Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 102

ncbitaxon 189518 11
type: UnificationXref
id: 189518
db: ncbitaxon

uniprot Q9RUV3 17
type: UnificationXref
id: Q9RUV3
db: uniprot

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot O67716 122
organism: Aquifex aeolicus

ncbitaxon 243230 18
type: UnificationXref
id: 243230
db: ncbitaxon

uniprot Q1K791 114
type: UnificationXref
id: Q1K791
db: uniprot

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 7

ncbitaxon 224324 3
type: UnificationXref
id: 224324
db: ncbitaxon

Threonine synthase
type: ProteinReference
xref: uniprot O66740 66
xref: PTHR10314:SF5
organism: Aquifex aeolicus

uniprot Q5KMM7 87
type: UnificationXref
id: Q5KMM7
db: uniprot

Threonine synthase
type: ProteinReference
xref: uniprot P74193 75
organism: Synechocystis

uniprot Q9LYU8 49
type: UnificationXref
id: Q9LYU8
db: uniprot

uniprot Q9XAI7 55
type: UnificationXref
id: Q9XAI7
db: uniprot

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 83332 78
type: UnificationXref
id: 83332
db: ncbitaxon

USG-1 protein
type: ProteinReference
xref: uniprot P08390 123
organism: Escherichia coli

uniprot P29363 73
type: UnificationXref
id: P29363
db: uniprot

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 88

Homoserine kinase
type: ProteinReference
xref: P03191
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Threonine biosynthesis.PROTEIN.GENERIC.Homoserine kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: Homoserine kinase Synonym: Synonym not specified Accession: P03191
member entity reference: Homoserine kinase
member entity reference: Probable homoserine kinase

uniprot P08495 28
type: UnificationXref
id: P08495
db: uniprot

Aspartokinase
type: ProteinReference
xref: uniprot O84367 25
organism: Chlamydia trachomatis

Aspartate semialdehyde dehydrogenase
type: Protein
entity reference: Aspartate semialdehyde dehydrogenase
comment: SPECIES_TYPE=PROTEIN

uniprot O67221 24
type: UnificationXref
id: O67221
db: uniprot

STATE_TRANSITION_LEFT__O_phospho_homoserine-_H2O-RIGHT__threonine-_PO4-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 148
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 147
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 149
left: O-phospho-homoserine
left: H2O
interaction type: STATE_TRANSITION
right: threonine
right: PO4

uniprot Q9ADB4 14
type: UnificationXref
id: Q9ADB4
db: uniprot

PTHR10314:SF5
type: RelationshipXref
id: PTHR10314:SF5
db: PANTHER Family
relationship type: By Homology

Threonine synthase
type: ProteinReference
xref: PTHR42690:SF1
xref: uniprot Q42598 82
organism: Schizosaccharomyces pombe

ncbitaxon 214684 88
type: UnificationXref
id: 214684
db: ncbitaxon

ncbitaxon 251221 7
type: UnificationXref
id: 251221
db: ncbitaxon

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q7NLV2 125
organism: Gloeobacter violaceus

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot F4K6Y8 19
organism: Arabidopsis thaliana

uniprot O84367 25
type: UnificationXref
id: O84367
db: uniprot

uniprot Q7UMB6 42
type: UnificationXref
id: Q7UMB6
db: uniprot

Aspartokinase
type: ProteinReference
xref: uniprot O67221 24
organism: Aquifex aeolicus

ncbitaxon 224308 5
type: UnificationXref
id: 224308
db: ncbitaxon

uniprot Q9RRU5 119
type: UnificationXref
id: Q9RRU5
db: uniprot

uniprot Q8IYQ7 95
type: UnificationXref
id: Q8IYQ7
db: uniprot

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q7UL17 126
organism: Rhodopirellula baltica

ncbitaxon 64091 102
type: UnificationXref
id: 64091
db: ncbitaxon

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q7RZC2 41
organism: Neurospora crassa

