PARTICIPANT STOICHIOMETRY r20 487
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 488
type: Stoichiometry
physical entity: MKK3
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IKKalpha-_ATP-RIGHT__IKKalpha-_ADP-_r85
controller: TAK1

PARTICIPANT STOICHIOMETRY r20 486
type: Stoichiometry
physical entity: MKK3
stoichiometric coefficient: 1.0

Complex (PG, LP/TLR1,2,6)
type: Complex
component stoichiometry: PG, LP s12 sa9 STOICHIOMETRY ID COMPLEX
component: TLR1,2,6
component: PG, LP
feature: COMPLEX BINDING FEATURE s114 a170 324
feature: COMPLEX BINDING FEATURE s114 a170 326
cellular location: cytosol

PARTICIPANT STOICHIOMETRY r20 489
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TLR4
type: ProteinReference
xref: P01339
standard name: Toll-like receptor 4
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.RECEPTOR.TLR4
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Uncharacterized protein
member entity reference: TLR4 isoform 1
member entity reference: Toll-like receptor 4

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: uniprot H9Z267 266
organism: Macaca mulatta

TBK1
type: Protein
entity reference: TBK1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1LK92 172
type: UnificationXref
id: A0A3Q1LK92
db: uniprot

uniprot Q9DGD9 253
type: UnificationXref
id: Q9DGD9
db: uniprot

TLR4 s22 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TLR4
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r96 426
type: Stoichiometry
physical entity: Complex (TAK1/TRAF6/ TAB2/TAB1/ MEKK1/ECSIT)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r96 425
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 3

PARTICIPANT STOICHIOMETRY r96 424
type: Stoichiometry
physical entity: ECSIT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r96 423
type: Stoichiometry
physical entity: MEKK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r96 422
type: Stoichiometry
physical entity: Complex (TAK1/TAB2/ TAB1)
stoichiometric coefficient: 1.0

MyD88
type: Protein
entity reference: MyD88
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q6WCD5 25
type: UnificationXref
id: Q6WCD5
db: uniprot

IKKepsilon
type: Protein
entity reference: IKKepsilon
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MD-2
type: Protein
entity reference: MD-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa11 335
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

JNK
type: Protein
entity reference: JNK
feature: JNK s39 a56 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ubiquitin-conjugating enzyme E2 variant 1
type: ProteinReference
xref: uniprot F7EKS7 259
organism: Xenopus tropicalis

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P79996 251
organism: Gallus gallus

p38 s46 a68 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TPL2 s49 a75 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TRIF
type: ProteinReference
xref: P01344
standard name: TIR domain-containing adaptor inducing interferon (IFN)-beta
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.TRIF
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: TIR domain-containing adaptor inducing interferon (IFN)-beta Synonym: TICAM-1,TIR-containing adaptor molecule ,TRIF Accession: P01344
member entity reference: TIR domain-containing adapter molecule 2
member entity reference: Toll like receptor adaptor molecule 1
member entity reference: Uncharacterized protein
member entity reference: TIR domain-containing adapter molecule 1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK4-_ATP-RIGHT__ADP-_MKK4-_r81
controller: Complex (TAK1/TRAF6/ TAB2/TAB1/ MEKK1/ECSIT)

uniprot W4YET5 99
type: UnificationXref
id: W4YET5
db: uniprot

JNK s39 a56 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__ERK2-_ATP-RIGHT__ADP-_ERK2-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 448
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 449
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 447
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 446
left: ERK2
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: ERK2

TRAF6
type: Protein
entity reference: TRAF6
feature: TRAF6 s15 a113 rs2
feature: K63 TRAF6 s15 a113 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re43 414
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

uniprot A4GTP4 34
type: UnificationXref
id: A4GTP4
db: uniprot

TAB1
type: Protein
entity reference: TAB1
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa23 357
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mus musculus
type: BioSource
xref: ncbitaxon 10090 21

PARTICIPANT STOICHIOMETRY re43 413
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

TANK
type: ProteinReference
xref: P01353
standard name: TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.TANK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR Synonym: ITRAF,TANK,TRAF-INTERACTING PROTEIN Accession: P01353
member entity reference: TRAF family member-associated NF-kappa-B activator
member entity reference: TRAF family member associated NFKB activator
member entity reference: TRAF family member-associated NF-kappa-B activator isoform a
member entity reference: TRAF family member-associated NFKB activator

uniprot F6ZKB3 244
type: UnificationXref
id: F6ZKB3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AP1-_ATP-RIGHT__AP1-_ADP-_r19
controller: p38

uniprot O02812 121
type: UnificationXref
id: O02812
db: uniprot

uniprot F7CCD5 216
type: UnificationXref
id: F7CCD5
db: uniprot

MKK3
type: Protein
entity reference: MKK3
feature: MKK3 s47 a69 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2R0G7 247
type: UnificationXref
id: H2R0G7
db: uniprot

PANTHER Pathway P00054 1
type: UnificationXref
id: P00054
db: PANTHER Pathway

uniprot Q7Q0C5 83
type: UnificationXref
id: Q7Q0C5
db: uniprot

uniprot H2Q867 10
type: UnificationXref
id: H2Q867
db: uniprot

MKK3 s47 a69 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A2RUW1 276
type: UnificationXref
id: A2RUW1
db: uniprot

NF-kappaB
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 151
organism: Homo sapiens

uniprot H2QT35 12
type: UnificationXref
id: H2QT35
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot O77627 137
organism: Bos taurus

TLR
type: Protein
entity reference: TLR

MKK3
type: Protein
entity reference: MKK3
feature: MKK3 s45 a67 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IkappaB s6 sa3 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6UZJ7 77
type: UnificationXref
id: F6UZJ7
db: uniprot

TBK1 s24 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBK1
stoichiometric coefficient: 1.0

uniprot F1NKD9 258
type: UnificationXref
id: F1NKD9
db: uniprot

TNF alpha induced protein 3
type: ProteinReference
xref: uniprot H2QTT5 108
organism: Pan troglodytes

uniprot Q13404 263
type: UnificationXref
id: Q13404
db: uniprot

JNK s38 a55 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2I3T3V8 66
organism: Pan troglodytes

Elk1 s120 a175 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Interferon regulatory factor 3
type: ProteinReference
xref: uniprot Q14653 236
organism: Homo sapiens

uniprot F7DY40 107
type: UnificationXref
id: F7DY40
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1B847 142
xref: PTHR24361:SF414
organism: Bos taurus

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot A4GTP4 34
organism: Rattus norvegicus

MKK2 s53 a79 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

IkappaB
type: Protein
entity reference: IkappaB
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa3 315
feature: IkappaB s6 sa3 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q01986 206
organism: Rattus norvegicus

PTHR13832:SF533
type: RelationshipXref
id: PTHR13832:SF533
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re42 418
type: Stoichiometry
physical entity: IKKepsilon
stoichiometric coefficient: 1.0

Complex (Ubc13/Uev1A)
type: Complex
component stoichiometry: Uev1A s4 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ubc13 s2 sa1 STOICHIOMETRY ID COMPLEX
component: Uev1A
component: Ubc13
feature: COMPLEX BINDING FEATURE s18 a27 312
feature: COMPLEX BINDING FEATURE s18 a27 310
cellular location: cytosol

Toll-like receptor 7
type: ProteinReference
xref: uniprot Q7KIN0 82
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re42 417
type: Stoichiometry
physical entity: IKKepsilon
stoichiometric coefficient: 1.0

uniprot Q9Z1E3 20
type: UnificationXref
id: Q9Z1E3
db: uniprot

Interleukin-1 receptor-associated kinase 4
type: ProteinReference
xref: uniprot Q8R4K2 42
organism: Mus musculus

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
type: ProteinReference
xref: uniprot Q9BQ95 112
organism: Homo sapiens

IRAK1 s65 sa29 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VNC5 103
organism: Macaca mulatta

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot Q95KV0 161
xref: PTHR22969:SF7
organism: Bos taurus

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot Q95KV1 63
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r19 373
type: Stoichiometry
physical entity: AP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 374
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 375
type: Stoichiometry
physical entity: AP1
stoichiometric coefficient: 1.0

Toll receptor signaling pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__IKKgamma-_IKKalpha-RIGHT__IKKbeta-_r72
pathway component: STATE_TRANSITION_LEFT__ERK1-_ATP-RIGHT__ERK1-_ADP-_r25
pathway component: STATE_TRANSITION_LEFT__ATP-_TAK1-RIGHT__TAK1-_ADP-_r50
pathway component: STATE_TRANSITION_LEFT__MKK2-_ATP-RIGHT__MKK2-_ADP-_r24
pathway component: STATE_TRANSITION_LEFT__TRIF-RIGHT__TRIF-_r101
pathway component: STATE_TRANSITION_LEFT__ERK2-_ATP-RIGHT__ADP-_ERK2-_r26
pathway component: STATE_TRANSITION_LEFT__ATP-_TPL2-RIGHT__TPL2-_ADP-_r22
pathway component: STATE_TRANSITION_LEFT__MKK3-_ATP-RIGHT__MKK3-_ADP-_r20
pathway component: STATE_TRANSITION_LEFT__TRAF6-_ATP-RIGHT__TRAF6-_ADP-_r37
pathway component: UNKNOWN_TRANSITION_LEFT__IKKepsilon-RIGHT__IKKepsilon-_re42
pathway component: STATE_TRANSITION_LEFT__AP1-_ATP-RIGHT__AP1-_ADP-_r19
pathway component: STATE_TRANSITION_LEFT__MKK1-_ATP-RIGHT__MKK1-_ADP-_r23
pathway component: HETERODIMER_ASSOCIATION_LEFT__IRAK4-_IRAK1-RIGHT__Complex__IRAK4_IRAK1_-_r103
pathway component: STATE_TRANSITION_LEFT__IKKbeta-_ATP-RIGHT__ADP-_IKKbeta-_r73
pathway component: TRANSCRIPTION_LEFT__Genes-RIGHT__RNA-_re41
pathway component: STATE_TRANSITION_LEFT__TAB2-_ATP-RIGHT__ADP-_TAB2-_r94
pathway component: STATE_TRANSITION_LEFT__Elk1-_ATP-RIGHT__Elk1-_ADP-_r75
pathway component: STATE_TRANSITION_LEFT__IRF3-_ATP-RIGHT__ADP-_IRF3-_r90
pathway component: DISSOCIATION_LEFT__Complex__IRAK4_IRAK1_-_ATP-RIGHT__IRAK4-_IRAK1-_ADP-_r104
pathway component: STATE_TRANSITION_LEFT__Tollip-_ATP-RIGHT__Tollip-_ADP-_r71
pathway component: STATE_TRANSITION_LEFT__Complex__IkappaB_NF_kappaB_-_ATP-RIGHT__IkappaB-_ADP-_NF_kappaB-_r14
pathway component: STATE_TRANSITION_LEFT__Ubiquitin-_TRAF6-RIGHT__TRAF6-_r9
pathway component: UNKNOWN_TRANSITION_LEFT__TRAF6-RIGHT__TRAF6-_re43
pathway component: STATE_TRANSITION_LEFT__p38-_ATP-RIGHT__p38-_ADP-_r21
pathway component: UNKNOWN_TRANSITION_LEFT__IRAK1-RIGHT__IRAK1-_re45
pathway component: STATE_TRANSITION_LEFT__JNK-_ATP-RIGHT__JNK-_ADP-_r17
pathway component: UNKNOWN_TRANSITION_LEFT__IRAK4-RIGHT__IRAK4-_re44
pathway component: STATE_TRANSITION_LEFT__MyD88-RIGHT__MyD88-_r99
pathway component: STATE_TRANSITION_LEFT__PAMP-_TLR-RIGHT__Complex__TLR_PAMP_-_r98
pathway component: STATE_TRANSITION_LEFT__MKK6-_ATP-RIGHT__MKK6-_ADP-_r13
pathway component: STATE_TRANSITION_LEFT__IKKalpha-_ATP-RIGHT__IKKalpha-_ADP-_r85
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__TAK1_TAB2__TAB1_-_MEKK1-_ECSIT-_TRAF6-RIGHT__Complex__TAK1_TRAF6__TAB2_TAB1__MEKK1_ECSIT_-_r96
pathway component: HETERODIMER_ASSOCIATION_LEFT__TIRAP-_MyD88-RIGHT__Complex__TIRAP_MyD88_-_r105
pathway component: STATE_TRANSITION_LEFT__MKK4-_ATP-RIGHT__ADP-_MKK4-_r81
pathway component: STATE_TRANSITION_LEFT__IRAK4-RIGHT__IRAK4-_r100
pathway component: HETERODIMER_ASSOCIATION_LEFT__TAB1-_TAK1-_TAB2-RIGHT__Complex__TAK1_TAB2__TAB1_-_r95
pathway component: HETERODIMER_ASSOCIATION_LEFT__TANK-_IKKepsilon-_TBK1-RIGHT__Complex__IKKepsilon_TBK1__TANK_-_r93
xref: PANTHER Pathway P00054 1
comment: MODEL_NOTES=Panther Pathway: P00054 Toll-like Receptor Pathway Signaling.

