STATE_TRANSITION_LEFT__Thiamine-RIGHT__4_Amino_5_hydroxymethyl_2_methylpyrimidine-_r173
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r173 48
participant stoichiometry: PARTICIPANT STOICHIOMETRY r173 47
left: Thiamine
interaction type: STATE_TRANSITION
right: 4-Amino-5-hydroxymethyl-2-methylpyrimidine

Thiamine diphosphate kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Thiaminealdehyde
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thiamin pyrophosphokinase 1
type: ProteinReference
xref: uniprot Q9H3S4 8
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine_diphosphate-RIGHT__Thiamine_triphosphate-_r167
controller: Thiamine diphosphate kinase

Thiamine triphosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r170 51
type: Stoichiometry
physical entity: Thiamine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Thiamine-RIGHT__Thiaminealdehyde-_r163
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r163 42
participant stoichiometry: PARTICIPANT STOICHIOMETRY r163 41
left: Thiamine
interaction type: STATE_TRANSITION
right: Thiaminealdehyde

Thiamine-triphosphatase
type: ProteinReference
xref: uniprot Q8JZL3 18
xref: PTHR14586:SF1
organism: Mus musculus

KNOWN_TRANSITION_OMITTED_LEFT__1__5_QUOTE_SINGLE_Phosphoribosyl__5_aminoimidazole__AIR_-RIGHT__4_Amino_5_hydroxymethyl_2_methylpyrimidine-_r152
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r152 28
participant stoichiometry: PARTICIPANT STOICHIOMETRY r152 27
left: 1-(5'-Phosphoribosyl)-5-aminoimidazole (AIR)
interaction type: KNOWN_TRANSITION_OMITTED
right: 4-Amino-5-hydroxymethyl-2-methylpyrimidine

dITP/XTP pyrophosphatase
type: ProteinReference
xref: uniprot Q8ZVB5 10
xref: PTHR11067:SF9
organism: Pyrobaculum aerophilum

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine-RIGHT__4_Amino_5_hydroxymethyl_2_methylpyrimidine-_r173
controller: Thiaminase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine-RIGHT__Thiamine_phosphate-_r168
controller: Thiamine kinase

eco ECO:0000501 12
type: UnificationXref
id: ECO:0000501
db: eco

Thiamine pyrophosphokinase
type: ProteinReference
xref: PTHR13622:SF8
xref: uniprot P35202 2
organism: Saccharomyces cerevisiae

STATE_TRANSITION_LEFT__4_Amino_5_hydroxymethyl_2_methylpyrimidine-RIGHT__4_Amino_2_methyl_5_phosphomethylpyrimidine-_r153
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r153 26
participant stoichiometry: PARTICIPANT STOICHIOMETRY r153 25
left: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
interaction type: STATE_TRANSITION
right: 4-Amino-2-methyl-5-phosphomethylpyrimidine

Thiamine-triphosphatase
type: ProteinReference
xref: uniprot Q8MKF1 20
xref: PTHR14586:SF1
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine-RIGHT__Thiaminealdehyde-_r163
controller: Thiamine oxidase

Thiamine oxidase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3SUM8 13
type: UnificationXref
id: A0A2I3SUM8
db: uniprot

Thiamine phosphate diphosphorylase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Glyceraldehyde-3P
type: SmallMolecule
cellular location: Glycolysis c9
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r152 27
type: Stoichiometry
physical entity: 1-(5'-Phosphoribosyl)-5-aminoimidazole (AIR)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r160 46
type: Stoichiometry
physical entity: Thiamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r152 28
type: Stoichiometry
physical entity: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r160 45
type: Stoichiometry
physical entity: Thiamine phosphate
stoichiometric coefficient: 1.0

ncbitaxon 10090 19
type: UnificationXref
id: 10090
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine-RIGHT__5__2_Hydroxyethyl__4_methylthiazole-_r170
controller: Thiamine pyridinylase

PARTICIPANT STOICHIOMETRY r163 42
type: Stoichiometry
physical entity: Thiaminealdehyde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r163 41
type: Stoichiometry
physical entity: Thiamine
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine-RIGHT__Heteropyrithiamine-_r162
controller: Thiamine pyridinylase

