uniprot Q6YNX4 516
type: UnificationXref
id: Q6YNX4
db: uniprot

uniprot F1P354 60
type: UnificationXref
id: F1P354
db: uniprot

uniprot G3V6P8 390
type: UnificationXref
id: G3V6P8
db: uniprot

uniprot Q04759 307
type: UnificationXref
id: Q04759
db: uniprot

uniprot P38408 422
type: UnificationXref
id: P38408
db: uniprot

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: PTHR45701:SF3
xref: uniprot M9PE71 191
organism: Drosophila melanogaster

uniprot E2R2S3 341
type: UnificationXref
id: E2R2S3
db: uniprot

PTHR24356:SF303
type: RelationshipXref
id: PTHR24356:SF303
db: PANTHER Family
relationship type: By Homology

Complex (SNARE COMPLEX/Ca2+)
type: Complex
component stoichiometry: Ca2 PLUS s23 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: SNARE COMPLEX s21 sa12 STOICHIOMETRY ID COMPLEX
component: SNARE COMPLEX
component: Ca2+
feature: COMPLEX BINDING FEATURE s40 a51 593
feature: COMPLEX BINDING FEATURE s40 a51 591
cellular location: exocytic vesicle

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: uniprot Q02294 555
xref: PTHR45628:SF6
organism: Rattus norvegicus

uniprot Q02156 305
type: UnificationXref
id: Q02156
db: uniprot

PARTICIPANT STOICHIOMETRY re11 595
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/ TRH Receptor)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 596
type: Stoichiometry
physical entity: TRH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 597
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/ TRH Receptor/TRH)
stoichiometric coefficient: 1.0

uniprot Q8CC27 562
type: UnificationXref
id: Q8CC27
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 469
organism: Gallus gallus

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Thyroid hormone release
controller: Thyrotropin

Syntaxin-3
type: ProteinReference
xref: uniprot Q64704 229
xref: PTHR19957:SF34
organism: Mus musculus

uniprot P29387 416
type: UnificationXref
id: P29387
db: uniprot

uniprot E9GJ31 349
type: UnificationXref
id: E9GJ31
db: uniprot

uniprot C3ZSF0 335
type: UnificationXref
id: C3ZSF0
db: uniprot

Ca2+ channel
type: Protein
entity reference: Ca2+ channel
feature: ACTIVE 163
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot D4A978 53
type: UnificationXref
id: D4A978
db: uniprot

uniprot A0A1D5QG31 322
type: UnificationXref
id: A0A1D5QG31
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 327
organism: Bos taurus

uniprot Q80SZ7 487
type: UnificationXref
id: Q80SZ7
db: uniprot

uniprot P62871 435
type: UnificationXref
id: P62871
db: uniprot

uniprot F7F580 382
type: UnificationXref
id: F7F580
db: uniprot

uniprot P60880 207
type: UnificationXref
id: P60880
db: uniprot

uniprot Q10282 453
type: UnificationXref
id: Q10282
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 444
organism: Bos taurus

uniprot A0A2I3RQJ8 246
type: UnificationXref
id: A0A2I3RQJ8
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot A8WR64 253
organism: Caenorhabditis briggsae

uniprot P17252 291
type: UnificationXref
id: P17252
db: uniprot

uniprot P19174 106
type: UnificationXref
id: P19174
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 26

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6XYX9 180
organism: Monodelphis domestica

uniprot P54311 432
type: UnificationXref
id: P54311
db: uniprot

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

uniprot P63026 210
type: UnificationXref
id: P63026
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A8X1E0 50
organism: Caenorhabditis briggsae

Protein kinase C-like 3
type: ProteinReference
xref: uniprot Q19266 311
xref: PTHR24356:SF303
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q5RKP9 467
organism: Danio rerio

uniprot A0A3Q1MRR6 249
type: UnificationXref
id: A0A3Q1MRR6
db: uniprot

uniprot O01661 547
type: UnificationXref
id: O01661
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 439
organism: Homo sapiens

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 438
organism: Mus musculus

uniprot F1PL90 61
type: UnificationXref
id: F1PL90
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 436
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 437
organism: Homo sapiens

uniprot A0A1D5Q3D7 36
type: UnificationXref
id: A0A1D5Q3D7
db: uniprot

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 441
organism: Mus musculus

uniprot Q90XF2 320
type: UnificationXref
id: Q90XF2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 440
organism: Mus musculus

uniprot Q02158 116
type: UnificationXref
id: Q02158
db: uniprot

Thyrotropin-releasing hormone receptor signaling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re6
pathway component: PHYSICAL_STIMULATION
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re4
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_re1
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_Protein__TRH_Receptor_-_TRH-RIGHT__Complex__GDP_G_Protein__TRH_Receptor_TRH_-_re11
pathway component: TRANSPORT_LEFT__TRH-RIGHT__TRH-_re10
pathway component: HETERODIMER_ASSOCIATION_LEFT__SNARE_COMPLEX-_Ca2_PLUS_-RIGHT__Complex__SNARE_COMPLEX_Ca2_PLUS__-_re15
pathway component: UNKNOWN_TRANSITION_LEFT__ProTRH__Pro_Thyrotropin_releasing_Hormone_-RIGHT__TRH-_re9
pathway component: DISSOCIATION_LEFT__GTP-_Complex__GDP_G_Protein__TRH_Receptor_TRH_-RIGHT__Complex__GTP_G_Protein_-_GDP-_Complex__TRH_Receptor_TRH_-_re12
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re2
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re3
pathway component: TRANSPORT_LEFT__Thyrotropin-RIGHT__Thyrotropin-_re14
xref: PANTHER Pathway P04394 1
comment: MODEL_NOTES=Panther Pathway: P04394 http://www.pdg.cnb.uam.es/UniPub/iHOP/gs/125698.html

uniprot A0A2I3SR99 167
type: UnificationXref
id: A0A2I3SR99
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot F6UFJ7 177
xref: PTHR19305:SF9
organism: Macaca mulatta

PTHR10218:SF316
type: RelationshipXref
id: PTHR10218:SF316
db: PANTHER Family
relationship type: By Homology

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q6Z3Y9 133
organism: Oryza sativa

ncbitaxon 9544 21
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot F7EPG4 184
type: UnificationXref
id: F7EPG4
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q01970 115
xref: PTHR10336:SF11
organism: Homo sapiens

uniprot Q00722 114
type: UnificationXref
id: Q00722
db: uniprot

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

uniprot H2QKD0 88
type: UnificationXref
id: H2QKD0
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 138

uniprot Q5TZ66 226
type: UnificationXref
id: Q5TZ66
db: uniprot

uniprot J9JHK9 93
type: UnificationXref
id: J9JHK9
db: uniprot

uniprot P63025 209
type: UnificationXref
id: P63025
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 435
organism: Bos taurus

uniprot F7G1U7 385
type: UnificationXref
id: F7G1U7
db: uniprot

uniprot G5EBH0 84
type: UnificationXref
id: G5EBH0
db: uniprot

uniprot P40977 110
type: UnificationXref
id: P40977
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F6ZC55 78
organism: Monodelphis domestica

PTHR10218:SF328
type: RelationshipXref
id: PTHR10218:SF328
db: PANTHER Family
relationship type: By Homology

PTHR10218:SF329
type: RelationshipXref
id: PTHR10218:SF329
db: PANTHER Family
relationship type: By Homology

uniprot A8KBH6 252
type: UnificationXref
id: A8KBH6
db: uniprot

PTHR24356:SF347
type: RelationshipXref
id: PTHR24356:SF347
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 375
organism: Macaca mulatta

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A1D5QXV8 39
xref: PTHR10336:SF29
organism: Macaca mulatta

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1Q376 65
organism: Canis lupus familiaris

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60879 206
xref: PTHR19305:SF5
organism: Mus musculus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60878 205
xref: PTHR19305:SF5
organism: Gallus gallus

GO GO:0005783 4
type: UnificationXref
id: GO:0005783
db: GO

uniprot P60878 205
type: UnificationXref
id: P60878
db: uniprot

uniprot F6XWE8 367
type: UnificationXref
id: F6XWE8
db: uniprot

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 223
organism: Emericella nidulans

uniprot F6RA79 265
type: UnificationXref
id: F6RA79
db: uniprot

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 468
organism: Xenopus tropicalis

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60877 204
organism: Macaca mulatta

Ca2 PLUS s23 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

IP3
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P43425 424
type: UnificationXref
id: P43425
db: uniprot

uniprot F7H3B3 273
type: UnificationXref
id: F7H3B3
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60880 207
organism: Homo sapiens

uniprot P63024 208
type: UnificationXref
id: P63024
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF31
xref: uniprot A0A2I3RV12 42
organism: Pan troglodytes

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q2KJD2 221
organism: Bos taurus

ncbitaxon 665079 331
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot P13678 289
type: UnificationXref
id: P13678
db: uniprot

Protein kinase C-like 1B
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot P34885 297
organism: Caenorhabditis elegans

uniprot Q66JF0 473
type: UnificationXref
id: Q66JF0
db: uniprot

uniprot P12656 512
type: UnificationXref
id: P12656
db: uniprot

uniprot F6RBM2 500
type: UnificationXref
id: F6RBM2
db: uniprot

uniprot Q22070 122
type: UnificationXref
id: Q22070
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63044 212
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63045 213
xref: PTHR45701:SF5
organism: Rattus norvegicus

uniprot O00555 546
type: UnificationXref
id: O00555
db: uniprot

Thyrotropin-releasing hormone receptor
type: ProteinReference
xref: uniprot Q01717 29
xref: PTHR46061:SF2
organism: Rattus norvegicus

Synaptobrevin-1
type: ProteinReference
xref: uniprot O02495 193
xref: PTHR45701:SF3
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: uniprot A1L271 326
organism: Danio rerio

uniprot F7CXD0 376
type: UnificationXref
id: F7CXD0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 335
organism: Branchiostoma floridae

uniprot F7D5G3 81
type: UnificationXref
id: F7D5G3
db: uniprot

uniprot F6UFJ7 177
type: UnificationXref
id: F6UFJ7
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q7ZUC5 319
xref: PTHR24356:SF365
organism: Danio rerio

G protein subunit alpha 14
type: ProteinReference
xref: uniprot A0A2I3TRC4 323
xref: PTHR10218:SF213
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re2 609
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot H2RCB8 190
type: UnificationXref
id: H2RCB8
db: uniprot

Vesicle-associated membrane protein 8 (Endobrevin)
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q7ZUC1 233
organism: Danio rerio

uniprot H9ZA60 92
type: UnificationXref
id: H9ZA60
db: uniprot

PARTICIPANT STOICHIOMETRY re2 608
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: uniprot Q9QW07 158
xref: PTHR10336:SF106
organism: Rattus norvegicus

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

uniprot E2RGI5 344
type: UnificationXref
id: E2RGI5
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63027 211
xref: PTHR45701:SF5
organism: Homo sapiens

uniprot A8X8S6 170
type: UnificationXref
id: A8X8S6
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63026 210
organism: Bos taurus

uniprot Q5R1X1 225
type: UnificationXref
id: Q5R1X1
db: uniprot

uniprot A0A3Q2U0G2 48
type: UnificationXref
id: A0A3Q2U0G2
db: uniprot

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: PTHR45628:SF3
xref: uniprot P97445 553
organism: Mus musculus

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

Putative protein kinase C delta type homolog
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot P83099 302
organism: Drosophila melanogaster

Thyrotropin-releasing hormone receptor
type: ProteinReference
xref: PTHR46061:SF2
xref: uniprot F7DWM0 20
organism: Macaca mulatta

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 208
organism: Mus musculus

uniprot F6VVA6 75
type: UnificationXref
id: F6VVA6
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63025 209
organism: Rattus norvegicus

Protein kinase C
type: ProteinReference
xref: uniprot F6RA79 265
xref: PTHR24356:SF193
organism: Monodelphis domestica

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 358
organism: Ornithorhynchus anatinus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A8XTZ1 52
organism: Caenorhabditis briggsae

uniprot Q6PHV0 231
type: UnificationXref
id: Q6PHV0
db: uniprot

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 343
organism: Canis lupus familiaris

uniprot G2HIJ9 185
type: UnificationXref
id: G2HIJ9
db: uniprot

uniprot Q7ZUC1 233
type: UnificationXref
id: Q7ZUC1
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot O70404 197
organism: Mus musculus

uniprot F7EBE7 378
type: UnificationXref
id: F7EBE7
db: uniprot

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 405
organism: Homo sapiens

VAMP2 isoform 3
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot H2RCB8 190
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re3 607
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 606
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

uniprot E2RQM0 55
type: UnificationXref
id: E2RQM0
db: uniprot

uniprot A0A1D5Q4D0 37
type: UnificationXref
id: A0A1D5Q4D0
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot F6Z5I2 182
organism: Monodelphis domestica

uniprot Q9VH76 241
type: UnificationXref
id: Q9VH76
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q21754 121
organism: Caenorhabditis elegans

uniprot Q7SY24 317
type: UnificationXref
id: Q7SY24
db: uniprot

uniprot A8WRW6 527
type: UnificationXref
id: A8WRW6
db: uniprot

uniprot A0A2I3RVP2 43
type: UnificationXref
id: A0A2I3RVP2
db: uniprot

uniprot F1Q376 65
type: UnificationXref
id: F1Q376
db: uniprot

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: G Protein s4 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s3 sa1 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-Protein
feature: ACTIVE 163
feature: COMPLEX BINDING FEATURE s10 a11 573
feature: COMPLEX BINDING FEATURE s10 a11 575
cellular location: cytosol

Voltage-dependent P/Q-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot A0A2I3T217 520
xref: PTHR45628:SF3
organism: Pan troglodytes

