uniprot Q93341 93
type: UnificationXref
id: Q93341
db: uniprot

ncbitaxon 243230 12
type: UnificationXref
id: 243230
db: ncbitaxon

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot P48596 142
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__dihydroneopterin-RIGHT__glycolaldehyde-_2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 167
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 168
left: dihydroneopterin
interaction type: STATE_TRANSITION
right: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
right: glycolaldehyde

Probable dihydrofolate synthetase
type: ProteinReference
xref: uniprot Q9UTD0 104
organism: Schizosaccharomyces pombe

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 7

uniprot Q94465 156
type: UnificationXref
id: Q94465
db: uniprot

7,8-dihydroneopterin aldolase
type: ProteinReference
xref: uniprot Q8A5T9 8
organism: Bacteroides thetaiotaomicron

STATE_TRANSITION_LEFT__4_amino_4_deoxychorismate-RIGHT__pyruvate-_p_aminobenzoate-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 196
left: 4-amino-4-deoxychorismate
interaction type: STATE_TRANSITION
right: p-aminobenzoate
right: pyruvate

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dihydroneopterin_triphosphate-RIGHT__PPi-_dihydroneopterin_phosphate-_r2
controller: Dihydroneopterin triphosphate pyrophosphohydrolase

uniprot P07607 48
type: UnificationXref
id: P07607
db: uniprot

uniprot Q8ZWW5 154
type: UnificationXref
id: Q8ZWW5
db: uniprot

ncbitaxon 6239 73
type: UnificationXref
id: 6239
db: ncbitaxon

STATE_TRANSITION_LEFT__p_aminobenzoate-_2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine_diphosphate-RIGHT__PPi-_7,8_dihydropteroate-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 206
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 204
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 205
left: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
left: p-aminobenzoate
interaction type: STATE_TRANSITION
right: PPi
right: 7,8-dihydropteroate

Dihydrofolate reductase 2, mitochondrial
type: ProteinReference
xref: uniprot Q86XF0 84
organism: Homo sapiens

ncbitaxon 189518 120
type: UnificationXref
id: 189518
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_glutamate-_7,8_dihydropteroate-RIGHT__7,8_dihydrofolate-_ADP-_PO4-_r9
controller: Dihydrofolate synthase

ncbitaxon 9615 132
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot P11045 57
type: UnificationXref
id: P11045
db: uniprot

STATE_TRANSITION_LEFT__GTP-_2_H2O-RIGHT__dihydroneopterin_triphosphate-_2_H2O-_formate-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 180
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 179
left: 2 H2O
left: GTP
interaction type: STATE_TRANSITION
right: 2 H2O
right: dihydroneopterin triphosphate
right: formate

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot P51599 143
organism: Neurospora crassa

Mus musculus
type: BioSource
xref: ncbitaxon 10090 40

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot O66603 139
organism: Aquifex aeolicus

uniprot F6ZRA0 23
type: UnificationXref
id: F6ZRA0
db: uniprot

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P17719 60
organism: Drosophila melanogaster

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot Q9X8I3 162
organism: Streptomyces coelicolor

Dihydroneopterin aldolase
type: ProteinReference
xref: uniprot Q9X8I0 14
organism: Streptomyces coelicolor

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 45

Dihydropteroate synthase
type: ProteinReference
xref: uniprot Q9X8H8 128
organism: Streptomyces coelicolor

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 36

uniprot Q09509 72
type: UnificationXref
id: Q09509
db: uniprot

PARTICIPANT STOICHIOMETRY r4 169
type: Stoichiometry
physical entity: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 168
type: Stoichiometry
physical entity: glycolaldehyde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 167
type: Stoichiometry
physical entity: dihydroneopterin
stoichiometric coefficient: 1.0

uniprot Q6IQV5 150
type: UnificationXref
id: Q6IQV5
db: uniprot

uniprot Q55759 148
type: UnificationXref
id: Q55759
db: uniprot

uniprot F6ZD25 136
type: UnificationXref
id: F6ZD25
db: uniprot

uniprot Q9RXY6 125
type: UnificationXref
id: Q9RXY6
db: uniprot

formate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__7,8_dihydrofolate-_NADPH-RIGHT__NADP-_tetrahydrofolate-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 188
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 189
left: NADPH
left: 7,8-dihydrofolate
interaction type: STATE_TRANSITION
right: tetrahydrofolate
right: NADP

Thymidylate synthase 2
type: ProteinReference
xref: uniprot P11044 56
organism: Bacillus subtilis

uniprot I6Y0R5 27
type: UnificationXref
id: I6Y0R5
db: uniprot

uniprot Q19980 147
type: UnificationXref
id: Q19980
db: uniprot

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P11045 57
organism: Bacillus subtilis

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 30

ncbitaxon 9913 42
type: UnificationXref
id: 9913
db: ncbitaxon

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 86

Dihydrofolate synthetase
type: ProteinReference
xref: uniprot Q1K7T9 75
organism: Neurospora crassa

uniprot Q7NKJ0 6
type: UnificationXref
id: Q7NKJ0
db: uniprot

uniprot Q9SFV7 161
type: UnificationXref
id: Q9SFV7
db: uniprot

uniprot Q8A1L5 118
type: UnificationXref
id: Q8A1L5
db: uniprot

uniprot Q9HZA8 94
type: UnificationXref
id: Q9HZA8
db: uniprot

uniprot Q6P045 80
type: UnificationXref
id: Q6P045
db: uniprot

uniprot Q05915 146
type: UnificationXref
id: Q05915
db: uniprot

uniprot Q9HYG8 158
type: UnificationXref
id: Q9HYG8
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: uniprot Q8RGP6 90
organism: Fusobacterium nucleatum