Bos taurus
type: BioSource
xref: ncbitaxon 9913 21

PTHR11067:SF9
type: RelationshipXref
id: PTHR11067:SF9
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiaminealdehyde-RIGHT__Thiamine_acetic_acid-_r164
controller: Thiamine oxidase

Hydroxymethyl pyrimidine kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Heteropyrithiamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Mus musculus
type: BioSource
xref: ncbitaxon 10090 19

By Homology
type: RelationshipTypeVocabulary

uniprot Q9H3S4 8
type: UnificationXref
id: Q9H3S4
db: uniprot

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 12

Thiamine kinase
type: Protein
entity reference: Thiamine kinase
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4_Amino_2_methyl_5_phosphomethylpyrimidine-RIGHT__2_Methyl_4_amino_5_hydroxymethylpyrimidine_diphosphate-_r154
controller: Phosphomethyl pyrimidine kinase

STATE_TRANSITION_LEFT__Thiamine_phosphate-RIGHT__Thiamine-_r160
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r160 45
participant stoichiometry: PARTICIPANT STOICHIOMETRY r160 46
left: Thiamine phosphate
interaction type: STATE_TRANSITION
right: Thiamine

uniprot Q8ZVB5 10
type: UnificationXref
id: Q8ZVB5
db: uniprot

Thiamine acetic acid
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thiamine metabolism
type: Pathway
pathway component: STATE_TRANSITION_LEFT__2_Methyl_4_amino_5_hydroxymethylpyrimidine_diphosphate-_4_Methyl_5__2_phosphoethyl__thiazole-RIGHT__Thiamine_phosphate-_r155
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__1__5_QUOTE_SINGLE_Phosphoribosyl__5_aminoimidazole__AIR_-RIGHT__4_Amino_5_hydroxymethyl_2_methylpyrimidine-_r152
pathway component: STATE_TRANSITION_LEFT__Thiamine_diphosphate-RIGHT__Thiamine_triphosphate-_r167
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Glyceraldehyde_3P-RIGHT__5__2_Hydroxyethyl__4_methylthiazole-_r165
pathway component: STATE_TRANSITION_LEFT__Thiamine_phosphate-RIGHT__Thiamine_diphosphate-_r157
pathway component: STATE_TRANSITION_LEFT__Thiamine-RIGHT__4_Amino_5_hydroxymethyl_2_methylpyrimidine-_r173
pathway component: STATE_TRANSITION_LEFT__Thiaminealdehyde-RIGHT__Thiamine_acetic_acid-_r164
pathway component: STATE_TRANSITION_LEFT__Thiamine-RIGHT__Thiamine_phosphate-_r168
pathway component: STATE_TRANSITION_LEFT__Thiamine_triphosphate-RIGHT__Thiamine_diphosphate-_r159
pathway component: STATE_TRANSITION_LEFT__Thiamine-RIGHT__5__2_Hydroxyethyl__4_methylthiazole-_r170
pathway component: STATE_TRANSITION_LEFT__5__2_Hydroxyethyl__4_methylthiazole-RIGHT__4_Methyl_5__2_phosphoethyl__thiazole-_r156
pathway component: STATE_TRANSITION_LEFT__Thiamine-RIGHT__Heteropyrithiamine-_r162
pathway component: STATE_TRANSITION_LEFT__Thiamine-RIGHT__5__2_Hydroxyethyl__4_methylthiazole-_r171
pathway component: STATE_TRANSITION_LEFT__4_Amino_5_hydroxymethyl_2_methylpyrimidine-RIGHT__4_Amino_2_methyl_5_phosphomethylpyrimidine-_r153
pathway component: STATE_TRANSITION_LEFT__Thiamine_diphosphate-RIGHT__Thiamine_phosphate-_r158
pathway component: STATE_TRANSITION_LEFT__4_Amino_2_methyl_5_phosphomethylpyrimidine-RIGHT__2_Methyl_4_amino_5_hydroxymethylpyrimidine_diphosphate-_r154
pathway component: STATE_TRANSITION_LEFT__Thiamine-RIGHT__Thiamine_diphosphate-_r169
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Pyruvate-RIGHT__5__2_Hydroxyethyl__4_methylthiazole-_r166
pathway component: STATE_TRANSITION_LEFT__Thiamine-RIGHT__Thiaminealdehyde-_r163
pathway component: STATE_TRANSITION_LEFT__Thiamine_phosphate-RIGHT__Thiamine-_r160
xref: PANTHER Pathway P02780 1
comment: MODEL_NOTES= Boversion of vitamin B1, thiamin, into its coenzyme merely requires the addition of pyrophosphate to the thiamine, at the expense of ATP, by a pyrophosphate transferase. Website=KEGG - Kyoto Encyclopedia of Genes and Genomes http://www.genome.jp/kegg/ free text=Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal free text=Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm free text=Human Metabolism by Ramsey Bronk