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 26

uniprot Q8TQD4 97
type: UnificationXref
id: Q8TQD4
db: uniprot

ncbitaxon 83333 30
type: UnificationXref
id: 83333
db: ncbitaxon

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 53

ncbitaxon 243232 86
type: UnificationXref
id: 243232
db: ncbitaxon

uniprot E9PTK4 58
type: UnificationXref
id: E9PTK4
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 91

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q9RJR6 16
organism: Streptomyces coelicolor

Homoserine dehydrogenase
type: ProteinReference
xref: P03188
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Threonine biosynthesis.PROTEIN.GENERIC.Homoserine_br_dehydrogenase
comment: ENTITY_REFERENCE_NOTES= Long Name: Homoserine dehydrogenase Synonym: Synonym not specified Accession: P03188
member entity reference: Homoserine dehydrogenase

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 32

Homoserine kinase
type: ProteinReference
xref: uniprot O67332 110
organism: Aquifex aeolicus

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 76

threonine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9X1L1 132
type: UnificationXref
id: Q9X1L1
db: uniprot

uniprot Q89V75 92
type: UnificationXref
id: Q89V75
db: uniprot

Aspartokinase
type: ProteinReference
xref: uniprot Q9XAI7 55
organism: Streptomyces coelicolor

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q9XAI8 133
organism: Streptomyces coelicolor

Aspartokinase 3
type: ProteinReference
xref: uniprot P94417 34
organism: Bacillus subtilis

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aspartokinase
type: ProteinReference
xref: uniprot Q8A7Z9 46
organism: Bacteroides thetaiotaomicron

Threonine synthase
type: ProteinReference
xref: uniprot Q9HMQ7 101
organism: Halobacterium salinarum

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 67

ncbitaxon 224911 93
type: UnificationXref
id: 224911
db: ncbitaxon

Threonine synthase
type: ProteinReference
xref: uniprot P04990 71
organism: Bacillus subtilis

Threonine synthase like 1
type: ProteinReference
xref: uniprot F1MBE1 60
organism: Bos taurus

ncbitaxon 5664 84
type: UnificationXref
id: 5664
db: ncbitaxon

aspartate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O66864 69
type: UnificationXref
id: O66864
db: uniprot

eco ECO:0000250 67
type: UnificationXref
id: ECO:0000250
db: eco

uniprot P08660 29
type: UnificationXref
id: P08660
db: uniprot

PTHR42690:SF1
type: RelationshipXref
id: PTHR42690:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F7H191 62
type: UnificationXref
id: F7H191
db: uniprot

Aspartate kinase
type: Protein
entity reference: Aspartate kinase
comment: SPECIES_TYPE=PROTEIN

Threonine synthase
type: ProteinReference
xref: PTHR10314:SF96
xref: uniprot O66864 69
organism: Aquifex aeolicus

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 37

uniprot Q9WZ16 108
type: UnificationXref
id: Q9WZ16
db: uniprot

uniprot P19582 4
type: UnificationXref
id: P19582
db: uniprot

ncbitaxon 559292 32
type: UnificationXref
id: 559292
db: ncbitaxon

Threonine synthase
type: ProteinReference
xref: PTHR42690:SF1
xref: uniprot P29363 73
organism: Pseudomonas aeruginosa

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q9ADB4 14
organism: Streptomyces coelicolor

uniprot Q8TUD6 48
type: UnificationXref
id: Q8TUD6
db: uniprot

Threonine synthase
type: ProteinReference
xref: uniprot Q9ADB3 100
organism: Streptomyces coelicolor

Homoserine kinase
type: ProteinReference
xref: uniprot Q9ADB2 118
organism: Streptomyces coelicolor

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 44

uniprot K7CKY3 64
type: UnificationXref
id: K7CKY3
db: uniprot

uniprot Q9S7B5 106
type: UnificationXref
id: Q9S7B5
db: uniprot

Aspartokinase/homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q8A541 43
organism: Bacteroides thetaiotaomicron

Homoserine kinase
type: ProteinReference
xref: uniprot Q9RRU5 119
organism: Deinococcus radiodurans