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RR67 101
type: UnificationXref
id: Q9RR67
db: uniprot

uniprot Q8TK98 122
type: UnificationXref
id: Q8TK98
db: uniprot

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9598 25
type: UnificationXref
id: 9598
db: ncbitaxon

GTP cyclohydrolase
type: Protein
entity reference: GTP cyclohydrolase
comment: SPECIES_TYPE=PROTEIN

uniprot P07807 49
type: UnificationXref
id: P07807
db: uniprot

7,8-dihydrofolate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P0CS12 54
type: UnificationXref
id: P0CS12
db: uniprot

uniprot P9WN57 145
type: UnificationXref
id: P9WN57
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SNN4 22
organism: Macaca mulatta

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 25

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 10090 40
type: UnificationXref
id: 10090
db: ncbitaxon

7,8-dihydroneopterin aldolase
type: ProteinReference
xref: uniprot Q9RXY5 11
organism: Deinococcus radiodurans

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot Q05915 146
organism: Mus musculus

Dihydropteroate synthase
type: ProteinReference
xref: uniprot Q9RXY6 125
organism: Deinococcus radiodurans

ncbitaxon 100226 15
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot Q05932 69
type: UnificationXref
id: Q05932
db: uniprot

ncbitaxon 243090 117
type: UnificationXref
id: 243090
db: ncbitaxon

uniprot Q86XF0 84
type: UnificationXref
id: Q86XF0
db: uniprot

Folylpolyglutamate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q05932 69
organism: Homo sapiens

GTP cyclohydrolase 2
type: ProteinReference
xref: uniprot Q6IQV5 150
organism: Danio rerio

Dihydrofolate reductase
type: ProteinReference
xref: uniprot A2BGQ1 18
organism: Danio rerio

glycine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Folylpolyglutamate synthase/dihydrofolate synthase
type: ProteinReference
xref: uniprot Q9WY13 107
organism: Thermotoga maritima

Thymidylate synthase
type: ProteinReference
xref: uniprot P04818 43
organism: Homo sapiens

Dihydrofolate synthase/folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q8IE69 87
organism: Plasmodium falciparum

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q9L1G4 98
organism: Streptomyces coelicolor

Dihydropteroate synthase
type: ProteinReference
xref: uniprot Q8TK98 122
organism: Methanosarcina acetivorans

uniprot O67833 31
type: UnificationXref
id: O67833
db: uniprot

Dihydropteroate synthase
type: ProteinReference
xref: uniprot Q9WXP7 127
organism: Thermotoga maritima

ncbitaxon 39947 77
type: UnificationXref
id: 39947
db: ncbitaxon

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot Q94465 156
organism: Dictyostelium discoideum

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot A0A1D5RHP4 16
organism: Macaca mulatta

AGAP010457-PA
type: ProteinReference
xref: uniprot Q7QDW7 83
organism: Anopheles gambiae

uniprot Q8RH43 153
type: UnificationXref
id: Q8RH43
db: uniprot

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dihydropteroate synthase
type: ProteinReference
xref: uniprot Q9FBL7 124
organism: Streptomyces coelicolor

uniprot H2QR61 26
type: UnificationXref
id: H2QR61
db: uniprot

4-amino-4-deoxychorismate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dihydrofolate reductase
type: ProteinReference
xref: uniprot Q07801 70
organism: Cryptococcus neoformans

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot P07382 46
organism: Leishmania major

STATE_TRANSITION_LEFT___chorismate-_glutamine-RIGHT__4_amino_4_deoxychorismate-_glutamate-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 202
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 200
left: chorismate
left: glutamine
interaction type: STATE_TRANSITION
right: glutamate
right: 4-amino-4-deoxychorismate

uniprot Q9N588 99
type: UnificationXref
id: Q9N588
db: uniprot

uniprot Q9I6F1 97
type: UnificationXref
id: Q9I6F1
db: uniprot

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thymidylate synthase
type: ProteinReference
xref: uniprot O76511 35
organism: Drosophila melanogaster

uniprot P9WFR9 65
type: UnificationXref
id: P9WFR9
db: uniprot

Dihydrofolate synthase/folylpolyglutamate synthase
type: ProteinReference
xref: uniprot P08192 50
organism: Escherichia coli

Dihydrofolate reductase
type: ProteinReference
xref: uniprot Q920D2 92
organism: Rattus norvegicus

uniprot Q12676 74
type: UnificationXref
id: Q12676
db: uniprot

uniprot F4JYE9 21
type: UnificationXref
id: F4JYE9
db: uniprot

STATE_TRANSITION_LEFT__dihydroneopterin_phosphate-RIGHT__PO4-_dihydroneopterin-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 170
left: dihydroneopterin phosphate
interaction type: STATE_TRANSITION
right: PO4
right: dihydroneopterin

uniprot Q9X8H8 128
type: UnificationXref
id: Q9X8H8
db: uniprot

Dihydrofolate synthase/folylpolyglutamate synthase
type: ProteinReference
xref: uniprot I6Y0R5 27
organism: Mycobacterium tuberculosis

PARTICIPANT STOICHIOMETRY r3 171
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 3