PARTICIPANT STOICHIOMETRY r19 376
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

AP1 s41 a60 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q7KIN0 82
type: UnificationXref
id: Q7KIN0
db: uniprot

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
type: ProteinReference
xref: PTHR13832:SF533
xref: uniprot Q15750 183
organism: Homo sapiens

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 11

Map2k3 protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot B1H230 187
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__TIRAP-_MyD88-RIGHT__Complex__TIRAP_MyD88_-_r105
controller: Complex (MD-2/CD14/ TLR4)

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P41969 36
organism: Mus musculus

uniprot Q9WUN2 171
type: UnificationXref
id: Q9WUN2
db: uniprot

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot F1NYZ2 195
xref: PTHR48013:SF8
organism: Gallus gallus

uniprot P08571 230
type: UnificationXref
id: P08571
db: uniprot

STATE_TRANSITION_LEFT__IKKalpha-_ATP-RIGHT__IKKalpha-_ADP-_r85
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 481
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 479
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 480
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 478
left: IKKalpha
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: IKKalpha

MEKK1
type: Protein
entity reference: MEKK1
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa24 359
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IKKbeta
type: Protein
entity reference: IKKbeta
feature: IKKbeta s117 a172 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q62406 49
type: UnificationXref
id: Q62406
db: uniprot

Mitogen-activated protein kinase kinase kinase 8
type: ProteinReference
xref: PTHR48016:SF31
xref: uniprot P41279 176
organism: Homo sapiens

IRAK4 s127 sa145 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TPL2
type: ProteinReference
xref: P01364
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: TPL2 Synonym: EST,ESTF,Ewing sarcoma transformant,MAP3K8,MAPKKK,Tumor progression locus 2,cot (cancer Osaka thyroid) oncogene,mitogen-activated protein kinase kinase kinase 8 Accession: P01364
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.TPL2
member entity reference: Mitogen-activated protein kinase kinase kinase 8
member entity reference: MAP3K8 isoform 1

uniprot A0A1D5QPH3 64
type: UnificationXref
id: A0A1D5QPH3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IKKalpha-_ATP-RIGHT__IKKalpha-_ADP-_r85
controller: Complex (TAK1/TRAF6/ TAB2/TAB1/ MEKK1/ECSIT)

Interleukin-1 receptor-associated kinase 4
type: ProteinReference
xref: uniprot D4A7K4 38
organism: Rattus norvegicus

p38
type: ProteinReference
xref: P01352
standard name: p38 mitogen activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: p38 Synonym: Synonym not specified Accession: P01352
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.p38
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 14B
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 14A

uniprot P61088 295
type: UnificationXref
id: P61088
db: uniprot

uniprot Q803J2 300
type: UnificationXref
id: Q803J2
db: uniprot

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot E2RKR0 156
organism: Canis lupus familiaris

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot E2RNA9 58
organism: Canis lupus familiaris

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q2TY19 239
xref: PTHR24055:SF222
organism: Gallus gallus

TRAF family member-associated NFKB activator
type: ProteinReference
xref: uniprot F1M101 131
organism: Rattus norvegicus

TAK1 s96 a65 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TRAF6
type: Protein
entity reference: TRAF6
feature: TRAF6 s94 a28 rs2
feature: K63 TRAF6 s94 a28 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__TAB2-_ATP-RIGHT__ADP-_TAB2-_r94
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 432
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 433
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 431
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 434
left: TAB2
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: TAB2

uniprot B3Y6A6 102
type: UnificationXref
id: B3Y6A6
db: uniprot

uniprot O88351 160
type: UnificationXref
id: O88351
db: uniprot

uniprot Q9Y4K3 225
type: UnificationXref
id: Q9Y4K3
db: uniprot

Tumor necrosis factor alpha-induced protein 3
type: ProteinReference
xref: uniprot P21580 109
organism: Homo sapiens

Complex (TAK1/TAB2/ TAB1)
type: Complex
component stoichiometry: TAB1 s31 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: TAB2 s28 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: TAK1 s27 sa17 STOICHIOMETRY ID COMPLEX
component: TAK1
component: TAB1
component: TAB2
feature: COMPLEX BINDING FEATURE s147 a211 322
feature: COMPLEX BINDING FEATURE s147 a211 318
feature: COMPLEX BINDING FEATURE s147 a211 320
cellular location: cytosol

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot A0A3Q1MNG1 186
xref: PTHR48013:SF21
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AP1-_ATP-RIGHT__AP1-_ADP-_r19
controller: JNK

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 125
xref: PTHR24055:SF110
organism: Pan troglodytes

TLR3 s9 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TLR3
stoichiometric coefficient: 2.0

Interleukin-1 receptor-associated kinase 4
type: ProteinReference
xref: uniprot Q9NWZ3 43
organism: Homo sapiens

uniprot E1B847 142
type: UnificationXref
id: E1B847
db: uniprot

IRAK4 s127 a3 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

IRF3
type: ProteinReference
xref: P01374
standard name: Interferon (INF) regulatory factor 3
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.IRF3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Interferon (INF) regulatory factor 3 Synonym: IRF3 Accession: P01374
member entity reference: Interferon regulatory factor 3

MEKK1
type: Protein
entity reference: MEKK1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot B3Y627 22
type: UnificationXref
id: B3Y627
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 154
organism: Mus musculus

Interleukin-1 receptor-associated kinase 3
type: ProteinReference
xref: uniprot Q9Y616 274
organism: Homo sapiens

MKK1
type: ProteinReference
xref: P01369
standard name: mitogen-activated protein kinase kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.MKK1
comment: ENTITY_REFERENCE_NOTES=Long Name: mitogen-activated protein kinase kinase 1 Synonym: MKK1 Accession: P01369
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: MAP2K1 protein

…
type: Stoichiometry
physical entity: TLR
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IRAK4-RIGHT__IRAK4-_r100
controller: Complex (TIRAP/MyD88)

ECSIT
type: ProteinReference
xref: P01349
standard name: evolutionarily conserved signaling intermediate in Toll pathways
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.ECSIT
comment: ENTITY_REFERENCE_NOTES=Long Name: evolutionarily conserved signaling intermediate in Toll pathways Synonym: ECSIT Accession: P01349
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
member entity reference: Uncharacterized protein

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot G3V926 60
organism: Rattus norvegicus

Uev1A s4 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Uev1A
stoichiometric coefficient: 1.0

Protein toll
type: ProteinReference
xref: PTHR24365:SF537
xref: uniprot P08953 80
organism: Drosophila melanogaster

uniprot Q8R4K2 42
type: UnificationXref
id: Q8R4K2
db: uniprot

uniprot P27361 151
type: UnificationXref
id: P27361
db: uniprot

K63 TRAF6 s33 sa21 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY K63
feature location: K63 TRAF6 s33 sa21 rs1 K63
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.70160900559296
comment: MODIFICATION_RESIDUE_NAME=K63

ncbitaxon 9544 5
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot D3ZXA5 113
type: UnificationXref
id: D3ZXA5
db: uniprot

uniprot Q90643 237
type: UnificationXref
id: Q90643
db: uniprot

IKKalpha s125 a183 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7B5L8 245
xref: PTHR24055:SF172
organism: Ornithorhynchus anatinus

LPS s106 a161 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LPS
stoichiometric coefficient: 1.0

uniprot H2Q5R2 41
type: UnificationXref
id: H2Q5R2
db: uniprot

TLR2,4,7
type: Protein
entity reference: TLR2,4,7

uniprot F7GLY8 191
type: UnificationXref
id: F7GLY8
db: uniprot

uniprot Q8CF89 184
type: UnificationXref
id: Q8CF89
db: uniprot

Complex (Poly I:C/TLR3)
type: Complex
component stoichiometry: Poly I:C s8 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
component: Poly I:C
component: TLR3
feature: COMPLEX BINDING FEATURE s77 a112 330
feature: COMPLEX BINDING FEATURE s77 a112 328
cellular location: cytosol

MODULATION
type: RelationshipTypeVocabulary

TAB1
type: ProteinReference
xref: P01365
standard name: Transforming growth factor-beta-activated kinase (TAK)-binding protein 1 (TAB1)
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.TAB1
comment: ENTITY_REFERENCE_NOTES=Long Name: Transforming growth factor-beta-activated kinase (TAK)-binding protein 1 (TAB1) Synonym: Synonym not specified Accession: P01365
member entity reference: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
member entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
member entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
member entity reference: RCG59826

TBK1
type: Protein
entity reference: TBK1
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa15 343
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9CZY3 264
type: UnificationXref
id: Q9CZY3
db: uniprot

UNKNOWN_TRANSITION_LEFT__TRAF6-RIGHT__TRAF6-_re43
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 414
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 413
left: TRAF6
interaction type: UNKNOWN_TRANSITION
right: TRAF6

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot Q62073 221
organism: Mus musculus

uniprot F1P630 240
type: UnificationXref
id: F1P630
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 5

00696
type: UnificationXref
id: MOD:00696
db: mod

TIR domain-containing adapter molecule 1
type: ProteinReference
xref: uniprot Q8IUC6 55
xref: PTHR47230:SF1
organism: Homo sapiens

uniprot P19419 35
type: UnificationXref
id: P19419
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 149
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TRIF-RIGHT__TRIF-_r101
controller: Complex (PAMP/TLR2,4,7)

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: uniprot B1NA68 185
xref: PTHR48013:SF15
organism: Danio rerio

PTHR46716:SF1
type: RelationshipXref
id: PTHR46716:SF1
db: PANTHER Family
relationship type: By Homology

Ubiquitin-conjugating enzyme E2 variant 1
type: ProteinReference
xref: uniprot Q9CZY3 264
organism: Mus musculus

IRAK1 s128 a92 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05627 139
organism: Mus musculus

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q9DGD9 253
organism: Danio rerio

uniprot F7HHC6 40
type: UnificationXref
id: F7HHC6
db: uniprot

uniprot Q16539 124
type: UnificationXref
id: Q16539
db: uniprot

Interferon regulatory factor 3
type: ProteinReference
xref: uniprot B6CJX6 234
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DWP4 31
organism: Macaca mulatta

STATE_TRANSITION_LEFT__MKK3-_ATP-RIGHT__MKK3-_ADP-_r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 488
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 486
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 489
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 487
left: MKK3
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: MKK3

TRAF family member-associated NF-kappa-B activator
type: ProteinReference
xref: uniprot P70347 132
organism: Mus musculus

A20
type: Protein
entity reference: A20
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ERK1
type: ProteinReference
xref: P01358
standard name: extracellular signal-regulated kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.ERK1
comment: ENTITY_REFERENCE_NOTES=Long Name: extracellular signal-regulated kinase 1 Synonym: ERK-1,ERK1,MAP kinase 1,MAPK1,p42 Accession: P01358
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Extracellular signal-regulated kinase 1

uniprot B6CJX6 234
type: UnificationXref
id: B6CJX6
db: uniprot

uniprot Q9N5Z3 92
type: UnificationXref
id: Q9N5Z3
db: uniprot

uniprot P36507 199
type: UnificationXref
id: P36507
db: uniprot

TANK
type: Protein
entity reference: TANK
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa16 345
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: uniprot Q9DGE1 126
xref: PTHR24055:SF110
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r90 439
type: Stoichiometry
physical entity: IRF3
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE2 128
organism: Danio rerio

uniprot Q91974 18
type: UnificationXref
id: Q91974
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GIS4 290
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6YAB9 119
organism: Monodelphis domestica

uniprot O14920 159
type: UnificationXref
id: O14920
db: uniprot

uniprot E2RML9 8
type: UnificationXref
id: E2RML9
db: uniprot

AP1
type: ProteinReference
xref: P01355
standard name: activator protein-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: activator protein-1 Synonym: AP1,activator protein-1,c-FOS,c-JUN Accession: P01355
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.AP1
member entity reference: Transcription factor AP-1
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit
member entity reference: Jun proto-oncogene

uniprot F7EI48 148
type: UnificationXref
id: F7EI48
db: uniprot

Poly I:C
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa5 329
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

IKKgamma
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__IKKbeta-_ATP-RIGHT__ADP-_IKKbeta-_r73
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 395
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 397
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 394
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 396
left: IKKbeta
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: IKKbeta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK6-_ATP-RIGHT__MKK6-_ADP-_r13
controller: TAK1

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot F6XT65 203
organism: Monodelphis domestica

TNF receptor-associated factor 6
type: ProteinReference
xref: uniprot B6CJY5 223
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot H2QS62 246
organism: Pan troglodytes

TAK1
type: ProteinReference
xref: P01370
standard name: transforming-growth factor beta-activated kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: transforming-growth factor beta-activated kinase 1 Synonym: MAP3K,MAPK kinase kinase,MAPKKK,TAK1,mitogen-activated protein kinase kinase kinase 7,transforming-growth factor beta-activated kinase Accession: P01370
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.TAK1
member entity reference: Mitogen-activated protein kinase kinase kinase 7
member entity reference: Uncharacterized protein

uniprot F7EKS7 259
type: UnificationXref
id: F7EKS7
db: uniprot

Toll-like receptor 7
type: ProteinReference
xref: uniprot A5H2Z9 69
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r90 440
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r90 441
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r90 442
type: Stoichiometry
physical entity: IRF3
stoichiometric coefficient: 1.0

uniprot A0A3S5ZPX3 194
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

TAB2
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa18 321
feature: TAB2 s28 sa18 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Toll-like receptor 2 type-2
type: ProteinReference
xref: uniprot Q9DGB6 88
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r93 438
type: Stoichiometry
physical entity: Complex (IKKepsilon/TBK1/ TANK)
stoichiometric coefficient: 1.0

uniprot B3Y674 74
type: UnificationXref
id: B3Y674
db: uniprot

PARTICIPANT STOICHIOMETRY r93 437
type: Stoichiometry
physical entity: TBK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r93 436
type: Stoichiometry
physical entity: IKKepsilon
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r93 435
type: Stoichiometry
physical entity: TANK
stoichiometric coefficient: 1.0

Ubc13
type: ProteinReference
xref: P01381
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.Ubc13
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Ubiquitin-conjugating enzyme E2 N
member entity reference: Predicted protein
member entity reference: UBE2NL isoform 1
member entity reference: Putative ubiquitin-conjugating enzyme E2 N-like
member entity reference: UBE2N isoform 2
member entity reference: Ubiquitin conjugating enzyme E2 N like (gene/pseudogene)
member entity reference: Ube2n protein
member entity reference: Ubiquitin-conjugating enzyme E2N-like

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__TIRAP-_MyD88-RIGHT__Complex__TIRAP_MyD88_-_r105
controller: Complex (PG, LP/TLR1,2,6)

TAB2
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa22 355
feature: TAB2 s36 sa22 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TAK1
type: Protein
entity reference: TAK1
feature: TAK1 s32 sa20 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa20 351
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MKK6 s29 a40 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6WV79 242
type: UnificationXref
id: F6WV79
db: uniprot

PARTICIPANT STOICHIOMETRY r21 482
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 483
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

MKK4
type: ProteinReference
xref: P01366
standard name: mitogen-activated protein kinase kinase 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.MKK4
comment: ENTITY_REFERENCE_NOTES=Long Name: mitogen-activated protein kinase kinase 4 Synonym: MKK4 Accession: P01366
member entity reference: Mitogen-activated protein kinase kinase 4A

TAK1
type: Protein
entity reference: TAK1
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa17 319
feature: TAK1 s27 sa17 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR22969:SF7
type: RelationshipXref
id: PTHR22969:SF7
db: PANTHER Family
relationship type: By Homology

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: uniprot H2QW34 158
xref: PTHR22969:SF7
organism: Pan troglodytes

Toll-interacting protein
type: ProteinReference
xref: uniprot Q9H0E2 279
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot P46734 193
organism: Homo sapiens

uniprot A2VDU3 213
type: UnificationXref
id: A2VDU3
db: uniprot

PARTICIPANT STOICHIOMETRY r21 485
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PTHR48177:SF1
type: RelationshipXref
id: PTHR48177:SF1
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r21 484
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