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q7NDE0 6
organism: Gloeobacter violaceus

uniprot Q9RYF8 105
type: UnificationXref
id: Q9RYF8
db: uniprot

Aspartate kinase-homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q69LG7 38
organism: Oryza sativa

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 23

P03188
type: UnificationXref
id: P03188
db: PANTHER Pathway Component

P03189
type: UnificationXref
id: P03189
db: PANTHER Pathway Component

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 80

uniprot P04948 112
type: UnificationXref
id: P04948
db: uniprot

Threonine synthase
type: ProteinReference
xref: PTHR10314:SF5
xref: uniprot Q58860 85
organism: Methanocaldococcus jannaschii

uniprot Q00063 79
type: UnificationXref
id: Q00063
db: uniprot

uniprot P16120 72
type: UnificationXref
id: P16120
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 65

Threonine synthase-like 2
type: ProteinReference
xref: uniprot Q5M7T9 89
organism: Rattus norvegicus

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q9RSW3 131
organism: Deinococcus radiodurans

uniprot O66740 66
type: UnificationXref
id: O66740
db: uniprot

Homoserine kinase
type: ProteinReference
xref: uniprot Q1K791 114
organism: Neurospora crassa

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_aspartate-RIGHT__ADP-_aspartyl_4_phosphate-_r1
controller: Aspartate kinase

uniprot Q9XAI8 133
type: UnificationXref
id: Q9XAI8
db: uniprot

uniprot Q4QFV0 83
type: UnificationXref
id: Q4QFV0
db: uniprot

uniprot Q8TTK1 129
type: UnificationXref
id: Q8TTK1
db: uniprot

uniprot Q7NLV2 125
type: UnificationXref
id: Q7NLV2
db: uniprot

P03191
type: UnificationXref
id: P03191
db: PANTHER Pathway Component

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q8TMT0 12
organism: Methanosarcina acetivorans

P03192
type: UnificationXref
id: P03192
db: PANTHER Pathway Component

uniprot P17423 113
type: UnificationXref
id: P17423
db: uniprot

P03190
type: UnificationXref
id: P03190
db: PANTHER Pathway Component

ncbitaxon 178306 99
type: UnificationXref
id: 178306
db: ncbitaxon

Aspartate kinase
type: ProteinReference
xref: uniprot Q7NJQ8 40
organism: Gloeobacter violaceus

uniprot P9WG59 77
type: UnificationXref
id: P9WG59
db: uniprot

PARTICIPANT STOICHIOMETRY r5 149
type: Stoichiometry
physical entity: threonine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 148
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

ncbitaxon 226186 44
type: UnificationXref
id: 226186
db: ncbitaxon

Lysine-sensitive aspartokinase 3
type: ProteinReference
xref: uniprot P08660 29
organism: Escherichia coli

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q8F059 10
organism: Leptospira interrogans

ncbitaxon 243274 53
type: UnificationXref
id: 243274
db: ncbitaxon

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 11

PARTICIPANT STOICHIOMETRY r5 147
type: Stoichiometry
physical entity: O-phospho-homoserine
stoichiometric coefficient: 1.0

Homoserine kinase
type: ProteinReference
xref: uniprot Q7NLJ6 115
organism: Gloeobacter violaceus

uniprot O67332 110
type: UnificationXref
id: O67332
db: uniprot

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 18

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 96

Aspartokinase
type: ProteinReference
xref: uniprot Q9RUL9 50
organism: Deinococcus radiodurans

uniprot Q9WZ15 120
type: UnificationXref
id: Q9WZ15
db: uniprot

uniprot P10869 31
type: UnificationXref
id: P10869
db: uniprot

uniprot O94671 27
type: UnificationXref
id: O94671
db: uniprot

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 86

Homoserine kinase
type: ProteinReference
xref: uniprot Q8L7R2 117
organism: Arabidopsis thaliana

Threonine synthase like 1
type: ProteinReference
xref: uniprot E2RR17 56
organism: Canis lupus familiaris

ncbitaxon 9615 57
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q42598 82
type: UnificationXref
id: Q42598
db: uniprot

