

Transforming growth factor beta
type: ProteinReference
xref: uniprot F7HDK4 529
xref: PTHR11848:SF34
organism: Macaca mulatta

SNIP1 isoform 1
type: ProteinReference
xref: PTHR23308:SF36
xref: uniprot H2PYP1 336
organism: Pan troglodytes

Zinc finger FYVE domain-containing protein
type: ProteinReference
xref: PTHR46319:SF2
xref: uniprot H2PZ11 287
organism: Pan troglodytes

uniprot A0A2I3S7X1 121
type: UnificationXref
id: A0A2I3S7X1
db: uniprot

Mothers against decapentaplegic homolog 6
type: ProteinReference
xref: uniprot O43541 768
xref: PTHR13703:SF28
organism: Homo sapiens

Bone morphogenetic protein 10
type: ProteinReference
xref: PTHR11848:SF39
xref: uniprot E1B8X7 469
organism: Bos taurus

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
type: ProteinReference
xref: PTHR17045:SF7
xref: uniprot Q99MA1 385
organism: Rattus norvegicus

uniprot Q6PX77 664
type: UnificationXref
id: Q6PX77
db: uniprot

uniprot A0A2R8Q8S1 206
type: UnificationXref
id: A0A2R8Q8S1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q9FXT7 878
organism: Chlamydomonas reinhardtii

uniprot P49002 623
type: UnificationXref
id: P49002
db: uniprot

Nuclear oncoprotein
type: ProteinReference
xref: PTHR10005:SF24
xref: uniprot Q9YI02 397
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot H3FK05 238
organism: Pristionchus pacificus

Nodal growth differentiation factor
type: ProteinReference
xref: PTHR11848:SF159
xref: uniprot F7FDC0 523
organism: Macaca mulatta

uniprot P15407 358
type: UnificationXref
id: P15407
db: uniprot

uniprot E1B8T7 758
type: UnificationXref
id: E1B8T7
db: uniprot

Left-right determination factor 1
type: ProteinReference
xref: PTHR11848:SF181
xref: uniprot Q64280 657
organism: Mus musculus

uniprot O18836 569
type: UnificationXref
id: O18836
db: uniprot

Growth/differentiation factor 10
type: ProteinReference
xref: uniprot P97737 638
xref: PTHR11848:SF145
organism: Mus musculus

ncbitaxon 6239 42
type: UnificationXref
id: 6239
db: ncbitaxon

TGFbetareceptors
type: ProteinReference
xref: P01283
standard name: TGF-beta receptors
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.RECEPTOR.TGF_beta_receptors
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Activin receptor type-1
member entity reference: Anti-Muellerian hormone type-2 receptor
member entity reference: Receptor protein serine/threonine kinase
member entity reference: Activin receptor type-2B
member entity reference: Serine/threonine-protein kinase receptor
member entity reference: Activin receptor type-2A
member entity reference: Serine/threonine-protein kinase sma-6
member entity reference: Bone morphogenetic protein receptor type-1A
member entity reference: TGF-beta receptor type-2
member entity reference: Cell surface receptor daf-4
member entity reference: Activin receptor type-1B
member entity reference: Serine/threonine-protein kinase receptor R3
member entity reference: TGF-beta receptor type-1
member entity reference: Bone morphogenetic protein receptor type-2
member entity reference: Bone morphogenetic protein receptor type-1B

uniprot H2QEH9 799
type: UnificationXref
id: H2QEH9
db: uniprot

uniprot P54831 627
type: UnificationXref
id: P54831
db: uniprot

TAK s1 sa11 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ncbitaxon 237631 836
type: UnificationXref
id: 237631
db: ncbitaxon

uniprot P43028 620
type: UnificationXref
id: P43028
db: uniprot

uniprot P21214 601
type: UnificationXref
id: P21214
db: uniprot

Dwarfin sma
type: ProteinReference
xref: uniprot A8WS81 781
organism: Caenorhabditis briggsae

Anti-Muellerian hormone type-2 receptor
type: ProteinReference
xref: PTHR23255:SF49
xref: uniprot Q62893 112
organism: Rattus norvegicus

Metalloendopeptidase
type: ProteinReference
xref: PTHR45645:SF26
xref: uniprot A0A2I3SEI4 451
organism: Pan troglodytes

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot A0A2I3S7X1 121
xref: PTHR23255:SF61
organism: Pan troglodytes

uniprot Q98TU0 680
type: UnificationXref
id: Q98TU0
db: uniprot

Nodal growth differentiation factor
type: ProteinReference
xref: PTHR11848:SF159
xref: uniprot H2Q215 540
organism: Pan troglodytes

uniprot Q7ZVK8 876
type: UnificationXref
id: Q7ZVK8
db: uniprot

ncbitaxon 7227 33
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot P12644 591
type: UnificationXref
id: P12644
db: uniprot

uniprot D3ZTI5 465
type: UnificationXref
id: D3ZTI5
db: uniprot

uniprot Q9V4E6 689
type: UnificationXref
id: Q9V4E6
db: uniprot

ncbitaxon 7668 704
type: UnificationXref
id: 7668
db: ncbitaxon

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot Q06900 172
xref: PTHR23255:SF61
organism: Gallus gallus

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1PS63 138
xref: PTHR23255:SF61
organism: Canis lupus familiaris

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 841
organism: Bos taurus

uniprot E2R5G6 219
type: UnificationXref
id: E2R5G6
db: uniprot

Metalloendopeptidase
type: ProteinReference
xref: uniprot E2RJJ6 475
xref: PTHR45645:SF24
organism: Canis lupus familiaris

uniprot F6Z5N3 231
type: UnificationXref
id: F6Z5N3
db: uniprot

PARTICIPANT STOICHIOMETRY r12 931
type: Stoichiometry
physical entity: Co-Smads
stoichiometric coefficient: 1.0

uniprot F6S9J1 141
type: UnificationXref
id: F6S9J1
db: uniprot

PARTICIPANT STOICHIOMETRY r12 932
type: Stoichiometry
physical entity: RSmads
stoichiometric coefficient: 1.0

uniprot Q4AEG6 655
type: UnificationXref
id: Q4AEG6
db: uniprot

PARTICIPANT STOICHIOMETRY r12 933
type: Stoichiometry
physical entity: Complex (Co-Smads/RSmads)
stoichiometric coefficient: 1.0

SKI like proto-oncogene
type: ProteinReference
xref: PTHR10005:SF3
xref: uniprot H2QNQ5 339
organism: Pan troglodytes

TRANSLATION
type: InteractionVocabulary

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 61

Activating transcription factor 2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot A0A2I3RDV4 298
organism: Pan troglodytes

Southpaw (Fragment)
type: ProteinReference
xref: PTHR11848:SF159
xref: uniprot F1QX69 495
organism: Danio rerio

uniprot F1QNG4 230
type: UnificationXref
id: F1QNG4
db: uniprot

Activating transcription factor 2
type: ProteinReference
xref: uniprot F1N177 314
xref: PTHR19304:SF9
organism: Bos taurus

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F6TJ28 195
xref: PTHR11254:SF293
organism: Ornithorhynchus anatinus

uniprot P80201 167
type: UnificationXref
id: P80201
db: uniprot

uniprot F7HG73 148
type: UnificationXref
id: F7HG73
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF28
xref: uniprot E2RB30 760
organism: Canis lupus familiaris

uniprot Q9LG11 394
type: UnificationXref
id: Q9LG11
db: uniprot

uniprot C3Z3V6 461
type: UnificationXref
id: C3Z3V6
db: uniprot

Transforming growth factor beta-2 proprotein
type: ProteinReference
xref: PTHR11848:SF141
xref: uniprot P21214 601
organism: Bos taurus

INHBE isoform 2
type: ProteinReference
xref: uniprot H2Q6B2 544
xref: PTHR11848:SF6
organism: Pan troglodytes

uniprot P61812 635
type: UnificationXref
id: P61812
db: uniprot

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot H2QJT5 726
organism: Pan troglodytes

BAMBI
type: Protein
entity reference: BAMBI
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Activin receptor type-2A
type: ProteinReference
xref: uniprot Q28043 110
xref: PTHR23255:SF64
organism: Bos taurus

uniprot P26883 732
type: UnificationXref
id: P26883
db: uniprot

INHBC isoform 1
type: ProteinReference
xref: PTHR11848:SF130
xref: uniprot H2Q6B1 543
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7E823 846
organism: Monodelphis domestica

uniprot O43318 440
type: UnificationXref
id: O43318
db: uniprot

Activin receptor type-1
type: ProteinReference
xref: PTHR23255:SF69
xref: uniprot Q28041 175
organism: Bos taurus

Glial cell line-derived neurotrophic factor
type: ProteinReference
xref: PTHR12173:SF1
xref: uniprot Q98TU0 680
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot H2PYQ7 536
xref: PTHR11848:SF119
organism: Pan troglodytes

uniprot P70340 809
type: UnificationXref
id: P70340
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot E1B8T7 758
xref: PTHR13703:SF44
organism: Bos taurus

uniprot E2RIZ5 312
type: UnificationXref
id: E2RIZ5
db: uniprot

Zinc finger FYVE domain-containing protein
type: ProteinReference
xref: uniprot H2QR58 288
organism: Pan troglodytes

uniprot A8XG73 214
type: UnificationXref
id: A8XG73
db: uniprot

uniprot B0S7D7 301
type: UnificationXref
id: B0S7D7
db: uniprot

Zinc finger FYVE domain-containing protein 16
type: ProteinReference
xref: uniprot Q7Z3T8 293
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r24 942
type: Stoichiometry
physical entity: Complex (TAK/TAB)
stoichiometric coefficient: 1.0

PTHR11848:SF125
type: RelationshipXref
id: PTHR11848:SF125
db: PANTHER Family
relationship type: By Homology

Bone morphogenetic protein 8b
type: ProteinReference
xref: uniprot H2PYR2 537
xref: PTHR11848:SF119
organism: Pan troglodytes

uniprot Q9M1Z5 882
type: UnificationXref
id: Q9M1Z5
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 14

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF68
xref: uniprot Q9VMT1 182
organism: Drosophila melanogaster

uniprot F1M280 478
type: UnificationXref
id: F1M280
db: uniprot

uniprot O46680 157
type: UnificationXref
id: O46680
db: uniprot

IDA
type: EvidenceCodeVocabulary

P38
type: ProteinReference
xref: P01275
standard name: p38 mitogen activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.P38
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase pmk-2
member entity reference: Mitogen-activated protein kinase p38b
member entity reference: Mitogen-activated protein kinase p38a
member entity reference: Mitogen-activated protein kinase pmk-1
member entity reference: Mitogen-activated protein kinase 14B
member entity reference: Putative mitogen-activated protein kinase 14C
member entity reference: Mitogen-activated protein kinase 14A

PARTICIPANT STOICHIOMETRY r24 941
type: Stoichiometry
physical entity: TAB
stoichiometric coefficient: 1.0

uniprot F1MSQ2 134
type: UnificationXref
id: F1MSQ2
db: uniprot

uniprot H2QFT1 547
type: UnificationXref
id: H2QFT1
db: uniprot

PARTICIPANT STOICHIOMETRY r24 940
type: Stoichiometry
physical entity: TAK
stoichiometric coefficient: 1.0

uniprot Q7PNK1 667
type: UnificationXref
id: Q7PNK1
db: uniprot

Mothers against decapentaplegic homolog
type: DnaReference
xref: PTHR13703:SF28
organism: Canis lupus familiaris

uniprot P34822 614
type: UnificationXref
id: P34822
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene Transcription
controller: JNK

PTHR45645:SF8
type: RelationshipXref
id: PTHR45645:SF8
db: PANTHER Family
relationship type: By Homology

uniprot A0A0G2JZN0 446
type: UnificationXref
id: A0A0G2JZN0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BJ37 307
xref: PTHR10005:SF3
organism: Bos taurus

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot H2RCY2 439
organism: Pan troglodytes

ncbitaxon 10116 12
type: UnificationXref
id: 10116
db: ncbitaxon

PTHR11848:SF119
type: RelationshipXref
id: PTHR11848:SF119
db: PANTHER Family
relationship type: By Homology

uniprot Q15796 816
type: UnificationXref
id: Q15796
db: uniprot

PTHR11848:SF130
type: RelationshipXref
id: PTHR11848:SF130
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF132
type: RelationshipXref
id: PTHR11848:SF132
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF133
type: RelationshipXref
id: PTHR11848:SF133
db: PANTHER Family
relationship type: By Homology

Bone morphogenetic protein 2
type: ProteinReference
xref: uniprot P21274 602
xref: PTHR11848:SF143
organism: Mus musculus

uniprot G5EBY8 534
type: UnificationXref
id: G5EBY8
db: uniprot

Bone morphogenetic protein 4
type: ProteinReference
xref: uniprot P21275 603
xref: PTHR11848:SF165
organism: Mus musculus

PTHR11848:SF135
type: RelationshipXref
id: PTHR11848:SF135
db: PANTHER Family
relationship type: By Homology

Inhibin beta E chain
type: ProteinReference
xref: uniprot P58166 634
xref: PTHR11848:SF6
organism: Homo sapiens

PTHR11848:SF137
type: RelationshipXref
id: PTHR11848:SF137
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF139
type: RelationshipXref
id: PTHR11848:SF139
db: PANTHER Family
relationship type: By Homology

RSmads
type: Protein
entity reference: RSmads
feature: RSmads s6 sa7 rs2
feature: RSmads s6 sa7 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa7 891
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 847
organism: Xenopus tropicalis

uniprot F1P9Z4 228
type: UnificationXref
id: F1P9Z4
db: uniprot

uniprot Q28041 175
type: UnificationXref
id: Q28041
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot A0A3Q1LSA1 123
xref: PTHR23255:SF62
organism: Bos taurus

uniprot F6TU68 789
type: UnificationXref
id: F6TU68
db: uniprot

uniprot P63086 861
type: UnificationXref
id: P63086
db: uniprot

uniprot O62618 34
type: UnificationXref
id: O62618
db: uniprot

Ras-related protein Rab-10
type: ProteinReference
xref: uniprot Q94148 282
organism: Caenorhabditis elegans

uniprot Q16671 109
type: UnificationXref
id: Q16671
db: uniprot

uniprot P80203 169
type: UnificationXref
id: P80203
db: uniprot

PTHR11848:SF143
type: RelationshipXref
id: PTHR11848:SF143
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF141
type: RelationshipXref
id: PTHR11848:SF141
db: PANTHER Family
relationship type: By Homology

uniprot F6TJ28 195
type: UnificationXref
id: F6TJ28
db: uniprot

TGF-beta receptor type-2
type: ProteinReference
xref: PTHR23255:SF55
xref: uniprot F1PNA9 79
organism: Canis lupus familiaris

PTHR11848:SF145
type: RelationshipXref
id: PTHR11848:SF145
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF144
type: RelationshipXref
id: PTHR11848:SF144
db: PANTHER Family
relationship type: By Homology

uniprot E1BH37 759
type: UnificationXref
id: E1BH37
db: uniprot

uniprot Q94148 282
type: UnificationXref
id: Q94148
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11848:SF145
xref: uniprot F7HMT9 530
organism: Macaca mulatta

uniprot F6TXC2 16
type: UnificationXref
id: F6TXC2
db: uniprot

Bone morphogenetic protein 10
type: ProteinReference
xref: uniprot Q4AEG6 655
xref: PTHR11848:SF39
organism: Rattus norvegicus

uniprot Q9Z217 702
type: UnificationXref
id: Q9Z217
db: uniprot

Zinc finger FYVE domain-containing protein 9
type: ProteinReference
xref: PTHR46319:SF2
xref: uniprot O95405 289
organism: Homo sapiens

mRNA-decapping enzyme 1A
type: ProteinReference
xref: PTHR16290:SF4
xref: uniprot A0A1D5Q7U9 297
organism: Macaca mulatta

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P70618 37
xref: PTHR24055:SF110
organism: Rattus norvegicus

PTHR11848:SF151
type: RelationshipXref
id: PTHR11848:SF151
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF150
type: RelationshipXref
id: PTHR11848:SF150
db: PANTHER Family
relationship type: By Homology

uniprot Q08DX6 648
type: UnificationXref
id: Q08DX6
db: uniprot

Growth differentiation factor 5
type: ProteinReference
xref: PTHR11848:SF44
xref: uniprot H2QK94 551
organism: Pan troglodytes

eco ECO:0000304 25
type: UnificationXref
id: ECO:0000304
db: eco

PTHR11848:SF159
type: RelationshipXref
id: PTHR11848:SF159
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF157
type: RelationshipXref
id: PTHR11848:SF157
db: PANTHER Family
relationship type: By Homology

uniprot Q6F2E0 713
type: UnificationXref
id: Q6F2E0
db: uniprot

Bone morphogenetic protein receptor type-2
type: ProteinReference
xref: uniprot O35607 95
xref: PTHR23255:SF63
organism: Mus musculus

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F7F4A2 60
xref: PTHR13703:SF45
organism: Ornithorhynchus anatinus

uniprot F6UPF6 791
type: UnificationXref
id: F6UPF6
db: uniprot

Ras-GDP
type: Protein
entity reference: Ras-GDP
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1MIW7 132
type: UnificationXref
id: F1MIW7
db: uniprot

Mothers against decapentaplegic homolog 3
type: ProteinReference
xref: PTHR13703:SF53
xref: uniprot Q8BUN5 828
organism: Mus musculus

PTHR11848:SF165
type: RelationshipXref
id: PTHR11848:SF165
db: PANTHER Family
relationship type: By Homology

Putative mitogen-activated protein kinase 14C
type: ProteinReference
xref: uniprot P83100 38
xref: PTHR24055:SF238
organism: Drosophila melanogaster

PTHR11848:SF160
type: RelationshipXref
id: PTHR11848:SF160
db: PANTHER Family
relationship type: By Homology

uniprot P34821 613
type: UnificationXref
id: P34821
db: uniprot

uniprot F6SV50 142
type: UnificationXref
id: F6SV50
db: uniprot

uniprot E2RJJ6 475
type: UnificationXref
id: E2RJJ6
db: uniprot

uniprot P05412 350
type: UnificationXref
id: P05412
db: uniprot

Bmp2a protein
type: ProteinReference
xref: uniprot B3DI86 460
xref: PTHR11848:SF143
organism: Danio rerio

uniprot Q9VQG9 692
type: UnificationXref
id: Q9VQG9
db: uniprot

uniprot Q6F2B8 661
type: UnificationXref
id: Q6F2B8
db: uniprot

STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 937
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 936
left: JNK
interaction type: STATE_TRANSITION
right: JNK

TGF-beta receptor type-1
type: ProteinReference
xref: uniprot O46680 157
xref: PTHR23255:SF61
organism: Bos taurus

PTHR11848:SF166
type: RelationshipXref
id: PTHR11848:SF166
db: PANTHER Family
relationship type: By Homology

Co-activators corepressors
type: Protein
entity reference: Co-activators corepressors
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Metalloendopeptidase
type: ProteinReference
xref: PTHR45645:SF26
xref: uniprot F1N0X6 485
organism: Bos taurus

Growth/differentiation factor 6
type: ProteinReference
xref: uniprot Q6KF10 663
xref: PTHR11848:SF43
organism: Homo sapiens

uniprot E1B8X7 469
type: UnificationXref
id: E1B8X7
db: uniprot

uniprot A0A0U1RRU5 772
type: UnificationXref
id: A0A0U1RRU5
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot H2Q272 151
xref: PTHR23255:SF50
organism: Pan troglodytes

uniprot F1N727 316
type: UnificationXref
id: F1N727
db: uniprot

uniprot H2Q272 151
type: UnificationXref
id: H2Q272
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: PTHR23255:SF66
xref: uniprot H2Q5Y5 152
organism: Pan troglodytes