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

uniprot P10686 98
type: UnificationXref
id: P10686
db: uniprot

uniprot A0A3B1E663 524
type: UnificationXref
id: A0A3B1E663
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 342
organism: Canis lupus familiaris

uniprot P63216 448
type: UnificationXref
id: P63216
db: uniprot

uniprot Q8CIH5 141
type: UnificationXref
id: Q8CIH5
db: uniprot

uniprot A8WVT3 11
type: UnificationXref
id: A8WVT3
db: uniprot

Voltage-dependent L-type calcium channel subunit beta-4
type: ProteinReference
xref: uniprot O00305 545
organism: Homo sapiens

uniprot Q6DF43 474
type: UnificationXref
id: Q6DF43
db: uniprot

uniprot E2RNP2 258
type: UnificationXref
id: E2RNP2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 341
organism: Canis lupus familiaris

ncbitaxon 3702 124
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot A8X1E0 50
type: UnificationXref
id: A8X1E0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
type: ProteinReference
xref: PTHR10336:SF51
xref: uniprot Q4KWH5 127
organism: Mus musculus

uniprot Q9LY51 155
type: UnificationXref
id: Q9LY51
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

TRH Receptor s42 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRH Receptor
stoichiometric coefficient: 1.0

PTHR10336:SF80
type: RelationshipXref
id: PTHR10336:SF80
db: PANTHER Family
relationship type: By Homology

Protein kinase C iota type
type: ProteinReference
xref: uniprot Q62074 313
xref: PTHR24356:SF214
organism: Mus musculus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot Q9JID2 492
xref: PTHR10218:SF328
organism: Rattus norvegicus

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 21

uniprot Q9DAS9 490
type: UnificationXref
id: Q9DAS9
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot Q62077 129
organism: Mus musculus

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7G1U7 385
organism: Monodelphis domestica

uniprot P16885 105
type: UnificationXref
id: P16885
db: uniprot

uniprot H2QJ75 86
type: UnificationXref
id: H2QJ75
db: uniprot

PTHR10336:SF106
type: RelationshipXref
id: PTHR10336:SF106
db: PANTHER Family
relationship type: By Homology

uniprot Q6DGZ5 475
type: UnificationXref
id: Q6DGZ5
db: uniprot

uniprot O00161 192
type: UnificationXref
id: O00161
db: uniprot

Thyrotropin-releasing hormone receptor 2
type: ProteinReference
xref: uniprot Q9ERT2 33
organism: Mus musculus

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot O95721 198
xref: PTHR19305:SF9
organism: Homo sapiens

uniprot H2R368 543
type: UnificationXref
id: H2R368
db: uniprot

PTHR10336:SF51
type: RelationshipXref
id: PTHR10336:SF51
db: PANTHER Family
relationship type: By Homology

uniprot P01217 507
type: UnificationXref
id: P01217
db: uniprot

uniprot F6VPY1 364
type: UnificationXref
id: F6VPY1
db: uniprot

ncbitaxon 6669 348
type: UnificationXref
id: 6669
db: ncbitaxon

Thyrotropin-releasing hormone receptor
type: ProteinReference
xref: PTHR46061:SF2
xref: uniprot A0A1D5P3F4 5
organism: Gallus gallus

Protein kinase C iota type
type: ProteinReference
xref: uniprot P41743 298
xref: PTHR24356:SF214
organism: Homo sapiens

DISSOCIATION
type: RelationshipTypeVocabulary

Ca2+ channel
type: ProteinReference
xref: P04587
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Thyrotropin-releasing hormone receptor signaling pathway.PROTEIN.ION_CHANNEL.Ca_super_2+_endsuper__br_channel
comment: ENTITY_REFERENCE_NOTES= Long Name: Ca2+ channel Synonym: Synonym not specified Accession: P04587
member entity reference: Calcium voltage-gated channel auxiliary subunit beta 3
member entity reference: Voltage-dependent L-type calcium channel subunit beta-1
member entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
member entity reference: Voltage-dependent L-type calcium channel subunit beta-2
member entity reference: Voltage-dependent L-type calcium channel subunit beta-3
member entity reference: Voltage-dependent L-type calcium channel subunit beta-4
member entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B
member entity reference: Uncharacterized protein
member entity reference: Voltage-dependent L-type calcium channel subunit beta-3 isoform 1
member entity reference: Voltage-dependent R-type calcium channel subunit alpha-1E
member entity reference: Calcium Channel, Beta subunit
member entity reference: CACNB2 isoform 5
member entity reference: Calcium voltage-gated channel auxiliary subunit beta 2
member entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha
member entity reference: Voltage-dependent R-type calcium channel subunit alpha
member entity reference: Calcium voltage-gated channel auxiliary subunit beta 1
member entity reference: Protein CBR-UNC-2 (Fragment)
member entity reference: Protein CBR-CCB-2
member entity reference: Calcium channel, voltage-dependent, beta 4 subunit
member entity reference: AGAP002578-PB
member entity reference: Voltage-dependent N-type calcium channel subunit alpha
member entity reference: CACNB4 isoform 1
member entity reference: Calcium channel, voltage-dependent, beta 3 subunit
member entity reference: Voltage-dependent calcium channel type A subunit alpha-1

TRH
type: ProteinReference
xref: P04585
standard name: Thyrotropin-releasing hormone
comment: ENTITY_REFERENCE_ID_DESC=Thyrotropin-releasing hormone receptor signaling pathway.PROTEIN.GENERIC.TRH
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: TRH Synonym: Synonym not specified Accession: P04585
member entity reference: Thyroid stimulating hormone, beta subunit
member entity reference: Glycoprotein hormones alpha chain
member entity reference: Thyrotropin subunit beta
member entity reference: Thyroid stimulating hormone beta subunit
member entity reference: Pro-thyrotropin-releasing hormone
member entity reference: TSHB isoform 1

uniprot Q61017 472
type: UnificationXref
id: Q61017
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot K7CBH8 279
xref: PTHR24356:SF159
organism: Pan troglodytes

Voltage-dependent L-type calcium channel subunit beta-2
type: ProteinReference
xref: uniprot Q08289 559
xref: PTHR11824:SF9
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 427
organism: Homo sapiens

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 428
organism: Homo sapiens

uniprot Q05655 309
type: UnificationXref
id: Q05655
db: uniprot

Calcium voltage-gated channel auxiliary subunit beta 1
type: ProteinReference
xref: uniprot A0A2I3TBK2 521
xref: PTHR11824:SF17
organism: Pan troglodytes

uniprot E2QUL2 171
type: UnificationXref
id: E2QUL2
db: uniprot

Thyrotropin subunit beta
type: ProteinReference
xref: PTHR11515:SF5
xref: uniprot P04652 510
organism: Rattus norvegicus

ncbitaxon 7227 104
type: UnificationXref
id: 7227
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 430
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LYB4 168
xref: PTHR19957:SF34
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 429
organism: Mus musculus

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: uniprot P50148 426
xref: PTHR10218:SF316
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QDW1 164
xref: PTHR19957:SF34
organism: Macaca mulatta

uniprot D4A055 529
type: UnificationXref
id: D4A055
db: uniprot

uniprot O55017 548
type: UnificationXref
id: O55017
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SED9 175
xref: PTHR19957:SF34
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR10336:SF51
xref: uniprot F7GU82 83
organism: Macaca mulatta

uniprot E1BMG4 254
type: UnificationXref
id: E1BMG4
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7HC75 274
xref: PTHR24356:SF181
organism: Macaca mulatta

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot H2QJ75 86
organism: Pan troglodytes

Glycoprotein hormones alpha chain
type: ProteinReference
xref: PTHR11509:SF0
xref: uniprot A0A2I3TIH6 497
organism: Pan troglodytes

PTHR10336:SF33
type: RelationshipXref
id: PTHR10336:SF33
db: PANTHER Family
relationship type: By Homology

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1M324 57
organism: Rattus norvegicus

Thyrotropin subunit beta
type: ProteinReference
xref: uniprot P12656 512
xref: PTHR11515:SF5
organism: Mus musculus

PTHR10336:SF31
type: RelationshipXref
id: PTHR10336:SF31
db: PANTHER Family
relationship type: By Homology

Inactive phospholipase C-like protein 2
type: ProteinReference
xref: uniprot Q8K394 144
organism: Mus musculus

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F7D5G3 81
organism: Ornithorhynchus anatinus

uniprot P04652 510
type: UnificationXref
id: P04652
db: uniprot

PKC
type: Protein
entity reference: PKC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot A3KGF7 49
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot A0A3Q2U0G2 48
organism: Gallus gallus

uniprot P63218 450
type: UnificationXref
id: P63218
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SWI4 536
xref: PTHR11824:SF9
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6YMH2 181
organism: Macaca mulatta

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: uniprot O00555 546
xref: PTHR45628:SF3
organism: Homo sapiens

PTHR10336:SF25
type: RelationshipXref
id: PTHR10336:SF25
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot F7HBW2 541
type: UnificationXref
id: F7HBW2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HBW2 541
xref: PTHR11824:SF17
organism: Macaca mulatta

Calcium channel, voltage-dependent, beta 3 subunit
type: ProteinReference
xref: uniprot F6XPD5 539
organism: Xenopus tropicalis

uniprot A0A1D5Q7C3 519
type: UnificationXref
id: A0A1D5Q7C3
db: uniprot

PTHR10336:SF29
type: RelationshipXref
id: PTHR10336:SF29
db: PANTHER Family
relationship type: By Homology

uniprot Q28024 456
type: UnificationXref
id: Q28024
db: uniprot

uniprot P20396 513
type: UnificationXref
id: P20396
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q9BV40 235
organism: Homo sapiens

uniprot E1BZF6 530
type: UnificationXref
id: E1BZF6
db: uniprot

uniprot O60262 406
type: UnificationXref
id: O60262
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 390
organism: Rattus norvegicus

Thyrotropin releasing hormone receptor
type: ProteinReference
xref: uniprot E2R0P6 13
xref: PTHR46061:SF2
organism: Canis lupus familiaris

uniprot Q6QX43 515
type: UnificationXref
id: Q6QX43
db: uniprot

uniprot P97445 553
type: UnificationXref
id: P97445
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot F7A943 183
organism: Monodelphis domestica

uniprot F7ERP8 380
type: UnificationXref
id: F7ERP8
db: uniprot

Soluble NSF attachment protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot P83351 214
organism: Caenorhabditis elegans

uniprot Q4KWH5 127
type: UnificationXref
id: Q4KWH5
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot F1MY82 261
organism: Bos taurus

uniprot H2QAS6 276
type: UnificationXref
id: H2QAS6
db: uniprot

uniprot A0A3Q1LZY8 526
type: UnificationXref
id: A0A3Q1LZY8
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 396
organism: Pan troglodytes

uniprot G5EEN8 186
type: UnificationXref
id: G5EEN8
db: uniprot

uniprot P41743 298
type: UnificationXref
id: P41743
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot H2QDQ1 277
organism: Pan troglodytes

PTHR10336:SF11
type: RelationshipXref
id: PTHR10336:SF11
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF12
type: RelationshipXref
id: PTHR10336:SF12
db: PANTHER Family
relationship type: By Homology

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa4 588
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR10336:SF10
type: RelationshipXref
id: PTHR10336:SF10
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A2I3SHP7 44
organism: Pan troglodytes

TRANSPORT_LEFT__TRH-RIGHT__TRH-_re10
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 598
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 599
left: TRH
interaction type: TRANSPORT
right: TRH

uniprot Q9NQ66 156
type: UnificationXref
id: Q9NQ66
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P19174 106
organism: Homo sapiens

uniprot Q28H40 458
type: UnificationXref
id: Q28H40
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 451
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 450
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 449
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 448
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 447
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 446
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 445
organism: Mus musculus

uniprot A4IGZ2 328
type: UnificationXref
id: A4IGZ2
db: uniprot

uniprot P62879 439
type: UnificationXref
id: P62879
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 12

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 454
organism: Danio rerio

uniprot P38409 423
type: UnificationXref
id: P38409
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 32

uniprot P63044 212
type: UnificationXref
id: P63044
db: uniprot

uniprot F7BYI4 270
type: UnificationXref
id: F7BYI4
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot P13217 103
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 417
organism: Drosophila melanogaster

uniprot Q99JE6 152
type: UnificationXref
id: Q99JE6
db: uniprot

uniprot G3X7Z2 542
type: UnificationXref
id: G3X7Z2
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot P51432 113
xref: PTHR10336:SF11
organism: Mus musculus

uniprot F7AQR3 371
type: UnificationXref
id: F7AQR3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 382
organism: Macaca mulatta

Phosphoinositide phospholipase C 3
type: ProteinReference
xref: uniprot Q56W08 128
organism: Arabidopsis thaliana

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 489
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6ZKL2 79
xref: PTHR10336:SF12
organism: Macaca mulatta

uniprot E1BW98 339
type: UnificationXref
id: E1BW98
db: uniprot

G protein subunit alpha q
type: ProteinReference
xref: uniprot E1BA29 338
xref: PTHR10218:SF316
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot A0A1D5QG31 322
organism: Macaca mulatta

uniprot H2R3A6 399
type: UnificationXref
id: H2R3A6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 344
organism: Canis lupus familiaris

uniprot Q99P84 153
type: UnificationXref
id: Q99P84
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
type: ProteinReference
xref: uniprot Q62711 131
xref: PTHR10336:SF31
organism: Rattus norvegicus

uniprot F6TQN3 74
type: UnificationXref
id: F6TQN3
db: uniprot

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q9SD96 240
type: UnificationXref
id: Q9SD96
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot A0A3Q1MRR6 249
organism: Bos taurus

uniprot B3DJU0 499
type: UnificationXref
id: B3DJU0
db: uniprot

uniprot A0A2I3TBK2 521
type: UnificationXref
id: A0A2I3TBK2
db: uniprot

uniprot A0A1D5QIS2 165
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

Synaptobrevin
type: ProteinReference
xref: uniprot P18489 199
xref: PTHR45701:SF10
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR45628:SF7
xref: uniprot A0A3B1E663 524
organism: Caenorhabditis elegans

uniprot A0A3Q1LYB4 168
type: UnificationXref
id: A0A3Q1LYB4
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

uniprot A0A2J8QDF6 46
type: UnificationXref
id: A0A2J8QDF6
db: uniprot

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 240
organism: Arabidopsis thaliana

uniprot Q7QCP8 316
type: UnificationXref
id: Q7QCP8
db: uniprot

Glycoprotein hormones alpha chain
type: ProteinReference
xref: PTHR11509:SF0
xref: uniprot Q6YNX4 516
organism: Monodelphis domestica

