Uncharacterized protein
type: ProteinReference
xref: uniprot F6SMC2 269
xref: PTHR10535:SF0
organism: Macaca mulatta

CBP P300 s159 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CBP/P300
stoichiometric coefficient: 1.0

TAF (TBP-associated transcription factor) family
type: ProteinReference
xref: uniprot Q9NEW8 208
organism: Caenorhabditis elegans

General transcription factor IIB
type: ProteinReference
xref: uniprot E2RPG1 450
organism: Canis lupus familiaris

uniprot P62875 296
type: UnificationXref
id: P62875
db: uniprot

RNA Polymerase II s180 a122 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.05

RNA Polymerase II s180 a122 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

uniprot Q9PT88 328
type: UnificationXref
id: Q9PT88
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P07278 83
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5REN8 122
organism: Macaca mulatta

Complex (TBP-associated factors/TBP/ TATA box Promoter/TFIIB/ TFIIA complex)
type: Complex
component stoichiometry: TBP associated factors s19 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: TATA box Promoter s25 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIA complex s32 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIB s27 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBP s24 sa18 STOICHIOMETRY ID COMPLEX
component: TATA box Promoter
component: TBP-associated factors
component: TFIIA complex
component: TFIIB
component: TBP
feature: COMPLEX BINDING FEATURE s59 a147 650
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 a147 661
feature: COMPLEX BINDING FEATURE s59 a147 652
feature: COMPLEX BINDING FEATURE s59 a147 658
feature: COMPLEX BINDING FEATURE s59 a147 656
feature: COMPLEX BINDING FEATURE s59 a147 654

RNA Polymerase II
type: Protein
entity reference: RNA Polymerase II
feature: RNA Polymerase II s183 a127 rs2
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s183 a127 597
feature: RNA Polymerase II s183 a127 rs4
feature: RNA Polymerase II s183 a127 rs3
feature: RNA Polymerase II s183 a127 rs1
comment: SPECIES_TYPE=PROTEIN

RNA Polymerase II s171 a217 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

uniprot P28148 534
type: UnificationXref
id: P28148
db: uniprot

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r87
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 759
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 760
left: PKA
interaction type: STATE_TRANSITION
right: PKA

Histone acetyltransferase HAC4
type: ProteinReference
xref: PTHR13808:SF30
xref: uniprot Q9LG11 239
organism: Arabidopsis thaliana

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot F6SGR6 267
organism: Ornithorhynchus anatinus

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: uniprot Q9NEX2 374
organism: Caenorhabditis elegans

uniprot O48890 282
type: UnificationXref
id: O48890
db: uniprot

uniprot Q5SQE1 425
type: UnificationXref
id: Q5SQE1
db: uniprot

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot Q7SAL1 318
organism: Neurospora crassa

Mus musculus
type: BioSource
xref: ncbitaxon 10090 33

TBP
type: Protein
entity reference: TBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa44 563
comment: SPECIES_TYPE=PROTEIN

uniprot F6S0M5 139
type: UnificationXref
id: F6S0M5
db: uniprot

ncbitaxon 188937 494
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot Q16594 173
type: UnificationXref
id: Q16594
db: uniprot

uniprot P29084 422
type: UnificationXref
id: P29084
db: uniprot

RNA Polymerase II s180 a122 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

CREB Homolog
type: ProteinReference
xref: uniprot Q4JFH9 39
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r84 710
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r84 711
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

ncbitaxon 69014 474
type: UnificationXref
id: 69014
db: ncbitaxon

uniprot Q9FIF4 373
type: UnificationXref
id: Q9FIF4
db: uniprot

TBP-associated factors
type: Protein
entity reference: TBP-associated factors
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa17 651
comment: SPECIES_TYPE=PROTEIN

General transcription factor IIF subunit 1
type: ProteinReference
xref: PTHR13011:SF0
xref: uniprot A0A1D5R7P4 378
organism: Macaca mulatta

TBP-associated factors
type: Protein
entity reference: TBP-associated factors
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa2 613
comment: SPECIES_TYPE=PROTEIN

uniprot Q61817 42
type: UnificationXref
id: Q61817
db: uniprot

uniprot A7SJZ7 446
type: UnificationXref
id: A7SJZ7
db: uniprot

Transcription initiation factor TFIID subunit 6
type: ProteinReference
xref: uniprot Q63801 187
organism: Rattus norvegicus

TAF4 isoform 2
type: ProteinReference
xref: PTHR15138:SF18
xref: uniprot H2REF4 156
organism: Pan troglodytes

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 102

RNA Polymerase II s180 a122 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

PRKAR1A isoform 12
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot H2R3M7 74
organism: Pan troglodytes

TFIIF
type: Protein
entity reference: TFIIF
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa22 689
comment: SPECIES_TYPE=PROTEIN

uniprot H2QN66 418
type: UnificationXref
id: H2QN66
db: uniprot

RNA polymerase II subunit F
type: ProteinReference
xref: uniprot E2RPD9 255
xref: PTHR10773:SF12
organism: Canis lupus familiaris

TATA-box-binding protein
type: ProteinReference
xref: uniprot P17871 530
xref: PTHR10126:SF42
organism: Schizosaccharomyces pombe

TBP s5 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

TFIIB s45 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIB
stoichiometric coefficient: 1.0

General transcription factor IIF subunit 1
type: ProteinReference
xref: uniprot Q05913 382
organism: Drosophila melanogaster

TATA box-binding protein-like protein 2
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q1JPY4 539
organism: Danio rerio

TATA box-binding protein-associated factor RNA polymerase I subunit C
type: ProteinReference
xref: uniprot Q6PDZ2 191
xref: PTHR15319:SF1
organism: Mus musculus

TBP s10 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

Transcription initiation factor TFIID subunit 7
type: ProteinReference
xref: uniprot Q9VHY5 213
organism: Drosophila melanogaster

General transcription factor IIH subunit 1
type: ProteinReference
xref: uniprot A0A2I3SS53 386
organism: Pan troglodytes

uniprot B7Q8S0 249
type: UnificationXref
id: B7Q8S0
db: uniprot

PTHR46004:SF1
type: RelationshipXref
id: PTHR46004:SF1
db: PANTHER Family
relationship type: By Homology

PTHR46004:SF2
type: RelationshipXref
id: PTHR46004:SF2
db: PANTHER Family
relationship type: By Homology

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot Q9VNZ3 330
organism: Drosophila melanogaster

General transcription factor IIH subunit 4
type: ProteinReference
xref: uniprot O70422 393
organism: Mus musculus

uniprot Q16514 172
type: UnificationXref
id: Q16514
db: uniprot

RNA Polymerase II s171 a217 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

uniprot Q9HR45 502
type: UnificationXref
id: Q9HR45
db: uniprot

CBP P300 s66 sa53 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CBP/P300
stoichiometric coefficient: 1.0

CBP P300 s153 sa49 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.11
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot H2R3M7 74
type: UnificationXref
id: H2R3M7
db: uniprot

uniprot Q93VP4 370
type: UnificationXref
id: Q93VP4
db: uniprot

Complex (TFIIEalpha/TFIIEalpha)
type: Complex
component stoichiometry: TFIIEalpha s3 sa3 STOICHIOMETRY ID COMPLEX
component: TFIIEalpha
feature: COMPLEX BINDING FEATURE s43 a113 586

uniprot Q6DIY4 545
type: UnificationXref
id: Q6DIY4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MME0 136
organism: Bos taurus

RNA Polymerase II s171 a217 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.05

TFIIA-alpha and beta-like factor
type: ProteinReference
xref: uniprot Q9UNN4 375
organism: Homo sapiens

ncbitaxon 9258 268
type: UnificationXref
id: 9258
db: ncbitaxon

DNA-directed RNA polymerase II subunit RPB3
type: ProteinReference
xref: uniprot F6VRF4 270
xref: PTHR11800:SF2
organism: Macaca mulatta

Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
type: ProteinReference
xref: uniprot F1QEC8 68
xref: PTHR11635:SF129
organism: Danio rerio

Complex (CREB/CBP/ P300)
type: Complex
component stoichiometry: CBP P300 s165 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 63STOICHIOMETRY ID COMPLEX
component stoichiometry: CRE s163 a257 STOICHIOMETRY ID COMPLEX
component: CREB
component: CBP/P300
component: CRE
feature: COMPLEX PARTICIPANT BINDING FEATURE s162 a267 669
feature: COMPLEX BINDING FEATURE s162 a267 664
feature: COMPLEX BINDING FEATURE s162 a267 666
feature: COMPLEX BINDING FEATURE s162 a267 662

TBP
type: Protein
entity reference: TBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa18 653
comment: SPECIES_TYPE=PROTEIN

uniprot Q5NC05 338
type: UnificationXref
id: Q5NC05
db: uniprot

RNA Polymerase II s171 a217 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

uniprot P32773 355
type: UnificationXref
id: P32773
db: uniprot

uniprot A5D6S6 243
type: UnificationXref
id: A5D6S6
db: uniprot

uniprot E1BV97 254
type: UnificationXref
id: E1BV97
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YKC3 524
organism: Macaca mulatta

uniprot P79011 223
type: UnificationXref
id: P79011
db: uniprot

Complex CREB CBP P300 s156 a268 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (CREB/CBP/ P300)
stoichiometric coefficient: 1.0

RNA Polymerase II s183 a127 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

uniprot Q01750 440
type: UnificationXref
id: Q01750
db: uniprot

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: uniprot O96881 221
xref: PTHR12716:SF8
organism: Drosophila melanogaster

GH11150p
type: ProteinReference
xref: uniprot O96880 420
organism: Drosophila melanogaster

TBP-related factor
type: ProteinReference
xref: uniprot Q27896 540
xref: PTHR10126:SF41
organism: Drosophila melanogaster

General transcription factor IIH subunit 4
type: ProteinReference
xref: uniprot Q6MG20 404
organism: Rattus norvegicus

uniprot Q7Q7C7 427
type: UnificationXref
id: Q7Q7C7
db: uniprot

uniprot O94424 436
type: UnificationXref
id: O94424
db: uniprot

uniprot F7HPQ9 150
type: UnificationXref
id: F7HPQ9
db: uniprot

PARTICIPANT STOICHIOMETRY r63 730
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZKX3 183
organism: Gallus gallus

uniprot H2PZC5 462
type: UnificationXref
id: H2PZC5
db: uniprot

PARTICIPANT STOICHIOMETRY r63 731
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Transcription initiation factor TFIID subunit 4
type: ProteinReference
xref: uniprot P47825 162
xref: PTHR15138:SF14
organism: Drosophila melanogaster

uniprot P41896 438
type: UnificationXref
id: P41896
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot Q7SXL3 550
type: UnificationXref
id: Q7SXL3
db: uniprot

Transcription initiation factor TFIID subunit 7
type: ProteinReference
xref: uniprot Q2HJG8 178
organism: Bos taurus

TBP s35 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

RNA Polymerase II s183 a127 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.05

uniprot O81098 284
type: UnificationXref
id: O81098
db: uniprot

CREB
type: Protein
entity reference: CREB
feature: ACTIVE 57
feature: CREB s164 sa37 rs1

TFIIE-alpha 1
type: ProteinReference
xref: uniprot Q93ZW3 428
organism: Arabidopsis thaliana

uniprot A0A2I3TKG9 344
type: UnificationXref
id: A0A2I3TKG9
db: uniprot

uniprot K7CNC1 281
type: UnificationXref
id: K7CNC1
db: uniprot

Transcription initiation factor TFIID subunit 11
type: ProteinReference
xref: uniprot P49906 166
organism: Drosophila melanogaster

Transcription initiation factor TFIID subunit 12
type: ProteinReference
xref: uniprot P49905 165
organism: Drosophila melanogaster

GTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P49848 164
type: UnificationXref
id: P49848
db: uniprot

Transcription initiation factor TFIID subunit 11
type: ProteinReference
xref: uniprot Q15544 169
organism: Homo sapiens

Transcription initiation factor TFIID subunit 7
type: ProteinReference
xref: uniprot Q15545 170
organism: Homo sapiens

uniprot Q6NLH0 311
type: UnificationXref
id: Q6NLH0
db: uniprot

Transcription initiation factor TFIID subunit 9B
type: ProteinReference
xref: uniprot Q9HBM6 205
organism: Homo sapiens

uniprot B9EJ57 332
type: UnificationXref
id: B9EJ57
db: uniprot

uniprot Q28DH2 541
type: UnificationXref
id: Q28DH2
db: uniprot

Complex TBP TBP associated factors s177 a125 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (TBP/TBP-associated factors)
stoichiometric coefficient: 1.0

uniprot Q9LG11 239
type: UnificationXref
id: Q9LG11
db: uniprot

s160
type: Complex
component stoichiometry: Complex CREB CBP P300 s156 a268 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex TBP associated factors TBP TATA box Promoter TFIIA complex s55 a141 STOICHIOMETRY ID COMPLEX
component: Complex (CREB/CBP/ P300)
component: Complex (TBP-associated factors/TBP/ TATA box Promoter/TFIIA complex)
feature: COMPLEX BINDING FEATURE s160 csa20 686
feature: COMPLEX BINDING FEATURE s160 csa20 678

RNA Polymerase II s183 a127 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

uniprot Q9VC49 329
type: UnificationXref
id: Q9VC49
db: uniprot

uniprot A7UTV1 126
type: UnificationXref
id: A7UTV1
db: uniprot

uniprot Q3UAW9 480
type: UnificationXref
id: Q3UAW9
db: uniprot

uniprot Q9HHK5 500
type: UnificationXref
id: Q9HHK5
db: uniprot

uniprot Q7S8Z5 317
type: UnificationXref
id: Q7S8Z5
db: uniprot

uniprot P12849 89
type: UnificationXref
id: P12849
db: uniprot

TATA box-binding protein-like protein 1
type: ProteinReference
xref: uniprot Q9YGV8 555
xref: PTHR10126:SF55
organism: Gallus gallus

TAF6 isoform 6
type: ProteinReference
xref: uniprot A0A2I3REX6 123
organism: Pan troglodytes

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: uniprot Q0DLD3 360
organism: Oryza sativa

uniprot P15337 31
type: UnificationXref
id: P15337
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot Q01386 101
xref: PTHR11635:SF152
organism: Neurospora crassa

TFIIA complex s18 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIA complex
stoichiometric coefficient: 1.0

General transcription factor II E, polypeptide 1 (Alpha subunit)
type: ProteinReference
xref: PTHR13097:SF7
xref: uniprot G3V992 416
organism: Rattus norvegicus

uniprot A0A2I3REX6 123
type: UnificationXref
id: A0A2I3REX6
db: uniprot

General transcription factor IIF subunit 2
type: ProteinReference
xref: uniprot H9ERZ5 435
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PMC9 456
organism: Monodelphis domestica

uniprot H2RER5 75
type: UnificationXref
id: H2RER5
db: uniprot

TATA-box-binding protein
type: ProteinReference
xref: uniprot P20227 532
xref: PTHR10126:SF42
organism: Drosophila melanogaster

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot P20226 531
organism: Homo sapiens

TFIIA complex s64 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIA complex
stoichiometric coefficient: 1.0

Cyclic AMP-responsive element-binding protein 1
type: ProteinReference
xref: uniprot P15337 31
xref: PTHR45879:SF1
organism: Rattus norvegicus

Complex TBP associated factors TBP TATA box Promoter TFIIB TFIIA complex s59 a147 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (TBP-associated factors/TBP/ TATA box Promoter/TFIIB/ TFIIA complex)
stoichiometric coefficient: 1.0

CBP/P300
type: Protein
entity reference: CBP/P300
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa36 627
feature: CBP P300 s54 sa36 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot W4Y5K3 509
type: UnificationXref
id: W4Y5K3
db: uniprot

uniprot Q923G2 323
type: UnificationXref
id: Q923G2
db: uniprot

Transcription initiation factor TFIID subunit 6
type: ProteinReference
xref: uniprot O74462 159
organism: Schizosaccharomyces pombe

uniprot E2QVZ3 130
type: UnificationXref
id: E2QVZ3
db: uniprot

uniprot F7E905 231
type: UnificationXref
id: F7E905
db: uniprot

GTF2E1 isoform 2
type: ProteinReference
xref: PTHR13097:SF7
xref: uniprot H2QN66 418
organism: Pan troglodytes

uniprot Q6DDA6 309
type: UnificationXref
id: Q6DDA6
db: uniprot

uniprot C3Y645 251
type: UnificationXref
id: C3Y645
db: uniprot

uniprot P62915 475
type: UnificationXref
id: P62915
db: uniprot

uniprot Q7JZF5 312
type: UnificationXref
id: Q7JZF5
db: uniprot

Prkar1a protein
type: ProteinReference
xref: uniprot Q5I0F6 108
xref: PTHR11635:SF129
organism: Danio rerio

Transcription initiation factor TFIID subunit 11
type: ProteinReference
xref: uniprot A0A1D5QA17 121
organism: Macaca mulatta

uniprot P31324 95
type: UnificationXref
id: P31324
db: uniprot

CREB binding protein
type: ProteinReference
xref: uniprot F1PY87 228
xref: PTHR13808:SF34
organism: Canis lupus familiaris

uniprot E2RFB9 132
type: UnificationXref
id: E2RFB9
db: uniprot

DNA-directed RNA polymerases II, IV and V subunit 9A
type: ProteinReference
xref: uniprot Q6NLH0 311
organism: Arabidopsis thaliana

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot F6Q503 69
xref: PTHR11635:SF156
organism: Macaca mulatta

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: PTHR12716:SF8
xref: uniprot D3ZCP9 411
organism: Rattus norvegicus

TATA box Promoter gene termination s182 a126 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TATA box Promoter gene termination
stoichiometric coefficient: 1.0

PTHR15138:SF14
type: RelationshipXref
id: PTHR15138:SF14
db: PANTHER Family
relationship type: By Homology

PTHR15138:SF18
type: RelationshipXref
id: PTHR15138:SF18
db: PANTHER Family
relationship type: By Homology

Protein kinase A regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot Q385V6 104
organism: Trypanosoma brucei

RNA Polymerase II s183 a127 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

PARTICIPANT STOICHIOMETRY r66 719
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r66 718
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPQ7 149
organism: Macaca mulatta

BRF2 isoform 1
type: ProteinReference
xref: uniprot H2QW11 465
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPQ9 150
organism: Macaca mulatta

TFIIA-L3
type: ProteinReference
xref: PTHR12694:SF15
xref: uniprot Q9FIF4 373
organism: Arabidopsis thaliana

uniprot Q7QB20 489
type: UnificationXref
id: Q7QB20
db: uniprot

TATA box-binding protein-associated factor RNA polymerase I subunit C
type: ProteinReference
xref: uniprot Q15572 171
xref: PTHR15319:SF1
organism: Homo sapiens

uniprot P61218 294
type: UnificationXref
id: P61218
db: uniprot

RNA Polymerase II
type: Protein
entity reference: RNA Polymerase II
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s171 a217 705
feature: RNA Polymerase II s171 a217 rs3
feature: RNA Polymerase II s171 a217 rs4
feature: RNA Polymerase II s171 a217 rs2
feature: RNA Polymerase II s171 a217 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot B3RID1 247
type: UnificationXref
id: B3RID1
db: uniprot

uniprot H2Q9J2 351
type: UnificationXref
id: H2Q9J2
db: uniprot

uniprot H2QBM1 152
type: UnificationXref
id: H2QBM1
db: uniprot

uniprot A0A2I3R9X3 241
type: UnificationXref
id: A0A2I3R9X3
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__TFIIE_beta_TFIIE_beta_-_Complex__TFIIEalpha_TFIIEalpha_-RIGHT__TFIIE-_r41
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 743
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 742
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 741
left: Complex (TFIIEalpha/TFIIEalpha)
left: Complex (TFIIE_beta/TFIIE_beta)
interaction type: HETERODIMER_ASSOCIATION
right: TFIIE

cAMP responsive element binding protein 3 like 1
type: ProteinReference
xref: PTHR46004:SF1
xref: uniprot E2RLD6 13
organism: Canis lupus familiaris

uniprot A8X861 512
type: UnificationXref
id: A8X861
db: uniprot

uniprot P13393 529
type: UnificationXref
id: P13393
db: uniprot

TBP associated factors s9 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP-associated factors
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot Q7SG05 367
xref: PTHR12694:SF8
organism: Neurospora crassa

Cyclic AMP-responsive element-binding protein 3-like protein 3
type: ProteinReference
xref: PTHR45996:SF1
xref: uniprot Q5FVM5 40
organism: Rattus norvegicus