By Homology
type: RelationshipTypeVocabulary

ncbitaxon 284811 80
type: UnificationXref
id: 284811
db: ncbitaxon

uniprot Q9HMQ7 101
type: UnificationXref
id: Q9HMQ7
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 20

STATE_TRANSITION_LEFT__NADPH-_aspartyl_4_phosphate-RIGHT__aspartate_semialdehyde-_NADP-_PO4-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 134
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 138
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 136
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 137
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 135
left: aspartyl-4-phosphate
left: NADPH
interaction type: STATE_TRANSITION
right: aspartate-semialdehyde
right: NADP
right: PO4

uniprot Q80W22 90
type: UnificationXref
id: Q80W22
db: uniprot

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q8TTK1 129
organism: Methanosarcina acetivorans

Homoserine kinase
type: ProteinReference
xref: uniprot P04948 112
organism: Bacillus subtilis

uniprot P00547 111
type: UnificationXref
id: P00547
db: uniprot

Lysine-sensitive aspartokinase III
type: ProteinReference
xref: uniprot Q8A6I3 45
organism: Bacteroides thetaiotaomicron

uniprot Q8S1X5 128
type: UnificationXref
id: Q8S1X5
db: uniprot

ncbitaxon 10090 91
type: UnificationXref
id: 10090
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r2 140
type: Stoichiometry
physical entity: aspartate-semialdehyde
stoichiometric coefficient: 1.0

uniprot Q9X1K6 54
type: UnificationXref
id: Q9X1K6
db: uniprot

PARTICIPANT STOICHIOMETRY r2 142
type: Stoichiometry
physical entity: homoserine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 141
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Putative threonine synthase
type: ProteinReference
xref: uniprot Q9KXU8 104
organism: Streptomyces coelicolor

ncbitaxon 100226 15
type: UnificationXref
id: 100226
db: ncbitaxon

ncbitaxon 9598 65
type: UnificationXref
id: 9598
db: ncbitaxon

Threonine synthase
type: ProteinReference
xref: uniprot Q9HRU4 103
organism: Halobacterium salinarum

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 78

uniprot Q1K7N1 36
type: UnificationXref
id: Q1K7N1
db: uniprot

Threonine synthase
type: ProteinReference
xref: PTHR42690:SF1
xref: uniprot Q00063 79
organism: Ashbya gossypii

uniprot Q9HRU4 103
type: UnificationXref
id: Q9HRU4
db: uniprot

uniprot F4K6Y8 19
type: UnificationXref
id: F4K6Y8
db: uniprot

uniprot Q8BH55 94
type: UnificationXref
id: Q8BH55
db: uniprot

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Threonine synthase
type: ProteinReference
xref: uniprot Q89V75 92
organism: Bradyrhizobium diazoefficiens

ncbitaxon 9913 61
type: UnificationXref
id: 9913
db: ncbitaxon

Probable aspartokinase
type: ProteinReference
xref: uniprot Q7UMB6 42
organism: Rhodopirellula baltica

uniprot Q7UFK4 8
type: UnificationXref
id: Q7UFK4
db: uniprot

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 30

Homoserine dehydrogenase
type: Protein
entity reference: Homoserine dehydrogenase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9544 63
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot P04990 71
type: UnificationXref
id: P04990
db: uniprot

Homoserine kinase
type: ProteinReference
xref: uniprot P00547 111
organism: Escherichia coli

PARTICIPANT STOICHIOMETRY r2 139
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

ncbitaxon 39947 39
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q8A1M5 127
type: UnificationXref
id: Q8A1M5
db: uniprot

uniprot Q5M7T9 89
type: UnificationXref
id: Q5M7T9
db: uniprot

Threonine synthase 2, chloroplastic
type: ProteinReference
xref: uniprot Q9SSP5 107
organism: Arabidopsis thaliana

STATE_TRANSITION_LEFT__NADPH-_aspartate_semialdehyde-RIGHT__NADP-_homoserine-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 139
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 140
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 141
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 142
left: aspartate-semialdehyde
left: NADPH
interaction type: STATE_TRANSITION
right: homoserine
right: NADP