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 466

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 331

uniprot P34722 296
type: UnificationXref
id: P34722
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 410
organism: Caenorhabditis elegans

uniprot O14775 405
type: UnificationXref
id: O14775
db: uniprot

ncbitaxon 13616 18
type: UnificationXref
id: 13616
db: ncbitaxon

Protein kinase C iota type
type: ProteinReference
xref: uniprot Q90XF2 320
xref: PTHR24356:SF214
organism: Danio rerio

uniprot Q61290 561
type: UnificationXref
id: Q61290
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot F6VT32 266
organism: Xenopus tropicalis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 460
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6SD46 71
xref: PTHR10336:SF12
organism: Monodelphis domestica

uniprot F7G7I9 387
type: UnificationXref
id: F7G7I9
db: uniprot

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5TZ66 226
organism: Danio rerio

uniprot P63214 446
type: UnificationXref
id: P63214
db: uniprot

uniprot F6XMN6 267
type: UnificationXref
id: F6XMN6
db: uniprot

TRHR isoform 1
type: ProteinReference
xref: PTHR46061:SF2
xref: uniprot A0A2J8PN27 9
organism: Pan troglodytes

uniprot Q5F3B5 464
type: UnificationXref
id: Q5F3B5
db: uniprot

SNARE COMPLEX s21 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SNARE COMPLEX
stoichiometric coefficient: 1.0

uniprot A0A2J8N6N1 523
type: UnificationXref
id: A0A2J8N6N1
db: uniprot

uniprot P30677 420
type: UnificationXref
id: P30677
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A5PEW5 169
xref: PTHR19305:SF14
organism: Caenorhabditis elegans

uniprot A0A2I3TDB2 522
type: UnificationXref
id: A0A2I3TDB2
db: uniprot

ncbitaxon 6238 12
type: UnificationXref
id: 6238
db: ncbitaxon

Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
type: ProteinReference
xref: uniprot F6THW2 362
xref: PTHR10218:SF328
organism: Xenopus tropicalis

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 336

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6SSS3 360
organism: Monodelphis domestica

uniprot E1BWA3 256
type: UnificationXref
id: E1BWA3
db: uniprot

uniprot Q7Q6D2 483
type: UnificationXref
id: Q7Q6D2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 394
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 365
organism: Macaca mulatta

eco ECO:0000305 557
type: UnificationXref
id: ECO:0000305
db: eco

uniprot P83099 302
type: UnificationXref
id: P83099
db: uniprot

uniprot F1MY82 261
type: UnificationXref
id: F1MY82
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re4
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 605
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 604
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

uniprot B8JLJ7 334
type: UnificationXref
id: B8JLJ7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 431
organism: Rattus norvegicus

uniprot Q9BV40 235
type: UnificationXref
id: Q9BV40
db: uniprot

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 163
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 214684 466
type: UnificationXref
id: 214684
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q91UZ1 149
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot Q8K4S1 147
organism: Mus musculus

TRH Receptor s43 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRH Receptor
stoichiometric coefficient: 1.0

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot F6UBJ8 176
organism: Xenopus tropicalis

Synaptobrevin homolog 2
type: ProteinReference
xref: uniprot P33328 202
organism: Saccharomyces cerevisiae

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9Z1B3 162
xref: PTHR10336:SF12
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot G5EFI8 85
organism: Caenorhabditis elegans

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot Q00722 114
organism: Homo sapiens

uniprot F6X115 15
type: UnificationXref
id: F6X115
db: uniprot

uniprot Q9CXP8 489
type: UnificationXref
id: Q9CXP8
db: uniprot

ProTRH (Pro Thyrotropin-releasing Hormone)
type: ProteinReference
xref: P04586
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Thyrotropin-releasing hormone receptor signaling pathway.PROTEIN.GENERIC.ProTRH (Pro Thyrotropin-releasing Hormone)
comment: ENTITY_REFERENCE_NOTES= Long Name: ProTRH (Pro Thyrotropin-releasing Hormone) Synonym: Pro Thyrotropin-releasing Hormone Accession: P04586
member entity reference: Thyroid stimulating hormone, beta subunit
member entity reference: Glycoprotein hormones alpha chain
member entity reference: Thyrotropin subunit beta
member entity reference: Thyroid stimulating hormone beta subunit
member entity reference: Pro-thyrotropin-releasing hormone
member entity reference: TSHB isoform 1

Phosphoinositide phospholipase C 5
type: ProteinReference
xref: uniprot Q944C2 151
organism: Arabidopsis thaliana

uniprot A0A1D5QLW6 38
type: UnificationXref
id: A0A1D5QLW6
db: uniprot

uniprot K7E376 403
type: UnificationXref
id: K7E376
db: uniprot

Syntaxin-3
type: ProteinReference
xref: uniprot Q13277 217
xref: PTHR19957:SF34
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot F7G1K7 384
organism: Monodelphis domestica

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F1M7Y5 259
organism: Rattus norvegicus

uniprot Q6NMA7 132
type: UnificationXref
id: Q6NMA7
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 18

uniprot F6XHP0 366
type: UnificationXref
id: F6XHP0
db: uniprot

uniprot Q56W08 128
type: UnificationXref
id: Q56W08
db: uniprot

uniprot P18489 199
type: UnificationXref
id: P18489
db: uniprot

uniprot Q62361 514
type: UnificationXref
id: Q62361
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 402
organism: Pan troglodytes

uniprot A0A2I3TRC4 323
type: UnificationXref
id: A0A2I3TRC4
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F1NG47 262
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 339
organism: Gallus gallus

uniprot P11962 511
type: UnificationXref
id: P11962
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F7BIC2 269
organism: Macaca mulatta

uniprot A4IFL6 327
type: UnificationXref
id: A4IFL6
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6VUT7 179
xref: PTHR19305:SF5
organism: Ornithorhynchus anatinus

UNKNOWN_TRANSITION_LEFT__ProTRH__Pro_Thyrotropin_releasing_Hormone_-RIGHT__TRH-_re9
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 601
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 600
left: ProTRH (Pro Thyrotropin-releasing Hormone)
interaction type: UNKNOWN_TRANSITION
right: TRH

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: uniprot O55017 548
xref: PTHR45628:SF6
organism: Mus musculus

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O00161 192
organism: Homo sapiens

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot E2RGU7 257
organism: Canis lupus familiaris

uniprot P63219 451
type: UnificationXref
id: P63219
db: uniprot

uniprot Q9BRC7 154
type: UnificationXref
id: Q9BRC7
db: uniprot

uniprot Q05513 308
type: UnificationXref
id: Q05513
db: uniprot

Phosphoinositide phospholipase C 4
type: ProteinReference
xref: uniprot Q944C1 150
organism: Arabidopsis thaliana

uniprot Q6PC54 230
type: UnificationXref
id: Q6PC54
db: uniprot

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05129 282
organism: Homo sapiens

CACNB4 isoform 1
type: ProteinReference
xref: uniprot H2RC03 544
organism: Pan troglodytes

ProTRH (Pro Thyrotropin-releasing Hormone)
type: Protein
entity reference: ProTRH (Pro Thyrotropin-releasing Hormone)
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05126 280
xref: PTHR24356:SF158
organism: Bos taurus

Thyrotropin subunit beta
type: ProteinReference
xref: PTHR11515:SF5
xref: uniprot F6V646 568
organism: Monodelphis domestica

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05128 281
organism: Bos taurus

uniprot K7BA21 94
type: UnificationXref
id: K7BA21
db: uniprot

uniprot Q02111 304
type: UnificationXref
id: Q02111
db: uniprot

uniprot A1L271 326
type: UnificationXref
id: A1L271
db: uniprot

uniprot F7ECA6 379
type: UnificationXref
id: F7ECA6
db: uniprot

PLC
type: ProteinReference
xref: P04581
standard name: Phospholipase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Thyrotropin-releasing hormone receptor signaling pathway.PROTEIN.GENERIC.PLC
comment: ENTITY_REFERENCE_NOTES= Long Name: PLC Synonym: Synonym not specified Accession: P04581
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
member entity reference: Phosphoinositide phospholipase C
member entity reference: Phosphoinositide phospholipase C 5
member entity reference: Inactive phospholipase C-like protein 2
member entity reference: Inactive phospholipase C-like protein 1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
member entity reference: Phosphoinositide phospholipase C 3
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
member entity reference: Phosphoinositide phospholipase C 7
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
member entity reference: Phosphoinositide phospholipase C 2
member entity reference: Phosphoinositide phospholipase C 1
member entity reference: Phosphoinositide phospholipase C 9
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
member entity reference: Phosphoinositide phospholipase C (Fragment)
member entity reference: Uncharacterized protein
member entity reference: Phosphoinositide phospholipase C 4
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 386
organism: Monodelphis domestica

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot G5EBH0 84
organism: Caenorhabditis elegans

Protein CBR-NMUR-4
type: ProteinReference
xref: uniprot A8WVT3 11
organism: Caenorhabditis briggsae

Vesicle associated membrane protein 1
type: ProteinReference
xref: uniprot F1PRG8 173
xref: PTHR45701:SF1
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re10 599
type: Stoichiometry
physical entity: TRH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 598
type: Stoichiometry
physical entity: TRH
stoichiometric coefficient: 1.0

ncbitaxon 9031 6
type: UnificationXref
id: 9031
db: ncbitaxon

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 292
organism: Mus musculus

Glycoprotein hormones alpha chain
type: ProteinReference
xref: PTHR11509:SF0
xref: uniprot P01215 505
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_re1
controller: PLC

Glycoprotein hormones alpha chain
type: ProteinReference
xref: PTHR11509:SF0
xref: uniprot P01216 506
organism: Mus musculus

uniprot Q9XWB7 161
type: UnificationXref
id: Q9XWB7
db: uniprot

uniprot F6YMH2 181
type: UnificationXref
id: F6YMH2
db: uniprot

PARTICIPANT STOICHIOMETRY re4 604
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9ERB0 236
xref: PTHR19305:SF9
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 474
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY re4 605
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot Q7Q042 315
type: UnificationXref
id: Q7Q042
db: uniprot

uniprot F7G3J2 386
type: UnificationXref
id: F7G3J2
db: uniprot

Protein kinase C, brain isozyme
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P05130 283
organism: Drosophila melanogaster

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot H2QKD0 88
organism: Pan troglodytes

PTHR11824:SF9
type: RelationshipXref
id: PTHR11824:SF9
db: PANTHER Family
relationship type: By Homology

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: uniprot Q8R3Z5 564
xref: PTHR11824:SF17
organism: Mus musculus

uniprot R4GKD1 496
type: UnificationXref
id: R4GKD1
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa7 580
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 491
organism: Homo sapiens

Phosphoinositide phospholipase C (Fragment)
type: ProteinReference
xref: uniprot Q7PW25 135
organism: Anopheles gambiae

uniprot Q92356 234
type: UnificationXref
id: Q92356
db: uniprot

uniprot P10894 101
type: UnificationXref
id: P10894
db: uniprot

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot P38408 422
organism: Bos taurus

uniprot Q8R0S4 563
type: UnificationXref
id: Q8R0S4
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P38409 423
xref: PTHR10218:SF328
organism: Bos taurus

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot H9ERR5 90
organism: Macaca mulatta

ncbitaxon 10090 26
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot P13677 288
type: UnificationXref
id: P13677
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 453
organism: Schizosaccharomyces pombe

ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
type: ProteinReference
xref: PTHR10336:SF29
xref: uniprot Q86YW0 140
organism: Homo sapiens

uniprot P63027 211
type: UnificationXref
id: P63027
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q8IA75 142
organism: Caenorhabditis elegans

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
type: ProteinReference
xref: uniprot P40977 110
organism: Schizosaccharomyces pombe

uniprot Q61016 471
type: UnificationXref
id: Q61016
db: uniprot

uniprot P50150 427
type: UnificationXref
id: P50150
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 346
organism: Canis lupus familiaris

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 124

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A2I3T8F7 45
xref: PTHR10336:SF11
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F5HMB9 69
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY re15 614
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 411
organism: Saccharomyces cerevisiae

uniprot H2QLA1 189
type: UnificationXref
id: H2QLA1
db: uniprot

PARTICIPANT STOICHIOMETRY re15 615
type: Stoichiometry
physical entity: Complex (SNARE COMPLEX/Ca2+)
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 479
organism: Danio rerio

uniprot F6THW2 362
type: UnificationXref
id: F6THW2
db: uniprot

uniprot Q02956 306
type: UnificationXref
id: Q02956
db: uniprot

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 495
organism: Drosophila melanogaster

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q17QQ3 219
type: UnificationXref
id: Q17QQ3
db: uniprot