DNA-directed RNA polymerase II subunit 4
type: ProteinReference
xref: uniprot O48890 282
organism: Arabidopsis thaliana

PTHR46469:SF1
type: RelationshipXref
id: PTHR46469:SF1
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot W4YRI6 119
xref: PTHR11635:SF162
organism: Strongylocentrotus purpuratus

uniprot Q5TR07 426
type: UnificationXref
id: Q5TR07
db: uniprot

TATA-box-binding protein
type: ProteinReference
xref: uniprot P26355 533
xref: PTHR10126:SF42
organism: Dictyostelium discoideum

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: uniprot O74948 354
organism: Schizosaccharomyces pombe

uniprot P27699 32
type: UnificationXref
id: P27699
db: uniprot

uniprot P32780 394
type: UnificationXref
id: P32780
db: uniprot

uniprot F7FD05 21
type: UnificationXref
id: F7FD05
db: uniprot

TATA box-binding protein-like protein 1
type: ProteinReference
xref: PTHR10126:SF55
xref: uniprot Q5U385 543
organism: Danio rerio

ncbitaxon 237631 99
type: UnificationXref
id: 237631
db: ncbitaxon

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46338:SF1
xref: uniprot O94706 160
organism: Schizosaccharomyces pombe

CREB
type: Protein
entity reference: CREB
feature: ACTIVE 57
feature: CREB s103 a237 rs1

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 516

Transcription initiation factor IIB 2
type: ProteinReference
xref: uniprot P58109 473
organism: Thermococcus kodakaraensis

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

CBP/P300
type: Protein
entity reference: CBP/P300
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s159 sa40 685
feature: CBP P300 s159 sa40 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot F7F9P9 460
type: UnificationXref
id: F7F9P9
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot P00514 79
organism: Bos taurus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P00515 80
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MS65 124
organism: Bos taurus

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 16

uniprot P20434 291
type: UnificationXref
id: P20434
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E5W7 145
organism: Macaca mulatta

uniprot Q7Q2H6 316
type: UnificationXref
id: Q7Q2H6
db: uniprot

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: uniprot Q28J24 177
xref: PTHR46469:SF1
organism: Xenopus tropicalis

uniprot F6SGR6 267
type: UnificationXref
id: F6SGR6
db: uniprot

uniprot H2REF4 156
type: UnificationXref
id: H2REF4
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P05987 81
organism: Dictyostelium discoideum

uniprot Q3ZBP7 180
type: UnificationXref
id: Q3ZBP7
db: uniprot

cAMP responsive element binding protein 3 like 1
type: ProteinReference
xref: uniprot A0A3Q1MJS5 8
xref: PTHR46004:SF1
organism: Bos taurus

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: PTHR10966:SF0
xref: uniprot Q7QA87 365
organism: Anopheles gambiae

TFIIA complex s40 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIA complex
stoichiometric coefficient: 1.0

uniprot F2Z4J6 452
type: UnificationXref
id: F2Z4J6
db: uniprot

Cyclic AMP-responsive element-binding protein 3-like protein 1
type: ProteinReference
xref: PTHR46004:SF1
xref: uniprot Q96BA8 53
organism: Homo sapiens

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: uniprot Q503H9 362
organism: Danio rerio

uniprot Q9W5B9 377
type: UnificationXref
id: Q9W5B9
db: uniprot

uniprot F7F0J5 525
type: UnificationXref
id: F7F0J5
db: uniprot

uniprot A7SLP4 244
type: UnificationXref
id: A7SLP4
db: uniprot

AGAP004940-PA
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot Q7PPI8 114
organism: Anopheles gambiae

uniprot F7FZ67 146
type: UnificationXref
id: F7FZ67
db: uniprot

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

ncbitaxon 10090 33
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot O94706 160
type: UnificationXref
id: O94706
db: uniprot

Cilia- and flagella-associated protein 20
type: ProteinReference
xref: uniprot Q9Y6A4 508
organism: Homo sapiens

uniprot F7GSG6 148
type: UnificationXref
id: F7GSG6
db: uniprot

uniprot F7EVS0 349
type: UnificationXref
id: F7EVS0
db: uniprot

TFIIH complex
type: Protein
entity reference: TFIIH complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa46 567
comment: SPECIES_TYPE=PROTEIN

uniprot F2Z4J4 265
type: UnificationXref
id: F2Z4J4
db: uniprot

eco ECO:0000316 235
type: UnificationXref
id: ECO:0000316
db: eco

uniprot Q9BIB4 372
type: UnificationXref
id: Q9BIB4
db: uniprot

elongating mRNA s46 a123 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: elongating mRNA
stoichiometric coefficient: 1.0

TFIIA complex
type: Protein
entity reference: TFIIA complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa47 569
comment: SPECIES_TYPE=PROTEIN

General transcription factor IIE subunit 1
type: ProteinReference
xref: uniprot Q9D0D5 429
xref: PTHR13097:SF7
organism: Mus musculus

ncbitaxon 237561 118
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot Q05913 382
type: UnificationXref
id: Q05913
db: uniprot

CBP P300 s66 sa53 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.11
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

General transcription factor IIE subunit 1
type: ProteinReference
xref: uniprot E2R3P2 412
xref: PTHR13097:SF7
organism: Canis lupus familiaris

uniprot P43072 471
type: UnificationXref
id: P43072
db: uniprot

uniprot Q9LF25 206
type: UnificationXref
id: Q9LF25
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 138

uniprot A0A1D5Q9P6 342
type: UnificationXref
id: A0A1D5Q9P6
db: uniprot

DNA-directed RNA polymerases II and IV subunit 5A
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot O81098 284
organism: Arabidopsis thaliana

uniprot Q62311 185
type: UnificationXref
id: Q62311
db: uniprot

Cilia and flagella associated protein 20
type: ProteinReference
xref: uniprot F6R525 457
organism: Monodelphis domestica

Transcription factor IIIB 50 kDa subunit
type: ProteinReference
xref: uniprot Q9HAW0 499
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot H3FFR1 279
organism: Pristionchus pacificus

uniprot O74825 283
type: UnificationXref
id: O74825
db: uniprot

Os01g0510800 protein
type: ProteinReference
xref: PTHR10221:SF9
xref: uniprot Q8LRG9 199
organism: Oryza sativa

Danio rerio
type: BioSource
xref: ncbitaxon 7955 4

PARTICIPANT STOICHIOMETRY r63 728
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RGQ0 432
xref: PTHR10445:SF0
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r63 729
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

uniprot Q385V6 104
type: UnificationXref
id: Q385V6
db: uniprot

uniprot P20226 531
type: UnificationXref
id: P20226
db: uniprot

CREB
type: Protein
entity reference: CREB
feature: ACTIVE 57
feature: CREB s158 sa39 rs1

TBP-associated factors
type: Protein
entity reference: TBP-associated factors
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa26 635
comment: SPECIES_TYPE=PROTEIN

Transcription initiation factor TFIID subunit 9
type: ProteinReference
xref: uniprot Q17QQ4 174
organism: Bos taurus

uniprot B1H3B7 379
type: UnificationXref
id: B1H3B7
db: uniprot

CREB s67 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

uniprot F7CX67 275
type: UnificationXref
id: F7CX67
db: uniprot

uniprot P52654 357
type: UnificationXref
id: P52654
db: uniprot

uniprot Q15361 336
type: UnificationXref
id: Q15361
db: uniprot

uniprot Q6PBJ2 487
type: UnificationXref
id: Q6PBJ2
db: uniprot

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 99

uniprot Q5ZKX3 183
type: UnificationXref
id: Q5ZKX3
db: uniprot

AGAP006355-PA
type: ProteinReference
xref: uniprot Q5TR07 426
organism: Anopheles gambiae

uniprot Q9SVG6 431
type: UnificationXref
id: Q9SVG6
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 57
feature: PKA s107 a244 rs1
comment: SPECIES_TYPE=PROTEIN

TATA-box binding protein associated factor 2
type: ProteinReference
xref: uniprot F6UTN8 143
organism: Canis lupus familiaris

uniprot Q7QBM3 193
type: UnificationXref
id: Q7QBM3
db: uniprot

uniprot Q7PJW8 313
type: UnificationXref
id: Q7PJW8
db: uniprot

CRE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s163 a257 663
comment: SPECIES_TYPE=GENE

TAF7 RNA polymerase II, TATA box-binding protein (TBP)-associated factor
type: ProteinReference
xref: uniprot Q8JHG4 197
organism: Danio rerio

HETERODIMER_ASSOCIATION_LEFT__TBP_associated_factors-_TBP-RIGHT__Complex__TBP_TBP_associated_factors_-_r36
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 715
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 716
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 717
left: TBP-associated factors
left: TBP
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TBP/TBP-associated factors)

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: PTHR12716:SF8
xref: uniprot F1MUX7 219
organism: Bos taurus

TATA box Promoter s33 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TATA box Promoter
stoichiometric coefficient: 1.0

Meiosis I arrest, isoform A
type: ProteinReference
xref: uniprot Q9VND0 214
organism: Drosophila melanogaster

Transcription termination factor 2
type: ProteinReference
xref: uniprot Q9UNY4 341
organism: Homo sapiens

General transcription factor IIB
type: ProteinReference
xref: uniprot H2PZC5 462
organism: Pan troglodytes

uniprot Q6P0T2 189
type: UnificationXref
id: Q6P0T2
db: uniprot

TFIIA complex
type: Protein
entity reference: TFIIA complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa21 659
comment: SPECIES_TYPE=PROTEIN

uniprot Q561R7 403
type: UnificationXref
id: Q561R7
db: uniprot

Transcription factor IIIB 90 kDa subunit
type: ProteinReference
xref: uniprot Q92994 498
organism: Homo sapiens

uniprot P05987 81
type: UnificationXref
id: P05987
db: uniprot

Mitochondrial transcription termination factor 2
type: ProteinReference
xref: PTHR15437:SF1
xref: uniprot H2Q6S6 334
organism: Pan troglodytes

uniprot Q6PDZ2 191
type: UnificationXref
id: Q6PDZ2
db: uniprot

CREB
type: Protein
entity reference: CREB
feature: ACTIVE 57
feature: CREB s53 sa35 rs1

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 12

Complex TATA box Promoter RNA Polymerase II TFIIF TBP TBP associated factors TFIIH complex TFIIA complex TFIIB s91 a200 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (TATA box Promoter/RNA Polymerase II/ TFIIF/TBP/ TBP-associated factors/TFIIH complex/ TFIIA complex/TFIIB)
stoichiometric coefficient: 1.0

TBP associated factors s13 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP-associated factors
stoichiometric coefficient: 1.0

uniprot P10644 85
type: UnificationXref
id: P10644
db: uniprot

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: uniprot Q80ZM7 368
organism: Mus musculus

uniprot Q15544 169
type: UnificationXref
id: Q15544
db: uniprot

Transcription initiation factor TFIID subunit 2
type: ProteinReference
xref: uniprot P87121 168
organism: Schizosaccharomyces pombe

uniprot E2R5J2 218
type: UnificationXref
id: E2R5J2
db: uniprot

Transcription initiation factor TFIID subunit 6
type: ProteinReference
xref: uniprot P53040 167
organism: Saccharomyces cerevisiae

TATA-box-binding protein-associated factor 2
type: ProteinReference
xref: uniprot F1LNY6 135
organism: Rattus norvegicus

uniprot Q8LRG9 199
type: UnificationXref
id: Q8LRG9
db: uniprot

uniprot P49605 98
type: UnificationXref
id: P49605
db: uniprot

TBP associated factors s19 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP-associated factors
stoichiometric coefficient: 1.0

TATA-box-binding protein
type: ProteinReference
xref: uniprot Q7SXL3 550
xref: PTHR10126:SF42
organism: Danio rerio

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: PTHR12716:SF8
xref: uniprot F7CP70 414
organism: Monodelphis domestica

Cilia and flagella associated protein 20
type: ProteinReference
xref: uniprot E2R3J4 449
organism: Canis lupus familiaris

HETERODIMER_ASSOCIATION_LEFT__TFIIFbeta-_TFIIFalpha-RIGHT__TFIIF-_r32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 726
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 725
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 727
left: TFIIFbeta
left: TFIIFalpha
interaction type: HETERODIMER_ASSOCIATION
right: TFIIF

CREB s164 sa37 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

Complex CBP P300 CREB s152 a289 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (CBP/P300/ CREB)
stoichiometric coefficient: 1.0

uniprot Q28HF5 304
type: UnificationXref
id: Q28HF5
db: uniprot

uniprot F6UPU0 142
type: UnificationXref
id: F6UPU0
db: uniprot

uniprot Q9D2A5 54
type: UnificationXref
id: Q9D2A5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2QVZ3 130
organism: Canis lupus familiaris

uniprot Q7SG05 367
type: UnificationXref
id: Q7SG05
db: uniprot

uniprot Q99PM3 371
type: UnificationXref
id: Q99PM3
db: uniprot

TFIIB s27 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIB
stoichiometric coefficient: 1.0

uniprot H2R9Q1 155
type: UnificationXref
id: H2R9Q1
db: uniprot

s169
type: Complex
component stoichiometry: Complex TATA box Promoter RNA Polymerase II TFIIF TBP TBP associated factors TFIIH complex TFIIA complex TFIIB s91 a200 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex CBP P300 CREB s152 a289 STOICHIOMETRY ID COMPLEX
component: Complex (TATA box Promoter/RNA Polymerase II/ TFIIF/TBP/ TBP-associated factors/TFIIH complex/ TFIIA complex/TFIIB)
component: Complex (CBP/P300/ CREB)
feature: COMPLEX BINDING FEATURE s169 csa26 608
feature: COMPLEX BINDING FEATURE s169 csa26 606

TATA box Promoter gene termination
type: DnaRegion
comment: SPECIES_TYPE=GENE

Cyclic AMP-responsive element-binding protein 3-like protein 1
type: ProteinReference
xref: uniprot G7NDH4 22
xref: PTHR46004:SF1
organism: Macaca mulatta

uniprot Q4V8D6 481
type: UnificationXref
id: Q4V8D6
db: uniprot

TFIIB s65 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIB
stoichiometric coefficient: 1.0

uniprot P19388 290
type: UnificationXref
id: P19388
db: uniprot

General transcription factor IIF subunit 1
type: ProteinReference
xref: PTHR13011:SF0
xref: uniprot P35269 381
organism: Homo sapiens

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot P52434 293
organism: Homo sapiens

TATA-box-binding protein 2
type: ProteinReference
xref: PTHR10126:SF54
xref: uniprot P28148 534
organism: Arabidopsis thaliana

RNA Polymerase II
type: Protein
entity reference: RNA Polymerase II
feature: RNA Polymerase II s57 sa42 rs2
feature: ACTIVE 57
feature: RNA Polymerase II s57 sa42 rs3
feature: RNA Polymerase II s57 sa42 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa42 559
feature: RNA Polymerase II s57 sa42 rs1
comment: SPECIES_TYPE=PROTEIN

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: uniprot E2R3G8 346
organism: Canis lupus familiaris

uniprot C3ZB94 448
type: UnificationXref
id: C3ZB94
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VEJ6 523
xref: PTHR10126:SF37
organism: Macaca mulatta

CBP P300 s104 a238 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.11
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

General transcription factor IIH subunit 3
type: ProteinReference
xref: uniprot Q8VD76 406
organism: Mus musculus

STATE_TRANSITION_LEFT__ATP-_CREB-RIGHT__ADP-_CREB-_r63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 731
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 729
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 728
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 730
left: ATP
left: CREB
interaction type: STATE_TRANSITION
right: CREB
right: ADP

cAMP-dependent protein kinase type I regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P16905 91
organism: Drosophila melanogaster

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot A7MAZ4 125
organism: Bos taurus

CREB3L1 isoform 1
type: ProteinReference
xref: uniprot H2Q3H4 26
xref: PTHR46004:SF1
organism: Pan troglodytes

General transcription factor IIB
type: ProteinReference
xref: uniprot A0A0R4IRB5 443
organism: Danio rerio

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot F7GF94 276
organism: Monodelphis domestica

GTF2H3 isoform 1
type: ProteinReference
xref: uniprot K7D0H2 392
organism: Pan troglodytes

Transcription initiation factor IIF subunit beta
type: ProteinReference
xref: uniprot P41896 438
organism: Saccharomyces cerevisiae

uniprot Q5I0F6 108
type: UnificationXref
id: Q5I0F6
db: uniprot

uniprot P87303 396
type: UnificationXref
id: P87303
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_CREB-RIGHT__ADP-_CREB-_r63
controller: PKA

uniprot A0A3Q2TVW3 242
type: UnificationXref
id: A0A3Q2TVW3
db: uniprot

Cilia- and flagella-associated protein 20
type: ProteinReference
xref: uniprot Q6PBJ2 487
organism: Danio rerio

DNA-directed RNA polymerases I, II, and III subunit RPABC1
type: ProteinReference
xref: uniprot B0BNE2 246
organism: Rattus norvegicus

CRE s70 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRE
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BEL5 518
organism: Bos taurus

TATA-box binding protein associated factor 6
type: ProteinReference
xref: uniprot E2RFB9 132
organism: Canis lupus familiaris

uniprot Q5EA53 384
type: UnificationXref
id: Q5EA53
db: uniprot

HOMODIMER ID 59STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MAS3 261
organism: Rattus norvegicus

Transcription termination factor 1b, mitochondrial
type: ProteinReference
xref: uniprot B9EJ57 332
organism: Mus musculus

uniprot Q12004 399
type: UnificationXref
id: Q12004
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BXN9 272
organism: Monodelphis domestica

uniprot P23255 161
type: UnificationXref
id: P23255
db: uniprot

DNA-directed RNA polymerases I, II, and III subunit RPABC1
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot Q09191 298
organism: Schizosaccharomyces pombe

uniprot Q2HJG8 178
type: UnificationXref
id: Q2HJG8
db: uniprot

uniprot O13749 467
type: UnificationXref
id: O13749
db: uniprot

ncbitaxon 7227 35
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot Q7Q1Q4 488
type: UnificationXref
id: Q7Q1Q4
db: uniprot

uniprot P62876 297
type: UnificationXref
id: P62876
db: uniprot

Cyclic AMP-responsive element-binding protein 3
type: ProteinReference
xref: uniprot Q61817 42
xref: PTHR45996:SF4
organism: Mus musculus

CRE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s166 a259 623
comment: SPECIES_TYPE=GENE

uniprot P87121 168
type: UnificationXref
id: P87121
db: uniprot

uniprot Q32L01 361
type: UnificationXref
id: Q32L01
db: uniprot

uniprot P20227 532
type: UnificationXref
id: P20227
db: uniprot

ncbitaxon 9913 9
type: UnificationXref
id: 9913
db: ncbitaxon

General transcription factor IIF subunit 2
type: ProteinReference
xref: PTHR10445:SF0
xref: uniprot F6QZ41 433
organism: Monodelphis domestica

uniprot Q24320 302
type: UnificationXref
id: Q24320
db: uniprot

PARTICIPANT STOICHIOMETRY r83 713
type: Stoichiometry
physical entity: hormone
stoichiometric coefficient: 1.0

uniprot Q9VWW0 55
type: UnificationXref
id: Q9VWW0
db: uniprot

PARTICIPANT STOICHIOMETRY r83 714
type: Stoichiometry
physical entity: Complex (Receptor/hormone)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r83 712
type: Stoichiometry
physical entity: Receptor
stoichiometric coefficient: 1.0

uniprot Q8VD76 406
type: UnificationXref
id: Q8VD76
db: uniprot

Transcription initiation factor TFIID subunit 6
type: ProteinReference
xref: uniprot P49848 164
organism: Homo sapiens

uniprot Q2T9L9 441
type: UnificationXref
id: Q2T9L9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F4NX01 454
organism: Batrachochytrium dendrobatidis

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EVS0 349
xref: PTHR12694:SF7
organism: Monodelphis domestica

uniprot F6T7D0 230
type: UnificationXref
id: F6T7D0
db: uniprot

uniprot A0A0R4IRB5 443
type: UnificationXref
id: A0A0R4IRB5
db: uniprot

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot G3V678 277
organism: Rattus norvegicus

Transcription initiation factor TFIID subunit 6
type: ProteinReference
xref: uniprot P49847 163
organism: Drosophila melanogaster

uniprot P12369 88
type: UnificationXref
id: P12369
db: uniprot

Thermococcus kodakaraensis
type: BioSource
xref: ncbitaxon 69014 474

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
type: ProteinReference
xref: uniprot Q3ZBP7 180
organism: Bos taurus

CREB s103 a237 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot Q5KNS1 109
organism: Cryptococcus neoformans

