uniprot Q9KGU7 44
type: UnificationXref
id: Q9KGU7
db: uniprot

Thiamin kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q38854 37
type: UnificationXref
id: Q38854
db: uniprot

5-phosphoribosyl-5-aminoimidazole
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 1111708 33
type: UnificationXref
id: 1111708
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__thiamine_phosphate-RIGHT__thiamine_pyrophosphate-_r4
controller: Thiamin phosphate kinase

4-amino-5-hydroxymethyl 2-methylpyrimidine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot Q9X291 48
organism: Thermotoga maritima

Thiamine-phosphate synthase
type: ProteinReference
xref: uniprot Q9RYX9 18
organism: Deinococcus radiodurans

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 7

4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thiamin biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__thiamine_phosphate-RIGHT__thiamine_pyrophosphate-_r4
pathway component: STATE_TRANSITION_LEFT__4_amino_5_hydroxymethyl_2_methylpyrimidine-_5_phosphoribosyl_5_aminoimidazole-_ATP-RIGHT__ADP-_4_amino_5_hydroxymethyl_2_methylpyrimidine_phosphate-_r1
pathway component: STATE_TRANSITION_LEFT__thiamine-_ATP-RIGHT__ADP-_thiamine_phosphate-_r8
pathway component: STATE_TRANSITION_LEFT__1_deoxy_D_xylulose_5_phosphate-_tyrosine-RIGHT__4_hydroxy_benzyl_alcohol-_4_methyl_5__hydroxyethyl__thiazole_phosphate-_r7
pathway component: STATE_TRANSITION_LEFT__4_methyl_5__hydroxyethyl_thiazole-_ATP-RIGHT__ADP-_4_methyl_5__hydroxyethyl__thiazole_phosphate-_r5
pathway component: STATE_TRANSITION_LEFT__4_amino_5_hydroxymethyl_2_methylpyrimidine_pyrophosphate-_4_methyl_5__hydroxyethyl__thiazole_phosphate-RIGHT__PPi-_thiamine_phosphate-_r3
pathway component: STATE_TRANSITION_LEFT__pyruvate-_glyceraldehyde_3_phosphate-RIGHT__1_deoxy_D_xylulose_5_phosphate-_r6
pathway component: STATE_TRANSITION_LEFT__ATP-_4_amino_5_hydroxymethyl_2_methylpyrimidine_phosphate-RIGHT__4_amino_5_hydroxymethyl_2_methylpyrimidine_pyrophosphate-_ADP-_r2
xref: PANTHER Pathway P02779 1
comment: MODEL_NOTES= The biosynthesis of thiamin (Vitamin B1). Thiamin is a cofactor for a small number of decarboxylating enzymes that are central to metabolism. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

glyceraldehyde-3-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P77488 34
type: UnificationXref
id: P77488
db: uniprot

ncbitaxon 36329 41
type: UnificationXref
id: 36329
db: ncbitaxon

ncbitaxon 226186 11
type: UnificationXref
id: 226186
db: ncbitaxon

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot Q8R606 42
organism: Fusobacterium nucleatum

uniprot Q8RI59 14
type: UnificationXref
id: Q8RI59
db: uniprot

uniprot Q8IDW0 40
type: UnificationXref
id: Q8IDW0
db: uniprot

ncbitaxon 39947 23
type: UnificationXref
id: 39947
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4_amino_5_hydroxymethyl_2_methylpyrimidine_pyrophosphate-_4_methyl_5__hydroxyethyl__thiazole_phosphate-RIGHT__PPi-_thiamine_phosphate-_r3
controller: Thiamin phosphate synthase

uniprot P54523 31
type: UnificationXref
id: P54523
db: uniprot

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 5

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 15

Thiamine phosphate pyrophosphorylase
type: ProteinReference
xref: uniprot Q8F4P9 12
organism: Leptospira interrogans

pyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__4_amino_5_hydroxymethyl_2_methylpyrimidine_pyrophosphate-_4_methyl_5__hydroxyethyl__thiazole_phosphate-RIGHT__PPi-_thiamine_phosphate-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 51
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 52
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 54
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 53
left: 4-amino-5-hydroxymethyl-2 methylpyrimidine-pyrophosphate
left: 4-methyl-5-(hydroxyethyl) thiazole phosphate
interaction type: STATE_TRANSITION
right: PPi
right: thiamine-phosphate