ncbitaxon 9913 21
type: UnificationXref
id: 9913
db: ncbitaxon

2-Methyl-4-amino 5-hydroxymethylpyrimidine diphosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 3

Glycolysis c9
type: CellularLocationVocabulary
comment: Glycolysis

STATE_TRANSITION_LEFT__4_Amino_2_methyl_5_phosphomethylpyrimidine-RIGHT__2_Methyl_4_amino_5_hydroxymethylpyrimidine_diphosphate-_r154
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r154 23
participant stoichiometry: PARTICIPANT STOICHIOMETRY r154 24
left: 4-Amino-2-methyl-5-phosphomethylpyrimidine
interaction type: STATE_TRANSITION
right: 2-Methyl-4-amino 5-hydroxymethylpyrimidine diphosphate

ncbitaxon 284812 7
type: UnificationXref
id: 284812
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine_diphosphate-RIGHT__Thiamine_phosphate-_r158
controller: Nucleoside triphosphatase

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 15

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine-RIGHT__5__2_Hydroxyethyl__4_methylthiazole-_r171
controller: Thiaminase

ncbitaxon 9606 9
type: UnificationXref
id: 9606
db: ncbitaxon

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 17

PARTICIPANT STOICHIOMETRY r164 39
type: Stoichiometry
physical entity: Thiaminealdehyde
stoichiometric coefficient: 1.0

Thiamine pyrophosphokinase
type: ProteinReference
xref: PTHR13622:SF8
xref: uniprot P41888 6
organism: Schizosaccharomyces pombe

STATE_TRANSITION_LEFT__Thiamine_diphosphate-RIGHT__Thiamine_triphosphate-_r167
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r167 33
participant stoichiometry: PARTICIPANT STOICHIOMETRY r167 34
left: Thiamine diphosphate
interaction type: STATE_TRANSITION
right: Thiamine triphosphate

Thiaminase
type: Protein
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 178306 11
type: UnificationXref
id: 178306
db: ncbitaxon

Thiamine phosphate kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Thiamine triphosphatase
type: Protein
entity reference: Thiamine triphosphatase
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__5__2_Hydroxyethyl__4_methylthiazole-RIGHT__4_Methyl_5__2_phosphoethyl__thiazole-_r156
controller: Hydroxyethyl thiazole kinase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine_phosphate-RIGHT__Thiamine_diphosphate-_r157
controller: Thiamine phosphate kinase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2_Methyl_4_amino_5_hydroxymethylpyrimidine_diphosphate-_4_Methyl_5__2_phosphoethyl__thiazole-RIGHT__Thiamine_phosphate-_r155
controller: Thiamine phosphate diphosphorylase

STATE_TRANSITION_LEFT__Thiamine_triphosphate-RIGHT__Thiamine_diphosphate-_r159
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r159 53
participant stoichiometry: PARTICIPANT STOICHIOMETRY r159 54
left: Thiamine triphosphate
interaction type: STATE_TRANSITION
right: Thiamine diphosphate

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine-RIGHT__Thiamine_diphosphate-_r169
controller: Thiamine diphosphate kinase

PARTICIPANT STOICHIOMETRY r173 47
type: Stoichiometry
physical entity: Thiamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r164 40
type: Stoichiometry
physical entity: Thiamine acetic acid
stoichiometric coefficient: 1.0