TATA box-binding protein-like protein 2
type: ProteinReference
xref: uniprot Q6SJ95 546
xref: PTHR10126:SF37
organism: Mus musculus

uniprot A0A0R4IB23 3
type: UnificationXref
id: A0A0R4IB23
db: uniprot

TATA box-binding protein-like protein 2
type: ProteinReference
xref: PTHR10126:SF37
xref: uniprot Q6SJ96 547
organism: Homo sapiens

uniprot Q8JHG4 197
type: UnificationXref
id: Q8JHG4
db: uniprot

uniprot Q9UNY4 341
type: UnificationXref
id: Q9UNY4
db: uniprot

AGAP005731-PA (Fragment)
type: ProteinReference
xref: uniprot A7UTV1 126
organism: Anopheles gambiae

ncbitaxon 7955 4
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot O74948 354
type: UnificationXref
id: O74948
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot P10644 85
organism: Homo sapiens

uniprot Q503H9 362
type: UnificationXref
id: Q503H9
db: uniprot

General transcription factor IIE subunit 1
type: ProteinReference
xref: uniprot F7GV34 415
xref: PTHR13097:SF7
organism: Macaca mulatta

uniprot Q8TEY5 51
type: UnificationXref
id: Q8TEY5
db: uniprot

uniprot D3ZCP9 411
type: UnificationXref
id: D3ZCP9
db: uniprot

uniprot F7GV34 415
type: UnificationXref
id: F7GV34
db: uniprot

uniprot P29083 421
type: UnificationXref
id: P29083
db: uniprot

Transcription factor TFIIH subunit Tfb4
type: ProteinReference
xref: uniprot Q1K4W6 401
organism: Neurospora crassa

TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1
type: ProteinReference
xref: uniprot F6UPU0 142
xref: PTHR15319:SF1
organism: Macaca mulatta

uniprot G3V992 416
type: UnificationXref
id: G3V992
db: uniprot

uniprot O08949 352
type: UnificationXref
id: O08949
db: uniprot

Transcription initiation factor TFIID subunit 6
type: ProteinReference
xref: PTHR10221:SF13
xref: uniprot Q9MAU3 207
organism: Arabidopsis thaliana

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: uniprot H2QZJ1 419
xref: PTHR12716:SF8
organism: Pan troglodytes

uniprot F6VEJ6 523
type: UnificationXref
id: F6VEJ6
db: uniprot

DNA-directed RNA polymerases I, II, and III subunit RPABC1
type: ProteinReference
xref: uniprot Q80UW8 320
organism: Mus musculus

uniprot H2QZJ1 419
type: UnificationXref
id: H2QZJ1
db: uniprot

TFIIA complex s32 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIA complex
stoichiometric coefficient: 1.0

uniprot P49847 163
type: UnificationXref
id: P49847
db: uniprot

CREB3L2 protein
type: ProteinReference
xref: uniprot A7YY66 10
xref: PTHR46004:SF2
organism: Bos taurus

uniprot F6YKC3 524
type: UnificationXref
id: F6YKC3
db: uniprot

General transcription factor 2A subunit 1-like
type: ProteinReference
xref: PTHR12694:SF9
xref: uniprot Q641W8 363
organism: Rattus norvegicus

uniprot F1PQA5 520
type: UnificationXref
id: F1PQA5
db: uniprot

uniprot P52655 358
type: UnificationXref
id: P52655
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NHV9 262
organism: Gallus gallus

TATA box Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa19 655
comment: SPECIES_TYPE=GENE

uniprot F7F0D8 391
type: UnificationXref
id: F7F0D8
db: uniprot

Transcription initiation factor TFIID subunit 7-like
type: ProteinReference
xref: uniprot Q9D3R9 203
organism: Mus musculus

General transcription factor IIH subunit 3
type: ProteinReference
xref: uniprot Q86IB5 405
organism: Dictyostelium discoideum

CREB s67 sa54 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

uniprot F4IW19 453
type: UnificationXref
id: F4IW19
db: uniprot

ncbitaxon 64091 501
type: UnificationXref
id: 64091
db: ncbitaxon

Bromodomain transcription factor
type: ProteinReference
xref: uniprot Q9LF25 206
xref: PTHR46338:SF10
organism: Arabidopsis thaliana

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: ProteinReference
xref: uniprot Q08C49 103
xref: PTHR11635:SF126
organism: Danio rerio

TATA box Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s71 sa56 585
comment: SPECIES_TYPE=GENE

DNA-directed RNA polymerases I, II, and III subunit RPABC2
type: ProteinReference
xref: uniprot P61219 295
xref: PTHR10773:SF12
organism: Mus musculus

Transcription initiation factor TFIID subunit 9
type: ProteinReference
xref: uniprot Q5BKE0 181
organism: Rattus norvegicus

TBP
type: Protein
entity reference: TBP
comment: SPECIES_TYPE=PROTEIN

PTHR10221:SF9
type: RelationshipXref
id: PTHR10221:SF9
db: PANTHER Family
relationship type: By Homology

DNA-directed RNA polymerases I, II, and III subunit RPABC2
type: ProteinReference
xref: PTHR10773:SF12
xref: uniprot P61218 294
organism: Homo sapiens

uniprot A7MAZ4 125
type: UnificationXref
id: A7MAZ4
db: uniprot

Transcription initiation factor TFIID subunit 9B
type: ProteinReference
xref: uniprot Q62880 186
organism: Rattus norvegicus

Transcription factor IIIB 70 kDa subunit
type: ProteinReference
xref: uniprot P43072 471
organism: Candida albicans

CBP/P300
type: Protein
entity reference: CBP/P300
feature: ACTIVE 57
feature: CBP P300 s66 sa53 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa53 573
comment: SPECIES_TYPE=PROTEIN

CREB s164 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

uniprot P16370 288
type: UnificationXref
id: P16370
db: uniprot

cAMP-responsive element-binding protein 1b
type: ProteinReference
xref: uniprot A0A0R4IFU8 7
organism: Danio rerio

uniprot F6R7N8 71
type: UnificationXref
id: F6R7N8
db: uniprot

TFIIFalpha
type: ProteinReference
xref: P01391
standard name: General transcription factor IIF, polypeptide 1, 74-KD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TFIIF_alpha_
comment: ENTITY_REFERENCE_NOTES= Long Name: General transcription factor IIF, polypeptide 1, 74-KD Synonym: BTF4,GTF2F1,RAP74,TF2F1,TFIIF ALPHA,TRANSCRIPTION FACTOR IIF Accession: P01391
member entity reference: General transcription factor IIF subunit 1
member entity reference: GTF2F1 isoform 2

DNA binding / DNA-directed RNA polymerase
type: ProteinReference
xref: uniprot F4J2R9 266
organism: Arabidopsis thaliana

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 268

Uncharacterized protein
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot E7FDD7 257
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot F6S0M5 139
organism: Monodelphis domestica

TFIIB
type: Protein
entity reference: TFIIB
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa48 571
comment: SPECIES_TYPE=PROTEIN

PTHR12694:SF15
type: RelationshipXref
id: PTHR12694:SF15
db: PANTHER Family
relationship type: By Homology

uniprot B0BNE2 246
type: UnificationXref
id: B0BNE2
db: uniprot

PTHR10966:SF5
type: RelationshipXref
id: PTHR10966:SF5
db: PANTHER Family
relationship type: By Homology

TATA-box binding protein associated factor 9
type: ProteinReference
xref: uniprot E2R911 131
organism: Canis lupus familiaris

General transcription factor IIF subunit 2
type: ProteinReference
xref: uniprot H2R032 434
organism: Pan troglodytes

Predicted protein
type: ProteinReference
xref: uniprot A7SLP4 244
organism: Nematostella vectensis

PARTICIPANT STOICHIOMETRY r59 748
type: Stoichiometry
physical entity: TFIIB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 747
type: Stoichiometry
physical entity: TFIIA complex
stoichiometric coefficient: 1.0

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR10966:SF2
type: RelationshipXref
id: PTHR10966:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10966:SF0
type: RelationshipXref
id: PTHR10966:SF0
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r59 744
type: Stoichiometry
physical entity: s169
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 745
type: Stoichiometry
physical entity: TFIIH complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 746
type: Stoichiometry
physical entity: s170
stoichiometric coefficient: 1.0

uniprot P19387 289
type: UnificationXref
id: P19387
db: uniprot

uniprot Q86IB5 405
type: UnificationXref
id: Q86IB5
db: uniprot

CBP P300 s54 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CBP/P300
stoichiometric coefficient: 1.0

uniprot Q19826 299
type: UnificationXref
id: Q19826
db: uniprot

TTF2
type: Protein
entity reference: TTF2
feature: COMPLEX PARTICIPANT BINDING FEATURE s184 a293 601
comment: SPECIES_TYPE=PROTEIN

Transcription initiation factor TFIID subunit 2
type: ProteinReference
xref: uniprot Q6P1X5 190
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__Complex__CBP_P300__CREB_-_Complex__TBP_TBP_associated_factors_-_TFIIA_complex-_Complex__CRE_TATA_box_Promoter_-RIGHT__s160-_r86
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 764
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 763
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 761
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 765
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 762
left: TFIIA complex
left: Complex (CRE/TATA box Promoter)
left: Complex (CBP/P300/ CREB)
left: Complex (TBP/TBP-associated factors)
interaction type: HETERODIMER_ASSOCIATION
right: s160

uniprot Q05B56 398
type: UnificationXref
id: Q05B56
db: uniprot

TATA-box-binding protein 2
type: ProteinReference
xref: uniprot C4M7H7 515
xref: PTHR10126:SF42
organism: Entamoeba histolytica

TBP s179 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 14

General transcription and DNA repair factor IIH subunit TFB4
type: ProteinReference
xref: uniprot Q12004 399
organism: Saccharomyces cerevisiae

uniprot G7NFD1 23
type: UnificationXref
id: G7NFD1
db: uniprot

uniprot E1B8D6 226
type: UnificationXref
id: E1B8D6
db: uniprot

CREB3L3 isoform 2
type: ProteinReference
xref: uniprot H2QF07 27
xref: PTHR45996:SF1
organism: Pan troglodytes

uniprot Q08C49 103
type: UnificationXref
id: Q08C49
db: uniprot

uniprot Q9NEW8 208
type: UnificationXref
id: Q9NEW8
db: uniprot

uniprot Q7QA87 365
type: UnificationXref
id: Q7QA87
db: uniprot

uniprot Q9P6R0 505
type: UnificationXref
id: Q9P6R0
db: uniprot

PTHR12694:SF9
type: RelationshipXref
id: PTHR12694:SF9
db: PANTHER Family
relationship type: By Homology

ncbitaxon 13616 16
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot E2R3G8 346
type: UnificationXref
id: E2R3G8
db: uniprot

PTHR12694:SF8
type: RelationshipXref
id: PTHR12694:SF8
db: PANTHER Family
relationship type: By Homology

TFIIB
type: Protein
entity reference: TFIIB
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa20 657
comment: SPECIES_TYPE=PROTEIN

PTHR12694:SF7
type: RelationshipXref
id: PTHR12694:SF7
db: PANTHER Family
relationship type: By Homology

General transcription and DNA repair factor IIH subunit TFB2
type: ProteinReference
xref: uniprot Q02939 397
organism: Saccharomyces cerevisiae

uniprot A0A1D5QA17 121
type: UnificationXref
id: A0A1D5QA17
db: uniprot

RNA s47 a128 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA
stoichiometric coefficient: 1.0

uniprot H2Q3H4 26
type: UnificationXref
id: H2Q3H4
db: uniprot

ATF (cAMP-dependent transcription factor) family
type: ProteinReference
xref: uniprot Q20435 38
organism: Caenorhabditis elegans

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot Q92399 322
organism: Schizosaccharomyces pombe

uniprot P32085 535
type: UnificationXref
id: P32085
db: uniprot

Complex (TBP/TBP-associated factors)
type: Complex
component stoichiometry: TBP associated factors s178 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBP s179 sa7 STOICHIOMETRY ID COMPLEX
component: TBP-associated factors
component: TBP
feature: COMPLEX BINDING FEATURE s177 a125 614
feature: COMPLEX PARTICIPANT BINDING FEATURE s177 a125 695
feature: COMPLEX BINDING FEATURE s177 a125 616

uniprot H2RD22 527
type: UnificationXref
id: H2RD22
db: uniprot

uniprot F4J2R9 266
type: UnificationXref
id: F4J2R9
db: uniprot

PKA s107 a244 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=0.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q3THK3 383
type: UnificationXref
id: Q3THK3
db: uniprot

uniprot Q7Z7C8 195
type: UnificationXref
id: Q7Z7C8
db: uniprot

POLR2C isoform 1
type: ProteinReference
xref: uniprot H2QB71 278
xref: PTHR11800:SF2
organism: Pan troglodytes

uniprot Q1K5K1 301
type: UnificationXref
id: Q1K5K1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BSY6 253
organism: Gallus gallus

uniprot Q9VHY5 213
type: UnificationXref
id: Q9VHY5
db: uniprot

General transcription factor IIE subunit 2
type: ProteinReference
xref: uniprot Q9D902 224
xref: PTHR12716:SF8
organism: Mus musculus

uniprot F7H5J8 350
type: UnificationXref
id: F7H5J8
db: uniprot

ncbitaxon 6238 513
type: UnificationXref
id: 6238
db: ncbitaxon

At3g02160
type: ProteinReference
xref: PTHR46338:SF7
xref: uniprot Q9S7R9 210
organism: Arabidopsis thaliana

uniprot P62380 538
type: UnificationXref
id: P62380
db: uniprot

uniprot Q1ECU1 300
type: UnificationXref
id: Q1ECU1
db: uniprot

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot P81900 100
organism: Drosophila melanogaster

CREB
type: Protein
entity reference: CREB
feature: ACTIVE 57
feature: CREB s102 a227 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot C4M7H7 515
type: UnificationXref
id: C4M7H7
db: uniprot

uniprot E2RRA1 66
type: UnificationXref
id: E2RRA1
db: uniprot

AGAP009680-PA
type: ProteinReference
xref: uniprot Q7Q1Q4 488
organism: Anopheles gambiae

uniprot F7HU28 461
type: UnificationXref
id: F7HU28
db: uniprot

TBP s14 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

Cyclic AMP-responsive element-binding protein 5
type: ProteinReference
xref: uniprot Q02930 36
organism: Homo sapiens

uniprot P49906 166
type: UnificationXref
id: P49906
db: uniprot

uniprot Q9HEW1 117
type: UnificationXref
id: Q9HEW1
db: uniprot

uniprot E2R911 131
type: UnificationXref
id: E2R911
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q9S4 70
organism: Bos taurus

GTF2F1 isoform 2
type: ProteinReference
xref: PTHR13011:SF0
xref: uniprot H2QF47 380
organism: Pan troglodytes

uniprot Q80UW8 320
type: UnificationXref
id: Q80UW8
db: uniprot

General transcription and DNA repair factor IIH subunit tcf-29
type: ProteinReference
xref: uniprot Q9P5N7 409
organism: Neurospora crassa

uniprot P12368 87
type: UnificationXref
id: P12368
db: uniprot

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 501

uniprot P58109 473
type: UnificationXref
id: P58109
db: uniprot

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot Q8W0W3 495
organism: Oryza sativa

uniprot Q7RVB4 549
type: UnificationXref
id: Q7RVB4
db: uniprot

TBP-Like Factor
type: ProteinReference
xref: uniprot B2D6P4 514
xref: PTHR10126:SF55
organism: Caenorhabditis elegans

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 115

uniprot Q8R4I4 369
type: UnificationXref
id: Q8R4I4
db: uniprot

TBP
type: Protein
entity reference: TBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa1 611
comment: SPECIES_TYPE=PROTEIN

cAMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Transcription termination factor 1a, mitochondrial
type: ProteinReference
xref: uniprot Q8CHZ9 340
organism: Mus musculus

TATA-box-binding protein-associated factor 6
type: ProteinReference
xref: uniprot F6STP6 141
organism: Xenopus tropicalis

PTHR10221:SF13
type: RelationshipXref
id: PTHR10221:SF13
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__TFIIF-_RNA_Polymerase_II-RIGHT__Complex__TFIIF_RNA_Polymerase_II_-_r55
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 766
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 767
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 768
left: RNA Polymerase II
left: TFIIF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TFIIF/RNA Polymerase II)

ncbitaxon 44689 82
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot Q8TTZ7 552
type: UnificationXref
id: Q8TTZ7
db: uniprot

TATA-binding protein
type: ProteinReference
xref: uniprot Q7RVB4 549
xref: PTHR10126:SF42
organism: Neurospora crassa

TBP
type: Protein
entity reference: TBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s186 sa9 589
comment: SPECIES_TYPE=PROTEIN

TBP associated factors s39 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP-associated factors
stoichiometric coefficient: 1.0

RNA Polymerase II
type: Protein
entity reference: RNA Polymerase II
feature: ACTIVE 57
feature: RNA Polymerase II s26 a132 rs2
feature: RNA Polymerase II s26 a132 rs1
feature: RNA Polymerase II s26 a132 rs4
feature: RNA Polymerase II s26 a132 rs3
comment: SPECIES_TYPE=PROTEIN

s181
type: Complex
component stoichiometry: TTF2 s184 a293 STOICHIOMETRY ID COMPLEX
component stoichiometry: RNA Polymerase II s183 a127 STOICHIOMETRY ID COMPLEX
component stoichiometry: RNA s47 a128 STOICHIOMETRY ID COMPLEX
component stoichiometry: TATA box Promoter gene termination s182 a126 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex TBP TBP associated factors s185 a129 STOICHIOMETRY ID COMPLEX
component: RNA
component: Complex (TBP/TBP-associated factors)
component: TATA box Promoter gene termination
component: TTF2
component: RNA Polymerase II
feature: COMPLEX BINDING FEATURE s181 csa29 598
feature: COMPLEX BINDING FEATURE s181 csa29 596
feature: COMPLEX BINDING FEATURE s181 csa29 600
feature: COMPLEX BINDING FEATURE s181 csa29 594
feature: COMPLEX BINDING FEATURE s181 csa29 592

DNA-directed RNA polymerase II subunit rpb4
type: ProteinReference
xref: uniprot O74825 283
organism: Schizosaccharomyces pombe

uniprot Q9R1C0 209
type: UnificationXref
id: Q9R1C0
db: uniprot

TATA-box binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot H2RD22 527
organism: Pan troglodytes

uniprot H2QB82 464
type: UnificationXref
id: H2QB82
db: uniprot

CFAP20 isoform 1
type: ProteinReference
xref: uniprot H2QB82 464
organism: Pan troglodytes

uniprot Q568H8 308
type: UnificationXref
id: Q568H8
db: uniprot

TFIIE
type: Protein
entity reference: TFIIE
comment: SPECIES_TYPE=PROTEIN

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot P12367 86
type: UnificationXref
id: P12367
db: uniprot

TTF2
type: Protein
entity reference: TTF2
comment: SPECIES_TYPE=PROTEIN

TBP-associated factors
type: Protein
entity reference: TBP-associated factors
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa45 565
comment: SPECIES_TYPE=PROTEIN

Cilia- and flagella-associated protein 20
type: ProteinReference
xref: uniprot Q6B857 486
organism: Bos taurus

uniprot P07278 83
type: UnificationXref
id: P07278
db: uniprot

CBP/P300
type: Protein
entity reference: CBP/P300
feature: ACTIVE 57
feature: CBP P300 s104 a238 rs1
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__UTP-_s170-_ATP-_GTP-_CTP-RIGHT__s173-_r60
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 740
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 738
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 737
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 736
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 735
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 739
left: CTP
left: GTP
left: UTP
left: ATP
left: s170
interaction type: STATE_TRANSITION
right: s173

uniprot Q09472 236
type: UnificationXref
id: Q09472
db: uniprot

TBP associated factors s187 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP-associated factors
stoichiometric coefficient: 1.0

uniprot O13270 528
type: UnificationXref
id: O13270
db: uniprot

s173
type: Complex
component stoichiometry: Complex TBP TBP associated factors s177 a125 STOICHIOMETRY ID COMPLEX
component stoichiometry: elongating mRNA s46 a123 STOICHIOMETRY ID COMPLEX
component stoichiometry: RNA Polymerase II s180 a122 STOICHIOMETRY ID COMPLEX
component stoichiometry: TATA box Promoter gene s28 a121 STOICHIOMETRY ID COMPLEX
component: elongating mRNA
component: RNA Polymerase II
component: TATA box Promoter gene
component: Complex (TBP/TBP-associated factors)
feature: COMPLEX BINDING FEATURE s173 csa28 694
feature: COMPLEX BINDING FEATURE s173 csa28 696
feature: COMPLEX BINDING FEATURE s173 csa28 698
feature: COMPLEX BINDING FEATURE s173 csa28 700