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

uniprot Q39027 869
type: UnificationXref
id: Q39027
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot A0A3Q1LJZ7 4
xref: PTHR24055:SF146
organism: Bos taurus

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot H2Q5Y6 153
xref: PTHR23255:SF22
organism: Pan troglodytes

Ski oncogene
type: ProteinReference
xref: uniprot Q60698 374
xref: PTHR10005:SF15
organism: Mus musculus

p42 p44MAPKs s60 a76 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=2.7469590936560997
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase pmk-2
type: ProteinReference
xref: uniprot Q8MXI4 45
xref: PTHR24055:SF154
organism: Caenorhabditis elegans

uniprot O42220 571
type: UnificationXref
id: O42220
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 69

RSmads s6 sa7 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

GTPase KRas
type: ProteinReference
xref: uniprot F6Z5N3 231
xref: PTHR24070:SF388
organism: Monodelphis domestica

p42/p44MAPKs
type: ProteinReference
xref: P01293
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.p42/p44MAPKs
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase 7
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase mpk-1
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase spk1
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase FUS3
member entity reference: Mitogen-activated protein kinase (Fragment)
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase 2
member entity reference: Mitogen-activated protein kinase 5
member entity reference: Mitogen-activated protein kinase KSS1
member entity reference: Mitogen-activated protein kinase 4
member entity reference: Mitogen-activated protein kinase 6

uniprot Q8NER5 181
type: UnificationXref
id: Q8NER5
db: uniprot

uniprot A0A1D5Q5Z6 837
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

uniprot A7STP5 211
type: UnificationXref
id: A7STP5
db: uniprot

uniprot O42376 30
type: UnificationXref
id: O42376
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F7GDJ0 87
xref: PTHR23255:SF49
organism: Macaca mulatta

uniprot F6RYL1 324
type: UnificationXref
id: F6RYL1
db: uniprot

Inhibin beta B chain
type: ProteinReference
xref: PTHR11848:SF29
xref: uniprot P17491 596
organism: Rattus norvegicus

uniprot A0A2J8IVZ1 300
type: UnificationXref
id: A0A2J8IVZ1
db: uniprot

uniprot H2QEI2 763
type: UnificationXref
id: H2QEI2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RSB0 15
xref: PTHR24055:SF146
organism: Canis lupus familiaris

JNK
type: Protein
entity reference: JNK
feature: JNK s64 a73 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2QT84 556
type: UnificationXref
id: H2QT84
db: uniprot

uniprot O95405 289
type: UnificationXref
id: O95405
db: uniprot

uniprot F6TKL3 408
type: UnificationXref
id: F6TKL3
db: uniprot

uniprot F6V332 18
type: UnificationXref
id: F6V332
db: uniprot

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

uniprot Q32PR5 654
type: UnificationXref
id: Q32PR5
db: uniprot

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: PTHR15505:SF1
xref: uniprot Q13145 711
organism: Homo sapiens

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot E2RA74 130
xref: PTHR23255:SF62
organism: Canis lupus familiaris

uniprot F7DZV7 520
type: UnificationXref
id: F7DZV7
db: uniprot

uniprot F7HNS7 150
type: UnificationXref
id: F7HNS7
db: uniprot

SKI-like proto-oncogene
type: ProteinReference
xref: PTHR10005:SF3
xref: uniprot D3ZWL1 304
organism: Rattus norvegicus

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05412 350
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9XXC0 431
organism: Caenorhabditis elegans

uniprot Q0IHM5 173
type: UnificationXref
id: Q0IHM5
db: uniprot

Decapping mRNA 1A
type: ProteinReference
xref: PTHR16290:SF4
xref: uniprot D4AE80 305
organism: Rattus norvegicus

RSmads s11 sa14 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot H2RCQ5 801
xref: PTHR13703:SF41
organism: Pan troglodytes

Ski oncogene
type: ProteinReference
xref: uniprot E1BSJ7 309
xref: PTHR10005:SF15
organism: Gallus gallus

PTHR16290:SF4
type: RelationshipXref
id: PTHR16290:SF4
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QUK7 120
type: UnificationXref
id: A0A1D5QUK7
db: uniprot

AGAP011934-PA
type: ProteinReference
xref: uniprot Q7PZI7 668
xref: PTHR11848:SF263
organism: Anopheles gambiae

PTHR10005:SF3
type: RelationshipXref
id: PTHR10005:SF3
db: PANTHER Family
relationship type: By Homology

uniprot O00238 156
type: UnificationXref
id: O00238
db: uniprot

uniprot O93369 579
type: UnificationXref
id: O93369
db: uniprot

uniprot Q5VVH2 740
type: UnificationXref
id: Q5VVH2
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PTHR13808:SF1
type: RelationshipXref
id: PTHR13808:SF1
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1PMN2 407
xref: PTHR24055:SF162
organism: Canis lupus familiaris

RSmads
type: Protein
entity reference: RSmads
feature: RSmads s11 sa14 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa14 895
feature: RSmads s11 sa14 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

RSmads s11 sa14 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.04441521524691084
comment: MODIFICATION_RESIDUE_NAME=

uniprot A0A1D5QYV0 450
type: UnificationXref
id: A0A1D5QYV0
db: uniprot

uniprot O75610 577
type: UnificationXref
id: O75610
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot F6U298 436
organism: Xenopus tropicalis

Left-right determination factor
type: ProteinReference
xref: PTHR11848:SF226
xref: uniprot A0A1D5PYT7 449
organism: Gallus gallus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7FHD1 849
organism: Monodelphis domestica

uniprot P68107 738
type: UnificationXref
id: P68107
db: uniprot

uniprot E2REG1 311
type: UnificationXref
id: E2REG1
db: uniprot

uniprot F7E823 846
type: UnificationXref
id: F7E823
db: uniprot

uniprot F1M798 479
type: UnificationXref
id: F1M798
db: uniprot

uniprot J9P401 562
type: UnificationXref
id: J9P401
db: uniprot

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot Q6JHU9 375
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RKA7 13
xref: PTHR24055:SF107
organism: Canis lupus familiaris

Bone morphogenetic protein 4
type: ProteinReference
xref: uniprot Q06826 642
xref: PTHR11848:SF165
organism: Rattus norvegicus

Ski-like protein
type: ProteinReference
xref: uniprot Q60665 373
xref: PTHR10005:SF3
organism: Mus musculus

uniprot P37172 165
type: UnificationXref
id: P37172
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F5HEA9 844
organism: Phaeosphaeria nodorum

uniprot P36897 162
type: UnificationXref
id: P36897
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1P3H0 136
xref: PTHR23255:SF50
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR11848:SF22
xref: uniprot F1NHC3 486
organism: Gallus gallus

uniprot F7A9J8 144
type: UnificationXref
id: F7A9J8
db: uniprot

uniprot F1R741 497
type: UnificationXref
id: F1R741
db: uniprot

PTHR47316:SF1
type: RelationshipXref
id: PTHR47316:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P36894 159
type: UnificationXref
id: P36894
db: uniprot

uniprot D3ZWC5 466
type: UnificationXref
id: D3ZWC5
db: uniprot

uniprot O35253 767
type: UnificationXref
id: O35253
db: uniprot

uniprot P27361 856
type: UnificationXref
id: P27361
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 29

PARTICIPANT STOICHIOMETRY r31 920
type: Stoichiometry
physical entity: Complex (Smurfs/RSmads)
stoichiometric coefficient: 1.0

uniprot P07995 586
type: UnificationXref
id: P07995
db: uniprot

uniprot Q17446 41
type: UnificationXref
id: Q17446
db: uniprot

Bone morphogenetic protein 15
type: ProteinReference
xref: uniprot E9PTU9 477
xref: PTHR11848:SF22
organism: Rattus norvegicus

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r9 924
type: Stoichiometry
physical entity: TGFbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 923
type: Stoichiometry
physical entity: TGFbetareceptors
stoichiometric coefficient: 1.0

Growth differentiation factor 7
type: ProteinReference
xref: PTHR11848:SF160
xref: uniprot F1MAE8 480
organism: Rattus norvegicus

Bone morphogenetic protein receptor type-1A
type: ProteinReference
xref: uniprot P36894 159
xref: PTHR23255:SF50
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A7F871 209
organism: Sclerotinia sclerotiorum

Activin receptor type-1B
type: ProteinReference
xref: uniprot P36896 161
xref: PTHR23255:SF22
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r9 925
type: Stoichiometry
physical entity: Complex (TGFbetareceptor I/TGFbetareceptor II/ TGF_beta)
stoichiometric coefficient: 1.0

Bone morphogenetic protein receptor type-1A
type: ProteinReference
xref: uniprot P36895 160
xref: PTHR23255:SF50
organism: Mus musculus

uniprot P48375 735
type: UnificationXref
id: P48375
db: uniprot

Bone morphogenetic protein receptor type-1B
type: ProteinReference
xref: PTHR23255:SF62
xref: uniprot P36898 163
organism: Mus musculus

TGF-beta receptor type-1
type: ProteinReference
xref: uniprot P36897 162
xref: PTHR23255:SF61
organism: Homo sapiens

uniprot F7EP21 724
type: UnificationXref
id: F7EP21
db: uniprot

Mothers against decapentaplegic homolog 5
type: ProteinReference
xref: uniprot Q56I99 820
xref: PTHR13703:SF36
organism: Gallus gallus

uniprot Q9DFZ0 717
type: UnificationXref
id: Q9DFZ0
db: uniprot

PARTICIPANT STOICHIOMETRY r31 918
type: Stoichiometry
physical entity: Smurfs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 919
type: Stoichiometry
physical entity: RSmads
stoichiometric coefficient: 1.0

uniprot Q5A1D3 870
type: UnificationXref
id: Q5A1D3
db: uniprot

Growth/differentiation factor 8
type: ProteinReference
xref: PTHR11848:SF150
xref: uniprot Q6UKZ8 666
organism: Canis lupus familiaris

uniprot Q59XU5 277
type: UnificationXref
id: Q59XU5
db: uniprot

Growth/differentiation factor 11
type: ProteinReference
xref: uniprot O95390 580
xref: PTHR11848:SF166
organism: Homo sapiens

uniprot G3V7Y6 335
type: UnificationXref
id: G3V7Y6
db: uniprot

ncbitaxon 227321 270
type: UnificationXref
id: 227321
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6Y4G8 410
xref: PTHR24055:SF222
organism: Canis lupus familiaris

uniprot H2R170 560
type: UnificationXref
id: H2R170
db: uniprot

Bone morphogenetic protein 10
type: ProteinReference
xref: PTHR11848:SF39
xref: uniprot O95393 581
organism: Homo sapiens

uniprot H2Q153 538
type: UnificationXref
id: H2Q153
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__TAK-_TAB-RIGHT__Complex__TAK_TAB_-_r24
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 941
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 940
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 942
left: TAK
left: TAB
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TAK/TAB)

Metalloendopeptidase
type: ProteinReference
xref: PTHR45645:SF24
xref: uniprot E1BEV7 470
organism: Bos taurus

ncbitaxon 7739 462
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot F6U5C5 327
type: UnificationXref
id: F6U5C5
db: uniprot

Dawdle, isoform A
type: ProteinReference
xref: PTHR11848:SF263
xref: uniprot Q9VQG9 692
organism: Drosophila melanogaster

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot P08642 251
organism: Gallus gallus

ncbitaxon 237561 278
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot H2QYM3 559
type: UnificationXref
id: H2QYM3
db: uniprot

Evidence 126
type: Evidence
evidence code: TAS
comment: Website http://www.reactome.org/

Evidence 125
type: Evidence
evidence code: TAS
comment: Website http://flybase.org/reports/FBgn0011300.html

Ras-like protein 1
type: ProteinReference
xref: uniprot P08647 253
organism: Schizosaccharomyces pombe

uniprot P0CQ42 255
type: UnificationXref
id: P0CQ42
db: uniprot

Ras-like protein 1
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P08646 252
organism: Drosophila melanogaster

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot Q2NKS8 739
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot F1NUT2 488
organism: Gallus gallus

uniprot Q9W7E7 834
type: UnificationXref
id: Q9W7E7
db: uniprot

TGF-beta receptor type-2
type: ProteinReference
xref: PTHR23255:SF55
xref: uniprot Q62312 111
organism: Mus musculus

Embryonic growth/differentiation factor 1
type: ProteinReference
xref: PTHR11848:SF151
xref: uniprot P27539 611
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6V332 18
xref: PTHR24055:SF110
organism: Macaca mulatta

uniprot A0A0B4K7J3 118
type: UnificationXref
id: A0A0B4K7J3
db: uniprot

uniprot G5EEL5 535
type: UnificationXref
id: G5EEL5
db: uniprot

uniprot P35621 615
type: UnificationXref
id: P35621
db: uniprot

TRANSCRIPTION
type: RelationshipTypeVocabulary

Anti-Muellerian hormone type-2 receptor
type: ProteinReference
xref: uniprot H2Q624 91
xref: PTHR23255:SF49
organism: Pan troglodytes

uniprot F1A411 227
type: UnificationXref
id: F1A411
db: uniprot

uniprot Q8K592 114
type: UnificationXref
id: Q8K592
db: uniprot

Complex (Co-activators corepressors/Co-Smads/ RSmads)
type: Complex
component stoichiometry: Co activators corepressors s7 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: RSmads s9 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Co Smads s8 sa9 STOICHIOMETRY ID COMPLEX
component: RSmads
component: Co-activators corepressors
component: Co-Smads
feature: COMPLEX BINDING FEATURE s56 a65 900
feature: COMPLEX BINDING FEATURE s56 a65 898
feature: COMPLEX BINDING FEATURE s56 a65 896
cellular location: nucleus

Mothers against decapentaplegic homolog 5
type: ProteinReference
xref: PTHR13703:SF59
xref: uniprot Q9W7E7 834
organism: Danio rerio

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot P50488 105
type: UnificationXref
id: P50488
db: uniprot

ncbitaxon 54126 239
type: UnificationXref
id: 54126
db: ncbitaxon

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot F1QNG4 230
organism: Danio rerio

DPP/BMP-Like
type: ProteinReference
xref: uniprot G5EEL5 535
xref: PTHR11848:SF54
organism: Caenorhabditis elegans

uniprot P34443 266
type: UnificationXref
id: P34443
db: uniprot

TGFbetareceptor I
type: Protein
entity reference: TGFbetareceptor I
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa1 903
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1NNP2 487
type: UnificationXref
id: F1NNP2
db: uniprot

uniprot H3FK05 238
type: UnificationXref
id: H3FK05
db: uniprot

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 25

Protein CBR-RAB-10
type: ProteinReference
xref: uniprot A8XG73 214
organism: Caenorhabditis briggsae

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot Q56IA0 821
organism: Gallus gallus

uniprot Q9U2Q8 755
type: UnificationXref
id: Q9U2Q8
db: uniprot

GDF9 isoform 4
type: ProteinReference
xref: PTHR11848:SF19
xref: uniprot H2QRG9 554
organism: Pan troglodytes

Tolloid-like protein 2
type: ProteinReference
xref: uniprot Q9WVM6 696
xref: PTHR45645:SF15
organism: Mus musculus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q6Z437 874
organism: Oryza sativa

uniprot O23236 852
type: UnificationXref
id: O23236
db: uniprot

uniprot Q90ZR5 380
type: UnificationXref
id: Q90ZR5
db: uniprot

uniprot Q8CF89 777
type: UnificationXref
id: Q8CF89
db: uniprot

Peptidylprolyl isomerase (Fragment)
type: ProteinReference
xref: uniprot F6YTY1 723
organism: Xenopus tropicalis

uniprot F6XHC4 329
type: UnificationXref
id: F6XHC4
db: uniprot

Bone morphogenetic protein 8b
type: ProteinReference
xref: PTHR11848:SF132
xref: uniprot D3ZWC5 466
organism: Rattus norvegicus

Peptidyl-prolyl cis-trans isomerase FKBP1B
type: ProteinReference
xref: uniprot Q9Z2I2 756
organism: Mus musculus

uniprot Q9V4F4 690
type: UnificationXref
id: Q9V4F4
db: uniprot

uniprot Q28BW9 652
type: UnificationXref
id: Q28BW9
db: uniprot

PTHR46319:SF2
type: RelationshipXref
id: PTHR46319:SF2
db: PANTHER Family
relationship type: By Homology

PTHR46319:SF3
type: RelationshipXref
id: PTHR46319:SF3
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: PTHR23255:SF70
xref: uniprot A0A2I3SJM1 74
organism: Pan troglodytes

Bone morphogenetic protein 1
type: ProteinReference
xref: uniprot P98063 639
xref: PTHR45645:SF24
organism: Mus musculus

uniprot P32254 265
type: UnificationXref
id: P32254
db: uniprot

uniprot Q9DGE2 49
type: UnificationXref
id: Q9DGE2
db: uniprot

uniprot Q6Q247 665
type: UnificationXref
id: Q6Q247
db: uniprot

uniprot F1MLS5 188
type: UnificationXref
id: F1MLS5
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q3T0N5 43
organism: Bos taurus

uniprot F6UHX6 504
type: UnificationXref
id: F6UHX6
db: uniprot

uniprot E2RKA7 13
type: UnificationXref
id: E2RKA7
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__P38-RIGHT__P38-_r25
controller: Complex (TAK/TAB)

uniprot F1NHC3 486
type: UnificationXref
id: F1NHC3
db: uniprot

uniprot P21708 855
type: UnificationXref
id: P21708
db: uniprot

ncbitaxon 6238 10
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot P97737 638
type: UnificationXref
id: P97737
db: uniprot

uniprot A0A1D5PYT7 449
type: UnificationXref
id: A0A1D5PYT7
db: uniprot

uniprot Q9LE42 393
type: UnificationXref
id: Q9LE42
db: uniprot

Activin receptor type-1
type: ProteinReference
xref: PTHR23255:SF69
xref: uniprot Q04771 171
organism: Homo sapiens

uniprot Q1RLX1 174
type: UnificationXref
id: Q1RLX1
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot F1NCI7 75
xref: PTHR23255:SF70
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot F7A479 513
organism: Monodelphis domestica

Growth differentiation factor 11
type: ProteinReference
xref: uniprot H2Q663 542
xref: PTHR11848:SF166
organism: Pan troglodytes

uniprot A0A0R4IKK9 399
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

Evidence 585
type: Evidence
evidence code: TAS
comment: Website http://flybase.org/reports/FBgn0000490.html

uniprot P62942 736
type: UnificationXref
id: P62942
db: uniprot

Zinc finger FYVE domain-containing protein
type: ProteinReference
xref: PTHR46319:SF2
xref: uniprot F1MKY4 285
organism: Bos taurus

uniprot E2R9R5 720
type: UnificationXref
id: E2R9R5
db: uniprot

uniprot F6Z923 508
type: UnificationXref
id: F6Z923
db: uniprot

uniprot K7AAP2 710
type: UnificationXref
id: K7AAP2
db: uniprot

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q28EW2 273
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot E9I1I7 220
xref: PTHR24070:SF420
organism: Daphnia pulex

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0R4IKK9 399
xref: PTHR24055:SF162
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2U980 207
organism: Gallus gallus

Growth differentiation factor 9
type: ProteinReference
xref: PTHR11848:SF19
xref: uniprot Q9QYW4 686
organism: Rattus norvegicus

uniprot F1QEG9 193
type: UnificationXref
id: F1QEG9
db: uniprot

Activin receptor type-2B
type: ProteinReference
xref: uniprot Q13705 107
xref: PTHR23255:SF70
organism: Homo sapiens