Threonine synthase-like 1
type: ProteinReference
xref: uniprot Q8BH55 94
organism: Mus musculus

uniprot O43056 109
type: UnificationXref
id: O43056
db: uniprot

Aspartate kinase
type: ProteinReference
xref: P03189
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Aspartate kinase Synonym: Synonym not specified Accession: P03189
comment: ENTITY_REFERENCE_ID_DESC=Threonine biosynthesis.PROTEIN.GENERIC.Aspartate kinase
member entity reference: Aspartokinase 2
member entity reference: Homoserine dehydrogenase
member entity reference: Probable aspartokinase
member entity reference: Aspartokinase
member entity reference: Aspartokinase 1, chloroplastic
member entity reference: Lysine-sensitive aspartokinase 3
member entity reference: Aspartokinase/homoserine dehydrogenase
member entity reference: Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic
member entity reference: Aspartokinase 2, chloroplastic
member entity reference: Probable homoserine dehydrogenase
member entity reference: Aspartate kinase
member entity reference: Aspartokinase 1
member entity reference: Aspartokinase 3
member entity reference: Aspartate kinase-homoserine dehydrogenase
member entity reference: Lysine-sensitive aspartokinase III
member entity reference: Aspartokinase II

STATE_TRANSITION_LEFT__ATP-_aspartate-RIGHT__ADP-_aspartyl_4_phosphate-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 144
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 145
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 146
left: ATP
left: aspartate
interaction type: STATE_TRANSITION
right: aspartyl-4-phosphate
right: ADP

uniprot Q9KXU8 104
type: UnificationXref
id: Q9KXU8
db: uniprot

Threonine synthase-like 1
type: ProteinReference
xref: uniprot Q8IYQ7 95
organism: Homo sapiens

uniprot Q8F4A7 116
type: UnificationXref
id: Q8F4A7
db: uniprot

uniprot Q9SSP5 107
type: UnificationXref
id: Q9SSP5
db: uniprot

uniprot O60163 22
type: UnificationXref
id: O60163
db: uniprot

ncbitaxon 9606 96
type: UnificationXref
id: 9606
db: ncbitaxon

Aspartokinase II
type: ProteinReference
xref: uniprot Q9WZ17 52
organism: Thermotoga maritima

uniprot B9DGS8 121
type: UnificationXref
id: B9DGS8
db: uniprot

Threonine synthase
type: ProteinReference
xref: uniprot Q9WZ16 108
organism: Thermotoga maritima

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 5

Homoserine kinase
type: ProteinReference
xref: uniprot Q9WZ15 120
organism: Thermotoga maritima

uniprot Q69LG7 38
type: UnificationXref
id: Q69LG7
db: uniprot

Probable homoserine kinase
type: ProteinReference
xref: uniprot O43056 109
organism: Schizosaccharomyces pombe

uniprot Q7NDE0 6
type: UnificationXref
id: Q7NDE0
db: uniprot

ncbitaxon 367110 37
type: UnificationXref
id: 367110
db: ncbitaxon

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot P31116 33
organism: Saccharomyces cerevisiae

uniprot Q8A7Z9 46
type: UnificationXref
id: Q8A7Z9
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 61

Threonine synthase, putative
type: ProteinReference
xref: PTHR42690:SF1
xref: uniprot Q5KMM7 87
organism: Cryptococcus neoformans

uniprot P94417 34
type: UnificationXref
id: P94417
db: uniprot

Aspartokinase 2, chloroplastic
type: ProteinReference
xref: uniprot O23653 21
organism: Arabidopsis thaliana

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 63

PARTICIPANT STOICHIOMETRY r5 150
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

uniprot Q8L7R2 117
type: UnificationXref
id: Q8L7R2
db: uniprot

Aspartokinase 2
type: ProteinReference
xref: uniprot P08495 28
organism: Bacillus subtilis

uniprot Q8A6I3 45
type: UnificationXref
id: Q8A6I3
db: uniprot

STATE_TRANSITION_LEFT__ATP-_homoserine-RIGHT__ADP-_O_phospho_homoserine-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 152
left: ATP
left: homoserine
interaction type: STATE_TRANSITION
right: O-phospho-homoserine
right: ADP

