Calmodulin
type: ProteinReference
xref: uniprot P62152 140
organism: Drosophila melanogaster

uniprot Q66JE6 248
type: UnificationXref
id: Q66JE6
db: uniprot

uniprot F1N7C3 170
type: UnificationXref
id: F1N7C3
db: uniprot

y CD3 gamma s47 sa48 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 gamma s47 sa48 rs2 y
comment: MODIFICATION_RESIDUE_ANGLE=2.42102100526642
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot E1BS97 309
organism: Gallus gallus

uniprot H2QNG6 386
type: UnificationXref
id: H2QNG6
db: uniprot

Calmodulin
type: ProteinReference
xref: PTHR23050:SF424
xref: uniprot P62149 139
organism: Gallus gallus

TCR zeta
type: ProteinReference
xref: P01296
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.TCR_br_zeta
comment: ENTITY_REFERENCE_NOTES=
member entity reference: CD247 molecule
member entity reference: CD247 isoform 2
member entity reference: T-cell surface glycoprotein CD3 zeta chain
member entity reference: Uncharacterized protein
member entity reference: CD3 antigen, zeta polypeptide, isoform CRA_b

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6SZ66 369
xref: PTHR10048:SF7
organism: Monodelphis domestica

uniprot P01101 199
type: UnificationXref
id: P01101
db: uniprot

PARTICIPANT STOICHIOMETRY r111 817
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

CD3 gamma
type: Protein
entity reference: CD3 gamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa48 739
feature: y CD3 gamma s47 sa48 rs1
feature: y CD3 gamma s47 sa48 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r111 819
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r111 818
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A452DI16 213
xref: PTHR44329:SF55
organism: Bos taurus

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

Y ERK s236 a379 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ERK s236 a379 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=-0.0

Y171 LAT s406 a275 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y171
feature location: Y171 LAT s406 a275 rs3 Y171
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7720410517750427
comment: MODIFICATION_RESIDUE_NAME=Y171

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot H2QIH7 268
organism: Pan troglodytes

Complex (Calmodulin/Ca++/ Ca++)
type: Complex
component stoichiometry: Calmodulin s86 sa87 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca PLUS PLUS s87 sa88 STOICHIOMETRY ID COMPLEX
component: Ca++
component: Calmodulin
feature: COMPLEX BINDING FEATURE s451 a699 658
feature: COMPLEX BINDING FEATURE s451 a699 660
cellular location: cytosol

Calmodulin
type: ProteinReference
xref: PTHR23050:SF381
xref: uniprot P62157 142
organism: Bos taurus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 32

Uncharacterized protein
type: ProteinReference
xref: PTHR45818:SF1
xref: uniprot F7BD31 22
organism: Macaca mulatta

uniprot F1Q4F8 478
type: UnificationXref
id: F1Q4F8
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P28482 71
xref: PTHR24055:SF203
organism: Homo sapiens

Ras
type: Protein
entity reference: Ras
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 717
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q4V7G0 43
type: UnificationXref
id: Q4V7G0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 61
organism: Canis lupus familiaris

uniprot F6ZKB3 513
type: UnificationXref
id: F6ZKB3
db: uniprot

PARTICIPANT STOICHIOMETRY r88 868
type: Stoichiometry
physical entity: Complex (CD28/B7)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r88 866
type: Stoichiometry
physical entity: Complex (CD28/B7)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r88 867
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r88 865
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q8WNW7 419
type: UnificationXref
id: Q8WNW7
db: uniprot

uniprot P47197 491
type: UnificationXref
id: P47197
db: uniprot

uniprot A0A1D5NVQ5 6
type: UnificationXref
id: A0A1D5NVQ5
db: uniprot

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q8NEB9 410
xref: PTHR10048:SF7
organism: Homo sapiens

uniprot Q8CFN2 501
type: UnificationXref
id: Q8CFN2
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1Q118 172
xref: PTHR23113:SF168
organism: Canis lupus familiaris

NF AT s300 a495 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=-0.0

uniprot F7GRP2 93
type: UnificationXref
id: F7GRP2
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P27361 70
xref: PTHR24055:SF393
organism: Homo sapiens

uniprot A0A2I3SD30 277
type: UnificationXref
id: A0A2I3SD30
db: uniprot

GTP s113 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

GTP s20 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

SLP 76 s77 sa75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SLP-76
stoichiometric coefficient: 1.0

ncbitaxon 44689 133
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot P04234 438
type: UnificationXref
id: P04234
db: uniprot

y CD3 gamma s47 sa48 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 gamma s47 sa48 rs1 y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=3.784784172784049

uniprot F7D7P2 127
type: UnificationXref
id: F7D7P2
db: uniprot

uniprot P60766 497
type: UnificationXref
id: P60766
db: uniprot

NRAS protein
type: ProteinReference
xref: uniprot A5D7R9 154
xref: PTHR24070:SF189
organism: Bos taurus

Y CD28 s35 sa36 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y CD28 s35 sa36 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CD3 eta
type: Protein
entity reference: CD3 eta
feature: y CD3 eta s49 sa50 rs2
feature: y CD3 eta s49 sa50 rs1

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q01986 242
xref: PTHR48013:SF5
organism: Rattus norvegicus

Calmodulin
type: ProteinReference
xref: uniprot E9H5Z2 120
organism: Daphnia pulex

uniprot A0A3S5ZP81 524
type: UnificationXref
id: A0A3S5ZP81
db: uniprot

uniprot P43404 191
type: UnificationXref
id: P43404
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r68
controller: Complex (DAG/PKC-theta)

uniprot E1BE66 360
type: UnificationXref
id: E1BE66
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q9Z1L0 413
xref: PTHR10048:SF33
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__jun-_ATP-RIGHT__jun-_ADP-_r52
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 891
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 889
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 890
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 892
left: ATP
left: jun
interaction type: STATE_TRANSITION
right: ADP
right: jun

Protein CBR-CMD-1
type: ProteinReference
xref: uniprot A8WPJ8 104
organism: Caenorhabditis briggsae

Y TCR zeta s58 sa59 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s58 sa59 rs6 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=4.644304929068502

PTHR19969:SF12
type: RelationshipXref
id: PTHR19969:SF12
db: PANTHER Family
relationship type: By Homology

PTHR19969:SF16
type: RelationshipXref
id: PTHR19969:SF16
db: PANTHER Family
relationship type: By Homology

uniprot Q07889 183
type: UnificationXref
id: Q07889
db: uniprot

NF-kappa B
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

nck
type: Protein
entity reference: nck
feature: COMPLEX PARTICIPANT BINDING FEATURE s108 sa112 545
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F1NYZ2 234
organism: Gallus gallus

Rac family small GTPase 3a
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot Q6DGB7 428
organism: Danio rerio

Calmodulin
type: ProteinReference
xref: P01305
comment: ENTITY_REFERENCE_NOTES= Long Name: Calmodulin Synonym: Synonym not specified Accession: P01305
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Calmodulin
member entity reference: Uncharacterized protein
member entity reference: Calmodulin-1
member entity reference: Predicted protein
member entity reference: Calmodulin 1
member entity reference: Calmodulin
member entity reference: Protein CBR-CMD-1
member entity reference: Putative calmodulin
member entity reference: AGAP010957-PA (Fragment)
member entity reference: Predicted protein (Fragment)
member entity reference: Calmodulin-2
member entity reference: Calmodulin-7
member entity reference: Calmodulin-3

Y TCR zeta s58 sa59 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s58 sa59 rs5 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.278337656950498
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot E2RGT8 18
type: UnificationXref
id: E2RGT8
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF2
xref: uniprot A5D7T5 278
organism: Bos taurus

uniprot Q64159 299
type: UnificationXref
id: Q64159
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot E2RPB0 364
organism: Canis lupus familiaris

cdc42 s10 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cdc42
stoichiometric coefficient: 1.0

uniprot A9SHH7 108
type: UnificationXref
id: A9SHH7
db: uniprot

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: uniprot F1PHV7 155
xref: PTHR24070:SF189
organism: Canis lupus familiaris

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot E2RKR0 450
organism: Canis lupus familiaris

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q2TY19 509
organism: Gallus gallus

uniprot P28482 71
type: UnificationXref
id: P28482
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E7EXT6 475
xref: PTHR24356:SF190
organism: Danio rerio

NRAS isoform 1
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot H2PZQ7 158
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__LAT-RIGHT__LAT-_r16
controller: Complex (CD3 gamma/TCR Beta/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7DUD6 376
organism: Ornithorhynchus anatinus

Y132 LAT s89 sa90 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y132
feature location: Y132 LAT s89 sa90 rs2 Y132
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3298847729394225
comment: MODIFICATION_RESIDUE_NAME=Y132

Gads s80 sa78 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gads
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q64143 407
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7CU42 318
xref: PTHR48015:SF22
organism: Monodelphis domestica

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 480
organism: Monodelphis domestica

uniprot C3YJC1 422
type: UnificationXref
id: C3YJC1
db: uniprot

ncbitaxon 10090 32
type: UnificationXref
id: 10090
db: ncbitaxon

T cell proliferation
type: Pathway

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot E2RL20 215
xref: PTHR44329:SF55
organism: Canis lupus familiaris

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q63844 74
xref: PTHR24055:SF393
organism: Mus musculus

uniprot H2QF58 26
type: UnificationXref
id: H2QF58
db: uniprot

uniprot Q62245 185
type: UnificationXref
id: Q62245
db: uniprot

NF-AT
type: Protein
feature: NF AT s300 a495 rs1
feature: ACTIVE 5
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot G3V926 454
organism: Rattus norvegicus

T-cell surface glycoprotein CD3 gamma chain
type: ProteinReference
xref: PTHR10570:SF8
xref: uniprot Q64159 299
organism: Rattus norvegicus

uniprot A5A6H2 193
type: UnificationXref
id: A5A6H2
db: uniprot

Y505 Lck s499 a653 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y505
feature location: Y505 Lck s499 a653 rs2 Y505
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y505
comment: MODIFICATION_RESIDUE_ANGLE=3.15

uniprot F1P4Q4 263
type: UnificationXref
id: F1P4Q4
db: uniprot

NF-AT
type: Protein
feature: NF AT s297 a494 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r46 771
type: Stoichiometry
physical entity: CRAC
stoichiometric coefficient: 1.0

Complex (CD28/B7)
type: Complex
component stoichiometry: B7 s38 sa39 STOICHIOMETRY ID COMPLEX
component: B7
component: CD28
feature: COMPLEX BINDING FEATURE s344 a579 666
feature: COMPLEX BINDING FEATURE s344 a579 668
cellular location: cytosol

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A2I3SSC7 463
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r46 772
type: Stoichiometry
physical entity: CRAC
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E1C3P6 310
xref: PTHR48015:SF20
organism: Gallus gallus

STATE_TRANSITION_LEFT__CRAC-RIGHT__CRAC-_r46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 771
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 772
left: CRAC
interaction type: STATE_TRANSITION
right: CRAC

Actin polymerization
type: Pathway

HETERODIMER_ASSOCIATION_LEFT__PIP3-_Akt-RIGHT__Complex__PIP3_Akt_-_r112
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 812
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 811
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 813
left: PIP3
left: Akt
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PIP3/Akt)

nck s108 sa112 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: nck
stoichiometric coefficient: 1.0

uniprot O00329 388
type: UnificationXref
id: O00329
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F7BWW9 177
organism: Ornithorhynchus anatinus

GDP s11 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

MODULATION
type: RelationshipTypeVocabulary

CD3 eta
type: Protein
entity reference: CD3 eta
feature: y CD3 eta s43 sa44 rs2
feature: y CD3 eta s43 sa44 rs1

T-cell surface glycoprotein CD3 delta chain
type: ProteinReference
xref: PTHR10570:SF5
xref: uniprot P04234 438
organism: Homo sapiens

T-cell surface glycoprotein CD3 delta chain
type: ProteinReference
xref: PTHR10570:SF5
xref: uniprot P04235 439
organism: Mus musculus

PTHR46037:SF3
type: RelationshipXref
id: PTHR46037:SF3
db: PANTHER Family
relationship type: By Homology

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

eco ECO:0000353 182
type: UnificationXref
id: ECO:0000353
db: eco

uniprot A0A3Q1NH21 472
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

Uncharacterized protein
type: ProteinReference
xref: uniprot J9NXY2 129
xref: PTHR23050:SF383
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot Q62077 340
organism: Mus musculus

CD28 s35 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD28
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UBN4 296
organism: Gallus gallus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2RA86 68
xref: PTHR24055:SF393
organism: Pan troglodytes

TCR alpha s48 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR alpha
stoichiometric coefficient: 1.0

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot Q60631 89
xref: PTHR46037:SF4
organism: Mus musculus

uniprot A0A1D5QUZ8 58
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

Y TCR zeta s44 sa45 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s44 sa45 rs1 Y
comment: MODIFICATION_RESIDUE_ANGLE=0.7443253848069942
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

MEK
type: Protein
entity reference: MEK
feature: MEK s415 a400 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot G7MGQ5 383
xref: PTHR10155:SF2
organism: Macaca mulatta

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 107

SLP 76 s68 sa100 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SLP-76
stoichiometric coefficient: 1.0

uniprot Q0VD16 244
type: UnificationXref
id: Q0VD16
db: uniprot

Complex (Ras/GTP)
type: Complex
component stoichiometry: Ras s6 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s7 sa6 STOICHIOMETRY ID COMPLEX
component: Ras
component: GTP
feature: COMPLEX BINDING FEATURE s243 a389 716
feature: COMPLEX BINDING FEATURE s243 a389 718
cellular location: cytosol

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6X434 285
xref: PTHR45673:SF2
organism: Ornithorhynchus anatinus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__jun-_ATP-RIGHT__jun-_ADP-_r52
controller: Jnk

VAV2 isoform 2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot A0A2I3T4A4 10
organism: Pan troglodytes

PTHR15586:SF0
type: RelationshipXref
id: PTHR15586:SF0
db: PANTHER Family
relationship type: By Homology

SLP-76
type: Protein
entity reference: SLP-76
feature: Y SLP 76 s92 sa93 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa93 613
feature: Y SLP 76 s92 sa93 rs3
feature: Y SLP 76 s92 sa93 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

LAT s76 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LAT
stoichiometric coefficient: 1.0

uniprot P35465 324
type: UnificationXref
id: P35465
db: uniprot

uniprot Q8BTI9 409
type: UnificationXref
id: Q8BTI9
db: uniprot

Cell division control protein 42 homolog isoform 2
type: ProteinReference
xref: PTHR24072:SF337
xref: uniprot F6RBZ7 495
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

LAT s93 sa94 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LAT
stoichiometric coefficient: 1.0

uniprot Q4QHT2 145
type: UnificationXref
id: Q4QHT2
db: uniprot

uniprot D3ZYG0 14
type: UnificationXref
id: D3ZYG0
db: uniprot

PTHR48015:SF30
type: RelationshipXref
id: PTHR48015:SF30
db: PANTHER Family
relationship type: By Homology

CD45
type: ProteinReference
xref: P01329
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.CD45
comment: ENTITY_REFERENCE_NOTES= Long Name: CD45 Synonym: Leukocyte common antigen Accession: P01329
member entity reference: PTPRC isoform 2
member entity reference: Receptor-type tyrosine-protein phosphatase C
member entity reference: Uncharacterized protein

Calmodulin
type: ProteinReference
xref: uniprot E3KLJ3 118
organism: Puccinia graminis

HETERODIMER_ASSOCIATION_LEFT__PIP2-_Akt-RIGHT__Complex__PIP2_Akt_-_r83
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 895
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 893
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 894
left: PIP2
left: Akt
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PIP2/Akt)

uniprot E2R2N2 60
type: UnificationXref
id: E2R2N2
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A9V8J8 109
organism: Monosiga brevicollis

PTHR44329:SF55
type: RelationshipXref
id: PTHR44329:SF55
db: PANTHER Family
relationship type: By Homology

uniprot Q13153 326
type: UnificationXref
id: Q13153
db: uniprot

rac
type: Protein
entity reference: rac
feature: COMPLEX PARTICIPANT BINDING FEATURE s112 sa12 561
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q62077 340
type: UnificationXref
id: Q62077
db: uniprot

TCR zeta
type: Protein
entity reference: TCR zeta
feature: Y TCR zeta s51 sa52 rs3
feature: Y TCR zeta s51 sa52 rs5
feature: Y TCR zeta s51 sa52 rs4
feature: Y TCR zeta s51 sa52 rs6
feature: Y TCR zeta s51 sa52 rs1
feature: Y TCR zeta s51 sa52 rs2

SLP 76 s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SLP-76
stoichiometric coefficient: 1.0

uniprot G3V926 454
type: UnificationXref
id: G3V926
db: uniprot

uniprot Q60823 492
type: UnificationXref
id: Q60823
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF407
xref: uniprot F7GRP2 93
organism: Macaca mulatta

T-cell-specific surface glycoprotein CD28 homolog
type: ProteinReference
xref: PTHR11494:SF7
xref: uniprot A0A452J7W4 250
organism: Gallus gallus

CD45
type: Protein
entity reference: CD45

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XT65 236
xref: PTHR48013:SF5
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot H2QS62 515
organism: Pan troglodytes

B7 s36 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: B7
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P20651 288
xref: PTHR45673:SF7
organism: Rattus norvegicus

PTHR44329:SF47
type: RelationshipXref
id: PTHR44329:SF47
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__CD45-RIGHT__CD45-_r97
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 821
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 820
left: CD45
interaction type: STATE_TRANSITION
right: CD45

Wiskott-Aldrich syndrome protein
type: ProteinReference
xref: PTHR23202:SF3
xref: uniprot H9ZD75 502
organism: Macaca mulatta

fos s26 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: fos
stoichiometric coefficient: 1.0

uniprot D3ZVW0 55
type: UnificationXref
id: D3ZVW0
db: uniprot

Calmodulin-7
type: ProteinReference
xref: uniprot P59220 137
xref: PTHR23050:SF438
organism: Arabidopsis thaliana

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7G800 319
xref: PTHR48015:SF30
organism: Monodelphis domestica

Y TCR zeta s44 sa45 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s44 sa45 rs4 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=5.77761058581875

Y191 LAT s93 sa94 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y191
feature location: Y191 LAT s93 sa94 rs4 Y191
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y191
comment: MODIFICATION_RESIDUE_ANGLE=5.800300360425278

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q5RKN6 88
organism: Danio rerio

nck
type: Protein
entity reference: nck
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot F6Q932 283
organism: Macaca mulatta

uniprot D3ZFJ0 358
type: UnificationXref
id: D3ZFJ0
db: uniprot

PTHR22969:SF7
type: RelationshipXref
id: PTHR22969:SF7
db: PANTHER Family
relationship type: By Homology

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: uniprot H2QW34 455
xref: PTHR22969:SF7
organism: Pan troglodytes

Y110 LAT s4 a4 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y110
feature location: Y110 LAT s4 a4 rs1 Y110
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y110
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

uniprot P42768 503
type: UnificationXref
id: P42768
db: uniprot

PTHR10155:SF3
type: RelationshipXref
id: PTHR10155:SF3
db: PANTHER Family
relationship type: By Homology

uniprot P31751 489
type: UnificationXref
id: P31751
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot A0A3Q2U4X3 473
organism: Gallus gallus

CD86 isoform 3
type: ProteinReference
xref: uniprot H2QN76 528
xref: PTHR25466:SF2
organism: Pan troglodytes

uniprot A0A2I3T7A8 353
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

Y TCR zeta s44 sa45 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s44 sa45 rs5 Y
comment: MODIFICATION_RESIDUE_ANGLE=5.278337656950498
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

PTHR10155:SF2
type: RelationshipXref
id: PTHR10155:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF1
type: RelationshipXref
id: PTHR10155:SF1
db: PANTHER Family
relationship type: By Homology

Y171 LAT s97 sa101 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y171
feature location: Y171 LAT s97 sa101 rs3 Y171
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7720410517750427
comment: MODIFICATION_RESIDUE_NAME=Y171

Complex (cdc42/GDP)
type: Complex
component stoichiometry: cdc42 s10 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s11 sa15 STOICHIOMETRY ID COMPLEX
component: cdc42
component: GDP
feature: COMPLEX BINDING FEATURE s267 a436 750
feature: COMPLEX BINDING FEATURE s267 a436 748
cellular location: cytosol

vav
type: Protein
entity reference: vav
feature: COMPLEX PARTICIPANT BINDING FEATURE s107 sa111 543
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__Complex__SOS_Grb2_-_LAT-_Complex__Gads_SLP_76_-_PLC_gamma-RIGHT__Complex__LAT_SLP_76__Grb2_SOS__Gads_PLC_gamma_-_r100
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 877
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 878
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 876
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 879
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 875
left: Complex (Gads/SLP-76)
left: LAT
left: PLC-gamma
left: Complex (SOS/Grb2)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (LAT/SLP-76/ Grb2/SOS/ Gads/PLC-gamma)

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

MEKK
type: Protein
entity reference: MEKK
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__MEKK-RIGHT__MEKK-_re61
controller: Complex (rac/GTP)

uniprot F6URW3 174
type: UnificationXref
id: F6URW3
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P19174 339
xref: PTHR10336:SF173
organism: Homo sapiens

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6RUV5 431
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A1D5QE27 350
xref: PTHR10048:SF7
organism: Macaca mulatta

CD45
type: Protein
entity reference: CD45
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

jun s25 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: jun
stoichiometric coefficient: 1.0

uniprot O70601 435
type: UnificationXref
id: O70601
db: uniprot

ZAP 70 s507 sa72 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ZAP-70
stoichiometric coefficient: 1.0

Y TCR zeta s44 sa45 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s44 sa45 rs2 Y
comment: MODIFICATION_RESIDUE_ANGLE=0.3576366636899095
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot F6T2A6 123
type: UnificationXref
id: F6T2A6
db: uniprot

uniprot A0A2I3S4L7 341
type: UnificationXref
id: A0A2I3S4L7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K5T3 349
organism: Rattus norvegicus

uniprot K7AWV1 94
type: UnificationXref
id: K7AWV1
db: uniprot

ncbitaxon 7165 150
type: UnificationXref
id: 7165
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r110 823
type: Stoichiometry
physical entity: Complex (LAT/Gads/ SLP-76)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r110 822
type: Stoichiometry
physical entity: Complex (LAT/PLC-gamma/ Gads/SLP-76)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r110 824
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

CD45 s386 a632 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD45
stoichiometric coefficient: 2.0

Y TCR zeta s44 sa45 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s44 sa45 rs3 Y
comment: MODIFICATION_RESIDUE_ANGLE=6.2116579744416045
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Complex (cdc42/GTP/ WASP)
type: Complex
component stoichiometry: cdc42 s14 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s15 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: WASP s16 sa20 STOICHIOMETRY ID COMPLEX
component: WASP
component: GTP
component: cdc42
feature: COMPLEX BINDING FEATURE s269 a452 570
feature: COMPLEX BINDING FEATURE s269 a452 568
feature: COMPLEX BINDING FEATURE s269 a452 572
cellular location: cytosol

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EI48 65
xref: PTHR24055:SF393
organism: Monodelphis domestica

Rac family small GTPase 1b
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q29RC5 426
organism: Danio rerio

uniprot A0A3Q1M0G8 308
type: UnificationXref
id: A0A3Q1M0G8
db: uniprot

uniprot Q8CIN4 332
type: UnificationXref
id: Q8CIN4
db: uniprot

T-cell-specific surface glycoprotein CD28
type: ProteinReference
xref: uniprot P31041 253
xref: PTHR11494:SF7
organism: Mus musculus

T-cell-specific surface glycoprotein CD28
type: ProteinReference
xref: PTHR11494:SF7
xref: uniprot P31042 254
organism: Rattus norvegicus

TRANSPORT_LEFT__ERK-RIGHT__ERK-_r94
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 832
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 833
left: ERK
interaction type: TRANSPORT
right: ERK

Cytoplasmic protein NCK2
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot O55033 270
organism: Mus musculus

Y226 LAT s66 sa98 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y226
feature location: Y226 LAT s66 sa98 rs5 Y226
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.5851730116547973
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y226

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7GEK1 484
xref: PTHR24356:SF190
organism: Monodelphis domestica

PLC-gamma
type: ProteinReference
xref: P01320
standard name: Phospholipase C gamma
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.PLC-gamma
comment: ENTITY_REFERENCE_NOTES= Long Name: PLC-gamma Synonym: phospholipase c, gamma isoform Accession: P01320
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

PARTICIPANT STOICHIOMETRY r25 856
type: Stoichiometry
physical entity: Complex (Ras/GTP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 857
type: Stoichiometry
physical entity: Complex (Ras/GTP/ Raf)
stoichiometric coefficient: 1.0

uniprot A0A2I3RSP9 276
type: UnificationXref
id: A0A2I3RSP9
db: uniprot

PARTICIPANT STOICHIOMETRY r25 855
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

TRANSPORT
type: RelationshipTypeVocabulary

Ras
type: Protein
entity reference: Ras
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 693
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E2RJ59 281
type: UnificationXref
id: E2RJ59
db: uniprot

uniprot P04157 446
type: UnificationXref
id: P04157
db: uniprot

uniprot Q9JHG7 412
type: UnificationXref
id: Q9JHG7
db: uniprot

Vav guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR45818:SF2
xref: uniprot E2RGT8 18
organism: Canis lupus familiaris

uniprot Q0PDN4 255
type: UnificationXref
id: Q0PDN4
db: uniprot

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 50

Lck
type: Protein
entity reference: Lck
feature: Y394 Lck s17 a19 rs1
feature: Y505 Lck s17 a19 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot D4A5Q1 359
type: UnificationXref
id: D4A5Q1
db: uniprot

Proto-oncogene vav
type: ProteinReference
xref: uniprot P27870 31
xref: PTHR45818:SF2
organism: Mus musculus

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: uniprot Q62829 329
xref: PTHR48015:SF30
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SV58 122
xref: PTHR23050:SF383
organism: Monodelphis domestica

B7-1 protein
type: ProteinReference
xref: PTHR25466:SF4
xref: uniprot Q9TQX1 534
organism: Canis lupus familiaris

uniprot P01100 198
type: UnificationXref
id: P01100
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19134:SF284
xref: uniprot A0A1D5PR76 444
organism: Gallus gallus

uniprot H9FVU5 387
type: UnificationXref
id: H9FVU5
db: uniprot

Y CD28 s37 sa38 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y CD28 s37 sa38 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot P48453 290
organism: Mus musculus