ERK2
type: ProteinReference
xref: P01356
standard name: extracellular signal-regulated kinase 2
comment: ENTITY_REFERENCE_NOTES=Long Name: extracellular signal-regulated kinase 2 Synonym: ERK2,p44 Accession: P01356
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.ERK2
member entity reference: Mitogen-activated protein kinase

MKK1 s50 a76 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9NR97 95
type: UnificationXref
id: Q9NR97
db: uniprot

Similar to TANK-binding kinase 1
type: ProteinReference
xref: uniprot D4A7D3 163
organism: Rattus norvegicus

TOLl (Drosophila) family
type: ProteinReference
xref: uniprot Q9N5Z3 92
organism: Caenorhabditis elegans

IRAK4
type: Protein
entity reference: IRAK4
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa28 347
feature: IRAK4 s64 sa28 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Toll-like receptor 1
type: ProteinReference
xref: uniprot Q9EPQ1 89
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2I3RV91 228
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TPI1 272
organism: Macaca mulatta

uniprot F6TKL3 241
type: UnificationXref
id: F6TKL3
db: uniprot

uniprot Q95122 233
type: UnificationXref
id: Q95122
db: uniprot

uniprot Q5ZK05 278
type: UnificationXref
id: Q5ZK05
db: uniprot

IKKepsilon
type: Protein
entity reference: IKKepsilon
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q8IUC6 55
type: UnificationXref
id: Q8IUC6
db: uniprot

ncbitaxon 6239 93
type: UnificationXref
id: 6239
db: ncbitaxon

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 257

HETERODIMER_ASSOCIATION_LEFT__TAB1-_TAK1-_TAB2-RIGHT__Complex__TAK1_TAB2__TAB1_-_r95
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 429
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 428
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 430
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 427
left: TAB2
left: TAB1
left: TAK1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TAK1/TAB2/ TAB1)

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 93

p38
type: Protein
entity reference: p38
feature: p38 s44 a66 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6Y4G8 243
type: UnificationXref
id: F6Y4G8
db: uniprot

uniprot Q9DGE2 128
type: UnificationXref
id: Q9DGE2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24419:SF1
xref: uniprot A0A1D5QFS2 44
organism: Macaca mulatta

TLR
type: ProteinReference
xref: P01346
standard name: Toll-like receptor 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
comment: ENTITY_REFERENCE_NOTES=Long Name: Toll-like receptor 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 Synonym: TLR Accession: P01346
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.RECEPTOR.TLR
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Toll-like receptor 6
member entity reference: Toll-like receptor 7
member entity reference: Toll-like receptor 2
member entity reference: Toll-like receptor 10
member entity reference: Toll-like receptor 2 type-2
member entity reference: Uncharacterized protein
member entity reference: Toll-like receptor 4
member entity reference: TLR10 isoform 2
member entity reference: TLR4 isoform 1
member entity reference: Protein toll
member entity reference: AGAP001004-PA
member entity reference: TLR7 isoform 1
member entity reference: Toll-like receptor 3
member entity reference: Toll-like receptor 8
member entity reference: Toll-like receptor 9
member entity reference: Toll-like receptor 1
member entity reference: 18 wheeler
member entity reference: TOLl (Drosophila) family
member entity reference: AGAP012387-PA
member entity reference: TLR3 isoform 1
member entity reference: Toll-like receptor 2 type-1
member entity reference: Toll-like receptor
member entity reference: TLR8 isoform 2

IRAK4 s3 a17 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TRAF6 s33 sa21 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.2718221599152955

JNK
type: Protein
entity reference: JNK
feature: JNK s38 a55 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E2RDL0 39
type: UnificationXref
id: E2RDL0
db: uniprot

IRF3 s100 a193 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r23 467
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 466
type: Stoichiometry
physical entity: MKK1
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HH32 291
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re44 412
type: Stoichiometry
physical entity: IRAK4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re44 411
type: Stoichiometry
physical entity: IRAK4
stoichiometric coefficient: 1.0

ERK1
type: Protein
entity reference: ERK1
feature: ERK1 s54 a80 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 148
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r23 469
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 468
type: Stoichiometry
physical entity: MKK1
stoichiometric coefficient: 1.0

uniprot A0A2I3TTS5 130
type: UnificationXref
id: A0A2I3TTS5
db: uniprot

Tollip s13 a22 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6RYL1 135
type: UnificationXref
id: F6RYL1
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot O09110 192
organism: Mus musculus

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

uniprot F6TPI1 272
type: UnificationXref
id: F6TPI1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TRAF6-_ATP-RIGHT__TRAF6-_ADP-_r37
controller: IRAK1

uniprot P31938 205
type: UnificationXref
id: P31938
db: uniprot

TAB2 s36 sa22 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot F7E9T3 23
type: UnificationXref
id: F7E9T3
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR23257:SF700
xref: uniprot Q9V3Q6 222
organism: Drosophila melanogaster

uniprot F6VNC5 103
type: UnificationXref
id: F6VNC5
db: uniprot

uniprot H2R5K3 144
type: UnificationXref
id: H2R5K3
db: uniprot

NFKB inhibitor alpha
type: ProteinReference
xref: uniprot E2RML9 8
xref: PTHR46680:SF1
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MyD88-RIGHT__MyD88-_r99
controller: Complex (TLR/PAMP)

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

GEO06356p1
type: ProteinReference
xref: uniprot Q9VRL1 265
organism: Drosophila melanogaster

Toll-like receptor 2
type: ProteinReference
xref: uniprot F1N720 75
organism: Bos taurus

ncbitaxon 6238 257
type: UnificationXref
id: 6238
db: ncbitaxon

MyD88 s82 a119 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MyD88
stoichiometric coefficient: 2.0

uniprot E1BKP4 164
type: UnificationXref
id: E1BKP4
db: uniprot

Complex (TAK1/TRAF6/ TAB2/TAB1/ MEKK1/ECSIT)
type: Complex
component stoichiometry: TAK1 s32 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRAF6 s33 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: TAB2 s36 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: MEKK1 s59 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: ECSIT s60 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: TAB1 s42 sa23 STOICHIOMETRY ID COMPLEX
component: TRAF6
component: MEKK1
component: TAB2
component: ECSIT
component: TAK1
component: TAB1
feature: COMPLEX BINDING FEATURE s152 a223 354
feature: COMPLEX BINDING FEATURE s152 a223 358
feature: COMPLEX BINDING FEATURE s152 a223 350
feature: COMPLEX BINDING FEATURE s152 a223 352
feature: COMPLEX BINDING FEATURE s152 a223 360
feature: COMPLEX BINDING FEATURE s152 a223 356
cellular location: cytosol

ERK1 s54 a80 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK2-_ATP-RIGHT__MKK2-_ADP-_r24
controller: TPL2

uniprot F6Q430 286
type: UnificationXref
id: F6Q430
db: uniprot

uniprot Q9VUN0 97
type: UnificationXref
id: Q9VUN0
db: uniprot

p38
type: Protein
entity reference: p38
feature: p38 s46 a68 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TLR
type: Protein
entity reference: TLR
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TLR4
type: Complex
component stoichiometry: TLR4 s22 sa13 STOICHIOMETRY ID COMPLEX
component: TLR4
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa13 339
cellular location: cytosol

IRAK4 s64 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IRAK4
stoichiometric coefficient: 1.0

TLR3
type: Complex
component stoichiometry: TLR3 s9 sa6 STOICHIOMETRY ID COMPLEX
component: TLR3
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa6 331
cellular location: cytosol

PG, LP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa9 325
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7H8X1 182
type: UnificationXref
id: F7H8X1
db: uniprot

uniprot Q92844 133
type: UnificationXref
id: Q92844
db: uniprot

ncbitaxon 9258 167
type: UnificationXref
id: 9258
db: ncbitaxon

Toll-like receptor 7
type: ProteinReference
xref: uniprot P58681 81
organism: Mus musculus

uniprot Q86XR7 53
type: UnificationXref
id: Q86XR7
db: uniprot

uniprot Q9QUN7 281
type: UnificationXref
id: Q9QUN7
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BKP4 164
organism: Bos taurus

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 248
xref: PTHR24055:SF222
organism: Homo sapiens

uniprot F6V332 118
type: UnificationXref
id: F6V332
db: uniprot

uniprot Q14164 227
type: UnificationXref
id: Q14164
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P45984 249
organism: Homo sapiens

uniprot A0A2I3TT58 180
type: UnificationXref
id: A0A2I3TT58
db: uniprot

IRF3 s139 a151 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F1PXD3 188
organism: Canis lupus familiaris

PTHR24419:SF1
type: RelationshipXref
id: PTHR24419:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P21580 109
type: UnificationXref
id: P21580
db: uniprot

uniprot J9P5W6 204
type: UnificationXref
id: J9P5W6
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot O14920 159
xref: PTHR22969:SF7
organism: Homo sapiens

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

uniprot Q60680 62
type: UnificationXref
id: Q60680
db: uniprot

CD14
type: ProteinReference
xref: P01373
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.CD14
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Monocyte differentiation antigen CD14
member entity reference: Uncharacterized protein

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK-_ATP-RIGHT__JNK-_ADP-_r17
controller: MKK3

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: uniprot P22366 267
organism: Mus musculus

MKK6 s30 a41 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GM52 226
organism: Macaca mulatta

TAB2 s36 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TAB2
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 120

TRIF
type: Protein
entity reference: TRIF
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9598 11
type: UnificationXref
id: 9598
db: ncbitaxon

TRIF
type: Complex
component stoichiometry: TRIF s80 a116 STOICHIOMETRY ID COMPLEX
component: TRIF
feature: ACTIVE 37
cellular location: cytosol

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__IkappaB_NF_kappaB_-_ATP-RIGHT__IkappaB-_ADP-_NF_kappaB-_r14
controller: Complex (IKKepsilon/TBK1/ TANK)

Toll like receptor adaptor molecule 1
type: ProteinReference
xref: PTHR47230:SF1
xref: uniprot H2R6G6 52
organism: Pan troglodytes

uniprot A0A1D5PXC6 238
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot E2R3R6 214
organism: Canis lupus familiaris

MyD88
type: ProteinReference
xref: P01377
standard name: myeloid differentiation factor 88
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.MyD88
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: myeloid differentiation factor 88 Synonym: DmMyD88 Accession: P01377
member entity reference: Myeloid differentiation primary response protein MyD88

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 244
xref: PTHR24055:SF222
organism: Macaca mulatta

TRANSCRIPTION
type: InteractionVocabulary

uniprot P0C8E4 220
type: UnificationXref
id: P0C8E4
db: uniprot

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: uniprot Q28DJ2 268
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r103 461
type: Stoichiometry
physical entity: Complex (IRAK4/IRAK1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r103 460
type: Stoichiometry
physical entity: IRAK1
stoichiometric coefficient: 1.0

TRAF6
type: ProteinReference
xref: P01371
standard name: tumor necrosis factor (TNF) receptor-associated factor 6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.TRAF6
comment: ENTITY_REFERENCE_NOTES=Long Name: tumor necrosis factor (TNF) receptor-associated factor 6 Synonym: TRAF6,dTRAF,tumor necrosis factor (TNF) receptor-associated factor 6 Accession: P01371
member entity reference: TNF receptor-associated factor 6
member entity reference: TNF receptor-associated factor

By Homology
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F6WV79 242
organism: Monodelphis domestica

Mitogen-activated protein kinase kinase kinase 8
type: ProteinReference
xref: uniprot Q63562 178
xref: PTHR48016:SF31
organism: Rattus norvegicus

MKK2
type: Protein
entity reference: MKK2
feature: MKK2 s53 a79 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IKKbeta s117 a172 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

UNKNOWN_TRANSITION_LEFT__IRAK1-RIGHT__IRAK1-_re45
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re45 406
participant stoichiometry: PARTICIPANT STOICHIOMETRY re45 405
left: IRAK1
interaction type: UNKNOWN_TRANSITION
right: IRAK1

MD-2
type: ProteinReference
xref: P01347
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.MD-2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Lymphocyte antigen 96
member entity reference: Uncharacterized protein
member entity reference: LY96 isoform 1

uniprot F1NYZ2 195
type: UnificationXref
id: F1NYZ2
db: uniprot

uniprot Q9V3Q6 222
type: UnificationXref
id: Q9V3Q6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK-_ATP-RIGHT__JNK-_ADP-_r17
controller: MKK6

Mitogen-activated protein kinase kinase kinase 8
type: ProteinReference
xref: PTHR48016:SF31
xref: uniprot Q07174 177
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r103 459
type: Stoichiometry
physical entity: IRAK4
stoichiometric coefficient: 1.0

uniprot P45983 248
type: UnificationXref
id: P45983
db: uniprot

IRAK4
type: Protein
entity reference: IRAK4
feature: IRAK4 s127 a3 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TAB1 s42 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TAB1
stoichiometric coefficient: 1.0

Toll-like receptor 2
type: ProteinReference
xref: uniprot B3Y613 70
organism: Pan troglodytes

Monocyte differentiation antigen CD14
type: ProteinReference
xref: uniprot P08571 230
organism: Homo sapiens

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot P47811 122
organism: Mus musculus

UNKNOWN_TRANSITION_LEFT__IRAK4-RIGHT__IRAK4-_re44
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 412
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 411
left: IRAK4
interaction type: UNKNOWN_TRANSITION
right: IRAK4

Toll-like receptor 2
type: ProteinReference
xref: uniprot B3Y618 71
organism: Macaca mulatta

IKKbeta
type: ProteinReference
xref: P01360
standard name: IkappaB_beta kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.IKK_beta_
comment: ENTITY_REFERENCE_NOTES=Long Name: IkappaB_beta kinase Synonym: IKK2 Accession: P01360
member entity reference: Inhibitor of nuclear factor kappa B kinase subunit beta
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6YI17 51
type: UnificationXref
id: F6YI17
db: uniprot

uniprot Q9EPQ1 89
type: UnificationXref
id: Q9EPQ1
db: uniprot

uniprot P08953 80
type: UnificationXref
id: P08953
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 150
organism: Rattus norvegicus

TANK s25 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TANK
stoichiometric coefficient: 1.0

TLR1,2,6
type: Protein
entity reference: TLR1,2,6

PARTICIPANT STOICHIOMETRY r37 410
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 409
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 408
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot H2Q1S6 175
type: UnificationXref
id: H2Q1S6
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot F7CCD5 216
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r37 407
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot F6SHC1 157
xref: PTHR22969:SF7
organism: Macaca mulatta