4-Methyl 5-(2-phosphoethyl)-thiazole
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__Thiamine_diphosphate-RIGHT__Thiamine_phosphate-_r158
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r158 56
participant stoichiometry: PARTICIPANT STOICHIOMETRY r158 55
left: Thiamine diphosphate
interaction type: STATE_TRANSITION
right: Thiamine phosphate

PARTICIPANT STOICHIOMETRY r173 48
type: Stoichiometry
physical entity: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
stoichiometric coefficient: 1.0

P03176
type: UnificationXref
id: P03176
db: PANTHER Pathway Component

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 11

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 7

KNOWN_TRANSITION_OMITTED_LEFT__Glyceraldehyde_3P-RIGHT__5__2_Hydroxyethyl__4_methylthiazole-_r165
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r165 37
participant stoichiometry: PARTICIPANT STOICHIOMETRY r165 38
left: Glyceraldehyde-3P
interaction type: KNOWN_TRANSITION_OMITTED
right: 5-(2-Hydroxyethyl)-4-methylthiazole

uniprot Q8MKF1 20
type: UnificationXref
id: Q8MKF1
db: uniprot

P03180
type: UnificationXref
id: P03180
db: PANTHER Pathway Component

Nucleoside triphosphatase
type: ProteinReference
xref: P03180
comment: ENTITY_REFERENCE_NOTES= Long Name: Nucleoside triphosphatase Synonym: Synonym not specified Accession: P03180
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Thiamine metabolism.PROTEIN.GENERIC.Nucleoside_br_triphosphatase
member entity reference: dITP/XTP pyrophosphatase

P03184
type: UnificationXref
id: P03184
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Thiamine_phosphate-RIGHT__Thiamine_diphosphate-_r157
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r157 58
participant stoichiometry: PARTICIPANT STOICHIOMETRY r157 57
left: Thiamine phosphate
interaction type: STATE_TRANSITION
right: Thiamine diphosphate

STATE_TRANSITION_LEFT__Thiamine-RIGHT__Thiamine_diphosphate-_r169
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r169 30
participant stoichiometry: PARTICIPANT STOICHIOMETRY r169 29
left: Thiamine
interaction type: STATE_TRANSITION
right: Thiamine diphosphate

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 14

Thiamine-triphosphatase
type: ProteinReference
xref: uniprot Q8CGV7 16
xref: PTHR14586:SF1
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r156 59
type: Stoichiometry
physical entity: 5-(2-Hydroxyethyl)-4-methylthiazole
stoichiometric coefficient: 1.0

ncbitaxon 559292 3
type: UnificationXref
id: 559292
db: ncbitaxon

STATE_TRANSITION_LEFT__5__2_Hydroxyethyl__4_methylthiazole-RIGHT__4_Methyl_5__2_phosphoethyl__thiazole-_r156
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r156 60
participant stoichiometry: PARTICIPANT STOICHIOMETRY r156 59
left: 5-(2-Hydroxyethyl)-4-methylthiazole
interaction type: STATE_TRANSITION
right: 4-Methyl 5-(2-phosphoethyl)-thiazole

Pyruvate
type: SmallMolecule
cellular location: Glycolysis c9
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION
type: InteractionVocabulary

STATE_TRANSITION
type: RelationshipTypeVocabulary

PTHR14586:SF1
type: RelationshipXref
id: PTHR14586:SF1
db: PANTHER Family
relationship type: By Homology

Thiamine-triphosphatase
type: ProteinReference
xref: uniprot Q9BU02 22
xref: PTHR14586:SF1
organism: Homo sapiens

ncbitaxon 10116 17
type: UnificationXref
id: 10116
db: ncbitaxon

ncbitaxon 9598 14
type: UnificationXref
id: 9598
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r166 36
type: Stoichiometry
physical entity: 5-(2-Hydroxyethyl)-4-methylthiazole
stoichiometric coefficient: 1.0

uniprot P35202 2
type: UnificationXref
id: P35202
db: uniprot

Thiamine-triphosphatase
type: ProteinReference
xref: PTHR14586:SF1
xref: uniprot A0A2I3SUM8 13
organism: Pan troglodytes