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot P48452 289
organism: Bos taurus

jun s303 a501 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 12

uniprot F6SHC1 452
type: UnificationXref
id: F6SHC1
db: uniprot

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR45673:SF2
xref: uniprot P48455 292
organism: Mus musculus

STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r68
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 796
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 797
left: IKK
interaction type: STATE_TRANSITION
right: IKK

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR45673:SF2
xref: uniprot P48454 291
organism: Homo sapiens

PKC-theta
type: Protein
entity reference: PKC-theta
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

T-lymphocyte activation antigen CD86
type: ProteinReference
xref: PTHR25466:SF2
xref: uniprot P42082 532
organism: Mus musculus

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

HETERODIMER_ASSOCIATION_LEFT__PKC_theta-_DAG-RIGHT__Complex__DAG_PKC_theta_-_r45
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 775
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 773
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 774
left: PKC-theta
left: DAG
interaction type: HETERODIMER_ASSOCIATION
right: Complex (DAG/PKC-theta)

T-lymphocyte activation antigen CD86
type: ProteinReference
xref: PTHR25466:SF2
xref: uniprot P42081 531
organism: Homo sapiens

uniprot Q503B6 164
type: UnificationXref
id: Q503B6
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: STATE_TRANSITION_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r106
control type: ACTIVATION
controller: IP3R

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot O14920 456
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6T2E7 314
xref: PTHR48015:SF22
organism: Xenopus tropicalis

y CD3 delta s56 sa57 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 delta s56 sa57 rs1 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8870116001312134
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y

uniprot P42082 532
type: UnificationXref
id: P42082
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7GWI2 320
xref: PTHR48015:SF22
organism: Macaca mulatta

uniprot P08556 161
type: UnificationXref
id: P08556
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__cdc42_GTP_-_WASP-RIGHT__Complex__cdc42_GTP__WASP_-_r39
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 777
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 776
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 778
left: WASP
left: Complex (cdc42/GTP)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (cdc42/GTP/ WASP)

uniprot P0DP23 134
type: UnificationXref
id: P0DP23
db: uniprot

y CD3 delta s56 sa57 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 delta s56 sa57 rs2 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=2.412924694611101

TCR Beta
type: Protein
entity reference: TCR Beta
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa46 735
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 25

uniprot F6Y4G8 512
type: UnificationXref
id: F6Y4G8
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A7RPI8 101
organism: Nematostella vectensis

PARTICIPANT STOICHIOMETRY r53 888
type: Stoichiometry
physical entity: Complex (jun/fos)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 886
type: Stoichiometry
physical entity: fos
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 887
type: Stoichiometry
physical entity: jun
stoichiometric coefficient: 1.0

Ras s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot O88763 395
type: UnificationXref
id: O88763
db: uniprot

uniprot D4A3M8 261
type: UnificationXref
id: D4A3M8
db: uniprot

PTHR48015:SF22
type: RelationshipXref
id: PTHR48015:SF22
db: PANTHER Family
relationship type: By Homology

cdc42
type: ProteinReference
xref: P01333
standard name: Cell division cycle 42
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.cdc42
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cell division control protein 42 homolog
member entity reference: Cell division control protein 42 homolog isoform 2
member entity reference: Uncharacterized protein
member entity reference: Cell division cycle 42

PTHR48015:SF20
type: RelationshipXref
id: PTHR48015:SF20
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 513
xref: PTHR24055:SF222
organism: Macaca mulatta

uniprot A9S9L5 106
type: UnificationXref
id: A9S9L5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7G3I5 380
organism: Monodelphis domestica

uniprot J9P5W6 237
type: UnificationXref
id: J9P5W6
db: uniprot

Predicted protein (Fragment)
type: ProteinReference
xref: uniprot A7RPN8 103
organism: Nematostella vectensis

uniprot A0A0G2K344 348
type: UnificationXref
id: A0A0G2K344
db: uniprot

PARTICIPANT STOICHIOMETRY r36 793
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 794
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 795
type: Stoichiometry
physical entity: Complex (rac/GTP)
stoichiometric coefficient: 1.0

uniprot A0A2I3THL4 210
type: UnificationXref
id: A0A2I3THL4
db: uniprot

eco ECO:0000250 12
type: UnificationXref
id: ECO:0000250
db: eco

TRANSPORT_LEFT__NF_kappa_B-RIGHT__NF_kappa_B-_r92
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 837
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 836
left: NF-kappa B
interaction type: TRANSPORT
right: NF-kappa B

PARTICIPANT STOICHIOMETRY r36 792
type: Stoichiometry
physical entity: Complex (rac/GDP)
stoichiometric coefficient: 1.0

MEKK
type: ProteinReference
xref: P01297
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: MEKK Synonym: MAP kinase kinase kinase,MEK kinase Accession: P01297
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.MEKK
member entity reference: Mitogen-activated protein kinase kinase kinase 1
member entity reference: Uncharacterized protein

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F6WV79 511
organism: Monodelphis domestica

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A3Q1M353 212
xref: PTHR44329:SF47
organism: Bos taurus

HOMODIMER ID 83STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 eta
stoichiometric coefficient: 2.0

MHC -antigen
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa47 737
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q0U9 445
type: UnificationXref
id: H2Q0U9
db: uniprot

CD3 eta s57 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 eta
stoichiometric coefficient: 2.0

uniprot E2RNP2 302
type: UnificationXref
id: E2RNP2
db: uniprot

fos
type: ProteinReference
xref: P01309
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.fos
comment: ENTITY_REFERENCE_NOTES= Long Name: fos Synonym: c-fos Accession: P01309
member entity reference: Proto-oncogene c-Fos
member entity reference: C-fos
member entity reference: Uncharacterized protein
member entity reference: Fos proto-oncogene, AP-1 transcription factor subunit

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

uniprot Q9Z1E3 421
type: UnificationXref
id: Q9Z1E3
db: uniprot

GRAP2 isoform 1
type: ProteinReference
xref: PTHR46037:SF3
xref: uniprot A0A2J8LNE4 441
organism: Pan troglodytes

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Jnk-RIGHT__Jnk-_r54
controller: MEKK

uniprot F7H9J1 49
type: UnificationXref
id: F7H9J1
db: uniprot

uniprot F6QP11 480
type: UnificationXref
id: F6QP11
db: uniprot

uniprot P05625 221
type: UnificationXref
id: P05625
db: uniprot

Y191 LAT s97 sa101 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y191
feature location: Y191 LAT s97 sa101 rs4 Y191
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y191
comment: MODIFICATION_RESIDUE_ANGLE=5.800300360425278

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Lck-RIGHT__ADP-_Lck-_r7
controller: Csk

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q92569 411
organism: Homo sapiens

uniprot J9NXY2 129
type: UnificationXref
id: J9NXY2
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 207
evidence: Evidence 209
evidence: Evidence 206
evidence: Evidence 208
xref: uniprot A0A2I3THL4 210
xref: PTHR44329:SF22
organism: Pan troglodytes

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 138

Grb2 s78 sa76 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

ncbitaxon 7668 152
type: UnificationXref
id: 7668
db: ncbitaxon

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1NH21 472
xref: PTHR24356:SF176
organism: Bos taurus

PLC gamma s411 a305 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7GAP5 381
xref: PTHR10048:SF33
organism: Ornithorhynchus anatinus

uniprot Q04982 228
type: UnificationXref
id: Q04982
db: uniprot

uniprot F6X434 285
type: UnificationXref
id: F6X434
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P21708 69
xref: PTHR24055:SF393
organism: Rattus norvegicus

PKC-theta
type: ProteinReference
xref: P01318
standard name: Protein kinase C, theta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: PKC theta Synonym: Protein Kinase C theta Accession: P01318
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.PKC-theta
member entity reference: Protein kinase C theta type
member entity reference: Protein kinase C

PLC gamma s90 sa91 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

uniprot F7D094 265
type: UnificationXref
id: F7D094
db: uniprot

MHC antigen s53 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MHC -antigen
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot A0A1D5NVQ5 6
organism: Gallus gallus

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot Q13233 53
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P29994 469
xref: PTHR13715:SF52
organism: Rattus norvegicus

uniprot Q95KV0 460
type: UnificationXref
id: Q95KV0
db: uniprot

Complex (Ras/GTP/ Raf/MEK)
type: Complex
component stoichiometry: Ras s82 sa80 STOICHIOMETRY ID COMPLEX
component stoichiometry: Raf s84 sa82 STOICHIOMETRY ID COMPLEX
component stoichiometry: MEK s85 sa83 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s83 sa81 STOICHIOMETRY ID COMPLEX
component: Raf
component: Ras
component: GTP
component: MEK
feature: COMPLEX BINDING FEATURE s449 a691 690
feature: COMPLEX BINDING FEATURE s449 a691 688
feature: COMPLEX BINDING FEATURE s449 a691 686
feature: COMPLEX BINDING FEATURE s449 a691 684
cellular location: cytosol

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot F6SHC1 452
organism: Macaca mulatta

cdc42
type: Protein
entity reference: cdc42
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa14 749
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot G3V671 527
type: UnificationXref
id: G3V671
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O00329 388
xref: PTHR10048:SF35
organism: Homo sapiens

Grb2 s28 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

uniprot Q6P023 75
type: UnificationXref
id: Q6P023
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 76

PARTICIPANT STOICHIOMETRY r96 828
type: Stoichiometry
physical entity: Complex (TCR Beta/MHC-antigen/ TCR alpha/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r91 838
type: Stoichiometry
physical entity: Jnk
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r96 827
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r91 839
type: Stoichiometry
physical entity: Jnk
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r96 826
type: Stoichiometry
physical entity: Complex (TCR Beta/MHC-antigen/ CD3 gamma/TCR alpha/ CD3 eta/CD3 delta/ TCR zeta)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r96 825
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

jun
type: Protein
entity reference: jun
feature: jun s302 a500 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2J8QY32 355
type: UnificationXref
id: A0A2J8QY32
db: uniprot

T-cell surface glycoprotein CD3 zeta chain
type: ProteinReference
xref: uniprot P24161 41
xref: PTHR10035:SF2
organism: Mus musculus

y CD3 eta s62 sa63 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 eta s62 sa63 rs1 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=3.91785828020355

TRANSCRIPTION_LEFT__TCR_responsive_genes-RIGHT__TCR_responsive_genes-_re62
type: TemplateReaction
product: TCR-responsive genes
xref: TRANSCRIPTION
participant: TCR-responsive genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Wiskott-Aldrich syndrome protein
type: ProteinReference
xref: uniprot P42768 503
xref: PTHR23202:SF3
organism: Homo sapiens

ncbitaxon 6669 121
type: UnificationXref
id: 6669
db: ncbitaxon

y CD3 eta s43 sa44 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 eta s43 sa44 rs1 y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=3.91785828020355

uniprot Q9TQX1 534
type: UnificationXref
id: Q9TQX1
db: uniprot

uniprot Q0JNS6 143
type: UnificationXref
id: Q0JNS6
db: uniprot

Y TCR zeta s58 sa59 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s58 sa59 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7443253848069942
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 100

MEKK
type: Protein
entity reference: MEKK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot D4A5Q1 359
organism: Rattus norvegicus

PTHR46680:SF1
type: RelationshipXref
id: PTHR46680:SF1
db: PANTHER Family
relationship type: By Homology

Y TCR zeta s73 sa71 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s73 sa71 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=6.2116579744416045
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot F1P4Q4 263
organism: Gallus gallus

y CD3 eta s62 sa63 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 eta s62 sa63 rs2 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=2.412924694611101

PKC theta s24 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKC-theta
stoichiometric coefficient: 1.0

ncbitaxon 237631 100
type: UnificationXref
id: 237631
db: ncbitaxon

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A2I3TRY9 354
xref: PTHR10048:SF7
organism: Pan troglodytes

Y TCR zeta s58 sa59 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s58 sa59 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.3576366636899095
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot P27361 70
type: UnificationXref
id: P27361
db: uniprot

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot P15056 226
xref: PTHR44329:SF47
organism: Homo sapiens

ZAP-70
type: Protein
entity reference: ZAP-70
feature: Y ZAP 70 s64 sa65 rs2
feature: Y ZAP 70 s64 sa65 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa65 731
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r106 845
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r106 844
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 1.0

Raf s84 sa82 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

CD3 delta s42 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 delta
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XP81 483
xref: PTHR24356:SF171
organism: Xenopus tropicalis

uniprot Q63844 74
type: UnificationXref
id: Q63844
db: uniprot

NF AT s293 a486 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=-0.0

Y TCR zeta s73 sa71 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s73 sa71 rs4 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=5.77761058581875

I kappa B s318 a526 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Y TCR zeta s58 sa59 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s58 sa59 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=6.2116579744416045
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Putative calmodulin
type: ProteinReference
xref: uniprot A0A0D1DU81 99
organism: Ustilago maydis

uniprot P63000 423
type: UnificationXref
id: P63000
db: uniprot

Y TCR zeta s73 sa71 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s73 sa71 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7443253848069942
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

PARTICIPANT STOICHIOMETRY r87 874
type: Stoichiometry
physical entity: Complex (CD28/B7)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r87 873
type: Stoichiometry
physical entity: B7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r87 872
type: Stoichiometry
physical entity: CD28
stoichiometric coefficient: 2.0

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 15

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__rac_GDP_-_GTP-RIGHT__GDP-_Complex__rac_GTP_-_r36
controller: Complex (LAT/Gads/ SLP-76/vav/ nck)

SLP 76 s106 sa110 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SLP-76
stoichiometric coefficient: 1.0

Y TCR zeta s58 sa59 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s58 sa59 rs4 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=5.77761058581875

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Gads s105 sa109 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gads
stoichiometric coefficient: 1.0

Y TCR zeta s73 sa71 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s73 sa71 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.3576366636899095
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Y191 LAT s66 sa98 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y191
feature location: Y191 LAT s66 sa98 rs4 Y191
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y191
comment: MODIFICATION_RESIDUE_ANGLE=5.800300360425278

TCR zeta s58 sa59 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR zeta
stoichiometric coefficient: 2.0

uniprot O14920 456
type: UnificationXref
id: O14920
db: uniprot

uniprot A0A2I3T4A4 10
type: UnificationXref
id: A0A2I3T4A4
db: uniprot

HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR zeta
stoichiometric coefficient: 2.0

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: PTHR45818:SF1
xref: uniprot E1BBD2 16
organism: Bos taurus

rac
type: ProteinReference
xref: P01324
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.rac
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: GTPase cRac1A
member entity reference: Rac family small GTPase 1
member entity reference: Rac family small GTPase 1b
member entity reference: Uncharacterized protein
member entity reference: Rac family small GTPase 3a
member entity reference: Rac family small GTPase 2
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Rac family small GTPase 1a

CD80 isoform 1
type: ProteinReference
xref: uniprot A0A2J8M3E9 522
xref: PTHR25466:SF4
organism: Pan troglodytes

uniprot P10686 338
type: UnificationXref
id: P10686
db: uniprot

Gads
type: ProteinReference
xref: P01327
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Gads
comment: ENTITY_REFERENCE_NOTES=
member entity reference: GRAP2 isoform 1
member entity reference: GRB2-related adapter protein 2

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7HLC7 382
xref: PTHR10048:SF35
organism: Macaca mulatta

Y191 LAT s89 sa90 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y191
feature location: Y191 LAT s89 sa90 rs4 Y191
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y191
comment: MODIFICATION_RESIDUE_ANGLE=5.800300360425278

DISSOCIATION_LEFT__Complex__NF_kappa_B_I_kappa_B_-RIGHT__NF_kappa_B-_I_kappa_B-_r67
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 808
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 809
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 810
left: Complex (NF-kappa B/I kappa B)
interaction type: DISSOCIATION
right: I kappa B
right: NF-kappa B

STATE TRANSITION LEFT ATP- Complex TCR Beta MHC antigen CD3 gamma TCR alpha CD3 eta CD3 delta TCR zeta -RIGHT ADP- Complex TCR Beta MHC antigen TCR alpha CD3 gamma CD3 delta CD3 eta TCR zeta - r96
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 826
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 828
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 827
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 825
left: Complex (TCR Beta/MHC-antigen/ CD3 gamma/TCR alpha/ CD3 eta/CD3 delta/ TCR zeta)
left: ATP
display name: STATE_TRANSITION_LEFT__ATP-_Complex__TCR_Beta_MHC_antigen__CD3_gamma_TCR_alpha__CD3_eta_CD3_delta__TCR_zeta_-RIGHT__ADP-_Complex__TCR_Beta_MHC_antigen__TCR_alpha_CD3_gamma__CD3_delta_CD3_eta__TCR_zeta_-_r96
interaction type: STATE_TRANSITION
right: Complex (TCR Beta/MHC-antigen/ TCR alpha/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta)
right: ADP

y CD3 delta s61 sa62 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 delta s61 sa62 rs1 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8870116001312134
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y

CD3 eta
type: Protein
entity reference: CD3 eta
feature: y CD3 eta s62 sa63 rs2
feature: y CD3 eta s62 sa63 rs1

DISSOCIATION_LEFT__Complex__LAT_Pak__Gads_SLP_76__WASP_vav__nck_-RIGHT__Pak-_Complex__LAT_Gads__SLP_76_vav__nck_-_WASP-_r114
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r114 789
participant stoichiometry: PARTICIPANT STOICHIOMETRY r114 788
participant stoichiometry: PARTICIPANT STOICHIOMETRY r114 791
participant stoichiometry: PARTICIPANT STOICHIOMETRY r114 790
left: Complex (LAT/Pak/ Gads/SLP-76/ WASP/vav/ nck)
interaction type: DISSOCIATION
right: WASP
right: Complex (LAT/Gads/ SLP-76/vav/ nck)
right: Pak

STATE_TRANSITION_LEFT__Calcineurin-RIGHT__Calcineurin-_r48
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 767
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 766
left: Calcineurin
interaction type: STATE_TRANSITION
right: Calcineurin

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot O15111 457
xref: PTHR22969:SF13
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RH85 362
xref: PTHR10155:SF1
organism: Canis lupus familiaris

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A3Q1LQK4 356
xref: PTHR10048:SF7
organism: Bos taurus

y CD3 delta s61 sa62 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 delta s61 sa62 rs2 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=2.412924694611101

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF200
xref: uniprot G3X7B5 485
organism: Bos taurus

uniprot P47196 490
type: UnificationXref
id: P47196
db: uniprot

uniprot F6RCU6 482
type: UnificationXref
id: F6RCU6
db: uniprot

MEK
type: ProteinReference
xref: P01312
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: MEK Synonym: MAPK/ERK kinase Accession: P01312
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.MEK
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Mitogen-activated protein kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: MAP2K2 isoform 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Uncharacterized protein
member entity reference: MAP2K1 protein

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot H2QIE3 189
xref: PTHR24418:SF369
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Complex__TCR_Beta_CD3_gamma__CD3_delta_CD3_eta__TCR_zeta_ZAP_70__TCR_alpha_-RIGHT__ADP-_Complex__CD3_gamma_TCR_Beta__CD3_delta_CD3_eta__TCR_zeta_ZAP_70__TCR_alpha_-_r99
controller: ZAP-70

Lck
type: Protein
entity reference: Lck
feature: Y394 Lck s499 a653 rs1
feature: Y505 Lck s499 a653 rs2
feature: ACTIVE 5
comment: SPECIES_TYPE=PROTEIN

uniprot P42338 403
type: UnificationXref
id: P42338
db: uniprot

Pak
type: Protein
entity reference: Pak
feature: COMPLEX PARTICIPANT BINDING FEATURE s98 sa102 577
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y191 LAT s4 a4 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y191
feature location: Y191 LAT s4 a4 rs4 Y191
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y191
comment: MODIFICATION_RESIDUE_ANGLE=5.800300360425278

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Complex__TCR_Beta_CD3_gamma__CD3_delta_CD3_eta__TCR_zeta_ZAP_70__TCR_alpha_-RIGHT__ADP-_Complex__CD3_gamma_TCR_Beta__CD3_delta_CD3_eta__TCR_zeta_ZAP_70__TCR_alpha_-_r99
controller: Lck

uniprot A0A2I3TK00 211
type: UnificationXref
id: A0A2I3TK00
db: uniprot

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: uniprot Q503B6 164
xref: PTHR24070:SF423
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F6T2A6 123
organism: Ciona intestinalis

uniprot F2Z4P5 282
type: UnificationXref
id: F2Z4P5
db: uniprot

uniprot K7BYT0 238
type: UnificationXref
id: K7BYT0
db: uniprot

PARTICIPANT STOICHIOMETRY r4 769
type: Stoichiometry
physical entity: Lck
stoichiometric coefficient: 1.0

Transcription factor AP-1
type: ProteinReference
xref: uniprot P17325 507
xref: PTHR11462:SF8
organism: Rattus norvegicus

HETERODIMER ASSOCIATION LEFT ZAP 70- Complex TCR Beta MHC antigen TCR alpha CD3 gamma CD3 delta CD3 eta TCR zeta -RIGHT Complex TCR Beta CD3 gamma CD3 delta CD3 eta TCR zeta ZAP 70 TCR alpha - r98
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 815
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 816
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 814
left: Complex (TCR Beta/MHC-antigen/ TCR alpha/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta)
left: ZAP-70
display name: HETERODIMER_ASSOCIATION_LEFT__ZAP_70-_Complex__TCR_Beta_MHC_antigen__TCR_alpha_CD3_gamma__CD3_delta_CD3_eta__TCR_zeta_-RIGHT__Complex__TCR_Beta_CD3_gamma__CD3_delta_CD3_eta__TCR_zeta_ZAP_70__TCR_alpha_-_r98
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TCR Beta/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)

uniprot Q04970 162
type: UnificationXref
id: Q04970
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR14098:SF1
xref: uniprot F7C1G6 344
organism: Macaca mulatta

Y TCR zeta s73 sa71 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s73 sa71 rs5 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.278337656950498
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot F1P630 510
type: UnificationXref
id: F1P630
db: uniprot

PARTICIPANT STOICHIOMETRY r4 770
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

ncbitaxon 7739 114
type: UnificationXref
id: 7739
db: ncbitaxon

y CD3 eta s43 sa44 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 eta s43 sa44 rs2 y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=2.412924694611101

Y CD28 s320 a566 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y CD28 s320 a566 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q9Z1E3 421
organism: Mus musculus

uniprot F1Q3M8 367
type: UnificationXref
id: F1Q3M8
db: uniprot

STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 846
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 847
left: ERK
interaction type: STATE_TRANSITION
right: ERK

PTHR10048:SF29
type: RelationshipXref
id: PTHR10048:SF29
db: PANTHER Family
relationship type: By Homology

TCR zeta s73 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR zeta
stoichiometric coefficient: 2.0

uniprot P15056 226
type: UnificationXref
id: P15056
db: uniprot

Y TCR zeta s73 sa71 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s73 sa71 rs6 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=4.644304929068502

PARTICIPANT STOICHIOMETRY r4 768
type: Stoichiometry
physical entity: Lck
stoichiometric coefficient: 1.0

uniprot Q01621 203
type: UnificationXref
id: Q01621
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot A0A1D5R8E9 333
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r112 813
type: Stoichiometry
physical entity: Complex (PIP3/Akt)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r112 812
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

uniprot Q95ME4 167
type: UnificationXref
id: Q95ME4
db: uniprot

PARTICIPANT STOICHIOMETRY r112 811
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: uniprot O70167 393
xref: PTHR10048:SF29
organism: Mus musculus

Ras
type: Protein
entity reference: Ras
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa80 685
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Calcineurin
type: Protein
entity reference: Calcineurin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: uniprot P23726 396
xref: PTHR10155:SF1
organism: Bos taurus

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P23727 397
organism: Bos taurus

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q63932 247
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F6TAH0 335
xref: PTHR10336:SF173
organism: Monodelphis domestica

uniprot E9H5Z2 120
type: UnificationXref
id: E9H5Z2
db: uniprot

Ras s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot K7CZM1 180
type: UnificationXref
id: K7CZM1
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: uniprot O70173 394
xref: PTHR10048:SF29
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6RCU6 482
organism: Macaca mulatta

uniprot A0A3S5ZPP7 342
type: UnificationXref
id: A0A3S5ZPP7
db: uniprot

PLC-gamma
type: Protein
entity reference: PLC-gamma
feature: ACTIVE 5
feature: PLC gamma s455 a725 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6X927 453
xref: PTHR22969:SF13
organism: Macaca mulatta

uniprot E1BMG4 301
type: UnificationXref
id: E1BMG4
db: uniprot

uniprot Q1LZB2 272
type: UnificationXref
id: Q1LZB2
db: uniprot

Tyrosine-protein kinase ZAP-70
type: ProteinReference
xref: PTHR24418:SF369
xref: uniprot P43403 190
organism: Homo sapiens

Pi
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Tyrosine-protein kinase ZAP-70
type: ProteinReference
xref: uniprot P43404 191
xref: PTHR24418:SF369
organism: Mus musculus

uniprot Q7YQL4 331
type: UnificationXref
id: Q7YQL4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6WX28 195
xref: PTHR23351:SF4
organism: Monodelphis domestica

uniprot O16305 130
type: UnificationXref
id: O16305
db: uniprot

CD247 molecule
type: ProteinReference
xref: uniprot Q0VCU4 42
xref: PTHR10035:SF2
organism: Bos taurus

Calcineurin
type: Protein
entity reference: Calcineurin
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42336 401
xref: PTHR10048:SF107
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot P42338 403
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 402
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot W4YPT6 153
organism: Strongylocentrotus purpuratus

STATE_TRANSITION_LEFT__LAT-RIGHT__LAT-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 765
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 764
left: LAT
interaction type: STATE_TRANSITION
right: LAT

CD3 delta
type: Protein
entity reference: CD3 delta
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa62 725
feature: y CD3 delta s61 sa62 rs2
feature: y CD3 delta s61 sa62 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A452DI16 213
type: UnificationXref
id: A0A452DI16
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F1P859 171
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__Complex__rac_GDP_-_GTP-RIGHT__GDP-_Complex__rac_GTP_-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 794
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 793
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 792
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 795
left: GTP
left: Complex (rac/GDP)
interaction type: STATE_TRANSITION
right: GDP
right: Complex (rac/GTP)