Threonine biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__ATP-_aspartate-RIGHT__ADP-_aspartyl_4_phosphate-_r1
pathway component: STATE_TRANSITION_LEFT__NADPH-_aspartyl_4_phosphate-RIGHT__aspartate_semialdehyde-_NADP-_PO4-_r3
pathway component: STATE_TRANSITION_LEFT__O_phospho_homoserine-_H2O-RIGHT__threonine-_PO4-_r5
pathway component: STATE_TRANSITION_LEFT__ATP-_homoserine-RIGHT__ADP-_O_phospho_homoserine-_r4
pathway component: STATE_TRANSITION_LEFT__NADPH-_aspartate_semialdehyde-RIGHT__NADP-_homoserine-_r2
xref: PANTHER Pathway P02781 1
comment: MODEL_NOTES= The biosynthesis of the amino acid threonine critical for protein biosynthesis. Website=www.biocyc.org/Ecoli/Pathways/ free text=Biochemistry (text) Voet and Voet

uniprot Q1K5C3 81
type: UnificationXref
id: Q1K5C3
db: uniprot

uniprot Q9RUL9 50
type: UnificationXref
id: Q9RUL9
db: uniprot

uniprot Q9LQ96 130
type: UnificationXref
id: Q9LQ96
db: uniprot

uniprot O23653 21
type: UnificationXref
id: O23653
db: uniprot

Homoserine kinase
type: Protein
entity reference: Homoserine kinase
comment: SPECIES_TYPE=PROTEIN

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P74193 75
type: UnificationXref
id: P74193
db: uniprot

uniprot Q8ZUA2 98
type: UnificationXref
id: Q8ZUA2
db: uniprot

uniprot Q9ADB2 118
type: UnificationXref
id: Q9ADB2
db: uniprot

uniprot Q7NLJ6 115
type: UnificationXref
id: Q7NLJ6
db: uniprot

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 13

Threonine synthase
type: Protein
entity reference: Threonine synthase
comment: SPECIES_TYPE=PROTEIN

uniprot P08390 123
type: UnificationXref
id: P08390
db: uniprot

O-phospho-homoserine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aspartokinase
type: ProteinReference
xref: uniprot Q1K7N1 36
organism: Neurospora crassa

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q04797 124
organism: Bacillus subtilis

uniprot Q8TMT0 12
type: UnificationXref
id: Q8TMT0
db: uniprot

PARTICIPANT STOICHIOMETRY r1 144
type: Stoichiometry
physical entity: aspartate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 145
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 146
type: Stoichiometry
physical entity: aspartyl-4-phosphate
stoichiometric coefficient: 1.0

Probable homoserine dehydrogenase
type: ProteinReference
xref: uniprot O94671 27
organism: Schizosaccharomyces pombe

uniprot Q9SA18 51
type: UnificationXref
id: Q9SA18
db: uniprot

Aspartokinase 1
type: ProteinReference
xref: uniprot Q04795 35
organism: Bacillus subtilis

PARTICIPANT STOICHIOMETRY r1 143
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 59

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 3

PARTICIPANT STOICHIOMETRY r4 154
type: Stoichiometry
physical entity: O-phospho-homoserine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 153
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 152
type: Stoichiometry
physical entity: homoserine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 151
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Aspartokinase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9LYU8 49
organism: Arabidopsis thaliana

Aspartokinase
type: ProteinReference
xref: uniprot P10869 31
organism: Saccharomyces cerevisiae

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 57

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH-_aspartate_semialdehyde-RIGHT__NADP-_homoserine-_r2
controller: Homoserine dehydrogenase