STATE_TRANSITION_LEFT__Thiamine-RIGHT__Heteropyrithiamine-_r162
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r162 44
participant stoichiometry: PARTICIPANT STOICHIOMETRY r162 43
left: Thiamine
interaction type: STATE_TRANSITION
right: Heteropyrithiamine

PARTICIPANT STOICHIOMETRY r166 35
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r159 53
type: Stoichiometry
physical entity: Thiamine triphosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r159 54
type: Stoichiometry
physical entity: Thiamine diphosphate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Thiaminealdehyde-RIGHT__Thiamine_acetic_acid-_r164
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r164 40
participant stoichiometry: PARTICIPANT STOICHIOMETRY r164 39
left: Thiaminealdehyde
interaction type: STATE_TRANSITION
right: Thiamine acetic acid

KNOWN_TRANSITION_OMITTED_LEFT__Pyruvate-RIGHT__5__2_Hydroxyethyl__4_methylthiazole-_r166
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r166 35
participant stoichiometry: PARTICIPANT STOICHIOMETRY r166 36
left: Pyruvate
interaction type: KNOWN_TRANSITION_OMITTED
right: 5-(2-Hydroxyethyl)-4-methylthiazole

PARTICIPANT STOICHIOMETRY r168 31
type: Stoichiometry
physical entity: Thiamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r168 32
type: Stoichiometry
physical entity: Thiamine phosphate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__2_Methyl_4_amino_5_hydroxymethylpyrimidine_diphosphate-_4_Methyl_5__2_phosphoethyl__thiazole-RIGHT__Thiamine_phosphate-_r155
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r155 61
participant stoichiometry: PARTICIPANT STOICHIOMETRY r155 63
participant stoichiometry: PARTICIPANT STOICHIOMETRY r155 62
left: 4-Methyl 5-(2-phosphoethyl)-thiazole
left: 2-Methyl-4-amino 5-hydroxymethylpyrimidine diphosphate
interaction type: STATE_TRANSITION
right: Thiamine phosphate

PANTHER Pathway P02780 1
type: UnificationXref
id: P02780
db: PANTHER Pathway

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4_Amino_5_hydroxymethyl_2_methylpyrimidine-RIGHT__4_Amino_2_methyl_5_phosphomethylpyrimidine-_r153
controller: Hydroxymethyl pyrimidine kinase

STATE_TRANSITION_LEFT__Thiamine-RIGHT__Thiamine_phosphate-_r168
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r168 31
participant stoichiometry: PARTICIPANT STOICHIOMETRY r168 32
left: Thiamine
interaction type: STATE_TRANSITION
right: Thiamine phosphate

1-(5'-Phosphoribosyl)-5-aminoimidazole (AIR)
type: SmallMolecule
cellular location: Purine metabolism c8
comment: SPECIES_TYPE=SIMPLE_MOLECULE

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

PTHR13622:SF8
type: RelationshipXref
id: PTHR13622:SF8
db: PANTHER Family
relationship type: By Homology

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 9

PARTICIPANT STOICHIOMETRY r153 26
type: Stoichiometry
physical entity: 4-Amino-2-methyl-5-phosphomethylpyrimidine
stoichiometric coefficient: 1.0

Phosphomethyl pyrimidine kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r153 25
type: Stoichiometry
physical entity: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r154 24
type: Stoichiometry
physical entity: 2-Methyl-4-amino 5-hydroxymethylpyrimidine diphosphate
stoichiometric coefficient: 1.0

Purine metabolism c8
type: CellularLocationVocabulary
comment: Purine metabolism

uniprot Q9BU02 22
type: UnificationXref
id: Q9BU02
db: uniprot

PARTICIPANT STOICHIOMETRY r154 23
type: Stoichiometry
physical entity: 4-Amino-2-methyl-5-phosphomethylpyrimidine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r170 52
type: Stoichiometry
physical entity: 5-(2-Hydroxyethyl)-4-methylthiazole
stoichiometric coefficient: 1.0