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot Q6JHU9 237
organism: Rattus norvegicus

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

uniprot F7E5W7 145
type: UnificationXref
id: F7E5W7
db: uniprot

uniprot G3V678 277
type: UnificationXref
id: G3V678
db: uniprot

Cyclic AMP-responsive element-binding protein 3-like protein 3
type: ProteinReference
xref: uniprot Q68CJ9 44
xref: PTHR45996:SF1
organism: Homo sapiens

Cyclin/Brf1-like TBP-binding protein
type: ProteinReference
xref: uniprot F4IW19 453
organism: Arabidopsis thaliana

RNA Polymerase II
type: Protein
entity reference: RNA Polymerase II
feature: RNA Polymerase II s16 a29 rs1
feature: RNA Polymerase II s16 a29 rs4
feature: RNA Polymerase II s16 a29 rs3
feature: RNA Polymerase II s16 a29 rs2
comment: SPECIES_TYPE=PROTEIN

uniprot P45481 234
type: UnificationXref
id: P45481
db: uniprot

uniprot H2QLS0 232
type: UnificationXref
id: H2QLS0
db: uniprot

uniprot K7AEL3 76
type: UnificationXref
id: K7AEL3
db: uniprot

Receptor
type: Protein
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa51 619
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

AGAP010321-PA
type: ProteinReference
xref: uniprot Q7Q2H6 316
xref: PTHR11800:SF2
organism: Anopheles gambiae

uniprot Q9M1J2 326
type: UnificationXref
id: Q9M1J2
db: uniprot

Cyclic AMP-responsive element-binding protein 5
type: ProteinReference
xref: uniprot Q8K1L0 48
organism: Mus musculus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 37

Cyclic AMP-responsive element-binding protein 3
type: ProteinReference
xref: uniprot Q8SQ19 49
xref: PTHR45996:SF4
organism: Bos taurus

DNA-directed RNA polymerase II polypeptide
type: ProteinReference
xref: PTHR11800:SF2
xref: uniprot Q1K5K1 301
organism: Neurospora crassa

ncbitaxon 7668 120
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot E2RPD9 255
type: UnificationXref
id: E2RPD9
db: uniprot

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

uniprot Q6SJ95 546
type: UnificationXref
id: Q6SJ95
db: uniprot

PTHR11635:SF152
type: RelationshipXref
id: PTHR11635:SF152
db: PANTHER Family
relationship type: By Homology

CREB s53 sa35 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

uniprot E9G2Q6 260
type: UnificationXref
id: E9G2Q6
db: uniprot

TBP s186 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

uniprot Q8CHZ9 340
type: UnificationXref
id: Q8CHZ9
db: uniprot

uniprot Q2KJ73 402
type: UnificationXref
id: Q2KJ73
db: uniprot

TATA box Promoter gene s172 a218 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TATA box Promoter gene
stoichiometric coefficient: 1.0

Complex (TATA box Promoter/RNA Polymerase II/ TFIIF/TBP/ TBP-associated factors/TFIIH complex/ TFIIA complex/TFIIB)
type: Complex
component stoichiometry: TFIIF s58 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: RNA Polymerase II s57 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIA complex s64 sa47 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIB s65 sa48 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIH complex s63 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: TATA box Promoter s56 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBP s61 sa44 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBP associated factors s62 sa45 STOICHIOMETRY ID COMPLEX
component: TBP
component: TBP-associated factors
component: TFIIB
component: TFIIH complex
component: RNA Polymerase II
component: TFIIF
component: TATA box Promoter
component: TFIIA complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 a200 607
feature: COMPLEX BINDING FEATURE s91 a200 562
feature: COMPLEX BINDING FEATURE s91 a200 556
feature: COMPLEX BINDING FEATURE s91 a200 566
feature: COMPLEX BINDING FEATURE s91 a200 564
feature: COMPLEX BINDING FEATURE s91 a200 558
feature: COMPLEX BINDING FEATURE s91 a200 568
feature: COMPLEX BINDING FEATURE s91 a200 570
feature: COMPLEX BINDING FEATURE s91 a200 560

uniprot F6Q503 69
type: UnificationXref
id: F6Q503
db: uniprot

TATA-box binding protein associated factor 11
type: ProteinReference
xref: uniprot E2RFN3 133
organism: Canis lupus familiaris

uniprot P62916 476
type: UnificationXref
id: P62916
db: uniprot

ncbitaxon 5759 516
type: UnificationXref
id: 5759
db: ncbitaxon

uniprot F6YR60 413
type: UnificationXref
id: F6YR60
db: uniprot

General transcription factor 2B
type: ProteinReference
xref: uniprot L7N3H9 466
organism: Xenopus tropicalis

uniprot Q8TI26 551
type: UnificationXref
id: Q8TI26
db: uniprot

Transcription initiation factor TFIID subunit 6
type: ProteinReference
xref: uniprot Q62311 185
organism: Mus musculus

PRKAR2A isoform 1
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot K7AEL3 76
organism: Pan troglodytes

TFIIH complex
type: Protein
entity reference: TFIIH complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa28 639
comment: SPECIES_TYPE=PROTEIN

General transcription factor IIH subunit 3
type: ProteinReference
xref: uniprot Q561R7 403
organism: Rattus norvegicus

Cyclic AMP-responsive element-binding protein 3-like protein 2
type: ProteinReference
xref: uniprot Q8BH52 47
xref: PTHR46004:SF2
organism: Mus musculus

uniprot Q66HB1 544
type: UnificationXref
id: Q66HB1
db: uniprot

uniprot Q8BH52 47
type: UnificationXref
id: Q8BH52
db: uniprot

uniprot P30625 92
type: UnificationXref
id: P30625
db: uniprot

uniprot P29055 469
type: UnificationXref
id: P29055
db: uniprot

uniprot Q13889 400
type: UnificationXref
id: Q13889
db: uniprot

uniprot Q5JGN1 484
type: UnificationXref
id: Q5JGN1
db: uniprot

TFIIE
type: ProteinReference
xref: P01395
standard name: Transcription factor IIE
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TFIIE
comment: ENTITY_REFERENCE_NOTES= Long Name: TFIIE Synonym: TF2E,TFIIE Accession: P01395
member entity reference: General transcription factor IIE subunit 1
member entity reference: TFIIE-alpha 1
member entity reference: Transcription initiation factor IIE subunit beta
member entity reference: General transcription factor IIE, polypeptide 1, alpha
member entity reference: General Transcription Factor homolog
member entity reference: Transcription initiation factor IIE (TFIIE) alpha subunit family protein / general transcription factor TFIIE family protein
member entity reference: AGAP006355-PA
member entity reference: General transcription factor IIE subunit 2
member entity reference: General transcription factor II E, polypeptide 1 (Alpha subunit)
member entity reference: Uncharacterized protein
member entity reference: Transcription initiation factor IIE subunit alpha
member entity reference: GH11150p
member entity reference: Transcription factor TFIIE complex alpha subunit
member entity reference: GTF2E1 isoform 2

uniprot Q28GI6 303
type: UnificationXref
id: Q28GI6
db: uniprot

uniprot Q70SY1 46
type: UnificationXref
id: Q70SY1
db: uniprot

Transcription initiation factor IIA small chain homolog
type: ProteinReference
xref: uniprot Q9BIB4 372
xref: PTHR10966:SF2
organism: Caenorhabditis elegans

CREB s101 a224 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot Q923G2 323
organism: Mus musculus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

RNA Polymerase II s8 sa23 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

CTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR11635:SF129
type: RelationshipXref
id: PTHR11635:SF129
db: PANTHER Family
relationship type: By Homology

uniprot A6H7G8 387
type: UnificationXref
id: A6H7G8
db: uniprot

PTHR11635:SF126
type: RelationshipXref
id: PTHR11635:SF126
db: PANTHER Family
relationship type: By Homology

cAMP responsive element binding protein 1
type: ProteinReference
xref: PTHR45879:SF1
xref: uniprot F7FD05 21
organism: Monodelphis domestica

PTHR15437:SF1
type: RelationshipXref
id: PTHR15437:SF1
db: PANTHER Family
relationship type: By Homology

ncbitaxon 36329 113
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot P49905 165
type: UnificationXref
id: P49905
db: uniprot

uniprot A0A0R4IFU8 7
type: UnificationXref
id: A0A0R4IFU8
db: uniprot

uniprot F1PY87 228
type: UnificationXref
id: F1PY87
db: uniprot

uniprot Q9P3W1 430
type: UnificationXref
id: Q9P3W1
db: uniprot

ncbitaxon 7739 252
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot B2RWS6 225
type: UnificationXref
id: B2RWS6
db: uniprot

Transcription initiation factor IIB 6
type: ProteinReference
xref: uniprot Q9HSB3 503
organism: Halobacterium salinarum

uniprot E2RPG1 450
type: UnificationXref
id: E2RPG1
db: uniprot

Cyclic AMP-responsive element-binding protein 3-like protein 4
type: ProteinReference
xref: PTHR45996:SF2
xref: uniprot Q8TEY5 51
organism: Homo sapiens

General transcription factor IIE, polypeptide 1, alpha
type: ProteinReference
xref: uniprot Q5SQE1 425
organism: Danio rerio

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

CREB s158 sa39 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

hormone s69 sa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: hormone
stoichiometric coefficient: 1.0

CREB3L2 isoform 1
type: ProteinReference
xref: uniprot H2QVG0 28
xref: PTHR46004:SF2
organism: Pan troglodytes

TFIIF
type: ProteinReference
xref: P01394
standard name: Transcription factor IIF
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TFIIF
comment: ENTITY_REFERENCE_NOTES= Long Name: TFIIF Synonym: TF2F,TRANSCRIPTION FACTOR IIF Accession: P01394
member entity reference: RNA polymerase II subunit A C-terminal domain phosphatase

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q7Z7C8 195
organism: Homo sapiens

RNA Polymerase II s8 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA Polymerase II
stoichiometric coefficient: 1.0

uniprot Q92399 322
type: UnificationXref
id: Q92399
db: uniprot

uniprot D3ZY89 129
type: UnificationXref
id: D3ZY89
db: uniprot

Cyclic AMP-responsive element-binding protein 3-like protein 1
type: ProteinReference
xref: uniprot Q66HA2 43
xref: PTHR46004:SF1
organism: Rattus norvegicus

uniprot Q8TU94 553
type: UnificationXref
id: Q8TU94
db: uniprot

TATA box binding protein, isoform CRA_a
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot Q66HB1 544
organism: Rattus norvegicus

DNA-directed RNA polymerase II subunit RPB3
type: ProteinReference
xref: PTHR11800:SF2
xref: uniprot Q3T0Q3 307
organism: Bos taurus

uniprot F7HAK5 73
type: UnificationXref
id: F7HAK5
db: uniprot

Cyclin family protein
type: ProteinReference
xref: uniprot Q1PEE4 479
organism: Arabidopsis thaliana

Complex (CBP/P300/ CREB)
type: Complex
component stoichiometry: HOMODIMER ID 61STOICHIOMETRY ID COMPLEX
component stoichiometry: CBP P300 s153 sa49 STOICHIOMETRY ID COMPLEX
component stoichiometry: CRE s155 a288 STOICHIOMETRY ID COMPLEX
component: CBP/P300
component: CREB
component: CRE
feature: COMPLEX BINDING FEATURE s152 a289 580
feature: COMPLEX BINDING FEATURE s152 a289 578
feature: COMPLEX BINDING FEATURE s152 a289 576
feature: COMPLEX PARTICIPANT BINDING FEATURE s152 a289 609

TATA-box binding protein associated factor 12
type: ProteinReference
xref: uniprot H2PYH5 151
organism: Pan troglodytes

Transcription initiation factor IIA large subunit
type: ProteinReference
xref: uniprot Q9USU9 376
xref: PTHR12694:SF8
organism: Schizosaccharomyces pombe

General transcription factor IIF subunit 2
type: ProteinReference
xref: uniprot P41900 439
organism: Drosophila melanogaster

RNA Polymerase II s8 sa23 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

uniprot Q9P2W1 554
type: UnificationXref
id: Q9P2W1
db: uniprot

uniprot Q15545 170
type: UnificationXref
id: Q15545
db: uniprot

TBP s61 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

TBP
type: Protein
entity reference: TBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s179 sa7 615
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CLY1 273
xref: PTHR11800:SF2
organism: Monodelphis domestica

Candida albicans
type: BioSource
xref: ncbitaxon 237561 118

uniprot Q8SQ19 49
type: UnificationXref
id: Q8SQ19
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot B7Q0X0 447
organism: Ixodes scapularis

TATA box Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa41 557
comment: SPECIES_TYPE=GENE

CRE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s155 a288 577
comment: SPECIES_TYPE=GENE

uniprot Q1K4W6 401
type: UnificationXref
id: Q1K4W6
db: uniprot

uniprot Q9VWY6 216
type: UnificationXref
id: Q9VWY6
db: uniprot

RNA Polymerase II s8 sa23 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G0B2 147
xref: PTHR46469:SF1
organism: Macaca mulatta

Leishmania major
type: BioSource
xref: ncbitaxon 5664 107

TTF2 s184 a293 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TTF2
stoichiometric coefficient: 1.0

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

Complex (CRE/TATA box Promoter)
type: Complex
component stoichiometry: TATA box Promoter s71 sa56 STOICHIOMETRY ID COMPLEX
component stoichiometry: CRE s70 sa55 STOICHIOMETRY ID COMPLEX
component: TATA box Promoter
component: CRE
feature: COMPLEX BINDING FEATURE s127 a306 584
feature: COMPLEX BINDING FEATURE s127 a306 582

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 235

DNA-directed RNA polymerases IV and V subunit 5B
type: ProteinReference
xref: uniprot Q9ZVB9 331
xref: PTHR10535:SF10
organism: Arabidopsis thaliana

CREB
type: Protein
entity reference: CREB
feature: ACTIVE 57
feature: CREB s67 sa54 rs1

uniprot Q39211 306
type: UnificationXref
id: Q39211
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1L1RN70 445
organism: Gallus gallus

uniprot Q7PZ71 314
type: UnificationXref
id: Q7PZ71
db: uniprot

ncbitaxon 39947 200
type: UnificationXref
id: 39947
db: ncbitaxon

RNA Polymerase II s171 a217 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA Polymerase II
stoichiometric coefficient: 1.0

RNA Polymerase II s8 sa23 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.05

TBP
type: Protein
entity reference: TBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa34 605
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot O44743 29
organism: Caenorhabditis elegans

Complex (TFIIE_beta/TFIIE_beta)
type: Complex
component stoichiometry: TFIIEbeta s1 sa5 STOICHIOMETRY ID COMPLEX
component: TFIIEbeta
feature: COMPLEX BINDING FEATURE s41 a114 692

Uncharacterized protein
type: ProteinReference
xref: uniprot C3Y645 251
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR48014:SF24
xref: uniprot Q4QF64 106
organism: Leishmania major

PARTICIPANT STOICHIOMETRY r41 741
type: Stoichiometry
physical entity: Complex (TFIIE_beta/TFIIE_beta)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 743
type: Stoichiometry
physical entity: TFIIE
stoichiometric coefficient: 1.0

CBP/P300
type: Protein
entity reference: CBP/P300
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s153 sa49 579
feature: CBP P300 s153 sa49 rs1
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r41 742
type: Stoichiometry
physical entity: Complex (TFIIEalpha/TFIIEalpha)
stoichiometric coefficient: 1.0

uniprot Q9SS44 506
type: UnificationXref
id: Q9SS44
db: uniprot

uniprot P52657 359
type: UnificationXref
id: P52657
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H5J8 350
xref: PTHR12694:SF7
organism: Macaca mulatta

uniprot O13701 158
type: UnificationXref
id: O13701
db: uniprot

uniprot A0A1L1RN70 445
type: UnificationXref
id: A0A1L1RN70
db: uniprot

uniprot A6H907 510
type: UnificationXref
id: A6H907
db: uniprot

uniprot Q6QDP7 45
type: UnificationXref
id: Q6QDP7
db: uniprot

DNA-directed RNA polymerase II 16 kDa subunit,putative
type: ProteinReference
xref: uniprot O96150 286
organism: Plasmodium falciparum

cAMP-responsive element-binding protein 3-like 3 like
type: ProteinReference
xref: uniprot A0A0R4IB23 3
xref: PTHR45996:SF5
organism: Danio rerio

uniprot D4A898 517
type: UnificationXref
id: D4A898
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PUU3 15
organism: Monodelphis domestica

Homologous-pairing protein 2 homolog
type: ProteinReference
xref: uniprot Q9P2W1 554
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR12716:SF8
xref: uniprot F6YR60 413
organism: Macaca mulatta

TATA-box-binding protein 2
type: ProteinReference
xref: uniprot Q8TU94 553
xref: PTHR10126:SF42
organism: Methanosarcina acetivorans

Receptor s68 sa51 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Receptor
stoichiometric coefficient: 1.0

uniprot Q8K1L0 48
type: UnificationXref
id: Q8K1L0
db: uniprot

Polymerase (RNA) II (DNA directed) polypeptide E
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot Q6DEG5 310
organism: Danio rerio

uniprot Q91XE9 52
type: UnificationXref
id: Q91XE9
db: uniprot

RNA polymerase II subunit A C-terminal domain phosphatase
type: ProteinReference
xref: uniprot Q9P376 410
organism: Schizosaccharomyces pombe

DNA-directed RNA polymerase V subunit 5A
type: ProteinReference
xref: uniprot Q9M1J2 326
xref: PTHR10535:SF2
organism: Arabidopsis thaliana

DNA-directed RNA polymerases I, II, and III subunit RPABC5
type: ProteinReference
xref: uniprot P62876 297
organism: Mus musculus

Transcription factor TFIIE complex alpha subunit
type: ProteinReference
xref: uniprot Q1K7U9 424
organism: Neurospora crassa

uniprot Q63801 187
type: UnificationXref
id: Q63801
db: uniprot

uniprot Q9DBA9 408
type: UnificationXref
id: Q9DBA9
db: uniprot

DNA-directed RNA polymerases I, II, and III subunit RPABC5
type: ProteinReference
xref: uniprot P62875 296
organism: Homo sapiens

Complex CREB CBP P300 s113 a266 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (CREB/CBP/ P300)
stoichiometric coefficient: 1.0

uniprot Q99JX1 202
type: UnificationXref
id: Q99JX1
db: uniprot

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot F7CRN2 274
organism: Xenopus tropicalis

uniprot H2PYH5 151
type: UnificationXref
id: H2PYH5
db: uniprot

TFIIEbeta s1 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIEbeta
stoichiometric coefficient: 2.0

TATA box Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa24 631
comment: SPECIES_TYPE=GENE

uniprot L7N3H9 466
type: UnificationXref
id: L7N3H9
db: uniprot

CBP P300 s54 sa36 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.11
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q9VND0 214
type: UnificationXref
id: Q9VND0
db: uniprot

TFIIE
type: Protein
entity reference: TFIIE
feature: COMPLEX PARTICIPANT BINDING FEATURE s52 sa32 647
comment: SPECIES_TYPE=PROTEIN

uniprot E2R3J4 449
type: UnificationXref
id: E2R3J4
db: uniprot

TATA-box-binding protein 3
type: ProteinReference
xref: uniprot Q8TTZ7 552
xref: PTHR10126:SF42
organism: Methanosarcina acetivorans

uniprot Q8VE65 201
type: UnificationXref
id: Q8VE65
db: uniprot

Transcription termination factor 1
type: ProteinReference
xref: uniprot Q15361 336
organism: Homo sapiens

PTHR13011:SF0
type: RelationshipXref
id: PTHR13011:SF0
db: PANTHER Family
relationship type: By Homology

CBP P300 s159 sa40 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.11
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

ncbitaxon 559292 84
type: UnificationXref
id: 559292
db: ncbitaxon

RNA Polymerase II s26 a132 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

Transcription initiation factor IIE (TFIIE) alpha subunit family protein / general transcription factor TFIIE family protein
type: ProteinReference
xref: uniprot Q9SVG6 431
organism: Arabidopsis thaliana