DISSOCIATION_LEFT__Complex__IRAK4_IRAK1_-_ATP-RIGHT__IRAK4-_IRAK1-_ADP-_r104
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 451
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 450
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 454
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 452
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 453
left: Complex (IRAK4/IRAK1)
left: ATP
interaction type: DISSOCIATION
right: ADP
right: IRAK1
right: IRAK4

IKKalpha
type: ProteinReference
xref: P01345
standard name: IkappaB_alpha Kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.IKK_alpha_
comment: ENTITY_REFERENCE_NOTES=Long Name: IkappaB_alpha Kinase Synonym: IKKalpha,IkappaB_alpha Kinase Accession: P01345
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha
member entity reference: Conserved helix-loop-helix ubiquitous kinase
member entity reference: Uncharacterized protein

TRAF family member associated NFKB activator
type: ProteinReference
xref: uniprot A0A2I3TTS5 130
organism: Pan troglodytes

Toll-like receptor 6
type: ProteinReference
xref: uniprot Q9Y2C9 98
organism: Homo sapiens

uniprot P51617 47
type: UnificationXref
id: P51617
db: uniprot

Ubiquitin-conjugating enzyme E2 variant 1
type: ProteinReference
xref: uniprot O45495 262
organism: Caenorhabditis elegans

Danio rerio
type: BioSource
xref: ncbitaxon 7955 127

uniprot Q5ZIF0 209
type: UnificationXref
id: Q5ZIF0
db: uniprot

PARTICIPANT STOICHIOMETRY r9 372
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

IkappaB s34 a48 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot D4A7D3 163
type: UnificationXref
id: D4A7D3
db: uniprot

uniprot F6S9S9 196
type: UnificationXref
id: F6S9S9
db: uniprot

Toll-interacting protein
type: ProteinReference
xref: uniprot A2RUW1 276
organism: Rattus norvegicus

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: uniprot Q99836 270
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UZJ7 77
organism: Macaca mulatta

Toll-like receptor
type: ProteinReference
xref: uniprot F6PP64 76
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r9 370
type: Stoichiometry
physical entity: Ubiquitin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 371
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

TLR s62 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TLR
stoichiometric coefficient: 2.0

Interleukin-1 receptor-associated kinase 1
type: ProteinReference
xref: PTHR24419:SF1
xref: uniprot Q62406 49
organism: Mus musculus

uniprot Q0VD16 208
type: UnificationXref
id: Q0VD16
db: uniprot

uniprot F6W7A5 287
type: UnificationXref
id: F6W7A5
db: uniprot

IRAKM
type: ProteinReference
xref: P01378
standard name: IL-1 receptor-associated kinase M
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.IRAKM
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: IL-1 receptor-associated kinase M Synonym: IRAKM Accession: P01378
member entity reference: Interleukin-1 receptor-associated kinase 3
member entity reference: Interleukin 1 receptor associated kinase 3
member entity reference: Uncharacterized protein

IRAK1 s128 sa146 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P53349 145
type: UnificationXref
id: P53349
db: uniprot

uniprot Q6Y1S1 269
type: UnificationXref
id: Q6Y1S1
db: uniprot

STATE_TRANSITION_LEFT__MKK4-_ATP-RIGHT__ADP-_MKK4-_r81
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 368
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 366
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 367
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 369
left: MKK4
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: MKK4

uniprot D4A7K4 38
type: UnificationXref
id: D4A7K4
db: uniprot

uniprot E2RNA9 58
type: UnificationXref
id: E2RNA9
db: uniprot

uniprot Q95KV1 63
type: UnificationXref
id: Q95KV1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK1-_ATP-RIGHT__ERK1-_ADP-_r25
controller: MKK1

Complex (TLR/PAMP)
type: Complex
component stoichiometry: PAMP s63 sa27 STOICHIOMETRY ID COMPLEX
component: TLR
component: PAMP
feature: COMPLEX BINDING FEATURE s155 a226 302
feature: COMPLEX BINDING FEATURE s155 a226 304
cellular location: cytosol

PTHR46680:SF1
type: RelationshipXref
id: PTHR46680:SF1
db: PANTHER Family
relationship type: By Homology

K63 TRAF6 s15 a113 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY K63
feature location: K63 TRAF6 s15 a113 rs1 K63
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.70160900559296
comment: MODIFICATION_RESIDUE_NAME=K63

UBE2NL isoform 1
type: ProteinReference
xref: uniprot H2R4I1 293
organism: Pan troglodytes

TLR2,4,7
type: ProteinReference
xref: P01351
standard name: Toll-like receptor 2, 4, 7
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.RECEPTOR.TLR2,4,7
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Toll-like receptor 7
member entity reference: Toll-like receptor 2
member entity reference: Toll-like receptor 2 type-2
member entity reference: Toll-like receptor 4
member entity reference: Uncharacterized protein
member entity reference: TLR4 isoform 1
member entity reference: Toll-like receptor 2 type-1
member entity reference: TLR7 isoform 1

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QPH3 64
organism: Macaca mulatta

uniprot B3Y618 71
type: UnificationXref
id: B3Y618
db: uniprot

TAK1
type: Protein
entity reference: TAK1
feature: TAK1 s43 a131 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Complex (IRAK4/IRAK1)
type: Complex
component stoichiometry: IRAK4 s64 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: IRAK1 s65 sa29 STOICHIOMETRY ID COMPLEX
component: IRAK1
component: IRAK4
feature: COMPLEX BINDING FEATURE s156 a229 348
feature: COMPLEX BINDING FEATURE s156 a229 346
cellular location: cytosol

uniprot H2RE03 260
type: UnificationXref
id: H2RE03
db: uniprot

uniprot F6XT65 203
type: UnificationXref
id: F6XT65
db: uniprot

uniprot Q9QX05 28
type: UnificationXref
id: Q9QX05
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__TANK-_IKKepsilon-_TBK1-RIGHT__Complex__IKKepsilon_TBK1__TANK_-_r93
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 435
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 438
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 436
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 437
left: TANK
left: IKKepsilon
left: TBK1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (IKKepsilon/TBK1/ TANK)

TLR3 isoform 1
type: ProteinReference
xref: uniprot B3Y620 30
organism: Pan troglodytes

STATE_TRANSITION_LEFT__MKK6-_ATP-RIGHT__MKK6-_ADP-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 388
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 389
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 387
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 386
left: ATP
left: MKK6
interaction type: STATE_TRANSITION
right: ADP
right: MKK6

TNF receptor-associated factor
type: ProteinReference
xref: uniprot H2Q3F3 224
organism: Pan troglodytes

Complex (TIRAP/MyD88)
type: Complex
component stoichiometry: MyD88 s67 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: TIRAP s66 sa30 STOICHIOMETRY ID COMPLEX
component: MyD88
component: TIRAP
feature: COMPLEX BINDING FEATURE s157 a232 362
feature: COMPLEX BINDING FEATURE s157 a232 364
feature: ACTIVE 37
cellular location: cytosol

TLR4 isoform 1
type: ProteinReference
xref: uniprot B3Y627 22
organism: Pan troglodytes

uniprot Q9QUK6 27
type: UnificationXref
id: Q9QUK6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot A0A1D5R1G4 4
organism: Macaca mulatta

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot F6PXH5 189
xref: PTHR48013:SF21
organism: Ornithorhynchus anatinus

uniprot A0A1D5R6X7 275
type: UnificationXref
id: A0A1D5R6X7
db: uniprot

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot A2VDU3 213
organism: Bos taurus

IRAK1
type: Protein
entity reference: IRAK1
feature: IRAK1 s128 sa146 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q02750 207
organism: Homo sapiens

uniprot Q6P023 141
type: UnificationXref
id: Q6P023
db: uniprot

uniprot P49186 250
type: UnificationXref
id: P49186
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4YET5 99
organism: Strongylocentrotus purpuratus

uniprot F1PYX5 285
type: UnificationXref
id: F1PYX5
db: uniprot

PTHR24365:SF537
type: RelationshipXref
id: PTHR24365:SF537
db: PANTHER Family
relationship type: By Homology

Stress-activated protein kinase JNK
type: ProteinReference
xref: uniprot P92208 252
xref: PTHR24055:SF341
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__p38-_ATP-RIGHT__p38-_ADP-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 483
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 482
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 485
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 484
left: ATP
left: p38
interaction type: STATE_TRANSITION
right: ADP
right: p38

uniprot H2QTT5 108
type: UnificationXref
id: H2QTT5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__IkappaB_NF_kappaB_-_ATP-RIGHT__IkappaB-_ADP-_NF_kappaB-_r14
controller: IKKalpha

Toll-like receptor 7
type: ProteinReference
xref: uniprot B3Y653 72
organism: Macaca mulatta

ERK2
type: Protein
entity reference: ERK2
feature: ACTIVE 37
feature: ERK2 s57 a82 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot Q9QY78 162
xref: PTHR22969:SF7
organism: Rattus norvegicus

Complex (MD-2/CD14/ TLR4)
type: Complex
component stoichiometry: LPS s106 a161 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 29STOICHIOMETRY ID COMPLEX
component stoichiometry: MD 2 s17 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: CD14 s20 sa12 STOICHIOMETRY ID COMPLEX
component: TLR4
component: LPS
component: CD14
component: MD-2
feature: COMPLEX BINDING FEATURE s135 a189 338
feature: COMPLEX BINDING FEATURE s135 a189 336
feature: COMPLEX BINDING FEATURE s135 a189 332
feature: COMPLEX BINDING FEATURE s135 a189 334
cellular location: cytosol

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 17

Ubiquitin-conjugating enzyme E2N-like
type: ProteinReference
xref: uniprot Q7T3F3 299
organism: Danio rerio

Protein CBR-UEV-1
type: ProteinReference
xref: uniprot A8XWI0 256
organism: Caenorhabditis briggsae

uniprot O60603 79
type: UnificationXref
id: O60603
db: uniprot

uniprot P05412 138
type: UnificationXref
id: P05412
db: uniprot

STATE_TRANSITION_LEFT__ATP-_TAK1-RIGHT__TAK1-_ADP-_r50
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 491
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 490
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 493
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 492
left: TAK1
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: TAK1

uniprot Q63746 16
type: UnificationXref
id: Q63746
db: uniprot

Ubiquitin-conjugating enzyme E2 N
type: ProteinReference
xref: uniprot Q0P5K3 297
organism: Bos taurus

IRAK1 s21 a4 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

TIRAP s66 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TIRAP
stoichiometric coefficient: 1.0

AP1
type: Protein
entity reference: AP1
feature: AP1 s40 a59 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

uniprot A7S6Q0 283
type: UnificationXref
id: A7S6Q0
db: uniprot

ncbitaxon 9615 9
type: UnificationXref
id: 9615
db: ncbitaxon

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
type: ProteinReference
xref: PTHR13832:SF533
xref: uniprot Q8CF89 184
organism: Mus musculus

Serine/threonine-protein kinase TBK1
type: ProteinReference
xref: uniprot F7DBZ3 168
organism: Macaca mulatta

uniprot Q63691 232
type: UnificationXref
id: Q63691
db: uniprot

IRAK1
type: Protein
entity reference: IRAK1
feature: IRAK1 s21 a4 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r104 451
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r104 452
type: Stoichiometry
physical entity: IRAK4
stoichiometric coefficient: 1.0

TAB1
type: Protein
entity reference: TAB1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r104 450
type: Stoichiometry
physical entity: Complex (IRAK4/IRAK1)
stoichiometric coefficient: 1.0

uniprot Q14653 236
type: UnificationXref
id: Q14653
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RE03 260
organism: Pan troglodytes

PG, LP s12 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PG, LP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TRIF-RIGHT__TRIF-_r101
controller: Complex (Poly I:C/TLR3)

PARTICIPANT STOICHIOMETRY r94 431
type: Stoichiometry
physical entity: TAB2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r94 432
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r104 453
type: Stoichiometry
physical entity: IRAK1
stoichiometric coefficient: 1.0

uniprot A0A1D5QKD3 202
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

PARTICIPANT STOICHIOMETRY r104 454
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q63746 16
organism: Rattus norvegicus

uniprot Q9Y616 274
type: UnificationXref
id: Q9Y616
db: uniprot

uniprot P21708 150
type: UnificationXref
id: P21708
db: uniprot

Interleukin-1 receptor-associated kinase 1
type: ProteinReference
xref: uniprot B2RYH5 45
xref: PTHR24419:SF1
organism: Rattus norvegicus

MKK1
type: Protein
entity reference: MKK1
feature: MKK1 s51 a77 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Toll-like receptor 10
type: ProteinReference
xref: uniprot B3Y674 74
organism: Macaca mulatta

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot O15111 61
xref: PTHR22969:SF13
organism: Homo sapiens

Monocyte differentiation antigen CD14
type: ProteinReference
xref: uniprot Q95122 233
organism: Bos taurus

uniprot A8XWI0 256
type: UnificationXref
id: A8XWI0
db: uniprot

TRAF6 s94 a28 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.2718221599152955

RCG22794, isoform CRA_a
type: ProteinReference
xref: uniprot D3ZXA5 113
xref: PTHR22662:SF0
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Genes-RIGHT__RNA-_re41
control type: ACTIVATION
controller: AP1

uniprot F7G1G8 289
type: UnificationXref
id: F7G1G8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK2-_ATP-RIGHT__ADP-_ERK2-_r26
controller: MKK2

PARTICIPANT STOICHIOMETRY r94 434
type: Stoichiometry
physical entity: TAB2
stoichiometric coefficient: 1.0

uniprot P25963 15
type: UnificationXref
id: P25963
db: uniprot

PTHR48016:SF31
type: RelationshipXref
id: PTHR48016:SF31
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r94 433
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

TLR10 isoform 2
type: ProteinReference
xref: uniprot B3Y669 73
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IKKbeta-_ATP-RIGHT__ADP-_IKKbeta-_r73
controller: TAK1

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: uniprot P25963 15
xref: PTHR46680:SF1
organism: Homo sapiens

TGF-beta activated kinase 1 (MAP3K7) binding protein 1
type: ProteinReference
xref: uniprot F1PLP7 181
xref: PTHR13832:SF533
organism: Canis lupus familiaris

PAMP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa27 305
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Mitogen-activated protein kinase kinase kinase 8
type: ProteinReference
xref: PTHR48016:SF31
xref: uniprot F6QKJ0 174
organism: Ornithorhynchus anatinus