Candida albicans
type: BioSource
xref: ncbitaxon 237561 278

uniprot P20080 730
type: UnificationXref
id: P20080
db: uniprot

uniprot P01119 245
type: UnificationXref
id: P01119
db: uniprot

Smurfs
type: Protein
entity reference: Smurfs
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa13 893
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

uniprot P22981 262
type: UnificationXref
id: P22981
db: uniprot

uniprot A0A2I3SFK9 122
type: UnificationXref
id: A0A2I3SFK9
db: uniprot

uniprot F7EF57 197
type: UnificationXref
id: F7EF57
db: uniprot

uniprot A0A0G2K628 295
type: UnificationXref
id: A0A0G2K628
db: uniprot

Growth/differentiation factor 6-B
type: ProteinReference
xref: uniprot A8E7N9 458
xref: PTHR11848:SF228
organism: Danio rerio

Protein screw
type: ProteinReference
evidence: Evidence 626
xref: PTHR11848:SF263
xref: uniprot P54631 625
organism: Drosophila melanogaster

uniprot F6QUG6 194
type: UnificationXref
id: F6QUG6
db: uniprot

Activin receptor type-2A
type: ProteinReference
xref: uniprot Q90669 115
xref: PTHR23255:SF64
organism: Gallus gallus

uniprot F1MXM6 484
type: UnificationXref
id: F1MXM6
db: uniprot

uniprot F7H6S1 438
type: UnificationXref
id: F7H6S1
db: uniprot

uniprot F1NUT2 488
type: UnificationXref
id: F1NUT2
db: uniprot

uniprot P17125 594
type: UnificationXref
id: P17125
db: uniprot

uniprot P97454 813
type: UnificationXref
id: P97454
db: uniprot

uniprot A0A3Q1LSA1 123
type: UnificationXref
id: A0A3Q1LSA1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7F3M0 839
organism: Sclerotinia sclerotiorum

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

Co Smads s3 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Co-Smads
stoichiometric coefficient: 1.0

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 302

Co-Smads
type: Protein
entity reference: Co-Smads
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa9 899
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mothers against decapentaplegic homolog 5
type: ProteinReference
xref: PTHR13703:SF36
xref: uniprot Q9R1V3 833
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene Transcription
controller: P38

uniprot P55104 629
type: UnificationXref
id: P55104
db: uniprot

Tolloid-like protein 1
type: ProteinReference
xref: PTHR45645:SF26
xref: uniprot Q62381 656
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F7GN93 414
organism: Macaca mulatta

RSmads s6 sa7 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.04441521524691084
comment: MODIFICATION_RESIDUE_NAME=

Mothers against decapentaplegic homolog 9
type: ProteinReference
xref: uniprot O54835 803
xref: PTHR13703:SF41
organism: Rattus norvegicus

Tolloid-like protein 1
type: ProteinReference
xref: uniprot Q9DER7 682
xref: PTHR45645:SF26
organism: Gallus gallus

uniprot F6ZBU9 509
type: UnificationXref
id: F6ZBU9
db: uniprot

Fos-related antigen 1
type: ProteinReference
xref: PTHR23351:SF6
xref: uniprot P48755 368
organism: Mus musculus

uniprot O35607 95
type: UnificationXref
id: O35607
db: uniprot

ncbitaxon 7955 31
type: UnificationXref
id: 7955
db: ncbitaxon

Mothers against decapentaplegic homolog
type: DnaReference
xref: PTHR13703:SF28
organism: Xenopus tropicalis

uniprot O08717 566
type: UnificationXref
id: O08717
db: uniprot

uniprot A0A2I3S5B2 718
type: UnificationXref
id: A0A2I3S5B2
db: uniprot

RAS related
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot K7CW85 241
organism: Pan troglodytes

uniprot Q6DIZ6 825
type: UnificationXref
id: Q6DIZ6
db: uniprot

uniprot F0ZWE6 226
type: UnificationXref
id: F0ZWE6
db: uniprot

CITED2 isoform 4
type: ProteinReference
xref: PTHR17045:SF7
xref: uniprot A0A2I3SY88 299
organism: Pan troglodytes

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot H2R686 92
xref: PTHR23255:SF63
organism: Pan troglodytes

Anti-dorsalizing morphogenic protein
type: ProteinReference
xref: uniprot Q28BW9 652
xref: PTHR11848:SF241
organism: Xenopus tropicalis

Bone morphogenetic protein 7
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot P23359 606
organism: Mus musculus

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot Q15797 817
organism: Homo sapiens

uniprot Q9D0L6 716
type: UnificationXref
id: Q9D0L6
db: uniprot

Mothers against decapentaplegic homolog 2
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot Q15796 816
organism: Homo sapiens

uniprot P22003 604
type: UnificationXref
id: P22003
db: uniprot

Growth differentiation factor 5
type: ProteinReference
xref: uniprot F6X227 507
xref: PTHR11848:SF44
organism: Xenopus tropicalis

Bone morphogenetic protein 2
type: ProteinReference
xref: uniprot J9P401 562
xref: PTHR11848:SF143
organism: Canis lupus familiaris

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: PTHR23255:SF55
xref: uniprot G3MZV8 90
organism: Bos taurus

uniprot E1BJ37 307
type: UnificationXref
id: E1BJ37
db: uniprot

FOS like 1, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR23351:SF6
xref: uniprot K7DT43 344
organism: Pan troglodytes

uniprot P32253 264
type: UnificationXref
id: P32253
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P79996 423
xref: PTHR24055:SF172
organism: Gallus gallus

uniprot Q99MA1 385
type: UnificationXref
id: Q99MA1
db: uniprot

uniprot V5IKE7 883
type: UnificationXref
id: V5IKE7
db: uniprot

Ras family GTPase
type: ProteinReference
xref: uniprot Q24806 271
organism: Entamoeba histolytica

uniprot P17491 596
type: UnificationXref
id: P17491
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F7AU53 83
xref: PTHR23255:SF63
organism: Monodelphis domestica

uniprot Q66HX9 823
type: UnificationXref
id: Q66HX9
db: uniprot

uniprot P0CP94 728
type: UnificationXref
id: P0CP94
db: uniprot

uniprot F0ZI47 224
type: UnificationXref
id: F0ZI47
db: uniprot

uniprot Q9V3Q6 445
type: UnificationXref
id: Q9V3Q6
db: uniprot

Forkhead box protein H1
type: ProteinReference
xref: uniprot O88621 348
xref: PTHR47316:SF1
organism: Mus musculus

uniprot H2QWX3 340
type: UnificationXref
id: H2QWX3
db: uniprot

uniprot Q8WQG9 426
type: UnificationXref
id: Q8WQG9
db: uniprot

uniprot A0A1D5QUZ8 838
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7C798 22
xref: PTHR24055:SF109
organism: Macaca mulatta

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot O42124 96
xref: PTHR23255:SF63
organism: Gallus gallus

Transforming growth factor beta
type: ProteinReference
xref: PTHR11848:SF141
xref: uniprot H2Q153 538
organism: Pan troglodytes

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F7A9B7 196
xref: PTHR11254:SF300
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR17045:SF6
xref: uniprot F7FG01 333
organism: Macaca mulatta

uniprot H2Q572 337
type: UnificationXref
id: H2Q572
db: uniprot

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: uniprot F6ZWJ7 707
xref: PTHR15505:SF1
organism: Macaca mulatta

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot F6R871 82
xref: PTHR23255:SF64
organism: Xenopus tropicalis

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot F7EG01 86
xref: PTHR23255:SF64
organism: Monodelphis domestica

UNC-129
type: ProteinReference
xref: uniprot G5EBY8 534
xref: PTHR11848:SF4
organism: Caenorhabditis elegans

uniprot W4XBC2 705
type: UnificationXref
id: W4XBC2
db: uniprot

uniprot P70618 37
type: UnificationXref
id: P70618
db: uniprot

TGF-beta receptor type-1
type: ProteinReference
xref: uniprot Q64729 178
xref: PTHR23255:SF61
organism: Mus musculus

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot O77627 347
organism: Bos taurus

Complex (Co-Smads/RSmads)
type: Complex
component stoichiometry: Co Smads s5 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: RSmads s6 sa7 STOICHIOMETRY ID COMPLEX
component: Co-Smads
component: RSmads
feature: COMPLEX BINDING FEATURE s48 a57 890
feature: COMPLEX BINDING FEATURE s48 a57 888
cellular location: nucleus

ncbitaxon 39947 863
type: UnificationXref
id: 39947
db: ncbitaxon

Mothers against decapentaplegic homolog 2
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot Q9I9P9 831
organism: Danio rerio

uniprot F1NCI7 75
type: UnificationXref
id: F1NCI7
db: uniprot

uniprot G3X793 23
type: UnificationXref
id: G3X793
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 806
xref: uniprot O96660 805
xref: PTHR13703:SF25
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TAK-RIGHT__TAK-_r22
controller: Complex (TGFbetareceptor I/TGFbetareceptor II/ TGF_beta)

uniprot P43029 621
type: UnificationXref
id: P43029
db: uniprot

Ras-related protein R-Ras
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot P10301 257
organism: Homo sapiens

Transcription factor jun-B
type: ProteinReference
xref: uniprot P24898 365
xref: PTHR11462:SF37
organism: Rattus norvegicus

uniprot O15105 765
type: UnificationXref
id: O15105
db: uniprot

uniprot A0A1D5PGR5 448
type: UnificationXref
id: A0A1D5PGR5
db: uniprot

uniprot F7A479 513
type: UnificationXref
id: F7A479
db: uniprot

uniprot F1PY87 321
type: UnificationXref
id: F1PY87
db: uniprot

Mothers against decapentaplegic homolog 6
type: ProteinReference
xref: PTHR13703:SF28
xref: uniprot O35182 766
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E4H6 521
xref: PTHR11848:SF137
organism: Macaca mulatta

uniprot O70436 804
type: UnificationXref
id: O70436
db: uniprot

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot Q7PVA5 748
organism: Anopheles gambiae

uniprot P08647 253
type: UnificationXref
id: P08647
db: uniprot

Bone morphogenetic protein 7, gene 1
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot F7APG6 515
organism: Xenopus tropicalis

uniprot E1BMX0 218
type: UnificationXref
id: E1BMX0
db: uniprot

I-SMAD
type: DnaRegionReference
member entity reference: Mothers against decapentaplegic homolog 6
member entity reference: Mothers against decapentaplegic homolog
member entity reference: Mothers against decapentaplegic homolog 7
xref: G01548
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.GENE.GENE.I-SMAD
comment: ENTITY_REFERENCE_NOTES=

TGFbetareceptors
type: Protein
entity reference: TGFbetareceptors
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
type: ProteinReference
xref: uniprot Q15750 776
xref: PTHR13832:SF533
organism: Homo sapiens

TGF-beta signaling pathway
type: Pathway
pathway component: TRANSCRIPTION_LEFT__I_SMAD-RIGHT__I_SMAD-_re26
pathway component: STATE_TRANSITION_LEFT__TAK-RIGHT__TAK-_r22
pathway component: STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r26
pathway component: STATE_TRANSITION_LEFT__Complex__Smurfs_RSmads_-RIGHT__a92_degraded-_r32
pathway component: STATE_TRANSITION_LEFT__Ras_GDP-RIGHT__Ras_GTP-_r18
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__RSmads-RIGHT__RSmads-_r10
pathway component: HETERODIMER_ASSOCIATION_LEFT__Co_Smads-_RSmads-RIGHT__Complex__Co_Smads_RSmads_-_r12
pathway component: STATE_TRANSITION_LEFT__P38-RIGHT__P38-_r25
pathway component: HETERODIMER_ASSOCIATION_LEFT__Smurfs-_RSmads-RIGHT__Complex__Smurfs_RSmads_-_r31
pathway component: TRANSLATION_LEFT__I_SMAD-RIGHT__I_Smads-_re27
pathway component: HETERODIMER_ASSOCIATION_LEFT__TGFbetareceptors-_TGFbeta-RIGHT__Complex__TGFbetareceptor_I_TGFbetareceptor_II__TGF_beta_-_r9
pathway component: STATE_TRANSITION_LEFT__p42_p44MAPKs-RIGHT__p42_p44MAPKs-_r21
pathway component: TRANSPORT_LEFT__Complex__Co_Smads_RSmads_-RIGHT__Complex__Co_Smads_RSmads_-_r13
pathway component: HETERODIMER_ASSOCIATION_LEFT__TAK-_TAB-RIGHT__Complex__TAK_TAB_-_r24
pathway component: HETERODIMER_ASSOCIATION_LEFT__Co_activators_corepressors-_Complex__Co_Smads_RSmads_-RIGHT__Complex__Co_activators_corepressors_Co_Smads__RSmads_-_r14
xref: PANTHER Pathway P00052 1
comment: MODEL_NOTES=Panther Pathway: P00052 PMID: 11586292 PMID: 9759503

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 47

uniprot O15264 28
type: UnificationXref
id: O15264
db: uniprot

uniprot F7H8X1 775
type: UnificationXref
id: F7H8X1
db: uniprot

Transforming growth factor beta
type: ProteinReference
xref: uniprot H2QGE0 548
xref: PTHR11848:SF125
organism: Pan troglodytes

ncbitaxon 9544 19
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot P18331 598
type: UnificationXref
id: P18331
db: uniprot

uniprot Q6HA10 662
type: UnificationXref
id: Q6HA10
db: uniprot

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q15759 39
organism: Homo sapiens

Bone morphogenetic protein 7
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot G3V6W8 533
organism: Rattus norvegicus

uniprot Q92793 382
type: UnificationXref
id: Q92793
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r26
controller: Complex (TAK/TAB)

uniprot B0S7E0 459
type: UnificationXref
id: B0S7E0
db: uniprot

uniprot F7CCD5 437
type: UnificationXref
id: F7CCD5
db: uniprot

Derriere protein
type: ProteinReference
xref: uniprot Q66KL4 659
xref: PTHR11848:SF259
organism: Xenopus tropicalis

Bone morphogenetic protein 10
type: ProteinReference
xref: PTHR11848:SF39
xref: uniprot Q9R229 687
organism: Mus musculus

uniprot Q62432 822
type: UnificationXref
id: Q62432
db: uniprot

uniprot Q9Z0J7 699
type: UnificationXref
id: Q9Z0J7
db: uniprot

P38
type: Protein
entity reference: P38
feature: P38 s63 a72 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: uniprot Q9DFZ0 717
xref: PTHR15505:SF1
organism: Danio rerio

uniprot F1QKF4 80
type: UnificationXref
id: F1QKF4
db: uniprot

Mothers against decapentaplegic homolog
type: DnaReference
xref: PTHR13703:SF28
organism: Rattus norvegicus

Peptidyl-prolyl cis-trans isomerase
type: ProteinReference
xref: uniprot Q8F361 749
organism: Leptospira interrogans

uniprot P01120 247
type: UnificationXref
id: P01120
db: uniprot

uniprot Q5Z859 871
type: UnificationXref
id: Q5Z859
db: uniprot

Growth/differentiation factor 8
type: ProteinReference
xref: PTHR11848:SF150
xref: uniprot O14793 567
organism: Homo sapiens

uniprot Q9WUK5 694
type: UnificationXref
id: Q9WUK5
db: uniprot

uniprot P49001 622
type: UnificationXref
id: P49001
db: uniprot

uniprot F1P0N0 317
type: UnificationXref
id: F1P0N0
db: uniprot

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F1PQT6 192
xref: PTHR11254:SF293
organism: Canis lupus familiaris

Mothers against decapentaplegic homolog 5
type: ProteinReference
xref: PTHR13703:SF36
xref: uniprot P97454 813
organism: Mus musculus

Bone morphogenetic protein 15
type: ProteinReference
xref: PTHR11848:SF22
xref: uniprot H2QYM3 559
organism: Pan troglodytes

RAS related
type: ProteinReference
xref: uniprot E2R5G6 219
xref: PTHR24070:SF245
organism: Canis lupus familiaris

uniprot F7C435 516
type: UnificationXref
id: F7C435
db: uniprot

uniprot F6Q1B1 81
type: UnificationXref
id: F6Q1B1
db: uniprot

Serine/threonine-protein kinase receptor R3
type: ProteinReference
xref: PTHR23255:SF66
xref: uniprot P37023 164
organism: Homo sapiens

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot O15264 28
organism: Homo sapiens

uniprot H2Q215 540
type: UnificationXref
id: H2Q215
db: uniprot

PTHR10516:SF301
type: RelationshipXref
id: PTHR10516:SF301
db: PANTHER Family
relationship type: By Homology

uniprot Q12526 269
type: UnificationXref
id: Q12526
db: uniprot

ACTIVE 54
type: EntityFeature
comment: Active state

uniprot P23359 606
type: UnificationXref
id: P23359
db: uniprot

PARTICIPANT STOICHIOMETRY r18 922
type: Stoichiometry
physical entity: Ras-GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 921
type: Stoichiometry
physical entity: Ras-GDP
stoichiometric coefficient: 1.0

uniprot Q9W1H5 395
type: UnificationXref
id: Q9W1H5
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot M9PE88 94
xref: PTHR23255:SF63
organism: Drosophila melanogaster

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF45
xref: uniprot A0A1D5QTT6 55
organism: Macaca mulatta

PTHR23351:SF6
type: RelationshipXref
id: PTHR23351:SF6
db: PANTHER Family
relationship type: By Homology

uniprot O08689 565
type: UnificationXref
id: O08689
db: uniprot

Complex (Smurfs/RSmads)
type: Complex
component stoichiometry: RSmads s11 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smurfs s10 sa13 STOICHIOMETRY ID COMPLEX
component: Smurfs
component: RSmads
feature: COMPLEX BINDING FEATURE s76 a92 892
feature: COMPLEX BINDING FEATURE s76 a92 894
cellular location: cytosol

uniprot F1QXZ9 787
type: UnificationXref
id: F1QXZ9
db: uniprot

mRNA-decapping enzyme 1A
type: ProteinReference
xref: uniprot Q91YD3 381
xref: PTHR16290:SF4
organism: Mus musculus

uniprot P10158 353
type: UnificationXref
id: P10158
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q04970 268
xref: PTHR24070:SF189
organism: Rattus norvegicus

FK506-binding protein 1
type: ProteinReference
xref: uniprot P0CP94 728
organism: Cryptococcus neoformans

Ras-like protein rasD
type: ProteinReference
xref: PTHR24070:SF418
xref: uniprot P03967 248
organism: Dictyostelium discoideum

ncbitaxon 9913 5
type: UnificationXref
id: 9913
db: ncbitaxon

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9LMM5 880
organism: Arabidopsis thaliana

uniprot P55105 630
type: UnificationXref
id: P55105
db: uniprot

uniprot E1BNB5 308
type: UnificationXref
id: E1BNB5
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F6TU68 789
xref: PTHR13703:SF23
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7B5L8 412
xref: PTHR24055:SF172
organism: Ornithorhynchus anatinus

Transforming growth factor beta-1 proprotein
type: ProteinReference
xref: uniprot P54831 627
xref: PTHR11848:SF125
organism: Canis lupus familiaris

uniprot F1PNA9 79
type: UnificationXref
id: F1PNA9
db: uniprot

uniprot G3MZV8 90
type: UnificationXref
id: G3MZV8
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF62
xref: uniprot F1NTD3 135
organism: Gallus gallus

Growth/differentiation factor 8
type: ProteinReference
xref: uniprot A1C2U6 455
xref: PTHR11848:SF150
organism: Macaca mulatta

uniprot P45878 734
type: UnificationXref
id: P45878
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QLH3 433
xref: PTHR47140:SF1
organism: Macaca mulatta

uniprot Q63844 872
type: UnificationXref
id: Q63844
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot Q1RLX1 174
xref: PTHR23255:SF50
organism: Danio rerio