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 393
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 355
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q99JE6 152
xref: PTHR10336:SF11
organism: Rattus norvegicus

uniprot A0A1D5R8E9 40
type: UnificationXref
id: A0A1D5R8E9
db: uniprot

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

uniprot P62881 441
type: UnificationXref
id: P62881
db: uniprot

Thyrotropin-releasing hormone receptor 3
type: ProteinReference
xref: uniprot F7C4A2 19
organism: Xenopus tropicalis

uniprot P13217 103
type: UnificationXref
id: P13217
db: uniprot

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

uniprot Q9R297 34
type: UnificationXref
id: Q9R297
db: uniprot

PARTICIPANT STOICHIOMETRY re15 613
type: Stoichiometry
physical entity: SNARE COMPLEX
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 494
organism: Homo sapiens

uniprot Q7Q6D4 485
type: UnificationXref
id: Q7Q6D4
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P29992 418
organism: Homo sapiens

uniprot P01215 505
type: UnificationXref
id: P01215
db: uniprot

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot Q00975 554
organism: Homo sapiens

uniprot P28867 295
type: UnificationXref
id: P28867
db: uniprot

Glycoprotein hormones alpha chain
type: ProteinReference
xref: PTHR11509:SF0
xref: uniprot P01217 507
organism: Bos taurus

uniprot F6SED9 175
type: UnificationXref
id: F6SED9
db: uniprot

uniprot Q5EAP4 463
type: UnificationXref
id: Q5EAP4
db: uniprot

G protein subunit alpha q
type: ProteinReference
xref: uniprot K6ZCJ5 401
xref: PTHR10218:SF316
organism: Pan troglodytes

Danio rerio
type: BioSource
xref: ncbitaxon 7955 67

uniprot P63319 300
type: UnificationXref
id: P63319
db: uniprot

uniprot Q5RKP9 467
type: UnificationXref
id: Q5RKP9
db: uniprot

uniprot F6XPD5 539
type: UnificationXref
id: F6XPD5
db: uniprot

uniprot F1MKT3 58
type: UnificationXref
id: F1MKT3
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1MLS3 59
organism: Bos taurus

uniprot A0A2I3T8F7 45
type: UnificationXref
id: A0A2I3T8F7
db: uniprot

Thyrotropin subunit beta
type: ProteinReference
xref: uniprot P01222 508
xref: PTHR11515:SF5
organism: Homo sapiens

Protein kinase C, eye isozyme
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P13677 288
organism: Drosophila melanogaster

Thyrotropin subunit beta
type: ProteinReference
xref: PTHR11515:SF5
xref: uniprot P01223 509
organism: Bos taurus

Phosphoinositide phospholipase C 1
type: ProteinReference
xref: uniprot Q39032 123
organism: Arabidopsis thaliana

Syntaxin-3
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q08849 215
organism: Rattus norvegicus

uniprot P90980 303
type: UnificationXref
id: P90980
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: uniprot Q7SY24 317
xref: PTHR24356:SF158
organism: Danio rerio

uniprot F7B1S0 540
type: UnificationXref
id: F7B1S0
db: uniprot

Phosphoinositide phospholipase C 2
type: ProteinReference
xref: uniprot Q39033 125
organism: Arabidopsis thaliana

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot P13678 289
organism: Drosophila melanogaster

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 324
organism: Pan troglodytes

ACTIVE 163
type: EntityFeature
comment: Active state

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F1NU41 354
organism: Gallus gallus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q17QQ3 219
xref: PTHR19305:SF5
organism: Bos taurus

Guanine nucleotide binding protein, q polypeptide
type: ProteinReference
xref: PTHR10218:SF329
xref: uniprot E9GJ31 349
organism: Daphnia pulex

uniprot Q6TH03 481
type: UnificationXref
id: Q6TH03
db: uniprot

PIP2
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

DISSOCIATION_LEFT__GTP-_Complex__GDP_G_Protein__TRH_Receptor_TRH_-RIGHT__Complex__GTP_G_Protein_-_GDP-_Complex__TRH_Receptor_TRH_-_re12
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 622
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 619
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 620
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 618
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 621
left: GTP
left: Complex (GDP/G-Protein/ TRH Receptor/TRH)
interaction type: DISSOCIATION
right: Complex (TRH Receptor/TRH)
right: Complex (GTP/G-Protein)
right: GDP

uniprot P10688 100
type: UnificationXref
id: P10688
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q9N0Y0 238
xref: PTHR45701:SF5
organism: Macaca mulatta

uniprot A5PKD6 329
type: UnificationXref
id: A5PKD6
db: uniprot

uniprot Q9HAV0 491
type: UnificationXref
id: Q9HAV0
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F1MDC9 260
xref: PTHR24351:SF182
organism: Bos taurus

Phosphoinositide phospholipase C 9
type: ProteinReference
xref: uniprot Q6NMA7 132
organism: Arabidopsis thaliana

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot P36975 203
organism: Drosophila melanogaster

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q3T0Y8 222
organism: Bos taurus

uniprot O95837 407
type: UnificationXref
id: O95837
db: uniprot

uniprot P25455 107
type: UnificationXref
id: P25455
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 369
organism: Monodelphis domestica

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A2I3RKF6 41
organism: Pan troglodytes

uniprot F1M7Y5 259
type: UnificationXref
id: F1M7Y5
db: uniprot

PTHR10037:SF290
type: RelationshipXref
id: PTHR10037:SF290
db: PANTHER Family
relationship type: By Homology

uniprot P63318 299
type: UnificationXref
id: P63318
db: uniprot

uniprot F6TAH0 73
type: UnificationXref
id: F6TAH0
db: uniprot

uniprot A0A2I3TIH6 497
type: UnificationXref
id: A0A2I3TIH6
db: uniprot

uniprot F7BVQ1 80
type: UnificationXref
id: F7BVQ1
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q15836 218
organism: Homo sapiens

uniprot Q20636 455
type: UnificationXref
id: Q20636
db: uniprot

Calcium channel, voltage-dependent, beta 4 subunit
type: ProteinReference
xref: uniprot F6TKH3 537
organism: Xenopus tropicalis

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re3
controller: PKC

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
type: ProteinReference
xref: uniprot Q9BRC7 154
xref: PTHR10336:SF31
organism: Homo sapiens

PTHR11515:SF5
type: RelationshipXref
id: PTHR11515:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q3T0Y8 222
type: UnificationXref
id: Q3T0Y8
db: uniprot

uniprot Q6DH55 476
type: UnificationXref
id: Q6DH55
db: uniprot

uniprot Q21754 121
type: UnificationXref
id: Q21754
db: uniprot

STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 607
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 606
left: Ca2+ channel
interaction type: STATE_TRANSITION
right: Ca2+ channel

PKC
type: ProteinReference
xref: P04583
standard name: Protein kinase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: PKC Synonym: protein kinase C Accession: P04583
comment: ENTITY_REFERENCE_ID_DESC=Thyrotropin-releasing hormone receptor signaling pathway.PROTEIN.GENERIC.PKC
member entity reference: Protein kinase C iota type
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C, brain isozyme
member entity reference: Protein kinase C gamma type (Fragment)
member entity reference: Protein kinase C
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C eta type
member entity reference: Protein kinase C-like 1
member entity reference: Protein kinase C-like 1B
member entity reference: Protein kinase C theta type
member entity reference: Putative protein kinase C delta type homolog
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C, eye isozyme
member entity reference: Protein kinase C-like 2
member entity reference: Protein kinase C zeta type
member entity reference: Protein kinase C-like 3
member entity reference: Atypical protein kinase C

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q6PC54 230
organism: Danio rerio

uniprot F1PRG8 173
type: UnificationXref
id: F1PRG8
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q15147 119
organism: Homo sapiens

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot O44419 195
organism: Strongylocentrotus purpuratus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot F6XMN6 267
organism: Canis lupus familiaris

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 476
organism: Danio rerio

exocytic vesicle
type: CellularLocationVocabulary
xref: GO GO:0070382 3

Thyrotropin
type: Protein
entity reference: Thyrotropin
comment: SPECIES_TYPE=PROTEIN

PTHR17530:SF2
type: RelationshipXref
id: PTHR17530:SF2
db: PANTHER Family
relationship type: By Homology

uniprot P63078 443
type: UnificationXref
id: P63078
db: uniprot

uniprot F7E2P1 82
type: UnificationXref
id: F7E2P1
db: uniprot

PTHR46061:SF2
type: RelationshipXref
id: PTHR46061:SF2
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 361
organism: Macaca mulatta

uniprot Q5XGD8 468
type: UnificationXref
id: Q5XGD8
db: uniprot

uniprot Q8K3R3 145
type: UnificationXref
id: Q8K3R3
db: uniprot

Phosphoinositide phospholipase C 7
type: ProteinReference
xref: uniprot Q9LY51 155
organism: Arabidopsis thaliana

uniprot P54284 549
type: UnificationXref
id: P54284
db: uniprot

Inactive phospholipase C-like protein 1
type: ProteinReference
xref: uniprot Q15111 118
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot K7BA21 94
xref: PTHR10336:SF12
organism: Pan troglodytes

uniprot F1MYW8 352
type: UnificationXref
id: F1MYW8
db: uniprot

TRH
type: Protein
entity reference: TRH
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa11 572
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P63077 442
type: UnificationXref
id: P63077
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q62442 227
organism: Mus musculus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 30

GDP s12 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot H2QDQ1 277
type: UnificationXref
id: H2QDQ1
db: uniprot

PTHR10037:SF289
type: RelationshipXref
id: PTHR10037:SF289
db: PANTHER Family
relationship type: By Homology

uniprot P09216 286
type: UnificationXref
id: P09216
db: uniprot

uniprot K7C8Z4 95
type: UnificationXref
id: K7C8Z4
db: uniprot

PTHR10336:SF6
type: RelationshipXref
id: PTHR10336:SF6
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q05655 309
xref: PTHR24356:SF365
organism: Homo sapiens

uniprot P01222 508
type: UnificationXref
id: P01222
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 348

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
type: ProteinReference
xref: PTHR10336:SF33
xref: uniprot Q8K2J0 143
organism: Mus musculus

uniprot Q15111 118
type: UnificationXref
id: Q15111
db: uniprot

uniprot E2R2S8 342
type: UnificationXref
id: E2R2S8
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot E1BWA3 256
organism: Gallus gallus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 443
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 442
organism: Rattus norvegicus

uniprot P34885 297
type: UnificationXref
id: P34885
db: uniprot

uniprot Q08849 215
type: UnificationXref
id: Q08849
db: uniprot

uniprot F7CFG8 374
type: UnificationXref
id: F7CFG8
db: uniprot

uniprot A0A2I3RV12 42
type: UnificationXref
id: A0A2I3RV12
db: uniprot

uniprot Q2KJD2 221
type: UnificationXref
id: Q2KJD2
db: uniprot

uniprot Q15KE4 454
type: UnificationXref
id: Q15KE4
db: uniprot

uniprot F7DWM0 20
type: UnificationXref
id: F7DWM0
db: uniprot

LD03592p
type: ProteinReference
xref: uniprot Q9W1I8 242
xref: PTHR19305:SF9
organism: Drosophila melanogaster

uniprot H2QNC9 502
type: UnificationXref
id: H2QNC9
db: uniprot

uniprot F6SRP9 72
type: UnificationXref
id: F6SRP9
db: uniprot

uniprot O44419 195
type: UnificationXref
id: O44419
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 433
organism: Rattus norvegicus

TRH s20 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRH
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 432
organism: Rattus norvegicus

Thyroid stimulating hormone beta subunit
type: ProteinReference
xref: PTHR11515:SF5
xref: uniprot F6RBM2 500
organism: Macaca mulatta

uniprot P62873 437
type: UnificationXref
id: P62873
db: uniprot

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 237
organism: Arabidopsis thaliana

Thyrotropin subunit beta
type: ProteinReference
xref: uniprot O57340 503
xref: PTHR11515:SF5
organism: Gallus gallus

uniprot Q9XSW8 517
type: UnificationXref
id: Q9XSW8
db: uniprot

uniprot P50148 426
type: UnificationXref
id: P50148
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot H9FVW1 91
xref: PTHR10336:SF106
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F1PS03 64
xref: PTHR10336:SF173
organism: Canis lupus familiaris

uniprot E2RGU7 257
type: UnificationXref
id: E2RGU7
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 377
organism: Ornithorhynchus anatinus

uniprot P68404 301
type: UnificationXref
id: P68404
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q0V7N0 216
organism: Bos taurus

Parvocellular cells in Paraventricular Nucleus of Hypothalamus release of TRH from Median Eminence c5
type: CellularLocationVocabulary
comment: Parvocellular cells in Paraventricular Nucleus of Hypothalamus (release of TRH from Median Eminence)

uniprot F7GU82 83
type: UnificationXref
id: F7GU82
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3RQJ8 246
xref: PTHR24356:SF214
organism: Pan troglodytes

Thyroid hormone release
type: Pathway

uniprot F7DVL1 271
type: UnificationXref
id: F7DVL1
db: uniprot

uniprot P05771 284
type: UnificationXref
id: P05771
db: uniprot

PTHR11509:SF0
type: RelationshipXref
id: PTHR11509:SF0
db: PANTHER Family
relationship type: By Homology

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot Q5EAP4 463
organism: Rattus norvegicus

uniprot Q0VFC4 452
type: UnificationXref
id: Q0VFC4
db: uniprot

uniprot F1PL99 62
type: UnificationXref
id: F1PL99
db: uniprot

uniprot F1MDC9 260
type: UnificationXref
id: F1MDC9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 480
organism: Danio rerio

uniprot Q39032 123
type: UnificationXref
id: Q39032
db: uniprot

Complex (GDP/G-Protein/ TRH Receptor)
type: Complex
component stoichiometry: G Protein s8 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s44 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRH Receptor s43 sa5 STOICHIOMETRY ID COMPLEX
component: G-Protein
component: TRH Receptor
component: GDP
feature: COMPLEX BINDING FEATURE s24 a37 589
feature: COMPLEX BINDING FEATURE s24 a37 585
feature: COMPLEX BINDING FEATURE s24 a37 587
cellular location: cytosol

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A1D5Q3D7 36
xref: PTHR10336:SF31
organism: Macaca mulatta

uniprot P05128 281
type: UnificationXref
id: P05128
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: uniprot A8KBH6 252
xref: PTHR24356:SF158
organism: Xenopus tropicalis