Hydroxyethyl thiazole kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__pyruvate-_glyceraldehyde_3_phosphate-RIGHT__1_deoxy_D_xylulose_5_phosphate-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 72
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 73
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 74
left: pyruvate
left: glyceraldehyde-3-phosphate
interaction type: STATE_TRANSITION
right: 1-deoxy-D-xylulose-5-phosphate

ncbitaxon 100226 21
type: UnificationXref
id: 100226
db: ncbitaxon

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 30

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 49

Thiamin phosphate kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q9S2V2 20
type: UnificationXref
id: Q9S2V2
db: uniprot

PARTICIPANT STOICHIOMETRY r3 52
type: Stoichiometry
physical entity: 4-methyl-5-(hydroxyethyl) thiazole phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 51
type: Stoichiometry
physical entity: 4-amino-5-hydroxymethyl-2 methylpyrimidine-pyrophosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 54
type: Stoichiometry
physical entity: thiamine-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 53
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

1-deoxy-D-xylulose-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_4_amino_5_hydroxymethyl_2_methylpyrimidine_phosphate-RIGHT__4_amino_5_hydroxymethyl_2_methylpyrimidine_pyrophosphate-_ADP-_r2
controller: Hydroxymethylpyrimidine phosphate kinase

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 33

ncbitaxon 3702 38
type: UnificationXref
id: 3702
db: ncbitaxon

Thiamin phosphate synthase
type: Protein
entity reference: Thiamin phosphate synthase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9LFL9 46
type: UnificationXref
id: Q9LFL9
db: uniprot

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot O81954 27
organism: Chlamydomonas reinhardtii

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 17

ncbitaxon 243274 49
type: UnificationXref
id: 243274
db: ncbitaxon

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot P73067 32
organism: Synechocystis

Os06g0142900 protein
type: ProteinReference
xref: uniprot A0A0P0WSV0 22
organism: Oryza sativa

uniprot P73067 32
type: UnificationXref
id: P73067
db: uniprot

ncbitaxon 3055 28
type: UnificationXref
id: 3055
db: ncbitaxon

Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)
type: ProteinReference
xref: uniprot O50408 24
organism: Mycobacterium tuberculosis

uniprot P9WNS3 36
type: UnificationXref
id: P9WNS3
db: uniprot

Thiamine-phosphate synthase
type: ProteinReference
xref: uniprot Q7UQH1 8
organism: Rhodopirellula baltica

1-Deoxyxylulose-5-phosphate synthase
type: Protein
entity reference: 1-Deoxyxylulose-5-phosphate synthase
comment: SPECIES_TYPE=PROTEIN

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 3

ncbitaxon 190304 15
type: UnificationXref
id: 190304
db: ncbitaxon

uniprot O81954 27
type: UnificationXref
id: O81954
db: uniprot

uniprot O84335 29
type: UnificationXref
id: O84335
db: uniprot

STATE_TRANSITION_LEFT__ATP-_4_amino_5_hydroxymethyl_2_methylpyrimidine_phosphate-RIGHT__4_amino_5_hydroxymethyl_2_methylpyrimidine_pyrophosphate-_ADP-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 56
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 58
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 55
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 57
left: 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate
left: ATP
interaction type: STATE_TRANSITION
right: 4-amino-5-hydroxymethyl-2 methylpyrimidine-pyrophosphate
right: ADP

ncbitaxon 243230 19
type: UnificationXref
id: 243230
db: ncbitaxon

1-deoxy-D-xylulose-5-phosphate synthase 1
type: ProteinReference
xref: uniprot Q9X7W3 50
organism: Streptomyces coelicolor