FK506-binding protein 1
type: ProteinReference
xref: uniprot P20081 731
organism: Saccharomyces cerevisiae

FK506-binding protein 1A
type: ProteinReference
xref: uniprot P20080 730
organism: Neurospora crassa

uniprot O43897 573
type: UnificationXref
id: O43897
db: uniprot

Mothers against decapentaplegic homolog 4
type: ProteinReference
xref: uniprot P97471 66
xref: PTHR13703:SF45
organism: Mus musculus

Transcription factor AP-1
type: ProteinReference
xref: uniprot P18289 363
xref: PTHR11462:SF35
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N4I7 315
organism: Bos taurus

uniprot F6ZGX8 232
type: UnificationXref
id: F6ZGX8
db: uniprot

Evidence 806
type: Evidence
evidence code: TAS
comment: Website http://flybase.org/reports/FBrf0190369.html

uniprot H2QIU8 154
type: UnificationXref
id: H2QIU8
db: uniprot

uniprot H2R0G7 416
type: UnificationXref
id: H2R0G7
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 19

uniprot Q9JIW5 832
type: UnificationXref
id: Q9JIW5
db: uniprot

Activin beta-C chain
type: ProteinReference
xref: uniprot F7H9S4 527
xref: PTHR11848:SF130
organism: Macaca mulatta

uniprot O02812 24
type: UnificationXref
id: O02812
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F7E905 330
organism: Monodelphis domestica

uniprot Q9LMM5 880
type: UnificationXref
id: Q9LMM5
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot Q0IHM5 173
xref: PTHR23255:SF62
organism: Xenopus tropicalis

PTHR24070:SF418
type: RelationshipXref
id: PTHR24070:SF418
db: PANTHER Family
relationship type: By Homology

uniprot F6Y0Z8 792
type: UnificationXref
id: F6Y0Z8
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05627 351
organism: Mus musculus

Embryonic growth/differentiation factor 1
type: ProteinReference
xref: PTHR11848:SF151
xref: uniprot P20863 600
organism: Mus musculus

uniprot Q04771 171
type: UnificationXref
id: Q04771
db: uniprot

uniprot P17535 362
type: UnificationXref
id: P17535
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q9DGD9 428
xref: PTHR24055:SF222
organism: Danio rerio

Zinc metalloproteinase nas-39
type: ProteinReference
xref: PTHR45645:SF29
xref: uniprot Q20176 651
organism: Caenorhabditis elegans

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF41
xref: uniprot E2R326 784
organism: Canis lupus familiaris

PTHR11848:SF257
type: RelationshipXref
id: PTHR11848:SF257
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF259
type: RelationshipXref
id: PTHR11848:SF259
db: PANTHER Family
relationship type: By Homology

uniprot P39745 859
type: UnificationXref
id: P39745
db: uniprot

ncbitaxon 9606 29
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q6GQM7 714
type: UnificationXref
id: Q6GQM7
db: uniprot

Left-right determination factor
type: ProteinReference
xref: PTHR11848:SF226
xref: uniprot Q9W6I6 693
organism: Danio rerio

uniprot D3ZGK9 464
type: UnificationXref
id: D3ZGK9
db: uniprot

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: uniprot Q9DGE1 48
xref: PTHR24055:SF110
organism: Danio rerio

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: uniprot Q9DGE2 49
xref: PTHR24055:SF110
organism: Danio rerio

uniprot M9PE88 94
type: UnificationXref
id: M9PE88
db: uniprot

uniprot F1QWZ9 494
type: UnificationXref
id: F1QWZ9
db: uniprot

STATE_TRANSITION_LEFT__Ras_GDP-RIGHT__Ras_GTP-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 921
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 922
left: Ras-GDP
interaction type: STATE_TRANSITION
right: Ras-GTP

uniprot Q60665 373
type: UnificationXref
id: Q60665
db: uniprot

PTHR24070:SF420
type: RelationshipXref
id: PTHR24070:SF420
db: PANTHER Family
relationship type: By Homology

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

JunB proto-oncogene, AP-1 transcription factor subunit b
type: ProteinReference
xref: PTHR11462:SF37
xref: uniprot A0A0R4IAV4 296
organism: Danio rerio

uniprot P43021 617
type: UnificationXref
id: P43021
db: uniprot

uniprot P21274 602
type: UnificationXref
id: P21274
db: uniprot

uniprot P12755 354
type: UnificationXref
id: P12755
db: uniprot

PTHR11848:SF264
type: RelationshipXref
id: PTHR11848:SF264
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF263
type: RelationshipXref
id: PTHR11848:SF263
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF262
type: RelationshipXref
id: PTHR11848:SF262
db: PANTHER Family
relationship type: By Homology

uniprot Q15750 776
type: UnificationXref
id: Q15750
db: uniprot

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot E2R9R5 720
organism: Canis lupus familiaris

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF58
xref: uniprot F6S9J1 141
organism: Macaca mulatta

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF22
xref: uniprot F7HNS7 150
organism: Macaca mulatta

uniprot O73736 158
type: UnificationXref
id: O73736
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
evidence: Evidence 125
evidence: Evidence 126
xref: uniprot A1Z7L8 124
xref: PTHR23255:SF71
organism: Drosophila melanogaster

BMP4
type: ProteinReference
xref: uniprot Q90YD6 676
xref: PTHR11848:SF165
organism: Xenopus tropicalis

Activin receptor type-1C
type: ProteinReference
xref: uniprot P70539 166
xref: PTHR23255:SF58
organism: Rattus norvegicus

BMP-2
type: ProteinReference
xref: uniprot Q90YD7 677
xref: PTHR11848:SF143
organism: Xenopus tropicalis

Metalloendopeptidase
type: ProteinReference
xref: PTHR45645:SF15
xref: uniprot A0A2I3SUG7 452
organism: Pan troglodytes

STATE_TRANSITION
type: RelationshipTypeVocabulary

PTHR11848:SF232
type: RelationshipXref
id: PTHR11848:SF232
db: PANTHER Family
relationship type: By Homology

uniprot F6S0Q9 788
type: UnificationXref
id: F6S0Q9
db: uniprot

uniprot K7DK66 242
type: UnificationXref
id: K7DK66
db: uniprot

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 879

Bone morphogenetic protein 3
type: ProteinReference
xref: uniprot H2QPS3 553
xref: PTHR11848:SF144
organism: Pan troglodytes

uniprot F1PPK6 137
type: UnificationXref
id: F1PPK6
db: uniprot

uniprot Q6PBJ8 743
type: UnificationXref
id: Q6PBJ8
db: uniprot

FOS like 1, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR23351:SF6
xref: uniprot E2REG1 311
organism: Canis lupus familiaris

AGAP002219-PA
type: ProteinReference
xref: uniprot Q7QK91 281
xref: PTHR24070:SF420
organism: Anopheles gambiae

Bone morphogenetic protein 5
type: ProteinReference
xref: PTHR11848:SF139
xref: uniprot E2RNJ0 476
organism: Canis lupus familiaris

PTHR11848:SF241
type: RelationshipXref
id: PTHR11848:SF241
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF242
type: RelationshipXref
id: PTHR11848:SF242
db: PANTHER Family
relationship type: By Homology

uniprot Q8QGE3 673
type: UnificationXref
id: Q8QGE3
db: uniprot

uniprot Q9C5X9 387
type: UnificationXref
id: Q9C5X9
db: uniprot

BMP7 isoform 2
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot H2QKM7 552
organism: Pan troglodytes

Peptidyl-prolyl cis-trans isomerase FKBP1B
type: ProteinReference
xref: uniprot P68106 737
organism: Homo sapiens

Peptidyl-prolyl cis-trans isomerase FKBP1B
type: ProteinReference
xref: uniprot P68107 738
organism: Bos taurus

uniprot E2RNJ0 476
type: UnificationXref
id: E2RNJ0
db: uniprot

p42/p44MAPKs
type: Protein
entity reference: p42/p44MAPKs
feature: p42 p44MAPKs s66 a69 rs1
feature: ACTIVE 54
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: PTHR15505:SF1
xref: uniprot J9NW61 709
organism: Canis lupus familiaris

Mitogen-activated protein kinase mpk-1
type: ProteinReference
xref: uniprot P39745 859
organism: Caenorhabditis elegans

Histone acetyltransferase HAC5
type: ProteinReference
xref: PTHR13808:SF30
xref: uniprot Q9LE42 393
organism: Arabidopsis thaliana

uniprot F7E4H6 521
type: UnificationXref
id: F7E4H6
db: uniprot

Co Smads s5 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Co-Smads
stoichiometric coefficient: 1.0

uniprot Q28EW2 273
type: UnificationXref
id: Q28EW2
db: uniprot

uniprot P36896 161
type: UnificationXref
id: P36896
db: uniprot

uniprot P15336 357
type: UnificationXref
id: P15336
db: uniprot

uniprot A8WS81 781
type: UnificationXref
id: A8WS81
db: uniprot

P38 s70 a81 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 10

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 42

Decapping mRNA 1B
type: ProteinReference
xref: uniprot H2Q572 337
organism: Pan troglodytes

uniprot A0A0R4IZE5 447
type: UnificationXref
id: A0A0R4IZE5
db: uniprot

uniprot Q9NR23 684
type: UnificationXref
id: Q9NR23
db: uniprot

uniprot P08642 251
type: UnificationXref
id: P08642
db: uniprot

Pristionchus pacificus
type: BioSource
xref: ncbitaxon 54126 239

uniprot H2QR58 288
type: UnificationXref
id: H2QR58
db: uniprot

uniprot F7AU53 83
type: UnificationXref
id: F7AU53
db: uniprot

Inhibin beta chain
type: ProteinReference
xref: uniprot O61643 576
xref: PTHR11848:SF178
organism: Drosophila melanogaster

uniprot F6S0Q2 500
type: UnificationXref
id: F6S0Q2
db: uniprot

uniprot E2RP23 786
type: UnificationXref
id: E2RP23
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O08911 26
organism: Mus musculus

uniprot P80204 170
type: UnificationXref
id: P80204
db: uniprot

uniprot F6QUF3 498
type: UnificationXref
id: F6QUF3
db: uniprot

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

uniprot O35182 766
type: UnificationXref
id: O35182
db: uniprot

p42 p44MAPKs s66 a69 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.7469590936560997
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot F1NFN4 190
type: UnificationXref
id: F1NFN4
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot D4A3U7 11
xref: PTHR24055:SF109
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 842
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r22 913
type: Stoichiometry
physical entity: TAK
stoichiometric coefficient: 1.0

PTHR11848:SF228
type: RelationshipXref
id: PTHR11848:SF228
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r22 912
type: Stoichiometry
physical entity: TAK
stoichiometric coefficient: 1.0

uniprot G5EBK8 236
type: UnificationXref
id: G5EBK8
db: uniprot

PTHR11848:SF226
type: RelationshipXref
id: PTHR11848:SF226
db: PANTHER Family
relationship type: By Homology

INHBA isoform 1
type: ProteinReference
xref: PTHR11848:SF133
xref: uniprot H2QUH0 557
organism: Pan troglodytes

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF22
xref: uniprot F1MSQ2 134
organism: Bos taurus

STATE_TRANSITION_LEFT__Complex__Smurfs_RSmads_-RIGHT__a92_degraded-_r32
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 917
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 916
left: Complex (Smurfs/RSmads)
interaction type: STATE_TRANSITION
right: a92_degraded

RSmads s39 a44 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11254:SF395
type: RelationshipXref
id: PTHR11254:SF395
db: PANTHER Family
relationship type: By Homology

PTHR23255:SF22
type: RelationshipXref
id: PTHR23255:SF22
db: PANTHER Family
relationship type: By Homology

Peptidyl-prolyl cis-trans isomerase FKBP1A
type: ProteinReference
xref: uniprot P18203 729
organism: Bos taurus

uniprot Q8MXI4 45
type: UnificationXref
id: Q8MXI4
db: uniprot

ncbitaxon 5786 223
type: UnificationXref
id: 5786
db: ncbitaxon

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 256

FHA domain-containing protein DDL
type: ProteinReference
xref: uniprot Q8W4D8 378
organism: Arabidopsis thaliana

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot H2QQ88 800
organism: Pan troglodytes

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot H2QPW8 155
xref: PTHR23255:SF62
organism: Pan troglodytes

Metalloendopeptidase
type: ProteinReference
xref: PTHR45645:SF15
xref: uniprot F7CEL9 518
organism: Macaca mulatta

uniprot Q9LQQ9 881
type: UnificationXref
id: Q9LQQ9
db: uniprot

uniprot E1AWU3 706
type: UnificationXref
id: E1AWU3
db: uniprot

GTP binding protein
type: ProteinReference
xref: uniprot G5EBK8 236
organism: Caenorhabditis elegans

uniprot F6Y4G8 410
type: UnificationXref
id: F6Y4G8
db: uniprot

TGF-beta receptor type-2
type: ProteinReference
xref: uniprot F1QKF4 80
xref: PTHR23255:SF55
organism: Danio rerio

uniprot Q9I8K7 391
type: UnificationXref
id: Q9I8K7
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Co_Smads-_RSmads-RIGHT__Complex__Co_Smads_RSmads_-_r12
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 933
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 932
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 931
left: RSmads
left: Co-Smads
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Co-Smads/RSmads)

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot C8V7D1 840
organism: Emericella nidulans

uniprot P84022 810
type: UnificationXref
id: P84022
db: uniprot

uniprot Q9Z0J6 698
type: UnificationXref
id: Q9Z0J6
db: uniprot

Left-right determination factor
type: ProteinReference
xref: PTHR11848:SF226
xref: uniprot F1QWZ9 494
organism: Danio rerio

Growth/differentiation factor 6
type: ProteinReference
xref: PTHR11848:SF43
xref: uniprot A0A452DKC3 454
organism: Bos taurus

uniprot P12645 592
type: UnificationXref
id: P12645
db: uniprot

Co-Smads
type: Protein
entity reference: Co-Smads
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q39022 865
type: UnificationXref
id: Q39022
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 462

uniprot P17325 361
type: UnificationXref
id: P17325
db: uniprot

Growth differentiation factor 5
type: ProteinReference
xref: uniprot F1MT44 483
xref: PTHR11848:SF44
organism: Bos taurus

uniprot P18075 597
type: UnificationXref
id: P18075
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 418
xref: PTHR24055:SF222
organism: Homo sapiens

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P45984 419
xref: PTHR24055:SF172
organism: Homo sapiens

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot F7EP21 724
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r13 930
type: Stoichiometry
physical entity: Complex (Co-Smads/RSmads)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1B8D6 306
xref: PTHR13808:SF29
organism: Bos taurus

ncbitaxon 367110 261
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot F1QH44 139
type: UnificationXref
id: F1QH44
db: uniprot

GDF3 isoform 1
type: ProteinReference
xref: PTHR11848:SF38
xref: uniprot H2Q5C7 541
organism: Pan troglodytes

RSmads s9 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RSmads
stoichiometric coefficient: 1.0

uniprot F1Q1E2 322
type: UnificationXref
id: F1Q1E2
db: uniprot

uniprot A0A2I3TGY5 184
type: UnificationXref
id: A0A2I3TGY5
db: uniprot

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3SEI4 451
type: UnificationXref
id: A0A2I3SEI4
db: uniprot

Mothers against decapentaplegic homolog 4
type: ProteinReference
xref: PTHR13703:SF45
xref: uniprot Q13485 67
organism: Homo sapiens

uniprot O62609 63
type: UnificationXref
id: O62609
db: uniprot

PARTICIPANT STOICHIOMETRY r25 939
type: Stoichiometry
physical entity: P38
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 938
type: Stoichiometry
physical entity: P38
stoichiometric coefficient: 1.0

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot F6XMD4 722
organism: Macaca mulatta

uniprot E2R889 474
type: UnificationXref
id: E2R889
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q9M1Z5 882
organism: Arabidopsis thaliana

RSmads s39 a44 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.04441521524691084
comment: MODIFICATION_RESIDUE_NAME=

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot Q92793 382
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r13 929
type: Stoichiometry
physical entity: Complex (Co-Smads/RSmads)
stoichiometric coefficient: 1.0

P01277
type: UnificationXref
id: P01277
db: PANTHER Pathway Component

P01276
type: UnificationXref
id: P01276
db: PANTHER Pathway Component

Histone acetyltransferase HAC2
type: ProteinReference
xref: PTHR13808:SF43
xref: uniprot Q9FYH1 390
organism: Arabidopsis thaliana

uniprot Q9DER7 682
type: UnificationXref
id: Q9DER7
db: uniprot

P01279
type: UnificationXref
id: P01279
db: PANTHER Pathway Component

P01278
type: UnificationXref
id: P01278
db: PANTHER Pathway Component

uniprot F6UAA8 790
type: UnificationXref
id: F6UAA8
db: uniprot

uniprot F1R5Z7 496
type: UnificationXref
id: F1R5Z7
db: uniprot

uniprot Q78EA7 179
type: UnificationXref
id: Q78EA7
db: uniprot

P01275
type: UnificationXref
id: P01275
db: PANTHER Pathway Component

PTHR23255:SF64
type: RelationshipXref
id: PTHR23255:SF64
db: PANTHER Family
relationship type: By Homology

GTPase HRas
type: ProteinReference
xref: uniprot Q61411 280
xref: PTHR24070:SF385
organism: Mus musculus

uniprot A0A3Q1LJZ7 4
type: UnificationXref
id: A0A3Q1LJZ7
db: uniprot

PTHR23255:SF62
type: RelationshipXref
id: PTHR23255:SF62
db: PANTHER Family
relationship type: By Homology

GTPase NRas
type: ProteinReference
xref: uniprot P08556 250
xref: PTHR24070:SF189
organism: Mus musculus

PTHR23255:SF63
type: RelationshipXref
id: PTHR23255:SF63
db: PANTHER Family
relationship type: By Homology

PTHR23255:SF68
type: RelationshipXref
id: PTHR23255:SF68
db: PANTHER Family
relationship type: By Homology

PTHR23255:SF69
type: RelationshipXref
id: PTHR23255:SF69
db: PANTHER Family
relationship type: By Homology

PTHR23255:SF66
type: RelationshipXref
id: PTHR23255:SF66
db: PANTHER Family
relationship type: By Homology

uniprot H2Q183 539
type: UnificationXref
id: H2Q183
db: uniprot

TRANSCRIPTION
type: InteractionVocabulary

uniprot Q09488 106
type: UnificationXref
id: Q09488
db: uniprot

uniprot Q5F352 279
type: UnificationXref
id: Q5F352
db: uniprot

AGAP004049-PA
type: ProteinReference
xref: PTHR46319:SF3
xref: uniprot Q7QH71 292
organism: Anopheles gambiae

uniprot F6SV95 143
type: UnificationXref
id: F6SV95
db: uniprot

RE68879p
type: ProteinReference
xref: uniprot Q9W5Q1 396
organism: Drosophila melanogaster

uniprot C8V7D1 840
type: UnificationXref
id: C8V7D1
db: uniprot

uniprot E2RSB0 15
type: UnificationXref
id: E2RSB0
db: uniprot

PTHR11848:SF6
type: RelationshipXref
id: PTHR11848:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q84UI5 877
type: UnificationXref
id: Q84UI5
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot D3ZAQ2 757
xref: PTHR13703:SF28
organism: Rattus norvegicus

PTHR23255:SF72
type: RelationshipXref
id: PTHR23255:SF72
db: PANTHER Family
relationship type: By Homology

PTHR23255:SF71
type: RelationshipXref
id: PTHR23255:SF71
db: PANTHER Family
relationship type: By Homology