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r115
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r115 782
participant stoichiometry: PARTICIPANT STOICHIOMETRY r115 783
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

TCR zeta s63 sa64 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR zeta
stoichiometric coefficient: 2.0

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q6PF93 408
xref: PTHR10048:SF7
organism: Mus musculus

ERK
type: Protein
entity reference: ERK
feature: T ERK s236 a379 rs1
feature: Y ERK s236 a379 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q52WY2 500
type: UnificationXref
id: Q52WY2
db: uniprot

CD247 isoform 2
type: ProteinReference
xref: uniprot H2R2L9 39
xref: PTHR10035:SF2
organism: Pan troglodytes

Y TCR zeta s51 sa52 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s51 sa52 rs6 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=4.644304929068502

PTHR14098:SF1
type: RelationshipXref
id: PTHR14098:SF1
db: PANTHER Family
relationship type: By Homology

GTPase NRas
type: ProteinReference
xref: uniprot Q95ME4 167
xref: PTHR24070:SF189
organism: Monodelphis domestica

CD80 antigen, isoform CRA_a
type: ProteinReference
xref: PTHR25466:SF4
xref: uniprot G3V671 527
organism: Rattus norvegicus

uniprot H2Q867 416
type: UnificationXref
id: H2Q867
db: uniprot

Lymphocyte cytosolic protein 2
type: ProteinReference
xref: PTHR14098:SF1
xref: uniprot A0A3S5ZPP7 342
organism: Gallus gallus

uniprot H9FU38 467
type: UnificationXref
id: H9FU38
db: uniprot

DAG
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa24 697
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Calmodulin
type: ProteinReference
xref: uniprot B3RJX8 111
organism: Trichoplax adhaerens

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot F6W7C8 373
xref: PTHR10048:SF34
organism: Macaca mulatta

uniprot P0DP28 135
type: UnificationXref
id: P0DP28
db: uniprot

PLC-gamma
type: Protein
entity reference: PLC-gamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 sa91 609
feature: PLC gamma s90 sa91 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2J8LNE4 441
type: UnificationXref
id: A0A2J8LNE4
db: uniprot

uniprot H2PXY8 384
type: UnificationXref
id: H2PXY8
db: uniprot

PTHR24361:SF414
type: RelationshipXref
id: PTHR24361:SF414
db: PANTHER Family
relationship type: By Homology

Raf
type: ProteinReference
xref: P01311
standard name: Raf Oncogene
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Raf Synonym: Synonym not specified Accession: P01311
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Raf
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase B-raf
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: B-Raf proto-oncogene, serine/threonine kinase
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: A-Raf proto-oncogene, serine/threonine kinase

PTHR11494:SF7
type: RelationshipXref
id: PTHR11494:SF7
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot P63329 294
organism: Rattus norvegicus

GTP s110 sa85 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot P63328 293
organism: Mus musculus

uniprot P19174 339
type: UnificationXref
id: P19174
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Complex__CD28_B7_-RIGHT__ADP-_Complex__CD28_B7_-_r88
controller: Lck

uniprot Q0VCU4 42
type: UnificationXref
id: Q0VCU4
db: uniprot

uniprot E3KLJ3 118
type: UnificationXref
id: E3KLJ3
db: uniprot

STATE_TRANSITION_LEFT__Jnk-RIGHT__Jnk-_r54
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 881
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 880
left: Jnk
interaction type: STATE_TRANSITION
right: Jnk

uniprot F7DUD6 376
type: UnificationXref
id: F7DUD6
db: uniprot

Y TCR zeta s51 sa52 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s51 sa52 rs4 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=5.77761058581875

uniprot P06240 202
type: UnificationXref
id: P06240
db: uniprot

uniprot E2RL20 215
type: UnificationXref
id: E2RL20
db: uniprot

uniprot Q62829 329
type: UnificationXref
id: Q62829
db: uniprot

TCR alpha s65 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR alpha
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q9XT09 249
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF427
xref: uniprot J9NWQ5 128
organism: Canis lupus familiaris

uniprot A0A2J8M3E9 522
type: UnificationXref
id: A0A2J8M3E9
db: uniprot

Y132 LAT s104 sa108 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y132
feature location: Y132 LAT s104 sa108 rs2 Y132
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3298847729394225
comment: MODIFICATION_RESIDUE_NAME=Y132

Calmodulin
type: Protein
entity reference: Calmodulin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P28028 227
type: UnificationXref
id: P28028
db: uniprot

Raf
type: Protein
entity reference: Raf
feature: COMPLEX PARTICIPANT BINDING FEATURE s111 sa86 639
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H9FYU7 179
type: UnificationXref
id: H9FYU7
db: uniprot

Y TCR zeta s51 sa52 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s51 sa52 rs5 Y
comment: MODIFICATION_RESIDUE_ANGLE=5.278337656950498
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

TCR-responsive genes
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

uniprot P31750 488
type: UnificationXref
id: P31750
db: uniprot

uniprot E2RJX4 474
type: UnificationXref
id: E2RJX4
db: uniprot

uniprot P19377 440
type: UnificationXref
id: P19377
db: uniprot

uniprot A0A2I3T4Q0 449
type: UnificationXref
id: A0A2I3T4Q0
db: uniprot

Complex (rac/GTP/ Pak)
type: Complex
component stoichiometry: rac s18 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pak s21 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s20 sa22 STOICHIOMETRY ID COMPLEX
component: GTP
component: rac
component: Pak
feature: COMPLEX BINDING FEATURE s270 a454 680
feature: COMPLEX BINDING FEATURE s270 a454 682
feature: COMPLEX BINDING FEATURE s270 a454 678
cellular location: cytosol

uniprot E1BBD2 16
type: UnificationXref
id: E1BBD2
db: uniprot

TCR alpha
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa55 649
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y TCR zeta s51 sa52 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s51 sa52 rs2 Y
comment: MODIFICATION_RESIDUE_ANGLE=0.3576366636899095
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

ERK
type: Protein
entity reference: ERK
feature: Y ERK s249 a404 rs2
feature: ACTIVE 5
feature: T ERK s249 a404 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAP2K1 protein
type: ProteinReference
xref: uniprot Q0VD16 244
xref: PTHR48013:SF5
organism: Bos taurus

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot J9P5W6 237
organism: Canis lupus familiaris

MHC -antigen
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s53 sa54 647
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F6QUW1 173
organism: Monodelphis domestica

TCR Beta
type: Protein
entity reference: TCR Beta
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa60 721
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot J9NWQ5 128
type: UnificationXref
id: J9NWQ5
db: uniprot

uniprot F1PRG4 477
type: UnificationXref
id: F1PRG4
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 3

uniprot H2Q4W0 437
type: UnificationXref
id: H2Q4W0
db: uniprot

uniprot A0A1D5PXC6 508
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9Y243 494
organism: Homo sapiens

Y TCR zeta s51 sa52 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s51 sa52 rs3 Y
comment: MODIFICATION_RESIDUE_ANGLE=6.2116579744416045
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Uncharacterized protein
type: ProteinReference
xref: uniprot D3ZVW0 55
organism: Rattus norvegicus

uniprot F1LWB1 20
type: UnificationXref
id: F1LWB1
db: uniprot

MAP2K2 isoform 1
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot K7BYT0 238
organism: Pan troglodytes

uniprot H2PZQ7 158
type: UnificationXref
id: H2PZQ7
db: uniprot

PIK3R1 isoform 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot A0A2I3SIY1 352
organism: Pan troglodytes

…
type: Stoichiometry
physical entity: CD28
stoichiometric coefficient: 2.0

ncbitaxon 9913 17
type: UnificationXref
id: 9913
db: ncbitaxon

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 719
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7FDA0 379
xref: PTHR10048:SF33
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot P31938 239
xref: PTHR48013:SF5
organism: Mus musculus

ZAP-70
type: Protein
entity reference: ZAP-70
feature: Y ZAP 70 s507 sa72 rs2
feature: Y ZAP 70 s507 sa72 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s507 sa72 557
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y132 LAT s97 sa101 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y132
feature location: Y132 LAT s97 sa101 rs2 Y132
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3298847729394225
comment: MODIFICATION_RESIDUE_NAME=Y132

uniprot P22646 80
type: UnificationXref
id: P22646
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F6VQP7 466
organism: Monodelphis domestica

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa76 593
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Linker for activation of T-cells family member 1
type: ProteinReference
xref: uniprot O43561 433
xref: PTHR15586:SF0
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E1B8P9 59
xref: PTHR24055:SF393
organism: Bos taurus

IP3
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF427
xref: uniprot F7CLC0 125
organism: Monodelphis domestica

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot K7CZM1 180
xref: PTHR23113:SF150
organism: Pan troglodytes

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 175

uniprot Q64303 330
type: UnificationXref
id: Q64303
db: uniprot

uniprot Q6RUV5 431
type: UnificationXref
id: Q6RUV5
db: uniprot

Ras
type: Protein
entity reference: Ras
feature: COMPLEX PARTICIPANT BINDING FEATURE s109 sa84 635
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TCR alpha s75 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR alpha
stoichiometric coefficient: 1.0

PLC gamma s94 sa95 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

uniprot F7CLC0 125
type: UnificationXref
id: F7CLC0
db: uniprot

Evidence 219
type: Evidence
evidence code: IDA
comment: SPACC P04049

uniprot C3ZEW0 115
type: UnificationXref
id: C3ZEW0
db: uniprot

Cytoplasmic protein NCK1
type: ProteinReference
xref: uniprot Q99M51 273
xref: PTHR19969:SF16
organism: Mus musculus

uniprot Q13177 327
type: UnificationXref
id: Q13177
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E823 62
xref: PTHR24055:SF203
organism: Monodelphis domestica

Y171 LAT s4 a4 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y171
feature location: Y171 LAT s4 a4 rs3 Y171
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7720410517750427
comment: MODIFICATION_RESIDUE_NAME=Y171

Grb2
type: ProteinReference
xref: P01303
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Grb2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Growth factor receptor-bound protein 2
member entity reference: Growth factor receptor-bound protein 2a

Complex (DAG/PKC-theta)
type: Complex
component stoichiometry: DAG s22 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: PKC theta s24 sa25 STOICHIOMETRY ID COMPLEX
component: PKC-theta
component: DAG
feature: COMPLEX BINDING FEATURE s285 a476 698
feature: COMPLEX BINDING FEATURE s285 a476 696
cellular location: cytosol

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60952 498
xref: PTHR24072:SF136
organism: Canis lupus familiaris

Proto-oncogene vav
type: ProteinReference
xref: uniprot P15498 28
xref: PTHR45818:SF2
organism: Homo sapiens

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60953 499
xref: PTHR24072:SF136
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r28
controller: MEK

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A2I3TK00 211
xref: PTHR44329:SF47
organism: Pan troglodytes

Evidence 224
type: Evidence
evidence code: IDA
comment: SPACC P11345

CD28
type: Protein
entity reference: CD28
feature: Y CD28 s320 a566 rs1

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 19

uniprot F7EP57 377
type: UnificationXref
id: F7EP57
db: uniprot

Pak
type: Protein
entity reference: Pak
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa23 683
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GTPase cRac1A
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6LC82 430
organism: Gallus gallus

uniprot P04049 218
type: UnificationXref
id: P04049
db: uniprot

T-cell surface glycoprotein CD3 zeta chain
type: ProteinReference
xref: uniprot P20963 40
xref: PTHR10035:SF2
organism: Homo sapiens

uniprot A0A3Q1LSY0 307
type: UnificationXref
id: A0A3Q1LSY0
db: uniprot

uniprot F1MX21 465
type: UnificationXref
id: F1MX21
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F1MAI3 169
organism: Rattus norvegicus

uniprot A0A3Q2TY19 509
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

Evidence 231
type: Evidence
evidence code: IDA
comment: SPACC Q99N57

uniprot E1B8P9 59
type: UnificationXref
id: E1B8P9
db: uniprot

jun
type: Protein
entity reference: jun
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa26 641
feature: jun s25 sa26 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q02111 304
organism: Mus musculus

uniprot A0A2I3RH39 351
type: UnificationXref
id: A0A2I3RH39
db: uniprot

uniprot Q5F352 165
type: UnificationXref
id: Q5F352
db: uniprot

ZAP-70
type: Protein
entity reference: ZAP-70
feature: Y ZAP 70 s404 a633 rs1
feature: Y ZAP 70 s404 a633 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Complex (PIP3/Akt)
type: Complex
component stoichiometry: Akt s34 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: PIP3 s33 sa34 STOICHIOMETRY ID COMPLEX
component: PIP3
component: Akt
feature: COMPLEX BINDING FEATURE s335 a561 708
feature: COMPLEX BINDING FEATURE s335 a561 710
cellular location: cytosol

uniprot F6Y841 374
type: UnificationXref
id: F6Y841
db: uniprot

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa22 681
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CD3 eta s49 sa50 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 eta
stoichiometric coefficient: 2.0

Y226 LAT s76 sa74 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y226
feature location: Y226 LAT s76 sa74 rs5 Y226
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.5851730116547973
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y226

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EH19 63
xref: PTHR24055:SF203
organism: Xenopus tropicalis

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E2RFF7 91
xref: PTHR24418:SF407
organism: Canis lupus familiaris

CD45
type: Complex
component stoichiometry: CD45 s386 a632 STOICHIOMETRY ID COMPLEX
component: CD45
cellular location: cytosol

PARTICIPANT STOICHIOMETRY r101 870
type: Stoichiometry
physical entity: Complex (Ras/GTP/ Raf)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r101 871
type: Stoichiometry
physical entity: Complex (Ras/GTP/ Raf/MEK)
stoichiometric coefficient: 1.0

PLC-gamma
type: Protein
entity reference: PLC-gamma
feature: PLC gamma s81 sa79 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa79 599
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MEKK-RIGHT__MEKK-_r85
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 885
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 884
left: MEKK
interaction type: STATE_TRANSITION
right: MEKK

Y ZAP 70 s507 sa72 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ZAP 70 s507 sa72 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.496387147055939
comment: MODIFICATION_RESIDUE_NAME=Y

Evidence 209
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

CATALYSIS
type: Catalysis
controlled: STATE TRANSITION LEFT ATP- Complex TCR Beta MHC antigen CD3 gamma TCR alpha CD3 eta CD3 delta TCR zeta -RIGHT ADP- Complex TCR Beta MHC antigen TCR alpha CD3 gamma CD3 delta CD3 eta TCR zeta - r96
controller: Lck

ncbitaxon 45351 102
type: UnificationXref
id: 45351
db: ncbitaxon

Evidence 206
type: Evidence
evidence code: ISS
comment: SPACC P04049

Evidence 207
type: Evidence
evidence code: ISS
comment: SPACC P05625

Evidence 208
type: Evidence
evidence code: ISS
comment: SPACC P11345

uniprot P63001 424
type: UnificationXref
id: P63001
db: uniprot

uniprot P32577 95
type: UnificationXref
id: P32577
db: uniprot

PARTICIPANT STOICHIOMETRY r101 869
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot P32577 95
xref: PTHR24418:SF407
organism: Rattus norvegicus

uniprot O54957 434
type: UnificationXref
id: O54957
db: uniprot

T-cell-specific surface glycoprotein CD28
type: ProteinReference
xref: uniprot Q28071 256
xref: PTHR11494:SF7
organism: Bos taurus

I kappa B
type: Protein
entity reference: I kappa B
feature: I kappa B s318 a526 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

T-cell surface glycoprotein CD3 epsilon chain
type: ProteinReference
xref: uniprot Q28073 82
xref: PTHR10570:SF9
organism: Bos taurus

uniprot P32871 400
type: UnificationXref
id: P32871
db: uniprot

uniprot F1P859 171
type: UnificationXref
id: F1P859
db: uniprot

uniprot A0A1D5PXS9 90
type: UnificationXref
id: A0A1D5PXS9
db: uniprot

uniprot A0A1D5Q8S7 274
type: UnificationXref
id: A0A1D5Q8S7
db: uniprot

MEK s85 sa83 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

GRB2-related adapter protein 2
type: ProteinReference
xref: PTHR46037:SF3
xref: uniprot F7AN37 442
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot Q9JHG7 412
organism: Mus musculus

ADP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot G7NCB9 77
type: UnificationXref
id: G7NCB9
db: uniprot

Y505 Lck s480 a18 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y505
feature location: Y505 Lck s480 a18 rs2 Y505
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y505
comment: MODIFICATION_RESIDUE_ANGLE=3.15

PTHR22969:SF13
type: RelationshipXref
id: PTHR22969:SF13
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9606 29
type: UnificationXref
id: 9606
db: ncbitaxon

Gads
type: Protein
entity reference: Gads
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa99 603
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r45 775
type: Stoichiometry
physical entity: Complex (DAG/PKC-theta)
stoichiometric coefficient: 1.0

uniprot Q9WTU6 521
type: UnificationXref
id: Q9WTU6
db: uniprot

PARTICIPANT STOICHIOMETRY r45 773
type: Stoichiometry
physical entity: PKC-theta
stoichiometric coefficient: 1.0

VAV1 isoform 2
type: ProteinReference
xref: uniprot H2QF58 26
xref: PTHR45818:SF2
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r45 774
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

Y ZAP 70 s507 sa72 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ZAP 70 s507 sa72 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.6894200745829581

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: uniprot O75914 322
xref: PTHR48015:SF30
organism: Homo sapiens

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot O88351 458
organism: Mus musculus

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P47196 490
organism: Rattus norvegicus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P47197 491
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HE20 38
xref: PTHR10035:SF2
organism: Macaca mulatta

eco ECO:0000501 229
type: UnificationXref
id: ECO:0000501
db: eco

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__TCR_responsive_genes-RIGHT__TCR_responsive_genes-_re62
control type: ACTIVATION
controller: Complex (jun/fos)

uniprot Q28EW2 163
type: UnificationXref
id: Q28EW2
db: uniprot

uniprot E2RJA0 312
type: UnificationXref
id: E2RJA0
db: uniprot

uniprot Q6LC82 430
type: UnificationXref
id: Q6LC82
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: MEK s247 a692 rs1
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PIP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Y226 LAT s104 sa108 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y226
feature location: Y226 LAT s104 sa108 rs5 Y226
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.5851730116547973
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y226

CD3 gamma
type: ProteinReference
xref: P01317
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.CD3_br_gamma
comment: ENTITY_REFERENCE_NOTES=
member entity reference: T-cell surface glycoprotein CD3 gamma chain
member entity reference: Uncharacterized protein

DAG
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

WASP s16 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WASP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot G7NCB9 77
xref: PTHR10570:SF9
organism: Macaca mulatta

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot Q1LZB2 272
organism: Bos taurus

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: uniprot Q7YQL4 331
xref: PTHR48015:SF30
organism: Pan troglodytes

Y ZAP 70 s404 a633 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ZAP 70 s404 a633 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.6894200745829581

uniprot O43561 433
type: UnificationXref
id: O43561
db: uniprot

ERK
type: Protein
entity reference: ERK
feature: Y ERK s248 a403 rs2
feature: ACTIVE 5
feature: T ERK s248 a403 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E2RNP2 302
organism: Canis lupus familiaris

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

uniprot Q04759 305
type: UnificationXref
id: Q04759
db: uniprot

CD28 s320 a566 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD28
stoichiometric coefficient: 2.0

uniprot E7EXT6 475
type: UnificationXref
id: E7EXT6
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 150

PARTICIPANT STOICHIOMETRY r94 832
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r94 833
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

Y ZAP 70 s404 a633 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ZAP 70 s404 a633 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.496387147055939
comment: MODIFICATION_RESIDUE_NAME=Y

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot A0A2I3RJ26 275
organism: Pan troglodytes

uniprot E1BS97 309
type: UnificationXref
id: E1BS97
db: uniprot

uniprot O55033 270
type: UnificationXref
id: O55033
db: uniprot

CD28 s37 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD28
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F3S0 378
xref: PTHR10048:SF33
organism: Macaca mulatta

HOMODIMER ID 85STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 eta
stoichiometric coefficient: 2.0

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot Q62925 54
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__TCR_responsive_genes-RIGHT__TCR_responsive_genes-_re62
control type: ACTIVATION
controller: NF-AT

uniprot O43639 269
type: UnificationXref
id: O43639
db: uniprot

uniprot Q29RC5 426
type: UnificationXref
id: Q29RC5
db: uniprot

Y TCR zeta s44 sa45 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s44 sa45 rs6 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=4.644304929068502

PARTICIPANT STOICHIOMETRY r81 754
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot A0A1D5QKD3 232
organism: Macaca mulatta

PTHR45818:SF2
type: RelationshipXref
id: PTHR45818:SF2
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r81 753
type: Stoichiometry
physical entity: PIP
stoichiometric coefficient: 1.0

PTHR45818:SF1
type: RelationshipXref
id: PTHR45818:SF1
db: PANTHER Family
relationship type: By Homology

T ERK s249 a404 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T ERK s249 a404 rs1 T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r81 752
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q9WUA6 493
type: UnificationXref
id: Q9WUA6
db: uniprot

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot Q13153 326
xref: PTHR48015:SF20
organism: Homo sapiens

PTHR45818:SF4
type: RelationshipXref
id: PTHR45818:SF4
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot P48736 404
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot H2PXY8 384
organism: Pan troglodytes

uniprot A5D7R9 154
type: UnificationXref
id: A5D7R9
db: uniprot

CD28 isoform 3
type: ProteinReference
xref: PTHR11494:SF7
xref: uniprot H2QJ99 251
organism: Pan troglodytes

Lck
type: Protein
entity reference: Lck
feature: Y505 Lck s480 a18 rs2
feature: Y394 Lck s480 a18 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7B5L8 514
type: UnificationXref
id: F7B5L8
db: uniprot

ncbitaxon 418459 119
type: UnificationXref
id: 418459
db: ncbitaxon

Gads
type: Protein
entity reference: Gads
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 sa78 597
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

B7
type: ProteinReference
xref: P01337
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.B7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: B7 Synonym: Synonym not specified Accession: P01337
member entity reference: T-lymphocyte activation antigen CD86
member entity reference: T-lymphocyte activation antigen CD80
member entity reference: Uncharacterized protein
member entity reference: CD80 isoform 1
member entity reference: CD86 isoform 3
member entity reference: B7-2 protein
member entity reference: B7-1 protein
member entity reference: CD80 antigen, isoform CRA_a
member entity reference: CD86 molecule

Y171 LAT s76 sa74 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y171
feature location: Y171 LAT s76 sa74 rs3 Y171
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7720410517750427
comment: MODIFICATION_RESIDUE_NAME=Y171

T-cell surface glycoprotein CD3 epsilon chain
type: ProteinReference
xref: uniprot P22646 80
xref: PTHR10570:SF9
organism: Mus musculus

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 182

Transcription factor AP-1
type: ProteinReference
xref: uniprot P05412 505
xref: PTHR11462:SF8
organism: Homo sapiens

uniprot E2RCV1 361
type: UnificationXref
id: E2RCV1
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P27986 399
organism: Homo sapiens

uniprot O75914 322
type: UnificationXref
id: O75914
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot H9FYU7 179
organism: Macaca mulatta

Y226 LAT s97 sa101 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y226
feature location: Y226 LAT s97 sa101 rs5 Y226
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.5851730116547973
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y226

SLP-76
type: ProteinReference
xref: P01321
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.SLP-76
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Lymphocyte cytosolic protein 2
member entity reference: LCP2 isoform 1

SLP-76
type: Protein
entity reference: SLP-76
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 sa104 581
feature: Y SLP 76 s100 sa104 rs3
feature: Y SLP 76 s100 sa104 rs2
feature: Y SLP 76 s100 sa104 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Calcineurin-RIGHT__Calcineurin-_r48
controller: Complex (Calmodulin/Ca++/ Ca++)

Complex (LAT/Gads/ SLP-76/vav/ nck)
type: Complex
component stoichiometry: LAT s104 sa108 STOICHIOMETRY ID COMPLEX
component stoichiometry: vav s107 sa111 STOICHIOMETRY ID COMPLEX
component stoichiometry: nck s108 sa112 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gads s105 sa109 STOICHIOMETRY ID COMPLEX
component stoichiometry: SLP 76 s106 sa110 STOICHIOMETRY ID COMPLEX
component: SLP-76
component: nck
component: vav
component: LAT
component: Gads
feature: COMPLEX BINDING FEATURE s477 a764 544
feature: COMPLEX BINDING FEATURE s477 a764 536
feature: COMPLEX BINDING FEATURE s477 a764 542
feature: COMPLEX BINDING FEATURE s477 a764 540
feature: COMPLEX BINDING FEATURE s477 a764 538
cellular location: cytosol

vav
type: Protein
entity reference: vav
feature: COMPLEX PARTICIPANT BINDING FEATURE s102 sa106 585
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r106
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r106 844
participant stoichiometry: PARTICIPANT STOICHIOMETRY r106 845
left: Ca++
interaction type: STATE_TRANSITION
right: Ca++

Complex (TCR Beta/MHC-antigen/ CD3 gamma/TCR alpha/ CD3 eta/CD3 delta/ TCR zeta)
type: Complex
component stoichiometry: HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
component stoichiometry: CD3 delta s50 sa51 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 84STOICHIOMETRY ID COMPLEX
component stoichiometry: CD3 gamma s47 sa48 STOICHIOMETRY ID COMPLEX
component stoichiometry: MHC antigen s46 sa47 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCR Beta s45 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCR alpha s48 sa49 STOICHIOMETRY ID COMPLEX
component: CD3 delta
component: TCR alpha
component: CD3 eta
component: TCR Beta
component: TCR zeta
component: CD3 gamma
component: MHC -antigen
feature: COMPLEX BINDING FEATURE s370 a615 746
feature: COMPLEX BINDING FEATURE s370 a615 740
feature: COMPLEX BINDING FEATURE s370 a615 742
feature: COMPLEX BINDING FEATURE s370 a615 738
feature: COMPLEX BINDING FEATURE s370 a615 736
feature: COMPLEX BINDING FEATURE s370 a615 744
feature: COMPLEX BINDING FEATURE s370 a615 734
cellular location: cytosol

uniprot P42337 402
type: UnificationXref
id: P42337
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