Thyrotropin-releasing hormone receptor
type: ProteinReference
xref: uniprot P21761 25
xref: PTHR46061:SF2
organism: Mus musculus

uniprot Q9P212 157
type: UnificationXref
id: Q9P212
db: uniprot

uniprot G5EGU1 392
type: UnificationXref
id: G5EGU1
db: uniprot

G protein alpha q subunit
type: ProteinReference
xref: PTHR10218:SF329
xref: uniprot P23625 414
organism: Drosophila melanogaster

uniprot Q61011 470
type: UnificationXref
id: Q61011
db: uniprot

uniprot F6SWI4 536
type: UnificationXref
id: F6SWI4
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 351

Voltage-dependent R-type calcium channel subunit alpha-1E
type: ProteinReference
xref: uniprot Q61290 561
xref: PTHR45628:SF5
organism: Mus musculus

uniprot Q91UZ1 149
type: UnificationXref
id: Q91UZ1
db: uniprot

TRH
type: Protein
entity reference: TRH
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q7SBR2 137
type: UnificationXref
id: Q7SBR2
db: uniprot

PARTICIPANT STOICHIOMETRY re12 622
type: Stoichiometry
physical entity: Complex (TRH Receptor/TRH)
stoichiometric coefficient: 1.0

uniprot Q9ERT2 33
type: UnificationXref
id: Q9ERT2
db: uniprot

PARTICIPANT STOICHIOMETRY re12 620
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

PTHR19957:SF34
type: RelationshipXref
id: PTHR19957:SF34
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re12 621
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q9XWB7 161
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot A0A1D5QIS2 165
organism: Macaca mulatta

uniprot A0A3Q1NGS8 325
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

PLC
type: Protein
entity reference: PLC
feature: ACTIVE 163
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9913 24
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot Q9VXH3 160
type: UnificationXref
id: Q9VXH3
db: uniprot

uniprot K7CBH8 279
type: UnificationXref
id: K7CBH8
db: uniprot

uniprot F5HMS4 174
type: UnificationXref
id: F5HMS4
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7BYI4 270
xref: PTHR24356:SF158
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: uniprot Q7QCP8 316
xref: PTHR24356:SF240
organism: Anopheles gambiae

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot Q1RML2 120
type: UnificationXref
id: Q1RML2
db: uniprot

uniprot F1PLB3 63
type: UnificationXref
id: F1PLB3
db: uniprot

Voltage-dependent R-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot A0A1D5Q7C3 519
xref: PTHR45628:SF5
organism: Macaca mulatta

STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 603
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 602
left: PLC
interaction type: STATE_TRANSITION
right: PLC

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot H2Q995 188
organism: Pan troglodytes

Ca2+ channel
type: Protein
entity reference: Ca2+ channel
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P18851 411
type: UnificationXref
id: P18851
db: uniprot

Thyrotropin-Releasing Hormone Receptor
type: ProteinReference
xref: uniprot Q95YD7 31
organism: Caenorhabditis elegans

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot H2QJY5 87
xref: PTHR10336:SF106
organism: Pan troglodytes

GDP s44 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot E2RT75 56
organism: Canis lupus familiaris

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__TRH-RIGHT__TRH-_re10
control type: ACTIVATION
controller: SNARE COMPLEX

PARTICIPANT STOICHIOMETRY re12 618
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 378
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY re12 619
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/ TRH Receptor/TRH)
stoichiometric coefficient: 1.0

PLC
type: Protein
entity reference: PLC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot B7Q3T6 332
type: UnificationXref
id: B7Q3T6
db: uniprot

uniprot A0A2I3TUD1 324
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

Calcium Channel, Beta subunit
type: ProteinReference
xref: uniprot A0A078BQJ0 518
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 434
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 409
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 363
organism: Ornithorhynchus anatinus

uniprot Q944C2 151
type: UnificationXref
id: Q944C2
db: uniprot

uniprot H9EU39 278
type: UnificationXref
id: H9EU39
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 224

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 478
organism: Danio rerio

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9NQ66 156
xref: PTHR10336:SF12
organism: Homo sapiens

uniprot Q6Z3Y9 133
type: UnificationXref
id: Q6Z3Y9
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 475
organism: Danio rerio

uniprot E1C795 340
type: UnificationXref
id: E1C795
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 400
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A1D5R8E9 40
xref: PTHR10336:SF173
organism: Macaca mulatta

Calcium Channel, Beta subunit
type: ProteinReference
xref: uniprot O01661 547
organism: Caenorhabditis elegans

uniprot Q9MZL5 566
type: UnificationXref
id: Q9MZL5
db: uniprot

uniprot P63045 213
type: UnificationXref
id: P63045
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot A8XRA5 51
organism: Caenorhabditis briggsae

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot A0A2I3SR99 167
xref: PTHR45701:SF7
organism: Pan troglodytes

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot E1BH60 54
organism: Bos taurus

uniprot Q9WTQ0 321
type: UnificationXref
id: Q9WTQ0
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot A0A1D5QYR9 166
organism: Macaca mulatta

uniprot P51178 112
type: UnificationXref
id: P51178
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F6TAH0 73
organism: Monodelphis domestica

uniprot E2RT75 56
type: UnificationXref
id: E2RT75
db: uniprot

Inactive phospholipase C-like protein 1
type: ProteinReference
xref: uniprot Q62688 130
organism: Rattus norvegicus

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A2I3RVP2 43
xref: PTHR10336:SF29
organism: Pan troglodytes

uniprot Q5PU49 312
type: UnificationXref
id: Q5PU49
db: uniprot

uniprot P21761 25
type: UnificationXref
id: P21761
db: uniprot

uniprot O95721 198
type: UnificationXref
id: O95721
db: uniprot

ncbitaxon 7165 70
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot Q9UK08 494
type: UnificationXref
id: Q9UK08
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F6TQN3 74
organism: Monodelphis domestica

uniprot F6TFY2 361
type: UnificationXref
id: F6TFY2
db: uniprot

uniprot O14610 404
type: UnificationXref
id: O14610
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A3Q1MMD9 47
xref: PTHR10336:SF25
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 383
organism: Macaca mulatta

uniprot Q86YW0 140
type: UnificationXref
id: Q86YW0
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 416
organism: Mus musculus

uniprot F7A632 268
type: UnificationXref
id: F7A632
db: uniprot

ncbitaxon 10116 30
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot Q8R3B1 148
type: UnificationXref
id: Q8R3B1
db: uniprot

Thyrotropin-releasing hormone receptor
type: ProteinReference
xref: uniprot F6X115 15
xref: PTHR46061:SF2
organism: Xenopus tropicalis

Phosphoinositide phospholipase C (Fragment)
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F1QLX2 66
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 398
organism: Pan troglodytes

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F5HMS4 174
xref: PTHR19305:SF14
organism: Anopheles gambiae

uniprot A7EDU2 330
type: UnificationXref
id: A7EDU2
db: uniprot

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 462
organism: Danio rerio

uniprot Q8K4S1 147
type: UnificationXref
id: Q8K4S1
db: uniprot

uniprot F1PS03 64
type: UnificationXref
id: F1PS03
db: uniprot

uniprot K7AE17 402
type: UnificationXref
id: K7AE17
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 109

uniprot H2RB55 89
type: UnificationXref
id: H2RB55
db: uniprot

uniprot P62872 436
type: UnificationXref
id: P62872
db: uniprot

uniprot F1R506 264
type: UnificationXref
id: F1R506
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 104

G-Protein
type: ProteinReference
xref: P04584
comment: ENTITY_REFERENCE_ID_DESC=Thyrotropin-releasing hormone receptor signaling pathway.PROTEIN.GENERIC.G-Protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein G(q) subunit alpha
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Gnb2 protein
member entity reference: Guanine nucleotide-binding protein subunit beta-5a
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
member entity reference: G protein subunit beta 1
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 14
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: G protein subunit alpha 14
member entity reference: G protein alpha q subunit
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Guanine nucleotide-binding protein subunit alpha-14
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: Guanine nucleotide binding protein, beta 3
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
member entity reference: AGAP005912-PA
member entity reference: G protein subunit gamma 5
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: GNB4 protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: Gnb3 protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein (G protein), q polypeptide
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: G protein subunit beta 3
member entity reference: Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
member entity reference: AGAP005911-PA
member entity reference: G-protein beta subunit
member entity reference: G protein subunit alpha q

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 470
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot H2Q3R5 187
organism: Pan troglodytes

uniprot F1QLX2 66
type: UnificationXref
id: F1QLX2
db: uniprot

uniprot Q7SZZ5 232
type: UnificationXref
id: Q7SZZ5
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: uniprot Q02956 306
xref: PTHR24356:SF170
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
type: ProteinReference
xref: uniprot Q22070 122
organism: Caenorhabditis elegans

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1P354 60
organism: Gallus gallus

uniprot Q8IA75 142
type: UnificationXref
id: Q8IA75
db: uniprot

DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_re1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 610
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 612
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 611
left: PIP2
interaction type: DISSOCIATION
right: DAG
right: IP3

PTHR11824:SF17
type: RelationshipXref
id: PTHR11824:SF17
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot H9ZA60 92
organism: Macaca mulatta

SNARE COMPLEX
type: ProteinReference
xref: P04582
standard name: SNARE Complex
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: SNARE COMPLEX Synonym: Synonym not specified Accession: P04582
comment: ENTITY_REFERENCE_ID_DESC=Thyrotropin-releasing hormone receptor signaling pathway.PROTEIN.GENERIC.SNARE COMPLEX
member entity reference: Synaptosomal-associated protein 25
member entity reference: Vesicle-associated membrane protein 2
member entity reference: Synaptosomal-associated protein 29
member entity reference: SNAP29 isoform 1
member entity reference: VAMP2 isoform 3
member entity reference: Synaptosomal-associated protein
member entity reference: Uncharacterized protein
member entity reference: Vesicle-associated membrane protein 3
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: Soluble NSF attachment protein 29
member entity reference: Syntaxin-3
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Synaptosomal-associated protein 23
member entity reference: Neuronal synaptobrevin, isoform J
member entity reference: Synaptobrevin-1
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: Putative SNAP25 homologous protein SNAP30
member entity reference: Syntaxin 3A
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Syntaxin 3
member entity reference: Vesicle associated membrane protein 1
member entity reference: Vesicle-associated membrane protein 8 (Endobrevin)
member entity reference: Synaptosomal-associated protein 25-A
member entity reference: Synaptobrevin homolog 2
member entity reference: SNAP25 homologous protein SNAP33
member entity reference: t-SNARE protein aex-4
member entity reference: Synaptobrevin
member entity reference: Vesicle associated membrane protein 8
member entity reference: VAMP3 isoform 1
member entity reference: Synaptosomal-associated protein 25-B

Protein kinase C
type: ProteinReference
xref: uniprot F1R506 264
xref: PTHR24356:SF181
organism: Danio rerio

PTHR10218:SF213
type: RelationshipXref
id: PTHR10218:SF213
db: PANTHER Family
relationship type: By Homology

uniprot A3KGF7 49
type: UnificationXref
id: A3KGF7
db: uniprot

uniprot Q9S7P9 239
type: UnificationXref
id: Q9S7P9
db: uniprot

uniprot F6V646 568
type: UnificationXref
id: F6V646
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot Q64617 314
organism: Rattus norvegicus

G Protein s4 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot Q5BH99 461
type: UnificationXref
id: Q5BH99
db: uniprot

ncbitaxon 5786 351
type: UnificationXref
id: 5786
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
type: ProteinReference
xref: PTHR10336:SF29
xref: uniprot Q8K4D7 146
organism: Mus musculus

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63318 299
organism: Mus musculus

Voltage-dependent L-type calcium channel subunit beta-2
type: ProteinReference
xref: uniprot Q8CC27 562
xref: PTHR11824:SF9
organism: Mus musculus

ncbitaxon 8364 16
type: UnificationXref
id: 8364
db: ncbitaxon

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P63319 300
xref: PTHR24356:SF162
organism: Rattus norvegicus

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 482
organism: Anopheles gambiae

Guanine nucleotide-binding protein (G protein), alpha 14
type: ProteinReference
xref: uniprot Q66JF0 473
xref: PTHR10218:SF213
organism: Xenopus tropicalis

uniprot P59768 434
type: UnificationXref
id: P59768
db: uniprot

Protein kinase C-like 2
type: ProteinReference
xref: uniprot P90980 303
xref: PTHR24356:SF390
organism: Caenorhabditis elegans

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot E2RQM0 55
organism: Canis lupus familiaris

uniprot A8XTZ1 52
type: UnificationXref
id: A8XTZ1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 471
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 472
organism: Mus musculus

uniprot E1BH60 54
type: UnificationXref
id: E1BH60
db: uniprot

uniprot F6REU0 535
type: UnificationXref
id: F6REU0
db: uniprot

Glycoprotein hormones alpha chain
type: ProteinReference
xref: PTHR11509:SF0
xref: uniprot F6W2E6 501
organism: Xenopus tropicalis

TRH Receptor
type: Protein
entity reference: TRH Receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa5 590
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9Z2P6 244
organism: Rattus norvegicus

uniprot P83351 214
type: UnificationXref
id: P83351
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q9WUF4 243
organism: Rattus norvegicus

uniprot A0A096MJW8 35
type: UnificationXref
id: A0A096MJW8
db: uniprot

uniprot P24723 294
type: UnificationXref
id: P24723
db: uniprot

uniprot P08487 97
type: UnificationXref
id: P08487
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q5R1X1 225
xref: PTHR19305:SF5
organism: Pan troglodytes

uniprot Q5ASG1 223
type: UnificationXref
id: Q5ASG1
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re4
control type: ACTIVATION
controller: Ca2+ channel

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P23298 293
organism: Mus musculus

Voltage-dependent P/Q-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR10037:SF290
xref: uniprot F1N1E0 533
organism: Bos taurus

uniprot Q6PH57 480
type: UnificationXref
id: Q6PH57
db: uniprot

uniprot Q28HP6 220
type: UnificationXref
id: Q28HP6
db: uniprot

uniprot P34981 27
type: UnificationXref
id: P34981
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 16