IDA
type: EvidenceCodeVocabulary

STATE_TRANSITION_LEFT__Ubiquitin-_TRAF6-RIGHT__TRAF6-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 371
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 372
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 370
left: Ubiquitin
left: TRAF6
interaction type: STATE_TRANSITION
right: TRAF6

ERK2 s57 a82 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q5ZIF0 209
organism: Gallus gallus

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P17325 140
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r14 381
type: Stoichiometry
physical entity: Complex (IkappaB/NF-kappaB)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 382
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__IKKepsilon-RIGHT__IKKepsilon-_re42
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 417
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 418
left: IKKepsilon
interaction type: UNKNOWN_TRANSITION
right: IKKepsilon

PARTICIPANT STOICHIOMETRY r14 383
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 384
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 385
type: Stoichiometry
physical entity: NF-kappaB
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36507 199
organism: Homo sapiens

STATE_TRANSITION_LEFT__Elk1-_ATP-RIGHT__Elk1-_ADP-_r75
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 392
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 393
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 390
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 391
left: ATP
left: Elk1
interaction type: STATE_TRANSITION
right: ADP
right: Elk1

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot P36506 198
xref: PTHR48013:SF8
organism: Rattus norvegicus

Inhibitor of nuclear factor kappa-B kinase subunit epsilon
type: ProteinReference
xref: uniprot Q14164 227
organism: Homo sapiens

uniprot Q9QZ06 280
type: UnificationXref
id: Q9QZ06
db: uniprot

uniprot Q9DGB6 88
type: UnificationXref
id: Q9DGB6
db: uniprot

TIR domain-containing adapter molecule 2
type: ProteinReference
xref: PTHR22811:SF75
xref: uniprot B3Y699 50
organism: Pan troglodytes

TAB1
type: Protein
entity reference: TAB1
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa19 323
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

18 wheeler
type: ProteinReference
xref: uniprot A1ZBR2 67
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__IkappaB_NF_kappaB_-_ATP-RIGHT__IkappaB-_ADP-_NF_kappaB-_r14
controller: IKKbeta

uniprot P17325 140
type: UnificationXref
id: P17325
db: uniprot

uniprot E2RKR0 156
type: UnificationXref
id: E2RKR0
db: uniprot

uniprot Q9EQX9 301
type: UnificationXref
id: Q9EQX9
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: uniprot Q9Z1E3 20
xref: PTHR46680:SF1
organism: Mus musculus

Interleukin-1 receptor-associated kinase 4 isoform a
type: ProteinReference
xref: uniprot F7HHC6 40
organism: Macaca mulatta

uniprot Q9UHD2 170
type: UnificationXref
id: Q9UHD2
db: uniprot

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

Tollip s115 a157 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P41279 176
type: UnificationXref
id: P41279
db: uniprot

ncbitaxon 8364 136
type: UnificationXref
id: 8364
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G1G8 289
organism: Monodelphis domestica

ncbitaxon 7227 68
type: UnificationXref
id: 7227
db: ncbitaxon

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase TBK1
type: ProteinReference
xref: uniprot Q9WUN2 171
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r100 473
type: Stoichiometry
physical entity: IRAK4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r100 472
type: Stoichiometry
physical entity: IRAK4
stoichiometric coefficient: 1.0

K63 TRAF6 s94 a28 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY K63
feature location: K63 TRAF6 s94 a28 rs1 K63
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.70160900559296
comment: MODIFICATION_RESIDUE_NAME=K63

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7GLY8 191
organism: Macaca mulatta

Toll-interacting protein
type: ProteinReference
xref: uniprot Q5ZK05 278
organism: Gallus gallus

LY96 isoform 1
type: ProteinReference
xref: uniprot B3Y6A6 102
organism: Pan troglodytes

uniprot O77627 137
type: UnificationXref
id: O77627
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q63932 201
xref: PTHR48013:SF8
organism: Mus musculus

STATE_TRANSITION_LEFT__Tollip-_ATP-RIGHT__Tollip-_ADP-_r71
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 404
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 401
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 402
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 403
left: Tollip
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: Tollip

Monocyte differentiation antigen CD14
type: ProteinReference
xref: uniprot P10810 231
organism: Mus musculus

uniprot H9Z267 266
type: UnificationXref
id: H9Z267
db: uniprot

UBE2N isoform 2
type: ProteinReference
xref: uniprot H2Q6L8 292
organism: Pan troglodytes

GO GO:0005634 3
type: UnificationXref
id: GO:0005634
db: GO

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: uniprot Q91974 18
xref: PTHR46680:SF1
organism: Gallus gallus

MKK4 s123 a179 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot K7BYT0 197
type: UnificationXref
id: K7BYT0
db: uniprot

Putative ubiquitin-conjugating enzyme E2 N-like
type: ProteinReference
xref: uniprot Q5JXB2 298
organism: Homo sapiens

MyD88
type: Complex
component stoichiometry: MyD88 s82 a119 STOICHIOMETRY ID COMPLEX
component: MyD88
feature: ACTIVE 37
cellular location: cytosol

LPS
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s106 a161 333
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O15455 32
type: UnificationXref
id: O15455
db: uniprot

PAMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ubiquitin-conjugating enzyme E2 variant 1
type: ProteinReference
xref: uniprot K7DI65 261
organism: Pan troglodytes

TLR3
type: ProteinReference
xref: P01340
standard name: Toll-like receptor 3
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.RECEPTOR.TLR3
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: TLR3 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Toll-like receptor 3

uniprot F7FZL4 288
type: UnificationXref
id: F7FZL4
db: uniprot

AP1
type: Protein
entity reference: AP1
feature: AP1 s41 a60 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6X927 59
xref: PTHR22969:SF13
organism: Macaca mulatta

TRAF6
type: Protein
entity reference: TRAF6
feature: TRAF6 s91 a24 rs2
feature: K63 TRAF6 s91 a24 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Monocyte differentiation antigen CD14
type: ProteinReference
xref: uniprot B3Y6B8 229
organism: Macaca mulatta

NFKB inhibitor epsilon
type: ProteinReference
xref: uniprot H2QT35 12
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_TPL2-RIGHT__TPL2-_ADP-_r22
controller: ?

ERK2 s55 a81 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Tollip-_ATP-RIGHT__Tollip-_ADP-_r71
controller: IRAK4

TAK1 s32 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

TLR1,2,6
type: Complex
component stoichiometry: TLR1,2,6 s16 sa10 STOICHIOMETRY ID COMPLEX
component: TLR1,2,6
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa10 327
cellular location: cytosol

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 155
organism: Danio rerio

MKK4 s124 a180 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Genes-RIGHT__RNA-_re41
control type: ACTIVATION
controller: IRF3

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
type: ProteinReference
xref: PTHR13832:SF533
xref: uniprot F7H8X1 182
organism: Macaca mulatta

MEKK1
type: ProteinReference
xref: P01357
standard name: Mitogen-activated protein kinase kinase kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.MEKK1
comment: ENTITY_REFERENCE_NOTES=Long Name: mitogen-activated or extracellular signal-regulated kinase kinase kinase 1 Synonym: MAP3K,MEKK1 Accession: P01357
member entity reference: Mitogen-activated protein kinase kinase kinase 1
member entity reference: Uncharacterized protein

MODULATION
type: Control
xref: MODULATION
controlled: UNKNOWN_TRANSITION_LEFT__IRAK1-RIGHT__IRAK1-_re45
controller: IRAKM

Elk1 s119 a174 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 68

IRAK4
type: Protein
entity reference: IRAK4
feature: IRAK4 s127 sa145 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Complex (IKKepsilon/TBK1/ TANK)
type: Complex
component stoichiometry: IKKepsilon s23 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: TANK s25 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBK1 s24 sa15 STOICHIOMETRY ID COMPLEX
component: TBK1
component: TANK
component: IKKepsilon
feature: COMPLEX BINDING FEATURE s143 a203 340
feature: COMPLEX BINDING FEATURE s143 a203 344
feature: COMPLEX BINDING FEATURE s143 a203 342
feature: ACTIVE 37
cellular location: cytosol

Ubiquitin-conjugating enzyme E2 N
type: ProteinReference
xref: uniprot P61089 296
organism: Mus musculus

uniprot Q9WTU6 254
type: UnificationXref
id: Q9WTU6
db: uniprot

Ubiquitin-conjugating enzyme E2 N
type: ProteinReference
xref: uniprot P61088 295
organism: Homo sapiens

PTHR23257:SF700
type: RelationshipXref
id: PTHR23257:SF700
db: PANTHER Family
relationship type: By Homology

ncbitaxon 45351 284
type: UnificationXref
id: 45351
db: ncbitaxon

MKK3 s45 a67 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TANK binding kinase 1
type: ProteinReference
xref: uniprot E2R4G3 165
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r72 400
type: Stoichiometry
physical entity: IKKbeta
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A1D5PXC6 238
organism: Gallus gallus

uniprot P46734 193
type: UnificationXref
id: P46734
db: uniprot

TLR7 isoform 1
type: ProteinReference
xref: uniprot H2R4T7 78
organism: Pan troglodytes

uniprot B3Y699 50
type: UnificationXref
id: B3Y699
db: uniprot

TAK1 s27 sa17 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR24361:SF414
type: RelationshipXref
id: PTHR24361:SF414
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot P53349 145
organism: Mus musculus

uniprot B1NA68 185
type: UnificationXref
id: B1NA68
db: uniprot

PARTICIPANT STOICHIOMETRY r24 465
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 464
type: Stoichiometry
physical entity: MKK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 463
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 462
type: Stoichiometry
physical entity: MKK2
stoichiometric coefficient: 1.0

uniprot O45495 262
type: UnificationXref
id: O45495
db: uniprot

uniprot B1H230 187
type: UnificationXref
id: B1H230
db: uniprot

PTHR47230:SF1
type: RelationshipXref
id: PTHR47230:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F7BSY7 111
type: UnificationXref
id: F7BSY7
db: uniprot

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q66JE6 210
xref: PTHR48013:SF5
organism: Xenopus tropicalis

K63 TRAF6 s91 a24 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY K63
feature location: K63 TRAF6 s91 a24 rs1 K63
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.70160900559296
comment: MODIFICATION_RESIDUE_NAME=K63

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q6P023 141
xref: PTHR24055:SF203
organism: Danio rerio

uniprot E2RCV5 173
type: UnificationXref
id: E2RCV5
db: uniprot

MEKK1 s59 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MEKK1
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot P0C8E4 220
organism: Rattus norvegicus

PAMP s63 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PAMP
stoichiometric coefficient: 1.0

Toll-interacting protein
type: ProteinReference
xref: uniprot Q9QZ06 280
organism: Mus musculus

uniprot O09110 192
type: UnificationXref
id: O09110
db: uniprot

uniprot A0A2I3T3V8 66
type: UnificationXref
id: A0A2I3T3V8
db: uniprot

Toll-like receptor 4
type: ProteinReference
xref: uniprot Q9QX05 28
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F1P630 240
organism: Canis lupus familiaris

TRAF6 s33 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

uniprot H2QW34 158
type: UnificationXref
id: H2QW34
db: uniprot

MKK4
type: Protein
entity reference: MKK4
feature: MKK4 s123 a179 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 136

uniprot Q95NE7 125
type: UnificationXref
id: Q95NE7
db: uniprot

IRAK4 s64 sa28 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Interferon regulatory factor 3
type: ProteinReference
xref: uniprot P70671 235
organism: Mus musculus

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q9XT09 211
organism: Pan troglodytes

AGAP001004-PA
type: ProteinReference
xref: uniprot Q8WRE5 85
organism: Anopheles gambiae

uniprot Q63844 154
type: UnificationXref
id: Q63844
db: uniprot

uniprot Q66JE6 210
type: UnificationXref
id: Q66JE6
db: uniprot

AGAP012387-PA
type: ProteinReference
xref: uniprot Q7Q0C5 83
organism: Anopheles gambiae

STATE_TRANSITION_LEFT__AP1-_ATP-RIGHT__AP1-_ADP-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 375
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 376
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 373
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 374
left: AP1
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: AP1

PARTICIPANT STOICHIOMETRY r50 490
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Toll-like receptor 2
type: ProteinReference
xref: uniprot Q9QUN7 281
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r50 492
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r50 491
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

TLR3
type: Protein
entity reference: TLR3

PARTICIPANT STOICHIOMETRY r50 493
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

MKK4
type: Protein
entity reference: MKK4
feature: MKK4 s124 a180 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IKKepsilon
type: ProteinReference
xref: P01372
standard name: IkappaB_epsilon Kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: IkappaB_epsilon Kinase Synonym: IKK-epsilon Accession: P01372
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.IKK_epsilon_
member entity reference: Uncharacterized protein
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot H2R0G7 247
organism: Pan troglodytes

uniprot Q9NWZ3 43
type: UnificationXref
id: Q9NWZ3
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot F7H6S1 217
organism: Macaca mulatta

TAB2
type: Protein
feature: TAB2 s93 a130 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IRAK1
type: Protein
entity reference: IRAK1
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa29 349
feature: IRAK1 s65 sa29 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot O43318 219
organism: Homo sapiens

MODULATION
type: Control
xref: MODULATION
controlled: UNKNOWN_TRANSITION_LEFT__TRAF6-RIGHT__TRAF6-_re43
controller: A20

Elk1
type: Protein
entity reference: Elk1
feature: Elk1 s120 a175 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7165 84
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot F7HH32 291
type: UnificationXref
id: F7HH32
db: uniprot

uniprot H2RCY2 218
type: UnificationXref
id: H2RCY2
db: uniprot

uniprot P61089 296
type: UnificationXref
id: P61089
db: uniprot

uniprot Q9Y2C9 98
type: UnificationXref
id: Q9Y2C9
db: uniprot

Complex (IkappaB/NF-kappaB)
type: Complex
component stoichiometry: NF kappaB s7 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: IkappaB s6 sa3 STOICHIOMETRY ID COMPLEX
component: IkappaB
component: NF-kappaB
feature: COMPLEX BINDING FEATURE s35 a49 314
feature: COMPLEX BINDING FEATURE s35 a49 316
cellular location: cytosol

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P49186 250
xref: PTHR24055:SF172
organism: Rattus norvegicus

uniprot Q07174 177
type: UnificationXref
id: Q07174
db: uniprot

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot J9P5W6 204
xref: PTHR48013:SF5
organism: Canis lupus familiaris

MAP2K1 protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q0VD16 208
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6TKL3 241
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R6X7 275
organism: Macaca mulatta