CD3 eta s72 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 eta
stoichiometric coefficient: 2.0

uniprot P45984 518
type: UnificationXref
id: P45984
db: uniprot

Guanine nucleotide exchange factor VAV2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot P52735 33
organism: Homo sapiens

Calcineurin
type: ProteinReference
xref: P01315
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Calcineurin
comment: ENTITY_REFERENCE_NOTES= Long Name: Calcineurin Synonym: Synonym not specified Accession: P01315
member entity reference: Serine/threonine-protein phosphatase
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

y CD3 gamma s69 sa67 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 gamma s69 sa67 rs1 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=3.784784172784049

STATE_TRANSITION_LEFT__ATP-_Lck-RIGHT__ADP-_Lck-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 758
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 759
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 756
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 757
left: Lck
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: Lck

fos
type: Protein
entity reference: fos
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F7HE20 38
type: UnificationXref
id: F7HE20
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NF_AT-RIGHT__NF_AT-_Pi-_r50
controller: Calcineurin

STATE_TRANSITION_LEFT__ATP-_Lck-RIGHT__ADP-_Lck-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 761
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 760
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 763
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 762
left: Lck
left: ATP
interaction type: STATE_TRANSITION
right: Lck
right: ADP

CD28
type: ProteinReference
xref: P01313
comment: ENTITY_REFERENCE_NOTES= Long Name: CD28 Synonym: Synonym not specified Accession: P01313
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.CD28
member entity reference: CD28 molecule
member entity reference: T-cell-specific surface glycoprotein CD28
member entity reference: CD28
member entity reference: CD28 isoform 3
member entity reference: T-cell-specific surface glycoprotein CD28 homolog

Predicted protein
type: ProteinReference
xref: uniprot A9S9L5 106
organism: Physcomitrella patens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7FHD1 66
xref: PTHR24055:SF203
organism: Monodelphis domestica

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__TCR_responsive_genes-RIGHT__TCR_responsive_genes-_re62
control type: ACTIVATION
controller: NF-kappa B

T ERK s236 a379 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T ERK s236 a379 rs1 T
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A1D5QE27 350
type: UnificationXref
id: A0A1D5QE27
db: uniprot

y CD3 delta s71 sa69 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 delta s71 sa69 rs1 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8870116001312134
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y

y CD3 gamma s69 sa67 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 gamma s69 sa67 rs2 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.42102100526642
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y

uniprot F1MYM3 365
type: UnificationXref
id: F1MYM3
db: uniprot

uniprot P41240 96
type: UnificationXref
id: P41240
db: uniprot

DISSOCIATION
type: InteractionVocabulary

HETERODIMER_ASSOCIATION_LEFT__MEK-_Complex__Ras_GTP__Raf_-RIGHT__Complex__Ras_GTP__Raf_MEK_-_r101
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 869
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 871
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 870
left: MEK
left: Complex (Ras/GTP/ Raf)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Ras/GTP/ Raf/MEK)

Complex (LAT/SLP-76/ Grb2/SOS/ Gads/PLC-gamma)
type: Complex
component stoichiometry: Grb2 s78 sa76 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gads s80 sa78 STOICHIOMETRY ID COMPLEX
component stoichiometry: SLP 76 s77 sa75 STOICHIOMETRY ID COMPLEX
component stoichiometry: PLC gamma s81 sa79 STOICHIOMETRY ID COMPLEX
component stoichiometry: LAT s76 sa74 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s79 sa77 STOICHIOMETRY ID COMPLEX
component: PLC-gamma
component: LAT
component: SOS
component: SLP-76
component: Grb2
component: Gads
feature: COMPLEX BINDING FEATURE s442 a682 594
feature: COMPLEX BINDING FEATURE s442 a682 590
feature: COMPLEX BINDING FEATURE s442 a682 588
feature: COMPLEX BINDING FEATURE s442 a682 596
feature: COMPLEX BINDING FEATURE s442 a682 592
feature: COMPLEX BINDING FEATURE s442 a682 598
cellular location: cytosol

y CD3 delta s42 sa43 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 delta s42 sa43 rs2 y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=2.412924694611101

PARTICIPANT STOICHIOMETRY r105 848
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r105 849
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

y CD3 delta s71 sa69 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 delta s71 sa69 rs2 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=2.412924694611101

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 231
xref: uniprot Q99N57 230
xref: PTHR44329:SF22
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r111
controller: PLC-gamma

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 29

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: uniprot O00459 389
xref: PTHR10155:SF1
organism: Homo sapiens

LAT s66 sa98 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LAT
stoichiometric coefficient: 1.0

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa17 707
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

y CD3 delta s42 sa43 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 delta s42 sa43 rs1 y
comment: MODIFICATION_RESIDUE_ANGLE=3.8870116001312134
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y

uniprot P27597 81
type: UnificationXref
id: P27597
db: uniprot

uniprot Q6GL60 429
type: UnificationXref
id: Q6GL60
db: uniprot

PARTICIPANT STOICHIOMETRY r50 898
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r103
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 854
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 853
left: Ca++
interaction type: TRANSPORT
right: Ca++

Y191 LAT s76 sa74 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y191
feature location: Y191 LAT s76 sa74 rs4 Y191
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y191
comment: MODIFICATION_RESIDUE_ANGLE=5.800300360425278

PARTICIPANT STOICHIOMETRY r50 896
type: Stoichiometry
physical entity: NF-AT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r50 897
type: Stoichiometry
physical entity: NF-AT
stoichiometric coefficient: 1.0

Ca++
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6Y4G8 512
organism: Canis lupus familiaris

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot Q60680 459
organism: Mus musculus

uniprot Q91974 420
type: UnificationXref
id: Q91974
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q1HG70 245
organism: Canis lupus familiaris

uniprot P79996 520
type: UnificationXref
id: P79996
db: uniprot

uniprot E2REI6 214
type: UnificationXref
id: E2REI6
db: uniprot

uniprot B0BLZ8 279
type: UnificationXref
id: B0BLZ8
db: uniprot

PI3K
type: Protein
entity reference: PI3K
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pak
type: Protein
entity reference: Pak
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y191 LAT s406 a275 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y191
feature location: Y191 LAT s406 a275 rs4 Y191
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y191
comment: MODIFICATION_RESIDUE_ANGLE=5.800300360425278

PARTICIPANT STOICHIOMETRY r37 784
type: Stoichiometry
physical entity: Complex (cdc42/GDP)
stoichiometric coefficient: 1.0

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

uniprot Q1HG70 245
type: UnificationXref
id: Q1HG70
db: uniprot

PARTICIPANT STOICHIOMETRY r37 787
type: Stoichiometry
physical entity: Complex (cdc42/GTP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 786
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 785
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

NF kappa B s29 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NF-kappa B
stoichiometric coefficient: 1.0

uniprot Q60680 459
type: UnificationXref
id: Q60680
db: uniprot

T-lymphocyte activation antigen CD80
type: ProteinReference
xref: uniprot P33681 530
xref: PTHR25466:SF4
organism: Homo sapiens

Y SLP 76 s77 sa75 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s77 sa75 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.900215879598692

Ca++
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s87 sa88 661
cellular location: cytosol
comment: SPECIES_TYPE=ION

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

Akt
type: Protein
entity reference: Akt
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa33 677
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y TCR zeta s51 sa52 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s51 sa52 rs1 Y
comment: MODIFICATION_RESIDUE_ANGLE=0.7443253848069942
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

TRANSCRIPTION
type: RelationshipTypeVocabulary

Complex (NF-kappa B/I kappa B)
type: Complex
component stoichiometry: NF kappa B s29 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: I kappa B s30 sa31 STOICHIOMETRY ID COMPLEX
component: I kappa B
component: NF-kappa B
feature: COMPLEX BINDING FEATURE s317 a525 702
feature: COMPLEX BINDING FEATURE s317 a525 700
cellular location: cytosol

uniprot O15111 457
type: UnificationXref
id: O15111
db: uniprot

IP3R
type: Protein
entity reference: IP3R
feature: ACTIVE 5
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Y132 LAT s4 a4 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y132
feature location: Y132 LAT s4 a4 rs2 Y132
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3298847729394225
comment: MODIFICATION_RESIDUE_NAME=Y132

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RGZ2 56
organism: Pan troglodytes

Y SLP 76 s77 sa75 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s77 sa75 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=Y

rac s112 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: rac
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Lymphocyte cytosolic protein 2
type: ProteinReference
xref: PTHR14098:SF1
xref: uniprot E2RRX6 343
organism: Canis lupus familiaris

uniprot F1Q2Q9 366
type: UnificationXref
id: F1Q2Q9
db: uniprot

uniprot A0A0D1DU81 99
type: UnificationXref
id: A0A0D1DU81
db: uniprot

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: uniprot F1QNG4 156
xref: PTHR24070:SF423
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot W4XNQ0 151
xref: PTHR23050:SF414
organism: Strongylocentrotus purpuratus

uniprot Q0VBZ0 98
type: UnificationXref
id: Q0VBZ0
db: uniprot

uniprot Q7QGY7 149
type: UnificationXref
id: Q7QGY7
db: uniprot

Jnk s253 a406 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot A0A2I3T4Q0 449
xref: PTHR22969:SF13
organism: Pan troglodytes

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 197

HOMODIMER ID 87STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 eta
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r54 880
type: Stoichiometry
physical entity: Jnk
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Ca_PLUS__PLUS_-_Calmodulin-RIGHT__Complex__Calmodulin_Ca_PLUS__PLUS___Ca_PLUS__PLUS__-_r104
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 852
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 851
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 850
left: Ca++
left: Calmodulin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Calmodulin/Ca++/ Ca++)

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot A0A3S5ZPX3 233
organism: Bos taurus

TCR Beta
type: Protein
entity reference: TCR Beta
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa42 627
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TCR alpha
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa49 741
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r54 881
type: Stoichiometry
physical entity: Jnk
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F1MYM3 365
organism: Bos taurus

Y110 LAT s66 sa98 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y110
feature location: Y110 LAT s66 sa98 rs1 Y110
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y110
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

PTHR23050:SF427
type: RelationshipXref
id: PTHR23050:SF427
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P10686 338
xref: PTHR10336:SF173
organism: Rattus norvegicus

uniprot P17325 507
type: UnificationXref
id: P17325
db: uniprot

uniprot Q8NEB9 410
type: UnificationXref
id: Q8NEB9
db: uniprot

TCR zeta
type: Complex
component stoichiometry: TCR zeta s44 sa45 STOICHIOMETRY ID COMPLEX
component: TCR zeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa45 633
cellular location: cytosol

PTHR23050:SF424
type: RelationshipXref
id: PTHR23050:SF424
db: PANTHER Family
relationship type: By Homology

TCR zeta
type: Complex
component stoichiometry: TCR zeta s51 sa52 STOICHIOMETRY ID COMPLEX
component: TCR zeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa52 747
cellular location: cytosol

uniprot F1PET4 21
type: UnificationXref
id: F1PET4
db: uniprot

TCR zeta
type: Complex
component stoichiometry: TCR zeta s58 sa59 STOICHIOMETRY ID COMPLEX
component: TCR zeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa59 657
cellular location: cytosol

TCR zeta
type: Complex
component stoichiometry: TCR zeta s63 sa64 STOICHIOMETRY ID COMPLEX
component: TCR zeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa64 729
cellular location: cytosol

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: uniprot F1PET4 21
xref: PTHR45818:SF1
organism: Canis lupus familiaris

uniprot E2QYK5 194
type: UnificationXref
id: E2QYK5
db: uniprot

uniprot F7E823 62
type: UnificationXref
id: F7E823
db: uniprot

TCR zeta
type: Complex
component stoichiometry: TCR zeta s73 sa71 STOICHIOMETRY ID COMPLEX
component: TCR zeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa71 555
cellular location: cytosol

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Lck-RIGHT__Lck-_Pi-_r4
controller: CD45

uniprot O88643 323
type: UnificationXref
id: O88643
db: uniprot

PTHR23050:SF438
type: RelationshipXref
id: PTHR23050:SF438
db: PANTHER Family
relationship type: By Homology

ncbitaxon 3702 138
type: UnificationXref
id: 3702
db: ncbitaxon

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot K7AWV1 94
xref: PTHR24418:SF407
organism: Pan troglodytes

ncbitaxon 6238 105
type: UnificationXref
id: 6238
db: ncbitaxon

PLC gamma s94 sa95 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot Q63788 405
type: UnificationXref
id: Q63788
db: uniprot

STATE_TRANSITION_LEFT__Complex__cdc42_GDP_-_GTP-RIGHT__GDP-_Complex__cdc42_GTP_-_r37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 785
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 786
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 784
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 787
left: Complex (cdc42/GDP)
left: GTP
interaction type: STATE_TRANSITION
right: GDP
right: Complex (cdc42/GTP)

uniprot P31749 487
type: UnificationXref
id: P31749
db: uniprot

uniprot W4YPT6 153
type: UnificationXref
id: W4YPT6
db: uniprot

SLP 76 s92 sa93 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SLP-76
stoichiometric coefficient: 1.0

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s113 sa11 715
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r102 860
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Y191 LAT s104 sa108 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y191
feature location: Y191 LAT s104 sa108 rs4 Y191
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y191
comment: MODIFICATION_RESIDUE_ANGLE=5.800300360425278

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot P28028 227
xref: PTHR44329:SF47
organism: Mus musculus

y CD3 gamma s55 sa56 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 gamma s55 sa56 rs1 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=3.784784172784049

uniprot F6WV79 511
type: UnificationXref
id: F6WV79
db: uniprot

y CD3 eta s72 sa70 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 eta s72 sa70 rs1 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=3.91785828020355

T-lymphocyte activation antigen CD80
type: ProteinReference
xref: PTHR25466:SF4
xref: uniprot Q00609 533
organism: Mus musculus

GDP s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r102 859
type: Stoichiometry
physical entity: Complex (Ras/GTP/ Raf)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r102 858
type: Stoichiometry
physical entity: Complex (Ras/GTP/ Raf/MEK)
stoichiometric coefficient: 1.0

uniprot F1PHV7 155
type: UnificationXref
id: F1PHV7
db: uniprot

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot Q28EW2 163
xref: PTHR24070:SF423
organism: Xenopus tropicalis

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

uniprot Q9WTQ0 306
type: UnificationXref
id: Q9WTQ0
db: uniprot

uniprot F7BZL6 375
type: UnificationXref
id: F7BZL6
db: uniprot

Complex (PIP2/Akt)
type: Complex
component stoichiometry: Akt s32 sa33 STOICHIOMETRY ID COMPLEX
component stoichiometry: PIP2 s31 sa32 STOICHIOMETRY ID COMPLEX
component: Akt
component: PIP2
feature: COMPLEX BINDING FEATURE s334 a560 676
feature: COMPLEX BINDING FEATURE s334 a560 674
cellular location: cytosol

Y110 LAT s104 sa108 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y110
feature location: Y110 LAT s104 sa108 rs1 Y110
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y110
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7BAS2 317
xref: PTHR48015:SF30
organism: Ornithorhynchus anatinus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MYJ4 476
xref: PTHR24356:SF190
organism: Bos taurus

TCR Beta s52 sa53 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR Beta
stoichiometric coefficient: 1.0

y CD3 eta s72 sa70 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 eta s72 sa70 rs2 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=2.412924694611101

Y226 LAT s89 sa90 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y226
feature location: Y226 LAT s89 sa90 rs5 Y226
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.5851730116547973
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y226

y CD3 gamma s55 sa56 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 gamma s55 sa56 rs2 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.42102100526642
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y

C-fos
type: ProteinReference
xref: uniprot A5A6H0 192
xref: PTHR23351:SF4
organism: Pan troglodytes

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

CD28
type: Protein
entity reference: CD28
feature: ACTIVE 5
feature: Y CD28 s37 sa38 rs1

PTHR23050:SF414
type: RelationshipXref
id: PTHR23050:SF414
db: PANTHER Family
relationship type: By Homology

uniprot P16333 271
type: UnificationXref
id: P16333
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot E2RJX4 474
organism: Canis lupus familiaris

C-fos
type: ProteinReference
xref: uniprot A5A6H2 193
xref: PTHR23351:SF4
organism: Macaca mulatta

Y226 LAT s406 a275 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y226
feature location: Y226 LAT s406 a275 rs5 Y226
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.5851730116547973
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y226

uniprot Q07890 184
type: UnificationXref
id: Q07890
db: uniprot

uniprot Q92569 411
type: UnificationXref
id: Q92569
db: uniprot

I kappa B
type: ProteinReference
xref: P01323
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: I kappa B Synonym: IkB,inhibitor of NF-kappa B Accession: P01323
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.I kappa B
member entity reference: NFKB inhibitor alpha
member entity reference: NF-kappa-B inhibitor alpha
member entity reference: Uncharacterized protein
member entity reference: NF kappa B inhibitor alpha (Fragment)

Leishmania major
type: BioSource
xref: ncbitaxon 5664 146

PTHR10035:SF2
type: RelationshipXref
id: PTHR10035:SF2
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot H2QNG6 386
xref: PTHR10048:SF33
organism: Pan troglodytes

Guanine nucleotide exchange factor VAV3
type: ProteinReference
xref: uniprot Q9UKW4 36
xref: PTHR45818:SF1
organism: Homo sapiens

uniprot F6SEH5 284
type: UnificationXref
id: F6SEH5
db: uniprot

PARTICIPANT STOICHIOMETRY r81 755
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1Q4F8 478
xref: PTHR24356:SF190
organism: Canis lupus familiaris

uniprot A0A1D5R9U8 205
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

uniprot P08575 447
type: UnificationXref
id: P08575
db: uniprot

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

uniprot P04235 439
type: UnificationXref
id: P04235
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF424
xref: uniprot F7CY56 126
organism: Monodelphis domestica

HETERODIMER ASSOCIATION LEFT MHC antigen- Complex CD3 gamma TCR alpha TCR Beta CD3 delta CD3 eta TCR zeta -RIGHT Complex TCR Beta MHC antigen CD3 gamma TCR alpha CD3 eta CD3 delta TCR zeta - r95
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 830
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 829
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 831
left: MHC -antigen
left: Complex (CD3 gamma/TCR alpha/ TCR Beta/CD3 delta/ CD3 eta/TCR zeta)
display name: HETERODIMER_ASSOCIATION_LEFT__MHC__antigen-_Complex__CD3_gamma_TCR_alpha__TCR_Beta_CD3_delta__CD3_eta_TCR_zeta_-RIGHT__Complex__TCR_Beta_MHC_antigen__CD3_gamma_TCR_alpha__CD3_eta_CD3_delta__TCR_zeta_-_r95
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TCR Beta/MHC-antigen/ CD3 gamma/TCR alpha/ CD3 eta/CD3 delta/ TCR zeta)

uniprot A0A1D5QRB7 436
type: UnificationXref
id: A0A1D5QRB7
db: uniprot

Y171 LAT s104 sa108 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y171
feature location: Y171 LAT s104 sa108 rs3 Y171
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7720410517750427
comment: MODIFICATION_RESIDUE_NAME=Y171

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 8

CD3 eta
type: Complex
component stoichiometry: CD3 eta s43 sa44 STOICHIOMETRY ID COMPLEX
component: CD3 eta
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa44 631
cellular location: cytosol

CD3 eta
type: Complex
component stoichiometry: CD3 eta s57 sa58 STOICHIOMETRY ID COMPLEX
component: CD3 eta
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa58 655
cellular location: cytosol

IP3R
type: Protein
entity reference: IP3R
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

CD3 eta
type: Complex
component stoichiometry: CD3 eta s49 sa50 STOICHIOMETRY ID COMPLEX
component: CD3 eta
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa50 743
cellular location: cytosol

CD3 eta
type: Complex
component stoichiometry: CD3 eta s72 sa70 STOICHIOMETRY ID COMPLEX
component: CD3 eta
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 sa70 553
cellular location: cytosol

CD3 eta
type: Complex
component stoichiometry: CD3 eta s62 sa63 STOICHIOMETRY ID COMPLEX
component: CD3 eta
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa63 727
cellular location: cytosol

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q04759 305
organism: Homo sapiens

Gads
type: Protein
entity reference: Gads
feature: COMPLEX PARTICIPANT BINDING FEATURE s105 sa109 539
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q28073 82
type: UnificationXref
id: Q28073
db: uniprot

Y SLP 76 s77 sa75 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s77 sa75 rs3 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=2.3201360379273255

uniprot P45983 517
type: UnificationXref
id: P45983
db: uniprot

uniprot F6W3Y0 315
type: UnificationXref
id: F6W3Y0
db: uniprot

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot Q13177 327
organism: Homo sapiens

uniprot P25963 417
type: UnificationXref
id: P25963
db: uniprot

uniprot Q6PI52 148
type: UnificationXref
id: Q6PI52
db: uniprot

CD3 delta
type: Protein
entity reference: CD3 delta
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa51 745
feature: y CD3 delta s50 sa51 rs2
feature: y CD3 delta s50 sa51 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q02384 181
type: UnificationXref
id: Q02384
db: uniprot

y CD3 gamma s39 sa40 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 gamma s39 sa40 rs2 y
comment: MODIFICATION_RESIDUE_ANGLE=2.42102100526642
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y

uniprot P24161 41
type: UnificationXref
id: P24161
db: uniprot

ZAP-70
type: Protein
entity reference: ZAP-70
feature: Y ZAP 70 s486 a373 rs1
feature: ACTIVE 5
feature: Y ZAP 70 s486 a373 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

LCP2 isoform 1
type: ProteinReference
xref: PTHR14098:SF1
xref: uniprot A0A2I3S4L7 341
organism: Pan troglodytes

uniprot P0DP29 136
type: UnificationXref
id: P0DP29
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 219
xref: PTHR44329:SF22
xref: uniprot P04049 218
organism: Homo sapiens

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa19 571
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Y TCR zeta s63 sa64 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s63 sa64 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7443253848069942
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Ca PLUS PLUS s87 sa88 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YJC1 422
organism: Branchiostoma floridae

CD3 delta s71 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 delta
stoichiometric coefficient: 1.0

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

SLP 76 s100 sa104 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SLP-76
stoichiometric coefficient: 1.0

Y394 Lck s499 a653 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y394
feature location: Y394 Lck s499 a653 rs1 Y394
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y394
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.02

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P79996 520
xref: PTHR24055:SF172
organism: Gallus gallus

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot Q64303 330
organism: Rattus norvegicus

ncbitaxon 81824 110
type: UnificationXref
id: 81824
db: ncbitaxon

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: uniprot F1Q2Q9 366
xref: PTHR10155:SF3
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__MEKK-RIGHT__MEKK-_re61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 883
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 882
left: MEKK
interaction type: STATE_TRANSITION
right: MEKK

Y SLP 76 s2 sa2 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s2 sa2 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.900215879598692

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63001 424
organism: Mus musculus

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63000 423
organism: Homo sapiens

uniprot P04627 220
type: UnificationXref
id: P04627
db: uniprot

Y TCR zeta s63 sa64 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s63 sa64 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.3576366636899095
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Y171 LAT s93 sa94 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y171
feature location: Y171 LAT s93 sa94 rs3 Y171
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7720410517750427
comment: MODIFICATION_RESIDUE_NAME=Y171

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r103
control type: ACTIVATION
controller: CRAC

ncbitaxon 10116 15
type: UnificationXref
id: 10116
db: ncbitaxon

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

uniprot Q61411 166
type: UnificationXref
id: Q61411
db: uniprot

uniprot F7C1G6 344
type: UnificationXref
id: F7C1G6
db: uniprot

uniprot A0A3Q2U4X3 473
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

Y SLP 76 s2 sa2 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s2 sa2 rs3 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=2.3201360379273255

Calmodulin
type: Protein
entity reference: Calmodulin
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 sa87 659
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A2I3T9Y4 471
xref: PTHR24356:SF190
organism: Pan troglodytes

uniprot F7HC75 303
type: UnificationXref
id: F7HC75
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Actin polymerization
controller: Complex (cdc42/GTP/ WASP)

PARTICIPANT STOICHIOMETRY r68 797
type: Stoichiometry
physical entity: IKK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 796
type: Stoichiometry
physical entity: IKK
stoichiometric coefficient: 1.0

CD3 eta
type: ProteinReference
xref: P01302
standard name: CD3 epsilon
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.CD3_br_eta
comment: ENTITY_REFERENCE_NOTES=
member entity reference: T-cell surface glycoprotein CD3 epsilon chain
member entity reference: CD3E isoform 2
member entity reference: Uncharacterized protein

Cytoplasmic protein NCK2
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot O43639 269
organism: Homo sapiens

B7-2 protein
type: ProteinReference
xref: PTHR25466:SF2
xref: uniprot Q9TTF2 535
organism: Canis lupus familiaris

uniprot Q6DGB7 428
type: UnificationXref
id: Q6DGB7
db: uniprot

PTHR25466:SF2
type: RelationshipXref
id: PTHR25466:SF2
db: PANTHER Family
relationship type: By Homology

PIP3
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa34 709
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

vav
type: Protein
entity reference: vav
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P48453 290
type: UnificationXref
id: P48453
db: uniprot

PTHR25466:SF4
type: RelationshipXref
id: PTHR25466:SF4
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot Q14643 470
organism: Homo sapiens

uniprot P63328 293
type: UnificationXref
id: P63328
db: uniprot

ZAP 70 s64 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ZAP-70
stoichiometric coefficient: 1.0

uniprot P29994 469
type: UnificationXref
id: P29994
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot O77628 196
organism: Bos taurus

Transcription factor AP-1
type: ProteinReference
xref: uniprot O77627 504
xref: PTHR11462:SF8
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PIP2-RIGHT__ADP-_PIP3-_r82
controller: PI3K

uniprot H2R5K3 51
type: UnificationXref
id: H2R5K3
db: uniprot

uniprot Q9UKW4 36
type: UnificationXref
id: Q9UKW4
db: uniprot

STATE_TRANSITION_LEFT__NF_AT-RIGHT__NF_AT-_Pi-_r50
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 898
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 896
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 897
left: NF-AT
interaction type: STATE_TRANSITION
right: NF-AT
right: Pi

uniprot P43403 190
type: UnificationXref
id: P43403
db: uniprot

uniprot Q08E52 325
type: UnificationXref
id: Q08E52
db: uniprot

uniprot P11345 223
type: UnificationXref
id: P11345
db: uniprot

LAT s89 sa90 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LAT
stoichiometric coefficient: 1.0