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 41

Thiamin phosphate synthase
type: ProteinReference
xref: P03173
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Thiamin biosynthesis.PROTEIN.GENERIC.Thiamin phosphate_br_synthase
comment: ENTITY_REFERENCE_NOTES= Long Name: Thiamin phosphate synthase Synonym: Synonym not specified Accession: P03173
member entity reference: Thiamine phosphate pyrophosphorylase
member entity reference: Thiamine-phosphate synthase
member entity reference: Thiamine-phosphate synthase 1

Thiamine-phosphate synthase
type: ProteinReference
xref: uniprot Q9S2V2 20
organism: Streptomyces coelicolor

uniprot Q9X7W3 50
type: UnificationXref
id: Q9X7W3
db: uniprot

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot Q8R639 43
organism: Fusobacterium nucleatum

ncbitaxon 189518 13
type: UnificationXref
id: 189518
db: ncbitaxon

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 11

P03173
type: UnificationXref
id: P03173
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r5 78
type: Stoichiometry
physical entity: 4-methyl-5-(hydroxyethyl) thiazole phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 77
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 76
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Thiamine-phosphate synthase
type: ProteinReference
xref: uniprot Q8RI59 14
organism: Fusobacterium nucleatum

PARTICIPANT STOICHIOMETRY r5 75
type: Stoichiometry
physical entity: 4-methyl-5-(hydroxyethyl)thiazole
stoichiometric coefficient: 1.0

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot Q9KGU7 44
organism: Pseudomonas aeruginosa

uniprot Q8CJP7 39
type: UnificationXref
id: Q8CJP7
db: uniprot

Thiamine-phosphate synthase
type: ProteinReference
xref: uniprot Q8TMD6 16
organism: Methanosarcina acetivorans

P03175
type: UnificationXref
id: P03175
db: PANTHER Pathway Component

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot O84335 29
organism: Chlamydia trachomatis

ncbitaxon 272561 30
type: UnificationXref
id: 272561
db: ncbitaxon

Thiamine-phosphate synthase
type: ProteinReference
xref: uniprot Q8AA13 10
organism: Bacteroides thetaiotaomicron

uniprot O66833 2
type: UnificationXref
id: O66833
db: uniprot

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 9

thiamine-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 21

Thiamine-phosphate synthase 1
type: ProteinReference
xref: uniprot O66833 2
organism: Aquifex aeolicus

tyrosine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8TMD6 16
type: UnificationXref
id: Q8TMD6
db: uniprot

ncbitaxon 224308 5
type: UnificationXref
id: 224308
db: ncbitaxon

thiamine pyrophosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot P77488 34
organism: Escherichia coli

ncbitaxon 188937 17
type: UnificationXref
id: 188937
db: ncbitaxon

ncbitaxon 243090 9
type: UnificationXref
id: 243090
db: ncbitaxon

1-deoxy-D-xylulose 5-phosphate synthase
type: ProteinReference
xref: uniprot Q8IDW0 40
organism: Plasmodium falciparum

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

1-D-deoxyxylulose 5-phosphate synthase-like protein
type: ProteinReference
xref: uniprot Q9LFL9 46
organism: Arabidopsis thaliana

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4_methyl_5__hydroxyethyl_thiazole-_ATP-RIGHT__ADP-_4_methyl_5__hydroxyethyl__thiazole_phosphate-_r5
controller: Hydroxyethyl thiazole kinase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__pyruvate-_glyceraldehyde_3_phosphate-RIGHT__1_deoxy_D_xylulose_5_phosphate-_r6
controller: 1-Deoxyxylulose-5-phosphate synthase

PANTHER Pathway P02779 1
type: UnificationXref
id: P02779
db: PANTHER Pathway

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 28

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4_amino_5_hydroxymethyl_2_methylpyrimidine-_5_phosphoribosyl_5_aminoimidazole-_ATP-RIGHT__ADP-_4_amino_5_hydroxymethyl_2_methylpyrimidine_phosphate-_r1
controller: Hydroxymethylpyrimidine kinase

Hydroxymethylpyrimidine kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q8F4P9 12
type: UnificationXref
id: Q8F4P9
db: uniprot