PTHR23255:SF70
type: RelationshipXref
id: PTHR23255:SF70
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF4
type: RelationshipXref
id: PTHR11848:SF4
db: PANTHER Family
relationship type: By Homology

Ceramide synthase 1
type: ProteinReference
xref: PTHR11848:SF242
xref: uniprot Q1HL14 650
organism: Rattus norvegicus

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot Q6DIS7 824
organism: Xenopus tropicalis

GDF15 isoform 1
type: ProteinReference
xref: PTHR11848:SF78
xref: uniprot H2QFT1 547
organism: Pan troglodytes

PTHR23255:SF55
type: RelationshipXref
id: PTHR23255:SF55
db: PANTHER Family
relationship type: By Homology

Bone morphogenetic protein 1
type: ProteinReference
xref: uniprot P13497 593
xref: PTHR45645:SF24
organism: Homo sapiens

Anti-Muellerian hormone type-2 receptor
type: ProteinReference
xref: uniprot Q8K592 114
xref: PTHR23255:SF49
organism: Mus musculus

PTHR23255:SF58
type: RelationshipXref
id: PTHR23255:SF58
db: PANTHER Family
relationship type: By Homology

uniprot B3DI86 460
type: UnificationXref
id: B3DI86
db: uniprot

uniprot P20081 731
type: UnificationXref
id: P20081
db: uniprot

Growth/differentiation factor 2
type: ProteinReference
xref: uniprot Q9WV56 695
xref: PTHR11848:SF157
organism: Mus musculus

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F7H249 88
xref: PTHR23255:SF63
organism: Macaca mulatta

STATE_TRANSITION_LEFT__P38-RIGHT__P38-_r25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 939
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 938
left: P38
interaction type: STATE_TRANSITION
right: P38

Mitogen-activated protein kinase spk1
type: ProteinReference
xref: uniprot P27638 857
organism: Schizosaccharomyces pombe

Dwarfin sma (Fragment)
type: ProteinReference
xref: uniprot A8X3D3 782
xref: PTHR13703:SF61
organism: Caenorhabditis briggsae

Metalloendopeptidase
type: ProteinReference
xref: PTHR45645:SF26
xref: uniprot F1Q3H3 491
organism: Canis lupus familiaris

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 750

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8WRD7 9
xref: PTHR24055:SF238
organism: Caenorhabditis briggsae

uniprot E9I1I7 220
type: UnificationXref
id: E9I1I7
db: uniprot

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 754

uniprot Q7PVA5 748
type: UnificationXref
id: Q7PVA5
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: PTHR23255:SF70
xref: uniprot A0A1D5R6G4 72
organism: Macaca mulatta

uniprot F7H4T8 147
type: UnificationXref
id: F7H4T8
db: uniprot

PTHR23255:SF61
type: RelationshipXref
id: PTHR23255:SF61
db: PANTHER Family
relationship type: By Homology

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot E1BE92 783
organism: Bos taurus

PTHR11848:SF181
type: RelationshipXref
id: PTHR11848:SF181
db: PANTHER Family
relationship type: By Homology

uniprot F1PHV7 229
type: UnificationXref
id: F1PHV7
db: uniprot

uniprot P98063 639
type: UnificationXref
id: P98063
db: uniprot

uniprot O42222 572
type: UnificationXref
id: O42222
db: uniprot

uniprot Q9W6I6 693
type: UnificationXref
id: Q9W6I6
db: uniprot

uniprot F7CFQ6 796
type: UnificationXref
id: F7CFQ6
db: uniprot

uniprot F7BRY9 85
type: UnificationXref
id: F7BRY9
db: uniprot

uniprot Q7PZI7 668
type: UnificationXref
id: Q7PZI7
db: uniprot

PTHR23255:SF49
type: RelationshipXref
id: PTHR23255:SF49
db: PANTHER Family
relationship type: By Homology

uniprot O42124 96
type: UnificationXref
id: O42124
db: uniprot

E3 ubiquitin-protein ligase SMURF1
type: ProteinReference
xref: uniprot Q9CUN6 201
xref: PTHR11254:SF293
organism: Mus musculus

a92_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

PTHR23255:SF50
type: RelationshipXref
id: PTHR23255:SF50
db: PANTHER Family
relationship type: By Homology

ncbitaxon 3702 379
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot P49186 420
type: UnificationXref
id: P49186
db: uniprot

JNK s64 a73 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11848:SF175
type: RelationshipXref
id: PTHR11848:SF175
db: PANTHER Family
relationship type: By Homology

Co-Smads
type: Protein
entity reference: Co-Smads
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa6 889
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot F7CCD5 437
organism: Monodelphis domestica

Protein CBR-CDC-42
type: ProteinReference
xref: uniprot A8XGW3 215
organism: Caenorhabditis briggsae

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__p42_p44MAPKs-RIGHT__p42_p44MAPKs-_r21
controller: Ras-GTP

uniprot Q15797 817
type: UnificationXref
id: Q15797
db: uniprot

uniprot P79996 423
type: UnificationXref
id: P79996
db: uniprot

BMP5
type: ProteinReference
xref: PTHR11848:SF139
xref: uniprot P87373 636
organism: Gallus gallus

Transcription factor jun-B
type: ProteinReference
xref: PTHR11462:SF37
xref: uniprot F6U5C5 327
organism: Macaca mulatta

Bone morphogenetic protein receptor type-2
type: ProteinReference
xref: uniprot Q13873 108
xref: PTHR23255:SF63
organism: Homo sapiens

uniprot H2Q5Y5 152
type: UnificationXref
id: H2Q5Y5
db: uniprot

Forkhead box protein H1
type: ProteinReference
xref: PTHR11829:SF340
xref: uniprot Q9I9E1 392
organism: Danio rerio

PTHR24055:SF238
type: RelationshipXref
id: PTHR24055:SF238
db: PANTHER Family
relationship type: By Homology

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1QH44 139
organism: Danio rerio

Growth differentiation factor 8, like
type: ProteinReference
xref: uniprot Q68IN2 660
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR11848:SF157
xref: uniprot F7HMW7 531
organism: Macaca mulatta

PTHR11848:SF178
type: RelationshipXref
id: PTHR11848:SF178
db: PANTHER Family
relationship type: By Homology

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF36
xref: uniprot F6YMS3 795
organism: Macaca mulatta

uniprot F0ZB76 222
type: UnificationXref
id: F0ZB76
db: uniprot

UNKNOWN_INHIBITION
type: RelationshipTypeVocabulary

MAP3K7 C-terminal-like protein
type: ProteinReference
xref: uniprot P57077 442
xref: PTHR47140:SF1
organism: Homo sapiens

TRANSPORT_LEFT__Complex__Co_Smads_RSmads_-RIGHT__Complex__Co_Smads_RSmads_-_r13
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 929
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 930
left: Complex (Co-Smads/RSmads)
interaction type: TRANSPORT
right: Complex (Co-Smads/RSmads)

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__I_SMAD-RIGHT__I_SMAD-_re26
control type: ACTIVATION
controller: JNK

uniprot F6Q8L1 140
type: UnificationXref
id: F6Q8L1
db: uniprot

TRANSCRIPTION_LEFT__I_SMAD-RIGHT__I_SMAD-_re26
type: TemplateReaction
product: I-SMAD
xref: TRANSCRIPTION
participant: I-SMAD
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot Q99988 681
type: UnificationXref
id: Q99988
db: uniprot

uniprot H2R545 200
type: UnificationXref
id: H2R545
db: uniprot

uniprot Q16539 40
type: UnificationXref
id: Q16539
db: uniprot

Peptidyl-prolyl cis-trans isomerase
type: ProteinReference
xref: uniprot O42993 727
organism: Schizosaccharomyces pombe

JunB proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot J9NRZ4 342
xref: PTHR11462:SF37
organism: Canis lupus familiaris

uniprot Q9YI02 397
type: UnificationXref
id: Q9YI02
db: uniprot

uniprot A1C2U6 455
type: UnificationXref
id: A1C2U6
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__TGFbetareceptors-_TGFbeta-RIGHT__Complex__TGFbetareceptor_I_TGFbetareceptor_II__TGF_beta_-_r9
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 924
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 923
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 925
left: TGFbeta
left: TGFbetareceptors
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TGFbetareceptor I/TGFbetareceptor II/ TGF_beta)

uniprot O15198 802
type: UnificationXref
id: O15198
db: uniprot

uniprot Q9XXC0 431
type: UnificationXref
id: Q9XXC0
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 860
organism: Mus musculus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63086 861
organism: Rattus norvegicus

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 771
xref: PTHR13703:SF54
xref: uniprot Q5U110 770
organism: Drosophila melanogaster

Bone morphogenetic protein 5
type: ProteinReference
xref: PTHR11848:SF139
xref: uniprot D4A7P9 468
organism: Rattus norvegicus

uniprot F1PCQ4 318
type: UnificationXref
id: F1PCQ4
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot P53778 36
xref: PTHR24055:SF146
organism: Homo sapiens

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P53779 422
xref: PTHR24055:SF162
organism: Homo sapiens

uniprot H2R6C6 341
type: UnificationXref
id: H2R6C6
db: uniprot

CREB-binding protein isoform a
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F6RRA8 323
organism: Macaca mulatta

uniprot H2QHI6 725
type: UnificationXref
id: H2QHI6
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot Q07105 644
type: UnificationXref
id: Q07105
db: uniprot

uniprot P68106 737
type: UnificationXref
id: P68106
db: uniprot

uniprot Q39024 867
type: UnificationXref
id: Q39024
db: uniprot

uniprot Q9N272 50
type: UnificationXref
id: Q9N272
db: uniprot

TGF-beta receptor type-2
type: ProteinReference
xref: PTHR23255:SF55
xref: uniprot A0A2I3SE58 73
organism: Pan troglodytes

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O23236 852
organism: Arabidopsis thaliana

uniprot F1PGG7 319
type: UnificationXref
id: F1PGG7
db: uniprot

uniprot E2RCX7 785
type: UnificationXref
id: E2RCX7
db: uniprot

PTHR11254:SF300
type: RelationshipXref
id: PTHR11254:SF300
db: PANTHER Family
relationship type: By Homology

Smad nuclear-interacting protein 1
type: ProteinReference
xref: PTHR23308:SF36
xref: uniprot F6VCH4 328
organism: Macaca mulatta

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F7EF57 197
xref: PTHR11254:SF300
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: uniprot Q7PVR1 875
organism: Anopheles gambiae

uniprot Q95126 117
type: UnificationXref
id: Q95126
db: uniprot

uniprot O61643 576
type: UnificationXref
id: O61643
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot A0A0B4K7J3 118
xref: PTHR23255:SF72
organism: Drosophila melanogaster

uniprot E2QW66 128
type: UnificationXref
id: E2QW66
db: uniprot

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot A0A2R8Q8S1 206
organism: Danio rerio

uniprot A0A2I3SE58 73
type: UnificationXref
id: A0A2I3SE58
db: uniprot

uniprot Q503B6 275
type: UnificationXref
id: Q503B6
db: uniprot

PTHR24070:SF17
type: RelationshipXref
id: PTHR24070:SF17
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LWJ8 402
xref: PTHR24055:SF222
organism: Bos taurus

Growth differentiation factor 9
type: ProteinReference
xref: uniprot Q6Q247 665
xref: PTHR11848:SF19
organism: Gallus gallus

uniprot O42993 727
type: UnificationXref
id: O42993
db: uniprot

uniprot Q7QE97 113
type: UnificationXref
id: Q7QE97
db: uniprot

uniprot Q24806 271
type: UnificationXref
id: Q24806
db: uniprot

uniprot E9PTU9 477
type: UnificationXref
id: E9PTU9
db: uniprot

uniprot F6T7D0 326
type: UnificationXref
id: F6T7D0
db: uniprot

uniprot F7HPH2 89
type: UnificationXref
id: F7HPH2
db: uniprot

TAB
type: Protein
entity reference: TAB
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa12 911
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TGFbeta
type: ProteinReference
xref: P01286
standard name: Transforming growth factor beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.TGF_beta
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Transforming growth factor beta
member entity reference: Uncharacterized protein
member entity reference: Dorsal-ventral patterning tolloid-like protein 1
member entity reference: Growth/differentiation factor 8
member entity reference: Growth/differentiation factor 3
member entity reference: Left-right determination factor 2
member entity reference: Left-right determination factor 1
member entity reference: Left-right determination factor
member entity reference: Dorsalin-1
member entity reference: Bone morphogenetic protein 4
member entity reference: Protein decapentaplegic
member entity reference: Bone morphogenetic protein 3
member entity reference: Metalloendopeptidase
member entity reference: Bone morphogenetic protein 8A
member entity reference: Embryonic growth/differentiation factor 1
member entity reference: BMP2 protein
member entity reference: Bone morphogenetic protein 2
member entity reference: Growth/differentiation factor 11
member entity reference: Activin beta A subunit
member entity reference: Nodal growth differentiation factor
member entity reference: Bone morphogenetic protein 7
member entity reference: INHBA isoform 1
member entity reference: Glial cell derived neurotrophic factor
member entity reference: UNC-129
member entity reference: Growth differentiation factor 5
member entity reference: Bone morphogenetic protein 6
member entity reference: INHBE isoform 2
member entity reference: Dauer larva development regulatory growth factor daf-7
member entity reference: Tolloid-like protein 2
member entity reference: Protein 60A
member entity reference: Inhibin beta A chain
member entity reference: BMP5
member entity reference: Transforming growth factor beta-1 proprotein
member entity reference: Growth/differentiation factor 10
member entity reference: Inhibin subunit beta C
member entity reference: Growth differentiation factor 9
member entity reference: Bone morphogenetic protein 8B
member entity reference: Ceramide synthase 1
member entity reference: BMP-2
member entity reference: Inhibin subunit beta A
member entity reference: BMP6 isoform 1
member entity reference: Activin beta-C chain
member entity reference: Inhibin beta B chain
member entity reference: Bone morphogenetic protein 5
member entity reference: BMP7 isoform 2
member entity reference: Bone morphogenetic protein 2 (Fragment)
member entity reference: Growth/differentiation factor 2
member entity reference: Glial cell line-derived neurotrophic factor
member entity reference: Southpaw (Fragment)

uniprot F6VUD5 506
type: UnificationXref
id: F6VUD5
db: uniprot

uniprot P55107 631
type: UnificationXref
id: P55107
db: uniprot

uniprot Q95ME4 283
type: UnificationXref
id: Q95ME4
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 221

uniprot Q7PVR1 875
type: UnificationXref
id: Q7PVR1
db: uniprot

uniprot F1PCC1 77
type: UnificationXref
id: F1PCC1
db: uniprot

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
type: ProteinReference
xref: uniprot Q8CF89 777
xref: PTHR13832:SF533
organism: Mus musculus

GTPase HRas isoform 1
type: ProteinReference
xref: uniprot F7F5K9 233
xref: PTHR24070:SF385
organism: Macaca mulatta

Smurfs
type: ProteinReference
xref: P01279
standard name: Smad ubiquitination regulatory factors
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.Smurfs
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: E3 ubiquitin-protein ligase SMURF2
member entity reference: E3 ubiquitin-protein ligase
member entity reference: SMAD-specific E3 ubiquitin protein ligase 2
member entity reference: E3 ubiquitin-protein ligase Smurf1
member entity reference: E3 ubiquitin-protein ligase SMURF1
member entity reference: SMAD specific E3 ubiquitin protein ligase 2
member entity reference: Uncharacterized protein

uniprot A5PJI9 456
type: UnificationXref
id: A5PJI9
db: uniprot

Transcription factor jun-B
type: ProteinReference
xref: uniprot Q0VBZ5 371
xref: PTHR11462:SF37
organism: Bos taurus

Metalloendopeptidase
type: ProteinReference
xref: PTHR45645:SF8
xref: uniprot Q9VC47 691
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__TAK-RIGHT__TAK-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 912
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 913
left: TAK
interaction type: STATE_TRANSITION
right: TAK

uniprot Q1JQA2 818
type: UnificationXref
id: Q1JQA2
db: uniprot

Inhibin beta C chain
type: ProteinReference
xref: uniprot Q9WUK5 694
xref: PTHR11848:SF130
organism: Rattus norvegicus

Metalloendopeptidase
type: ProteinReference
xref: uniprot F7C435 516
xref: PTHR45645:SF24
organism: Monodelphis domestica

uniprot Q07258 646
type: UnificationXref
id: Q07258
db: uniprot

uniprot Q95NE7 46
type: UnificationXref
id: Q95NE7
db: uniprot

uniprot O44408 417
type: UnificationXref
id: O44408
db: uniprot

uniprot H2QNQ5 339
type: UnificationXref
id: H2QNQ5
db: uniprot

Growth/differentiation factor 3
type: ProteinReference
xref: PTHR11848:SF38
xref: uniprot Q07104 643
organism: Mus musculus

uniprot O75593 346
type: UnificationXref
id: O75593
db: uniprot

uniprot Q8K348 180
type: UnificationXref
id: Q8K348
db: uniprot

Growth/differentiation factor 9
type: ProteinReference
xref: uniprot Q07105 644
xref: PTHR11848:SF19
organism: Mus musculus

uniprot Q6KF10 663
type: UnificationXref
id: Q6KF10
db: uniprot

Decapping protein 1, isoform A
type: ProteinReference
xref: uniprot Q9W1H5 395
organism: Drosophila melanogaster

uniprot P0C8E4 441
type: UnificationXref
id: P0C8E4
db: uniprot

Inhibin subunit beta B
type: ProteinReference
xref: PTHR11848:SF29
xref: uniprot B0S7E0 459
organism: Danio rerio

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot A0A2I3S5B2 718
organism: Pan troglodytes

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot D3ZZR9 719
organism: Rattus norvegicus

ncbitaxon 5759 272
type: UnificationXref
id: 5759
db: ncbitaxon

Left-right determination factor
type: ProteinReference
xref: PTHR11848:SF175
xref: uniprot A0A0G2JZN0 446
organism: Rattus norvegicus

uniprot Q7Z5Y6 670
type: UnificationXref
id: Q7Z5Y6
db: uniprot

uniprot D3ZAQ2 757
type: UnificationXref
id: D3ZAQ2
db: uniprot

Uncharacterized protein rasB
type: ProteinReference
xref: PTHR24070:SF206
xref: uniprot F0ZI47 224
organism: Dictyostelium purpureum

uniprot H2RCY2 439
type: UnificationXref
id: H2RCY2
db: uniprot

uniprot Q90752 675
type: UnificationXref
id: Q90752
db: uniprot

Uncharacterized protein rasG
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot F0ZWE6 226
organism: Dictyostelium purpureum

uniprot P27539 611
type: UnificationXref
id: P27539
db: uniprot

V-ski avian sarcoma viral oncogene homolog a
type: ProteinReference
xref: uniprot B0S7D7 301
xref: PTHR10005:SF15
organism: Danio rerio

uniprot A0A0G2K612 183
type: UnificationXref
id: A0A0G2K612
db: uniprot

Growth differentiation factor 9
type: ProteinReference
xref: PTHR11848:SF19
xref: uniprot Q32PR5 654
organism: Danio rerio

uniprot F6S4W2 761
type: UnificationXref
id: F6S4W2
db: uniprot

uniprot P36895 160
type: UnificationXref
id: P36895
db: uniprot

uniprot Q6PBJ1 742
type: UnificationXref
id: Q6PBJ1
db: uniprot

Co Smads s8 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Co-Smads
stoichiometric coefficient: 1.0

uniprot Q9Y6L7 697
type: UnificationXref
id: Q9Y6L7
db: uniprot

PANTHER Pathway P00052 1
type: UnificationXref
id: P00052
db: PANTHER Pathway

Activin receptor type-2B
type: ProteinReference
xref: uniprot Q95126 117
xref: PTHR23255:SF70
organism: Bos taurus