Aspartokinase
type: ProteinReference
xref: uniprot Q8F865 47
organism: Leptospira interrogans

ncbitaxon 1111708 76
type: UnificationXref
id: 1111708
db: ncbitaxon

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot O67677 2
organism: Aquifex aeolicus

uniprot Q8F865 47
type: UnificationXref
id: Q8F865
db: uniprot

AT1G14820 protein
type: ProteinReference
xref: uniprot B9DGS8 121
organism: Arabidopsis thaliana

Threonine synthase
type: ProteinReference
xref: uniprot P16120 72
xref: PTHR42690:SF1
organism: Saccharomyces cerevisiae

Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9SA18 51
organism: Arabidopsis thaliana

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q9RUV3 17
organism: Deinococcus radiodurans

uniprot O67677 2
type: UnificationXref
id: O67677
db: uniprot

Threonine synthase
type: ProteinReference
xref: PTHR42690:SF1
xref: uniprot Q9RYF8 105
organism: Deinococcus radiodurans

Threonine synthase
type: ProteinReference
xref: uniprot Q8ZUA2 98
organism: Pyrobaculum aerophilum

Bradyrhizobium diazoefficiens
type: BioSource
xref: ncbitaxon 224911 93

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 99

uniprot Q8F059 10
type: UnificationXref
id: Q8F059
db: uniprot

uniprot Q04795 35
type: UnificationXref
id: Q04795
db: uniprot

aspartate-semialdehyde
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 9

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 15

Os01g0926800 protein
type: ProteinReference
xref: uniprot Q8S1X5 128
organism: Oryza sativa

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__O_phospho_homoserine-_H2O-RIGHT__threonine-_PO4-_r5
controller: Threonine synthase

uniprot Q8A541 43
type: UnificationXref
id: Q8A541
db: uniprot

Threonine synthase
type: ProteinReference
xref: uniprot Q8TQD4 97
organism: Methanosarcina acetivorans

ncbitaxon 10116 59
type: UnificationXref
id: 10116
db: ncbitaxon

Probable aspartokinase
type: ProteinReference
xref: uniprot O60163 22
organism: Schizosaccharomyces pombe

Threonine synthase-like 1
type: ProteinReference
xref: uniprot E9PTK4 58
organism: Rattus norvegicus

PTHR10314:SF96
type: RelationshipXref
id: PTHR10314:SF96
db: PANTHER Family
relationship type: By Homology

Putative threonine synthase
type: ProteinReference
xref: uniprot Q4QFV0 83
organism: Leishmania major

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

ncbitaxon 208964 74
type: UnificationXref
id: 208964
db: ncbitaxon

uniprot O67716 122
type: UnificationXref
id: O67716
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_homoserine-RIGHT__ADP-_O_phospho_homoserine-_r4
controller: Homoserine kinase

Aspartokinase
type: ProteinReference
xref: uniprot Q9X1K6 54
organism: Thermotoga maritima

uniprot P31116 33
type: UnificationXref
id: P31116
db: uniprot

uniprot Q58860 85
type: UnificationXref
id: Q58860
db: uniprot

uniprot Q9RJR6 16
type: UnificationXref
id: Q9RJR6
db: uniprot

uniprot E2RR17 56
type: UnificationXref
id: E2RR17
db: uniprot

ncbitaxon 284812 23
type: UnificationXref
id: 284812
db: ncbitaxon

homoserine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Polyphosphoinositide binding protein, putative
type: ProteinReference
xref: uniprot Q9LQ96 130
organism: Arabidopsis thaliana

uniprot Q04797 124
type: UnificationXref
id: Q04797
db: uniprot

Aspartokinase
type: ProteinReference
xref: uniprot Q8TUD6 48
organism: Methanosarcina acetivorans

uniprot Q9WZ17 52
type: UnificationXref
id: Q9WZ17
db: uniprot

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q9X1L1 132
organism: Thermotoga maritima

aspartyl-4-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PANTHER Pathway P02781 1
type: UnificationXref
id: P02781
db: PANTHER Pathway

ncbitaxon 188937 13
type: UnificationXref
id: 188937
db: ncbitaxon

Homoserine kinase
type: ProteinReference
xref: uniprot P17423 113
organism: Saccharomyces cerevisiae

uniprot Q9ADB3 100
type: UnificationXref
id: Q9ADB3
db: uniprot

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 272561 26
type: UnificationXref
id: 272561
db: ncbitaxon