Cytoplasmic protein
type: ProteinReference
xref: uniprot G2HHN0 267
xref: PTHR19969:SF16
organism: Pan troglodytes

uniprot F6X927 453
type: UnificationXref
id: F6X927
db: uniprot

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot Q08209 295
organism: Homo sapiens

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot F7ALW1 264
organism: Monodelphis domestica

uniprot F7AN37 442
type: UnificationXref
id: F7AN37
db: uniprot

uniprot H2QKD0 336
type: UnificationXref
id: H2QKD0
db: uniprot

uniprot A0A2I3SSC7 463
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot Q95KV0 460
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r113 803
type: Stoichiometry
physical entity: Complex (LAT/Pak/ Gads/SLP-76/ WASP/vav/ nck)
stoichiometric coefficient: 1.0

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot Q95KV1 461
xref: PTHR22969:SF13
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r24 864
type: Stoichiometry
physical entity: Complex (Ras/GTP)
stoichiometric coefficient: 1.0

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF369
xref: uniprot A0A0R4J8U1 186
organism: Rattus norvegicus

T cell activation
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Pak-_Complex__LAT_Gads__SLP_76_-_vav-_WASP-_nck-RIGHT__Complex__LAT_Pak__Gads_SLP_76__WASP_vav__nck_-_r113
pathway component: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r28
pathway component: STATE_TRANSITION_LEFT__ATP-_Lck-RIGHT__ADP-_Lck-_r7
pathway component: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r68
pathway component: STATE_TRANSITION_LEFT__Calcineurin-RIGHT__Calcineurin-_r48
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r115
pathway component: TRANSPORT_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r103
pathway component: DISSOCIATION_LEFT__Complex__NF_kappa_B_I_kappa_B_-RIGHT__NF_kappa_B-_I_kappa_B-_r67
pathway component: STATE_TRANSITION_LEFT__CRAC-RIGHT__CRAC-_r46
pathway component: STATE_TRANSITION_LEFT__MEKK-RIGHT__MEKK-_re61
pathway component: STATE TRANSITION LEFT ATP- Complex TCR Beta MHC antigen CD3 gamma TCR alpha CD3 eta CD3 delta TCR zeta -RIGHT ADP- Complex TCR Beta MHC antigen TCR alpha CD3 gamma CD3 delta CD3 eta TCR zeta - r96
pathway component: HETERODIMER_ASSOCIATION_LEFT__Raf-_Complex__Ras_GTP_-RIGHT__Complex__Ras_GTP__Raf_-_r25
pathway component: STATE_TRANSITION_LEFT__ATP-_PIP2-RIGHT__ADP-_PIP3-_r82
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r111
pathway component: HETERODIMER_ASSOCIATION_LEFT__Ca_PLUS__PLUS_-_Calmodulin-RIGHT__Complex__Calmodulin_Ca_PLUS__PLUS___Ca_PLUS__PLUS__-_r104
pathway component: STATE_TRANSITION_LEFT__Complex__Ras_GDP__-_GTP-RIGHT__GDP-_Complex__Ras_GTP_-_r24
pathway component: STATE_TRANSITION_LEFT__Complex__cdc42_GDP_-_GTP-RIGHT__GDP-_Complex__cdc42_GTP_-_r37
pathway component: STATE_TRANSITION_LEFT__NF_AT-RIGHT__NF_AT-_Pi-_r50
pathway component: STATE_TRANSITION_LEFT__LAT-RIGHT__LAT-_r16
pathway component: TRANSPORT_LEFT__Jnk-RIGHT__Jnk-_r91
pathway component: STATE_TRANSITION_LEFT__ATP-_Complex__TCR_Beta_CD3_gamma__CD3_delta_CD3_eta__TCR_zeta_ZAP_70__TCR_alpha_-RIGHT__ADP-_Complex__CD3_gamma_TCR_Beta__CD3_delta_CD3_eta__TCR_zeta_ZAP_70__TCR_alpha_-_r99
pathway component: TRANSPORT_LEFT__NF_AT-RIGHT__NF_AT-_r93
pathway component: STATE_TRANSITION_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r106
pathway component: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r105
pathway component: TRANSCRIPTION_LEFT__TCR_responsive_genes-RIGHT__TCR_responsive_genes-_re62
pathway component: STATE_TRANSITION_LEFT__ATP-_PIP-RIGHT__ADP-_PIP2-_r81
pathway component: MODULATION
pathway component: DISSOCIATION_LEFT__Complex__Ras_GTP__Raf_MEK_-RIGHT__Complex__Ras_GTP__Raf_-_MEK-_r102
pathway component: TRANSPORT_LEFT__ERK-RIGHT__ERK-_r94
pathway component: DISSOCIATION_LEFT__Complex__LAT_Pak__Gads_SLP_76__WASP_vav__nck_-RIGHT__Pak-_Complex__LAT_Gads__SLP_76_vav__nck_-_WASP-_r114
pathway component: STATE_TRANSITION_LEFT__ATP-_Complex__CD28_B7_-RIGHT__ADP-_Complex__CD28_B7_-_r88
pathway component: TRANSPORT_LEFT__NF_kappa_B-RIGHT__NF_kappa_B-_r92
pathway component: STATE_TRANSITION_LEFT__Complex__rac_GDP_-_GTP-RIGHT__GDP-_Complex__rac_GTP_-_r36
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__cdc42_GTP_-_WASP-RIGHT__Complex__cdc42_GTP__WASP_-_r39
pathway component: STATE_TRANSITION_LEFT__ATP-_Lck-RIGHT__ADP-_Lck-_r5
pathway component: STATE_TRANSITION_LEFT__Jnk-RIGHT__Jnk-_r54
pathway component: HETERODIMER_ASSOCIATION_LEFT__PIP3-_Akt-RIGHT__Complex__PIP3_Akt_-_r112
pathway component: HETERODIMER_ASSOCIATION_LEFT__CD28-_B7-RIGHT__Complex__CD28_B7_-_r87
pathway component: DISSOCIATION_LEFT__Complex__LAT_PLC_gamma__Gads_SLP_76_-RIGHT__Complex__LAT_Gads__SLP_76_-_PLC_gamma-_r110
pathway component: HETERODIMER ASSOCIATION LEFT ZAP 70- Complex TCR Beta MHC antigen TCR alpha CD3 gamma CD3 delta CD3 eta TCR zeta -RIGHT Complex TCR Beta CD3 gamma CD3 delta CD3 eta TCR zeta ZAP 70 TCR alpha - r98
pathway component: STATE_TRANSITION_LEFT__ATP-_Complex__LAT_PLC_gamma__Gads_SLP_76_-RIGHT__ADP-_Complex__LAT_PLC_gamma__Gads_SLP_76_-_r107
pathway component: HETERODIMER_ASSOCIATION_LEFT__PIP2-_Akt-RIGHT__Complex__PIP2_Akt_-_r83
pathway component: HETERODIMER ASSOCIATION LEFT MHC antigen- Complex CD3 gamma TCR alpha TCR Beta CD3 delta CD3 eta TCR zeta -RIGHT Complex TCR Beta MHC antigen CD3 gamma TCR alpha CD3 eta CD3 delta TCR zeta - r95
pathway component: STATE_TRANSITION_LEFT__MEKK-RIGHT__MEKK-_r85
pathway component: STATE_TRANSITION_LEFT__Lck-RIGHT__Lck-_Pi-_r4
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__SOS_Grb2_-_LAT-_Complex__Gads_SLP_76_-_PLC_gamma-RIGHT__Complex__LAT_SLP_76__Grb2_SOS__Gads_PLC_gamma_-_r100
pathway component: HETERODIMER_ASSOCIATION_LEFT__Pak-_Complex__rac_GTP_-RIGHT__Complex__rac_GTP__Pak_-_r38
pathway component: HETERODIMER_ASSOCIATION_LEFT__MEK-_Complex__Ras_GTP__Raf_-RIGHT__Complex__Ras_GTP__Raf_MEK_-_r101
pathway component: HETERODIMER_ASSOCIATION_LEFT__PKC_theta-_DAG-RIGHT__Complex__DAG_PKC_theta_-_r45
pathway component: STATE_TRANSITION_LEFT__jun-_ATP-RIGHT__jun-_ADP-_r52
pathway component: HETERODIMER_ASSOCIATION_LEFT__fos-_jun-RIGHT__Complex__jun_fos_-_r53
pathway component: STATE_TRANSITION_LEFT__CD45-RIGHT__CD45-_r97
xref: PANTHER Pathway P00053 1
comment: MODEL_NOTES=Panther Pathway: P00053 T cell activation refers to a process in which mature T cells, which express antigen-specific T cell receptors on their surfaces, recognize their cognate antigens and respond by entering the cell cycle, secreting cytokines or lytic enzymes, and initiating the cell-based functions of the immune system. T cell signaling involves a complex network of biochemical interactions, most of which are initiated downstream of the TCR itself, but a few of which can be induced by accessory receptors. TCR signaling requires close interactions between the T cell and an antigen presenting cell, and as a result involve extensive coordination between TCR signaling networks and both cytoskeletal and membrane dynamic processes. Medline=10781399 Medline=10781404 Medline=15001169 PMID: 10781399 PMID: 10781404 PMID: 15001169

Uncharacterized protein
type: ProteinReference
xref: PTHR45818:SF1
xref: uniprot F7EJL2 24
organism: Monodelphis domestica

jun
type: ProteinReference
xref: P01335
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: jun Synonym: Synonym not specified Accession: P01335
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.jun
member entity reference: Transcription factor AP-1

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 11

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: uniprot Q8CIN4 332
xref: PTHR48015:SF22
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r24 863
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 862
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 861
type: Stoichiometry
physical entity: Complex (Ras/GDP )
stoichiometric coefficient: 1.0

uniprot F6R8N3 481
type: UnificationXref
id: F6R8N3
db: uniprot

Y TCR zeta s63 sa64 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s63 sa64 rs5 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.278337656950498
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Lck
type: ProteinReference
xref: P01310
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Lck Synonym: Lymphocyte-specific c-src family protein tyrosine kinase Accession: P01310
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Lck
member entity reference: Proto-oncogene tyrosine-protein kinase LCK
member entity reference: Tyrosine-protein kinase Lck
member entity reference: Tyrosine-protein kinase

HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR zeta
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 207
evidence: Evidence 209
evidence: Evidence 206
evidence: Evidence 208
xref: uniprot A0A1D5R9U8 205
xref: PTHR44329:SF22
organism: Macaca mulatta

HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR zeta
stoichiometric coefficient: 2.0

jun s302 a500 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: PTHR25466:SF2
xref: uniprot F6R7U3 525
organism: Macaca mulatta

ncbitaxon 7227 141
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot F7DKU1 286
type: UnificationXref
id: F7DKU1
db: uniprot

uniprot P20963 40
type: UnificationXref
id: P20963
db: uniprot

TCR Beta s59 sa60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR Beta
stoichiometric coefficient: 1.0

Y TCR zeta s63 sa64 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s63 sa64 rs6 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=4.644304929068502

Akt
type: Protein
entity reference: Akt
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa35 711
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TCR zeta s51 sa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR zeta
stoichiometric coefficient: 2.0

LAT
type: Protein
entity reference: LAT
feature: Y110 LAT s104 sa108 rs1
feature: Y171 LAT s104 sa108 rs3
feature: Y226 LAT s104 sa108 rs5
feature: COMPLEX PARTICIPANT BINDING FEATURE s104 sa108 537
feature: Y191 LAT s104 sa108 rs4
feature: Y132 LAT s104 sa108 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q14643 470
type: UnificationXref
id: Q14643
db: uniprot

IP3R
type: ProteinReference
xref: P01331
standard name: inositol 1,4,5-triphosphate receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.ION_CHANNEL.IP3R
comment: ENTITY_REFERENCE_NOTES= Long Name: IP3R Synonym: IP3 Receptor Accession: P01331
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: Uncharacterized protein
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1 isoform 3

uniprot E2RH85 362
type: UnificationXref
id: E2RH85
db: uniprot

y CD3 gamma s60 sa61 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 gamma s60 sa61 rs1 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=3.784784172784049

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot E2RNA9 451
xref: PTHR22969:SF13
organism: Canis lupus familiaris

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 224
xref: uniprot P11345 223
xref: PTHR44329:SF22
organism: Rattus norvegicus

uniprot A0A1D5Q5Z6 57
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

eco ECO:0000304 197
type: UnificationXref
id: ECO:0000304
db: eco

uniprot F6VXG1 372
type: UnificationXref
id: F6VXG1
db: uniprot

Y TCR zeta s63 sa64 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s63 sa64 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=6.2116579744416045
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

PLC gamma s81 sa79 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

uniprot H2QJ99 251
type: UnificationXref
id: H2QJ99
db: uniprot

Akt s32 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot D4A3M8 261
organism: Rattus norvegicus

uniprot P08487 337
type: UnificationXref
id: P08487
db: uniprot

uniprot F6SZ66 369
type: UnificationXref
id: F6SZ66
db: uniprot

uniprot Q63932 247
type: UnificationXref
id: Q63932
db: uniprot

Akt
type: Protein
entity reference: Akt
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

y CD3 gamma s60 sa61 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 gamma s60 sa61 rs2 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.42102100526642
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y

SLP-76
type: Protein
entity reference: SLP-76
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa100 605
feature: Y SLP 76 s68 sa100 rs1
feature: Y SLP 76 s68 sa100 rs2
feature: Y SLP 76 s68 sa100 rs3
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__CRAC-RIGHT__CRAC-_r46
control type: ACTIVATION
controller: Ca++

PTHR23351:SF4
type: RelationshipXref
id: PTHR23351:SF4
db: PANTHER Family
relationship type: By Homology

y CD3 gamma s39 sa40 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 gamma s39 sa40 rs1 y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=3.784784172784049

uniprot O70167 393
type: UnificationXref
id: O70167
db: uniprot

PARTICIPANT STOICHIOMETRY r113 800
type: Stoichiometry
physical entity: vav
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r113 802
type: Stoichiometry
physical entity: nck
stoichiometric coefficient: 1.0

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q04970 162
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r113 801
type: Stoichiometry
physical entity: WASP
stoichiometric coefficient: 1.0

uniprot H2QIE3 189
type: UnificationXref
id: H2QIE3
db: uniprot

uniprot I2CU78 27
type: UnificationXref
id: I2CU78
db: uniprot

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot O88643 323
organism: Mus musculus

uniprot O77627 504
type: UnificationXref
id: O77627
db: uniprot

Y505 Lck s17 a19 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y505
feature location: Y505 Lck s17 a19 rs2 Y505
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y505
comment: MODIFICATION_RESIDUE_ANGLE=3.15

Y TCR zeta s63 sa64 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y TCR zeta s63 sa64 rs4 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=5.77761058581875

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q07890 184
xref: PTHR23113:SF150
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6W3Y0 315
xref: PTHR48015:SF30
organism: Xenopus tropicalis

Calmodulin s86 sa87 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Calmodulin
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__fos-_jun-RIGHT__Complex__jun_fos_-_r53
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 886
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 887
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 888
left: jun
left: fos
interaction type: HETERODIMER_ASSOCIATION
right: Complex (jun/fos)

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F7B5L8 514
organism: Ornithorhynchus anatinus

y CD3 delta s50 sa51 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 delta s50 sa51 rs2 y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=2.412924694611101

cdc42 s12 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cdc42
stoichiometric coefficient: 1.0

uniprot P10747 252
type: UnificationXref
id: P10747
db: uniprot

PARTICIPANT STOICHIOMETRY r97 821
type: Stoichiometry
physical entity: CD45
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r97 820
type: Stoichiometry
physical entity: CD45
stoichiometric coefficient: 2.0

Phosphoinositide-3-kinase regulatory subunit 3
type: ProteinReference
xref: uniprot A0A2I3RH39 351
xref: PTHR10155:SF2
organism: Pan troglodytes

Lymphocyte cytosolic protein 2
type: ProteinReference
xref: PTHR14098:SF1
xref: uniprot Q60787 346
organism: Mus musculus

uniprot Q60631 89
type: UnificationXref
id: Q60631
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r105
control type: ACTIVATION
controller: IP3

PLC gamma s455 a725 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Akt s34 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

uniprot H2RGZ2 56
type: UnificationXref
id: H2RGZ2
db: uniprot

PARTICIPANT STOICHIOMETRY r82 902
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 901
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 23

PARTICIPANT STOICHIOMETRY r82 900
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot F6WX28 195
type: UnificationXref
id: F6WX28
db: uniprot

T ERK s248 a403 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T ERK s248 a403 rs1 T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7GJZ7 92
type: UnificationXref
id: F7GJZ7
db: uniprot

rac s510 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: rac
stoichiometric coefficient: 1.0

T-cell-specific surface glycoprotein CD28
type: ProteinReference
xref: PTHR11494:SF7
xref: uniprot P10747 252
organism: Homo sapiens

y CD3 delta s50 sa51 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 delta s50 sa51 rs1 y
comment: MODIFICATION_RESIDUE_ANGLE=3.8870116001312134
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y

uniprot P07766 79
type: UnificationXref
id: P07766
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P04627 220
xref: PTHR44329:SF55
organism: Mus musculus

Gads
type: Protein
entity reference: Gads
feature: COMPLEX PARTICIPANT BINDING FEATURE s95 sa96 619
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MLL9 523
xref: PTHR25466:SF2
organism: Bos taurus

Y ERK s248 a403 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ERK s248 a403 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=-0.0

uniprot H2Q4V9 78
type: UnificationXref
id: H2Q4V9
db: uniprot

uniprot F6VQP7 466
type: UnificationXref
id: F6VQP7
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 207
xref: uniprot P05625 221
xref: PTHR44329:SF22
organism: Gallus gallus

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05627 506
organism: Mus musculus

uniprot Q9R0C8 35
type: UnificationXref
id: Q9R0C8
db: uniprot

uniprot E2REH3 311
type: UnificationXref
id: E2REH3
db: uniprot

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2QLB4 67
type: UnificationXref
id: H2QLB4
db: uniprot

PARTICIPANT STOICHIOMETRY r95 829
type: Stoichiometry
physical entity: MHC -antigen
stoichiometric coefficient: 1.0

uniprot F7GEK1 484
type: UnificationXref
id: F7GEK1
db: uniprot

uniprot P48736 404
type: UnificationXref
id: P48736
db: uniprot

uniprot A0A452J7W4 250
type: UnificationXref
id: A0A452J7W4
db: uniprot

uniprot P62157 142
type: UnificationXref
id: P62157
db: uniprot

HOMODIMER ID 84STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 eta
stoichiometric coefficient: 2.0

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r95 830
type: Stoichiometry
physical entity: Complex (CD3 gamma/TCR alpha/ TCR Beta/CD3 delta/ CD3 eta/TCR zeta)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r95 831
type: Stoichiometry
physical entity: Complex (TCR Beta/MHC-antigen/ CD3 gamma/TCR alpha/ CD3 eta/CD3 delta/ TCR zeta)
stoichiometric coefficient: 1.0

PANTHER Pathway P00053 1
type: UnificationXref
id: P00053
db: PANTHER Pathway

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O35904 391
organism: Mus musculus

rac
type: Protein
entity reference: rac
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa21 679
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

LAT
type: Protein
entity reference: LAT
feature: Y132 LAT s406 a275 rs2
feature: Y191 LAT s406 a275 rs4
feature: Y226 LAT s406 a275 rs5
feature: Y171 LAT s406 a275 rs3
feature: Y110 LAT s406 a275 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CD3 gamma s69 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 gamma
stoichiometric coefficient: 1.0

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot F7HC75 303
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Lck-RIGHT__Lck-_Pi-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 769
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 768
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 770
left: Lck
interaction type: STATE_TRANSITION
right: Lck
right: Pi

LAT
type: Protein
entity reference: LAT
feature: Y171 LAT s76 sa74 rs3
feature: Y132 LAT s76 sa74 rs2
feature: Y110 LAT s76 sa74 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s76 sa74 589
feature: Y226 LAT s76 sa74 rs5
feature: Y191 LAT s76 sa74 rs4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y SLP 76 s68 sa100 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s68 sa100 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=Y

LAT
type: Protein
entity reference: LAT
feature: Y226 LAT s93 sa94 rs5
feature: Y110 LAT s93 sa94 rs1
feature: Y191 LAT s93 sa94 rs4
feature: Y132 LAT s93 sa94 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s93 sa94 615
feature: Y171 LAT s93 sa94 rs3
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SLP-76
type: Protein
entity reference: SLP-76
feature: Y SLP 76 s2 sa2 rs1
feature: Y SLP 76 s2 sa2 rs3
feature: Y SLP 76 s2 sa2 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 567
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P20651 288
type: UnificationXref
id: P20651
db: uniprot

ncbitaxon 9598 11
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot P31042 254
type: UnificationXref
id: P31042
db: uniprot

T-cell surface glycoprotein CD3 epsilon chain
type: ProteinReference
xref: uniprot P27597 81
xref: PTHR10570:SF9
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A0A2I3RSP9 276
xref: PTHR45673:SF5
organism: Pan troglodytes

Puccinia graminis
type: BioSource
xref: ncbitaxon 418459 119

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot D4A3T0 168
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r115 783
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r115 782
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q99M51 273
type: UnificationXref
id: Q99M51
db: uniprot

TCR Beta
type: Protein
entity reference: TCR Beta
feature: COMPLEX PARTICIPANT BINDING FEATURE s52 sa53 645
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y SLP 76 s68 sa100 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s68 sa100 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.900215879598692

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot E2RIF9 363
xref: PTHR10048:SF7
organism: Canis lupus familiaris

uniprot P12841 200
type: UnificationXref
id: P12841
db: uniprot

CD3 gamma s39 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 gamma
stoichiometric coefficient: 1.0

HOMODIMER ID 86STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 eta
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1C600 37
xref: PTHR10035:SF2
organism: Gallus gallus

uniprot F7F3S0 378
type: UnificationXref
id: F7F3S0
db: uniprot

DAG s22 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

uniprot E2RFF7 91
type: UnificationXref
id: E2RFF7
db: uniprot

NF-kappa B
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa30 701
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y SLP 76 s68 sa100 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s68 sa100 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=2.3201360379273255

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot E2REH3 311
organism: Canis lupus familiaris

Gads s95 sa96 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gads
stoichiometric coefficient: 1.0

CD3D isoform 1
type: ProteinReference
xref: PTHR10570:SF5
xref: uniprot H2Q4W0 437
organism: Pan troglodytes

T-cell surface glycoprotein CD3 delta chain
type: ProteinReference
xref: PTHR10570:SF5
xref: uniprot P19377 440
organism: Rattus norvegicus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 105

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EP57 377
xref: PTHR10155:SF1
organism: Macaca mulatta

uniprot P23727 397
type: UnificationXref
id: P23727
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 131

PARTICIPANT STOICHIOMETRY r39 778
type: Stoichiometry
physical entity: Complex (cdc42/GTP/ WASP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r39 776
type: Stoichiometry
physical entity: Complex (cdc42/GTP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r39 777
type: Stoichiometry
physical entity: WASP
stoichiometric coefficient: 1.0

LAT s104 sa108 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LAT
stoichiometric coefficient: 1.0

Y SLP 76 s2 sa2 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s2 sa2 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=Y

Y110 LAT s97 sa101 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y110
feature location: Y110 LAT s97 sa101 rs1 Y110
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y110
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

uniprot Q95KV1 461
type: UnificationXref
id: Q95KV1
db: uniprot

TCR zeta
type: Protein
entity reference: TCR zeta
feature: Y TCR zeta s58 sa59 rs4
feature: Y TCR zeta s58 sa59 rs6
feature: Y TCR zeta s58 sa59 rs1
feature: Y TCR zeta s58 sa59 rs5
feature: Y TCR zeta s58 sa59 rs3
feature: Y TCR zeta s58 sa59 rs2

CD3E isoform 2
type: ProteinReference
xref: uniprot H2Q4V9 78
xref: PTHR10570:SF9
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q8BTI9 409
organism: Mus musculus

ncbitaxon 9258 175
type: UnificationXref
id: 9258
db: ncbitaxon

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 207
evidence: Evidence 209
evidence: Evidence 206
evidence: Evidence 208
xref: uniprot E2REI6 214
xref: PTHR44329:SF22
organism: Canis lupus familiaris

uniprot Q99N57 230
type: UnificationXref
id: Q99N57
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q07889 183
xref: PTHR23113:SF168
organism: Homo sapiens

Y226 LAT s4 a4 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y226
feature location: Y226 LAT s4 a4 rs5 Y226
comment: MODIFICATION_RESIDUE_ANGLE=3.5851730116547973
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y226

CD3 delta s61 sa62 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 delta
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6SEH5 284
xref: PTHR45673:SF7
organism: Macaca mulatta

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: uniprot O08908 390
xref: PTHR10155:SF1
organism: Mus musculus

nck s103 sa107 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: nck
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2R2N2 60
xref: PTHR24055:SF203
organism: Canis lupus familiaris

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot F7GD33 266
organism: Monodelphis domestica

uniprot C3ZEV9 113
type: UnificationXref
id: C3ZEV9
db: uniprot

Complex (CD3 gamma/TCR alpha/ TCR Beta/CD3 delta/ CD3 eta/TCR zeta)
type: Complex
component stoichiometry: CD3 delta s42 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: CD3 gamma s39 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCR alpha s40 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 83STOICHIOMETRY ID COMPLEX
component stoichiometry: TCR Beta s41 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
component: TCR Beta
component: CD3 delta
component: CD3 gamma
component: TCR alpha
component: TCR zeta
component: CD3 eta
feature: COMPLEX BINDING FEATURE s362 a601 628
feature: COMPLEX BINDING FEATURE s362 a601 622
feature: COMPLEX BINDING FEATURE s362 a601 624
feature: COMPLEX BINDING FEATURE s362 a601 632
feature: COMPLEX BINDING FEATURE s362 a601 630
feature: COMPLEX BINDING FEATURE s362 a601 626
cellular location: cytosol

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot Q63789 406
xref: PTHR10155:SF2
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: uniprot Q63788 405
xref: PTHR10155:SF1
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P32871 400
organism: Bos taurus

Linker for activation of T-cells family member 1
type: ProteinReference
xref: uniprot O54957 434
xref: PTHR15586:SF0
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1M0G8 308
xref: PTHR48015:SF22
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LSY0 307
xref: PTHR48015:SF30
organism: Bos taurus

NFKB inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot E2RML9 415
organism: Canis lupus familiaris

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

IKK
type: ProteinReference
xref: P01330
standard name: Inhibitor of kappa-B kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: IKK Synonym: Inhibitor of NF-kappa B kinase Accession: P01330
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.IKK
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta
member entity reference: Conserved helix-loop-helix ubiquitous kinase
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha
member entity reference: Uncharacterized protein
member entity reference: Inhibitor of nuclear factor kappa B kinase subunit beta

uniprot H2R0G7 516
type: UnificationXref
id: H2R0G7
db: uniprot

Calmodulin 1
type: ProteinReference
xref: uniprot E2REK6 117
xref: PTHR23050:SF381
organism: Canis lupus familiaris

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot E1BE66 360
xref: PTHR10048:SF35
organism: Bos taurus

MODULATION
type: Control
xref: MODULATION
controlled: Actin polymerization
controller: Complex (rac/GTP/ Pak)

Y132 LAT s93 sa94 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y132
feature location: Y132 LAT s93 sa94 rs2 Y132
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3298847729394225
comment: MODIFICATION_RESIDUE_NAME=Y132

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q60823 492
organism: Mus musculus

B7 s38 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: B7
stoichiometric coefficient: 1.0

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P11881 468
xref: PTHR13715:SF52
organism: Mus musculus

uniprot P05627 506
type: UnificationXref
id: P05627
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 114

Y394 Lck s479 a3 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y394
feature location: Y394 Lck s479 a3 rs1 Y394
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y394
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.02

Gads
type: Protein
entity reference: Gads
feature: COMPLEX PARTICIPANT BINDING FEATURE s99 sa103 579
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YCI3 176
xref: PTHR23113:SF150
organism: Monodelphis domestica

Predicted protein
type: ProteinReference
xref: uniprot A9SHH7 108
organism: Physcomitrella patens

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P12841 200
xref: PTHR23351:SF4
organism: Rattus norvegicus

uniprot F7GAP5 381
type: UnificationXref
id: F7GAP5
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 517
xref: PTHR24055:SF222
organism: Homo sapiens

uniprot P01112 160
type: UnificationXref
id: P01112
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P45984 518
organism: Homo sapiens

Akt
type: ProteinReference
xref: P01332
standard name: protein kinase B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Akt Synonym: PKB,Protein Kinase B Accession: P01332
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Akt
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase

uniprot F1Q118 172
type: UnificationXref
id: F1Q118
db: uniprot

PARTICIPANT STOICHIOMETRY re61 883
type: Stoichiometry
physical entity: MEKK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re61 882
type: Stoichiometry
physical entity: MEKK
stoichiometric coefficient: 1.0

Complex (LAT/PLC-gamma/ Gads/SLP-76)
type: Complex
component stoichiometry: PLC gamma s94 sa95 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gads s95 sa96 STOICHIOMETRY ID COMPLEX
component stoichiometry: SLP 76 s96 sa97 STOICHIOMETRY ID COMPLEX
component stoichiometry: LAT s93 sa94 STOICHIOMETRY ID COMPLEX
component: Gads
component: SLP-76
component: PLC-gamma
component: LAT
feature: COMPLEX BINDING FEATURE s464 a720 618
feature: COMPLEX BINDING FEATURE s464 a720 620
feature: COMPLEX BINDING FEATURE s464 a720 614
feature: COMPLEX BINDING FEATURE s464 a720 616
cellular location: cytosol

uniprot A0A2I3TLP8 13
type: UnificationXref
id: A0A2I3TLP8
db: uniprot

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

Raf s111 sa86 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

Raf
type: Protein
entity reference: Raf
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa82 689
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2QW34 455
type: UnificationXref
id: H2QW34
db: uniprot

uniprot F1MYJ4 476
type: UnificationXref
id: F1MYJ4
db: uniprot

Complex (LAT/PLC-gamma/ Gads/SLP-76)
type: Complex
component stoichiometry: SLP 76 s92 sa93 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gads s91 sa92 STOICHIOMETRY ID COMPLEX
component stoichiometry: PLC gamma s90 sa91 STOICHIOMETRY ID COMPLEX
component stoichiometry: LAT s89 sa90 STOICHIOMETRY ID COMPLEX
component: PLC-gamma
component: SLP-76
component: Gads
component: LAT
feature: COMPLEX BINDING FEATURE s461 a717 610
feature: COMPLEX BINDING FEATURE s461 a717 608
feature: COMPLEX BINDING FEATURE s461 a717 612
feature: COMPLEX BINDING FEATURE s461 a717 606
cellular location: cytosol

WASP
type: Protein
entity reference: WASP
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa20 573
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P14056 225
xref: PTHR44329:SF55
organism: Rattus norvegicus

Guanine nucleotide exchange factor VAV2 isoform 1
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot I2CU78 27
organism: Macaca mulatta

STATE_TRANSITION_LEFT__ATP-_PIP2-RIGHT__ADP-_PIP3-_r82
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 902
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 899
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 900
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 901
left: ATP
left: PIP2
interaction type: STATE_TRANSITION
right: ADP
right: PIP3

rac
type: Protein
entity reference: rac
feature: COMPLEX PARTICIPANT BINDING FEATURE s510 sa10 713
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 124

uniprot Q28071 256
type: UnificationXref
id: Q28071
db: uniprot

PARTICIPANT STOICHIOMETRY r113 799
type: Stoichiometry
physical entity: Complex (LAT/Gads/ SLP-76)
stoichiometric coefficient: 1.0

CD3 gamma s60 sa61 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r113 798
type: Stoichiometry
physical entity: Pak
stoichiometric coefficient: 1.0

SOS
type: ProteinReference
xref: P01307
standard name: Son of sevenless
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.SOS
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: Son of sevenless homolog 2
member entity reference: Uncharacterized protein
member entity reference: Son of sevenless homolog 1

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF39
xref: uniprot Q3ZCM0 204
organism: Bos taurus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXS9 90
xref: PTHR24418:SF407
organism: Gallus gallus

uniprot H9ZD75 502
type: UnificationXref
id: H9ZD75
db: uniprot

y CD3 eta s49 sa50 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 eta s49 sa50 rs2 y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=2.412924694611101

uniprot P33681 530
type: UnificationXref
id: P33681
db: uniprot

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot Q61411 166
organism: Mus musculus

IKK
type: Protein
entity reference: IKK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P08556 161
organism: Mus musculus

uniprot A0A3Q1LQK4 356
type: UnificationXref
id: A0A3Q1LQK4
db: uniprot

Lymphocyte cytosolic protein 2
type: ProteinReference
xref: PTHR14098:SF1
xref: uniprot Q13094 345
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F6QE96 479
organism: Macaca mulatta

TRANSCRIPTION
type: InteractionVocabulary

uniprot A0A2I3RJ26 275
type: UnificationXref
id: A0A2I3RJ26
db: uniprot

Y SLP 76 s100 sa104 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s100 sa104 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=2.3201360379273255

CD3 eta s62 sa63 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 eta
stoichiometric coefficient: 2.0

Phosphoinositide-3-kinase regulatory subunit 2
type: ProteinReference
xref: uniprot H2QFS6 385
xref: PTHR10155:SF1
organism: Pan troglodytes

uniprot F7CU42 318
type: UnificationXref
id: F7CU42
db: uniprot

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa29 673
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F1PRG4 477
organism: Canis lupus familiaris

PTHR10048:SF7
type: RelationshipXref
id: PTHR10048:SF7
db: PANTHER Family
relationship type: By Homology

Y132 LAT s76 sa74 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y132
feature location: Y132 LAT s76 sa74 rs2 Y132
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3298847729394225
comment: MODIFICATION_RESIDUE_NAME=Y132

I kappa B s30 sa31 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6QE96 479
type: UnificationXref
id: F6QE96
db: uniprot

IKK
type: Protein
entity reference: IKK
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r100 879
type: Stoichiometry
physical entity: Complex (LAT/SLP-76/ Grb2/SOS/ Gads/PLC-gamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r100 878
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r100 875
type: Stoichiometry
physical entity: Complex (SOS/Grb2)
stoichiometric coefficient: 1.0

CD86 molecule
type: ProteinReference
xref: PTHR25466:SF2
xref: uniprot O35531 529
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r100 877
type: Stoichiometry
physical entity: Complex (Gads/SLP-76)
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot E2RJA0 312
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot H2QKD0 336
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r100 876
type: Stoichiometry
physical entity: LAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 899
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r111
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 818
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 819
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 817
left: PIP2
interaction type: DISSOCIATION
right: DAG
right: IP3

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P10398 222
xref: PTHR44329:SF55
organism: Homo sapiens

uniprot P11942 298
type: UnificationXref
id: P11942
db: uniprot

GRB2-related adapter protein 2
type: ProteinReference
xref: PTHR46037:SF3
xref: uniprot O75791 443
organism: Homo sapiens

WASP
type: Protein
entity reference: WASP
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gads s67 sa99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gads
stoichiometric coefficient: 1.0

Receptor-type tyrosine-protein phosphatase C
type: ProteinReference
xref: uniprot P08575 447
xref: PTHR19134:SF284
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r107 842
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Ca++
type: SmallMolecule
comment: SPECIES_TYPE=ION

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot O88763 395
xref: PTHR10048:SF7
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r107 843
type: Stoichiometry
physical entity: Complex (LAT/PLC-gamma/ Gads/SLP-76)
stoichiometric coefficient: 1.0

Y SLP 76 s100 sa104 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s100 sa104 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=Y

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 695
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

vav
type: ProteinReference
xref: P01295
standard name: Guanine nucleotide exchange factor VAV
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: vav Synonym: Synonym not specified Accession: P01295
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.vav
member entity reference: Uncharacterized protein
member entity reference: Vav guanine nucleotide exchange factor 2
member entity reference: Proto-oncogene vav
member entity reference: Guanine nucleotide exchange factor VAV2
member entity reference: Guanine nucleotide exchange factor VAV2 isoform 1
member entity reference: Guanine nucleotide exchange factor VAV3
member entity reference: Vav guanine nucleotide exchange factor 3
member entity reference: VAV1 isoform 2
member entity reference: VAV2 isoform 2
member entity reference: Vav guanine nucleotide exchange factor 1

CD3 antigen, zeta polypeptide, isoform CRA_b
type: ProteinReference
xref: uniprot Q4V7G0 43
xref: PTHR10035:SF2
organism: Rattus norvegicus

ATP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Calmodulin-1
type: ProteinReference
xref: PTHR23050:SF383
xref: uniprot P0DP29 136
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot K7CDC2 486
organism: Pan troglodytes

Pak
type: ProteinReference
xref: P01319
standard name: p21-activated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Pak Synonym: p21-activated kinase Accession: P01319
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Pak
member entity reference: Serine/threonine-protein kinase PAK 3
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase PAK 2
member entity reference: Serine/threonine-protein kinase PAK 1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Complex__LAT_PLC_gamma__Gads_SLP_76_-RIGHT__ADP-_Complex__LAT_PLC_gamma__Gads_SLP_76_-_r107
controller: ZAP-70

uniprot Q9Z1L0 413
type: UnificationXref
id: Q9Z1L0
db: uniprot

PARTICIPANT STOICHIOMETRY r92 836
type: Stoichiometry
physical entity: NF-kappa B
stoichiometric coefficient: 1.0

Complex (CD3 gamma/TCR Beta/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)
type: Complex
component stoichiometry: TCR alpha s75 sa73 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 48STOICHIOMETRY ID COMPLEX
component stoichiometry: CD3 gamma s69 sa67 STOICHIOMETRY ID COMPLEX
component stoichiometry: CD3 delta s71 sa69 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 87STOICHIOMETRY ID COMPLEX
component stoichiometry: TCR Beta s70 sa68 STOICHIOMETRY ID COMPLEX
component stoichiometry: ZAP 70 s507 sa72 STOICHIOMETRY ID COMPLEX
component: CD3 eta
component: TCR zeta
component: CD3 gamma
component: TCR alpha
component: TCR Beta
component: CD3 delta
component: ZAP-70
feature: COMPLEX BINDING FEATURE s437 a667 550
feature: COMPLEX BINDING FEATURE s437 a667 556
feature: COMPLEX BINDING FEATURE s437 a667 554
feature: COMPLEX BINDING FEATURE s437 a667 546
feature: COMPLEX BINDING FEATURE s437 a667 558
feature: COMPLEX BINDING FEATURE s437 a667 552
feature: COMPLEX BINDING FEATURE s437 a667 548
cellular location: cytosol

y CD3 eta s49 sa50 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 eta s49 sa50 rs1 y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=3.91785828020355

PARTICIPANT STOICHIOMETRY r92 837
type: Stoichiometry
physical entity: NF-kappa B
stoichiometric coefficient: 1.0

Calmodulin-3
type: ProteinReference
xref: PTHR23050:SF381
xref: uniprot P0DP28 135
organism: Mus musculus

uniprot P14056 225
type: UnificationXref
id: P14056
db: uniprot

Calmodulin-1
type: ProteinReference
xref: PTHR23050:SF427
xref: uniprot P0DP23 134
organism: Homo sapiens

AGAP010957-PA (Fragment)
type: ProteinReference
xref: uniprot Q7QGY7 149
xref: PTHR23050:SF245
organism: Anopheles gambiae

PTHR19134:SF284
type: RelationshipXref
id: PTHR19134:SF284
db: PANTHER Family
relationship type: By Homology

Y SLP 76 s100 sa104 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s100 sa104 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.900215879598692

Jnk s250 a405 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

HOMODIMER ID 48STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR zeta
stoichiometric coefficient: 2.0

WASP
type: ProteinReference
xref: P01334
comment: ENTITY_REFERENCE_NOTES= Long Name: WASP Synonym: Wiscott-Aldrich Syndrome Protein Accession: P01334
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.WASP
member entity reference: Wiskott-Aldrich syndrome protein

PARTICIPANT STOICHIOMETRY r67 810
type: Stoichiometry
physical entity: I kappa B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r107 841
type: Stoichiometry
physical entity: Complex (LAT/PLC-gamma/ Gads/SLP-76)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r107 840
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

ZAP-70
type: ProteinReference
xref: P01308
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.ZAP-70
comment: ENTITY_REFERENCE_NOTES= Long Name: ZAP-70 Synonym: Zeta-associated protein of 70 kD Accession: P01308
member entity reference: Tyrosine-protein kinase ZAP-70
member entity reference: Tyrosine-protein kinase

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot A0A3Q3ACS4 357
organism: Gallus gallus

CD3 gamma
type: Protein
entity reference: CD3 gamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa40 623
feature: y CD3 gamma s39 sa40 rs1
feature: y CD3 gamma s39 sa40 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P60953 499
type: UnificationXref
id: P60953
db: uniprot

Y SLP 76 s106 sa110 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s106 sa110 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.900215879598692

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s110 sa85 637
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2QS62 515
type: UnificationXref
id: H2QS62
db: uniprot

CRAC
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR25466:SF4
xref: uniprot F7HRG1 526
organism: Macaca mulatta

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1N7C3 170
xref: PTHR23113:SF168
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63085 72
xref: PTHR24055:SF203
organism: Mus musculus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63086 73
xref: PTHR24055:SF203
organism: Rattus norvegicus

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot P41240 96
xref: PTHR24418:SF407
organism: Homo sapiens

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot P41241 97
xref: PTHR24418:SF407
organism: Mus musculus

MODULATION
type: Control
xref: MODULATION
controlled: T cell proliferation
controller: TCR-responsive genes

CD3 gamma s55 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 gamma
stoichiometric coefficient: 1.0

Y SLP 76 s106 sa110 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s106 sa110 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot A8WPJ8 104
type: UnificationXref
id: A8WPJ8
db: uniprot

Complex (rac/GDP)
type: Complex
component stoichiometry: GDP s511 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: rac s112 sa12 STOICHIOMETRY ID COMPLEX
component: GDP
component: rac
feature: COMPLEX BINDING FEATURE s266 a435 560
feature: COMPLEX BINDING FEATURE s266 a435 562
cellular location: cytosol

IDA
type: EvidenceCodeVocabulary

TCR Beta s70 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR Beta
stoichiometric coefficient: 1.0

uniprot F6SV58 122
type: UnificationXref
id: F6SV58
db: uniprot

TCR zeta
type: Protein
entity reference: TCR zeta
feature: Y TCR zeta s73 sa71 rs6
feature: Y TCR zeta s73 sa71 rs2
feature: Y TCR zeta s73 sa71 rs4
feature: Y TCR zeta s73 sa71 rs1
feature: Y TCR zeta s73 sa71 rs3
feature: Y TCR zeta s73 sa71 rs5

Uncharacterized protein
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot A0A1D5R1G4 414
organism: Macaca mulatta

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Jnk-RIGHT__Jnk-_r54
controller: MEKK

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

Rac family small GTPase 1
type: ProteinReference
xref: uniprot Q6GL60 429
xref: PTHR24072:SF105
organism: Xenopus tropicalis

uniprot O88351 458
type: UnificationXref
id: O88351
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 207
evidence: Evidence 209
evidence: Evidence 206
evidence: Evidence 208
xref: uniprot F7BRK5 216
xref: PTHR44329:SF22
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q02750 243
organism: Homo sapiens

uniprot A0A2I3SR38 300
type: UnificationXref
id: A0A2I3SR38
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r115
controller: Complex (CD28/B7)

uniprot Q9GKP3 257
type: UnificationXref
id: Q9GKP3
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q62245 185
xref: PTHR23113:SF168
organism: Mus musculus

uniprot W4XNQ0 151
type: UnificationXref
id: W4XNQ0
db: uniprot

uniprot F6TD14 370
type: UnificationXref
id: F6TD14
db: uniprot

uniprot A0A2I3T9Y4 471
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

Tyrosine-protein kinase Lck
type: ProteinReference
xref: PTHR24418:SF39
xref: uniprot P06239 201
organism: Homo sapiens

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot E2RJ59 281
xref: PTHR45673:SF7
organism: Canis lupus familiaris

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot Q9QY78 462
organism: Rattus norvegicus

MEK
type: Protein
entity reference: MEK
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa83 691
feature: MEK s85 sa83 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y SLP 76 s106 sa110 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s106 sa110 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=2.3201360379273255

uniprot Q08209 295
type: UnificationXref
id: Q08209
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__MEKK-RIGHT__MEKK-_r85
controller: Complex (PIP2/Akt)

CD3 eta
type: Protein
entity reference: CD3 eta
feature: y CD3 eta s57 sa58 rs1
feature: y CD3 eta s57 sa58 rs2

PI3K
type: ProteinReference
xref: P01322
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: PI3K Synonym: Phosphatidyl Inositol (3,4,5) kinase Accession: P01322
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.PI3K
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: PIK3CG isoform 1
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit beta
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha
member entity reference: Phosphoinositide-3-kinase regulatory subunit 2
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit gamma
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphoinositide-3-kinase regulatory subunit 1
member entity reference: Phosphoinositide-3-kinase regulatory subunit 3
member entity reference: PIK3R1 isoform 1
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

uniprot P63329 294
type: UnificationXref
id: P63329
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 121

CD3 delta s56 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 delta
stoichiometric coefficient: 1.0

Proto-oncogene tyrosine-protein kinase LCK
type: ProteinReference
xref: PTHR24418:SF39
xref: uniprot P06240 202
organism: Mus musculus

uniprot Q60992 34
type: UnificationXref
id: Q60992
db: uniprot

uniprot A5A6H0 192
type: UnificationXref
id: A5A6H0
db: uniprot

Calmodulin
type: ProteinReference
xref: uniprot P02599 132
organism: Dictyostelium discoideum

Raf
type: Protein
entity reference: Raf
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q05144 425
type: UnificationXref
id: Q05144
db: uniprot

uniprot P16298 287
type: UnificationXref
id: P16298
db: uniprot

GTPase HRas isoform 1
type: ProteinReference
xref: uniprot F7F5K9 157
xref: PTHR24070:SF385
organism: Macaca mulatta

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: uniprot F1LWB1 20
xref: PTHR45818:SF1
organism: Rattus norvegicus

uniprot K7CDC2 486
type: UnificationXref
id: K7CDC2
db: uniprot

Tyrosine-protein kinase CSK
type: ProteinReference
xref: PTHR24418:SF407
xref: uniprot Q0VBZ0 98
organism: Bos taurus

uniprot P31041 253
type: UnificationXref
id: P31041
db: uniprot

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q63746 418
organism: Rattus norvegicus

MEK s247 a692 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A0G2K5T3 349
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

CD3 gamma
type: Protein
entity reference: CD3 gamma
feature: y CD3 gamma s55 sa56 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa56 651
feature: y CD3 gamma s55 sa56 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F1PS03 334
organism: Canis lupus familiaris

Cytoplasmic protein NCK1
type: ProteinReference
xref: uniprot P16333 271
xref: PTHR19969:SF16
organism: Homo sapiens

uniprot F7BAS2 317
type: UnificationXref
id: F7BAS2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A567 496
xref: PTHR24072:SF136
organism: Monodelphis domestica

uniprot E1C2T7 280
type: UnificationXref
id: E1C2T7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K344 348
organism: Rattus norvegicus

PIP3
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 7719 124
type: UnificationXref
id: 7719
db: ncbitaxon

TCR alpha s40 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR alpha
stoichiometric coefficient: 1.0

uniprot Q02750 243
type: UnificationXref
id: Q02750
db: uniprot

PTHR23050:SF385
type: RelationshipXref
id: PTHR23050:SF385
db: PANTHER Family
relationship type: By Homology

T-cell surface glycoprotein CD3 gamma chain
type: ProteinReference
xref: PTHR10570:SF8
xref: uniprot P09693 297
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r104 850
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r104 851
type: Stoichiometry
physical entity: Calmodulin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r104 852
type: Stoichiometry
physical entity: Complex (Calmodulin/Ca++/ Ca++)
stoichiometric coefficient: 1.0

PTHR23050:SF381
type: RelationshipXref
id: PTHR23050:SF381
db: PANTHER Family
relationship type: By Homology

PTHR23050:SF383
type: RelationshipXref
id: PTHR23050:SF383
db: PANTHER Family
relationship type: By Homology

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot P25963 417
organism: Homo sapiens

uniprot F7GD33 266
type: UnificationXref
id: F7GD33
db: uniprot

uniprot Q5ZIF0 246
type: UnificationXref
id: Q5ZIF0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3S5ZP81 524
xref: PTHR25466:SF4
organism: Bos taurus

PTHR23202:SF3
type: RelationshipXref
id: PTHR23202:SF3
db: PANTHER Family
relationship type: By Homology

cdc42
type: Protein
entity reference: cdc42
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa16 705
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r48 767
type: Stoichiometry
physical entity: Calcineurin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 766
type: Stoichiometry
physical entity: Calcineurin
stoichiometric coefficient: 1.0

Jnk s251 a407 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1Q3M8 367
xref: PTHR10048:SF107
organism: Canis lupus familiaris

SLP-76
type: Protein
entity reference: SLP-76
feature: Y SLP 76 s96 sa97 rs3
feature: Y SLP 76 s96 sa97 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 sa97 621
feature: Y SLP 76 s96 sa97 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GDP s511 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q5ZIF0 246
organism: Gallus gallus

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot P35465 324
xref: PTHR48015:SF20
organism: Rattus norvegicus

uniprot P15498 28
type: UnificationXref
id: P15498
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot H9FVU5 387
organism: Macaca mulatta

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36507 241
organism: Homo sapiens

B7
type: Protein
entity reference: B7
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa39 669
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36506 240
organism: Rattus norvegicus

TCR alpha s54 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR alpha
stoichiometric coefficient: 1.0

uniprot F7EH19 63
type: UnificationXref
id: F7EH19
db: uniprot

uniprot F1PS03 334
type: UnificationXref
id: F1PS03
db: uniprot

CD3 delta
type: Protein
entity reference: CD3 delta
feature: y CD3 delta s56 sa57 rs2
feature: y CD3 delta s56 sa57 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa57 653
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CRAC
type: Protein
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

PTPRC isoform 2
type: ProteinReference
xref: PTHR19134:SF284
xref: uniprot H2Q0U9 445
organism: Pan troglodytes

Complex (Ras/GTP/ Raf)
type: Complex
component stoichiometry: Ras s109 sa84 STOICHIOMETRY ID COMPLEX
component stoichiometry: Raf s111 sa86 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s110 sa85 STOICHIOMETRY ID COMPLEX
component: Ras
component: Raf
component: GTP
feature: COMPLEX BINDING FEATURE s490 a693 638
feature: COMPLEX BINDING FEATURE s490 a693 634
feature: COMPLEX BINDING FEATURE s490 a693 636
cellular location: cytosol

ncbitaxon 6239 131
type: UnificationXref
id: 6239
db: ncbitaxon

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

uniprot F7FAI7 188
type: UnificationXref
id: F7FAI7
db: uniprot

uniprot H2R2L9 39
type: UnificationXref
id: H2R2L9
db: uniprot

Complex (Ras/GDP )
type: Complex
component stoichiometry: GDP s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ras s3 sa3 STOICHIOMETRY ID COMPLEX
component: Ras
component: GDP
feature: COMPLEX BINDING FEATURE s242 a388 692
feature: COMPLEX BINDING FEATURE s242 a388 694
cellular location: cytosol

PTHR24418:SF369
type: RelationshipXref
id: PTHR24418:SF369
db: PANTHER Family
relationship type: By Homology

Putative calmodulin
type: ProteinReference
xref: uniprot Q4QHT2 145
organism: Leishmania major

SOS s79 sa77 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 358
organism: Rattus norvegicus

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot F6Y841 374
xref: PTHR10048:SF33
organism: Canis lupus familiaris

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

LAT s97 sa101 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LAT
stoichiometric coefficient: 1.0