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1PL99 62
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
type: ProteinReference
xref: PTHR10336:SF29
xref: uniprot Q1RML2 120
organism: Bos taurus

uniprot E9FUX0 347
type: UnificationXref
id: E9FUX0
db: uniprot

uniprot F7C4A2 19
type: UnificationXref
id: F7C4A2
db: uniprot

TSHB isoform 1
type: ProteinReference
xref: uniprot A0A2J8JRX0 498
xref: PTHR11515:SF5
organism: Pan troglodytes

uniprot E2R907 172
type: UnificationXref
id: E2R907
db: uniprot

uniprot H9ERR5 90
type: UnificationXref
id: H9ERR5
db: uniprot

uniprot A0A078BQJ0 518
type: UnificationXref
id: A0A078BQJ0
db: uniprot

Thyroid stimulating hormone, beta subunit
type: ProteinReference
xref: uniprot B3DJU0 499
xref: PTHR11515:SF5
organism: Danio rerio

TRIGGER
type: RelationshipTypeVocabulary

uniprot P20444 292
type: UnificationXref
id: P20444
db: uniprot

uniprot A8XRA5 51
type: UnificationXref
id: A8XRA5
db: uniprot

ncbitaxon 227321 224
type: UnificationXref
id: 227321
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q7QHE3 136
organism: Anopheles gambiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re6
controller: Complex (GTP/G-Protein)

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F1PL90 61
xref: PTHR10336:SF12
organism: Canis lupus familiaris

uniprot F1NU41 354
type: UnificationXref
id: F1NU41
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 404
organism: Homo sapiens

P04587
type: UnificationXref
id: P04587
db: PANTHER Pathway Component

uniprot Q8K394 144
type: UnificationXref
id: Q8K394
db: uniprot

P04588
type: UnificationXref
id: P04588
db: PANTHER Pathway Component

P04583
type: UnificationXref
id: P04583
db: PANTHER Pathway Component

Calcium voltage-gated channel auxiliary subunit beta 2
type: ProteinReference
xref: PTHR11824:SF9
xref: uniprot E2RCN6 531
organism: Canis lupus familiaris

P04584
type: UnificationXref
id: P04584
db: PANTHER Pathway Component

Protein CBR-CCB-2
type: ProteinReference
xref: uniprot A8WWH4 528
organism: Caenorhabditis briggsae

P04585
type: UnificationXref
id: P04585
db: PANTHER Pathway Component

uniprot P36975 203
type: UnificationXref
id: P36975
db: uniprot

P04586
type: UnificationXref
id: P04586
db: PANTHER Pathway Component

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 425
organism: Arabidopsis thaliana

P04580
type: UnificationXref
id: P04580
db: PANTHER Pathway Component

uniprot E2R9G5 343
type: UnificationXref
id: E2R9G5
db: uniprot

P04581
type: UnificationXref
id: P04581
db: PANTHER Pathway Component

uniprot F7ASR8 372
type: UnificationXref
id: F7ASR8
db: uniprot

P04582
type: UnificationXref
id: P04582
db: PANTHER Pathway Component

uniprot F6W2E6 501
type: UnificationXref
id: F6W2E6
db: uniprot

uniprot F6XYX9 180
type: UnificationXref
id: F6XYX9
db: uniprot

uniprot Q9W3J1 495
type: UnificationXref
id: Q9W3J1
db: uniprot

uniprot F5HKU8 534
type: UnificationXref
id: F5HKU8
db: uniprot

uniprot P51432 113
type: UnificationXref
id: P51432
db: uniprot

TRH Receptor
type: ProteinReference
xref: P04580
comment: ENTITY_REFERENCE_ID_DESC=Thyrotropin-releasing hormone receptor signaling pathway.PROTEIN.RECEPTOR.TRH Receptor
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Thyrotropin-releasing hormone receptor 2
member entity reference: Thyrotropin-releasing hormone receptor
member entity reference: Protein CBR-NMUR-4
member entity reference: TRHR isoform 1
member entity reference: Motilin receptor
member entity reference: Thyrotropin-Releasing Hormone Receptor
member entity reference: Thyrotropin-releasing hormone receptor 3
member entity reference: Uncharacterized protein
member entity reference: Thyrotropin releasing hormone receptor

uniprot P10687 99
type: UnificationXref
id: P10687
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 408
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: uniprot E1BMG4 254
xref: PTHR24356:SF181
organism: Bos taurus

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P24723 294
organism: Homo sapiens

uniprot F6VM87 178
type: UnificationXref
id: F6VM87
db: uniprot

Voltage-dependent R-type calcium channel subunit alpha-1E
type: ProteinReference
xref: uniprot Q15878 560
xref: PTHR45628:SF5
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 389
organism: Macaca mulatta

TRH s18 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRH
stoichiometric coefficient: 1.0

uniprot A0A2J8PN27 9
type: UnificationXref
id: A0A2J8PN27
db: uniprot

uniprot P16054 290
type: UnificationXref
id: P16054
db: uniprot

uniprot A0A1D5QDW1 164
type: UnificationXref
id: A0A1D5QDW1
db: uniprot

uniprot P62880 440
type: UnificationXref
id: P62880
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 4

uniprot O70404 197
type: UnificationXref
id: O70404
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot E2QUL2 171
organism: Canis lupus familiaris

uniprot P49177 425
type: UnificationXref
id: P49177
db: uniprot

uniprot Q7Q6D3 484
type: UnificationXref
id: Q7Q6D3
db: uniprot

Protein CBR-UNC-2 (Fragment)
type: ProteinReference
xref: PTHR45628:SF7
xref: uniprot A8WRW6 527
organism: Caenorhabditis briggsae

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 357
organism: Neurospora crassa

uniprot Q28FH0 457
type: UnificationXref
id: Q28FH0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 424
organism: Rattus norvegicus

uniprot Q62688 130
type: UnificationXref
id: Q62688
db: uniprot

uniprot Q15878 560
type: UnificationXref
id: Q15878
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 328
organism: Xenopus tropicalis

uniprot Q6PBY0 479
type: UnificationXref
id: Q6PBY0
db: uniprot

uniprot O02495 193
type: UnificationXref
id: O02495
db: uniprot

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: uniprot Q9MZL7 567
xref: PTHR11824:SF17
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot Q02158 116
organism: Dictyostelium discoideum

uniprot F1N167 532
type: UnificationXref
id: F1N167
db: uniprot

uniprot P60877 204
type: UnificationXref
id: P60877
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q02156 305
xref: PTHR24356:SF159
organism: Homo sapiens

uniprot Q8VGC3 565
type: UnificationXref
id: Q8VGC3
db: uniprot

Voltage-dependent L-type calcium channel subunit beta-2
type: ProteinReference
xref: uniprot Q9MZL5 566
xref: PTHR11824:SF9
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q28024 456
organism: Bos taurus

uniprot F7H6T7 389
type: UnificationXref
id: F7H6T7
db: uniprot

uniprot A0A2I3SHP7 44
type: UnificationXref
id: A0A2I3SHP7
db: uniprot

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 367
organism: Monodelphis domestica

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 574
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot E2RHY4 345
type: UnificationXref
id: E2RHY4
db: uniprot

uniprot Q7ZUC5 319
type: UnificationXref
id: Q7ZUC5
db: uniprot

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 234
organism: Schizosaccharomyces pombe

uniprot F7EG64 272
type: UnificationXref
id: F7EG64
db: uniprot

ncbitaxon 7955 67
type: UnificationXref
id: 7955
db: ncbitaxon

ncbitaxon 367110 138
type: UnificationXref
id: 367110
db: ncbitaxon

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 485
organism: Anopheles gambiae

Voltage-dependent R-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF5
xref: uniprot A0A2J8N6N1 523
organism: Pan troglodytes

uniprot F6Z5I2 182
type: UnificationXref
id: F6Z5I2
db: uniprot

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 483
organism: Anopheles gambiae

ncbitaxon 9606 28
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q9LMG8 237
type: UnificationXref
id: Q9LMG8
db: uniprot

PTHR24356:SF240
type: RelationshipXref
id: PTHR24356:SF240
db: PANTHER Family
relationship type: By Homology

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 484
organism: Anopheles gambiae

uniprot P01223 509
type: UnificationXref
id: P01223
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 24

uniprot Q01970 115
type: UnificationXref
id: Q01970
db: uniprot

UNKNOWN_TRANSITION
type: InteractionVocabulary

uniprot P23298 293
type: UnificationXref
id: P23298
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 76

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 395
organism: Pan troglodytes

uniprot H2Q9G5 396
type: UnificationXref
id: H2Q9G5
db: uniprot

uniprot F7FXA9 383
type: UnificationXref
id: F7FXA9
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: uniprot P10895 102
xref: PTHR10336:SF80
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot P10894 101
organism: Bos taurus

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa6 578
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A8WWH4 528
type: UnificationXref
id: A8WWH4
db: uniprot

uniprot Q6P025 477
type: UnificationXref
id: Q6P025
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot O89040 96
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F7BVQ1 80
xref: PTHR10336:SF25
organism: Monodelphis domestica

uniprot H2QJY5 87
type: UnificationXref
id: H2QJY5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 458
organism: Xenopus tropicalis

uniprot P63215 447
type: UnificationXref
id: P63215
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_Protein__TRH_Receptor_-_TRH-RIGHT__Complex__GDP_G_Protein__TRH_Receptor_TRH_-_re11
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 596
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 597
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 595
left: Complex (GDP/G-Protein/ TRH Receptor)
left: TRH
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-Protein/ TRH Receptor/TRH)

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 419
organism: Bos taurus

uniprot F6VUT7 179
type: UnificationXref
id: F6VUT7
db: uniprot

uniprot A1Z9X0 251
type: UnificationXref
id: A1Z9X0
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 333

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N167 532
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P08487 97
xref: PTHR10336:SF173
organism: Bos taurus

PTHR24356:SF214
type: RelationshipXref
id: PTHR24356:SF214
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3SR38 247
xref: PTHR24356:SF181
organism: Pan troglodytes

uniprot F7GI54 388
type: UnificationXref
id: F7GI54
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 350
organism: Dictyostelium purpureum

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 14

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q08BT6 310
xref: PTHR24356:SF159
organism: Xenopus tropicalis

Voltage-dependent R-type calcium channel subunit alpha-1E
type: ProteinReference
xref: PTHR45628:SF5
xref: uniprot Q07652 558
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 325
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 397
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 387
organism: Ornithorhynchus anatinus

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q7SE08 139
organism: Neurospora crassa

VAMP3 isoform 1
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot G2HIJ9 185
organism: Pan troglodytes

uniprot K6ZCJ5 401
type: UnificationXref
id: K6ZCJ5
db: uniprot

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

AGAP002578-PB
type: ProteinReference
xref: uniprot F5HKU8 534
xref: PTHR45628:SF7
organism: Anopheles gambiae

uniprot Q07652 558
type: UnificationXref
id: Q07652
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot E2R907 172
xref: PTHR19305:SF5
organism: Canis lupus familiaris

Voltage-dependent L-type calcium channel subunit beta-3
type: ProteinReference
xref: uniprot P54287 551
organism: Rattus norvegicus

Voltage-dependent L-type calcium channel subunit beta-3
type: ProteinReference
xref: uniprot P54284 549
organism: Homo sapiens

uniprot Q3SZ98 460
type: UnificationXref
id: Q3SZ98
db: uniprot

uniprot P50154 430
type: UnificationXref
id: P50154
db: uniprot

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot P30677 420
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 374
organism: Monodelphis domestica

Voltage-dependent L-type calcium channel subunit beta-3
type: ProteinReference
xref: uniprot P54285 550
organism: Mus musculus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 6

CACNB2 isoform 5
type: ProteinReference
xref: uniprot H2R368 543
xref: PTHR11824:SF9
organism: Pan troglodytes

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q02111 304
xref: PTHR24356:SF181
organism: Mus musculus

uniprot A0A2I3T217 520
type: UnificationXref
id: A0A2I3T217
db: uniprot

uniprot A0A2J8JRX0 498
type: UnificationXref
id: A0A2J8JRX0
db: uniprot

uniprot F1MLS3 59
type: UnificationXref
id: F1MLS3
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q5PU49 312
xref: PTHR24356:SF365
organism: Canis lupus familiaris

uniprot Q9Z2P6 244
type: UnificationXref
id: Q9Z2P6
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P21278 412
organism: Mus musculus

uniprot H2PZA6 393
type: UnificationXref
id: H2PZA6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 388
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ECA6 379
xref: PTHR10218:SF328
organism: Monodelphis domestica

uniprot F7AUF1 17
type: UnificationXref
id: F7AUF1
db: uniprot

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P21279 413
organism: Mus musculus

uniprot P60879 206
type: UnificationXref
id: P60879
db: uniprot

uniprot Q95YD7 31
type: UnificationXref
id: Q95YD7
db: uniprot

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 239
organism: Arabidopsis thaliana

uniprot Q5KI86 465
type: UnificationXref
id: Q5KI86
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q9VH76 241
xref: PTHR19305:SF14
organism: Drosophila melanogaster

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F1PLB3 63
organism: Canis lupus familiaris

uniprot P11017 408
type: UnificationXref
id: P11017
db: uniprot

Phosphoinositide phospholipase C 8
type: ProteinReference
xref: uniprot Q9STZ3 159
organism: Arabidopsis thaliana

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 477
organism: Danio rerio

uniprot F7ERM9 22
type: UnificationXref
id: F7ERM9
db: uniprot

uniprot F6ZC55 78
type: UnificationXref
id: F6ZC55
db: uniprot

uniprot A8WR64 253
type: UnificationXref
id: A8WR64
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: uniprot P68404 301
xref: PTHR24356:SF158
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 465
organism: Cryptococcus neoformans

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 347
organism: Daphnia pulex