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r87
controller: cAMP

Transcription regulation by bZIP transcription factor
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__TFIIE_beta_TFIIE_beta_-_Complex__TFIIEalpha_TFIIEalpha_-RIGHT__TFIIE-_r41
pathway component: HETERODIMER_ASSOCIATION_LEFT__TFIIH_complex-_Complex__TFIIF_RNA_Polymerase_II_-_TFIIE-_s161-RIGHT__s168-_r57
pathway component: STATE_TRANSITION_LEFT__s160-_TFIIB-RIGHT__s161-_r54
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__CBP_P300__CREB_-_Complex__TBP_TBP_associated_factors_-_TFIIA_complex-_Complex__CRE_TATA_box_Promoter_-RIGHT__s160-_r86
pathway component: HETERODIMER_ASSOCIATION_LEFT__TFIIFbeta-_TFIIFalpha-RIGHT__TFIIF-_r32
pathway component: STATE_TRANSITION_LEFT__UTP-_s170-_ATP-_GTP-_CTP-RIGHT__s173-_r60
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r87
pathway component: STATE TRANSITION LEFT s181-RIGHT mRNA- RNA Polymerase II- TATA box Promoter gene termination - Complex TBP TBP associated factors - re19
pathway component: STATE_TRANSITION_LEFT__ATP-_CREB-RIGHT__ADP-_CREB-_r63
pathway component: STATE_TRANSITION_LEFT__s169-RIGHT__TFIIH_complex-_s170-_TFIIA_complex-_TFIIB-_r59
pathway component: HETERODIMER_ASSOCIATION_LEFT__TBP_associated_factors-_TBP-RIGHT__Complex__TBP_TBP_associated_factors_-_r36
pathway component: HETERODIMER_ASSOCIATION_LEFT__TFIIF-_RNA_Polymerase_II-RIGHT__Complex__TFIIF_RNA_Polymerase_II_-_r55
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r84
pathway component: HETERODIMER_ASSOCIATION_LEFT__Receptor-_hormone-RIGHT__Complex__Receptor_hormone_-_r83
pathway component: STATE_TRANSITION_LEFT__CREB-RIGHT__CREB-_r66
pathway component: HETERODIMER_ASSOCIATION_LEFT__CREB-_CBP_P300-RIGHT__Complex__CBP_P300__CREB_-_r85
pathway component: STATE_TRANSITION_LEFT__s173-_TTF2-RIGHT__s181-_r61
pathway component: STATE_TRANSITION_LEFT__ATP-_s168-RIGHT__TFIIE-_s169-_ADP-_r58
xref: PANTHER Pathway P00055 1
comment: MODEL_NOTES=Panther Pathway: P00055 bZip General Transcription Factors for RNA Polymerase II The basic-leucine zipper (bZIP) transcription factors of eukaryotic are proteins that contain a basic region mediating sequence-specific DNA-binding followed by a leucine zipper region required for dimerization. This pathway represent the CRE-BP/ATF subfamily of bZIP. Medline=10364255 Medline=1496333 Medline=1876184 Medline=1956398 Medline=7615553 OMIM=189972 PMID: 10364255 PMID: 1496333 PMID: 1876184 PMID: 1956398 PMID: 7615553

uniprot Q5KNS1 109
type: UnificationXref
id: Q5KNS1
db: uniprot

ncbitaxon 367110 102
type: UnificationXref
id: 367110
db: ncbitaxon

General transcription factor IIH subunit 4
type: ProteinReference
xref: uniprot P60027 395
organism: Pan troglodytes

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 25

PARTICIPANT STOICHIOMETRY r54 774
type: Stoichiometry
physical entity: s161
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 773
type: Stoichiometry
physical entity: TFIIB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 772
type: Stoichiometry
physical entity: s160
stoichiometric coefficient: 1.0

uniprot P52434 293
type: UnificationXref
id: P52434
db: uniprot

uniprot F6R525 457
type: UnificationXref
id: F6R525
db: uniprot

General transcription factor IIA subunit 1
type: ProteinReference
xref: uniprot A0A2I3TKG9 344
xref: PTHR12694:SF7
organism: Pan troglodytes

TBP-associated factors
type: Protein
entity reference: TBP-associated factors
feature: COMPLEX PARTICIPANT BINDING FEATURE s178 sa8 617
comment: SPECIES_TYPE=PROTEIN

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: PTHR12716:SF8
xref: uniprot E2R5J2 218
organism: Canis lupus familiaris

uniprot E1BSY6 253
type: UnificationXref
id: E1BSY6
db: uniprot

uniprot Q92793 238
type: UnificationXref
id: Q92793
db: uniprot

AGAP011761-PA
type: ProteinReference
xref: uniprot Q7PZ71 314
organism: Anopheles gambiae

s168
type: Complex
component stoichiometry: Complex CREB CBP P300 s113 a266 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex TATA box Promoter TBP TBP associated factors TFIIA complex TFIIH complex TFIIB RNA Polymerase II TFIIF TFIIE s77 a176 STOICHIOMETRY ID COMPLEX
component: Complex (TATA box Promoter/TBP/ TBP-associated factors/TFIIA complex/ TFIIH complex/TFIIB/ RNA Polymerase II/TFIIF/ TFIIE)
component: Complex (CREB/CBP/ P300)
feature: COMPLEX BINDING FEATURE s168 csa25 628
feature: COMPLEX BINDING FEATURE s168 csa25 648

ncbitaxon 6669 259
type: UnificationXref
id: 6669
db: ncbitaxon

RNA Polymerase II s26 a132 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

ncbitaxon 3702 138
type: UnificationXref
id: 3702
db: ncbitaxon

By Homology
type: RelationshipTypeVocabulary

DNA-directed RNA polymerases I, II, and III subunit RPABC5
type: ProteinReference
xref: uniprot Q32P78 305
organism: Bos taurus

uniprot G5EG49 417
type: UnificationXref
id: G5EG49
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot Q7KQK0 112
organism: Plasmodium falciparum

uniprot P31321 93
type: UnificationXref
id: P31321
db: uniprot

uniprot H2Q908 463
type: UnificationXref
id: H2Q908
db: uniprot

TTF2
type: ProteinReference
xref: P01389
standard name: Trascription termination factor RNA polymerase II
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: TTF2 Synonym: TRANSCRIPTION TERMINATION FACTOR RNA POLYMERASE II,human factor 2 Accession: P01389
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TTF2
member entity reference: Transcription termination factor 1a, mitochondrial
member entity reference: Uncharacterized protein
member entity reference: Transcription termination factor 1
member entity reference: Transcription termination factor 2
member entity reference: Transcription termination factor 1b, mitochondrial
member entity reference: TTF1 isoform 2
member entity reference: Mitochondrial transcription termination factor 2
member entity reference: Transcription termination factor 2, mitochondrial

CREB
type: ProteinReference
xref: P01383
standard name: cAMP response element binding protein
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.CREB
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: CREB Synonym: cAMP responsive element binding protein Accession: P01383
member entity reference: Cyclic AMP-responsive element-binding protein 3
member entity reference: Cyclic AMP-responsive element-binding protein 3-like protein 1
member entity reference: Cyclic AMP-responsive element-binding protein 3-like protein 2
member entity reference: Cyclic AMP-responsive element-binding protein 3-like protein 3
member entity reference: Cyclic AMP-responsive element-binding protein 5
member entity reference: cAMP-responsive element-binding protein 3-like 3 like
member entity reference: cAMP-responsive element modulator
member entity reference: Cyclic AMP response element-binding protein B
member entity reference: Cyclic AMP-responsive element-binding protein 3-like protein 4
member entity reference: cAMP responsive element binding protein 3 like 1
member entity reference: CREB3L4 isoform 1
member entity reference: CREB3L2 protein
member entity reference: cAMP-responsive element-binding protein 1b
member entity reference: CREB3L3 isoform 2
member entity reference: Uncharacterized protein
member entity reference: CREB3L1 isoform 1
member entity reference: Similar to cAMP responsive element binding protein 5 (Predicted)
member entity reference: CREB3L2 isoform 1
member entity reference: Atf6, isoform C
member entity reference: Cyclic AMP-responsive element-binding protein 1
member entity reference: cAMP-responsive element-binding protein 1
member entity reference: CREB Homolog
member entity reference: ATF (cAMP-dependent transcription factor) family
member entity reference: Cyclic AMP response element-binding protein A
member entity reference: cAMP responsive element binding protein 1

uniprot F7E5B3 144
type: UnificationXref
id: F7E5B3
db: uniprot

uniprot H2QF47 380
type: UnificationXref
id: H2QF47
db: uniprot

uniprot F6QZ41 433
type: UnificationXref
id: F6QZ41
db: uniprot

TFIIA-alpha and beta-like factor
type: ProteinReference
xref: uniprot Q8R4I4 369
organism: Mus musculus

MGC146599 protein
type: ProteinReference
xref: uniprot Q1ECU1 300
organism: Xenopus tropicalis

uniprot P29747 34
type: UnificationXref
id: P29747
db: uniprot

Atf6, isoform C
type: ProteinReference
xref: uniprot Q8SX87 50
organism: Drosophila melanogaster

RNA Polymerase II s26 a132 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

uniprot H3FFR1 279
type: UnificationXref
id: H3FFR1
db: uniprot

uniprot Q9VKV8 507
type: UnificationXref
id: Q9VKV8
db: uniprot

uniprot G7NDH4 22
type: UnificationXref
id: G7NDH4
db: uniprot

uniprot P53040 167
type: UnificationXref
id: P53040
db: uniprot

uniprot Q9DBC7 116
type: UnificationXref
id: Q9DBC7
db: uniprot

uniprot Q9D902 224
type: UnificationXref
id: Q9D902
db: uniprot

uniprot Q7ZV11 319
type: UnificationXref
id: Q7ZV11
db: uniprot

RNA Polymerase II s26 a132 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.05

uniprot F6VJI3 19
type: UnificationXref
id: F6VJI3
db: uniprot

CRE s155 a288 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRE
stoichiometric coefficient: 1.0

uniprot Q9VP40 215
type: UnificationXref
id: Q9VP40
db: uniprot

uniprot Q7SEH7 366
type: UnificationXref
id: Q7SEH7
db: uniprot

Transcription termination factor 2, mitochondrial
type: ProteinReference
xref: uniprot Q49AM1 337
xref: PTHR15437:SF1
organism: Homo sapiens

uniprot Q15572 171
type: UnificationXref
id: Q15572
db: uniprot

General transcription factor IIF subunit 2
type: ProteinReference
xref: uniprot Q01750 440
organism: Rattus norvegicus

PTHR12716:SF8
type: RelationshipXref
id: PTHR12716:SF8
db: PANTHER Family
relationship type: By Homology

uniprot Q5FVM5 40
type: UnificationXref
id: Q5FVM5
db: uniprot

TFIIFalpha
type: Protein
entity reference: TFIIFalpha
comment: SPECIES_TYPE=PROTEIN

uniprot H2QY30 335
type: UnificationXref
id: H2QY30
db: uniprot

uniprot F6SMC2 269
type: UnificationXref
id: F6SMC2
db: uniprot

uniprot B0BLT7 127
type: UnificationXref
id: B0BLT7
db: uniprot

DNA-directed RNA polymerases II, IV and V subunit 3
type: ProteinReference
xref: PTHR11800:SF2
xref: uniprot Q39211 306
organism: Arabidopsis thaliana

uniprot Q6NZA9 188
type: UnificationXref
id: Q6NZA9
db: uniprot

TAF1C isoform 5
type: ProteinReference
xref: uniprot H2QBM1 152
xref: PTHR15319:SF1
organism: Pan troglodytes

CRE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa55 583
comment: SPECIES_TYPE=GENE

Transcription initiation factor IIB-2
type: ProteinReference
xref: uniprot Q9SS44 506
organism: Arabidopsis thaliana

uniprot H2R032 434
type: UnificationXref
id: H2R032
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 20

Transcription initiation factor TFIID subunit 7
type: ProteinReference
xref: uniprot O13701 158
organism: Schizosaccharomyces pombe

Uncharacterized protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F7E905 231
organism: Monodelphis domestica

uniprot P36600 96
type: UnificationXref
id: P36600
db: uniprot

General transcription facter IIA subunit 1 variant 1
type: ProteinReference
xref: PTHR12694:SF7
xref: uniprot A1IIE6 345
organism: Gallus gallus

RNA Polymerase II
type: Protein
entity reference: RNA Polymerase II
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa30 643
feature: RNA Polymerase II s48 sa30 rs1
feature: RNA Polymerase II s48 sa30 rs4
feature: RNA Polymerase II s48 sa30 rs2
feature: RNA Polymerase II s48 sa30 rs3
comment: SPECIES_TYPE=PROTEIN

uniprot E2RLD6 13
type: UnificationXref
id: E2RLD6
db: uniprot

uniprot Q09191 298
type: UnificationXref
id: Q09191
db: uniprot

DNA-directed RNA polymerases II, IV and V subunit 9B
type: ProteinReference
xref: uniprot Q8L5V0 321
organism: Arabidopsis thaliana

uniprot O96881 221
type: UnificationXref
id: O96881
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot E2RRD1 67
organism: Canis lupus familiaris

Complex TATA box Promoter TBP TBP associated factors TFIIA complex TFIIH complex TFIIB RNA Polymerase II TFIIF TFIIE s77 a176 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (TATA box Promoter/TBP/ TBP-associated factors/TFIIA complex/ TFIIH complex/TFIIB/ RNA Polymerase II/TFIIF/ TFIIE)
stoichiometric coefficient: 1.0

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 494

Protein kinase cAMP-dependent type I regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot F6R7N8 71
organism: Monodelphis domestica

TATA-box-binding protein
type: ProteinReference
xref: uniprot P13393 529
xref: PTHR10126:SF42
organism: Saccharomyces cerevisiae

UTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CBP P300 s153 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CBP/P300
stoichiometric coefficient: 1.0

uniprot E2RQ42 256
type: UnificationXref
id: E2RQ42
db: uniprot

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: uniprot Q7Q7C7 427
xref: PTHR12716:SF8
organism: Anopheles gambiae

General transcription factor IIH subunit 4
type: ProteinReference
xref: uniprot A6H7G8 387
organism: Bos taurus

Complex TBP TBP associated factors s185 a129 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (TBP/TBP-associated factors)
stoichiometric coefficient: 1.0

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: uniprot O08950 353
organism: Rattus norvegicus

Complex (CBP/P300/ CREB)
type: Complex
component stoichiometry: HOMODIMER ID 60STOICHIOMETRY ID COMPLEX
component stoichiometry: CBP P300 s66 sa53 STOICHIOMETRY ID COMPLEX
component: CBP/P300
component: CREB
feature: COMPLEX BINDING FEATURE s118 a305 574
feature: COMPLEX BINDING FEATURE s118 a305 572

uniprot Q7SAL1 318
type: UnificationXref
id: Q7SAL1
db: uniprot

ncbitaxon 7165 115
type: UnificationXref
id: 7165
db: ncbitaxon

AGAP010958-PA
type: ProteinReference
xref: uniprot Q7PFI3 548
xref: PTHR10126:SF42
organism: Anopheles gambiae

Transcription initiation factor IIA subunit 1
type: ProteinReference
xref: PTHR12694:SF7
xref: uniprot O08949 352
organism: Rattus norvegicus

uniprot Q9LIA6 504
type: UnificationXref
id: Q9LIA6
db: uniprot

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r84
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 711
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 710
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

Transcription termination factor 2
type: ProteinReference
xref: uniprot Q5NC05 338
organism: Mus musculus

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 497

Transcription initiation factor TFIID subunit 7
type: ProteinReference
xref: uniprot Q9R1C0 209
organism: Mus musculus

RNA Polymerase II s16 a29 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

uniprot H2Q045 24
type: UnificationXref
id: H2Q045
db: uniprot

DNA-directed RNA polymerase V subunit 5C
type: ProteinReference
xref: PTHR10535:SF12
xref: uniprot Q9M1H8 325
organism: Arabidopsis thaliana

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot P12849 89
organism: Mus musculus

uniprot Q9HSB3 503
type: UnificationXref
id: Q9HSB3
db: uniprot

TFIIE s52 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIE
stoichiometric coefficient: 1.0

TATA box-binding protein-like protein 1
type: ProteinReference
xref: PTHR10126:SF55
xref: uniprot Q32LB1 542
organism: Bos taurus

DNA-directed RNA polymerases I, II, and III subunit RPABC2
type: ProteinReference
xref: PTHR10773:SF12
xref: uniprot O88828 285
organism: Rattus norvegicus

uniprot A0A1D5REN8 122
type: UnificationXref
id: A0A1D5REN8
db: uniprot

uniprot F1MAS3 261
type: UnificationXref
id: F1MAS3
db: uniprot

uniprot E2RFN3 133
type: UnificationXref
id: E2RFN3
db: uniprot

uniprot Q49AM1 337
type: UnificationXref
id: Q49AM1
db: uniprot

CBP P300 s165 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CBP/P300
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

PTHR10535:SF10
type: RelationshipXref
id: PTHR10535:SF10
db: PANTHER Family
relationship type: By Homology

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q5ZMS1 184
organism: Gallus gallus

PTHR10535:SF12
type: RelationshipXref
id: PTHR10535:SF12
db: PANTHER Family
relationship type: By Homology

TFIIEalpha s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIEalpha
stoichiometric coefficient: 2.0

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot F6WM87 72
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot F6SEF6 521
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r32 725
type: Stoichiometry
physical entity: TFIIFbeta
stoichiometric coefficient: 1.0

DNA-directed RNA polymerase II subunit RPB3
type: ProteinReference
xref: uniprot P19387 289
xref: PTHR11800:SF2
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r32 727
type: Stoichiometry
physical entity: TFIIF
stoichiometric coefficient: 1.0

RNA Polymerase II s16 a29 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.05

PARTICIPANT STOICHIOMETRY r32 726
type: Stoichiometry
physical entity: TFIIFalpha
stoichiometric coefficient: 1.0

DNA-directed RNA polymerases I, II, and III subunit RPABC1
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot P19388 290
organism: Homo sapiens

uniprot Q8L5V0 321
type: UnificationXref
id: Q8L5V0
db: uniprot

uniprot O70422 393
type: UnificationXref
id: O70422
db: uniprot

RNA Polymerase II
type: Protein
entity reference: RNA Polymerase II
feature: RNA Polymerase II s8 sa23 rs4
feature: RNA Polymerase II s8 sa23 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa23 691
feature: RNA Polymerase II s8 sa23 rs3
feature: RNA Polymerase II s8 sa23 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot Q17QQ4 174
type: UnificationXref
id: Q17QQ4
db: uniprot

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q6P0T2 189
organism: Danio rerio

RNA Polymerase II s16 a29 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

uniprot Q7KQK0 112
type: UnificationXref
id: Q7KQK0
db: uniprot

TFIIEalpha
type: Protein
entity reference: TFIIEalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 587
comment: SPECIES_TYPE=PROTEIN

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 513

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 30

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: PTHR10966:SF5
xref: uniprot H2Q9J2 351
organism: Pan troglodytes

Pristionchus pacificus
type: BioSource
xref: ncbitaxon 54126 280

uniprot Q9USU9 376
type: UnificationXref
id: Q9USU9
db: uniprot

PTHR10535:SF15
type: RelationshipXref
id: PTHR10535:SF15
db: PANTHER Family
relationship type: By Homology

uniprot F7BXN9 272
type: UnificationXref
id: F7BXN9
db: uniprot

General transcription factor IIF subunit 2
type: ProteinReference
xref: PTHR10445:SF0
xref: uniprot Q8R0A0 442
organism: Mus musculus

uniprot Q02939 397
type: UnificationXref
id: Q02939
db: uniprot

TFIIF
type: Protein
entity reference: TFIIF
comment: SPECIES_TYPE=PROTEIN

RNA Polymerase II s16 a29 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

CREB
type: Complex
component stoichiometry: CREB s103 a237 STOICHIOMETRY ID COMPLEX
component: CREB
feature: ACTIVE 57

uniprot F1NHV9 262
type: UnificationXref
id: F1NHV9
db: uniprot

CREB
type: Complex
component stoichiometry: CREB s53 sa35 STOICHIOMETRY ID COMPLEX
component: CREB
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s53 sa35 625

uniprot A7YY66 10
type: UnificationXref
id: A7YY66
db: uniprot

CREB
type: Complex
component stoichiometry: CREB s67 sa54 STOICHIOMETRY ID COMPLEX
component: CREB
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa54 575

CREB
type: Complex
component stoichiometry: CREB s154 sa50 STOICHIOMETRY ID COMPLEX
component: CREB
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s154 sa50 581

RNA Polymerase II s180 a122 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA Polymerase II
stoichiometric coefficient: 1.0

CREB
type: Complex
component stoichiometry: CREB s158 sa39 STOICHIOMETRY ID COMPLEX
component: CREB
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s158 sa39 683

CREB
type: Complex
component stoichiometry: CREB s164 sa37 STOICHIOMETRY ID COMPLEX
component: CREB
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s164 sa37 665

uniprot P00515 80
type: UnificationXref
id: P00515
db: uniprot

uniprot F6Y6M6 389
type: UnificationXref
id: F6Y6M6
db: uniprot

TATA box-binding protein-like protein 1
type: ProteinReference
xref: PTHR10126:SF55
xref: uniprot P62340 537
organism: Mus musculus

DNA-directed RNA polymerase II subunit RPB3
type: ProteinReference
xref: PTHR11800:SF2
xref: uniprot P16370 288
organism: Saccharomyces cerevisiae

HETERODIMER_ASSOCIATION_LEFT__TFIIH_complex-_Complex__TFIIF_RNA_Polymerase_II_-_TFIIE-_s161-RIGHT__s168-_r57
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 757
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 755
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 756
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 754
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 758
left: TFIIH complex
left: s161
left: Complex (TFIIF/RNA Polymerase II)
left: TFIIE
interaction type: HETERODIMER_ASSOCIATION
right: s168

ncbitaxon 6945 250
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot F6STP6 141
type: UnificationXref
id: F6STP6
db: uniprot

uniprot B2D6P4 514
type: UnificationXref
id: B2D6P4
db: uniprot

PARTICIPANT STOICHIOMETRY r55 768
type: Stoichiometry
physical entity: Complex (TFIIF/RNA Polymerase II)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r55 767
type: Stoichiometry
physical entity: RNA Polymerase II
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r55 766
type: Stoichiometry
physical entity: TFIIF
stoichiometric coefficient: 1.0

uniprot F1MII0 347
type: UnificationXref
id: F1MII0
db: uniprot

PTHR10917:SF0
type: RelationshipXref
id: PTHR10917:SF0
db: PANTHER Family
relationship type: By Homology

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 110

Transcription initiation factor IIA subunit 1
type: ProteinReference
xref: uniprot P52654 357
xref: PTHR12694:SF8
organism: Drosophila melanogaster

TATA-box-binding protein 1
type: ProteinReference
xref: uniprot P52653 536
xref: PTHR10126:SF42
organism: Entamoeba histolytica

Transcription initiation factor IIA subunit 1
type: ProteinReference
xref: PTHR12694:SF7
xref: uniprot P52655 358
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r60 737
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r85 769
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r60 736
type: Stoichiometry
physical entity: s170
stoichiometric coefficient: 1.0

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: PTHR10966:SF5
xref: uniprot P52657 359
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r60 735
type: Stoichiometry
physical entity: UTP
stoichiometric coefficient: 1.0

uniprot A1IIE6 345
type: UnificationXref
id: A1IIE6
db: uniprot

PARTICIPANT STOICHIOMETRY r60 739
type: Stoichiometry
physical entity: CTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r60 738
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

General transcription factor IIE subunit 1
type: ProteinReference
xref: uniprot P29083 421
xref: PTHR13097:SF7
organism: Homo sapiens

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: PTHR12716:SF8
xref: uniprot P29084 422
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r85 770
type: Stoichiometry
physical entity: CBP/P300
stoichiometric coefficient: 1.0

Transcription initiation factor IIF subunit beta
type: ProteinReference
xref: uniprot O94424 436
organism: Schizosaccharomyces pombe

TATA box Promoter s56 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TATA box Promoter
stoichiometric coefficient: 1.0

RCG49239
type: ProteinReference
xref: uniprot B0BN78 128
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r60 740
type: Stoichiometry
physical entity: s173
stoichiometric coefficient: 1.0

General transcription and DNA repair factor IIH subunit tfb2
type: ProteinReference
xref: uniprot P87303 396
organism: Schizosaccharomyces pombe

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 252

Transcription initiation factor IIB 4
type: ProteinReference
xref: uniprot Q9HR45 502
organism: Halobacterium salinarum

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y5K3 509
organism: Strongylocentrotus purpuratus

TATA box Promoter gene termination
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s182 a126 595
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY r85 771
type: Stoichiometry
physical entity: Complex (CBP/P300/ CREB)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1B8D6 226
xref: PTHR13808:SF29
organism: Bos taurus

Cyclic AMP-responsive element-binding protein 3
type: ProteinReference
xref: uniprot G7NFD1 23
xref: PTHR45996:SF4
organism: Macaca mulatta

TFIIA complex
type: Protein
entity reference: TFIIA complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa27 637
comment: SPECIES_TYPE=PROTEIN

Complex (TBP-associated factors/TBP/ TATA box Promoter/TFIIA complex)
type: Complex
component stoichiometry: TBP associated factors s13 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBP s14 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIA complex s18 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: TATA box Promoter s17 sa15 STOICHIOMETRY ID COMPLEX
component: TBP-associated factors
component: TATA box Promoter
component: TBP
component: TFIIA complex
feature: COMPLEX BINDING FEATURE s55 a141 672
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 a141 679
feature: COMPLEX BINDING FEATURE s55 a141 674
feature: COMPLEX BINDING FEATURE s55 a141 676
feature: COMPLEX BINDING FEATURE s55 a141 670

STATE_TRANSITION_LEFT__CREB-RIGHT__CREB-_r66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 719
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 718
left: CREB
interaction type: STATE_TRANSITION
right: CREB

TATA box Promoter gene
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 a121 697
comment: SPECIES_TYPE=GENE

Cyclic AMP response element-binding protein A
type: ProteinReference
xref: uniprot P29747 34
organism: Drosophila melanogaster

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot P32085 535
organism: Caenorhabditis elegans

RE34924p
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot Q7JZF5 312
organism: Drosophila melanogaster

uniprot P32774 356
type: UnificationXref
id: P32774
db: uniprot

Polymerase (RNA) II (DNA directed) polypeptide L
type: ProteinReference
xref: uniprot Q28GI6 303
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR15437:SF1
xref: uniprot F6XFN3 333
organism: Macaca mulatta

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot Q92793 238
organism: Homo sapiens

Plant-specific TFIIB-related protein 2
type: ProteinReference
xref: uniprot Q9LIA6 504
organism: Arabidopsis thaliana

TATA box Promoter gene s28 a121 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TATA box Promoter gene
stoichiometric coefficient: 1.0

TATA-box-binding protein-like 1
type: ProteinReference
xref: PTHR10126:SF55
xref: uniprot D4A898 517
organism: Rattus norvegicus

Protein CBR-TBP-1
type: ProteinReference
xref: uniprot A8X861 512
xref: PTHR10126:SF42
organism: Caenorhabditis briggsae

DNA-directed RNA polymerases I, II, and III subunit RPABC1
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot P20434 291
organism: Saccharomyces cerevisiae

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot P29052 468
organism: Drosophila melanogaster

uniprot Q9D3R9 203
type: UnificationXref
id: Q9D3R9
db: uniprot

CREB s53 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

uniprot H2QW11 465
type: UnificationXref
id: H2QW11
db: uniprot

ncbitaxon 9598 25
type: UnificationXref
id: 9598
db: ncbitaxon

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot O13749 467
organism: Schizosaccharomyces pombe

Transcription initiation factor TFIID subunit 9
type: ProteinReference
xref: uniprot Q27272 176
organism: Drosophila melanogaster

uniprot H2QF07 27
type: UnificationXref
id: H2QF07
db: uniprot

uniprot F4HVA6 137
type: UnificationXref
id: F4HVA6
db: uniprot

Transcription factor IIIB 70 kDa subunit
type: ProteinReference
xref: uniprot P29056 470
organism: Saccharomyces cerevisiae

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot P29055 469
organism: Saccharomyces cerevisiae

TBP-associated factors
type: Protein
entity reference: TBP-associated factors
comment: SPECIES_TYPE=PROTEIN

CRE s105 a284 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRE
stoichiometric coefficient: 1.0

uniprot F6XFN3 333
type: UnificationXref
id: F6XFN3
db: uniprot

uniprot P37382 292
type: UnificationXref
id: P37382
db: uniprot

ncbitaxon 684364 455
type: UnificationXref
id: 684364
db: ncbitaxon

uniprot P29056 470
type: UnificationXref
id: P29056
db: uniprot

uniprot E9GMZ1 451
type: UnificationXref
id: E9GMZ1
db: uniprot

hormone
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa52 621
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Transcription factor IIIB 50 kDa subunit
type: ProteinReference
xref: uniprot Q3UAW9 480
organism: Mus musculus

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 483

uniprot Q6MG20 404
type: UnificationXref
id: Q6MG20
db: uniprot

uniprot P13984 437
type: UnificationXref
id: P13984
db: uniprot

uniprot Q9S7R9 210
type: UnificationXref
id: Q9S7R9
db: uniprot

uniprot F7EEK0 459
type: UnificationXref
id: F7EEK0
db: uniprot

General transcription factor IIH subunit 3
type: ProteinReference
xref: uniprot Q13889 400
organism: Homo sapiens

uniprot Q8C176 196
type: UnificationXref
id: Q8C176
db: uniprot

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: uniprot Q6DEQ4 364
organism: Xenopus tropicalis

uniprot Q28J24 177
type: UnificationXref
id: Q28J24
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot E2RRA1 66
xref: PTHR11635:SF156
organism: Canis lupus familiaris

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot Q9HEW1 117
xref: PTHR11635:SF152
organism: Candida albicans

uniprot Q80ZM7 368
type: UnificationXref
id: Q80ZM7
db: uniprot

uniprot P35269 381
type: UnificationXref
id: P35269
db: uniprot

uniprot D3ZBH0 11
type: UnificationXref
id: D3ZBH0
db: uniprot

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot Q8ZWS3 496
organism: Pyrobaculum aerophilum

Complex (TBP/TBP-associated factors)
type: Complex
component stoichiometry: TBP s186 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBP associated factors s187 sa10 STOICHIOMETRY ID COMPLEX
component: TBP
component: TBP-associated factors
feature: COMPLEX PARTICIPANT BINDING FEATURE s185 a129 593
feature: COMPLEX BINDING FEATURE s185 a129 590
feature: COMPLEX BINDING FEATURE s185 a129 588

TFIIF s7 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIF
stoichiometric coefficient: 1.0

uniprot Q6JHU9 237
type: UnificationXref
id: Q6JHU9
db: uniprot

General transcription factor IIH subunit 4
type: ProteinReference
xref: uniprot Q92759 407
organism: Homo sapiens

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P13861 90
organism: Homo sapiens

Cilia and flagella associated protein 20
type: ProteinReference
xref: uniprot F7F9P9 460
organism: Ornithorhynchus anatinus

CRE s166 a259 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRE
stoichiometric coefficient: 1.0

TBP associated factors s62 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP-associated factors
stoichiometric coefficient: 1.0

Transcription initiation factor TFIID subunit 2
type: ProteinReference
xref: uniprot Q8LPF0 198
organism: Arabidopsis thaliana

RNA
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 a128 599
comment: SPECIES_TYPE=RNA

uniprot W4YRI6 119
type: UnificationXref
id: W4YRI6
db: uniprot

Cyclic AMP-responsive element-binding protein 3-like protein 2
type: ProteinReference
xref: uniprot Q70SY1 46
xref: PTHR46004:SF2
organism: Homo sapiens

HOMODIMER ID 63STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

uniprot F6WM87 72
type: UnificationXref
id: F6WM87
db: uniprot

Cilia- and flagella-associated protein 20
type: ProteinReference
xref: uniprot Q8BTU1 491
organism: Mus musculus

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: PTHR12716:SF8
xref: uniprot G5EG47 220
organism: Caenorhabditis elegans

uniprot F1LNY6 135
type: UnificationXref
id: F1LNY6
db: uniprot

General Transcription Factor homolog
type: ProteinReference
xref: uniprot G5EG49 417
organism: Caenorhabditis elegans

TFIIF
type: Protein
entity reference: TFIIF
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa31 645
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 8364 18
type: UnificationXref
id: 8364
db: ncbitaxon

TATA-box binding protein like 1
type: ProteinReference
xref: uniprot F6UVN1 522
xref: PTHR10126:SF55
organism: Ornithorhynchus anatinus

uniprot Q27272 176
type: UnificationXref
id: Q27272
db: uniprot

CREB-binding protein isoform a
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F6RRA8 229
organism: Macaca mulatta

uniprot F2Z4H3 264
type: UnificationXref
id: F2Z4H3
db: uniprot

uniprot E2RRD1 67
type: UnificationXref
id: E2RRD1
db: uniprot

uniprot Q7Q0D5 315
type: UnificationXref
id: Q7Q0D5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10126:SF55
xref: uniprot F7F0J5 525
organism: Monodelphis domestica

TFIIEalpha
type: ProteinReference
xref: P01398
standard name: Transcription factor IIE, alpha
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TFIIE_alpha_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: General transcription factor IIE subunit 1
member entity reference: GTF2E1 isoform 2
member entity reference: General Transcription Factor homolog
member entity reference: General transcription factor II E, polypeptide 1 (Alpha subunit)
member entity reference: GH11150p

uniprot P36145 222
type: UnificationXref
id: P36145
db: uniprot

TBP-associated factors
type: Protein
entity reference: TBP-associated factors
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa33 603
comment: SPECIES_TYPE=PROTEIN

uniprot F2Z4C9 263
type: UnificationXref
id: F2Z4C9
db: uniprot

TBP
type: Protein
entity reference: TBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa25 633
comment: SPECIES_TYPE=PROTEIN

uniprot O74462 159
type: UnificationXref
id: O74462
db: uniprot

uniprot F6SEF6 521
type: UnificationXref
id: F6SEF6
db: uniprot

uniprot Q8BTU1 491
type: UnificationXref
id: Q8BTU1
db: uniprot

Cyclic AMP-responsive element-binding protein 3-like protein 4
type: ProteinReference
xref: uniprot Q9D2A5 54
xref: PTHR45996:SF2
organism: Mus musculus

Polymerase (RNA) II (DNA directed) polypeptide C
type: ProteinReference
xref: PTHR11800:SF2
xref: uniprot Q7ZV11 319
organism: Danio rerio

uniprot F1MD32 227
type: UnificationXref
id: F1MD32
db: uniprot

uniprot Q9Y6A4 508
type: UnificationXref
id: Q9Y6A4
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 259

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q9DBC7 116
organism: Mus musculus

DNA-directed RNA polymerases I, II, and III subunit RPABC1
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot Q9N5K2 327
organism: Caenorhabditis elegans

CBP/P300
type: ProteinReference
xref: P01387
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.CBP/P300
comment: ENTITY_REFERENCE_NOTES= Long Name: CBP/P300 Synonym: CREB-binding protein Accession: P01387
member entity reference: Histone acetyltransferase p300
member entity reference: CREB binding protein
member entity reference: CREB-binding protein
member entity reference: Histone acetyltransferase HAC4
member entity reference: CREB-binding protein isoform a
member entity reference: Uncharacterized protein
member entity reference: E1A binding protein p300

Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot Q19826 299
organism: Caenorhabditis elegans

Cyclin/Brf1-like TBP-binding protein
type: ProteinReference
xref: uniprot Q0WVQ3 478
organism: Arabidopsis thaliana

RNA Polymerase II s48 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA Polymerase II
stoichiometric coefficient: 1.0

uniprot H2Q6S6 334
type: UnificationXref
id: H2Q6S6
db: uniprot

CREB s154 sa50 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

DNA-directed RNA polymerases I, II, and III subunit RPABC5
type: ProteinReference
xref: uniprot Q9VC49 329
organism: Drosophila melanogaster

uniprot P00514 79
type: UnificationXref
id: P00514
db: uniprot

Complex TBP associated factors TBP s100 a215 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (TBP-associated factors/TBP)
stoichiometric coefficient: 1.0

Transcription initiation factor IIE subunit alpha
type: ProteinReference
xref: uniprot P36100 423
organism: Saccharomyces cerevisiae

PTHR46338:SF7
type: RelationshipXref
id: PTHR46338:SF7
db: PANTHER Family
relationship type: By Homology

TFIIF
type: Protein
entity reference: TFIIF
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa43 561
comment: SPECIES_TYPE=PROTEIN

uniprot Q0WVQ3 478
type: UnificationXref
id: Q0WVQ3
db: uniprot

PTHR46338:SF1
type: RelationshipXref
id: PTHR46338:SF1
db: PANTHER Family
relationship type: By Homology

TFIIH complex s63 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIH complex
stoichiometric coefficient: 1.0

TATA box-binding protein-like protein 1
type: ProteinReference
xref: uniprot P62380 538
xref: PTHR10126:SF55
organism: Homo sapiens

RNA polymerase II subunit F
type: ProteinReference
xref: PTHR10773:SF12
xref: uniprot F7CX67 275
organism: Ornithorhynchus anatinus

uniprot Q8R0A0 442
type: UnificationXref
id: Q8R0A0
db: uniprot

uniprot A0A1D5PCI4 64
type: UnificationXref
id: A0A1D5PCI4
db: uniprot

General transcription factor IIF subunit 1
type: ProteinReference
xref: uniprot B1H3B7 379
organism: Xenopus tropicalis

ncbitaxon 243232 483
type: UnificationXref
id: 243232
db: ncbitaxon

General transcription factor IIH subunit 3
type: ProteinReference
xref: uniprot Q05B56 398
organism: Bos taurus

Transcription factor IIIB 60 kDa subunit
type: ProteinReference
xref: uniprot Q9P6R0 505
organism: Schizosaccharomyces pombe

General transcription factor IIH subunit 1
type: ProteinReference
xref: uniprot Q9DBA9 408
organism: Mus musculus

uniprot F6QGV9 348
type: UnificationXref
id: F6QGV9
db: uniprot

uniprot E1BEL5 518
type: UnificationXref
id: E1BEL5
db: uniprot

Cilia- and flagella-associated protein 20
type: ProteinReference
xref: uniprot Q9VKV8 507
organism: Drosophila melanogaster

TATA-box binding protein associated factor 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot E2RN76 134
organism: Canis lupus familiaris

CREB s102 a227 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

uniprot E7FDD7 257
type: UnificationXref
id: E7FDD7
db: uniprot

uniprot O44743 29
type: UnificationXref
id: O44743
db: uniprot

General transcription factor IIH subunit 4
type: ProteinReference
xref: uniprot F7F0D8 391
organism: Monodelphis domestica

TATA box-binding protein-like protein 1
type: ProteinReference
xref: PTHR10126:SF55
xref: uniprot Q6DIY4 545
organism: Xenopus tropicalis

GH07456p
type: ProteinReference
xref: uniprot O97183 287
xref: PTHR11800:SF2
organism: Drosophila melanogaster

uniprot Q58192 482
type: UnificationXref
id: Q58192
db: uniprot

uniprot Q6SJ96 547
type: UnificationXref
id: Q6SJ96
db: uniprot

POLR2E isoform 1
type: ProteinReference
xref: uniprot K7CNC1 281
organism: Pan troglodytes

uniprot Q32P78 305
type: UnificationXref
id: Q32P78
db: uniprot

uniprot Q6DEQ4 364
type: UnificationXref
id: Q6DEQ4
db: uniprot

Transcription initiation factor IIA subunit 1
type: ProteinReference
xref: uniprot Q99PM3 371
xref: PTHR12694:SF7
organism: Mus musculus

TFIIEbeta
type: ProteinReference
xref: P01386
standard name: Transcription factor IIE, beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TFIIE_beta
comment: ENTITY_REFERENCE_NOTES=
member entity reference: General transcription factor IIE subunit 2
member entity reference: Transcription initiation factor IIE subunit beta
member entity reference: General transcription factor IIE, polypeptide 2, beta

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot Q1PEE4 479
type: UnificationXref
id: Q1PEE4
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 78

PTHR10773:SF12
type: RelationshipXref
id: PTHR10773:SF12
db: PANTHER Family
relationship type: By Homology

Transcription initiation factor TFIID subunit 12
type: ProteinReference
xref: uniprot Q3T174 179
organism: Bos taurus

ncbitaxon 45351 245
type: UnificationXref
id: 45351
db: ncbitaxon

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: PTHR10966:SF0
xref: uniprot Q32L01 361
organism: Bos taurus

uniprot O59922 77
type: UnificationXref
id: O59922
db: uniprot

General transcription factor IIH subunit 1
type: ProteinReference
xref: uniprot A0A0G2JWQ0 385
organism: Rattus norvegicus

uniprot A0A1D5R7P4 378
type: UnificationXref
id: A0A1D5R7P4
db: uniprot

ncbitaxon 6239 30
type: UnificationXref
id: 6239
db: ncbitaxon

TATA box-binding protein-like protein 1
type: ProteinReference
xref: uniprot A6H914 511
xref: PTHR10126:SF55
organism: Pan troglodytes