PARTICIPANT STOICHIOMETRY r3 170
type: Stoichiometry
physical entity: dihydroneopterin phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 172
type: Stoichiometry
physical entity: dihydroneopterin
stoichiometric coefficient: 1.0

Dihydrofolate synthase
type: ProteinReference
xref: P02943
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydrofolate synthase Synonym: Synonym not specified Accession: P02943
comment: ENTITY_REFERENCE_ID_DESC=Tetrahydrofolate biosynthesis.PROTEIN.GENERIC.Dihydrofolate synthase
member entity reference: AGAP010278-PA
member entity reference: Thymidylate synthase
member entity reference: Dihydrofolate synthase/folylpolyglutamate synthase
member entity reference: Dihydrofolate reductase
member entity reference: Bifunctional dihydrofolate reductase-thymidylate synthase
member entity reference: Folylpolyglutamate synthase, mitochondrial
member entity reference: Uncharacterized protein
member entity reference: Putative dihydrofolate reductase
member entity reference: Folylpolyglutamate synthase
member entity reference: Dihydrofolate synthetase
member entity reference: Putative folylpolyglutamate synthase
member entity reference: Folylpolyglutamate synthetase
member entity reference: Probable thymidylate synthase
member entity reference: Probable folylpolyglutamate synthase
member entity reference: Thymidylate synthase ThyA
member entity reference: AGAP010457-PA
member entity reference: Folyl-polyglutamate synthetase
member entity reference: Probable dihydrofolate synthetase
member entity reference: DHFR isoform 1
member entity reference: Fibronectin 1
member entity reference: Bifunctional dihydrofolate reductase-thymidylate synthase 1
member entity reference: Thymidylate synthetase
member entity reference: Folylpolyglutamate synthase/dihydrofolate synthase
member entity reference: Thymidylate synthase 1
member entity reference: Dihydrofolate reductase 2, mitochondrial
member entity reference: Thymidylate synthase 2

Bos taurus
type: BioSource
xref: ncbitaxon 9913 42

7,8-dihydropteroate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 17

uniprot A8X8K8 129
type: UnificationXref
id: A8X8K8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine-RIGHT__2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine_diphosphate-_ADP-_r5
controller: 5-Hydroxymethyl-7,8-dihydropteridine pyrophosphokinase

uniprot Q8I5H7 152
type: UnificationXref
id: Q8I5H7
db: uniprot

uniprot Q9RXY5 11
type: UnificationXref
id: Q9RXY5
db: uniprot

ncbitaxon 185431 79
type: UnificationXref
id: 185431
db: ncbitaxon

Thymidylate synthase
type: ProteinReference
xref: uniprot P07607 48
organism: Mus musculus

uniprot O76511 35
type: UnificationXref
id: O76511
db: uniprot

uniprot Q05762 67
type: UnificationXref
id: Q05762
db: uniprot

uniprot O13774 138
type: UnificationXref
id: O13774
db: uniprot

DHFR isoform 1
type: ProteinReference
xref: uniprot H2QR61 26
organism: Pan troglodytes

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 123

serine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P9WNX1 66
type: UnificationXref
id: P9WNX1
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: uniprot P0A884 52
organism: Escherichia coli

GTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q6GKX5 4
type: UnificationXref
id: Q6GKX5
db: uniprot

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 32

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 132

Dihydrofolate synthase
type: Protein
entity reference: Dihydrofolate synthase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r14 185
type: Stoichiometry
physical entity: 5,10-methylenetetrahydrofolate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 184
type: Stoichiometry
physical entity: glycine
stoichiometric coefficient: 1.0

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q337F3 76
organism: Oryza sativa

PARTICIPANT STOICHIOMETRY r14 183
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 182
type: Stoichiometry
physical entity: serine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 181
type: Stoichiometry
physical entity: tetrahydrofolate
stoichiometric coefficient: 1.0

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P9WNX1 66
organism: Mycobacterium tuberculosis

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 135

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot Q55759 148
organism: Synechocystis

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 155

5,10-methylenetetrahydrofolate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thymidylate synthase
type: ProteinReference
xref: uniprot P12461 58
organism: Candida albicans

dihydroneopterin phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dihydroneopterin aldolase 2
type: ProteinReference
xref: uniprot Q9FM54 10
organism: Arabidopsis thaliana

uniprot Q07801 70
type: UnificationXref
id: Q07801
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 15

PARTICIPANT STOICHIOMETRY r9 193
type: Stoichiometry
physical entity: 7,8-dihydrofolate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 192
type: Stoichiometry
physical entity: 7,8-dihydropteroate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 195
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 194
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

ncbitaxon 190304 89
type: UnificationXref
id: 190304
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r9 190
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 191
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

uniprot P28822 112
type: UnificationXref
id: P28822
db: uniprot

STATE_TRANSITION_LEFT__tetrahydrofolate-_serine-RIGHT__H2O-_glycine-_5,10_methylenetetrahydrofolate-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 184
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 181
left: tetrahydrofolate
left: serine
interaction type: STATE_TRANSITION
right: H2O
right: 5,10-methylenetetrahydrofolate
right: glycine

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q9SF23 13
type: UnificationXref
id: Q9SF23
db: uniprot

Dihydrofolate synthetase
type: ProteinReference
xref: uniprot Q12676 74
organism: Saccharomyces cerevisiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_2_H2O-RIGHT__dihydroneopterin_triphosphate-_2_H2O-_formate-_r1
controller: GTP cyclohydrolase

Thymidylate synthetase
type: ProteinReference
xref: uniprot Q6P045 80
organism: Danio rerio