Thiamine-phosphate synthase
type: ProteinReference
xref: uniprot Q7NNK8 6
organism: Gloeobacter violaceus

ncbitaxon 83333 35
type: UnificationXref
id: 83333
db: ncbitaxon

STATE_TRANSITION_LEFT__thiamine-_ATP-RIGHT__ADP-_thiamine_phosphate-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 64
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 67
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 66
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 65
left: thiamine
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: thiamine-phosphate

STATE_TRANSITION_LEFT__4_methyl_5__hydroxyethyl_thiazole-_ATP-RIGHT__ADP-_4_methyl_5__hydroxyethyl__thiazole_phosphate-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 78
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 76
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 77
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 75
left: ATP
left: 4-methyl-5-(hydroxyethyl)thiazole
interaction type: STATE_TRANSITION
right: ADP
right: 4-methyl-5-(hydroxyethyl) thiazole phosphate

PARTICIPANT STOICHIOMETRY r1 59
type: Stoichiometry
physical entity: 4-amino-5-hydroxymethyl 2-methylpyrimidine
stoichiometric coefficient: 1.0

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 13

ncbitaxon 83332 25
type: UnificationXref
id: 83332
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r6 74
type: Stoichiometry
physical entity: 1-deoxy-D-xylulose-5-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 73
type: Stoichiometry
physical entity: glyceraldehyde-3-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 72
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__1_deoxy_D_xylulose_5_phosphate-_tyrosine-RIGHT__4_hydroxy_benzyl_alcohol-_4_methyl_5__hydroxyethyl__thiazole_phosphate-_r7
controller: 4-Methyl-5-(hydroxyethyl)-thiazole phosphate synthase

uniprot Q9X291 48
type: UnificationXref
id: Q9X291
db: uniprot

ncbitaxon 208964 45
type: UnificationXref
id: 208964
db: ncbitaxon

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 19

thiamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RUB5 47
type: UnificationXref
id: Q9RUB5
db: uniprot

STATE_TRANSITION_LEFT__4_amino_5_hydroxymethyl_2_methylpyrimidine-_5_phosphoribosyl_5_aminoimidazole-_ATP-RIGHT__ADP-_4_amino_5_hydroxymethyl_2_methylpyrimidine_phosphate-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 63
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 62
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 59
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 61
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 60
left: 5-phosphoribosyl-5-aminoimidazole
left: ATP
left: 4-amino-5-hydroxymethyl 2-methylpyrimidine
interaction type: STATE_TRANSITION
right: ADP
right: 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate

uniprot Q9RYX9 18
type: UnificationXref
id: Q9RYX9
db: uniprot

PARTICIPANT STOICHIOMETRY r7 69
type: Stoichiometry
physical entity: tyrosine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 68
type: Stoichiometry
physical entity: 1-deoxy-D-xylulose-5-phosphate
stoichiometric coefficient: 1.0

ncbitaxon 224324 3
type: UnificationXref
id: 224324
db: ncbitaxon

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot Q9RUB5 47
organism: Deinococcus radiodurans

uniprot P39594 4
type: UnificationXref
id: P39594
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 38

4-methyl-5-(hydroxyethyl)thiazole
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__thiamine_phosphate-RIGHT__thiamine_pyrophosphate-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 79
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 80
left: thiamine-phosphate
interaction type: STATE_TRANSITION
right: thiamine pyrophosphate

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot P54523 31
organism: Bacillus subtilis

uniprot Q7UQH1 8
type: UnificationXref
id: Q7UQH1
db: uniprot

PARTICIPANT STOICHIOMETRY r8 67
type: Stoichiometry
physical entity: thiamine-phosphate
stoichiometric coefficient: 1.0

uniprot Q8R606 42
type: UnificationXref
id: Q8R606
db: uniprot

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot P9WNS3 36
organism: Mycobacterium tuberculosis

uniprot Q8AA13 10
type: UnificationXref
id: Q8AA13
db: uniprot

PARTICIPANT STOICHIOMETRY r7 71
type: Stoichiometry
physical entity: 4-methyl-5-(hydroxyethyl) thiazole phosphate
stoichiometric coefficient: 1.0