TFIIF s58 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIF
stoichiometric coefficient: 1.0

TFIIFbeta
type: ProteinReference
xref: P01396
standard name: Transcription factor IIF, beta
comment: ENTITY_REFERENCE_NOTES= Long Name: TFIIFbeta Synonym: BETA SUBUNIT,RAP30,TF2F2,TFIIF BETA,TRANSCRIPTION FACTOR IIF Accession: P01396
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TFIIF_beta_
member entity reference: General transcription factor IIF subunit 2
member entity reference: Transcription initiation factor IIF subunit beta
member entity reference: Uncharacterized protein

Transcription initiation factor TFIID subunit 2
type: ProteinReference
xref: uniprot P23255 161
organism: Saccharomyces cerevisiae

uniprot P31323 94
type: UnificationXref
id: P31323
db: uniprot

uniprot H9ERZ5 435
type: UnificationXref
id: H9ERZ5
db: uniprot

AGAP004233-PA
type: ProteinReference
xref: uniprot Q7QB20 489
organism: Anopheles gambiae

uniprot Q1JPY4 539
type: UnificationXref
id: Q1JPY4
db: uniprot

Cilia- and flagella-associated protein 20
type: ProteinReference
xref: uniprot Q5ZHP3 485
organism: Gallus gallus

hormone
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Transcription initiation factor IIE subunit alpha
type: ProteinReference
xref: uniprot Q9P3W1 430
organism: Schizosaccharomyces pombe

uniprot Q20435 38
type: UnificationXref
id: Q20435
db: uniprot

uniprot O88828 285
type: UnificationXref
id: O88828
db: uniprot

PARTICIPANT STOICHIOMETRY r57 757
type: Stoichiometry
physical entity: s161
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 756
type: Stoichiometry
physical entity: TFIIE
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HU28 461
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r57 758
type: Stoichiometry
physical entity: s168
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 755
type: Stoichiometry
physical entity: Complex (TFIIF/RNA Polymerase II)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 754
type: Stoichiometry
physical entity: TFIIH complex
stoichiometric coefficient: 1.0

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 84

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 35

Polymerase (RNA) II (DNA directed) polypeptide L
type: ProteinReference
xref: uniprot A5D6S6 243
organism: Danio rerio

uniprot K7D0H2 392
type: UnificationXref
id: K7D0H2
db: uniprot

TBP associated factors s6 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP-associated factors
stoichiometric coefficient: 1.0

uniprot Q7QG89 490
type: UnificationXref
id: Q7QG89
db: uniprot

s170
type: Complex
component stoichiometry: Complex TBP associated factors TBP s100 a215 STOICHIOMETRY ID COMPLEX
component stoichiometry: TATA box Promoter gene s172 a218 STOICHIOMETRY ID COMPLEX
component stoichiometry: CRE s105 a284 STOICHIOMETRY ID COMPLEX
component stoichiometry: RNA Polymerase II s171 a217 STOICHIOMETRY ID COMPLEX
component: RNA Polymerase II
component: TATA box Promoter gene
component: CRE
component: Complex (TBP-associated factors/TBP)
feature: COMPLEX BINDING FEATURE s170 csa27 708
feature: COMPLEX BINDING FEATURE s170 csa27 706
feature: COMPLEX BINDING FEATURE s170 csa27 702
feature: COMPLEX BINDING FEATURE s170 csa27 704

Uncharacterized protein
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot A0A3Q2TVW3 242
organism: Gallus gallus

CRE s157 a256 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRE
stoichiometric coefficient: 1.0

uniprot Q9N5K2 327
type: UnificationXref
id: Q9N5K2
db: uniprot

uniprot Q92759 407
type: UnificationXref
id: Q92759
db: uniprot

Complex (TFIIF/RNA Polymerase II)
type: Complex
component stoichiometry: TFIIF s7 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: RNA Polymerase II s8 sa23 STOICHIOMETRY ID COMPLEX
component: TFIIF
component: RNA Polymerase II
feature: COMPLEX BINDING FEATURE s60 a148 690
feature: COMPLEX BINDING FEATURE s60 a148 688

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GSG6 148
organism: Macaca mulatta

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 113

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: uniprot P36145 222
xref: PTHR12716:SF8
organism: Saccharomyces cerevisiae

uniprot Q62880 186
type: UnificationXref
id: Q62880
db: uniprot

TATA box-binding protein-like protein 2
type: ProteinReference
xref: uniprot A6H907 510
xref: PTHR10126:SF37
organism: Pan troglodytes

uniprot Q66HA2 43
type: UnificationXref
id: Q66HA2
db: uniprot

PTHR47227:SF1
type: RelationshipXref
id: PTHR47227:SF1
db: PANTHER Family
relationship type: By Homology

General transcription factor IIH subunit 1
type: ProteinReference
xref: uniprot E2RCX0 388
organism: Canis lupus familiaris

uniprot F4NX01 454
type: UnificationXref
id: F4NX01
db: uniprot

TBP
type: Protein
entity reference: TBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa14 673
comment: SPECIES_TYPE=PROTEIN

RNA Polymerase II
type: Protein
entity reference: RNA Polymerase II
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s180 a122 699
feature: RNA Polymerase II s180 a122 rs2
feature: RNA Polymerase II s180 a122 rs1
feature: RNA Polymerase II s180 a122 rs4
feature: RNA Polymerase II s180 a122 rs3
comment: SPECIES_TYPE=PROTEIN

uniprot Q5U385 543
type: UnificationXref
id: Q5U385
db: uniprot

uniprot Q6P1X5 190
type: UnificationXref
id: Q6P1X5
db: uniprot

uniprot Q9M1H8 325
type: UnificationXref
id: Q9M1H8
db: uniprot

uniprot Q9HAW0 499
type: UnificationXref
id: Q9HAW0
db: uniprot

TATA box Promoter s25 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TATA box Promoter
stoichiometric coefficient: 1.0

DNA-directed RNA polymerase subunit 5-like protein 1
type: ProteinReference
xref: PTHR10535:SF15
xref: uniprot Q9FJL8 324
organism: Arabidopsis thaliana

TBP-associated factors
type: Protein
entity reference: TBP-associated factors
feature: COMPLEX PARTICIPANT BINDING FEATURE s187 sa10 591
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 60STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 18

PARTICIPANT STOICHIOMETRY r86 761
type: Stoichiometry
physical entity: Complex (CBP/P300/ CREB)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r86 762
type: Stoichiometry
physical entity: Complex (TBP/TBP-associated factors)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r86 763
type: Stoichiometry
physical entity: TFIIA complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r86 764
type: Stoichiometry
physical entity: Complex (CRE/TATA box Promoter)
stoichiometric coefficient: 1.0

Complex (CREB/CBP/ P300)
type: Complex
component stoichiometry: HOMODIMER ID 59STOICHIOMETRY ID COMPLEX
component stoichiometry: CBP P300 s54 sa36 STOICHIOMETRY ID COMPLEX
component stoichiometry: CRE s166 a259 STOICHIOMETRY ID COMPLEX
component: CREB
component: CBP/P300
component: CRE
feature: COMPLEX BINDING FEATURE s113 a266 622
feature: COMPLEX BINDING FEATURE s113 a266 624
feature: COMPLEX PARTICIPANT BINDING FEATURE s113 a266 629
feature: COMPLEX BINDING FEATURE s113 a266 626

PARTICIPANT STOICHIOMETRY r86 765
type: Stoichiometry
physical entity: s160
stoichiometric coefficient: 1.0

TFIIB
type: Protein
entity reference: TFIIB
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa29 641
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r36 715
type: Stoichiometry
physical entity: TBP-associated factors
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r84
controller: Complex (Receptor/hormone)

General transcription factor IIA subunit 1
type: ProteinReference
xref: uniprot F6QGV9 348
xref: PTHR12694:SF7
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r36 716
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot Q568H8 308
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r36 717
type: Stoichiometry
physical entity: Complex (TBP/TBP-associated factors)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E9G2Q6 260
organism: Daphnia pulex

BRF1, RNA polymerase III transcription initiation factor subunit
type: ProteinReference
xref: uniprot H2Q908 463
organism: Pan troglodytes

uniprot A0A0G2JWQ0 385
type: UnificationXref
id: A0A0G2JWQ0
db: uniprot

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
type: ProteinReference
xref: uniprot H2QSV3 153
organism: Pan troglodytes

RCG43696, isoform CRA_b
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot D3ZY89 129
organism: Rattus norvegicus

uniprot Q8CFK2 492
type: UnificationXref
id: Q8CFK2
db: uniprot

TATA box Promoter gene
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s172 a218 707
comment: SPECIES_TYPE=GENE

Transcription initiation factor IIA subunit 2-2
type: ProteinReference
xref: uniprot Q9W5B9 377
organism: Drosophila melanogaster

uniprot Q8W0W3 495
type: UnificationXref
id: Q8W0W3
db: uniprot

Cyclic AMP-responsive element-binding protein 3-like protein 1
type: ProteinReference
xref: PTHR46004:SF1
xref: uniprot Q9Z125 56
organism: Mus musculus

uniprot Q6DEG5 310
type: UnificationXref
id: Q6DEG5
db: uniprot

uniprot F1MUX7 219
type: UnificationXref
id: F1MUX7
db: uniprot

uniprot F6VRF4 270
type: UnificationXref
id: F6VRF4
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P30625 92
organism: Caenorhabditis elegans

Complex TBP associated factors TBP TATA box Promoter TFIIA complex s55 a141 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (TBP-associated factors/TBP/ TATA box Promoter/TFIIA complex)
stoichiometric coefficient: 1.0

Transcription initiation factor IIE subunit beta
type: ProteinReference
xref: uniprot P79011 223
xref: PTHR12716:SF8
organism: Schizosaccharomyces pombe

TFIIFbeta
type: Protein
entity reference: TFIIFbeta
comment: SPECIES_TYPE=PROTEIN

Transcription factor IIIB 50 kDa subunit
type: ProteinReference
xref: uniprot F7EEK0 459
organism: Macaca mulatta

TBP associated factors s178 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP-associated factors
stoichiometric coefficient: 1.0

ncbitaxon 9544 20
type: UnificationXref
id: 9544
db: ncbitaxon

TATA box Promoter s17 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TATA box Promoter
stoichiometric coefficient: 1.0

uniprot A0A2I3SS53 386
type: UnificationXref
id: A0A2I3SS53
db: uniprot

Cyclic AMP-responsive element-binding protein 3-like protein 3
type: ProteinReference
xref: PTHR45996:SF1
xref: uniprot Q91XE9 52
organism: Mus musculus

DNA-directed RNA polymerases I, II, and III subunit RPABC2
type: ProteinReference
xref: PTHR10773:SF12
xref: uniprot Q24320 302
organism: Drosophila melanogaster

uniprot O97183 287
type: UnificationXref
id: O97183
db: uniprot

uniprot Q5ZHP3 485
type: UnificationXref
id: Q5ZHP3
db: uniprot

uniprot P61219 295
type: UnificationXref
id: P61219
db: uniprot

Polymerase (RNA) II (DNA directed) polypeptide F
type: ProteinReference
xref: PTHR10773:SF12
xref: uniprot Q6DDA6 309
organism: Xenopus tropicalis

Transcription initiation factor TFIID subunit 2
type: ProteinReference
xref: uniprot Q24325 175
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GMZ1 451
organism: Daphnia pulex

uniprot E2RGQ0 432
type: UnificationXref
id: E2RGQ0
db: uniprot

uniprot Q9P5N7 409
type: UnificationXref
id: Q9P5N7
db: uniprot

uniprot A0A1D5Q6K1 240
type: UnificationXref
id: A0A1D5Q6K1
db: uniprot

Transcription termination factor 1
type: ProteinReference
xref: uniprot Q62187 339
organism: Mus musculus

Receptor
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q5ZM91 111
organism: Gallus gallus

cAMP-responsive element modulator
type: ProteinReference
xref: uniprot P27699 32
organism: Mus musculus

uniprot F7GF94 276
type: UnificationXref
id: F7GF94
db: uniprot

Cyclic AMP-responsive element-binding protein 3-like protein 4
type: ProteinReference
xref: PTHR45996:SF2
xref: uniprot Q5UEM7 41
organism: Rattus norvegicus

Transcription initiation factor TFIID subunit 9
type: ProteinReference
xref: uniprot Q9SYH2 211
organism: Arabidopsis thaliana

ncbitaxon 9606 37
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot F6SFX7 140
type: UnificationXref
id: F6SFX7
db: uniprot

PTHR10445:SF0
type: RelationshipXref
id: PTHR10445:SF0
db: PANTHER Family
relationship type: By Homology

uniprot Q9SYZ9 212
type: UnificationXref
id: Q9SYZ9
db: uniprot

CRE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s105 a284 709
comment: SPECIES_TYPE=GENE

uniprot A6H914 511
type: UnificationXref
id: A6H914
db: uniprot

Transcription factor IIB
type: ProteinReference
xref: uniprot F7BVN4 458
organism: Macaca mulatta

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot P62915 475
organism: Mus musculus

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot P62916 476
organism: Rattus norvegicus

uniprot Q7Q8X9 192
type: UnificationXref
id: Q7Q8X9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot B3RID1 247
organism: Trichoplax adhaerens

Bos taurus
type: BioSource
xref: ncbitaxon 9913 9

Adenylate kinase isoenzyme 6 isoform a
type: ProteinReference
xref: uniprot F7E5B3 144
organism: Macaca mulatta

uniprot P17871 530
type: UnificationXref
id: P17871
db: uniprot

PSMC3 interacting protein
type: ProteinReference
xref: uniprot H2QD27 526
organism: Pan troglodytes

STATE_TRANSITION_LEFT__ATP-_s168-RIGHT__TFIIE-_s169-_ADP-_r58
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 751
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 752
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 753
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 749
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 750
left: ATP
left: s168
interaction type: STATE_TRANSITION
right: s169
right: TFIIE
right: ADP

DNA-directed RNA polymerase
type: ProteinReference
xref: uniprot B7Q8S0 249
organism: Ixodes scapularis

uniprot A0A3Q1MJS5 8
type: UnificationXref
id: A0A3Q1MJS5
db: uniprot

RNA Polymerase II
type: ProteinReference
xref: P01388
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.RNA Polymerase II
comment: ENTITY_REFERENCE_NOTES= Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P01388
member entity reference: DNA-directed RNA polymerases I, II, and III subunit RPABC1
member entity reference: RNA polymerase II subunit E
member entity reference: POLR2C isoform 1
member entity reference: Uncharacterized protein
member entity reference: DNA-directed RNA polymerases I, II, and III subunit RPABC3
member entity reference: DNA-directed RNA polymerases II, IV and V subunit 3
member entity reference: DNA-directed RNA polymerase II subunit rpb4
member entity reference: DNA-directed RNA polymerase
member entity reference: DNA-directed RNA polymerase II polypeptide
member entity reference: DNA-directed RNA polymerase subunit 5-like protein 1
member entity reference: DNA-directed RNA polymerase II subunit 4
member entity reference: DNA-directed RNA polymerases I, II, and III subunit RPABC2
member entity reference: Polymerase (RNA) II (DNA directed) polypeptide F
member entity reference: DNA-directed RNA polymerases I, II, and III subunit RPABC5
member entity reference: DNA-directed RNA polymerase II subunit RPB3
member entity reference: Polymerase (RNA) II (DNA directed) polypeptide L
member entity reference: DNA-directed RNA polymerases II, IV and V subunit 9B
member entity reference: DNA binding / DNA-directed RNA polymerase
member entity reference: AGAP010321-PA
member entity reference: DNA-directed RNA polymerase V subunit 5A
member entity reference: POLR2F isoform 2
member entity reference: RNA polymerase II subunit C
member entity reference: RE34924p
member entity reference: RNA polymerase II subunit F
member entity reference: DNA-directed RNA polymerases IV and V subunit 5B
member entity reference: AGAP011761-PA
member entity reference: Predicted protein
member entity reference: RNA polymerase common subunit RPB6
member entity reference: DNA-directed RNA polymerase II 16 kDa subunit,putative
member entity reference: POLR2E isoform 1
member entity reference: Polymerase (RNA) II (DNA directed) polypeptide E
member entity reference: AGAP010064-PA
member entity reference: DNA-directed RNA polymerase V subunit 5C
member entity reference: GH07456p
member entity reference: Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3
member entity reference: MGC146599 protein
member entity reference: DNA-directed RNA polymerases II, IV and V subunit 9A

uniprot Q9MAU3 207
type: UnificationXref
id: Q9MAU3
db: uniprot

uniprot O96880 420
type: UnificationXref
id: O96880
db: uniprot

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot Q7Q0D5 315
organism: Anopheles gambiae

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31324 95
xref: PTHR11635:SF156
organism: Mus musculus

uniprot F6UVN1 522
type: UnificationXref
id: F6UVN1
db: uniprot

E1A binding protein p300
type: ProteinReference
xref: uniprot H2QLS0 232
xref: PTHR13808:SF29
organism: Pan troglodytes

uniprot F7BVJ4 390
type: UnificationXref
id: F7BVJ4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FZ67 146
organism: Monodelphis domestica

uniprot Q7YTH5 194
type: UnificationXref
id: Q7YTH5
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 250

uniprot Q7PPI8 114
type: UnificationXref
id: Q7PPI8
db: uniprot

Transcription factor IIIB 90 kDa subunit
type: ProteinReference
xref: uniprot Q8CFK2 492
organism: Mus musculus

RNA polymerase II subunit E
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot F6X571 271
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r87 760
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

uniprot O96150 286
type: UnificationXref
id: O96150
db: uniprot

ncbitaxon 214684 110
type: UnificationXref
id: 214684
db: ncbitaxon

Spermatocyte arrest
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q9VP40 215
organism: Drosophila melanogaster

uniprot Q9YGV8 555
type: UnificationXref
id: Q9YGV8
db: uniprot

TFIIEbeta
type: Protein
entity reference: TFIIEbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa5 693
comment: SPECIES_TYPE=PROTEIN

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot Q58192 482
organism: Methanocaldococcus jannaschii

uniprot H2QD27 526
type: UnificationXref
id: H2QD27
db: uniprot

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F1MD32 227
organism: Bos taurus

TFIIF s50 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIF
stoichiometric coefficient: 1.0

uniprot H2QB71 278
type: UnificationXref
id: H2QB71
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31323 94
xref: PTHR11635:SF156
organism: Homo sapiens

uniprot P16905 91
type: UnificationXref
id: P16905
db: uniprot

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: uniprot P31321 93
xref: PTHR11635:SF126
organism: Homo sapiens

uniprot Q5ZM91 111
type: UnificationXref
id: Q5ZM91
db: uniprot

PARTICIPANT STOICHIOMETRY r87 759
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 65

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P12369 88
organism: Rattus norvegicus

uniprot P41900 439
type: UnificationXref
id: P41900
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12367 86
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12368 87
organism: Rattus norvegicus

TFIIA complex
type: Protein
entity reference: TFIIA complex
comment: SPECIES_TYPE=PROTEIN

CREB
type: Protein
entity reference: CREB
feature: ACTIVE 57
feature: CREB s101 a224 rs1
comment: SPECIES_TYPE=PROTEIN

Transcription initiation factor TFIID subunit 2
type: ProteinReference
xref: uniprot Q8C176 196
organism: Mus musculus

uniprot F1QEC8 68
type: UnificationXref
id: F1QEC8
db: uniprot

TATA-box-binding protein 1
type: ProteinReference
xref: uniprot Q8TI26 551
xref: PTHR10126:SF42
organism: Methanosarcina acetivorans

uniprot O08950 353
type: UnificationXref
id: O08950
db: uniprot

uniprot P13861 90
type: UnificationXref
id: P13861
db: uniprot

uniprot Q5ZMS1 184
type: UnificationXref
id: Q5ZMS1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BVJ4 390
organism: Monodelphis domestica

CRE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s157 a256 681
comment: SPECIES_TYPE=GENE

uniprot B7Q0X0 447
type: UnificationXref
id: B7Q0X0
db: uniprot

TTF1 isoform 2
type: ProteinReference
xref: uniprot H2QY30 335
organism: Pan troglodytes

TFIIH complex
type: Protein
entity reference: TFIIH complex
comment: SPECIES_TYPE=PROTEIN

uniprot Q9UNN4 375
type: UnificationXref
id: Q9UNN4
db: uniprot

TATA box-binding protein-like protein 2
type: ProteinReference
xref: uniprot Q28DH2 541
xref: PTHR10126:SF37
organism: Xenopus tropicalis