CD3 delta
type: Protein
entity reference: CD3 delta
feature: y CD3 delta s71 sa69 rs2
feature: y CD3 delta s71 sa69 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s71 sa69 551
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TCR alpha
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa66 733
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P36507 241
type: UnificationXref
id: P36507
db: uniprot

uniprot P05412 505
type: UnificationXref
id: P05412
db: uniprot

Calmodulin-1
type: ProteinReference
xref: uniprot Q0JNS6 143
xref: PTHR23050:SF438
organism: Oryza sativa

Y226 LAT s93 sa94 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y226
feature location: Y226 LAT s93 sa94 rs5 Y226
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.5851730116547973
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y226

TCR Beta s45 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR Beta
stoichiometric coefficient: 1.0

TCR Beta
type: ProteinReference
xref: P01299
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.RECEPTOR.TCR_br_Beta
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Uncharacterized protein

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TD14 370
xref: PTHR10155:SF3
organism: Monodelphis domestica

uniprot O70173 394
type: UnificationXref
id: O70173
db: uniprot

Jnk
type: Protein
entity reference: Jnk
feature: Jnk s253 a406 rs1
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SLP-76
type: Protein
entity reference: SLP-76
feature: Y SLP 76 s77 sa75 rs2
feature: Y SLP 76 s77 sa75 rs3
feature: Y SLP 76 s77 sa75 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 sa75 591
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CD3 delta s50 sa51 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 delta
stoichiometric coefficient: 1.0

Lymphocyte cytosolic protein 2
type: ProteinReference
xref: PTHR14098:SF1
xref: uniprot Q920L0 347
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__Pak-_Complex__LAT_Gads__SLP_76_-_vav-_WASP-_nck-RIGHT__Complex__LAT_Pak__Gads_SLP_76__WASP_vav__nck_-_r113
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 801
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 802
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 798
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 799
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 803
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 800
left: Complex (LAT/Gads/ SLP-76)
left: WASP
left: nck
left: Pak
left: vav
interaction type: HETERODIMER_ASSOCIATION
right: Complex (LAT/Pak/ Gads/SLP-76/ WASP/vav/ nck)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6SW23 368
xref: PTHR10048:SF107
organism: Gallus gallus

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q91974 420
organism: Gallus gallus

DISSOCIATION_LEFT__Complex__Ras_GTP__Raf_MEK_-RIGHT__Complex__Ras_GTP__Raf_-_MEK-_r102
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 859
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 860
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 858
left: Complex (Ras/GTP/ Raf/MEK)
interaction type: DISSOCIATION
right: MEK
right: Complex (Ras/GTP/ Raf)

uniprot E2RIF9 363
type: UnificationXref
id: E2RIF9
db: uniprot

Jnk
type: ProteinReference
xref: P01336
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Jnk Synonym: Jun kinase,c-Jun N-terminal Kinase Accession: P01336
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Jnk
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase

uniprot F7GWI2 320
type: UnificationXref
id: F7GWI2
db: uniprot

uniprot F1MAI3 169
type: UnificationXref
id: F1MAI3
db: uniprot

TCR Beta
type: Protein
entity reference: TCR Beta
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa68 549
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gads
type: Protein
entity reference: Gads
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 565
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GTP s13 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

TCR zeta
type: Protein
entity reference: TCR zeta
feature: Y TCR zeta s44 sa45 rs4
feature: Y TCR zeta s44 sa45 rs3
feature: Y TCR zeta s44 sa45 rs6
feature: Y TCR zeta s44 sa45 rs1
feature: Y TCR zeta s44 sa45 rs5
feature: Y TCR zeta s44 sa45 rs2

Linker for activation of T-cells family member 1
type: ProteinReference
xref: PTHR15586:SF0
xref: uniprot O70601 435
organism: Rattus norvegicus

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60766 497
xref: PTHR24072:SF136
organism: Mus musculus

uniprot F6TAH0 335
type: UnificationXref
id: F6TAH0
db: uniprot

uniprot H2RA86 68
type: UnificationXref
id: H2RA86
db: uniprot

PARTICIPANT STOICHIOMETRY r7 759
type: Stoichiometry
physical entity: Lck
stoichiometric coefficient: 1.0

vav s102 sa106 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: vav
stoichiometric coefficient: 1.0

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F6URW3 174
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r7 757
type: Stoichiometry
physical entity: Lck
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 758
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 141

PARTICIPANT STOICHIOMETRY r7 756
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q5U1Y2 427
type: UnificationXref
id: Q5U1Y2
db: uniprot

Y110 LAT s406 a275 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y110
feature location: Y110 LAT s406 a275 rs1 Y110
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y110
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

uniprot A0A3S5ZPX3 233
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

LAT
type: Protein
entity reference: LAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s89 sa90 607
feature: Y191 LAT s89 sa90 rs4
feature: Y110 LAT s89 sa90 rs1
feature: Y171 LAT s89 sa90 rs3
feature: Y132 LAT s89 sa90 rs2
feature: Y226 LAT s89 sa90 rs5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gads s91 sa92 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gads
stoichiometric coefficient: 1.0

uniprot F7G800 319
type: UnificationXref
id: F7G800
db: uniprot

Gads s99 sa103 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gads
stoichiometric coefficient: 1.0

Y110 LAT s89 sa90 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y110
feature location: Y110 LAT s89 sa90 rs1 Y110
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y110
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

Receptor-type tyrosine-protein phosphatase C
type: ProteinReference
xref: PTHR19134:SF284
xref: uniprot P04157 446
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r28 847
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 508
xref: PTHR24055:SF162
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r28 846
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

ACTIVE 5
type: EntityFeature
comment: Active state

uniprot Q9Y243 494
type: UnificationXref
id: Q9Y243
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot P53349 52
organism: Mus musculus

uniprot A0A3Q3ACS4 357
type: UnificationXref
id: A0A3Q3ACS4
db: uniprot

By Homology
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q66JE6 248
organism: Xenopus tropicalis

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q6P023 75
xref: PTHR24055:SF203
organism: Danio rerio

PI3K
type: Protein
entity reference: PI3K
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A9V8J8 109
type: UnificationXref
id: A9V8J8
db: uniprot

Y110 LAT s93 sa94 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y110
feature location: Y110 LAT s93 sa94 rs1 Y110
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y110
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

CD3 delta
type: ProteinReference
xref: P01326
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.CD3_br_delta
comment: ENTITY_REFERENCE_NOTES=
member entity reference: T-cell surface glycoprotein CD3 delta chain
member entity reference: CD3D isoform 1
member entity reference: Uncharacterized protein

CD28
type: Complex
component stoichiometry: CD28 s320 a566 STOICHIOMETRY ID COMPLEX
component: CD28
cellular location: cytosol

PKC-theta
type: Protein
entity reference: PKC-theta
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa25 699
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CD28
type: Complex
component stoichiometry: CD28 s35 sa36 STOICHIOMETRY ID COMPLEX
component: CD28
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa36 663
cellular location: cytosol

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F1P630 510
organism: Canis lupus familiaris

uniprot A5D7T5 278
type: UnificationXref
id: A5D7T5
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Raf-_Complex__Ras_GTP_-RIGHT__Complex__Ras_GTP__Raf_-_r25
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 855
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 857
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 856
left: Complex (Ras/GTP)
left: Raf
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Ras/GTP/ Raf)

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Lck-RIGHT__ADP-_Lck-_r5
controller: Lck

jun
type: Protein
entity reference: jun
feature: jun s303 a501 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PLC gamma s90 sa91 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

PTHR24418:SF407
type: RelationshipXref
id: PTHR24418:SF407
db: PANTHER Family
relationship type: By Homology

uniprot F6Q932 283
type: UnificationXref
id: F6Q932
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 64

uniprot P26450 398
type: UnificationXref
id: P26450
db: uniprot

uniprot P62149 139
type: UnificationXref
id: P62149
db: uniprot

PARTICIPANT STOICHIOMETRY r99 805
type: Stoichiometry
physical entity: Complex (TCR Beta/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r99 804
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Proto-oncogene tyrosine-protein kinase LCK
type: ProteinReference
xref: PTHR24418:SF39
xref: uniprot Q01621 203
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r99 807
type: Stoichiometry
physical entity: Complex (CD3 gamma/TCR Beta/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r99 806
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q8CFN2 501
organism: Rattus norvegicus

Y132 LAT s66 sa98 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y132
feature location: Y132 LAT s66 sa98 rs2 Y132
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3298847729394225
comment: MODIFICATION_RESIDUE_NAME=Y132

TRIGGER
type: RelationshipTypeVocabulary

uniprot F7ALW1 264
type: UnificationXref
id: F7ALW1
db: uniprot

uniprot P41241 97
type: UnificationXref
id: P41241
db: uniprot

Y171 LAT s66 sa98 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y171
feature location: Y171 LAT s66 sa98 rs3 Y171
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7720410517750427
comment: MODIFICATION_RESIDUE_NAME=Y171

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2R0G7 516
xref: PTHR24055:SF222
organism: Pan troglodytes

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s83 sa81 687
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

eco ECO:0000245 50
type: UnificationXref
id: ECO:0000245
db: eco

uniprot E1C600 37
type: UnificationXref
id: E1C600
db: uniprot

Pak s98 sa102 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pak
stoichiometric coefficient: 1.0

CD3 delta
type: Protein
entity reference: CD3 delta
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa43 629
feature: y CD3 delta s42 sa43 rs2
feature: y CD3 delta s42 sa43 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gads s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gads
stoichiometric coefficient: 1.0

LAT
type: Protein
entity reference: LAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 sa101 575
feature: Y226 LAT s97 sa101 rs5
feature: Y171 LAT s97 sa101 rs3
feature: Y110 LAT s97 sa101 rs1
feature: Y191 LAT s97 sa101 rs4
feature: Y132 LAT s97 sa101 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: uniprot Q61036 328
xref: PTHR48015:SF30
organism: Mus musculus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot F6VAQ8 371
organism: Ornithorhynchus anatinus

vav s107 sa111 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: vav
stoichiometric coefficient: 1.0

uniprot Q7ZSZ9 432
type: UnificationXref
id: Q7ZSZ9
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A2I3T7A8 353
organism: Pan troglodytes

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E1BMG4 301
organism: Bos taurus

rac s18 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: rac
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P49186 519
organism: Rattus norvegicus

Y ERK s249 a404 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ERK s249 a404 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=-0.0

Y110 LAT s76 sa74 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y110
feature location: Y110 LAT s76 sa74 rs1 Y110
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y110
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

WASP s101 sa105 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WASP
stoichiometric coefficient: 1.0

ncbitaxon 3218 107
type: UnificationXref
id: 3218
db: ncbitaxon

uniprot A0A3Q2UBN4 296
type: UnificationXref
id: A0A3Q2UBN4
db: uniprot

TCR alpha
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa41 625
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot F7D094 265
organism: Macaca mulatta

uniprot P48454 291
type: UnificationXref
id: P48454
db: uniprot

uniprot P10398 222
type: UnificationXref
id: P10398
db: uniprot

uniprot B3RJX8 111
type: UnificationXref
id: B3RJX8
db: uniprot

Fos proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot E2QYK5 194
xref: PTHR23351:SF4
organism: Canis lupus familiaris

uniprot G2HHN0 267
type: UnificationXref
id: G2HHN0
db: uniprot

Ras s82 sa80 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

MEK s85 sa83 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

CD3 eta
type: Protein
entity reference: CD3 eta
feature: y CD3 eta s72 sa70 rs2
feature: y CD3 eta s72 sa70 rs1

PLC-gamma
type: Protein
entity reference: PLC-gamma
feature: PLC gamma s411 a305 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot E1C2T7 280
xref: PTHR45673:SF7
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__fos-_jun-RIGHT__Complex__jun_fos_-_r53
controller: ERK

uniprot H2QIH7 268
type: UnificationXref
id: H2QIH7
db: uniprot

Y SLP 76 s92 sa93 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s92 sa93 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=2.3201360379273255

Complex (cdc42/GTP)
type: Complex
component stoichiometry: GTP s13 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: cdc42 s12 sa16 STOICHIOMETRY ID COMPLEX
component: GTP
component: cdc42
feature: COMPLEX BINDING FEATURE s268 a437 706
feature: COMPLEX BINDING FEATURE s268 a437 704
feature: ACTIVE 5
cellular location: cytosol

HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR zeta
stoichiometric coefficient: 2.0

Y ZAP 70 s486 a373 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ZAP 70 s486 a373 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.496387147055939
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot P59220 137
type: UnificationXref
id: P59220
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31751 489
xref: PTHR24356:SF176
organism: Homo sapiens

uniprot P06239 201
type: UnificationXref
id: P06239
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31750 488
xref: PTHR24356:SF171
organism: Mus musculus

LAT
type: Protein
entity reference: LAT
feature: Y171 LAT s4 a4 rs3
feature: Y132 LAT s4 a4 rs2
feature: Y191 LAT s4 a4 rs4
feature: Y226 LAT s4 a4 rs5
feature: Y110 LAT s4 a4 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR10570:SF5
type: RelationshipXref
id: PTHR10570:SF5
db: PANTHER Family
relationship type: By Homology

B7
type: Protein
entity reference: B7
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa37 665
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6XP81 483
type: UnificationXref
id: F6XP81
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 17

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1N8W8 313
xref: PTHR48015:SF30
organism: Gallus gallus

SOS s27 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9WUA6 493
organism: Mus musculus

MEK s415 a400 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

NF-AT
type: Protein
feature: NF AT s293 a486 rs1
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3SIY1 352
type: UnificationXref
id: A0A2I3SIY1
db: uniprot

CD3 gamma s47 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 gamma
stoichiometric coefficient: 1.0

cdc42
type: Protein
entity reference: cdc42
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa18 569
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

T-cell surface glycoprotein CD3 gamma chain
type: ProteinReference
xref: PTHR10570:SF8
xref: uniprot P11942 298
organism: Mus musculus

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 229

uniprot P63086 73
type: UnificationXref
id: P63086
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31749 487
organism: Homo sapiens

PTHR10570:SF8
type: RelationshipXref
id: PTHR10570:SF8
db: PANTHER Family
relationship type: By Homology

WASP
type: Protein
entity reference: WASP
feature: COMPLEX PARTICIPANT BINDING FEATURE s101 sa105 583
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR10570:SF9
type: RelationshipXref
id: PTHR10570:SF9
db: PANTHER Family
relationship type: By Homology

uniprot F6QUW1 173
type: UnificationXref
id: F6QUW1
db: uniprot

uniprot F7BWW9 177
type: UnificationXref
id: F7BWW9
db: uniprot

PARTICIPANT STOICHIOMETRY r98 816
type: Stoichiometry
physical entity: Complex (TCR Beta/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P08487 337
xref: PTHR10336:SF173
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r98 815
type: Stoichiometry
physical entity: Complex (TCR Beta/MHC-antigen/ TCR alpha/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r98 814
type: Stoichiometry
physical entity: ZAP-70
stoichiometric coefficient: 1.0

uniprot H2R8U9 178
type: UnificationXref
id: H2R8U9
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7GJZ7 92
xref: PTHR24418:SF407
organism: Monodelphis domestica

uniprot C3ZEW2 116
type: UnificationXref
id: C3ZEW2
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot A0A2I3SR38 300
organism: Pan troglodytes

Pak s21 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pak
stoichiometric coefficient: 1.0

uniprot P01111 159
type: UnificationXref
id: P01111
db: uniprot

Y SLP 76 s92 sa93 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s92 sa93 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot P11881 468
type: UnificationXref
id: P11881
db: uniprot

Complex (LAT/Gads/ SLP-76)
type: Complex
component stoichiometry: SLP 76 s68 sa100 STOICHIOMETRY ID COMPLEX
component stoichiometry: LAT s66 sa98 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gads s67 sa99 STOICHIOMETRY ID COMPLEX
component: LAT
component: Gads
component: SLP-76
feature: COMPLEX BINDING FEATURE s419 a729 604
feature: COMPLEX BINDING FEATURE s419 a729 602
feature: COMPLEX BINDING FEATURE s419 a729 600
cellular location: cytosol

Calmodulin-2
type: ProteinReference
xref: uniprot Q6F332 147
xref: PTHR23050:SF385
organism: Oryza sativa

uniprot P21708 69
type: UnificationXref
id: P21708
db: uniprot

Ca++
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

uniprot P48452 289
type: UnificationXref
id: P48452
db: uniprot

T-cell surface glycoprotein CD3 epsilon chain
type: ProteinReference
xref: uniprot P07766 79
xref: PTHR10570:SF9
organism: Homo sapiens

uniprot H2QP14 321
type: UnificationXref
id: H2QP14
db: uniprot

Guanine nucleotide exchange factor VAV3
type: ProteinReference
xref: uniprot Q9R0C8 35
xref: PTHR45818:SF1
organism: Mus musculus

nck
type: ProteinReference
xref: P01314
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: nck Synonym: Synonym not specified Accession: P01314
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.nck
member entity reference: Cytoplasmic protein
member entity reference: Cytoplasmic protein NCK2
member entity reference: Cytoplasmic protein NCK1

LAT
type: Protein
entity reference: LAT
feature: Y191 LAT s66 sa98 rs4
feature: Y226 LAT s66 sa98 rs5
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa98 601
feature: Y171 LAT s66 sa98 rs3
feature: Y132 LAT s66 sa98 rs2
feature: Y110 LAT s66 sa98 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PIP2
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot Q08E52 325
organism: Bos taurus

Complex (CD28/B7)
type: Complex
component stoichiometry: B7 s36 sa37 STOICHIOMETRY ID COMPLEX
component: B7
component: CD28
feature: COMPLEX BINDING FEATURE s343 a575 662
feature: COMPLEX BINDING FEATURE s343 a575 664
cellular location: cytosol

uniprot A0A1D5PR76 444
type: UnificationXref
id: A0A1D5PR76
db: uniprot

uniprot P36506 240
type: UnificationXref
id: P36506
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 7

uniprot P09693 297
type: UnificationXref
id: P09693
db: uniprot

PARTICIPANT STOICHIOMETRY r67 808
type: Stoichiometry
physical entity: Complex (NF-kappa B/I kappa B)
stoichiometric coefficient: 1.0

GTP s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot E2REK6 117
type: UnificationXref
id: E2REK6
db: uniprot

uniprot F7CY56 126
type: UnificationXref
id: F7CY56
db: uniprot

Y SLP 76 s92 sa93 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s92 sa93 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.900215879598692

PARTICIPANT STOICHIOMETRY r67 809
type: Stoichiometry
physical entity: NF-kappa B
stoichiometric coefficient: 1.0

uniprot P49186 519
type: UnificationXref
id: P49186
db: uniprot

Rac family small GTPase 1a
type: ProteinReference
xref: uniprot Q7ZSZ9 432
xref: PTHR24072:SF105
organism: Danio rerio

Y SLP 76 s96 sa97 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s96 sa97 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=Y

Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
type: ProteinReference
xref: uniprot H9FU38 467
xref: PTHR13715:SF52
organism: Macaca mulatta

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot H9FU32 217
xref: PTHR44329:SF55
organism: Macaca mulatta

uniprot F6R7U3 525
type: UnificationXref
id: F6R7U3
db: uniprot

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: uniprot A0A2I3TLP8 13
xref: PTHR45818:SF1
organism: Pan troglodytes

uniprot E2RRX6 343
type: UnificationXref
id: E2RRX6
db: uniprot

STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r105
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 849
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 848
left: IP3R
interaction type: STATE_TRANSITION
right: IP3R

ncbitaxon 9031 7
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot E2RHV6 262
type: UnificationXref
id: E2RHV6
db: uniprot

jun s25 sa26 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A1D5QKD3 232
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot E2RCV1 361
xref: PTHR10048:SF34
organism: Canis lupus familiaris

Y SLP 76 s96 sa97 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s96 sa97 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.900215879598692

CD3 gamma
type: Protein
entity reference: CD3 gamma
feature: y CD3 gamma s60 sa61 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa61 723
feature: y CD3 gamma s60 sa61 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR10570:SF5
xref: uniprot A0A1D5QRB7 436
organism: Macaca mulatta

uniprot E2RML9 415
type: UnificationXref
id: E2RML9
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q5F352 165
xref: PTHR24070:SF189
organism: Gallus gallus

CD3 eta s43 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD3 eta
stoichiometric coefficient: 2.0

uniprot Q01986 242
type: UnificationXref
id: Q01986
db: uniprot

Lck
type: Protein
entity reference: Lck
feature: Y394 Lck s479 a3 rs1
feature: ACTIVE 5
feature: Y505 Lck s479 a3 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7EI48 65
type: UnificationXref
id: F7EI48
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q02384 181
xref: PTHR23113:SF150
organism: Mus musculus

uniprot F7FHD1 66
type: UnificationXref
id: F7FHD1
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E1BMP9 187
xref: PTHR24418:SF369
organism: Bos taurus

GTP s15 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

P01299
type: UnificationXref
id: P01299
db: PANTHER Pathway Component

P01296
type: UnificationXref
id: P01296
db: PANTHER Pathway Component

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot H2QP14 321
organism: Pan troglodytes

Y SLP 76 s96 sa97 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y SLP 76 s96 sa97 rs3 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=2.3201360379273255

P01297
type: UnificationXref
id: P01297
db: PANTHER Pathway Component

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F2Z4P5 282
xref: PTHR45673:SF5
organism: Canis lupus familiaris

P01295
type: UnificationXref
id: P01295
db: PANTHER Pathway Component

uniprot Q63789 406
type: UnificationXref
id: Q63789
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6R8N3 481
xref: PTHR24356:SF190
organism: Macaca mulatta

TCR Beta s41 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR Beta
stoichiometric coefficient: 1.0

uniprot F6VAQ8 371
type: UnificationXref
id: F6VAQ8
db: uniprot

uniprot O35904 391
type: UnificationXref
id: O35904
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6VXG1 372
organism: Xenopus tropicalis

uniprot O46404 392
type: UnificationXref
id: O46404
db: uniprot

uniprot F7F5K9 157
type: UnificationXref
id: F7F5K9
db: uniprot

uniprot F1NYZ2 234
type: UnificationXref
id: F1NYZ2
db: uniprot

uniprot H2QN76 528
type: UnificationXref
id: H2QN76
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A3Q2UD13 464
organism: Gallus gallus

Y505 Lck s479 a3 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y505
feature location: Y505 Lck s479 a3 rs2 Y505
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y505
comment: MODIFICATION_RESIDUE_ANGLE=3.15

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa77 595
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y ZAP 70 s486 a373 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ZAP 70 s486 a373 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.6894200745829581

uniprot F6T2E7 314
type: UnificationXref
id: F6T2E7
db: uniprot

uniprot A0A0R4J8U1 186
type: UnificationXref
id: A0A0R4J8U1
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 144

uniprot E1C3P6 310
type: UnificationXref
id: E1C3P6
db: uniprot

Ras
type: ProteinReference
xref: P01306
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Ras
comment: ENTITY_REFERENCE_NOTES=
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: GTPase HRas
member entity reference: GTPase NRas
member entity reference: NRAS protein
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: GTPase HRas isoform 1
member entity reference: NRAS isoform 1

CD28
type: ProteinReference
xref: uniprot Q0PDN4 255
xref: PTHR11494:SF7
organism: Macaca mulatta

uniprot D4A3T0 168
type: UnificationXref
id: D4A3T0
db: uniprot

uniprot H2QFS6 385
type: UnificationXref
id: H2QFS6
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot P01111 159
xref: PTHR24070:SF189
organism: Homo sapiens

GTPase HRas
type: ProteinReference
xref: uniprot P01112 160
xref: PTHR24070:SF385
organism: Homo sapiens

uniprot F6XUP1 316
type: UnificationXref
id: F6XUP1
db: uniprot

uniprot Q63746 418
type: UnificationXref
id: Q63746
db: uniprot

uniprot F6SW23 368
type: UnificationXref
id: F6SW23
db: uniprot

CD28
type: Protein
entity reference: CD28
feature: Y CD28 s35 sa36 rs1

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

NF AT s297 a494 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=-0.0

uniprot P48455 292
type: UnificationXref
id: P48455
db: uniprot

uniprot F7G3I5 380
type: UnificationXref
id: F7G3I5
db: uniprot

uniprot F1QNG4 156
type: UnificationXref
id: F1QNG4
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__CD28-_B7-RIGHT__Complex__CD28_B7_-_r87
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 873
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 874
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 872
left: B7
left: CD28
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CD28/B7)

PARTICIPANT STOICHIOMETRY r93 835
type: Stoichiometry
physical entity: NF-AT
stoichiometric coefficient: 1.0

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P01101 199
xref: PTHR23351:SF4
organism: Mus musculus

ncbitaxon 8364 64
type: UnificationXref
id: 8364
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r93 834
type: Stoichiometry
physical entity: NF-AT
stoichiometric coefficient: 1.0

Cell division cycle 42
type: ProteinReference
xref: PTHR24072:SF337
xref: uniprot Q52WY2 500
organism: Danio rerio

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P01100 198
xref: PTHR23351:SF4
organism: Homo sapiens

I kappa B s30 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: I kappa B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 781
type: Stoichiometry
physical entity: Complex (rac/GTP/ Pak)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 780
type: Stoichiometry
physical entity: Complex (rac/GTP)
stoichiometric coefficient: 1.0

ncbitaxon 9544 23
type: UnificationXref
id: 9544
db: ncbitaxon

cdc42 s14 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cdc42
stoichiometric coefficient: 1.0

PTHR24072:SF337
type: RelationshipXref
id: PTHR24072:SF337
db: PANTHER Family
relationship type: By Homology

ncbitaxon 13616 25
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot F7HRG1 526
type: UnificationXref
id: F7HRG1
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot H2R8U9 178
xref: PTHR23113:SF168
organism: Pan troglodytes

uniprot O08908 390
type: UnificationXref
id: O08908
db: uniprot

PARTICIPANT STOICHIOMETRY r38 779
type: Stoichiometry
physical entity: Pak
stoichiometric coefficient: 1.0

uniprot F7BRK5 216
type: UnificationXref
id: F7BRK5
db: uniprot

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 112

uniprot P27986 399
type: UnificationXref
id: P27986
db: uniprot

NF-kappa B
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7BD31 22
type: UnificationXref
id: F7BD31
db: uniprot