RAS related 2
type: ProteinReference
xref: uniprot K7DK66 242
organism: Pan troglodytes

uniprot P10600 589
type: UnificationXref
id: P10600
db: uniprot

Left-right determination factor
type: ProteinReference
xref: PTHR11848:SF232
xref: uniprot H2Q183 539
organism: Pan troglodytes

uniprot Q9WTY9 51
type: UnificationXref
id: Q9WTY9
db: uniprot

uniprot P63085 860
type: UnificationXref
id: P63085
db: uniprot

uniprot A7F3M0 839
type: UnificationXref
id: A7F3M0
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

BMP2 isoform 1
type: ProteinReference
xref: PTHR11848:SF143
xref: uniprot H2QJY1 550
organism: Pan troglodytes

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
type: ProteinReference
xref: PTHR17045:SF6
xref: uniprot A0A0G2JVK0 294
organism: Rattus norvegicus

Transforming growth factor beta-3 proprotein
type: ProteinReference
xref: uniprot P17125 594
xref: PTHR11848:SF34
organism: Mus musculus

JUNB isoform 1
type: ProteinReference
xref: uniprot H2R6C6 341
xref: PTHR11462:SF37
organism: Pan troglodytes

SKI like proto-oncogene
type: ProteinReference
xref: PTHR10005:SF3
xref: uniprot E2RIZ5 312
organism: Canis lupus familiaris

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot Q7QD16 68
organism: Anopheles gambiae

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot Q6DIZ6 825
xref: PTHR13703:SF41
organism: Xenopus tropicalis

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 270

TGF-beta receptor type-2
type: ProteinReference
xref: PTHR23255:SF55
xref: uniprot Q90999 116
organism: Gallus gallus

uniprot O96660 805
type: UnificationXref
id: O96660
db: uniprot

Transcription factor jun-D
type: ProteinReference
xref: uniprot P17535 362
xref: PTHR11462:SF7
organism: Homo sapiens

RAS related 2
type: ProteinReference
xref: uniprot F7FU89 235
organism: Ornithorhynchus anatinus

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot H2R545 200
xref: PTHR11254:SF293
organism: Pan troglodytes

uniprot F7A9B7 196
type: UnificationXref
id: F7A9B7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QN59 284
organism: Macaca mulatta

uniprot F1MMW7 133
type: UnificationXref
id: F1MMW7
db: uniprot

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 747

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot H2QHI6 725
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TKR2 503
xref: PTHR11848:SF39
organism: Macaca mulatta

Bone morphogenetic protein 15
type: ProteinReference
xref: PTHR11848:SF22
xref: uniprot Q9Z0L4 700
organism: Mus musculus

Uncharacterized protein rasS
type: ProteinReference
xref: uniprot F0ZVH9 225
xref: PTHR24070:SF380
organism: Dictyostelium purpureum

uniprot A0A1D5QLH3 433
type: UnificationXref
id: A0A1D5QLH3
db: uniprot

uniprot F6ZYQ1 512
type: UnificationXref
id: F6ZYQ1
db: uniprot

uniprot O88406 769
type: UnificationXref
id: O88406
db: uniprot

uniprot Q9VMT1 182
type: UnificationXref
id: Q9VMT1
db: uniprot

uniprot Q09472 370
type: UnificationXref
id: Q09472
db: uniprot

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9WUI1 52
xref: PTHR24055:SF109
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r21 915
type: Stoichiometry
physical entity: p42/p44MAPKs
stoichiometric coefficient: 1.0

uniprot P27040 100
type: UnificationXref
id: P27040
db: uniprot

PARTICIPANT STOICHIOMETRY r21 914
type: Stoichiometry
physical entity: p42/p44MAPKs
stoichiometric coefficient: 1.0

uniprot K7ALD8 93
type: UnificationXref
id: K7ALD8
db: uniprot

uniprot Q13873 108
type: UnificationXref
id: Q13873
db: uniprot

uniprot P43026 618
type: UnificationXref
id: P43026
db: uniprot

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

uniprot Q62312 111
type: UnificationXref
id: Q62312
db: uniprot

Growth/differentiation factor 8
type: ProteinReference
xref: uniprot O42220 571
xref: PTHR11848:SF150
organism: Gallus gallus

uniprot F1MD32 313
type: UnificationXref
id: F1MD32
db: uniprot

uniprot P25723 607
type: UnificationXref
id: P25723
db: uniprot

PTHR12173:SF1
type: RelationshipXref
id: PTHR12173:SF1
db: PANTHER Family
relationship type: By Homology

Growth/differentiation factor 8
type: ProteinReference
xref: PTHR11848:SF150
xref: uniprot O42222 572
organism: Danio rerio

Mitogen-activated protein kinase p38a
type: ProteinReference
xref: uniprot O62618 34
xref: PTHR24055:SF238
organism: Drosophila melanogaster

uniprot Q06900 172
type: UnificationXref
id: Q06900
db: uniprot

GDF7 isoform 1
type: ProteinReference
xref: PTHR11848:SF160
xref: uniprot H2QHH9 549
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 876
organism: Danio rerio

uniprot Q61271 176
type: UnificationXref
id: Q61271
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BGS3 471
xref: PTHR11848:SF139
organism: Bos taurus

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 246

uniprot F7F5K9 233
type: UnificationXref
id: F7F5K9
db: uniprot

PTHR17045:SF7
type: RelationshipXref
id: PTHR17045:SF7
db: PANTHER Family
relationship type: By Homology

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
type: ProteinReference
xref: uniprot F7H8X1 775
xref: PTHR13832:SF533
organism: Macaca mulatta

PTHR17045:SF6
type: RelationshipXref
id: PTHR17045:SF6
db: PANTHER Family
relationship type: By Homology

PTHR17045:SF5
type: RelationshipXref
id: PTHR17045:SF5
db: PANTHER Family
relationship type: By Homology

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 33

PTHR13703:SF61
type: RelationshipXref
id: PTHR13703:SF61
db: PANTHER Family
relationship type: By Homology

uniprot P07713 584
type: UnificationXref
id: P07713
db: uniprot

uniprot E2R174 129
type: UnificationXref
id: E2R174
db: uniprot

RSmads s4 sa5 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.04441521524691084
comment: MODIFICATION_RESIDUE_NAME=

PTHR13703:SF59
type: RelationshipXref
id: PTHR13703:SF59
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3SY88 299
type: UnificationXref
id: A0A2I3SY88
db: uniprot

Mitogen-activated protein kinase KSS1
type: ProteinReference
xref: uniprot P14681 853
organism: Saccharomyces cerevisiae

Activin beta A subunit
type: ProteinReference
xref: uniprot Q8QGE3 673
xref: PTHR11848:SF264
organism: Danio rerio

uniprot A0A1D5Q7V1 779
type: UnificationXref
id: A0A1D5Q7V1
db: uniprot

Evidence 771
type: Evidence
evidence code: IGI
comment: Website http://flybase.org/reports/FBgn0020493.html

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF36
xref: uniprot E2RCX7 785
organism: Canis lupus familiaris

uniprot O77627 347
type: UnificationXref
id: O77627
db: uniprot

TGF-beta receptor type-2
type: ProteinReference
xref: PTHR23255:SF55
xref: uniprot F6Q1B1 81
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 400
xref: PTHR24055:SF162
organism: Gallus gallus

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot E1BH37 759
xref: PTHR13703:SF28
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot A8X1S0 405
organism: Caenorhabditis briggsae

Inhibin beta B chain
type: ProteinReference
xref: uniprot P09529 588
xref: PTHR11848:SF29
organism: Homo sapiens

Growth/differentiation factor 15
type: ProteinReference
xref: PTHR11848:SF78
xref: uniprot Q9Z0J7 699
organism: Mus musculus

Growth/differentiation factor 15
type: ProteinReference
xref: PTHR11848:SF78
xref: uniprot Q9Z0J6 698
organism: Rattus norvegicus

uniprot F6T6T3 325
type: UnificationXref
id: F6T6T3
db: uniprot

uniprot P97588 814
type: UnificationXref
id: P97588
db: uniprot

uniprot O88959 578
type: UnificationXref
id: O88959
db: uniprot

Mothers against decapentaplegic homolog 9
type: ProteinReference
xref: PTHR13703:SF41
xref: uniprot O15198 802
organism: Homo sapiens

uniprot Q9V853 204
type: UnificationXref
id: Q9V853
db: uniprot

uniprot P42003 807
type: UnificationXref
id: P42003
db: uniprot

uniprot O61443 32
type: UnificationXref
id: O61443
db: uniprot

PTHR11848:SF78
type: RelationshipXref
id: PTHR11848:SF78
db: PANTHER Family
relationship type: By Homology

PTHR19304:SF9
type: RelationshipXref
id: PTHR19304:SF9
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q6P023 873
xref: PTHR24055:SF203
organism: Danio rerio

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot F1PGW4 78
xref: PTHR23255:SF70
organism: Canis lupus familiaris

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot A0A2I3TGY5 184
xref: PTHR11254:SF300
organism: Pan troglodytes

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

PTHR13703:SF44
type: RelationshipXref
id: PTHR13703:SF44
db: PANTHER Family
relationship type: By Homology

PTHR13703:SF41
type: RelationshipXref
id: PTHR13703:SF41
db: PANTHER Family
relationship type: By Homology

PTHR13703:SF42
type: RelationshipXref
id: PTHR13703:SF42
db: PANTHER Family
relationship type: By Homology

uniprot Q64729 178
type: UnificationXref
id: Q64729
db: uniprot

BMP5 isoform 1
type: ProteinReference
xref: uniprot H2QT84 556
xref: PTHR11848:SF139
organism: Pan troglodytes

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF45
xref: uniprot F7BDU6 58
organism: Xenopus tropicalis

uniprot P92208 424
type: UnificationXref
id: P92208
db: uniprot

uniprot Q64280 657
type: UnificationXref
id: Q64280
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1P630 406
xref: PTHR24055:SF172
organism: Canis lupus familiaris

uniprot W4XBC1 703
type: UnificationXref
id: W4XBC1
db: uniprot

Metalloendopeptidase
type: ProteinReference
xref: PTHR45645:SF26
xref: uniprot A0A1D5QYV0 450
organism: Macaca mulatta

PTHR11848:SF43
type: RelationshipXref
id: PTHR11848:SF43
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF44
type: RelationshipXref
id: PTHR11848:SF44
db: PANTHER Family
relationship type: By Homology

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 59

ncbitaxon 251221 747
type: UnificationXref
id: 251221
db: ncbitaxon

uniprot F1MKY4 285
type: UnificationXref
id: F1MKY4
db: uniprot

PTHR13703:SF36
type: RelationshipXref
id: PTHR13703:SF36
db: PANTHER Family
relationship type: By Homology

SKI like proto-oncogene
type: ProteinReference
xref: PTHR10005:SF3
xref: uniprot F1P0N0 317
organism: Gallus gallus

mRNA-decapping enzyme 1B
type: ProteinReference
xref: uniprot Q8IZD4 376
organism: Homo sapiens

PTHR13703:SF54
type: RelationshipXref
id: PTHR13703:SF54
db: PANTHER Family
relationship type: By Homology

RSmads s4 sa5 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9LQQ9 881
organism: Arabidopsis thaliana

uniprot F7F4C3 332
type: UnificationXref
id: F7F4C3
db: uniprot

ncbitaxon 9615 14
type: UnificationXref
id: 9615
db: ncbitaxon

Protein DVR-1
type: ProteinReference
xref: PTHR11848:SF259
xref: uniprot P35621 615
organism: Danio rerio

PTHR13703:SF53
type: RelationshipXref
id: PTHR13703:SF53
db: PANTHER Family
relationship type: By Homology

Peptidyl-prolyl cis-trans isomerase FKBP1A
type: ProteinReference
xref: PTHR10516:SF301
xref: uniprot P62942 736
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2R0G7 416
xref: PTHR24055:SF222
organism: Pan troglodytes

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF53
xref: uniprot A0A1D5Q1C9 778
organism: Macaca mulatta

uniprot A0A3Q1LWJ8 402
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

uniprot Q9CUN6 201
type: UnificationXref
id: Q9CUN6
db: uniprot

P38 s63 a72 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11848:SF54
type: RelationshipXref
id: PTHR11848:SF54
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot O43318 440
organism: Homo sapiens

uniprot J9NRZ4 342
type: UnificationXref
id: J9NRZ4
db: uniprot

uniprot P53778 36
type: UnificationXref
id: P53778
db: uniprot

PTHR13703:SF23
type: RelationshipXref
id: PTHR13703:SF23
db: PANTHER Family
relationship type: By Homology

uniprot F1PDL1 489
type: UnificationXref
id: F1PDL1
db: uniprot

uniprot F7HMW7 531
type: UnificationXref
id: F7HMW7
db: uniprot

Transforming growth factor beta
type: ProteinReference
xref: PTHR11848:SF125
xref: uniprot F1R741 497
organism: Danio rerio

Transforming growth factor beta
type: ProteinReference
xref: PTHR11848:SF34
xref: uniprot H2Q8N5 546
organism: Pan troglodytes

PTHR11848:SF19
type: RelationshipXref
id: PTHR11848:SF19
db: PANTHER Family
relationship type: By Homology

uniprot F1P3H0 136
type: UnificationXref
id: F1P3H0
db: uniprot

Mothers against decapentaplegic homolog
type: DnaReference
xref: PTHR13703:SF44
organism: Canis lupus familiaris

Forkhead box H1
type: ProteinReference
xref: PTHR47316:SF1
xref: uniprot G3V7Y6 335
organism: Rattus norvegicus

PTHR11848:SF22
type: RelationshipXref
id: PTHR11848:SF22
db: PANTHER Family
relationship type: By Homology

uniprot F6RRA8 323
type: UnificationXref
id: F6RRA8
db: uniprot

uniprot P87373 636
type: UnificationXref
id: P87373
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P49186 420
xref: PTHR24055:SF172
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TKL3 408
xref: PTHR24055:SF222
organism: Xenopus tropicalis

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P49187 421
xref: PTHR24055:SF162
organism: Rattus norvegicus

Bone morphogenetic protein 6
type: ProteinReference
xref: uniprot P20722 599
xref: PTHR11848:SF137
organism: Mus musculus

uniprot P32252 263
type: UnificationXref
id: P32252
db: uniprot

PTHR11848:SF29
type: RelationshipXref
id: PTHR11848:SF29
db: PANTHER Family
relationship type: By Homology

uniprot H2PYP1 336
type: UnificationXref
id: H2PYP1
db: uniprot

uniprot F7HAA9 528
type: UnificationXref
id: F7HAA9
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene Transcription
controller: Complex (Co-activators corepressors/Co-Smads/ RSmads)

uniprot P27037 98
type: UnificationXref
id: P27037
db: uniprot

PTHR11848:SF34
type: RelationshipXref
id: PTHR11848:SF34
db: PANTHER Family
relationship type: By Homology

ncbitaxon 189518 750
type: UnificationXref
id: 189518
db: ncbitaxon

uniprot Q28043 110
type: UnificationXref
id: Q28043
db: uniprot

PTHR11848:SF38
type: RelationshipXref
id: PTHR11848:SF38
db: PANTHER Family
relationship type: By Homology

PTHR11848:SF39
type: RelationshipXref
id: PTHR11848:SF39
db: PANTHER Family
relationship type: By Homology

PTHR13703:SF25
type: RelationshipXref
id: PTHR13703:SF25
db: PANTHER Family
relationship type: By Homology

PTHR13703:SF28
type: RelationshipXref
id: PTHR13703:SF28
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9258 61
type: UnificationXref
id: 9258
db: ncbitaxon

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF58
xref: uniprot F1MMW7 133
organism: Bos taurus

I-Smads
type: Protein
entity reference: I-Smads
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A8E7N9 458
type: UnificationXref
id: A8E7N9
db: uniprot

uniprot Q7QH71 292
type: UnificationXref
id: Q7QH71
db: uniprot

Bone morphogenetic protein receptor type-1A
type: ProteinReference
xref: uniprot Q78EA7 179
xref: PTHR23255:SF50
organism: Rattus norvegicus

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F6YCR1 794
xref: PTHR13703:SF41
organism: Macaca mulatta

Growth differentiation factor 7
type: ProteinReference
xref: uniprot F6Z923 508
xref: PTHR11848:SF160
organism: Xenopus tropicalis

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: uniprot Q1RMX1 712
xref: PTHR15505:SF1
organism: Bos taurus

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F6UAA8 790
xref: PTHR13703:SF41
organism: Monodelphis domestica

uniprot K7ALD7 240
type: UnificationXref
id: K7ALD7
db: uniprot

Protein cbp-1
type: ProteinReference
xref: uniprot P34545 366
xref: PTHR13808:SF1
organism: Caenorhabditis elegans

RAS-related 2
type: ProteinReference
xref: uniprot Q568M0 276
organism: Danio rerio

uniprot P70539 166
type: UnificationXref
id: P70539
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__TGFbetareceptors-_TGFbeta-RIGHT__Complex__TGFbetareceptor_I_TGFbetareceptor_II__TGF_beta_-_r9
control type: INHIBITION
controller: BAMBI

Bos taurus
type: BioSource
xref: ncbitaxon 9913 5

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF45
xref: uniprot B0JYL0 56
organism: Bos taurus

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot Q9I8V2 830
organism: Danio rerio

BMP and activin membrane-bound inhibitor homolog
type: ProteinReference
xref: uniprot Q91XN4 715
xref: PTHR15505:SF1
organism: Rattus norvegicus

uniprot F6SCP7 501
type: UnificationXref
id: F6SCP7
db: uniprot

uniprot Q13485 67
type: UnificationXref
id: Q13485
db: uniprot

uniprot Q9Z1B7 53
type: UnificationXref
id: Q9Z1B7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11848:SF139
xref: uniprot F7H4M7 525
organism: Macaca mulatta

uniprot Q07731 647
type: UnificationXref
id: Q07731
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__I_SMAD-RIGHT__I_SMAD-_re26
control type: ACTIVATION
controller: P38

uniprot O43541 768
type: UnificationXref
id: O43541
db: uniprot

uniprot F1N4I7 315
type: UnificationXref
id: F1N4I7
db: uniprot

Ras-GTP
type: ProteinReference
xref: P01280
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.Ras-GTP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ras-like protein rasS
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: GTPase HRas
member entity reference: RAS related 2
member entity reference: Uncharacterized protein rasC
member entity reference: Protein CBR-LET-60
member entity reference: Protein CBR-CDC-42
member entity reference: GTPase NRas
member entity reference: Uncharacterized protein
member entity reference: Ras-like protein rasG
member entity reference: Ras-like protein 1
member entity reference: GTPase HRas isoform 1
member entity reference: NRAS protein
member entity reference: Protein CBR-RAB-10
member entity reference: Ras-related protein R-Ras
member entity reference: Uncharacterized protein rasS
member entity reference: Ras-related protein Rab-10
member entity reference: RAS related
member entity reference: Ras-like protein
member entity reference: Ras-like protein rasC
member entity reference: Ras protein let-60
member entity reference: Predicted protein
member entity reference: Protein CBR-RAS-1
member entity reference: GTP-binding protein Rheb homolog 1
member entity reference: AGAP002219-PA
member entity reference: GTPase KRas
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: Ras-like protein rasB
member entity reference: Uncharacterized protein rasB
member entity reference: HRAS isoform 2
member entity reference: Related RAS viral (R-ras) oncogene homolog
member entity reference: RAS-related 2
member entity reference: GTP binding protein
member entity reference: Ras-like protein 2
member entity reference: Uncharacterized protein rasG
member entity reference: Ras family GTPase
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: NRAS isoform 1
member entity reference: Protein ras-1
member entity reference: Uncharacterized protein rasD
member entity reference: Ras-like protein rasD
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: HRas proto-oncogene, GTPase a

uniprot A0A1D5Q1C9 778
type: UnificationXref
id: A0A1D5Q1C9
db: uniprot

uniprot E2R6T4 310
type: UnificationXref
id: E2R6T4
db: uniprot

uniprot F7EI48 848
type: UnificationXref
id: F7EI48
db: uniprot

uniprot Q04970 268
type: UnificationXref
id: Q04970
db: uniprot

Bone morphogenetic protein 8a
type: ProteinReference
xref: uniprot D3ZTI5 465
xref: PTHR11848:SF119
organism: Rattus norvegicus

uniprot F1N3W8 189
type: UnificationXref
id: F1N3W8
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot A0A1D5QUK7 120
xref: PTHR23255:SF61
organism: Macaca mulatta