5-(2-Hydroxyethyl)-4-methylthiazole
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thiamine kinase
type: ProteinReference
xref: P03176
comment: ENTITY_REFERENCE_NOTES= Long Name: Thiamine kinase Synonym: Synonym not specified Accession: P03176
comment: ENTITY_REFERENCE_ID_DESC=Thiamine metabolism.PROTEIN.GENERIC.Thiamine_br_kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Thiamine pyrophosphokinase
member entity reference: Thiamin pyrophosphokinase 1

4-Amino-2-methyl-5-phosphomethylpyrimidine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Nucleoside triphosphatase
type: Protein
entity reference: Nucleoside triphosphatase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r162 44
type: Stoichiometry
physical entity: Heteropyrithiamine
stoichiometric coefficient: 1.0

uniprot Q8JZL3 18
type: UnificationXref
id: Q8JZL3
db: uniprot

IDA
type: EvidenceCodeVocabulary

Thiamine diphosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thiamine pyridinylase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Hydroxyethyl thiazole kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q8CGV7 16
type: UnificationXref
id: Q8CGV7
db: uniprot

PARTICIPANT STOICHIOMETRY r165 38
type: Stoichiometry
physical entity: 5-(2-Hydroxyethyl)-4-methylthiazole
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r165 37
type: Stoichiometry
physical entity: Glyceraldehyde-3P
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r169 29
type: Stoichiometry
physical entity: Thiamine
stoichiometric coefficient: 1.0

Thiamine phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

4-Amino-5-hydroxymethyl-2-methylpyrimidine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thiamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r155 61
type: Stoichiometry
physical entity: 2-Methyl-4-amino 5-hydroxymethylpyrimidine diphosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r155 62
type: Stoichiometry
physical entity: 4-Methyl 5-(2-phosphoethyl)-thiazole
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r155 63
type: Stoichiometry
physical entity: Thiamine phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r167 33
type: Stoichiometry
physical entity: Thiamine diphosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r171 49
type: Stoichiometry
physical entity: Thiamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r162 43
type: Stoichiometry
physical entity: Thiamine
stoichiometric coefficient: 1.0

eco ECO:0000250 15
type: UnificationXref
id: ECO:0000250
db: eco

PARTICIPANT STOICHIOMETRY r167 34
type: Stoichiometry
physical entity: Thiamine triphosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r171 50
type: Stoichiometry
physical entity: 5-(2-Hydroxyethyl)-4-methylthiazole
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r169 30
type: Stoichiometry
physical entity: Thiamine diphosphate
stoichiometric coefficient: 1.0

uniprot P41888 6
type: UnificationXref
id: P41888
db: uniprot

Thiamine triphosphatase
type: ProteinReference
xref: P03184
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Thiamine metabolism.PROTEIN.GENERIC.Thiamine_br_triphosphatase
comment: ENTITY_REFERENCE_NOTES= Long Name: Thiamine triphosphatase Synonym: Synonym not specified Accession: P03184
member entity reference: Thiamine-triphosphatase

PARTICIPANT STOICHIOMETRY r156 60
type: Stoichiometry
physical entity: 4-Methyl 5-(2-phosphoethyl)-thiazole
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r158 55
type: Stoichiometry
physical entity: Thiamine diphosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r157 57
type: Stoichiometry
physical entity: Thiamine phosphate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Thiamine-RIGHT__5__2_Hydroxyethyl__4_methylthiazole-_r171
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r171 50
participant stoichiometry: PARTICIPANT STOICHIOMETRY r171 49
left: Thiamine
interaction type: STATE_TRANSITION
right: 5-(2-Hydroxyethyl)-4-methylthiazole

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thiamine_diphosphate-RIGHT__Thiamine_triphosphate-_r167
controller: Thiamine triphosphatase

PARTICIPANT STOICHIOMETRY r157 58
type: Stoichiometry
physical entity: Thiamine diphosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r158 56
type: Stoichiometry
physical entity: Thiamine phosphate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Thiamine-RIGHT__5__2_Hydroxyethyl__4_methylthiazole-_r170
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r170 51
participant stoichiometry: PARTICIPANT STOICHIOMETRY r170 52
left: Thiamine
interaction type: STATE_TRANSITION
right: 5-(2-Hydroxyethyl)-4-methylthiazole