STATE_TRANSITION_LEFT__PAMP-_TLR-RIGHT__Complex__TLR_PAMP_-_r98
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 421
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 420
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 419
left: TLR
left: PAMP
interaction type: STATE_TRANSITION
right: Complex (TLR/PAMP)

uniprot H2QZA3 46
type: UnificationXref
id: H2QZA3
db: uniprot

uniprot F6PXH5 189
type: UnificationXref
id: F6PXH5
db: uniprot

ncbitaxon 9031 19
type: UnificationXref
id: 9031
db: ncbitaxon

Predicted protein
type: ProteinReference
xref: uniprot A7S6Q0 283
organism: Nematostella vectensis

Toll-like receptor 2
type: ProteinReference
xref: uniprot O60603 79
organism: Homo sapiens

uniprot O15111 61
type: UnificationXref
id: O15111
db: uniprot

uniprot A0A0U1RRU5 179
type: UnificationXref
id: A0A0U1RRU5
db: uniprot

IRAK4
type: Protein
entity reference: IRAK4
feature: IRAK4 s3 a17 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7H9J1 143
type: UnificationXref
id: F7H9J1
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__IRAK4-_IRAK1-RIGHT__Complex__IRAK4_IRAK1_-_r103
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 461
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 460
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 459
left: IRAK4
left: IRAK1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (IRAK4/IRAK1)

MAP2K2 isoform 1
type: ProteinReference
xref: uniprot K7BYT0 197
xref: PTHR48013:SF8
organism: Pan troglodytes

IKKalpha
type: Protein
entity reference: IKKalpha
feature: IKKalpha s125 a183 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IRF3-_ATP-RIGHT__ADP-_IRF3-_r90
controller: Complex (IKKepsilon/TBK1/ TANK)

TNF receptor-associated factor 6
type: ProteinReference
xref: uniprot Q9Y4K3 225
organism: Homo sapiens

TPL2
type: Protein
entity reference: TPL2
feature: TPL2 s49 a75 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Tumor necrosis factor alpha-induced protein 3
type: ProteinReference
xref: uniprot F7DY40 107
organism: Macaca mulatta

…
type: Stoichiometry
physical entity: TLR1,2,6
stoichiometric coefficient: 2.0

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot P31938 205
organism: Mus musculus

uniprot E2R6T4 134
type: UnificationXref
id: E2R6T4
db: uniprot

uniprot Q9BQ95 112
type: UnificationXref
id: Q9BQ95
db: uniprot

IRAK1
type: ProteinReference
xref: P01343
comment: ENTITY_REFERENCE_NOTES=Long Name: IRAK1 Synonym: IL-1 receptor-associated kinase 1,IRAK1,Pelle Accession: P01343
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.IRAK1
member entity reference: Interleukin-1 receptor-associated kinase 1
member entity reference: IRAK1 isoform 1
member entity reference: Uncharacterized protein

uniprot F1N720 75
type: UnificationXref
id: F1N720
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IKKbeta-_ATP-RIGHT__ADP-_IKKbeta-_r73
controller: Complex (TAK1/TRAF6/ TAB2/TAB1/ MEKK1/ECSIT)

uniprot Q15750 183
type: UnificationXref
id: Q15750
db: uniprot

uniprot Q9XT09 211
type: UnificationXref
id: Q9XT09
db: uniprot

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

PAMP s10 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PAMP
stoichiometric coefficient: 1.0

uniprot A0A1D5R1G4 4
type: UnificationXref
id: A0A1D5R1G4
db: uniprot

Ubiquitin-conjugating enzyme E2 variant 1
type: ProteinReference
xref: uniprot A0A452DJ78 255
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 147
organism: Bos taurus

TRAF6 s91 a24 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.2718221599152955

uniprot Q9JHF9 104
type: UnificationXref
id: Q9JHF9
db: uniprot

MD 2 s17 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MD-2
stoichiometric coefficient: 1.0

Toll-like receptor 10
type: ProteinReference
xref: uniprot Q9BXR5 86
organism: Homo sapiens

Bos taurus
type: BioSource
xref: ncbitaxon 9913 26

UNKNOWN_TRANSITION
type: InteractionVocabulary

uniprot O00221 13
type: UnificationXref
id: O00221
db: uniprot

Ubiquitin-conjugating enzyme E2 variant 1
type: ProteinReference
xref: uniprot Q13404 263
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r25 455
type: Stoichiometry
physical entity: ERK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 456
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 457
type: Stoichiometry
physical entity: ERK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 458
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E9T3 23
organism: Macaca mulatta

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 167

PTHR48013:SF21
type: RelationshipXref
id: PTHR48013:SF21
db: PANTHER Family
relationship type: By Homology

uniprot F7GIS4 290
type: UnificationXref
id: F7GIS4
db: uniprot

Toll-like receptor 9
type: ProteinReference
xref: uniprot Q9EQU3 91
organism: Mus musculus

TLR4
type: Protein
entity reference: TLR4

uniprot Q0P5K3 297
type: UnificationXref
id: Q0P5K3
db: uniprot

ncbitaxon 10090 21
type: UnificationXref
id: 10090
db: ncbitaxon

TAB2 s28 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TAB2
stoichiometric coefficient: 1.0

uniprot H2Q6E2 169
type: UnificationXref
id: H2Q6E2
db: uniprot

uniprot F6SHC1 157
type: UnificationXref
id: F6SHC1
db: uniprot

uniprot F7DBZ3 168
type: UnificationXref
id: F7DBZ3
db: uniprot

Poly I:C s8 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Poly I:C
stoichiometric coefficient: 1.0

uniprot Q63932 201
type: UnificationXref
id: Q63932
db: uniprot

PARTICIPANT STOICHIOMETRY r81 369
type: Stoichiometry
physical entity: MKK4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r101 470
type: Stoichiometry
physical entity: TRIF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r101 471
type: Stoichiometry
physical entity: TRIF
stoichiometric coefficient: 2.0

ncbitaxon 13616 120
type: UnificationXref
id: 13616
db: ncbitaxon

Ubiquitin-conjugating enzyme E2 N
type: ProteinReference
xref: uniprot Q9EQX9 301
organism: Rattus norvegicus

Tumor necrosis factor alpha-induced protein 3
type: ProteinReference
xref: uniprot Q60769 110
organism: Mus musculus

STATE_TRANSITION_LEFT__MKK1-_ATP-RIGHT__MKK1-_ADP-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 469
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 467
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 466
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 468
left: MKK1
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: MKK1

MODULATION
type: Control
xref: MODULATION
controlled: UNKNOWN_TRANSITION_LEFT__IKKepsilon-RIGHT__IKKepsilon-_re42
controller: TRIF

uniprot Q62073 221
type: UnificationXref
id: Q62073
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Genes-RIGHT__RNA-_re41
control type: ACTIVATION
controller: Elk1

uniprot Q5JXB2 298
type: UnificationXref
id: Q5JXB2
db: uniprot

TLR1,2,6
type: ProteinReference
xref: P01380
standard name: Toll-like receptor 1, 2, 6
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.RECEPTOR.TLR1,2,6
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Toll-like receptor 2
member entity reference: Toll-like receptor 6
member entity reference: Toll-like receptor 2 type-1
member entity reference: Toll-like receptor 2 type-2
member entity reference: Toll-like receptor 1
member entity reference: Toll-like receptor

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 9

uniprot P10810 231
type: UnificationXref
id: P10810
db: uniprot

TRAF family member-associated NF-kappa-B activator isoform a
type: ProteinReference
xref: uniprot A0A1D5RCA1 129
organism: Macaca mulatta

Toll-like receptor 2 type-1
type: ProteinReference
xref: uniprot Q9DD78 87
organism: Gallus gallus

uniprot P36506 198
type: UnificationXref
id: P36506
db: uniprot

MKK2 s52 a78 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CD14
type: Protein
entity reference: CD14
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa12 337
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q6E9 273
type: UnificationXref
id: H2Q6E9
db: uniprot

PARTICIPANT STOICHIOMETRY r81 368
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r81 367
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

TAK1 s27 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

uniprot Q1HG70 200
type: UnificationXref
id: Q1HG70
db: uniprot

PARTICIPANT STOICHIOMETRY r81 366
type: Stoichiometry
physical entity: MKK4
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot H2RCY2 218
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR48177:SF1
xref: uniprot F1NKD9 258
organism: Gallus gallus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 19

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PYX5 285
organism: Canis lupus familiaris

MKK1 s51 a77 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9DGE1 126
type: UnificationXref
id: Q9DGE1
db: uniprot

MKK2
type: ProteinReference
xref: P01368
standard name: mitogen-activated protein kinase kinase 2
comment: ENTITY_REFERENCE_NOTES=Long Name: mitogen-activated protein kinase kinase 2 Synonym: MKK2 Accession: P01368
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.MKK2
member entity reference: MAP2K2 isoform 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase 2
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: Uncharacterized protein

uniprot Q28DJ2 268
type: UnificationXref
id: Q28DJ2
db: uniprot

p38 s44 a66 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MKK6
type: Protein
feature: MKK6 s30 a41 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E1B8P9 147
type: UnificationXref
id: E1B8P9
db: uniprot

TLR8 isoform 2
type: ProteinReference
xref: uniprot A0A2I3RDS7 65
organism: Pan troglodytes

STATE_TRANSITION_LEFT__MyD88-RIGHT__MyD88-_r99
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 416
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 415
left: MyD88
interaction type: STATE_TRANSITION
right: MyD88

Toll/interleukin-1 receptor domain-containing adapter protein
type: ProteinReference
xref: uniprot Q99JY1 115
xref: PTHR22662:SF0
organism: Mus musculus

HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TLR3
stoichiometric coefficient: 2.0

uniprot P92208 252
type: UnificationXref
id: P92208
db: uniprot

uniprot Q62925 146
type: UnificationXref
id: Q62925
db: uniprot

Ubiquitin conjugating enzyme E2 N like (gene/pseudogene)
type: ProteinReference
xref: uniprot F6Q430 286
organism: Ornithorhynchus anatinus

MAP3K8 isoform 1
type: ProteinReference
xref: uniprot H2Q1S6 175
xref: PTHR48016:SF31
organism: Pan troglodytes

STATE_TRANSITION_LEFT__ERK1-_ATP-RIGHT__ERK1-_ADP-_r25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 457
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 458
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 456
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 455
left: ERK1
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: ERK1

STATE_TRANSITION_LEFT__MKK2-_ATP-RIGHT__MKK2-_ADP-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 464
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 462
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 465
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 463
left: ATP
left: MKK2
interaction type: STATE_TRANSITION
right: ADP
right: MKK2

uniprot A0A452DJ78 255
type: UnificationXref
id: A0A452DJ78
db: uniprot

uniprot A0A3Q1MNG1 186
type: UnificationXref
id: A0A3Q1MNG1
db: uniprot

Toll-like receptor 7
type: ProteinReference
xref: uniprot Q9NYK1 96
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase 8
type: ProteinReference
xref: PTHR48016:SF31
xref: uniprot E2RCV5 173
organism: Canis lupus familiaris

uniprot F6U298 215
type: UnificationXref
id: F6U298
db: uniprot

STATE_TRANSITION_LEFT__IRAK4-RIGHT__IRAK4-_r100
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 473
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 472
left: IRAK4
interaction type: STATE_TRANSITION
right: IRAK4

uniprot H9FZA7 294
type: UnificationXref
id: H9FZA7
db: uniprot

Ubiquitin-conjugating enzyme E2 N
type: ProteinReference
xref: uniprot F6W7A5 287
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IRAK4-RIGHT__IRAK4-_r100
controller: MyD88

ERK1
type: Protein
entity reference: ERK1
feature: ERK1 s56 a83 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Toll-like receptor 6
type: ProteinReference
xref: uniprot Q9VUN0 97
organism: Drosophila melanogaster

uniprot Q9H0E2 279
type: UnificationXref
id: Q9H0E2
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P70618 123
xref: PTHR24055:SF110
organism: Rattus norvegicus

ncbitaxon 9913 26
type: UnificationXref
id: 9913
db: ncbitaxon

TRAF6 s15 a113 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.2718221599152955

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38-_ATP-RIGHT__p38-_ADP-_r21
controller: MKK3

uniprot Q95KV0 161
type: UnificationXref
id: Q95KV0
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Genes-RIGHT__RNA-_re41
control type: ACTIVATION
controller: NF-kappaB

MKK1
type: Protein
entity reference: MKK1
feature: MKK1 s50 a76 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Jun proto-oncogene
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot F6RYL1 135
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r85 480
type: Stoichiometry
physical entity: IKKalpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r85 481
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r85 479
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r99 415
type: Stoichiometry
physical entity: MyD88
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r99 416
type: Stoichiometry
physical entity: MyD88
stoichiometric coefficient: 2.0

uniprot A0A1D5NUC4 212
type: UnificationXref
id: A0A1D5NUC4
db: uniprot

uniprot Q8WRE5 85
type: UnificationXref
id: Q8WRE5
db: uniprot

PARTICIPANT STOICHIOMETRY r85 478
type: Stoichiometry
physical entity: IKKalpha
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Elk1-_ATP-RIGHT__Elk1-_ADP-_r75
controller: ERK2

PTHR22969:SF13
type: RelationshipXref
id: PTHR22969:SF13
db: PANTHER Family
relationship type: By Homology

uniprot Q9NR96 94
type: UnificationXref
id: Q9NR96
db: uniprot

IkappaB
type: ProteinReference
xref: P01338
standard name: Inhibitor of kappa light chain gene enhancer in B cells
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.I_kappa_B
comment: ENTITY_REFERENCE_NOTES=Long Name: IkappaB Synonym: Inhibitor nuclear factor-kappaB,cactus Accession: P01338
member entity reference: NF-kappa-B inhibitor alpha
member entity reference: NF-kappa-B inhibitor epsilon
member entity reference: NFKB inhibitor epsilon
member entity reference: NFKB inhibitor alpha
member entity reference: Uncharacterized protein

PARTICIPANT STOICHIOMETRY r22 475
type: Stoichiometry
physical entity: TPL2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 474
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 477
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 476
type: Stoichiometry
physical entity: TPL2
stoichiometric coefficient: 1.0

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot O88351 160
xref: PTHR22969:SF7
organism: Mus musculus

PTHR22662:SF0
type: RelationshipXref
id: PTHR22662:SF0
db: PANTHER Family
relationship type: By Homology

TAB2
type: Protein
feature: TAB2 s144 a207 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TANK-binding kinase 1
type: ProteinReference
xref: uniprot H2Q6E2 169
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r75 393
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot F1PLP7 181
type: UnificationXref
id: F1PLP7
db: uniprot