E1A binding protein p300
type: ProteinReference
xref: uniprot H2QLS0 338
xref: PTHR13808:SF29
organism: Pan troglodytes

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: uniprot P97588 814
xref: PTHR13703:SF23
organism: Rattus norvegicus

Dwarfin sma-2
type: ProteinReference
xref: uniprot Q02330 815
xref: PTHR13703:SF61
organism: Caenorhabditis elegans

PTHR23255:SF98
type: RelationshipXref
id: PTHR23255:SF98
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: PTHR23255:SF66
xref: uniprot F7HG73 148
organism: Macaca mulatta

PTHR23255:SF96
type: RelationshipXref
id: PTHR23255:SF96
db: PANTHER Family
relationship type: By Homology

uniprot Q9RTC6 753
type: UnificationXref
id: Q9RTC6
db: uniprot

uniprot H2RA86 851
type: UnificationXref
id: H2RA86
db: uniprot

PTHR11829:SF340
type: RelationshipXref
id: PTHR11829:SF340
db: PANTHER Family
relationship type: By Homology

uniprot Q8TAD8 377
type: UnificationXref
id: Q8TAD8
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A7STP5 211
xref: PTHR24070:SF420
organism: Nematostella vectensis

uniprot F1NTD3 135
type: UnificationXref
id: F1NTD3
db: uniprot

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F1MD32 313
organism: Bos taurus

uniprot P79737 267
type: UnificationXref
id: P79737
db: uniprot

uniprot E2RA74 130
type: UnificationXref
id: E2RA74
db: uniprot

Inhibin beta A chain
type: ProteinReference
xref: PTHR11848:SF133
xref: uniprot P08476 587
organism: Homo sapiens

TAK s1 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TAK
stoichiometric coefficient: 1.0

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 76

uniprot Q9Z2I2 756
type: UnificationXref
id: Q9Z2I2
db: uniprot

uniprot P10833 258
type: UnificationXref
id: P10833
db: uniprot

Protein decapentaplegic
type: ProteinReference
evidence: Evidence 585
xref: PTHR11848:SF54
xref: uniprot P07713 584
organism: Drosophila melanogaster

Ras-like protein
type: ProteinReference
xref: uniprot P0CQ42 255
xref: PTHR24070:SF17
organism: Cryptococcus neoformans

TGF-beta receptor type-2
type: ProteinReference
xref: PTHR23255:SF55
xref: uniprot P38438 102
organism: Rattus norvegicus

uniprot O35312 570
type: UnificationXref
id: O35312
db: uniprot

TransformIng Growth factor beta family
type: ProteinReference
xref: uniprot O16273 568
xref: PTHR11848:SF263
organism: Caenorhabditis elegans

uniprot F6YMS3 795
type: UnificationXref
id: F6YMS3
db: uniprot

ncbitaxon 284811 745
type: UnificationXref
id: 284811
db: ncbitaxon

uniprot F6WV79 409
type: UnificationXref
id: F6WV79
db: uniprot

uniprot A0A2I3RZ31 401
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

uniprot F7DD95 519
type: UnificationXref
id: F7DD95
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F7F5X1 234
organism: Monodelphis domestica

Ski oncogene
type: ProteinReference
xref: uniprot P12755 354
xref: PTHR10005:SF15
organism: Homo sapiens

Cell surface receptor daf-1
type: ProteinReference
xref: PTHR23255:SF71
xref: uniprot P20792 97
organism: Caenorhabditis elegans

Peptidyl-prolyl cis-trans isomerase
type: ProteinReference
xref: uniprot Q7NMC5 746
organism: Gloeobacter violaceus

Metalloendopeptidase
type: ProteinReference
xref: uniprot D3Z8U5 463
xref: PTHR45645:SF26
organism: Rattus norvegicus

uniprot P09450 352
type: UnificationXref
id: P09450
db: uniprot

uniprot Q39021 864
type: UnificationXref
id: Q39021
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot F7HJS7 149
xref: PTHR23255:SF62
organism: Macaca mulatta

Activin receptor type-2A
type: ProteinReference
xref: PTHR23255:SF64
xref: uniprot P38444 103
organism: Rattus norvegicus

Activin receptor type-2B
type: ProteinReference
xref: uniprot P38445 104
xref: PTHR23255:SF70
organism: Rattus norvegicus

uniprot Q91Y86 427
type: UnificationXref
id: Q91Y86
db: uniprot

ncbitaxon 10090 27
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot D3ZWL1 304
type: UnificationXref
id: D3ZWL1
db: uniprot

Ski-like protein
type: ProteinReference
xref: PTHR10005:SF3
xref: uniprot P12757 355
organism: Homo sapiens

RAS related 2
type: ProteinReference
xref: uniprot F1P9Z4 228
organism: Canis lupus familiaris

Metalloendopeptidase
type: ProteinReference
xref: uniprot F1MF35 481
organism: Bos taurus

uniprot F1PLP7 774
type: UnificationXref
id: F1PLP7
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q5F352 279
organism: Gallus gallus

Histone acetyltransferase p300
type: ProteinReference
xref: uniprot F6T7D0 326
xref: PTHR13808:SF29
organism: Macaca mulatta

uniprot A0A1D5NUC4 432
type: UnificationXref
id: A0A1D5NUC4
db: uniprot

uniprot E1BGS3 471
type: UnificationXref
id: E1BGS3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11848:SF165
xref: uniprot F7ACJ7 514
organism: Macaca mulatta

Mothers against decapentaplegic homolog 7
type: DnaReference
xref: PTHR13703:SF44
organism: Mus musculus

Transforming growth factor beta
type: ProteinReference
xref: PTHR11848:SF34
xref: uniprot A6QP91 457
organism: Bos taurus

P01292
type: UnificationXref
id: P01292
db: PANTHER Pathway Component

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 64
xref: PTHR13703:SF45
xref: uniprot O62609 63
organism: Drosophila melanogaster

P01293
type: UnificationXref
id: P01293
db: PANTHER Pathway Component

P01290
type: UnificationXref
id: P01290
db: PANTHER Pathway Component

uniprot F6YTY1 723
type: UnificationXref
id: F6YTY1
db: uniprot

Transforming growth factor, beta 2 (Fragment)
type: ProteinReference
xref: uniprot F8W4A6 532
xref: PTHR11848:SF141
organism: Danio rerio

P01291
type: UnificationXref
id: P01291
db: PANTHER Pathway Component

Glial cell line-derived neurotrophic factor
type: ProteinReference
xref: uniprot Q07731 647
xref: PTHR12173:SF1
organism: Rattus norvegicus

uniprot Q02330 815
type: UnificationXref
id: Q02330
db: uniprot

Ras-related protein R-Ras
type: ProteinReference
xref: uniprot P10833 258
xref: PTHR24070:SF245
organism: Mus musculus

Jun proto-oncogene
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot F6RYL1 324
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR11848:SF22
xref: uniprot F7H957 526
organism: Macaca mulatta

Histone acetyltransferase p300
type: ProteinReference
xref: uniprot B2RWS6 303
xref: PTHR13808:SF29
organism: Mus musculus

Dwarfin sma-4
type: ProteinReference
xref: uniprot P45897 808
organism: Caenorhabditis elegans

Serine/threonine-protein kinase receptor
type: ProteinReference
evidence: Evidence 71
xref: PTHR23255:SF98
xref: uniprot A0A0B4KG59 70
organism: Drosophila melanogaster

Bone morphogenetic protein 8A
type: ProteinReference
xref: uniprot Q7Z5Y6 670
xref: PTHR11848:SF119
organism: Homo sapiens

P01280
type: UnificationXref
id: P01280
db: PANTHER Pathway Component

P01281
type: UnificationXref
id: P01281
db: PANTHER Pathway Component

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F7H4T8 147
xref: PTHR23255:SF50
organism: Macaca mulatta

P01282
type: UnificationXref
id: P01282
db: PANTHER Pathway Component

Peptidyl-prolyl cis-trans isomerase FKBP2
type: ProteinReference
xref: uniprot P45878 734
organism: Mus musculus

uniprot A8XGW3 215
type: UnificationXref
id: A8XGW3
db: uniprot

P01287
type: UnificationXref
id: P01287
db: PANTHER Pathway Component

uniprot Q6P023 873
type: UnificationXref
id: Q6P023
db: uniprot

P01288
type: UnificationXref
id: P01288
db: PANTHER Pathway Component

P01289
type: UnificationXref
id: P01289
db: PANTHER Pathway Component

Peptidyl-prolyl cis-trans isomerase FKBP1A
type: ProteinReference
xref: uniprot Q62658 741
organism: Rattus norvegicus

P01283
type: UnificationXref
id: P01283
db: PANTHER Pathway Component

uniprot Q8BHE5 671
type: UnificationXref
id: Q8BHE5
db: uniprot

P01284
type: UnificationXref
id: P01284
db: PANTHER Pathway Component

P01285
type: UnificationXref
id: P01285
db: PANTHER Pathway Component

P01286
type: UnificationXref
id: P01286
db: PANTHER Pathway Component

Growth/differentiation factor 10
type: ProteinReference
xref: PTHR11848:SF145
xref: uniprot Q08DX6 648
organism: Bos taurus

Bone morphogenetic protein 2
type: ProteinReference
xref: uniprot O93369 579
xref: PTHR11848:SF143
organism: Danio rerio

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 863

TAB s2 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TAB
stoichiometric coefficient: 1.0

Ras-GTP
type: Protein
entity reference: Ras-GTP
feature: ACTIVE 54
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6ZTS0 21
type: UnificationXref
id: F6ZTS0
db: uniprot

uniprot Q68IN2 660
type: UnificationXref
id: Q68IN2
db: uniprot

Tolloid-like protein 2
type: ProteinReference
xref: PTHR45645:SF15
xref: uniprot Q9Y6L7 697
organism: Homo sapiens

uniprot F7GS64 334
type: UnificationXref
id: F7GS64
db: uniprot

uniprot O54835 803
type: UnificationXref
id: O54835
db: uniprot

PTHR11254:SF293
type: RelationshipXref
id: PTHR11254:SF293
db: PANTHER Family
relationship type: By Homology

Anti-dorsalizing morphogenic protein
type: ProteinReference
xref: uniprot F1R5Z7 496
xref: PTHR11848:SF241
organism: Danio rerio

Inhibin subunit beta C
type: ProteinReference
xref: uniprot F7DD95 519
xref: PTHR11848:SF6
organism: Xenopus tropicalis

uniprot A8X3D3 782
type: UnificationXref
id: A8X3D3
db: uniprot

Metalloendopeptidase
type: ProteinReference
xref: PTHR45645:SF24
xref: uniprot F1M798 479
organism: Rattus norvegicus

uniprot P13497 593
type: UnificationXref
id: P13497
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P01111 243
organism: Homo sapiens

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot E2R174 129
xref: PTHR23255:SF66
organism: Canis lupus familiaris

uniprot F7HMT9 530
type: UnificationXref
id: F7HMT9
db: uniprot

GTPase HRas
type: ProteinReference
xref: uniprot P01112 244
xref: PTHR24070:SF385
organism: Homo sapiens

uniprot F7CL00 708
type: UnificationXref
id: F7CL00
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF61
xref: uniprot Q7Q8L8 826
organism: Anopheles gambiae

uniprot Q62658 741
type: UnificationXref
id: Q62658
db: uniprot

SMAD-specific E3 ubiquitin protein ligase 2
type: ProteinReference
xref: uniprot F1M3F2 187
xref: PTHR11254:SF300
organism: Rattus norvegicus

TAB
type: ProteinReference
xref: P01290
standard name: TAK binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.TAB
comment: ENTITY_REFERENCE_NOTES=
member entity reference: RCG59826
member entity reference: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
member entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
member entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha

Left-right determination factor 2
type: ProteinReference
xref: PTHR11848:SF232
xref: uniprot O00292 564
organism: Homo sapiens

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

BMP4 isoform 1
type: ProteinReference
xref: uniprot H2Q8B9 545
xref: PTHR11848:SF165
organism: Pan troglodytes

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

uniprot F7H9S4 527
type: UnificationXref
id: F7H9S4
db: uniprot

uniprot P01112 244
type: UnificationXref
id: P01112
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A2I3RZ31 401
xref: PTHR24055:SF162
organism: Pan troglodytes

Growth/differentiation factor 15
type: ProteinReference
xref: PTHR11848:SF78
xref: uniprot Q99988 681
organism: Homo sapiens

Bone morphogenetic protein 15
type: ProteinReference
xref: uniprot O95972 582
xref: PTHR11848:SF22
organism: Homo sapiens

uniprot H2RCQ5 801
type: UnificationXref
id: H2RCQ5
db: uniprot

uniprot Q56I99 820
type: UnificationXref
id: Q56I99
db: uniprot

uniprot H2Q6B2 544
type: UnificationXref
id: H2Q6B2
db: uniprot

uniprot Q39026 868
type: UnificationXref
id: Q39026
db: uniprot

PTHR24070:SF380
type: RelationshipXref
id: PTHR24070:SF380
db: PANTHER Family
relationship type: By Homology

SARA
type: Protein
entity reference: SARA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9HCE7 203
type: UnificationXref
id: Q9HCE7
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q91Y86 427
xref: PTHR24055:SF222
organism: Mus musculus

uniprot J9NW61 709
type: UnificationXref
id: J9NW61
db: uniprot

uniprot P47811 35
type: UnificationXref
id: P47811
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__I_SMAD-RIGHT__I_SMAD-_re26
control type: ACTIVATION
controller: Complex (Co-activators corepressors/Co-Smads/ RSmads)

uniprot D3Z8U5 463
type: UnificationXref
id: D3Z8U5
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9WTY9 51
organism: Rattus norvegicus

uniprot F7GN93 414
type: UnificationXref
id: F7GN93
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F1QXZ9 787
organism: Danio rerio

Inhibin beta A chain
type: ProteinReference
xref: uniprot P18331 598
xref: PTHR11848:SF133
organism: Rattus norvegicus

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

uniprot F7CB21 517
type: UnificationXref
id: F7CB21
db: uniprot

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

uniprot Q9QYW4 686
type: UnificationXref
id: Q9QYW4
db: uniprot

Bone morphogenetic protein 3
type: ProteinReference
xref: uniprot H2R170 560
xref: PTHR11848:SF145
organism: Pan troglodytes

ncbitaxon 559292 246
type: UnificationXref
id: 559292
db: ncbitaxon

Metalloendopeptidase
type: ProteinReference
xref: uniprot F6UN99 505
organism: Monodelphis domestica

uniprot P58500 443
type: UnificationXref
id: P58500
db: uniprot

uniprot Q8JFP9 672
type: UnificationXref
id: Q8JFP9
db: uniprot

AGAP000824-PA
type: ProteinReference
xref: PTHR11848:SF263
xref: uniprot Q7PNK1 667
organism: Anopheles gambiae

Growth differentiation factor 5
type: ProteinReference
xref: uniprot E2R0W8 473
xref: PTHR11848:SF44
organism: Canis lupus familiaris

Histone acetyltransferase HAC1
type: ProteinReference
xref: uniprot Q9C5X9 387
xref: PTHR13808:SF1
organism: Arabidopsis thaliana

uniprot A1Z7L8 124
type: UnificationXref
id: A1Z7L8
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1PCC1 77
xref: PTHR23255:SF63
organism: Canis lupus familiaris

FKBP12
type: ProteinReference
xref: P01288
standard name: FK506 binding protein 12KDa
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.FKBP12
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Peptidyl-prolyl cis-trans isomerase
member entity reference: Peptidyl-prolyl cis-trans isomerase FKBP1A
member entity reference: FK506-binding protein 1
member entity reference: 12 kDa FK506-binding protein
member entity reference: Peptidylprolyl isomerase
member entity reference: Peptidyl-prolyl cis-trans isomerase FKBP2
member entity reference: Peptidylprolyl isomerase (Fragment)
member entity reference: Peptidyl-prolyl cis-trans isomerase FKBP1B
member entity reference: FK506-binding protein 1A

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

PTHR11462:SF7
type: RelationshipXref
id: PTHR11462:SF7
db: PANTHER Family
relationship type: By Homology

uniprot E1BSJ7 309
type: UnificationXref
id: E1BSJ7
db: uniprot

SKI proto-oncogene
type: ProteinReference
xref: uniprot F6XHC4 329
xref: PTHR10005:SF15
organism: Xenopus tropicalis

uniprot F7HDK4 529
type: UnificationXref
id: F7HDK4
db: uniprot

uniprot E1B8P9 841
type: UnificationXref
id: E1B8P9
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 254

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 745

Evidence 64
type: Evidence
evidence code: TAS
comment: Website http://flybase.org/reports/FBgn0011655.html

uniprot F1PS63 138
type: UnificationXref
id: F1PS63
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PGR5 448
xref: PTHR11848:SF44
organism: Gallus gallus

uniprot Q90YD6 676
type: UnificationXref
id: Q90YD6
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF45
xref: uniprot F7A1M2 57
organism: Monodelphis domestica

uniprot A0A3Q1LMU4 453
type: UnificationXref
id: A0A3Q1LMU4
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot K7ALD8 93
xref: PTHR23255:SF64
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot F6ZGX8 232
organism: Macaca mulatta

uniprot F1NJU6 191
type: UnificationXref
id: F1NJU6
db: uniprot

HRAS isoform 2
type: ProteinReference
xref: uniprot K7ALD7 240
xref: PTHR24070:SF385
organism: Pan troglodytes

uniprot Q62073 444
type: UnificationXref
id: Q62073
db: uniprot

uniprot F1MLT0 482
type: UnificationXref
id: F1MLT0
db: uniprot

uniprot Q04998 640
type: UnificationXref
id: Q04998
db: uniprot

uniprot F6U298 436
type: UnificationXref
id: F6U298
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O02812 24
xref: PTHR24055:SF110
organism: Canis lupus familiaris

FOXH1 isoform 1
type: ProteinReference
xref: PTHR47316:SF1
xref: uniprot H2QWX3 340
organism: Pan troglodytes

uniprot A0A3Q2U980 207
type: UnificationXref
id: A0A3Q2U980
db: uniprot

Co activators corepressors s7 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Co-activators corepressors
stoichiometric coefficient: 1.0

uniprot A0A0B4KG59 70
type: UnificationXref
id: A0A0B4KG59
db: uniprot

Decapping mRNA 1A
type: ProteinReference
xref: uniprot F1PGG7 319
organism: Canis lupus familiaris

uniprot O14793 567
type: UnificationXref
id: O14793
db: uniprot

uniprot Q2NKS8 739
type: UnificationXref
id: Q2NKS8
db: uniprot

uniprot P84025 812
type: UnificationXref
id: P84025
db: uniprot

Bone morphogenetic protein 6
type: ProteinReference
xref: uniprot P22004 605
xref: PTHR11848:SF137
organism: Homo sapiens