Threonine synthase-like 1
type: ProteinReference
xref: uniprot F7H191 62
organism: Macaca mulatta

Leishmania major
type: BioSource
xref: ncbitaxon 5664 84

Threonine synthase
type: ProteinReference
xref: PTHR42690:SF1
xref: uniprot Q1K5C3 81
organism: Neurospora crassa

Homoserine kinase
type: ProteinReference
xref: uniprot Q8F4A7 116
organism: Leptospira interrogans

ncbitaxon 243090 9
type: UnificationXref
id: 243090
db: ncbitaxon

uniprot P00934 70
type: UnificationXref
id: P00934
db: uniprot

Threonine synthase
type: ProteinReference
xref: P03190
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Threonine synthase Synonym: Synonym not specified Accession: P03190
comment: ENTITY_REFERENCE_ID_DESC=Threonine biosynthesis.PROTEIN.GENERIC.Threonine synthase
member entity reference: Threonine synthase
member entity reference: Threonine synthase like 1
member entity reference: Threonine synthase-like 1
member entity reference: Threonine synthase, putative
member entity reference: Putative threonine synthase
member entity reference: Threonine synthase 2, chloroplastic
member entity reference: Threonine synthase-like 2
member entity reference: THNSL1 isoform 1
member entity reference: Threonine synthase 1, chloroplastic

Threonine synthase
type: ProteinReference
xref: uniprot P9WG59 77
organism: Mycobacterium tuberculosis

Threonine synthase
type: ProteinReference
xref: PTHR42690:SF1
xref: uniprot P00934 70
organism: Escherichia coli

THNSL1 isoform 1
type: ProteinReference
xref: uniprot K7CKY3 64
organism: Pan troglodytes

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q8A1M5 127
organism: Bacteroides thetaiotaomicron

Aspartate semialdehyde dehydrogenase
type: ProteinReference
xref: P03192
comment: ENTITY_REFERENCE_ID_DESC=Threonine biosynthesis.PROTEIN.GENERIC.Aspartate_br_semialdehyde_br_dehydrogenase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Aspartate semialdehyde dehydrogenase Synonym: Synonym not specified Accession: P03192
member entity reference: Aspartate-semialdehyde dehydrogenase
member entity reference: Polyphosphoinositide binding protein, putative
member entity reference: Os01g0926800 protein
member entity reference: AT1G14820 protein
member entity reference: USG-1 protein

Threonine synthase-like 2
type: ProteinReference
xref: uniprot Q80W22 90
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r3 134
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Threonine synthase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9S7B5 106
organism: Arabidopsis thaliana

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot P19582 4
organism: Bacillus subtilis

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q7UFK4 8
organism: Rhodopirellula baltica

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r3 135
type: Stoichiometry
physical entity: aspartyl-4-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 136
type: Stoichiometry
physical entity: aspartate-semialdehyde
stoichiometric coefficient: 1.0

uniprot Q9RSW3 131
type: UnificationXref
id: Q9RSW3
db: uniprot

PARTICIPANT STOICHIOMETRY r3 137
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

uniprot F1MBE1 60
type: UnificationXref
id: F1MBE1
db: uniprot

PARTICIPANT STOICHIOMETRY r3 138
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH-_aspartyl_4_phosphate-RIGHT__aspartate_semialdehyde-_NADP-_PO4-_r3
controller: Aspartate semialdehyde dehydrogenase

uniprot Q7UL17 126
type: UnificationXref
id: Q7UL17
db: uniprot

uniprot Q7NJQ8 40
type: UnificationXref
id: Q7NJQ8
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 39

ncbitaxon 3702 20
type: UnificationXref
id: 3702
db: ncbitaxon

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 74

uniprot Q7RZC2 41
type: UnificationXref
id: Q7RZC2
db: uniprot