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: PTHR10336:SF80
xref: uniprot P51178 112
organism: Homo sapiens

uniprot P05130 283
type: UnificationXref
id: P05130
db: uniprot

uniprot Q7SE08 139
type: UnificationXref
id: Q7SE08
db: uniprot

uniprot H2Q3W7 395
type: UnificationXref
id: H2Q3W7
db: uniprot

uniprot G5EFI8 85
type: UnificationXref
id: G5EFI8
db: uniprot

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: uniprot Q28FH0 457
xref: PTHR10218:SF316
organism: Xenopus tropicalis

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6VVA6 75
xref: PTHR10336:SF12
organism: Ornithorhynchus anatinus

uniprot Q01717 29
type: UnificationXref
id: Q01717
db: uniprot

uniprot Q0V7N0 216
type: UnificationXref
id: Q0V7N0
db: uniprot

uniprot Q9QW07 158
type: UnificationXref
id: Q9QW07
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 493
organism: Homo sapiens

uniprot P30671 419
type: UnificationXref
id: P30671
db: uniprot

Pro-thyrotropin-releasing hormone
type: ProteinReference
xref: uniprot P20396 513
xref: PTHR17530:SF2
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: uniprot F7DVL1 271
xref: PTHR24356:SF214
organism: Xenopus tropicalis

Glycoprotein hormones alpha chain
type: ProteinReference
xref: PTHR11509:SF0
xref: uniprot P11962 511
organism: Rattus norvegicus

Protein kinase C
type: ProteinReference
xref: uniprot H2QAS6 276
xref: PTHR24356:SF158
organism: Pan troglodytes

uniprot F1NLV4 353
type: UnificationXref
id: F1NLV4
db: uniprot

Complex (TRH Receptor/TRH)
type: Complex
component stoichiometry: TRH s20 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRH Receptor s42 sa10 STOICHIOMETRY ID COMPLEX
component: TRH Receptor
component: TRH
feature: COMPLEX BINDING FEATURE s27 a41 571
feature: COMPLEX BINDING FEATURE s27 a41 569
cellular location: cytosol

uniprot Q00975 554
type: UnificationXref
id: Q00975
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 359
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re14 617
type: Stoichiometry
physical entity: Thyrotropin
stoichiometric coefficient: 1.0

uniprot P23625 414
type: UnificationXref
id: P23625
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot E1BQN6 255
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY re14 616
type: Stoichiometry
physical entity: Thyrotropin
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7AQR3 371
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 368
organism: Monodelphis domestica

uniprot Q02294 555
type: UnificationXref
id: Q02294
db: uniprot

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 332
organism: Ixodes scapularis

uniprot Q62074 313
type: UnificationXref
id: Q62074
db: uniprot

uniprot D3ZLD6 337
type: UnificationXref
id: D3ZLD6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 366
organism: Macaca mulatta

uniprot Q39033 125
type: UnificationXref
id: Q39033
db: uniprot

PANTHER Pathway P04394 1
type: UnificationXref
id: P04394
db: PANTHER Pathway

uniprot F2Z3T8 356
type: UnificationXref
id: F2Z3T8
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot H2RB55 89
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 490
organism: Mus musculus

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot H2Q8F2 275
organism: Pan troglodytes

uniprot Q15147 119
type: UnificationXref
id: Q15147
db: uniprot

DAG
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot O95837 407
organism: Homo sapiens

uniprot F7HC75 274
type: UnificationXref
id: F7HC75
db: uniprot

Voltage-dependent L-type calcium channel subunit beta-2
type: ProteinReference
xref: uniprot Q8VGC3 565
xref: PTHR11824:SF9
organism: Rattus norvegicus

Voltage-dependent L-type calcium channel subunit beta-3 isoform 1
type: ProteinReference
xref: uniprot F6VB97 538
organism: Macaca mulatta

ncbitaxon 39947 134
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot A0A1D5R985 245
type: UnificationXref
id: A0A1D5R985
db: uniprot

uniprot P62874 438
type: UnificationXref
id: P62874
db: uniprot

uniprot E2R0P6 13
type: UnificationXref
id: E2R0P6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 372
organism: Macaca mulatta

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05771 284
xref: PTHR24356:SF158
organism: Homo sapiens

Glycoprotein hormones alpha chain
type: ProteinReference
xref: uniprot Q6QX43 515
organism: Danio rerio

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 415
organism: Drosophila melanogaster

uniprot F5HMB9 69
type: UnificationXref
id: F5HMB9
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 134

ncbitaxon 7668 196
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot Q19266 311
type: UnificationXref
id: Q19266
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q7SBR2 137
organism: Neurospora crassa

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF80
xref: uniprot F1R8S3 68
organism: Danio rerio

uniprot Q7T2C5 318
type: UnificationXref
id: Q7T2C5
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A0A1D5R985 245
xref: PTHR24356:SF193
organism: Macaca mulatta

uniprot P54285 550
type: UnificationXref
id: P54285
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 376
organism: Monodelphis domestica

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 461
organism: Emericella nidulans

uniprot P16520 409
type: UnificationXref
id: P16520
db: uniprot

uniprot H2Q1D9 394
type: UnificationXref
id: H2Q1D9
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6VM87 178
xref: PTHR19305:SF5
organism: Monodelphis domestica

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot Q99P84 153
organism: Rattus norvegicus

Protein kinase C delta type
type: ProteinReference
xref: uniprot P28867 295
xref: PTHR24356:SF365
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: uniprot E2RNP2 258
xref: PTHR24356:SF181
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3B5 464
xref: PTHR10218:SF316
organism: Gallus gallus

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Thyrotropin-RIGHT__Thyrotropin-_re14
control type: ACTIVATION
controller: Complex (SNARE COMPLEX/Ca2+)

uniprot F6W548 365
type: UnificationXref
id: F6W548
db: uniprot

uniprot O89040 96
type: UnificationXref
id: O89040
db: uniprot

uniprot O00305 545
type: UnificationXref
id: O00305
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa2 576
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 70

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7A632 268
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 352
organism: Bos taurus

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Uncharacterized protein
type: ProteinReference
xref: uniprot F7B1S0 540
organism: Macaca mulatta

SNARE COMPLEX
type: Protein
entity reference: SNARE COMPLEX
feature: ACTIVE 163
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa12 592
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q9STZ3 159
type: UnificationXref
id: Q9STZ3
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot Q9P212 157
organism: Homo sapiens

uniprot F6Z8A1 77
type: UnificationXref
id: F6Z8A1
db: uniprot

uniprot A0A1D5P3F4 5
type: UnificationXref
id: A0A1D5P3F4
db: uniprot

uniprot Q944C1 150
type: UnificationXref
id: Q944C1
db: uniprot

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O09044 194
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 373
organism: Macaca mulatta

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 486
organism: Danio rerio

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF80
xref: uniprot K7C8Z4 95
organism: Pan troglodytes

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF80
xref: uniprot F6SRP9 72
organism: Macaca mulatta

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A8X8S6 170
xref: PTHR19305:SF14
organism: Caenorhabditis briggsae

uniprot Q62442 227
type: UnificationXref
id: Q62442
db: uniprot

uniprot P54287 551
type: UnificationXref
id: P54287
db: uniprot

SNARE COMPLEX
type: Protein
entity reference: SNARE COMPLEX
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot E1BQN6 255
type: UnificationXref
id: E1BQN6
db: uniprot

Thyrotropin-releasing hormone receptor
type: ProteinReference
xref: uniprot O46639 23
xref: PTHR46061:SF2
organism: Bos taurus

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q63666 228
xref: PTHR45701:SF1
organism: Rattus norvegicus

uniprot A0A1D5QYR9 166
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

uniprot P32383 108
type: UnificationXref
id: P32383
db: uniprot

uniprot F6Y3N2 368
type: UnificationXref
id: F6Y3N2
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q7SZZ5 232
organism: Danio rerio

uniprot P54313 433
type: UnificationXref
id: P54313
db: uniprot

uniprot P91645 552
type: UnificationXref
id: P91645
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 459
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot P16054 290
xref: PTHR24356:SF159
organism: Mus musculus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot F7EG64 272
organism: Xenopus tropicalis

uniprot F6UBJ8 176
type: UnificationXref
id: F6UBJ8
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 345
organism: Canis lupus familiaris

Complex (GDP/G-Protein/ TRH Receptor/TRH)
type: Complex
component stoichiometry: GDP s12 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRH s18 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s45 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRH Receptor s17 sa8 STOICHIOMETRY ID COMPLEX
component: TRH
component: TRH Receptor
component: G-Protein
component: GDP
feature: COMPLEX BINDING FEATURE s26 a40 577
feature: COMPLEX BINDING FEATURE s26 a40 581
feature: COMPLEX BINDING FEATURE s26 a40 579
feature: COMPLEX BINDING FEATURE s26 a40 583
cellular location: cytosol

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot F1P3G1 263
organism: Gallus gallus

uniprot O57340 503
type: UnificationXref
id: O57340
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 406
organism: Homo sapiens

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot D4A978 53
xref: PTHR10336:SF33
organism: Rattus norvegicus

TRANSPORT_LEFT__Thyrotropin-RIGHT__Thyrotropin-_re14
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 617
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 616
left: Thyrotropin
interaction type: TRANSPORT
right: Thyrotropin

uniprot F6V461 363
type: UnificationXref
id: F6V461
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re2
controller: DAG

uniprot G3V8K2 391
type: UnificationXref
id: G3V8K2
db: uniprot

uniprot Q64704 229
type: UnificationXref
id: Q64704
db: uniprot

uniprot Q5ZJ03 469
type: UnificationXref
id: Q5ZJ03
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
type: ProteinReference
xref: PTHR10336:SF31
xref: uniprot Q8K3R3 145
organism: Mus musculus

TRH
type: Protein
entity reference: TRH
comment: SPECIES_TYPE=PROTEIN

GO GO:0070382 3
type: UnificationXref
id: GO:0070382
db: GO

uniprot J9P702 400
type: UnificationXref
id: J9P702
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 337
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AUF1 17
xref: PTHR46061:SF2
organism: Monodelphis domestica

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa13 594
cellular location: exocytic vesicle
comment: SPECIES_TYPE=ION

Voltage-dependent L-type calcium channel subunit beta-4
type: ProteinReference
xref: uniprot D4A055 529
organism: Rattus norvegicus

uniprot Q15836 218
type: UnificationXref
id: Q15836
db: uniprot

uniprot Q8K2J0 143
type: UnificationXref
id: Q8K2J0
db: uniprot

uniprot P63217 449
type: UnificationXref
id: P63217
db: uniprot

uniprot H2QZN8 398
type: UnificationXref
id: H2QZN8
db: uniprot

Pro-thyrotropin-releasing hormone
type: ProteinReference
xref: uniprot P01150 504
xref: PTHR17530:SF2
organism: Rattus norvegicus

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

uniprot F6PVT7 359
type: UnificationXref
id: F6PVT7
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 111

uniprot P33328 202
type: UnificationXref
id: P33328
db: uniprot

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

uniprot Q02641 556
type: UnificationXref
id: Q02641
db: uniprot

uniprot A0A2I3RKF6 41
type: UnificationXref
id: A0A2I3RKF6
db: uniprot

uniprot H9FVW1 91
type: UnificationXref
id: H9FVW1
db: uniprot

Voltage-dependent calcium channel type A subunit alpha-1
type: ProteinReference
xref: PTHR45628:SF7
xref: uniprot P91645 552
organism: Drosophila melanogaster

uniprot O46639 23
type: UnificationXref
id: O46639
db: uniprot

uniprot F5HH30 357
type: UnificationXref
id: F5HH30
db: uniprot

ncbitaxon 7739 336
type: UnificationXref
id: 7739
db: ncbitaxon

GTP s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot F6PGC8 358
type: UnificationXref
id: F6PGC8
db: uniprot

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 608
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 609
left: PKC
interaction type: STATE_TRANSITION
right: PKC

uniprot F6ZKL2 79
type: UnificationXref
id: F6ZKL2
db: uniprot

uniprot Q64617 314
type: UnificationXref
id: Q64617
db: uniprot

uniprot Q803H5 486
type: UnificationXref
id: Q803H5
db: uniprot

Voltage-dependent L-type calcium channel subunit beta-3
type: ProteinReference
xref: uniprot A0A3Q1LQ06 525
organism: Bos taurus

uniprot P17343 410
type: UnificationXref
id: P17343
db: uniprot

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

uniprot Q6PBR4 478
type: UnificationXref
id: Q6PBR4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 452
organism: Xenopus tropicalis

uniprot P05129 282
type: UnificationXref
id: P05129
db: uniprot

uniprot F7E427 377
type: UnificationXref
id: F7E427
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 481
organism: Danio rerio

ncbitaxon 9615 14
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot E2RJB3 346
type: UnificationXref
id: E2RJB3
db: uniprot

uniprot H2RC03 544
type: UnificationXref
id: H2RC03
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 455
organism: Caenorhabditis elegans

ncbitaxon 6239 32
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot H2Q3R5 187
type: UnificationXref
id: H2Q3R5
db: uniprot

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 329
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 28

uniprot A0A3Q1MSP9 250
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

uniprot E2RCN6 531
type: UnificationXref
id: E2RCN6
db: uniprot

uniprot A0A2R8QJ48 248
type: UnificationXref
id: A0A2R8QJ48
db: uniprot

uniprot P09217 287
type: UnificationXref
id: P09217
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q28HP6 220
xref: PTHR19305:SF5
organism: Xenopus tropicalis

uniprot F7G1K7 384
type: UnificationXref
id: F7G1K7
db: uniprot

uniprot F1N1E0 533
type: UnificationXref
id: F1N1E0
db: uniprot

uniprot M9PE71 191
type: UnificationXref
id: M9PE71
db: uniprot

Voltage-dependent N-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot G3X7Z2 542
xref: PTHR10037:SF289
organism: Bos taurus