PARTICIPANT STOICHIOMETRY r75 392
type: Stoichiometry
physical entity: Elk1
stoichiometric coefficient: 1.0

Interleukin 1 receptor associated kinase 3
type: ProteinReference
xref: uniprot H2Q6E9 273
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r75 391
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r75 390
type: Stoichiometry
physical entity: Elk1
stoichiometric coefficient: 1.0

Toll-like receptor 4
type: ProteinReference
xref: uniprot Q6WCD5 25
organism: Bos taurus

uniprot B3Y613 70
type: UnificationXref
id: B3Y613
db: uniprot

Uev1A
type: Protein
entity reference: Uev1A
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa2 313
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E2R3R6 214
type: UnificationXref
id: E2R3R6
db: uniprot

Lymphocyte antigen 96
type: ProteinReference
xref: uniprot Q9JHF9 104
organism: Mus musculus

IkappaB
type: Protein
entity reference: IkappaB
feature: IkappaB s34 a48 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Complex__IkappaB_NF_kappaB_-_ATP-RIGHT__IkappaB-_ADP-_NF_kappaB-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 383
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 381
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 385
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 384
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 382
left: Complex (IkappaB/NF-kappaB)
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: IkappaB
right: NF-kappaB

uniprot A0A1D5RCA1 129
type: UnificationXref
id: A0A1D5RCA1
db: uniprot

TAB2 s93 a130 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot A0A2I3RV91 228
type: UnificationXref
id: A0A2I3RV91
db: uniprot

ncbitaxon 7668 100
type: UnificationXref
id: 7668
db: ncbitaxon

ECSIT s60 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ECSIT
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__JNK-_ATP-RIGHT__JNK-_ADP-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 380
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 377
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 378
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 379
left: JNK
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: JNK

TLR2,4,7
type: Complex
component stoichiometry: TLR2,4,7 s11 sa8 STOICHIOMETRY ID COMPLEX
component: TLR2,4,7
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa8 309
cellular location: cytosol

PARTICIPANT STOICHIOMETRY r95 430
type: Stoichiometry
physical entity: Complex (TAK1/TAB2/ TAB1)
stoichiometric coefficient: 1.0

uniprot F6YAB9 119
type: UnificationXref
id: F6YAB9
db: uniprot

Interleukin 1 receptor associated kinase 4
type: ProteinReference
xref: uniprot E2RDL0 39
organism: Canis lupus familiaris

uniprot F1M101 131
type: UnificationXref
id: F1M101
db: uniprot

IKKbeta s26 a35 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Elk1-_ATP-RIGHT__Elk1-_ADP-_r75
controller: ERK1

uniprot Q9Y6Y9 105
type: UnificationXref
id: Q9Y6Y9
db: uniprot

P01379
type: UnificationXref
id: P01379
db: PANTHER Pathway Component

A20
type: ProteinReference
xref: P01348
comment: ENTITY_REFERENCE_NOTES=Long Name: A20 Synonym: tumor necrosis factor, alpha-induced protein 3 Accession: P01348
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.A20
member entity reference: Tumor necrosis factor alpha-induced protein 3
member entity reference: TNF alpha induced protein 3

TAK1 s43 a131 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Toll/interleukin-1 receptor domain-containing adapter protein
type: ProteinReference
xref: uniprot P58753 114
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r95 429
type: Stoichiometry
physical entity: TAB2
stoichiometric coefficient: 1.0

TAK1 s32 sa20 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: uniprot Q6Y1S1 269
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__TIRAP-_MyD88-RIGHT__Complex__TIRAP_MyD88_-_r105
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 444
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 443
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 445
left: MyD88
left: TIRAP
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TIRAP/MyD88)

TNF alpha induced protein 3
type: ProteinReference
xref: uniprot E2QYU8 106
organism: Canis lupus familiaris

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 84

P01381
type: UnificationXref
id: P01381
db: PANTHER Pathway Component

P01380
type: UnificationXref
id: P01380
db: PANTHER Pathway Component

ERK1 s56 a83 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r95 427
type: Stoichiometry
physical entity: TAB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re45 406
type: Stoichiometry
physical entity: IRAK1
stoichiometric coefficient: 1.0

uniprot A0A1D5QFS2 44
type: UnificationXref
id: A0A1D5QFS2
db: uniprot

PARTICIPANT STOICHIOMETRY r95 428
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re45 405
type: Stoichiometry
physical entity: IRAK1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK3-_ATP-RIGHT__MKK3-_ADP-_r20
controller: TAK1

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot Q62925 146
xref: PTHR24361:SF414
organism: Rattus norvegicus

…
type: Stoichiometry
physical entity: TLR2,4,7
stoichiometric coefficient: 2.0

Elk1
type: Protein
entity reference: Elk1
feature: Elk1 s119 a174 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q60769 110
type: UnificationXref
id: Q60769
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot A0A1D5QKD3 202
xref: PTHR48013:SF5
organism: Macaca mulatta

Tollip
type: Protein
entity reference: Tollip
feature: Tollip s115 a157 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Tollip
type: Protein
entity reference: Tollip
feature: Tollip s13 a22 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__ATP-_TPL2-RIGHT__TPL2-_ADP-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 474
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 475
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 476
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 477
left: TPL2
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: TPL2

uniprot Q2LGB5 277
type: UnificationXref
id: Q2LGB5
db: uniprot

TAB1 s31 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TAB1
stoichiometric coefficient: 1.0

uniprot Q9DD78 87
type: UnificationXref
id: Q9DD78
db: uniprot

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

uniprot H2Q6L8 292
type: UnificationXref
id: H2Q6L8
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__TAK1_TAB2__TAB1_-_MEKK1-_ECSIT-_TRAF6-RIGHT__Complex__TAK1_TRAF6__TAB2_TAB1__MEKK1_ECSIT_-_r96
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 423
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 424
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 426
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 422
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 425
left: TRAF6
left: ECSIT
left: Complex (TAK1/TAB2/ TAB1)
left: MEKK1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TAK1/TRAF6/ TAB2/TAB1/ MEKK1/ECSIT)

PARTICIPANT STOICHIOMETRY r73 397
type: Stoichiometry
physical entity: IKKbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r73 396
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

P01357
type: UnificationXref
id: P01357
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r73 395
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

P01358
type: UnificationXref
id: P01358
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TAB2-_ATP-RIGHT__ADP-_TAB2-_r94
controller: IRAK1

PARTICIPANT STOICHIOMETRY r73 394
type: Stoichiometry
physical entity: IKKbeta
stoichiometric coefficient: 1.0

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05412 138
organism: Homo sapiens

Complex (PAMP/TLR2,4,7)
type: Complex
component stoichiometry: PAMP s10 sa7 STOICHIOMETRY ID COMPLEX
component: PAMP
component: TLR2,4,7
feature: COMPLEX BINDING FEATURE s104 a156 308
feature: COMPLEX BINDING FEATURE s104 a156 306
cellular location: cytosol

uniprot H2RA86 149
type: UnificationXref
id: H2RA86
db: uniprot

Serine/threonine-protein kinase TBK1
type: ProteinReference
xref: uniprot Q9UHD2 170
organism: Homo sapiens

P01361
type: UnificationXref
id: P01361
db: PANTHER Pathway Component

P01360
type: UnificationXref
id: P01360
db: PANTHER Pathway Component

P01367
type: UnificationXref
id: P01367
db: PANTHER Pathway Component

uniprot Q9BXR5 86
type: UnificationXref
id: Q9BXR5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H9J1 143
xref: PTHR24361:SF414
organism: Macaca mulatta

P01366
type: UnificationXref
id: P01366
db: PANTHER Pathway Component

IKKalpha s116 a171 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

P01365
type: UnificationXref
id: P01365
db: PANTHER Pathway Component

P01364
type: UnificationXref
id: P01364
db: PANTHER Pathway Component

TAB2 s28 sa18 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

TAB2 s144 a207 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Ubiquitin
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TIR domain-containing adapter molecule 2
type: ProteinReference
xref: PTHR22811:SF75
xref: uniprot Q86XR7 53
organism: Homo sapiens

Uev1A
type: ProteinReference
xref: P01376
standard name: Ubiquitin-conjugating enzyme E2 variant 1
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.Uev1A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ubiquitin-conjugating enzyme E2 variant 1
member entity reference: Uncharacterized protein
member entity reference: GEO06356p1
member entity reference: Protein CBR-UEV-1

P01368
type: UnificationXref
id: P01368
db: PANTHER Pathway Component

P01369
type: UnificationXref
id: P01369
db: PANTHER Pathway Component

uniprot A1ZBR2 67
type: UnificationXref
id: A1ZBR2
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot A0A2I3T4Q0 57
type: UnificationXref
id: A0A2I3T4Q0
db: uniprot

IKKepsilon s23 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IKKepsilon
stoichiometric coefficient: 1.0

TLR
type: Complex
component stoichiometry: TLR s62 sa26 STOICHIOMETRY ID COMPLEX
component: TLR
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa26 303
cellular location: cytosol

IRAK1
type: Protein
entity reference: IRAK1
feature: IRAK1 s128 a92 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P01372
type: UnificationXref
id: P01372
db: PANTHER Pathway Component

Ube2n protein
type: ProteinReference
xref: uniprot Q803J2 300
organism: Danio rerio

P01371
type: UnificationXref
id: P01371
db: PANTHER Pathway Component

P01374
type: UnificationXref
id: P01374
db: PANTHER Pathway Component

P01373
type: UnificationXref
id: P01373
db: PANTHER Pathway Component

P01376
type: UnificationXref
id: P01376
db: PANTHER Pathway Component

AP1 s40 a59 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

P01375
type: UnificationXref
id: P01375
db: PANTHER Pathway Component

P01378
type: UnificationXref
id: P01378
db: PANTHER Pathway Component

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

P01377
type: UnificationXref
id: P01377
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ubiquitin-_TRAF6-RIGHT__TRAF6-_r9
controller: Complex (Ubc13/Uev1A)

uniprot P70347 132
type: UnificationXref
id: P70347
db: uniprot

uniprot E2R4G3 165
type: UnificationXref
id: E2R4G3
db: uniprot

P01370
type: UnificationXref
id: P01370
db: PANTHER Pathway Component

P01339
type: UnificationXref
id: P01339
db: PANTHER Pathway Component

P01338
type: UnificationXref
id: P01338
db: PANTHER Pathway Component

MKK3
type: ProteinReference
xref: P01367
standard name: mitogen-activated protein kinase kinase 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.MKK3
comment: ENTITY_REFERENCE_NOTES=Long Name: mitogen-activated protein kinase kinase 3 Synonym: MKK3,mitogen-activated protein kinase kinase 3 Accession: P01367
member entity reference: Dual specificity mitogen-activated protein kinase kinase 3
member entity reference: Mitogen-activated protein kinase kinase 3
member entity reference: Uncharacterized protein
member entity reference: Map2k3 protein

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot F6U298 215
organism: Xenopus tropicalis

Toll-like receptor 6
type: ProteinReference
xref: uniprot Q9EPW9 90
organism: Mus musculus

Monocyte differentiation antigen CD14
type: ProteinReference
xref: uniprot Q63691 232
organism: Rattus norvegicus

uniprot H2Q3F3 224
type: UnificationXref
id: H2Q3F3
db: uniprot

PARTICIPANT STOICHIOMETRY r72 398
type: Stoichiometry
physical entity: IKKgamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 399
type: Stoichiometry
physical entity: IKKalpha
stoichiometric coefficient: 1.0

P01344
type: UnificationXref
id: P01344
db: PANTHER Pathway Component

uniprot Q01986 206
type: UnificationXref
id: Q01986
db: uniprot

P01345
type: UnificationXref
id: P01345
db: PANTHER Pathway Component

P01342
type: UnificationXref
id: P01342
db: PANTHER Pathway Component

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot O02812 121
organism: Canis lupus familiaris

P01343
type: UnificationXref
id: P01343
db: PANTHER Pathway Component

P01340
type: UnificationXref
id: P01340
db: PANTHER Pathway Component

P01341
type: UnificationXref
id: P01341
db: PANTHER Pathway Component

uniprot G3V926 60
type: UnificationXref
id: G3V926
db: uniprot

uniprot F1PXD3 188
type: UnificationXref
id: F1PXD3
db: uniprot

DISSOCIATION
type: InteractionVocabulary

NF kappaB s7 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NF-kappaB
stoichiometric coefficient: 1.0

Elk1
type: ProteinReference
xref: P01341
standard name: ELK1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.Elk1
comment: ENTITY_REFERENCE_NOTES=Long Name: ELK1 Synonym: ELK-1,ETS-like gene 1 Accession: P01341
member entity reference: ETS domain-containing protein Elk-1

CD14 s20 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD14
stoichiometric coefficient: 1.0

P01347
type: UnificationXref
id: P01347
db: PANTHER Pathway Component

HETERODIMER_ASSOCIATION_LEFT__IKKgamma-_IKKalpha-RIGHT__IKKbeta-_r72
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 398
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 400
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 399
left: IKKgamma
left: IKKalpha
interaction type: HETERODIMER_ASSOCIATION
right: IKKbeta

P01346
type: UnificationXref
id: P01346
db: PANTHER Pathway Component

P01349
type: UnificationXref
id: P01349
db: PANTHER Pathway Component

P01348
type: UnificationXref
id: P01348
db: PANTHER Pathway Component

Tollip
type: ProteinReference
xref: P01379
standard name: Toll-interacting protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Toll-interacting protein Synonym: Tollip Accession: P01379
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.Tollip
member entity reference: Uncharacterized protein
member entity reference: Toll-interacting protein

uniprot Q99JY1 115
type: UnificationXref
id: Q99JY1
db: uniprot

IRAKM
type: Protein
entity reference: IRAKM
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot B3Y669 73
type: UnificationXref
id: B3Y669
db: uniprot

ncbitaxon 237561 153
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot P22366 267
type: UnificationXref
id: P22366
db: uniprot

TANK
type: Protein
entity reference: TANK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q02750 207
type: UnificationXref
id: Q02750
db: uniprot

P01353
type: UnificationXref
id: P01353
db: PANTHER Pathway Component

P01355
type: UnificationXref
id: P01355
db: PANTHER Pathway Component

TRIF
type: Protein
entity reference: TRIF
feature: ACTIVE 37

P01356
type: UnificationXref
id: P01356
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK-_ATP-RIGHT__JNK-_ADP-_r17
controller: MKK4

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P19419 35
organism: Homo sapiens

TRAF family member-associated NF-kappa-B activator
type: ProteinReference
xref: uniprot Q92844 133
organism: Homo sapiens