Folate synthesis bifunctional protein
type: ProteinReference
xref: uniprot Q1ENB6 114
organism: Arabidopsis thaliana

uniprot P53848 113
type: UnificationXref
id: P53848
db: uniprot

P02951
type: UnificationXref
id: P02951
db: PANTHER Pathway Component

5-Hydroxymethyl-7,8-dihydropteridine pyrophosphokinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot Q9SFV7 161
organism: Arabidopsis thaliana

ncbitaxon 36329 86
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot Q8F9Y0 119
type: UnificationXref
id: Q8F9Y0
db: uniprot

uniprot Q9VYL1 106
type: UnificationXref
id: Q9VYL1
db: uniprot

P02948
type: UnificationXref
id: P02948
db: PANTHER Pathway Component

P02945
type: UnificationXref
id: P02945
db: PANTHER Pathway Component

P02943
type: UnificationXref
id: P02943
db: PANTHER Pathway Component

uniprot Q9I351 159
type: UnificationXref
id: Q9I351
db: uniprot

P02941
type: UnificationXref
id: P02941
db: PANTHER Pathway Component

Dihydrofolate reductase
type: Protein
entity reference: Dihydrofolate reductase
comment: SPECIES_TYPE=PROTEIN

uniprot P0CI79 53
type: UnificationXref
id: P0CI79
db: uniprot

Folylpolyglutamate synthetase
type: ProteinReference
xref: uniprot O67833 31
organism: Aquifex aeolicus

uniprot P06785 44
type: UnificationXref
id: P06785
db: uniprot

uniprot Q1ENB6 114
type: UnificationXref
id: Q1ENB6
db: uniprot

dihydroneopterin triphosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

AGAP010278-PA
type: ProteinReference
xref: uniprot Q7Q0L5 81
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY r8 196
type: Stoichiometry
physical entity: 4-amino-4-deoxychorismate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 197
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 198
type: Stoichiometry
physical entity: p-aminobenzoate
stoichiometric coefficient: 1.0

uniprot Q8RH41 121
type: UnificationXref
id: Q8RH41
db: uniprot

uniprot P45352 62
type: UnificationXref
id: P45352
db: uniprot

ncbitaxon 272561 111
type: UnificationXref
id: 272561
db: ncbitaxon

Dihydropteroate synthase
type: ProteinReference
xref: uniprot Q8RH41 121
organism: Fusobacterium nucleatum

PARTICIPANT STOICHIOMETRY r7 199
type: Stoichiometry
physical entity: chorismate
stoichiometric coefficient: 1.0

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot Q8RH43 153
organism: Fusobacterium nucleatum

ncbitaxon 226186 9
type: UnificationXref
id: 226186
db: ncbitaxon

Thymidylate synthase
type: ProteinReference
xref: uniprot Q9N588 99
organism: Caenorhabditis elegans

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 130

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZD25 136
organism: Macaca mulatta

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot F1NEK8 134
organism: Gallus gallus

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 73

ncbitaxon 6238 130
type: UnificationXref
id: 6238
db: ncbitaxon

Dihydroneopterin aldolase 1
type: ProteinReference
xref: uniprot Q9SF23 13
organism: Arabidopsis thaliana

glutamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q7Q5H2 151
type: UnificationXref
id: Q7Q5H2
db: uniprot

uniprot Q7QDW7 83
type: UnificationXref
id: Q7QDW7
db: uniprot

Dihydropteroate synthase
type: ProteinReference
xref: P02945
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydropteroate synthase Synonym: Synonym not specified Accession: P02945
comment: ENTITY_REFERENCE_ID_DESC=Tetrahydrofolate biosynthesis.PROTEIN.GENERIC.Dihydropteroate synthase
member entity reference: Dihydropteroate synthase
member entity reference: Folate synthesis bifunctional protein
member entity reference: Folate synthesis bifunctional protein, mitochondrial
member entity reference: Folic acid synthesis protein FOL1

uniprot O74742 33
type: UnificationXref
id: O74742
db: uniprot

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 77

Probable thymidylate synthase
type: ProteinReference
xref: uniprot Q9UTI7 105
organism: Schizosaccharomyces pombe

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 95

pyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9FM54 10
type: UnificationXref
id: Q9FM54
db: uniprot

Dihydrofolate reductase
type: ProteinReference
xref: P02948
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydrofolate reductase Synonym: Synonym not specified Accession: P02948
comment: ENTITY_REFERENCE_ID_DESC=Tetrahydrofolate biosynthesis.PROTEIN.GENERIC.Dihydrofolate reductase
member entity reference: Bifunctional dihydrofolate reductase-thymidylate synthase
member entity reference: AGAP010278-PA
member entity reference: Dihydrofolate reductase
member entity reference: Thymidylate synthase
member entity reference: Thymidylate synthase ThyA
member entity reference: AGAP010457-PA
member entity reference: Uncharacterized protein
member entity reference: Putative dihydrofolate reductase
member entity reference: DHFR isoform 1
member entity reference: Thymidylate synthetase
member entity reference: Bifunctional dihydrofolate reductase-thymidylate synthase 1
member entity reference: Fibronectin 1
member entity reference: Thymidylate synthase 1
member entity reference: Dihydrofolate reductase 2, mitochondrial
member entity reference: Thymidylate synthase 2
member entity reference: Probable thymidylate synthase

Dihydropteroate synthase
type: ProteinReference
xref: uniprot Q7NN73 115
organism: Gloeobacter violaceus