Hydroxymethylpyrimidine phosphate kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r7 70
type: Stoichiometry
physical entity: 4-hydroxy-benzyl alcohol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 62
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 63
type: Stoichiometry
physical entity: 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate
stoichiometric coefficient: 1.0

1-Deoxyxylulose-5-phosphate synthase
type: ProteinReference
xref: P03175
comment: ENTITY_REFERENCE_ID_DESC=Thiamin biosynthesis.PROTEIN.GENERIC.1-Deoxyxylulose-5-_br_phosphate synthase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: 1-Deoxyxylulose-5-phosphate synthase Synonym: Synonym not specified Accession: P03175
member entity reference: 1-deoxy-D-xylulose-5-phosphate synthase
member entity reference: Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)
member entity reference: 1-deoxy-D-xylulose 5-phosphate synthase
member entity reference: Os06g0142900 protein
member entity reference: 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
member entity reference: 1-deoxy-D-xylulose-5-phosphate synthase 2
member entity reference: 1-D-deoxyxylulose 5-phosphate synthase-like protein
member entity reference: 1-deoxy-D-xylulose-5-phosphate synthase 1

1-deoxy-D-xylulose-5-phosphate synthase 2
type: ProteinReference
xref: uniprot Q8CJP7 39
organism: Streptomyces coelicolor

uniprot Q7NNK8 6
type: UnificationXref
id: Q7NNK8
db: uniprot

PARTICIPANT STOICHIOMETRY r1 60
type: Stoichiometry
physical entity: 5-phosphoribosyl-5-aminoimidazole
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 61
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__thiamine-_ATP-RIGHT__ADP-_thiamine_phosphate-_r8
controller: Thiamin kinase

4-Methyl-5-(hydroxyethyl)-thiazole phosphate synthase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 25

1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
type: ProteinReference
xref: uniprot Q38854 37
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r4 79
type: Stoichiometry
physical entity: thiamine-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 65
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 66
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q8R639 43
type: UnificationXref
id: Q8R639
db: uniprot

PARTICIPANT STOICHIOMETRY r8 64
type: Stoichiometry
physical entity: thiamine
stoichiometric coefficient: 1.0

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 35

Thiamine-phosphate synthase
type: ProteinReference
xref: uniprot P39594 4
organism: Bacillus subtilis

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot O67036 26
organism: Aquifex aeolicus

ncbitaxon 251221 7
type: UnificationXref
id: 251221
db: ncbitaxon

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 23

PARTICIPANT STOICHIOMETRY r2 55
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

4-methyl-5-(hydroxyethyl) thiazole phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r2 56
type: Stoichiometry
physical entity: 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate
stoichiometric coefficient: 1.0

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 45

PARTICIPANT STOICHIOMETRY r2 57
type: Stoichiometry
physical entity: 4-amino-5-hydroxymethyl-2 methylpyrimidine-pyrophosphate
stoichiometric coefficient: 1.0

uniprot O50408 24
type: UnificationXref
id: O50408
db: uniprot

PARTICIPANT STOICHIOMETRY r2 58
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 80
type: Stoichiometry
physical entity: thiamine pyrophosphate
stoichiometric coefficient: 1.0

4-hydroxy-benzyl alcohol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A0P0WSV0 22
type: UnificationXref
id: A0A0P0WSV0
db: uniprot

STATE_TRANSITION_LEFT__1_deoxy_D_xylulose_5_phosphate-_tyrosine-RIGHT__4_hydroxy_benzyl_alcohol-_4_methyl_5__hydroxyethyl__thiazole_phosphate-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 70
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 68
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 69
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 71
left: tyrosine
left: 1-deoxy-D-xylulose-5-phosphate
interaction type: STATE_TRANSITION
right: 4-hydroxy-benzyl alcohol
right: 4-methyl-5-(hydroxyethyl) thiazole phosphate

4-amino-5-hydroxymethyl-2 methylpyrimidine-pyrophosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O67036 26
type: UnificationXref
id: O67036
db: uniprot