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 196

uniprot A5PEW5 169
type: UnificationXref
id: A5PEW5
db: uniprot

uniprot H2Q8F2 275
type: UnificationXref
id: H2Q8F2
db: uniprot

Thyrotropin
type: ProteinReference
xref: P04588
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Thyrotropin Synonym: TSH,Thyroid Stimulating Hormone Accession: P04588
comment: ENTITY_REFERENCE_ID_DESC=Thyrotropin-releasing hormone receptor signaling pathway.PROTEIN.GENERIC.Thyrotropin
member entity reference: Thyrotropin subunit beta
member entity reference: Thyroid stimulating hormone, beta subunit
member entity reference: Glycoprotein hormones alpha chain
member entity reference: Thyroid stimulating hormone beta subunit
member entity reference: TSHB isoform 1

PTHR45628:SF7
type: RelationshipXref
id: PTHR45628:SF7
db: PANTHER Family
relationship type: By Homology

PTHR45628:SF6
type: RelationshipXref
id: PTHR45628:SF6
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 340
organism: Gallus gallus

PTHR45628:SF5
type: RelationshipXref
id: PTHR45628:SF5
db: PANTHER Family
relationship type: By Homology

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2Q995 188
type: UnificationXref
id: H2Q995
db: uniprot

PTHR45628:SF3
type: RelationshipXref
id: PTHR45628:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q5BJ11 462
type: UnificationXref
id: Q5BJ11
db: uniprot

uniprot F7ES96 381
type: UnificationXref
id: F7ES96
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
type: ProteinReference
xref: uniprot P32383 108
organism: Saccharomyces cerevisiae

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

uniprot Q13277 217
type: UnificationXref
id: Q13277
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 496
organism: Gallus gallus

uniprot A0A3Q1LQ06 525
type: UnificationXref
id: A0A3Q1LQ06
db: uniprot

Atypical protein kinase C
type: ProteinReference
xref: uniprot A1Z9X0 251
xref: PTHR24356:SF303
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 381
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 353
organism: Gallus gallus

uniprot Q08BT6 310
type: UnificationXref
id: Q08BT6
db: uniprot

uniprot Q62711 131
type: UnificationXref
id: Q62711
db: uniprot

uniprot F7BB02 373
type: UnificationXref
id: F7BB02
db: uniprot

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: uniprot B8JLJ7 334
xref: PTHR10218:SF316
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 391
organism: Rattus norvegicus

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 201
organism: Saccharomyces cerevisiae

uniprot P01150 504
type: UnificationXref
id: P01150
db: uniprot

TRH Receptor
type: Protein
entity reference: TRH Receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa8 582
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re6 603
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 602
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6REU0 535
xref: PTHR11824:SF9
organism: Monodelphis domestica

uniprot Q9MZL7 567
type: UnificationXref
id: Q9MZL7
db: uniprot

uniprot Q8K4D7 146
type: UnificationXref
id: Q8K4D7
db: uniprot

uniprot P63213 445
type: UnificationXref
id: P63213
db: uniprot

uniprot F6SSS3 360
type: UnificationXref
id: F6SSS3
db: uniprot

ncbitaxon 284812 111
type: UnificationXref
id: 284812
db: ncbitaxon

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1MKT3 58
xref: PTHR10336:SF31
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: uniprot Q7T2C5 318
xref: PTHR24356:SF158
organism: Danio rerio

uniprot P29829 417
type: UnificationXref
id: P29829
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 330
organism: Sclerotinia sclerotiorum

TRH Receptor
type: Protein
entity reference: TRH Receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa10 570
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6SD46 71
type: UnificationXref
id: F6SD46
db: uniprot

uniprot Q3USB7 126
type: UnificationXref
id: Q3USB7
db: uniprot

Motilin receptor
type: ProteinReference
xref: uniprot Q9R297 34
organism: Rattus norvegicus

SNAP29 isoform 1
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot H2QLA1 189
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot A0A2J8QDF6 46
organism: Pan troglodytes

uniprot Q08289 559
type: UnificationXref
id: Q08289
db: uniprot

uniprot F6VB97 538
type: UnificationXref
id: F6VB97
db: uniprot

uniprot F6TKH3 537
type: UnificationXref
id: F6TKH3
db: uniprot

Inactive phospholipase C-like protein 1
type: ProteinReference
xref: uniprot Q3USB7 126
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot P16885 105
organism: Homo sapiens

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q9WTQ0 321
xref: PTHR24356:SF181
organism: Rattus norvegicus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 117

uniprot F7A943 183
type: UnificationXref
id: F7A943
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 356
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F6Z8A1 77
organism: Xenopus tropicalis

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: PTHR10336:SF80
xref: uniprot P10688 100
organism: Rattus norvegicus

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa3 586
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P01216 506
type: UnificationXref
id: P01216
db: uniprot

uniprot Q9Z1B3 162
type: UnificationXref
id: Q9Z1B3
db: uniprot

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 557

uniprot Q62077 129
type: UnificationXref
id: Q62077
db: uniprot

uniprot F7BIC2 269
type: UnificationXref
id: F7BIC2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 403
organism: Monodelphis domestica

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot J9JHK9 93
xref: PTHR10336:SF11
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 487
organism: Mus musculus

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot P09217 287
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot P09216 286
xref: PTHR24356:SF159
organism: Rattus norvegicus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P09215 285
organism: Rattus norvegicus

uniprot H2QNS5 397
type: UnificationXref
id: H2QNS5
db: uniprot

uniprot P50151 428
type: UnificationXref
id: P50151
db: uniprot

PARTICIPANT STOICHIOMETRY re1 611
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P10686 98
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re1 612
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10687 99
xref: PTHR10336:SF12
organism: Rattus norvegicus

uniprot Q90Z40 488
type: UnificationXref
id: Q90Z40
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 488
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re1 610
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A1D5QLW6 38
xref: PTHR10336:SF25
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: PTHR10336:SF80
xref: uniprot Q8R3B1 148
organism: Mus musculus

Protein kinase C-like 1
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot P34722 296
organism: Caenorhabditis elegans

Pro-thyrotropin-releasing hormone
type: ProteinReference
xref: uniprot H2QNC9 502
xref: PTHR17530:SF2
organism: Pan troglodytes

EGL-30
type: ProteinReference
xref: PTHR10218:SF329
xref: uniprot G5EGU1 392
organism: Caenorhabditis elegans

uniprot Q63666 228
type: UnificationXref
id: Q63666
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F7E2P1 82
organism: Monodelphis domestica

uniprot Q9N0Y0 238
type: UnificationXref
id: Q9N0Y0
db: uniprot

uniprot P10895 102
type: UnificationXref
id: P10895
db: uniprot

uniprot O09044 194
type: UnificationXref
id: O09044
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: uniprot Q05513 308
xref: PTHR24356:SF170
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 370
organism: Macaca mulatta

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9258 76
type: UnificationXref
id: 9258
db: ncbitaxon

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot F7H3B3 273
organism: Macaca mulatta

G Protein s8 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot F7CTP1 375
type: UnificationXref
id: F7CTP1
db: uniprot

uniprot Q9W1I8 242
type: UnificationXref
id: Q9W1I8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BZF6 530
xref: PTHR11824:SF9
organism: Gallus gallus

uniprot F6ZIZ9 370
type: UnificationXref
id: F6ZIZ9
db: uniprot

AGAP012252-PA (Fragment)
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot Q7Q042 315
organism: Anopheles gambiae

ncbitaxon 44689 117
type: UnificationXref
id: 44689
db: ncbitaxon

Protein kinase C delta type
type: ProteinReference
xref: uniprot H9EU39 278
xref: PTHR24356:SF365
organism: Macaca mulatta

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 186
organism: Caenorhabditis elegans

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: uniprot Q02641 556
xref: PTHR11824:SF17
organism: Homo sapiens

TRH
type: Protein
entity reference: TRH
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa9 584
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1NG47 262
type: UnificationXref
id: F1NG47
db: uniprot

Thyrotropin
type: Protein
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1MMD9 47
type: UnificationXref
id: A0A3Q1MMD9
db: uniprot

PARTICIPANT STOICHIOMETRY re9 601
type: Stoichiometry
physical entity: TRH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 600
type: Stoichiometry
physical entity: ProTRH (Pro Thyrotropin-releasing Hormone)
stoichiometric coefficient: 1.0

uniprot P31109 201
type: UnificationXref
id: P31109
db: uniprot

uniprot F6VT32 266
type: UnificationXref
id: F6VT32
db: uniprot

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P17252 291
xref: PTHR24356:SF193
organism: Homo sapiens

Thyrotropin-releasing hormone receptor
type: ProteinReference
xref: uniprot P34981 27
xref: PTHR46061:SF2
organism: Homo sapiens

uniprot Q9JID2 492
type: UnificationXref
id: Q9JID2
db: uniprot

By Homology
type: RelationshipTypeVocabulary

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot P23763 200
xref: PTHR45701:SF1
organism: Homo sapiens

uniprot Q7PW25 135
type: UnificationXref
id: Q7PW25
db: uniprot

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 399
organism: Pan troglodytes

TRH Receptor s17 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRH Receptor
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q9VXH3 160
organism: Drosophila melanogaster

G Protein s45 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Glycoprotein hormones alpha chain
type: ProteinReference
xref: PTHR11509:SF0
xref: uniprot Q9XSW8 517
organism: Canis lupus familiaris

Protein kinase C
type: ProteinReference
xref: uniprot A0A2R8QJ48 248
xref: PTHR24356:SF192
organism: Danio rerio

Calcium voltage-gated channel auxiliary subunit beta 3
type: ProteinReference
xref: uniprot A0A2I3TDB2 522
organism: Pan troglodytes

uniprot F1PJE5 355
type: UnificationXref
id: F1PJE5
db: uniprot

ncbitaxon 6945 333
type: UnificationXref
id: 6945
db: ncbitaxon

STATE_TRANSITION
type: InteractionVocabulary

Pro-thyrotropin-releasing hormone
type: ProteinReference
xref: PTHR17530:SF2
xref: uniprot Q62361 514
organism: Mus musculus

TRANSPORT
type: InteractionVocabulary

ncbitaxon 559292 109
type: UnificationXref
id: 559292
db: ncbitaxon

HETERODIMER_ASSOCIATION_LEFT__SNARE_COMPLEX-_Ca2_PLUS_-RIGHT__Complex__SNARE_COMPLEX_Ca2_PLUS__-_re15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 613
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 615
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 614
left: Ca2+
left: SNARE COMPLEX
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SNARE COMPLEX/Ca2+)

uniprot Q7PXP3 482
type: UnificationXref
id: Q7PXP3
db: uniprot

uniprot Q3KRE3 459
type: UnificationXref
id: Q3KRE3
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot Q8CIH5 141
organism: Mus musculus

Thyrotropin-releasing hormone receptor 2
type: ProteinReference
xref: uniprot F7ERM9 22
organism: Xenopus tropicalis

uniprot Q9ERB0 236
type: UnificationXref
id: Q9ERB0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A1D5Q4D0 37
xref: PTHR10336:SF11
organism: Macaca mulatta

uniprot P52287 431
type: UnificationXref
id: P52287
db: uniprot

uniprot A0A1D5QXV8 39
type: UnificationXref
id: A0A1D5QXV8
db: uniprot

Voltage-dependent L-type calcium channel subunit beta-4
type: ProteinReference
xref: uniprot Q8R0S4 563
organism: Mus musculus

uniprot A0A2I3SR38 247
type: UnificationXref
id: A0A2I3SR38
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF51
xref: uniprot A0A096MJW8 35
organism: Rattus norvegicus

uniprot F1A421 350
type: UnificationXref
id: F1A421
db: uniprot

uniprot P36408 421
type: UnificationXref
id: P36408
db: uniprot

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

uniprot P21279 413
type: UnificationXref
id: P21279
db: uniprot

uniprot P05126 280
type: UnificationXref
id: P05126
db: uniprot

uniprot P63212 444
type: UnificationXref
id: P63212
db: uniprot

uniprot F1P3G1 263
type: UnificationXref
id: F1P3G1
db: uniprot

uniprot Q7QHE3 136
type: UnificationXref
id: Q7QHE3
db: uniprot

Voltage-dependent R-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF5
xref: uniprot A0A3Q1LZY8 526
organism: Bos taurus

uniprot F1R8S3 68
type: UnificationXref
id: F1R8S3
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q04759 307
xref: PTHR24356:SF181
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot A0A3Q1MSP9 250
organism: Bos taurus

uniprot Q9WUF4 243
type: UnificationXref
id: Q9WUF4
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
type: ProteinReference
xref: uniprot P25455 107
organism: Drosophila melanogaster

uniprot P50153 429
type: UnificationXref
id: P50153
db: uniprot

Syntaxin 3A
type: ProteinReference
xref: uniprot Q6PHV0 231
xref: PTHR19957:SF34
organism: Danio rerio

uniprot P09215 285
type: UnificationXref
id: P09215
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 380
organism: Ornithorhynchus anatinus

uniprot F1M324 57
type: UnificationXref
id: F1M324
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 364
organism: Ornithorhynchus anatinus

Syntaxin 3
type: ProteinReference
xref: uniprot F7EPG4 184
xref: PTHR19957:SF34
organism: Ornithorhynchus anatinus

uniprot P21278 412
type: UnificationXref
id: P21278
db: uniprot

uniprot Q9UBI6 493
type: UnificationXref
id: Q9UBI6
db: uniprot

uniprot F6YZA3 369
type: UnificationXref
id: F6YZA3
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 421
organism: Dictyostelium discoideum

uniprot E1BA29 338
type: UnificationXref
id: E1BA29
db: uniprot

uniprot Q8R3Z5 564
type: UnificationXref
id: Q8R3Z5
db: uniprot

uniprot P23763 200
type: UnificationXref
id: P23763
db: uniprot

uniprot P26308 415
type: UnificationXref
id: P26308
db: uniprot

uniprot P29992 418
type: UnificationXref
id: P29992
db: uniprot