PARTICIPANT STOICHIOMETRY r10 186
type: Stoichiometry
physical entity: 7,8-dihydrofolate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 188
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 187
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 189
type: Stoichiometry
physical entity: tetrahydrofolate
stoichiometric coefficient: 1.0

Dihydropteroate synthase
type: ProteinReference
xref: uniprot Q7UQ75 116
organism: Rhodopirellula baltica

Aminodeoxychorismate ligase
type: Protein
comment: SPECIES_TYPE=PROTEIN

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot P9WN57 145
organism: Mycobacterium tuberculosis

uniprot Q9X8I3 162
type: UnificationXref
id: Q9X8I3
db: uniprot

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot Q582G3 78
organism: Trypanosoma brucei

uniprot P00376 41
type: UnificationXref
id: P00376
db: uniprot

PARTICIPANT STOICHIOMETRY r7 200
type: Stoichiometry
physical entity: glutamine
stoichiometric coefficient: 1.0

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 82

uniprot O13492 29
type: UnificationXref
id: O13492
db: uniprot

PARTICIPANT STOICHIOMETRY r7 201
type: Stoichiometry
physical entity: 4-amino-4-deoxychorismate
stoichiometric coefficient: 1.0

uniprot O66603 139
type: UnificationXref
id: O66603
db: uniprot

PARTICIPANT STOICHIOMETRY r7 202
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 55

uniprot Q8A5T9 8
type: UnificationXref
id: Q8A5T9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dihydroneopterin-RIGHT__glycolaldehyde-_2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine-_r4
controller: Dihydroneopterin aldolase

chorismate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 111

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p_aminobenzoate-_2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine_diphosphate-RIGHT__PPi-_7,8_dihydropteroate-_r6
controller: Dihydropteroate synthase

uniprot P48760 64
type: UnificationXref
id: P48760
db: uniprot

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot O13492 29
organism: Neurospora crassa

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 108

uniprot Q9I6E3 96
type: UnificationXref
id: Q9I6E3
db: uniprot

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot Q19980 147
organism: Caenorhabditis elegans

ncbitaxon 178306 155
type: UnificationXref
id: 178306
db: ncbitaxon

ncbitaxon 7165 82
type: UnificationXref
id: 7165
db: ncbitaxon

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q8RES8 88
organism: Fusobacterium nucleatum

ncbitaxon 559292 45
type: UnificationXref
id: 559292
db: ncbitaxon

Glycine hydroxymethyltransferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 149

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q8W035 91
organism: Arabidopsis thaliana

ncbitaxon 83333 51
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot P36591 61
type: UnificationXref
id: P36591
db: uniprot

Folate synthesis bifunctional protein
type: ProteinReference
xref: uniprot O84619 110
organism: Chlamydia trachomatis

PANTHER Pathway P02742 1
type: UnificationXref
id: P02742
db: PANTHER Pathway

ncbitaxon 5664 47
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot Q337F3 76
type: UnificationXref
id: Q337F3
db: uniprot

uniprot P00375 39
type: UnificationXref
id: P00375
db: uniprot

ncbitaxon 208964 95
type: UnificationXref
id: 208964
db: ncbitaxon

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot Q8ZWW5 154
organism: Pyrobaculum aerophilum

Thymidylate synthase
type: ProteinReference
xref: uniprot P0CS12 54
organism: Cryptococcus neoformans

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot P19465 140
organism: Bacillus subtilis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT___chorismate-_glutamine-RIGHT__4_amino_4_deoxychorismate-_glutamate-_r7
controller: Aminodeoxychorismate synthase

ncbitaxon 10116 63
type: UnificationXref
id: 10116
db: ncbitaxon

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot Q9SIK4 103
organism: Arabidopsis thaliana

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P07807 49
organism: Saccharomyces cerevisiae

uniprot P0A884 52
type: UnificationXref
id: P0A884
db: uniprot

GTP cyclohydrolase
type: ProteinReference
xref: P02951
standard name: GTP cyclohydrolase I
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: GTP cyclohydrolase I Synonym: Synonym not specified Accession: P02951
comment: ENTITY_REFERENCE_ID_DESC=Tetrahydrofolate biosynthesis.PROTEIN.GENERIC.GTP cyclohydrolase
member entity reference: GTP cyclohydrolase 1
member entity reference: GTP cyclohydrolase 1 2
member entity reference: GTP cyclohydrolase 2
member entity reference: AGAP006441-PA
member entity reference: GTP cyclohydrolase 1 1
member entity reference: Protein CBR-CAT-4
member entity reference: Uncharacterized protein
member entity reference: GTP cyclohydrolase I
member entity reference: GCH1 isoform 1

2 H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P00374 37
type: UnificationXref
id: P00374
db: uniprot

uniprot Q9SIK4 103
type: UnificationXref
id: Q9SIK4
db: uniprot

Thymidylate synthase ThyA
type: ProteinReference
xref: uniprot P9WFR9 65
organism: Mycobacterium tuberculosis

uniprot P08192 50
type: UnificationXref
id: P08192
db: uniprot

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dihydrofolate reductase
type: ProteinReference
xref: uniprot Q9RR65 100
organism: Deinococcus radiodurans

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot F4J2K2 20
organism: Arabidopsis thaliana

Thymidylate synthase
type: ProteinReference
xref: uniprot Q9RR67 101
organism: Deinococcus radiodurans

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 9

ncbitaxon 237561 59
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot G2HEY4 24
type: UnificationXref
id: G2HEY4
db: uniprot

uniprot Q7NN73 115
type: UnificationXref
id: Q7NN73
db: uniprot

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot P30793 141
organism: Homo sapiens

Dihydrofolate synthetase
type: ProteinReference
xref: uniprot F4JYE9 21
organism: Arabidopsis thaliana

uniprot P51599 143
type: UnificationXref
id: P51599
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 34

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9SZV3 126
type: UnificationXref
id: Q9SZV3
db: uniprot

uniprot A0A1D5RHP4 16
type: UnificationXref
id: A0A1D5RHP4
db: uniprot

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P00374 37
organism: Homo sapiens

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P00375 39
organism: Mus musculus

Putative dihydrofolate reductase
type: ProteinReference
xref: uniprot Q93341 93
organism: Caenorhabditis elegans

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P00376 41
organism: Bos taurus

Dihydropteroate synthase
type: ProteinReference
xref: uniprot P28822 112
organism: Bacillus subtilis

AGAP006441-PA
type: ProteinReference
xref: uniprot Q7Q5H2 151
organism: Anopheles gambiae

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot Q8I1R6 85
organism: Plasmodium falciparum

Tetrahydrofolate biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__ATP-_glutamate-_7,8_dihydropteroate-RIGHT__7,8_dihydrofolate-_ADP-_PO4-_r9
pathway component: STATE_TRANSITION_LEFT__dihydroneopterin-RIGHT__glycolaldehyde-_2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine-_r4
pathway component: STATE_TRANSITION_LEFT__ATP-_2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine-RIGHT__2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine_diphosphate-_ADP-_r5
pathway component: STATE_TRANSITION_LEFT__4_amino_4_deoxychorismate-RIGHT__pyruvate-_p_aminobenzoate-_r8
pathway component: STATE_TRANSITION_LEFT__dihydroneopterin_triphosphate-RIGHT__PPi-_dihydroneopterin_phosphate-_r2
pathway component: STATE_TRANSITION_LEFT__dihydroneopterin_phosphate-RIGHT__PO4-_dihydroneopterin-_r3
pathway component: STATE_TRANSITION_LEFT__tetrahydrofolate-_serine-RIGHT__H2O-_glycine-_5,10_methylenetetrahydrofolate-_r14
pathway component: STATE_TRANSITION_LEFT__p_aminobenzoate-_2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine_diphosphate-RIGHT__PPi-_7,8_dihydropteroate-_r6
pathway component: STATE_TRANSITION_LEFT___chorismate-_glutamine-RIGHT__4_amino_4_deoxychorismate-_glutamate-_r7
pathway component: STATE_TRANSITION_LEFT__GTP-_2_H2O-RIGHT__dihydroneopterin_triphosphate-_2_H2O-_formate-_r1
pathway component: STATE_TRANSITION_LEFT__7,8_dihydrofolate-_NADPH-RIGHT__NADP-_tetrahydrofolate-_r10
xref: PANTHER Pathway P02742 1
comment: MODEL_NOTES= The biosynthesis of tetrahydrofolate. Tetrahydrofolate functions inside the cell as a transporter of one carbon functional groups such as methyl, methylene, and formyl groups. Website=www.biocyc.org/Ecoli/Pahthways/ free text=Voet and Voet (textbook) Biochemistry

PARTICIPANT STOICHIOMETRY r2 175
type: Stoichiometry
physical entity: dihydroneopterin phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 174
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

Dihydroneopterin aldolase
type: ProteinReference
xref: uniprot P28823 2
organism: Bacillus subtilis

PARTICIPANT STOICHIOMETRY r2 173
type: Stoichiometry
physical entity: dihydroneopterin triphosphate
stoichiometric coefficient: 1.0

uniprot Q920D2 92
type: UnificationXref
id: Q920D2
db: uniprot

ncbitaxon 9544 17
type: UnificationXref
id: 9544
db: ncbitaxon

Dihydropteroate synthase
type: Protein
entity reference: Dihydropteroate synthase
comment: SPECIES_TYPE=PROTEIN

uniprot P17719 60
type: UnificationXref
id: P17719
db: uniprot

uniprot E2RI70 131
type: UnificationXref
id: E2RI70
db: uniprot

ncbitaxon 284812 34
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q9UTD0 104
type: UnificationXref
id: Q9UTD0
db: uniprot

uniprot P11044 56
type: UnificationXref
id: P11044
db: uniprot

uniprot F6SNN4 22
type: UnificationXref
id: F6SNN4
db: uniprot

Folyl-polyglutamate synthetase
type: ProteinReference
xref: uniprot Q9RXH3 102
organism: Deinococcus radiodurans

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZRA0 23
organism: Macaca mulatta

p-aminobenzoate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__dihydroneopterin_triphosphate-RIGHT__PPi-_dihydroneopterin_phosphate-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 174
left: dihydroneopterin triphosphate
interaction type: STATE_TRANSITION
right: dihydroneopterin phosphate
right: PPi

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 120

uniprot O84619 110
type: UnificationXref
id: O84619
db: uniprot

ncbitaxon 188937 123
type: UnificationXref
id: 188937
db: ncbitaxon

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot P51601 144
organism: Saccharomyces cerevisiae

uniprot Q8RGP6 90
type: UnificationXref
id: Q8RGP6
db: uniprot

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 12

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 38

ncbitaxon 9031 135
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot P51601 144
type: UnificationXref
id: P51601
db: uniprot

uniprot Q8RES8 88
type: UnificationXref
id: Q8RES8
db: uniprot

uniprot Q05865 68
type: UnificationXref
id: Q05865
db: uniprot

ncbitaxon 83332 28
type: UnificationXref
id: 83332
db: ncbitaxon

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 5

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot O13774 138
organism: Schizosaccharomyces pombe

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P36591 61
organism: Schizosaccharomyces pombe

uniprot P12461 58
type: UnificationXref
id: P12461
db: uniprot

GTP cyclohydrolase 1 2
type: ProteinReference
xref: uniprot Q9I351 159
organism: Pseudomonas aeruginosa

GTP cyclohydrolase I
type: ProteinReference
xref: uniprot Q8I5H7 152
organism: Plasmodium falciparum

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 28

uniprot A2BGQ1 18
type: UnificationXref
id: A2BGQ1
db: uniprot

Dihydroneopterin phosphate dephosphorylase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Folate synthesis bifunctional protein, mitochondrial
type: ProteinReference
xref: uniprot Q9SZV3 126
organism: Arabidopsis thaliana

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q08645 71
organism: Saccharomyces cerevisiae

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 51

Danio rerio
type: BioSource
xref: ncbitaxon 7955 19

Putative folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q09509 72
organism: Caenorhabditis elegans

GTP cyclohydrolase 1 1
type: ProteinReference
xref: uniprot Q9HYG8 158
organism: Pseudomonas aeruginosa

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot F1MZ14 133
organism: Bos taurus

uniprot Q7Q0L5 81
type: UnificationXref
id: Q7Q0L5
db: uniprot

ncbitaxon 7955 19
type: UnificationXref
id: 7955
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r5 166
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 165
type: Stoichiometry
physical entity: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 164
type: Stoichiometry
physical entity: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 163
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot P04818 43
type: UnificationXref
id: P04818
db: uniprot

uniprot Q9L1G4 98
type: UnificationXref
id: Q9L1G4
db: uniprot

uniprot Q9RYB4 160
type: UnificationXref
id: Q9RYB4
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: uniprot Q9I6F1 97
organism: Pseudomonas aeruginosa

uniprot O67448 109
type: UnificationXref
id: O67448
db: uniprot

uniprot P48596 142
type: UnificationXref
id: P48596
db: uniprot

PARTICIPANT STOICHIOMETRY r6 203
type: Stoichiometry
physical entity: p-aminobenzoate
stoichiometric coefficient: 1.0

Dihydroneopterin triphosphate pyrophosphohydrolase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q9WXP7 127
type: UnificationXref
id: Q9WXP7
db: uniprot

PARTICIPANT STOICHIOMETRY r6 204
type: Stoichiometry
physical entity: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 205
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 206
type: Stoichiometry
physical entity: 7,8-dihydropteroate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 180
type: Stoichiometry
physical entity: formate
stoichiometric coefficient: 1.0

uniprot Q9RR65 100
type: UnificationXref
id: Q9RR65
db: uniprot

Aminodeoxychorismate synthase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q8IE69 87
type: UnificationXref
id: Q8IE69
db: uniprot

Probable folylpolyglutamate synthase
type: ProteinReference
xref: uniprot O74742 33
organism: Schizosaccharomyces pombe

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 89

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__7,8_dihydrofolate-_NADPH-RIGHT__NADP-_tetrahydrofolate-_r10
controller: Dihydrofolate reductase

glycolaldehyde
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 157

uniprot Q8W035 91
type: UnificationXref
id: Q8W035
db: uniprot

uniprot P19465 140
type: UnificationXref
id: P19465
db: uniprot

STATE_TRANSITION_LEFT__ATP-_glutamate-_7,8_dihydropteroate-RIGHT__7,8_dihydrofolate-_ADP-_PO4-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 191
left: glutamate
left: ATP
left: 7,8-dihydropteroate
interaction type: STATE_TRANSITION
right: PO4
right: 7,8-dihydrofolate
right: ADP

Protein CBR-CAT-4
type: ProteinReference
xref: uniprot A8X8K8 129
organism: Caenorhabditis briggsae

ncbitaxon 3702 5
type: UnificationXref
id: 3702
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dihydroneopterin_phosphate-RIGHT__PO4-_dihydroneopterin-_r3
controller: Dihydroneopterin phosphate dephosphorylase

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 79

uniprot Q582G3 78
type: UnificationXref
id: Q582G3
db: uniprot

ncbitaxon 251221 7
type: UnificationXref
id: 251221
db: ncbitaxon

uniprot P30793 141
type: UnificationXref
id: P30793
db: uniprot

uniprot F1MZ14 133
type: UnificationXref
id: F1MZ14
db: uniprot

7,8-dihydroneopterin aldolase
type: ProteinReference
xref: uniprot Q7NKJ0 6
organism: Gloeobacter violaceus

uniprot Q9RXH3 102
type: UnificationXref
id: Q9RXH3
db: uniprot

uniprot Q7UQ75 116
type: UnificationXref
id: Q7UQ75
db: uniprot

ncbitaxon 224308 3
type: UnificationXref
id: 224308
db: ncbitaxon

ncbitaxon 1111708 149
type: UnificationXref
id: 1111708
db: ncbitaxon

Dihydrofolate synthase/folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q05865 68
organism: Bacillus subtilis

ncbitaxon 7227 36
type: UnificationXref
id: 7227
db: ncbitaxon

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 63

Dihydrofolate reductase
type: ProteinReference
xref: uniprot Q9I6E3 96
organism: Pseudomonas aeruginosa

dihydroneopterin
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__ATP-_2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine-RIGHT__2_amino_4_hydroxy_6_hydroxymethyl_7,8_dihydropteridine_diphosphate-_ADP-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 166
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 163
left: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
left: ATP
interaction type: STATE_TRANSITION
right: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
right: ADP

ncbitaxon 214684 55
type: UnificationXref
id: 214684
db: ncbitaxon

ncbitaxon 224324 32
type: UnificationXref
id: 224324
db: ncbitaxon

ncbitaxon 44689 157
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot Q9UTI7 105
type: UnificationXref
id: Q9UTI7
db: uniprot