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

P01350
type: UnificationXref
id: P01350
db: PANTHER Pathway Component

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 14

uniprot Q63562 178
type: UnificationXref
id: Q63562
db: uniprot

P01351
type: UnificationXref
id: P01351
db: PANTHER Pathway Component

Toll-like receptor 3
type: ProteinReference
xref: uniprot O15455 32
organism: Homo sapiens

JNK
type: ProteinReference
xref: P01375
standard name: c-jun N-terminal kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.JNK
comment: ENTITY_REFERENCE_NOTES=Long Name: c-jun N-terminal kinase Synonym: JNK,c-jun N-terminal kinase Accession: P01375
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Stress-activated protein kinase JNK
member entity reference: Mitogen-activated protein kinase 8

P01352
type: UnificationXref
id: P01352
db: PANTHER Pathway Component

uniprot O00206 24
type: UnificationXref
id: O00206
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 254
xref: PTHR24055:SF172
organism: Mus musculus

MODULATION
type: Control
xref: MODULATION
controlled: UNKNOWN_TRANSITION_LEFT__IRAK4-RIGHT__IRAK4-_re44
controller: IRAKM

TBK1
type: ProteinReference
xref: P01361
standard name: TANK-binding kinase 1
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.TBK1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: TANK-binding kinase 1 Synonym: TBK1 Accession: P01361
member entity reference: Serine/threonine-protein kinase TBK1
member entity reference: TANK binding kinase 1
member entity reference: Uncharacterized protein
member entity reference: Similar to TANK-binding kinase 1
member entity reference: TANK-binding kinase 1

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 8
type: ProteinReference
xref: PTHR48016:SF31
xref: uniprot A0A3Q1LK92 172
organism: Bos taurus

TGF-beta activated kinase 1 (MAP3K7) binding protein 1
type: ProteinReference
xref: PTHR13832:SF533
xref: uniprot A0A2I3TT58 180
organism: Pan troglodytes

uniprot H2R6G6 52
type: UnificationXref
id: H2R6G6
db: uniprot

uniprot B3Y6B8 229
type: UnificationXref
id: B3Y6B8
db: uniprot

TPL2
type: Protein
entity reference: TPL2
feature: TPL2 s48 a74 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NUC4 212
xref: PTHR46716:SF1
organism: Gallus gallus

ncbitaxon 9606 14
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q9NYK1 96
type: UnificationXref
id: Q9NYK1
db: uniprot

TRAF6
type: Protein
entity reference: TRAF6
feature: TRAF6 s33 sa21 rs2
feature: K63 TRAF6 s33 sa21 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa21 353
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q99836 270
type: UnificationXref
id: Q99836
db: uniprot

Interleukin-1 receptor-associated kinase 1
type: ProteinReference
xref: PTHR24419:SF1
xref: uniprot P51617 47
organism: Homo sapiens

MyD88 s67 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MyD88
stoichiometric coefficient: 1.0

MyD88
type: Protein
entity reference: MyD88
feature: ACTIVE 37

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6Y4G8 243
xref: PTHR24055:SF222
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__TRIF-RIGHT__TRIF-_r101
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 470
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 471
left: TRIF
interaction type: STATE_TRANSITION
right: TRIF

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 100

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot Q60680 62
organism: Mus musculus

uniprot Q9VRL1 265
type: UnificationXref
id: Q9VRL1
db: uniprot

uniprot F6QKJ0 174
type: UnificationXref
id: F6QKJ0
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot H2R5K3 144
organism: Pan troglodytes

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q1HG70 200
organism: Canis lupus familiaris

IKKepsilon
type: Protein
entity reference: IKKepsilon
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa14 341
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q2TY19 239
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

STATE_TRANSITION_LEFT__TRAF6-_ATP-RIGHT__TRAF6-_ADP-_r37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 407
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 410
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 409
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 408
left: ATP
left: TRAF6
interaction type: STATE_TRANSITION
right: ADP
right: TRAF6

NF-kappaB
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa4 317
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_TAK1-RIGHT__TAK1-_ADP-_r50
controller: IRAK1

uniprot O43318 219
type: UnificationXref
id: O43318
db: uniprot

uniprot F6TM15 166
type: UnificationXref
id: F6TM15
db: uniprot

TIRAP
type: ProteinReference
xref: P01350
standard name: TIR domain-containing adaptor protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.TIRAP
comment: ENTITY_REFERENCE_NOTES=Long Name: TIR domain-containing adaptor protein Synonym: MAL,MyD88-adaptor-like,TIRAP Accession: P01350
member entity reference: Toll/interleukin-1 receptor domain-containing adapter protein
member entity reference: RCG22794, isoform CRA_a

uniprot E2QYU8 106
type: UnificationXref
id: E2QYU8
db: uniprot

uniprot B3Y620 30
type: UnificationXref
id: B3Y620
db: uniprot

uniprot P05627 139
type: UnificationXref
id: P05627
db: uniprot

TRIF s80 a116 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRIF
stoichiometric coefficient: 2.0

Interferon regulatory factor 3
type: ProteinReference
xref: uniprot Q90643 237
organism: Gallus gallus

IRAK4
type: ProteinReference
xref: P01342
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Toll receptor signaling pathway.PROTEIN.GENERIC.IRAK4
comment: ENTITY_REFERENCE_NOTES=Long Name: IRAK4 Synonym: IL-1 receptor-associated kinase 4,IRAK4,Pelle Accession: P01342
member entity reference: Interleukin-1 receptor-associated kinase 4
member entity reference: Interleukin 1 receptor associated kinase 4
member entity reference: Interleukin-1 receptor-associated kinase 4 isoform a
member entity reference: IRAK4 isoform 2

MKK6
type: Protein
feature: MKK6 s29 a40 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F6S9S9 196
organism: Monodelphis domestica

?
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P47811 122
type: UnificationXref
id: P47811
db: uniprot

STATE_TRANSITION_LEFT__IRF3-_ATP-RIGHT__ADP-_IRF3-_r90
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 439
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 440
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 442
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 441
left: IRF3
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: IRF3

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6V332 118
xref: PTHR24055:SF110
organism: Macaca mulatta

TIRAP
type: Protein
entity reference: TIRAP
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r13 386
type: Stoichiometry
physical entity: MKK6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 387
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

TRANSCRIPTION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r98 420
type: Stoichiometry
physical entity: TLR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 388
type: Stoichiometry
physical entity: MKK6
stoichiometric coefficient: 1.0

TAK1
type: Protein
entity reference: TAK1
feature: TAK1 s96 a65 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P70671 235
type: UnificationXref
id: P70671
db: uniprot

PARTICIPANT STOICHIOMETRY r98 421
type: Stoichiometry
physical entity: Complex (TLR/PAMP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 389
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Ubc13
type: Protein
entity reference: Ubc13
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa1 311
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Toll-like receptor 4
type: ProteinReference
xref: uniprot O00206 24
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot A0A3Q1LTT9 117
organism: Bos taurus

TIRAP
type: Protein
entity reference: TIRAP
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa30 363
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION_LEFT__Genes-RIGHT__RNA-_re41
type: TemplateReaction
product: RNA
xref: TRANSCRIPTION
participant: RNA
participant: Genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot H2R4I1 293
type: UnificationXref
id: H2R4I1
db: uniprot

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

uniprot P41969 36
type: UnificationXref
id: P41969
db: uniprot

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7955 127
type: UnificationXref
id: 7955
db: ncbitaxon

PTHR22811:SF75
type: RelationshipXref
id: PTHR22811:SF75
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

ERK2
type: Protein
entity reference: ERK2
feature: ERK2 s55 a81 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P70618 123
type: UnificationXref
id: P70618
db: uniprot

uniprot Q9EPW9 90
type: UnificationXref
id: Q9EPW9
db: uniprot

Ubc13 s2 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ubc13
stoichiometric coefficient: 1.0

TIR domain-containing adapter molecule 2
type: ProteinReference
xref: uniprot Q8BJQ4 54
organism: Mus musculus

uniprot Q5A1D3 152
type: UnificationXref
id: Q5A1D3
db: uniprot

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot A0A2I3T4Q0 57
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r105 445
type: Stoichiometry
physical entity: Complex (TIRAP/MyD88)
stoichiometric coefficient: 1.0

uniprot F6PP64 76
type: UnificationXref
id: F6PP64
db: uniprot

uniprot F7GM52 226
type: UnificationXref
id: F7GM52
db: uniprot

ACTIVE 37
type: EntityFeature
comment: Active state

IRAK4 isoform 2
type: ProteinReference
xref: uniprot H2Q5R2 41
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r105 443
type: Stoichiometry
physical entity: TIRAP
stoichiometric coefficient: 1.0

PAMP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa7 307
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r105 444
type: Stoichiometry
physical entity: MyD88
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot A0A3S5ZPX3 194
organism: Bos taurus

uniprot A0A2I3RDS7 65
type: UnificationXref
id: A0A2I3RDS7
db: uniprot

IRF3
type: Protein
entity reference: IRF3
feature: IRF3 s100 a193 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Lymphocyte antigen 96
type: ProteinReference
xref: uniprot Q9Y6Y9 105
organism: Homo sapiens

MKK2
type: Protein
entity reference: MKK2
feature: MKK2 s52 a78 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 284

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7BD74 190
organism: Monodelphis domestica

uniprot A5H2Z9 69
type: UnificationXref
id: A5H2Z9
db: uniprot

uniprot Q9QY78 162
type: UnificationXref
id: Q9QY78
db: uniprot

uniprot Q7T3F3 299
type: UnificationXref
id: Q7T3F3
db: uniprot

HOMODIMER ID 29STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TLR4
stoichiometric coefficient: 2.0

uniprot Q9EQU3 91
type: UnificationXref
id: Q9EQU3
db: uniprot

RNA
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Toll-like receptor 4
type: ProteinReference
xref: uniprot Q9QUK6 27
organism: Mus musculus

uniprot F7B5L8 245
type: UnificationXref
id: F7B5L8
db: uniprot

uniprot H2R4T7 78
type: UnificationXref
id: H2R4T7
db: uniprot

NF-kappa-B inhibitor epsilon
type: ProteinReference
xref: uniprot O00221 13
organism: Homo sapiens

uniprot B6CJY5 223
type: UnificationXref
id: B6CJY5
db: uniprot

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

ECSIT
type: Protein
entity reference: ECSIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa25 361
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IKKbeta
type: Protein
entity reference: IKKbeta
feature: IKKbeta s26 a35 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7BD74 190
type: UnificationXref
id: F7BD74
db: uniprot

PARTICIPANT STOICHIOMETRY r98 419
type: Stoichiometry
physical entity: PAMP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK1-_ATP-RIGHT__MKK1-_ADP-_r23
controller: TPL2

TPL2 s48 a74 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

NFKB inhibitor alpha
type: ProteinReference
xref: uniprot H2Q867 10
xref: PTHR46680:SF1
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YI17 51
xref: PTHR47230:SF1
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r71 404
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 403
type: Stoichiometry
physical entity: Tollip
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 402
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 401
type: Stoichiometry
physical entity: Tollip
stoichiometric coefficient: 1.0

uniprot Q7ZVK8 155
type: UnificationXref
id: Q7ZVK8
db: uniprot

uniprot P45984 249
type: UnificationXref
id: P45984
db: uniprot

IRAK1 s65 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IRAK1
stoichiometric coefficient: 1.0

MyD88
type: Protein
entity reference: MyD88
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa31 365
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P58681 81
type: UnificationXref
id: P58681
db: uniprot

uniprot F7H6S1 217
type: UnificationXref
id: F7H6S1
db: uniprot

TLR1,2,6 s16 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TLR1,2,6
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r26 446
type: Stoichiometry
physical entity: ERK2
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY r26 449
type: Stoichiometry
physical entity: ERK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 448
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 447
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

IRF3
type: Protein
entity reference: IRF3
feature: IRF3 s139 a151 rs1
feature: ACTIVE 37
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TANK binding kinase 1
type: ProteinReference
xref: uniprot F6TM15 166
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q16539 124
organism: Homo sapiens

uniprot H2QS62 246
type: UnificationXref
id: H2QS62
db: uniprot

uniprot F7DWP4 31
type: UnificationXref
id: F7DWP4
db: uniprot

Ubiquitin-conjugating enzyme E2 N
type: ProteinReference
xref: uniprot H9FZA7 294
organism: Macaca mulatta

uniprot B3Y653 72
type: UnificationXref
id: B3Y653
db: uniprot

PARTICIPANT STOICHIOMETRY r17 380
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Candida albicans
type: BioSource
xref: ncbitaxon 237561 153

ncbitaxon 10116 17
type: UnificationXref
id: 10116
db: ncbitaxon

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: uniprot Q5A1D3 152
xref: PTHR24055:SF158
organism: Candida albicans

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BSY7 111
organism: Macaca mulatta

uniprot Q8BJQ4 54
type: UnificationXref
id: Q8BJQ4
db: uniprot

uniprot K7DI65 261
type: UnificationXref
id: K7DI65
db: uniprot

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FZL4 288
organism: Monodelphis domestica

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot E2R6T4 134
organism: Canis lupus familiaris

uniprot A0A3Q1LTT9 117
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

ECSIT
type: Protein
entity reference: ECSIT
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IkappaB s6 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

PARTICIPANT STOICHIOMETRY r17 379
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r17 378
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Toll-like receptor 9
type: ProteinReference
xref: uniprot Q9NR96 94
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r17 377
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

Toll-like receptor 8
type: ProteinReference
xref: uniprot Q9NR97 95
organism: Homo sapiens

uniprot P79996 251
type: UnificationXref
id: P79996
db: uniprot

IRAK1 isoform 1
type: ProteinReference
xref: uniprot H2QZA3 46
xref: PTHR24419:SF1
organism: Pan troglodytes

uniprot B2RYH5 45
type: UnificationXref
id: B2RYH5
db: uniprot

uniprot P58753 114
type: UnificationXref
id: P58753
db: uniprot

Toll-interacting protein
type: ProteinReference
xref: uniprot Q2LGB5 277
organism: Bos taurus

uniprot F6X927 59
type: UnificationXref
id: F6X927
db: uniprot

RCG59826
type: ProteinReference
xref: uniprot A0A0U1RRU5 179
xref: PTHR13832:SF533
organism: Rattus norvegicus

TLR2,4,7 s11 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TLR2,4,7
stoichiometric coefficient: 2.0

IKKalpha
type: Protein
entity reference: IKKalpha
feature: IKKalpha s116 a171 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN