Non-specific serine/threonine protein kinase
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.TCR_br_zeta
Phosphatidylinositol 3-kinase catalytic subunit type 3
SOS Ras/Rac guanine nucleotide exchange factor 1
Dual specificity mitogen-activated protein kinase kinase 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Dual-specificity mitogen-activated protein kinase kinase 2
ENTITY_REFERENCE_NOTES= Long Name: Calmodulin Synonym: Synonym not specified Accession: P01305
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Calmodulin
Inhibitor of nuclear factor kappa B kinase subunit beta
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
Phosphatidylinositol 3-kinase regulatory subunit gamma
A-Raf proto-oncogene, serine/threonine kinase
Conserved helix-loop-helix ubiquitous kinase
T-cell surface glycoprotein CD3 gamma chain
Inositol 1,4,5-trisphosphate receptor type 1
T-cell surface glycoprotein CD3 delta chain
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Cell division control protein 42 homolog isoform 2
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.CD45
ENTITY_REFERENCE_NOTES= Long Name: CD45 Synonym: Leukocyte common antigen Accession: P01329
T-cell-specific surface glycoprotein CD28 homolog
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Ras-related C3 botulinum toxin substrate 1
T-cell-specific surface glycoprotein CD28
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.PLC-gamma
ENTITY_REFERENCE_NOTES= Long Name: PLC-gamma Synonym: phospholipase c, gamma isoform Accession: P01320
Vav guanine nucleotide exchange factor 1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Inhibitor of nuclear factor kappa-B kinase subunit beta
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.cdc42
ENTITY_REFERENCE_NOTES= Long Name: MEKK Synonym: MAP kinase kinase kinase,MEK kinase Accession: P01297
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.MEKK
B-Raf proto-oncogene, serine/threonine kinase
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.fos
ENTITY_REFERENCE_NOTES= Long Name: fos Synonym: c-fos Accession: P01309
Raf-1 proto-oncogene, serine/threonine kinase
ENTITY_REFERENCE_NOTES= Long Name: PKC theta Synonym: Protein Kinase C theta Accession: P01318
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.PKC-theta
Mitogen-activated protein kinase kinase kinase 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
T-cell surface glycoprotein CD3 zeta chain
Vav guanine nucleotide exchange factor 3
Ras-related C3 botulinum toxin substrate
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.rac
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Gads
Inhibitor of nuclear factor kappa-B kinase subunit alpha
ENTITY_REFERENCE_NOTES= Long Name: MEK Synonym: MAPK/ERK kinase Accession: P01312
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.MEK
-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Phosphatidylinositol 3-kinase regulatory subunit beta
Phosphatidylinositol 3-kinase regulatory subunit alpha
Dual specificity mitogen-activated protein kinase kinase 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
SOS Ras/Rho guanine nucleotide exchange factor 2
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
ENTITY_REFERENCE_NOTES= Long Name: Raf Synonym: Synonym not specified Accession: P01311
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Raf
Mitogen-activated protein kinase kinase 1
RAC-gamma serine/threonine-protein kinase
Linker for activation of T-cells family member 1
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Grb2
Cell division control protein 42 homolog
T-cell surface glycoprotein CD3 epsilon chain
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
RAC-alpha serine/threonine-protein kinase
RAC-beta serine/threonine-protein kinase
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.CD3_br_gamma
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.B7
ENTITY_REFERENCE_NOTES= Long Name: B7 Synonym: Synonym not specified Accession: P01337
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.SLP-76
Complex (TCR Beta/MHC-antigen/ CD3 gamma/TCR alpha/ CD3 eta/CD3 delta/ TCR zeta)
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Calcineurin
ENTITY_REFERENCE_NOTES= Long Name: Calcineurin Synonym: Synonym not specified Accession: P01315
ENTITY_REFERENCE_NOTES= Long Name: CD28 Synonym: Synonym not specified Accession: P01313
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.CD28
Complex (LAT/SLP-76/ Grb2/SOS/ Gads/PLC-gamma)
RAF proto-oncogene serine/threonine-protein kinase
Mitogen-activated protein kinase kinase 2
Harvey rat sarcoma viral oncogene homolog
ENTITY_REFERENCE_NOTES= Long Name: I kappa B Synonym: IkB,inhibitor of NF-kappa B Accession: P01323
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.I kappa B
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Phosphoinositide-3-kinase regulatory subunit 1
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.CD3_br_eta
MODEL_NOTES=Panther Pathway: P00053 T cell activation refers to a process in which mature T cells, which express antigen-specific T cell receptors on their surfaces, recognize their cognate antigens and respond by entering the cell cycle, secreting cytokines or lytic enzymes, and initiating the cell-based functions of the immune system. T cell signaling involves a complex network of biochemical interactions, most of which are initiated downstream of the TCR itself, but a few of which can be induced by accessory receptors. TCR signaling requires close interactions between the T cell and an antigen presenting cell, and as a result involve extensive coordination between TCR signaling networks and both cytoskeletal and membrane dynamic processes. Medline=10781399 Medline=10781404 Medline=15001169 PMID: 10781399 PMID: 10781404 PMID: 15001169
ENTITY_REFERENCE_NOTES= Long Name: jun Synonym: Synonym not specified Accession: P01335
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.jun
ENTITY_REFERENCE_NOTES= Long Name: Lck Synonym: Lymphocyte-specific c-src family protein tyrosine kinase Accession: P01310
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Lck
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.ION_CHANNEL.IP3R
ENTITY_REFERENCE_NOTES= Long Name: IP3R Synonym: IP3 Receptor Accession: P01331
Phosphoinositide-3-kinase regulatory subunit 3
Complex (CD3 gamma/TCR alpha/ TCR Beta/CD3 delta/ CD3 eta/TCR zeta)
ENTITY_REFERENCE_NOTES= Long Name: IKK Synonym: Inhibitor of NF-kappa B kinase Accession: P01330
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.IKK
ENTITY_REFERENCE_NOTES= Long Name: Akt Synonym: PKB,Protein Kinase B Accession: P01332
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Akt
Guanine nucleotide exchange factor VAV2 isoform 1
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.SOS
Phosphoinositide-3-kinase regulatory subunit 2
Receptor-type tyrosine-protein phosphatase C
ENTITY_REFERENCE_NOTES= Long Name: vav Synonym: Synonym not specified Accession: P01295
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.vav
CD3 antigen, zeta polypeptide, isoform CRA_b
ENTITY_REFERENCE_NOTES= Long Name: Pak Synonym: p21-activated kinase Accession: P01319
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Pak
Complex (CD3 gamma/TCR Beta/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)
ENTITY_REFERENCE_NOTES= Long Name: WASP Synonym: Wiscott-Aldrich Syndrome Protein Accession: P01334
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.WASP
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.ZAP-70
ENTITY_REFERENCE_NOTES= Long Name: ZAP-70 Synonym: Zeta-associated protein of 70 kD Accession: P01308
ENTITY_REFERENCE_NOTES= Long Name: PI3K Synonym: Phosphatidyl Inositol (3,4,5) kinase Accession: P01322
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.PI3K
Proto-oncogene tyrosine-protein kinase LCK
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.RECEPTOR.TCR_br_Beta
ENTITY_REFERENCE_NOTES= Long Name: Jnk Synonym: Jun kinase,c-Jun N-terminal Kinase Accession: P01336
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Jnk
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.CD3_br_delta
Fos proto-oncogene, AP-1 transcription factor subunit
ENTITY_REFERENCE_NOTES= Long Name: nck Synonym: Synonym not specified Accession: P01314
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.nck
Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Ras
Complex (TCR Beta/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)
Complex (TCR Beta/MHC-antigen/ TCR alpha/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta)
Vav guanine nucleotide exchange factor 2
Ras-related C3 botulinum toxin substrate 2
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Csk
ENTITY_REFERENCE_NOTES= Long Name: Csk Synonym: c-src kinase Accession: P01304
ENTITY_REFERENCE_NOTES= Long Name: ERK Synonym: Estrogen Regulated Kinase Accession: P01300
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.ERK
ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.LAT
ENTITY_REFERENCE_NOTES= Long Name: LAT Synonym: Linker for Activation of T cells,pp36/38 Accession: P01325
Complex (LAT/Pak/ Gads/SLP-76/ WASP/vav/ nck)
Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1