Bone morphogenetic protein 5
type: ProteinReference
xref: uniprot P22003 604
xref: PTHR11848:SF139
organism: Homo sapiens

RSmads s41 a42 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.04441521524691084
comment: MODIFICATION_RESIDUE_NAME=

Transforming growth factor beta
type: ProteinReference
xref: PTHR11848:SF141
xref: uniprot F1PKH2 490
organism: Canis lupus familiaris

Uncharacterized protein rasC
type: ProteinReference
xref: PTHR24070:SF251
xref: uniprot F1A411 227
organism: Dictyostelium purpureum

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF62
xref: uniprot F6Q8L1 140
organism: Monodelphis domestica

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

uniprot O08911 26
type: UnificationXref
id: O08911
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 430
xref: PTHR24055:SF172
organism: Mus musculus

GDNF isoform 5
type: ProteinReference
xref: PTHR12173:SF1
xref: uniprot H2R5I7 561
organism: Pan troglodytes

uniprot F6VCH4 328
type: UnificationXref
id: F6VCH4
db: uniprot

uniprot F7EG01 86
type: UnificationXref
id: F7EG01
db: uniprot

uniprot P18870 364
type: UnificationXref
id: P18870
db: uniprot

TGF-beta activated kinase 1 (MAP3K7) binding protein 1
type: ProteinReference
xref: uniprot A0A2I3TT58 773
xref: PTHR13832:SF533
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NUC4 432
organism: Gallus gallus

RSmads s41 a42 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__I_SMAD-RIGHT__I_SMAD-_re26
control type: ACTIVATION
controller: p42/p44MAPKs

uniprot Q5U110 770
type: UnificationXref
id: Q5U110
db: uniprot

uniprot H2QJT5 726
type: UnificationXref
id: H2QJT5
db: uniprot

uniprot Q6UKZ8 666
type: UnificationXref
id: Q6UKZ8
db: uniprot

uniprot Q91YD3 381
type: UnificationXref
id: Q91YD3
db: uniprot

JunD proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot F1PKI6 320
xref: PTHR11462:SF7
organism: Canis lupus familiaris

Fos-related antigen 1
type: ProteinReference
xref: PTHR23351:SF6
xref: uniprot P10158 353
organism: Rattus norvegicus

Mothers against decapentaplegic homolog 3
type: ProteinReference
xref: PTHR13703:SF53
xref: uniprot P84025 812
organism: Rattus norvegicus

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1MCE7 131
xref: PTHR23255:SF50
organism: Bos taurus

Cbp/p300-interacting transactivator 2
type: ProteinReference
xref: PTHR17045:SF7
xref: uniprot Q99967 384
organism: Homo sapiens

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 704

uniprot D3Z8L7 217
type: UnificationXref
id: D3Z8L7
db: uniprot

Cbp/p300-interacting transactivator 1
type: ProteinReference
xref: uniprot Q99966 383
xref: PTHR17045:SF6
organism: Homo sapiens

Gdf11-like
type: ProteinReference
xref: PTHR11848:SF166
xref: uniprot Q8JFP9 672
organism: Danio rerio

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9N272 50
organism: Pan troglodytes

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

uniprot H2QUH0 557
type: UnificationXref
id: H2QUH0
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q84UI5 877
organism: Oryza sativa

uniprot F6ZJX4 511
type: UnificationXref
id: F6ZJX4
db: uniprot

Ras-like protein 2
type: ProteinReference
xref: uniprot P01120 247
xref: PTHR24070:SF17
organism: Saccharomyces cerevisiae

uniprot Q07104 643
type: UnificationXref
id: Q07104
db: uniprot

Growth differentiation factor 1
type: ProteinReference
xref: PTHR11848:SF151
xref: uniprot Q1HI69 649
organism: Rattus norvegicus

SARA
type: ProteinReference
xref: P01281
standard name: Smad anchor for receptor activation
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.SARA
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Zinc finger FYVE domain-containing protein
member entity reference: Zinc finger FYVE domain-containing protein 9
member entity reference: AGAP004049-PA
member entity reference: Zinc finger FYVE domain-containing protein 16
member entity reference: Uncharacterized protein

uniprot Q61831 425
type: UnificationXref
id: Q61831
db: uniprot

uniprot P49003 624
type: UnificationXref
id: P49003
db: uniprot

uniprot P38444 103
type: UnificationXref
id: P38444
db: uniprot

Growth/differentiation factor 3
type: ProteinReference
xref: uniprot Q9NR23 684
xref: PTHR11848:SF38
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot F6TXC2 16
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot V5IKE7 883
organism: Neurospora crassa

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot K7DBC8 343
organism: Pan troglodytes

uniprot P49187 421
type: UnificationXref
id: P49187
db: uniprot

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot Q8I4E5 751
organism: Caenorhabditis elegans

Ras-like protein 1
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot P01119 245
organism: Saccharomyces cerevisiae

uniprot O57460 574
type: UnificationXref
id: O57460
db: uniprot

uniprot H2QJY1 550
type: UnificationXref
id: H2QJY1
db: uniprot

uniprot F1QX69 495
type: UnificationXref
id: F1QX69
db: uniprot

TGFbeta s14 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbeta
stoichiometric coefficient: 1.0

uniprot H2QQ88 800
type: UnificationXref
id: H2QQ88
db: uniprot

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

uniprot P27092 610
type: UnificationXref
id: P27092
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F7EDR2 145
xref: PTHR23255:SF50
organism: Ornithorhynchus anatinus

uniprot A0A1D5Q7U9 297
type: UnificationXref
id: A0A1D5Q7U9
db: uniprot

Co-Smads
type: ProteinReference
xref: P01276
standard name: partner Smads
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.Co-Smads
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mothers against decapentaplegic homolog
member entity reference: Mothers against decapentaplegic homolog 4

TAK
type: Protein
entity reference: TAK
feature: TAK s61 a70 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LTT9 8
xref: PTHR24055:SF110
organism: Bos taurus

Cell surface receptor daf-4
type: ProteinReference
xref: PTHR23255:SF98
xref: uniprot P50488 105
organism: Caenorhabditis elegans

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot A0A1D5QUZ8 838
organism: Macaca mulatta

eco ECO:0000316 302
type: UnificationXref
id: ECO:0000316
db: eco

Metalloendopeptidase
type: ProteinReference
xref: uniprot F7HAA9 528
xref: PTHR45645:SF24
organism: Macaca mulatta

uniprot Q13705 107
type: UnificationXref
id: Q13705
db: uniprot

uniprot Q90YD7 677
type: UnificationXref
id: Q90YD7
db: uniprot

uniprot Q7Q8L8 826
type: UnificationXref
id: Q7Q8L8
db: uniprot

uniprot Q9VC47 691
type: UnificationXref
id: Q9VC47
db: uniprot

uniprot E1BEV7 470
type: UnificationXref
id: E1BEV7
db: uniprot

TGFbeta
type: Protein
entity reference: TGFbeta
comment: SPECIES_TYPE=PROTEIN

uniprot F6X227 507
type: UnificationXref
id: F6X227
db: uniprot

PTHR24055:SF154
type: RelationshipXref
id: PTHR24055:SF154
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 249

Uncharacterized protein
type: ProteinReference
xref: uniprot C3Z3V6 461
xref: PTHR11848:SF54
organism: Branchiostoma floridae

Bone morphogenetic protein 3
type: ProteinReference
xref: PTHR11848:SF144
xref: uniprot F6R9A9 499
organism: Macaca mulatta

uniprot Q39023 866
type: UnificationXref
id: Q39023
db: uniprot

uniprot Q7QD16 68
type: UnificationXref
id: Q7QD16
db: uniprot

Transforming growth factor beta
type: ProteinReference
xref: PTHR11848:SF141
xref: uniprot F1NNP2 487
organism: Gallus gallus

Mothers against decapentaplegic homolog 3
type: ProteinReference
xref: PTHR13703:SF53
xref: uniprot P84023 811
organism: Gallus gallus

Mothers against decapentaplegic homolog
type: DnaReference
evidence: Evidence 771
xref: PTHR13703:SF54
organism: Drosophila melanogaster

uniprot A8WRD7 9
type: UnificationXref
id: A8WRD7
db: uniprot

Mothers against decapentaplegic homolog 3
type: ProteinReference
xref: PTHR13703:SF53
xref: uniprot P84022 810
organism: Homo sapiens

uniprot P45897 808
type: UnificationXref
id: P45897
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot F7A9J8 144
xref: PTHR23255:SF69
organism: Macaca mulatta

uniprot Q0VCT9 372
type: UnificationXref
id: Q0VCT9
db: uniprot

uniprot Q99967 384
type: UnificationXref
id: Q99967
db: uniprot

uniprot P57785 633
type: UnificationXref
id: P57785
db: uniprot

uniprot H2QHH9 549
type: UnificationXref
id: H2QHH9
db: uniprot

uniprot O16273 568
type: UnificationXref
id: O16273
db: uniprot

uniprot Q04999 641
type: UnificationXref
id: Q04999
db: uniprot

uniprot Q7K9H6 290
type: UnificationXref
id: Q7K9H6
db: uniprot

uniprot H2Q663 542
type: UnificationXref
id: H2Q663
db: uniprot

RSmads
type: Protein
entity reference: RSmads
feature: RSmads s4 sa5 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa5 887
feature: RSmads s4 sa5 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Transcription factor jun-B
type: ProteinReference
xref: uniprot P17275 360
xref: PTHR11462:SF37
organism: Homo sapiens

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 212

Dorsal-ventral patterning tolloid-like protein 1
type: ProteinReference
xref: uniprot O57460 574
xref: PTHR45645:SF26
organism: Danio rerio

uniprot H2PYR2 537
type: UnificationXref
id: H2PYR2
db: uniprot

Inhibin beta B chain
type: ProteinReference
xref: uniprot Q04999 641
xref: PTHR11848:SF29
organism: Mus musculus

Inhibin beta A chain
type: ProteinReference
xref: PTHR11848:SF133
xref: uniprot Q04998 640
organism: Mus musculus

MAP3K7 C-terminal-like protein
type: ProteinReference
xref: uniprot P58500 443
xref: PTHR47140:SF1
organism: Mus musculus

FKBP12
type: Protein
entity reference: FKBP12
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F1N3W8 189
xref: PTHR11254:SF300
organism: Bos taurus

uniprot B2RWS6 303
type: UnificationXref
id: B2RWS6
db: uniprot

uniprot Q99966 383
type: UnificationXref
id: Q99966
db: uniprot

uniprot P38438 102
type: UnificationXref
id: P38438
db: uniprot

Evidence 71
type: Evidence
evidence code: TAS
comment: Website http://flybase.org/reports/FBgn0003169.html

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot H2QLB4 850
organism: Pan troglodytes

uniprot P03967 248
type: UnificationXref
id: P03967
db: uniprot

uniprot F6TA61 502
type: UnificationXref
id: F6TA61
db: uniprot

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

uniprot H2QLS0 338
type: UnificationXref
id: H2QLS0
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1MIW7 132
xref: PTHR23255:SF66
organism: Bos taurus

Gene Transcription
type: Pathway

uniprot H2R686 92
type: UnificationXref
id: H2R686
db: uniprot

Co-Smads
type: Protein
entity reference: Co-Smads
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa4 885
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Transforming growth factor beta-3 proprotein
type: ProteinReference
xref: uniprot Q07258 646
xref: PTHR11848:SF34
organism: Rattus norvegicus

Transforming growth factor beta-2 proprotein
type: ProteinReference
xref: uniprot Q07257 645
xref: PTHR11848:SF141
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot A0A1D5Q5Z6 837
organism: Macaca mulatta

PTHR23308:SF36
type: RelationshipXref
id: PTHR23308:SF36
db: PANTHER Family
relationship type: By Homology

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot P45481 367
organism: Mus musculus

uniprot Q9Z0L4 700
type: UnificationXref
id: Q9Z0L4
db: uniprot

PTHR13808:SF30
type: RelationshipXref
id: PTHR13808:SF30
db: PANTHER Family
relationship type: By Homology

GO GO:0005634 3
type: UnificationXref
id: GO:0005634
db: GO

PTHR13808:SF34
type: RelationshipXref
id: PTHR13808:SF34
db: PANTHER Family
relationship type: By Homology

uniprot F6UN99 505
type: UnificationXref
id: F6UN99
db: uniprot

Histone acetyltransferase p300
type: ProteinReference
xref: uniprot Q09472 370
xref: PTHR13808:SF29
organism: Homo sapiens

Peptidylprolyl isomerase
type: ProteinReference
xref: uniprot Q8QGU2 752
organism: Gallus gallus

PTHR10005:SF24
type: RelationshipXref
id: PTHR10005:SF24
db: PANTHER Family
relationship type: By Homology

uniprot P21275 603
type: UnificationXref
id: P21275
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q98950 679
type: UnificationXref
id: Q98950
db: uniprot

TRANSPORT
type: InteractionVocabulary

uniprot Q8BUN5 828
type: UnificationXref
id: Q8BUN5
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF36
xref: uniprot F7CFQ6 796
organism: Monodelphis domestica

uniprot F8W4A6 532
type: UnificationXref
id: F8W4A6
db: uniprot

uniprot F7EZU0 522
type: UnificationXref
id: F7EZU0
db: uniprot

Transforming growth factor beta-1 proprotein
type: ProteinReference
xref: uniprot P17246 595
xref: PTHR11848:SF125
organism: Rattus norvegicus

Nodal growth differentiation factor
type: ProteinReference
xref: PTHR11848:SF159
xref: uniprot D3ZGK9 464
organism: Rattus norvegicus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q16539 40
organism: Homo sapiens

uniprot F7EDR2 145
type: UnificationXref
id: F7EDR2
db: uniprot

Ras-GDP
type: ProteinReference
xref: P01291
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=TGF-beta signaling pathway.PROTEIN.GENERIC.Ras-GDP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ras-like protein rasS
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: GTPase HRas
member entity reference: RAS related 2
member entity reference: Uncharacterized protein rasC
member entity reference: Protein CBR-LET-60
member entity reference: Protein CBR-CDC-42
member entity reference: GTPase NRas
member entity reference: Uncharacterized protein
member entity reference: Ras-like protein rasG
member entity reference: Ras-like protein 1
member entity reference: GTPase HRas isoform 1
member entity reference: NRAS protein
member entity reference: Protein CBR-RAB-10
member entity reference: Ras-related protein R-Ras
member entity reference: Uncharacterized protein rasS
member entity reference: Ras-related protein Rab-10
member entity reference: RAS related
member entity reference: Ras-like protein
member entity reference: Ras-like protein rasC
member entity reference: Ras protein let-60
member entity reference: Predicted protein
member entity reference: Protein CBR-RAS-1
member entity reference: GTP-binding protein Rheb homolog 1
member entity reference: AGAP002219-PA
member entity reference: GTPase KRas
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: Ras-like protein rasB
member entity reference: Uncharacterized protein rasB
member entity reference: HRAS isoform 2
member entity reference: Related RAS viral (R-ras) oncogene homolog
member entity reference: RAS-related 2
member entity reference: GTP binding protein
member entity reference: Ras-like protein 2
member entity reference: Uncharacterized protein rasG
member entity reference: Ras family GTPase
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: NRAS isoform 1
member entity reference: Protein ras-1
member entity reference: Uncharacterized protein rasD
member entity reference: Ras-like protein rasD
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: HRas proto-oncogene, GTPase a

PTHR13808:SF28
type: RelationshipXref
id: PTHR13808:SF28
db: PANTHER Family
relationship type: By Homology

PTHR13808:SF29
type: RelationshipXref
id: PTHR13808:SF29
db: PANTHER Family
relationship type: By Homology

Cbp/p300-interacting transactivator 3
type: ProteinReference
xref: uniprot Q9I8K7 391
xref: PTHR17045:SF5
organism: Gallus gallus

Serine/threonine-protein kinase sma-6
type: ProteinReference
xref: PTHR23255:SF68
xref: uniprot Q09488 106
organism: Caenorhabditis elegans

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: uniprot Q5A1D3 870
organism: Candida albicans

Bone morphogenetic protein receptor type-1B
type: ProteinReference
xref: PTHR23255:SF62
xref: uniprot O00238 156
organism: Homo sapiens

I-SMAD
type: DnaRegion
entity reference: I-SMAD
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot E2R6T4 310
organism: Canis lupus familiaris

Mothers against decapentaplegic homolog
type: DnaReference
xref: PTHR13703:SF44
organism: Bos taurus

Growth/differentiation factor 10
type: ProteinReference
xref: uniprot P55107 631
xref: PTHR11848:SF145
organism: Homo sapiens

Mothers against decapentaplegic homolog
type: DnaReference
xref: PTHR13703:SF28
organism: Bos taurus

uniprot P43027 619
type: UnificationXref
id: P43027
db: uniprot

Growth/differentiation factor 10
type: ProteinReference
xref: PTHR11848:SF145
xref: uniprot P55108 632
organism: Rattus norvegicus

uniprot Q66KL4 659
type: UnificationXref
id: Q66KL4
db: uniprot

uniprot Q9FXT7 878
type: UnificationXref
id: Q9FXT7
db: uniprot

Activating transcription factor 2
type: ProteinReference
xref: uniprot F1PCQ4 318
xref: PTHR19304:SF9
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras_GDP-RIGHT__Ras_GTP-_r18
controller: Complex (TGFbetareceptor I/TGFbetareceptor II/ TGF_beta)

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 845

uniprot H2R5I7 561
type: UnificationXref
id: H2R5I7
db: uniprot

uniprot Q9FWQ5 389
type: UnificationXref
id: Q9FWQ5
db: uniprot

uniprot Q1HL14 650
type: UnificationXref
id: Q1HL14
db: uniprot

PTHR13808:SF43
type: RelationshipXref
id: PTHR13808:SF43
db: PANTHER Family
relationship type: By Homology

Peptidyl-prolyl cis-trans isomerase
type: ProteinReference
xref: uniprot Q9RTC6 753
organism: Deinococcus radiodurans

uniprot Q9WUI1 52
type: UnificationXref
id: Q9WUI1
db: uniprot

uniprot H2QVU7 558
type: UnificationXref
id: H2QVU7
db: uniprot

SMAD specific E3 ubiquitin protein ligase 2
type: ProteinReference
xref: uniprot F1NJU6 191
xref: PTHR11254:SF300
organism: Gallus gallus

uniprot Q8W4D8 378
type: UnificationXref
id: Q8W4D8
db: uniprot

PTHR11462:SF35
type: RelationshipXref
id: PTHR11462:SF35
db: PANTHER Family
relationship type: By Homology

uniprot P28482 858
type: UnificationXref
id: P28482
db: uniprot

PTHR10005:SF15
type: RelationshipXref
id: PTHR10005:SF15
db: PANTHER Family
relationship type: By Homology

uniprot F1PXS7 843
type: UnificationXref
id: F1PXS7
db: uniprot

RCG59826
type: ProteinReference
xref: uniprot A0A0U1RRU5 772
xref: PTHR13832:SF533
organism: Rattus norvegicus

Inhibin beta C chain
type: ProteinReference
xref: PTHR11848:SF130
xref: uniprot P55104 629
organism: Mus musculus

Bone morphogenetic protein 8B
type: ProteinReference
xref: PTHR11848:SF132
xref: uniprot P55105 630
organism: Mus musculus

Inhibin beta C chain
type: ProteinReference
xref: uniprot P55103 628
xref: PTHR11848:SF130
organism: Homo sapiens

PTHR11462:SF37
type: RelationshipXref
id: PTHR11462:SF37
db: PANTHER Family
relationship type: By Homology