Dihydroneopterin aldolase
type: ProteinReference
xref: P02941
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydroneopterin aldolase Synonym: Synonym not specified Accession: P02941
comment: ENTITY_REFERENCE_ID_DESC=Tetrahydrofolate biosynthesis.PROTEIN.GENERIC.Dihydroneopterin aldolase
member entity reference: 7,8-dihydroneopterin aldolase
member entity reference: Dihydroneopterin aldolase 2
member entity reference: Probable dihydroneopterin aldolase 3
member entity reference: Dihydroneopterin aldolase 1
member entity reference: Dihydroneopterin aldolase

Dihydroneopterin aldolase
type: Protein
entity reference: Dihydroneopterin aldolase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 367110 30
type: UnificationXref
id: 367110
db: ncbitaxon

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q9VYL1 106
organism: Drosophila melanogaster

Thymidylate synthase
type: ProteinReference
xref: uniprot P45352 62
organism: Rattus norvegicus

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 117

uniprot Q9FBL7 124
type: UnificationXref
id: Q9FBL7
db: uniprot

uniprot Q08645 71
type: UnificationXref
id: Q08645
db: uniprot

Probable dihydroneopterin aldolase 3
type: ProteinReference
xref: uniprot Q6GKX5 4
organism: Arabidopsis thaliana

uniprot Q9X8I0 14
type: UnificationXref
id: Q9X8I0
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot P07382 46
type: UnificationXref
id: P07382
db: uniprot

Dihydropteroate synthase
type: ProteinReference
xref: uniprot O67448 109
organism: Aquifex aeolicus

Folylpolyglutamate synthetase
type: ProteinReference
xref: uniprot Q9HZA8 94
organism: Pseudomonas aeruginosa

ncbitaxon 9606 38
type: UnificationXref
id: 9606
db: ncbitaxon

ncbitaxon 243274 108
type: UnificationXref
id: 243274
db: ncbitaxon

Folic acid synthesis protein FOL1
type: ProteinReference
xref: uniprot P53848 113
organism: Saccharomyces cerevisiae

Candida albicans
type: BioSource
xref: ncbitaxon 237561 59

uniprot P28823 2
type: UnificationXref
id: P28823
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: uniprot P06785 44
organism: Saccharomyces cerevisiae

uniprot Q1K7T9 75
type: UnificationXref
id: Q1K7T9
db: uniprot

Folylpolyglutamate synthase, mitochondrial
type: ProteinReference
xref: uniprot P48760 64
organism: Mus musculus

Leishmania major
type: BioSource
xref: ncbitaxon 5664 47

uniprot F4J2K2 20
type: UnificationXref
id: F4J2K2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4_amino_4_deoxychorismate-RIGHT__pyruvate-_p_aminobenzoate-_r8
controller: Aminodeoxychorismate ligase

Bifunctional dihydrofolate reductase-thymidylate synthase 1
type: ProteinReference
xref: uniprot Q05762 67
organism: Arabidopsis thaliana

tetrahydrofolate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

GCH1 isoform 1
type: ProteinReference
xref: uniprot H2RBI2 137
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__tetrahydrofolate-_serine-RIGHT__H2O-_glycine-_5,10_methylenetetrahydrofolate-_r14
controller: Glycine hydroxymethyltransferase

Dihydropteroate synthase
type: ProteinReference
xref: uniprot Q8F9Y0 119
organism: Leptospira interrogans

uniprot Q8I1R6 85
type: UnificationXref
id: Q8I1R6
db: uniprot

Thymidylate synthase 1
type: ProteinReference
xref: uniprot P0CI79 53
organism: Bacillus subtilis

uniprot F1NEK8 134
type: UnificationXref
id: F1NEK8
db: uniprot

uniprot H2RBI2 137
type: UnificationXref
id: H2RBI2
db: uniprot

PARTICIPANT STOICHIOMETRY r1 179
type: Stoichiometry
physical entity: 2 H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 178
type: Stoichiometry
physical entity: dihydroneopterin triphosphate
stoichiometric coefficient: 1.0

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot E2RI70 131
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r1 176
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 177
type: Stoichiometry
physical entity: 2 H2O
stoichiometric coefficient: 1.0

GTP cyclohydrolase 1
type: ProteinReference
xref: uniprot Q9RYB4 160
organism: Deinococcus radiodurans

Fibronectin 1
type: ProteinReference
xref: uniprot G2HEY4 24
organism: Pan troglodytes

uniprot Q9WY13 107
type: UnificationXref
id: Q9WY13
db: uniprot

Dihydropteroate synthase
type: ProteinReference
xref: uniprot Q8A1L5 118
organism: Bacteroides thetaiotaomicron