PARTICIPANT STOICHIOMETRY r114 788
type: Stoichiometry
physical entity: Complex (LAT/Pak/ Gads/SLP-76/ WASP/vav/ nck)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r114 789
type: Stoichiometry
physical entity: Pak
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot F7H9J1 49
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Complex__Ras_GDP__-_GTP-RIGHT__GDP-_Complex__Ras_GTP_-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 862
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 861
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 863
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 864
left: Complex (Ras/GDP )
left: GTP
interaction type: STATE_TRANSITION
right: Complex (Ras/GTP)
right: GDP

HETERODIMER_ASSOCIATION_LEFT__Pak-_Complex__rac_GTP_-RIGHT__Complex__rac_GTP__Pak_-_r38
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 779
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 781
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 780
left: Pak
left: Complex (rac/GTP)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (rac/GTP/ Pak)

uniprot Q13233 53
type: UnificationXref
id: Q13233
db: uniprot

uniprot A7RPI8 101
type: UnificationXref
id: A7RPI8
db: uniprot

ncbitaxon 7955 76
type: UnificationXref
id: 7955
db: ncbitaxon

Rac family small GTPase 2
type: ProteinReference
xref: uniprot Q5U1Y2 427
xref: PTHR24072:SF169
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r52 889
type: Stoichiometry
physical entity: jun
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF2
xref: uniprot A0A1D5Q8S7 274
organism: Macaca mulatta

ncbitaxon 39947 144
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot F6YCI3 176
type: UnificationXref
id: F6YCI3
db: uniprot

PARTICIPANT STOICHIOMETRY r52 892
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r52 891
type: Stoichiometry
physical entity: jun
stoichiometric coefficient: 1.0

…
type: Stoichiometry
physical entity: CD28
stoichiometric coefficient: 2.0

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r52 890
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_Complex__LAT_PLC_gamma__Gads_SLP_76_-RIGHT__ADP-_Complex__LAT_PLC_gamma__Gads_SLP_76_-_r107
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r107 840
participant stoichiometry: PARTICIPANT STOICHIOMETRY r107 843
participant stoichiometry: PARTICIPANT STOICHIOMETRY r107 842
participant stoichiometry: PARTICIPANT STOICHIOMETRY r107 841
left: Complex (LAT/PLC-gamma/ Gads/SLP-76)
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: Complex (LAT/PLC-gamma/ Gads/SLP-76)

Complex (TCR Beta/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)
type: Complex
component stoichiometry: CD3 delta s61 sa62 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCR alpha s65 sa66 STOICHIOMETRY ID COMPLEX
component stoichiometry: ZAP 70 s64 sa65 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 86STOICHIOMETRY ID COMPLEX
component stoichiometry: CD3 gamma s60 sa61 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCR Beta s59 sa60 STOICHIOMETRY ID COMPLEX
component: TCR zeta
component: CD3 gamma
component: TCR Beta
component: TCR alpha
component: CD3 delta
component: ZAP-70
component: CD3 eta
feature: COMPLEX BINDING FEATURE s398 a648 726
feature: COMPLEX BINDING FEATURE s398 a648 730
feature: COMPLEX BINDING FEATURE s398 a648 732
feature: COMPLEX BINDING FEATURE s398 a648 720
feature: COMPLEX BINDING FEATURE s398 a648 728
feature: COMPLEX BINDING FEATURE s398 a648 722
feature: COMPLEX BINDING FEATURE s398 a648 724
cellular location: cytosol

Complex (TCR Beta/MHC-antigen/ TCR alpha/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta)
type: Complex
component stoichiometry: TCR alpha s54 sa55 STOICHIOMETRY ID COMPLEX
component stoichiometry: CD3 gamma s55 sa56 STOICHIOMETRY ID COMPLEX
component stoichiometry: CD3 delta s56 sa57 STOICHIOMETRY ID COMPLEX
component stoichiometry: MHC antigen s53 sa54 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 85STOICHIOMETRY ID COMPLEX
component stoichiometry: TCR Beta s52 sa53 STOICHIOMETRY ID COMPLEX
component: TCR Beta
component: TCR alpha
component: CD3 delta
component: CD3 gamma
component: TCR zeta
component: MHC -antigen
component: CD3 eta
feature: COMPLEX BINDING FEATURE s384 a629 644
feature: COMPLEX BINDING FEATURE s384 a629 650
feature: COMPLEX BINDING FEATURE s384 a629 652
feature: COMPLEX BINDING FEATURE s384 a629 656
feature: COMPLEX BINDING FEATURE s384 a629 654
feature: COMPLEX BINDING FEATURE s384 a629 648
feature: COMPLEX BINDING FEATURE s384 a629 646
cellular location: cytosol

uniprot G7MGQ5 383
type: UnificationXref
id: G7MGQ5
db: uniprot

ncbitaxon 10228 112
type: UnificationXref
id: 10228
db: ncbitaxon

Gads
type: Protein
entity reference: Gads
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa92 611
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P01337
type: UnificationXref
id: P01337
db: PANTHER Pathway Component

P01336
type: UnificationXref
id: P01336
db: PANTHER Pathway Component

P01335
type: UnificationXref
id: P01335
db: PANTHER Pathway Component

uniprot P62152 140
type: UnificationXref
id: P62152
db: uniprot

NF kappa B inhibitor alpha (Fragment)
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q8WNW7 419
organism: Bos taurus

uniprot O35531 529
type: UnificationXref
id: O35531
db: uniprot

Guanine nucleotide exchange factor VAV2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot Q60992 34
organism: Mus musculus

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: uniprot P26450 398
xref: PTHR10155:SF3
organism: Mus musculus

uniprot H9FU32 217
type: UnificationXref
id: H9FU32
db: uniprot

Calmodulin
type: ProteinReference
xref: uniprot O16305 130
organism: Caenorhabditis elegans

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Ras_GTP__Raf_MEK_-RIGHT__Complex__Ras_GTP__Raf_-_MEK-_r102
controller: Raf

uniprot Q3ZCM0 204
type: UnificationXref
id: Q3ZCM0
db: uniprot

uniprot A0A1D5R1G4 414
type: UnificationXref
id: A0A1D5R1G4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZEW0 115
xref: PTHR23050:SF245
organism: Branchiostoma floridae

PLC-gamma
type: Protein
entity reference: PLC-gamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s94 sa95 617
feature: PLC gamma s94 sa95 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r16 765
type: Stoichiometry
physical entity: LAT
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZEW2 116
organism: Branchiostoma floridae

PARTICIPANT STOICHIOMETRY r16 764
type: Stoichiometry
physical entity: LAT
stoichiometric coefficient: 1.0

TCR zeta
type: Protein
entity reference: TCR zeta
feature: Y TCR zeta s63 sa64 rs2
feature: Y TCR zeta s63 sa64 rs1
feature: Y TCR zeta s63 sa64 rs3
feature: Y TCR zeta s63 sa64 rs5
feature: Y TCR zeta s63 sa64 rs6
feature: Y TCR zeta s63 sa64 rs4

uniprot A0A2I3TRY9 354
type: UnificationXref
id: A0A2I3TRY9
db: uniprot

PIP2
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa32 675
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r114 791
type: Stoichiometry
physical entity: WASP
stoichiometric coefficient: 1.0

uniprot P42336 401
type: UnificationXref
id: P42336
db: uniprot

PARTICIPANT STOICHIOMETRY r114 790
type: Stoichiometry
physical entity: Complex (LAT/Gads/ SLP-76/vav/ nck)
stoichiometric coefficient: 1.0

PTHR24418:SF39
type: RelationshipXref
id: PTHR24418:SF39
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__cdc42_GDP_-_GTP-RIGHT__GDP-_Complex__cdc42_GTP_-_r37
controller: Complex (LAT/Gads/ SLP-76/vav/ nck)

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s511 sa13 563
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P31938 239
type: UnificationXref
id: P31938
db: uniprot

Y171 LAT s89 sa90 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y171
feature location: Y171 LAT s89 sa90 rs3 Y171
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7720410517750427
comment: MODIFICATION_RESIDUE_NAME=Y171

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 521
xref: PTHR24055:SF172
organism: Mus musculus

P01315
type: UnificationXref
id: P01315
db: PANTHER Pathway Component

Csk
type: Protein
entity reference: Csk
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P01314
type: UnificationXref
id: P01314
db: PANTHER Pathway Component

P01313
type: UnificationXref
id: P01313
db: PANTHER Pathway Component

uniprot E1BMP9 187
type: UnificationXref
id: E1BMP9
db: uniprot

uniprot Q920L0 347
type: UnificationXref
id: Q920L0
db: uniprot

P01319
type: UnificationXref
id: P01319
db: PANTHER Pathway Component

P01318
type: UnificationXref
id: P01318
db: PANTHER Pathway Component

PTHR45673:SF2
type: RelationshipXref
id: PTHR45673:SF2
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot P16298 287
organism: Homo sapiens

P01317
type: UnificationXref
id: P01317
db: PANTHER Pathway Component

Y394 Lck s480 a18 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y394
feature location: Y394 Lck s480 a18 rs1 Y394
comment: MODIFICATION_RESIDUE_NAME=Y394
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.02

uniprot A0A3Q1MLL9 523
type: UnificationXref
id: A0A3Q1MLL9
db: uniprot

ncbitaxon 9615 19
type: UnificationXref
id: 9615
db: ncbitaxon

B7
type: Protein
entity reference: B7
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F1MX21 465
xref: PTHR13715:SF52
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r103 854
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r103 853
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 1.0

Vav guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot D3ZYG0 14
organism: Rattus norvegicus

GTP s83 sa81 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PTHR45673:SF5
type: RelationshipXref
id: PTHR45673:SF5
db: PANTHER Family
relationship type: By Homology

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 152

y CD3 eta s57 sa58 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 eta s57 sa58 rs1 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=3.91785828020355

PTHR45673:SF7
type: RelationshipXref
id: PTHR45673:SF7
db: PANTHER Family
relationship type: By Homology

P01322
type: UnificationXref
id: P01322
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot C3ZEV9 113
organism: Branchiostoma floridae

P01323
type: UnificationXref
id: P01323
db: PANTHER Pathway Component

P01320
type: UnificationXref
id: P01320
db: PANTHER Pathway Component

P01321
type: UnificationXref
id: P01321
db: PANTHER Pathway Component

uniprot F6W7C8 373
type: UnificationXref
id: F6W7C8
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot H2R5K3 51
organism: Pan troglodytes

P01325
type: UnificationXref
id: P01325
db: PANTHER Pathway Component

P01324
type: UnificationXref
id: P01324
db: PANTHER Pathway Component

P01327
type: UnificationXref
id: P01327
db: PANTHER Pathway Component

P01326
type: UnificationXref
id: P01326
db: PANTHER Pathway Component

uniprot F6RBZ7 495
type: UnificationXref
id: F6RBZ7
db: uniprot

P01329
type: UnificationXref
id: P01329
db: PANTHER Pathway Component

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

TCR-responsive genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

y CD3 eta s57 sa58 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY y
feature location: y CD3 eta s57 sa58 rs2 y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=y
comment: MODIFICATION_RESIDUE_ANGLE=2.412924694611101

P01330
type: UnificationXref
id: P01330
db: PANTHER Pathway Component

P01331
type: UnificationXref
id: P01331
db: PANTHER Pathway Component

P01332
type: UnificationXref
id: P01332
db: PANTHER Pathway Component

P01333
type: UnificationXref
id: P01333
db: PANTHER Pathway Component

P01334
type: UnificationXref
id: P01334
db: PANTHER Pathway Component

uniprot A0A1D5R8E9 333
type: UnificationXref
id: A0A1D5R8E9
db: uniprot

I kappa B
type: Protein
entity reference: I kappa B
feature: I kappa B s30 sa31 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa31 703
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7A567 496
type: UnificationXref
id: F7A567
db: uniprot

P01300
type: UnificationXref
id: P01300
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F6S9S9 235
organism: Monodelphis domestica

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot G3X7B5 485
type: UnificationXref
id: G3X7B5
db: uniprot

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

uniprot Q64143 407
type: UnificationXref
id: Q64143
db: uniprot

Jnk
type: Protein
entity reference: Jnk
feature: Jnk s251 a407 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__ATP-_Complex__CD28_B7_-RIGHT__ADP-_Complex__CD28_B7_-_r88
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 867
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 866
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 865
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 868
left: Complex (CD28/B7)
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: Complex (CD28/B7)

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__NF_kappa_B_I_kappa_B_-RIGHT__NF_kappa_B-_I_kappa_B-_r67
controller: IKK

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5QUZ8 58
xref: PTHR24055:SF203
organism: Macaca mulatta

uniprot P52735 33
type: UnificationXref
id: P52735
db: uniprot

uniprot Q62925 54
type: UnificationXref
id: Q62925
db: uniprot

uniprot Q13094 345
type: UnificationXref
id: Q13094
db: uniprot

P01312
type: UnificationXref
id: P01312
db: PANTHER Pathway Component

P01311
type: UnificationXref
id: P01311
db: PANTHER Pathway Component

P01310
type: UnificationXref
id: P01310
db: PANTHER Pathway Component

TCR zeta s44 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCR zeta
stoichiometric coefficient: 2.0

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q9WTQ0 306
organism: Rattus norvegicus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 133

PARTICIPANT STOICHIOMETRY r85 885
type: Stoichiometry
physical entity: MEKK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r85 884
type: Stoichiometry
physical entity: MEKK
stoichiometric coefficient: 1.0

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__MEKK-RIGHT__MEKK-_r85
controller: Complex (PIP3/Akt)

P01308
type: UnificationXref
id: P01308
db: PANTHER Pathway Component

PTHR23050:SF245
type: RelationshipXref
id: PTHR23050:SF245
db: PANTHER Family
relationship type: By Homology

P01309
type: UnificationXref
id: P01309
db: PANTHER Pathway Component

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q05144 425
organism: Mus musculus

P01306
type: UnificationXref
id: P01306
db: PANTHER Pathway Component

P01307
type: UnificationXref
id: P01307
db: PANTHER Pathway Component

uniprot O00459 389
type: UnificationXref
id: O00459
db: uniprot

P01304
type: UnificationXref
id: P01304
db: PANTHER Pathway Component

P01305
type: UnificationXref
id: P01305
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__ATP-_PIP-RIGHT__ADP-_PIP2-_r81
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 753
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 755
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 754
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 752
left: ATP
left: PIP
interaction type: STATE_TRANSITION
right: ADP
right: PIP2

P01302
type: UnificationXref
id: P01302
db: PANTHER Pathway Component

P01303
type: UnificationXref
id: P01303
db: PANTHER Pathway Component

uniprot Q9XT09 249
type: UnificationXref
id: Q9XT09
db: uniprot

uniprot F6XT65 236
type: UnificationXref
id: F6XT65
db: uniprot

uniprot P42081 531
type: UnificationXref
id: P42081
db: uniprot

TCR alpha
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s75 sa73 559
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Csk
type: ProteinReference
xref: P01304
standard name: C-terminal Src kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.Csk
comment: ENTITY_REFERENCE_NOTES= Long Name: Csk Synonym: c-src kinase Accession: P01304
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase CSK

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 102

Y394 Lck s17 a19 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y394
feature location: Y394 Lck s17 a19 rs1 Y394
comment: MODIFICATION_RESIDUE_NAME=Y394
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.02

ERK
type: ProteinReference
xref: P01300
standard name: Extracellular signal-regulated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: ERK Synonym: Estrogen Regulated Kinase Accession: P01300
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.ERK
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Uncharacterized protein

uniprot F7EJL2 24
type: UnificationXref
id: F7EJL2
db: uniprot

PIP3 s33 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

CD28
type: Complex
component stoichiometry: CD28 s37 sa38 STOICHIOMETRY ID COMPLEX
component: CD28
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa38 667
cellular location: cytosol

uniprot Q9TTF2 535
type: UnificationXref
id: Q9TTF2
db: uniprot

uniprot P27870 31
type: UnificationXref
id: P27870
db: uniprot

uniprot P63085 72
type: UnificationXref
id: P63085
db: uniprot

uniprot O75791 443
type: UnificationXref
id: O75791
db: uniprot

uniprot P23726 396
type: UnificationXref
id: P23726
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QLB4 67
xref: PTHR24055:SF203
organism: Pan troglodytes

Y132 LAT s406 a275 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y132
feature location: Y132 LAT s406 a275 rs2 Y132
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3298847729394225
comment: MODIFICATION_RESIDUE_NAME=Y132

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot Q04982 228
xref: PTHR44329:SF47
organism: Gallus gallus

uniprot F1PXS7 61
type: UnificationXref
id: F1PXS7
db: uniprot

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

uniprot O77628 196
type: UnificationXref
id: O77628
db: uniprot

eco ECO:0000316 8
type: UnificationXref
id: ECO:0000316
db: eco

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF2
xref: uniprot A0A2I3SD30 277
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF427
xref: uniprot F7D7P2 127
organism: Monodelphis domestica

nck
type: Protein
entity reference: nck
feature: COMPLEX PARTICIPANT BINDING FEATURE s103 sa107 587
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P02599 132
type: UnificationXref
id: P02599
db: uniprot

uniprot A0A3Q1M353 212
type: UnificationXref
id: A0A3Q1M353
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5Q5Z6 57
xref: PTHR24055:SF393
organism: Macaca mulatta

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa15 751
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

MHC -antigen
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__ATP-_Complex__TCR_Beta_CD3_gamma__CD3_delta_CD3_eta__TCR_zeta_ZAP_70__TCR_alpha_-RIGHT__ADP-_Complex__CD3_gamma_TCR_Beta__CD3_delta_CD3_eta__TCR_zeta_ZAP_70__TCR_alpha_-_r99
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 807
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 806
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 804
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 805
left: Complex (TCR Beta/CD3 gamma/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)
left: ATP
interaction type: STATE_TRANSITION
right: Complex (CD3 gamma/TCR Beta/ CD3 delta/CD3 eta/ TCR zeta/ZAP-70/ TCR alpha)
right: ADP

NFKB inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot H2Q867 416
organism: Pan troglodytes

uniprot F7FDA0 379
type: UnificationXref
id: F7FDA0
db: uniprot

uniprot P53349 52
type: UnificationXref
id: P53349
db: uniprot

uniprot Q00609 533
type: UnificationXref
id: Q00609
db: uniprot

uniprot E2RPB0 364
type: UnificationXref
id: E2RPB0
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

CD28 molecule
type: ProteinReference
xref: PTHR11494:SF7
xref: uniprot Q9GKP3 257
organism: Canis lupus familiaris

uniprot E2RKR0 450
type: UnificationXref
id: E2RKR0
db: uniprot

TRANSPORT
type: InteractionVocabulary

Complex (SOS/Grb2)
type: Complex
component stoichiometry: SOS s27 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s28 sa29 STOICHIOMETRY ID COMPLEX
component: Grb2
component: SOS
feature: COMPLEX BINDING FEATURE s309 a511 672
feature: COMPLEX BINDING FEATURE s309 a511 670
cellular location: cytosol

Calmodulin
type: ProteinReference
xref: PTHR23050:SF424
xref: uniprot Q6PI52 148
organism: Danio rerio

TRANSPORT_LEFT__Jnk-RIGHT__Jnk-_r91
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 839
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 838
left: Jnk
interaction type: TRANSPORT
right: Jnk

PIP2 s31 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

LAT
type: ProteinReference
xref: P01325
comment: ENTITY_REFERENCE_ID_DESC=T cell activation.PROTEIN.GENERIC.LAT
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: LAT Synonym: Linker for Activation of T cells,pp36/38 Accession: P01325
member entity reference: Linker for activation of T-cells family member 1

uniprot A0A3Q2UD13 464
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

fos
type: Protein
entity reference: fos
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa27 643
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot B0BLZ8 279
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Ras_GDP__-_GTP-RIGHT__GDP-_Complex__Ras_GTP_-_r24
controller: Complex (LAT/SLP-76/ Grb2/SOS/ Gads/PLC-gamma)

uniprot Q6PF93 408
type: UnificationXref
id: Q6PF93
db: uniprot

Y ZAP 70 s64 sa65 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ZAP 70 s64 sa65 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.6894200745829581

uniprot Q60787 346
type: UnificationXref
id: Q60787
db: uniprot

PARTICIPANT STOICHIOMETRY r83 893
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot P60952 498
type: UnificationXref
id: P60952
db: uniprot

PARTICIPANT STOICHIOMETRY r83 895
type: Stoichiometry
physical entity: Complex (PIP2/Akt)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r83 894
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

MHC antigen s46 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MHC -antigen
stoichiometric coefficient: 1.0

Complex (LAT/Pak/ Gads/SLP-76/ WASP/vav/ nck)
type: Complex
component stoichiometry: SLP 76 s100 sa104 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gads s99 sa103 STOICHIOMETRY ID COMPLEX
component stoichiometry: vav s102 sa106 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pak s98 sa102 STOICHIOMETRY ID COMPLEX
component stoichiometry: nck s103 sa107 STOICHIOMETRY ID COMPLEX
component stoichiometry: WASP s101 sa105 STOICHIOMETRY ID COMPLEX
component stoichiometry: LAT s97 sa101 STOICHIOMETRY ID COMPLEX
component: nck
component: vav
component: WASP
component: SLP-76
component: Pak
component: LAT
component: Gads
feature: COMPLEX BINDING FEATURE s471 a743 586
feature: COMPLEX BINDING FEATURE s471 a743 576
feature: COMPLEX BINDING FEATURE s471 a743 582
feature: COMPLEX BINDING FEATURE s471 a743 578
feature: COMPLEX BINDING FEATURE s471 a743 580
feature: COMPLEX BINDING FEATURE s471 a743 574
feature: COMPLEX BINDING FEATURE s471 a743 584
cellular location: cytosol

ncbitaxon 5664 146
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot Q02111 304
type: UnificationXref
id: Q02111
db: uniprot

CD3 gamma
type: Protein
entity reference: CD3 gamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa67 547
feature: y CD3 gamma s69 sa67 rs1
feature: y CD3 gamma s69 sa67 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
type: ProteinReference
xref: uniprot F7BZL6 375
xref: PTHR10155:SF3
organism: Macaca mulatta

uniprot Q5RKN6 88
type: UnificationXref
id: Q5RKN6
db: uniprot

Complex (rac/GTP)
type: Complex
component stoichiometry: rac s510 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s113 sa11 STOICHIOMETRY ID COMPLEX
component: rac
component: GTP
feature: COMPLEX BINDING FEATURE s491 a434 712
feature: ACTIVE 5
feature: COMPLEX BINDING FEATURE s491 a434 714
cellular location: cytosol

uniprot E2RNA9 451
type: UnificationXref
id: E2RNA9
db: uniprot

PLC gamma s81 sa79 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot O46404 392
xref: PTHR10155:SF2
organism: Bos taurus

uniprot F6S9S9 235
type: UnificationXref
id: F6S9S9
db: uniprot

uniprot A7RPN8 103
type: UnificationXref
id: A7RPN8
db: uniprot

Y ZAP 70 s64 sa65 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ZAP 70 s64 sa65 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.496387147055939
comment: MODIFICATION_RESIDUE_NAME=Y

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa28 671
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SLP-76
type: Protein
entity reference: SLP-76
feature: Y SLP 76 s106 sa110 rs2
feature: Y SLP 76 s106 sa110 rs3
feature: Y SLP 76 s106 sa110 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s106 sa110 541
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot F6XUP1 316
organism: Macaca mulatta

Ras s109 sa84 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Cytoplasmic protein
type: ProteinReference
xref: uniprot E2RHV6 262
xref: PTHR19969:SF16
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot F7DKU1 286
organism: Monodelphis domestica

TRANSPORT_LEFT__NF_AT-RIGHT__NF_AT-_r93
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 835
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 834
left: NF-AT
interaction type: TRANSPORT
right: NF-AT

uniprot Q6F332 147
type: UnificationXref
id: Q6F332
db: uniprot

DISSOCIATION_LEFT__Complex__LAT_PLC_gamma__Gads_SLP_76_-RIGHT__Complex__LAT_Gads__SLP_76_-_PLC_gamma-_r110
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r110 823
participant stoichiometry: PARTICIPANT STOICHIOMETRY r110 824
participant stoichiometry: PARTICIPANT STOICHIOMETRY r110 822
left: Complex (LAT/PLC-gamma/ Gads/SLP-76)
interaction type: DISSOCIATION
right: Complex (LAT/Gads/ SLP-76)
right: PLC-gamma

Complex (Gads/SLP-76)
type: Complex
component stoichiometry: Gads s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: SLP 76 s2 sa2 STOICHIOMETRY ID COMPLEX
component: Gads
component: SLP-76
feature: COMPLEX BINDING FEATURE s204 a302 566
feature: COMPLEX BINDING FEATURE s204 a302 564
cellular location: cytosol

uniprot F1N8W8 313
type: UnificationXref
id: F1N8W8
db: uniprot

uniprot F7HLC7 382
type: UnificationXref
id: F7HLC7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PIP-RIGHT__ADP-_PIP2-_r81
controller: PI3K

Jnk
type: Protein
entity reference: Jnk
feature: Jnk s250 a405 rs1
feature: ACTIVE 5
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PIK3CG isoform 1
type: ProteinReference
xref: uniprot A0A2J8QY32 355
xref: PTHR10048:SF34
organism: Pan troglodytes

SLP 76 s96 sa97 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SLP-76
stoichiometric coefficient: 1.0

Complex (jun/fos)
type: Complex
component stoichiometry: jun s25 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: fos s26 sa27 STOICHIOMETRY ID COMPLEX
component: jun
component: fos
feature: COMPLEX BINDING FEATURE s306 a506 642
feature: COMPLEX BINDING FEATURE s306 a506 640
cellular location: nucleus

Monosiga brevicollis
type: BioSource
xref: ncbitaxon 81824 110

PARTICIPANT STOICHIOMETRY r5 763
type: Stoichiometry
physical entity: Lck
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 762
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 761
type: Stoichiometry
physical entity: Lck
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 760
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q9QY78 462
type: UnificationXref
id: Q9QY78
db: uniprot

GO GO:0005783 3
type: UnificationXref
id: GO:0005783
db: GO

uniprot Q61036 328
type: UnificationXref
id: Q61036
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7FAI7 188
xref: PTHR24418:SF369
organism: Macaca mulatta