TAF9B isoform 2
type: ProteinReference
xref: uniprot H2R4N5 154
organism: Pan troglodytes

uniprot Q9Z125 56
type: UnificationXref
id: Q9Z125
db: uniprot

Histone acetyltransferase p300
type: ProteinReference
xref: uniprot F6T7D0 230
xref: PTHR13808:SF29
organism: Macaca mulatta

PTHR10535:SF2
type: RelationshipXref
id: PTHR10535:SF2
db: PANTHER Family
relationship type: By Homology

PTHR13097:SF7
type: RelationshipXref
id: PTHR13097:SF7
db: PANTHER Family
relationship type: By Homology

uniprot F7CP70 414
type: UnificationXref
id: F7CP70
db: uniprot

PTHR10535:SF0
type: RelationshipXref
id: PTHR10535:SF0
db: PANTHER Family
relationship type: By Homology

Cyclic AMP response element-binding protein B
type: ProteinReference
xref: PTHR45879:SF3
xref: uniprot Q9VWW0 55
organism: Drosophila melanogaster

CREB s158 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
type: ProteinReference
xref: uniprot H2R9Q1 155
organism: Pan troglodytes

cAMP-responsive element-binding protein 1
type: ProteinReference
xref: PTHR45879:SF1
xref: uniprot F6QA46 17
organism: Xenopus tropicalis

uniprot F7BVN4 458
type: UnificationXref
id: F7BVN4
db: uniprot

uniprot A0A3Q1MS65 124
type: UnificationXref
id: A0A3Q1MS65
db: uniprot

uniprot F6PUU3 15
type: UnificationXref
id: F6PUU3
db: uniprot

uniprot Q9NEX2 374
type: UnificationXref
id: Q9NEX2
db: uniprot

uniprot F6Q9S4 70
type: UnificationXref
id: F6Q9S4
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P49605 98
organism: Ustilago maydis

Histone acetyltransferase p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot B2RWS6 225
organism: Mus musculus

uniprot Q8LPF0 198
type: UnificationXref
id: Q8LPF0
db: uniprot

uniprot P26355 533
type: UnificationXref
id: P26355
db: uniprot

TATA box Promoter s71 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TATA box Promoter
stoichiometric coefficient: 1.0

uniprot Q6B857 486
type: UnificationXref
id: Q6B857
db: uniprot

uniprot F7CRN2 274
type: UnificationXref
id: F7CRN2
db: uniprot

uniprot Q01386 101
type: UnificationXref
id: Q01386
db: uniprot

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot Q8TT29 493
organism: Methanosarcina acetivorans

uniprot Q92994 498
type: UnificationXref
id: Q92994
db: uniprot

ncbitaxon 9031 65
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot Q1K7U9 424
type: UnificationXref
id: Q1K7U9
db: uniprot

AGAP010064-PA
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot Q7PJW8 313
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R6P6 343
organism: Macaca mulatta

Transcription initiation factor IIB 3
type: ProteinReference
xref: uniprot Q9HHK5 500
organism: Halobacterium salinarum

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q9P6 342
organism: Macaca mulatta

Transcription initiation factor TFIID subunit 11
type: ProteinReference
xref: uniprot Q99JX1 202
organism: Mus musculus

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 200

uniprot Q9FJL8 324
type: UnificationXref
id: Q9FJL8
db: uniprot

Complex CREB CBP P300 s162 a267 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (CREB/CBP/ P300)
stoichiometric coefficient: 1.0

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q9VWY6 216
organism: Drosophila melanogaster

PKA
type: Protein
entity reference: PKA
feature: PKA s107 a307 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot Q8ZWS3 496
type: UnificationXref
id: Q8ZWS3
db: uniprot

TBP s24 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

uniprot Q4QF64 106
type: UnificationXref
id: Q4QF64
db: uniprot

uniprot P62340 537
type: UnificationXref
id: P62340
db: uniprot

uniprot H2QVG0 28
type: UnificationXref
id: H2QVG0
db: uniprot

Transcription initiation factor TFIID subunit 11
type: ProteinReference
xref: uniprot Q5U1X0 182
organism: Rattus norvegicus

P01389
type: UnificationXref
id: P01389
db: PANTHER Pathway Component

P01388
type: UnificationXref
id: P01388
db: PANTHER Pathway Component

P01387
type: UnificationXref
id: P01387
db: PANTHER Pathway Component

P01386
type: UnificationXref
id: P01386
db: PANTHER Pathway Component

P01385
type: UnificationXref
id: P01385
db: PANTHER Pathway Component

uniprot Q24325 175
type: UnificationXref
id: Q24325
db: uniprot

P01384
type: UnificationXref
id: P01384
db: PANTHER Pathway Component

Complex (CREB/CBP/ P300)
type: Complex
component stoichiometry: CBP P300 s159 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: CRE s157 a256 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 62STOICHIOMETRY ID COMPLEX
component: CREB
component: CBP/P300
component: CRE
feature: COMPLEX BINDING FEATURE s156 a268 684
feature: COMPLEX BINDING FEATURE s156 a268 680
feature: COMPLEX BINDING FEATURE s156 a268 682
feature: COMPLEX PARTICIPANT BINDING FEATURE s156 a268 687

P01383
type: UnificationXref
id: P01383
db: PANTHER Pathway Component

uniprot A0A1D5R6P6 343
type: UnificationXref
id: A0A1D5R6P6
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot H2RER5 75
xref: PTHR11635:SF156
organism: Pan troglodytes

At1g07470/F22G5_13
type: ProteinReference
xref: PTHR12694:SF8
xref: uniprot Q93VP4 370
organism: Arabidopsis thaliana

TATA box Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa15 675
comment: SPECIES_TYPE=GENE

uniprot Q68CJ9 44
type: UnificationXref
id: Q68CJ9
db: uniprot

uniprot E2RCC0 519
type: UnificationXref
id: E2RCC0
db: uniprot

P01398
type: UnificationXref
id: P01398
db: PANTHER Pathway Component

P01397
type: UnificationXref
id: P01397
db: PANTHER Pathway Component

P01399
type: UnificationXref
id: P01399
db: PANTHER Pathway Component

P01394
type: UnificationXref
id: P01394
db: PANTHER Pathway Component

P01396
type: UnificationXref
id: P01396
db: PANTHER Pathway Component

P01395
type: UnificationXref
id: P01395
db: PANTHER Pathway Component

CREB
type: Protein
entity reference: CREB
feature: ACTIVE 57
feature: CREB s154 sa50 rs1

P01390
type: UnificationXref
id: P01390
db: PANTHER Pathway Component

P01392
type: UnificationXref
id: P01392
db: PANTHER Pathway Component

uniprot Q5UEM7 41
type: UnificationXref
id: Q5UEM7
db: uniprot

P01391
type: UnificationXref
id: P01391
db: PANTHER Pathway Component

CREB s103 a237 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: uniprot Q7SEH7 366
xref: PTHR10966:SF0
organism: Neurospora crassa

uniprot Q9HBM6 205
type: UnificationXref
id: Q9HBM6
db: uniprot

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 248

Cyclic AMP-responsive element-binding protein 3-like protein 2
type: ProteinReference
xref: PTHR46004:SF2
xref: uniprot Q6QDP7 45
organism: Rattus norvegicus

uniprot B0BN78 128
type: UnificationXref
id: B0BN78
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Receptor-_hormone-RIGHT__Complex__Receptor_hormone_-_r83
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 714
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 713
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 712
left: hormone
left: Receptor
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Receptor/hormone)

TBP
type: ProteinReference
xref: P01399
standard name: Tata binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: TBP Synonym: GTF2D,GTF2D1,SCA17,TATA box binding protein,TFIID,spinocerebellar ataxia 17 Accession: P01399
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TBP
member entity reference: TATA box-binding protein-like protein 2
member entity reference: TATA-box-binding protein 3
member entity reference: Uncharacterized protein
member entity reference: TATA box-binding protein-like protein 1
member entity reference: TATA-box-binding protein 2
member entity reference: TATA-box-binding protein
member entity reference: Homologous-pairing protein 2 homolog
member entity reference: AGAP010958-PA
member entity reference: TATA box binding protein, isoform CRA_a
member entity reference: TATA-box-binding protein 1
member entity reference: TBP-related factor
member entity reference: TATA-box binding protein
member entity reference: TATA-binding protein
member entity reference: PSMC3 interacting protein
member entity reference: TBP-Like Factor
member entity reference: Protein CBR-TBP-1
member entity reference: TATA-box-binding protein-like 1
member entity reference: TATA-box binding protein like 1

TATA-box binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot F1PQA5 520
organism: Canis lupus familiaris

uniprot A0A2R8PXU1 217
type: UnificationXref
id: A0A2R8PXU1
db: uniprot

Transcription initiation factor TFIID subunit 6b
type: ProteinReference
xref: uniprot F4HVA6 137
organism: Arabidopsis thaliana

ncbitaxon 5664 107
type: UnificationXref
id: 5664
db: ncbitaxon

PTHR45996:SF5
type: RelationshipXref
id: PTHR45996:SF5
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot A0A1D5Q6K1 240
organism: Macaca mulatta

PTHR45996:SF4
type: RelationshipXref
id: PTHR45996:SF4
db: PANTHER Family
relationship type: By Homology

PTHR45996:SF1
type: RelationshipXref
id: PTHR45996:SF1
db: PANTHER Family
relationship type: By Homology

PTHR45996:SF2
type: RelationshipXref
id: PTHR45996:SF2
db: PANTHER Family
relationship type: By Homology

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot O13270 528
organism: Gallus gallus

uniprot Q27896 540
type: UnificationXref
id: Q27896
db: uniprot

RNA Polymerase II s48 sa30 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PCI4 64
xref: PTHR11635:SF126
organism: Gallus gallus

ncbitaxon 10228 248
type: UnificationXref
id: 10228
db: ncbitaxon

Transcription initiation factor TFIID subunit 9
type: ProteinReference
xref: uniprot Q16594 173
organism: Homo sapiens

BRF (Transcription factor) homolog
type: ProteinReference
xref: uniprot A0A131MCT5 444
organism: Caenorhabditis elegans

PTHR48014:SF24
type: RelationshipXref
id: PTHR48014:SF24
db: PANTHER Family
relationship type: By Homology

TATA-box-binding protein-associated factor 12
type: ProteinReference
xref: uniprot B0BLT7 127
organism: Xenopus tropicalis

PKA
type: ProteinReference
xref: P01384
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein Kinase A Synonym: protein kinase A Accession: P01384
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.PKA
member entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
member entity reference: cAMP-dependent protein kinase type I regulatory subunit
member entity reference: Prkar1a protein
member entity reference: cAMP-dependent protein kinase regulatory subunit
member entity reference: Protein kinase A regulatory subunit
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: Uncharacterized protein
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: Protein kinase cAMP-dependent type I regulatory subunit alpha
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: PRKAR2A isoform 1
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, beta
member entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit
member entity reference: AGAP004940-PA
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha
member entity reference: PRKAR1A isoform 12

Complex (Receptor/hormone)
type: Complex
component stoichiometry: Receptor s68 sa51 STOICHIOMETRY ID COMPLEX
component stoichiometry: hormone s69 sa52 STOICHIOMETRY ID COMPLEX
component: Receptor
component: hormone
feature: COMPLEX BINDING FEATURE s125 a299 618
feature: COMPLEX BINDING FEATURE s125 a299 620
cellular location: cytosol

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 97

uniprot Q7PFI3 548
type: UnificationXref
id: Q7PFI3
db: uniprot

ACTIVE 57
type: EntityFeature
comment: Active state

RNA polymerase common subunit RPB6
type: ProteinReference
xref: PTHR10773:SF12
xref: uniprot Q9PT88 328
organism: Gallus gallus

ncbitaxon 227321 78
type: UnificationXref
id: 227321
db: ncbitaxon

General transcription factor IIF subunit 1
type: ProteinReference
xref: PTHR13011:SF0
xref: uniprot Q3THK3 383
organism: Mus musculus

PTHR45879:SF1
type: RelationshipXref
id: PTHR45879:SF1
db: PANTHER Family
relationship type: By Homology

Transcription initiation factor IIA large subunit
type: ProteinReference
xref: uniprot P32773 355
xref: PTHR12694:SF8
organism: Saccharomyces cerevisiae

PTHR45879:SF3
type: RelationshipXref
id: PTHR45879:SF3
db: PANTHER Family
relationship type: By Homology

Transcription initiation factor IIA subunit 2
type: ProteinReference
xref: uniprot P32774 356
organism: Saccharomyces cerevisiae

Batrachochytrium dendrobatidis
type: BioSource
xref: ncbitaxon 684364 455

Transcription initiation factor TFIID subunit 9B
type: ProteinReference
xref: uniprot Q6NZA9 188
organism: Mus musculus

TFIIA complex
type: ProteinReference
xref: P01390
standard name: Transcription factor IIA
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: TFIIA Synonym: ALF,GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNITS,GTF2A1-like factor,MGC26254,TFIIA large subunit isoform ALF,TFIIA-alpha/beta-like factor Accession: P01390
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TFIIA complex
member entity reference: Transcription initiation factor IIA subunit 2
member entity reference: General transcription factor IIA subunit 1
member entity reference: Transcription initiation factor IIA large subunit
member entity reference: Transcription initiation factor IIA subunit 1
member entity reference: Uncharacterized protein
member entity reference: Transcription initiation factor IIA subunit 2-2
member entity reference: TFIIA-alpha and beta-like factor
member entity reference: TFIIA-L3
member entity reference: At1g07470/F22G5_13
member entity reference: General transcription factor 2A subunit 1-like
member entity reference: Transcription initiation factor IIA small chain homolog
member entity reference: General transcription facter IIA subunit 1 variant 1

ncbitaxon 178306 497
type: UnificationXref
id: 178306
db: ncbitaxon

HOMODIMER ID 62STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

ncbitaxon 284812 97
type: UnificationXref
id: 284812
db: ncbitaxon

CBP P300 s165 sa38 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.11
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

STATE_TRANSITION_LEFT__s160-_TFIIB-RIGHT__s161-_r54
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 774
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 772
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 773
left: s160
left: TFIIB
interaction type: STATE_TRANSITION
right: s161

uniprot P29052 468
type: UnificationXref
id: P29052
db: uniprot

AGAP009558-PA
type: ProteinReference
xref: uniprot Q7QG89 490
organism: Anopheles gambiae

TFIIB
type: ProteinReference
xref: P01397
standard name: Transcription factor IIB
comment: ENTITY_REFERENCE_NOTES= Long Name: TFIIB Synonym: GTF2B,RNA polymerase II transcription factor IIB,TF2B,general transcription factor IIB Accession: P01397
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TFIIB
member entity reference: Cilia and flagella associated protein 20
member entity reference: Transcription initiation factor IIB
member entity reference: BRF (Transcription factor) homolog
member entity reference: Transcription factor IIIB 50 kDa subunit
member entity reference: Uncharacterized protein
member entity reference: Predicted protein
member entity reference: Transcription initiation factor IIB-2
member entity reference: Transcription factor IIIB 60 kDa subunit
member entity reference: Transcription factor IIIB 70 kDa subunit
member entity reference: Cilia- and flagella-associated protein 20
member entity reference: AGAP009680-PA
member entity reference: Cyclin family protein
member entity reference: AGAP009558-PA
member entity reference: Cyclin/Brf1-like TBP-binding protein
member entity reference: CFAP20 isoform 1
member entity reference: Transcription initiation factor IIB 4
member entity reference: Plant-specific TFIIB-related protein 2
member entity reference: Transcription factor IIB
member entity reference: General transcription factor IIB
member entity reference: Transcription initiation factor IIB 6
member entity reference: General transcription factor 2B
member entity reference: Transcription initiation factor IIB 1
member entity reference: Transcription initiation factor IIB 3
member entity reference: Transcription initiation factor IIB 2
member entity reference: Transcription initiation factor IIB-1
member entity reference: AGAP004233-PA
member entity reference: BRF2 isoform 1
member entity reference: BRF1, RNA polymerase III transcription initiation factor subunit
member entity reference: Transcription factor IIIB 90 kDa subunit

uniprot O00268 157
type: UnificationXref
id: O00268
db: uniprot

mRNA
type: RnaRegion
comment: SPECIES_TYPE=RNA

General transcription factor IIF subunit 2
type: ProteinReference
xref: uniprot Q2T9L9 441
organism: Bos taurus

General transcription factor IIA subunit 1
type: ProteinReference
xref: PTHR12694:SF7
xref: uniprot F1MII0 347
organism: Bos taurus

uniprot P48512 472
type: UnificationXref
id: P48512
db: uniprot

uniprot Q9VNZ3 330
type: UnificationXref
id: Q9VNZ3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZB94 448
organism: Branchiostoma floridae

RNA polymerase II subunit E
type: ProteinReference
xref: uniprot F2Z4J4 265
organism: Bos taurus

General transcription factor IIF subunit 1
type: ProteinReference
xref: PTHR13011:SF0
xref: uniprot Q5EA53 384
organism: Bos taurus

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

General transcription factor IIH subunit 1
type: ProteinReference
xref: uniprot P32780 394
organism: Homo sapiens

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot F2Z4J6 452
organism: Bos taurus

uniprot F7HPQ7 149
type: UnificationXref
id: F7HPQ7
db: uniprot

uniprot Q0DLD3 360
type: UnificationXref
id: Q0DLD3
db: uniprot

STATE_TRANSITION_LEFT__s173-_TTF2-RIGHT__s181-_r61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 733
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 734
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 732
left: TTF2
left: s173
interaction type: STATE_TRANSITION
right: s181

General transcription factor IIF subunit 2
type: ProteinReference
xref: uniprot P13984 437
organism: Homo sapiens

uniprot Q02930 36
type: UnificationXref
id: Q02930
db: uniprot

TFIIA complex
type: Protein
entity reference: TFIIA complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa16 677
comment: SPECIES_TYPE=PROTEIN

uniprot E2RCX0 388
type: UnificationXref
id: E2RCX0
db: uniprot

Transcription initiation factor IIB 1
type: ProteinReference
xref: uniprot Q5JGN1 484
organism: Thermococcus kodakaraensis

Uncharacterized protein
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot F7HAK5 73
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r58 750
type: Stoichiometry
physical entity: s168
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 753
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 752
type: Stoichiometry
physical entity: s169
stoichiometric coefficient: 1.0

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 120

PARTICIPANT STOICHIOMETRY r58 751
type: Stoichiometry
physical entity: TFIIE
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot O59922 77
organism: Emericella nidulans

RNA Polymerase II s57 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA Polymerase II
stoichiometric coefficient: 1.0

ncbitaxon 9615 14
type: UnificationXref
id: 9615
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r58 749
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BV97 254
xref: PTHR11800:SF2
organism: Gallus gallus

POLR2F isoform 2
type: ProteinReference
xref: uniprot A0A2I3R9X3 241
xref: PTHR10773:SF12
organism: Pan troglodytes

TBP-associated factors
type: ProteinReference
xref: P01385
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TBP-associated factors
comment: ENTITY_REFERENCE_NOTES= Long Name: TBP-associated factors Synonym: TATA box binding protein-associated factors Accession: P01385
member entity reference: TATA-box binding protein associated factor 2
member entity reference: Uncharacterized protein
member entity reference: Transcription initiation factor TFIID subunit 8
member entity reference: Transcription initiation factor TFIID subunit 9
member entity reference: Transcription initiation factor TFIID subunit 11
member entity reference: Transcription initiation factor TFIID subunit 12
member entity reference: Adenylate kinase isoenzyme 6 isoform a
member entity reference: TATA-box binding protein associated factor 9
member entity reference: Transcription initiation factor TFIID subunit 7
member entity reference: TATA-box binding protein associated factor 11
member entity reference: RCG43696, isoform CRA_b
member entity reference: Os01g0510800 protein
member entity reference: Transcription initiation factor TFIID subunit 6
member entity reference: TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
member entity reference: Transcription initiation factor TFIID subunit 9-like protein
member entity reference: Transcription initiation factor TFIID subunit 2
member entity reference: Transcription initiation factor TFIID subunit 9B
member entity reference: AGAP005731-PA (Fragment)
member entity reference: TATA-box binding protein associated factor 8
member entity reference: RCG49239
member entity reference: TAF9B isoform 2
member entity reference: TAF7 RNA polymerase II, TATA box-binding protein (TBP)-associated factor
member entity reference: TATA box-binding protein-associated factor RNA polymerase I subunit C
member entity reference: TAF (TBP-associated transcription factor) family
member entity reference: Transcription initiation factor TFIID subunit 4
member entity reference: TATA-box-binding protein-associated factor 12
member entity reference: Bromodomain transcription factor
member entity reference: TATA-box-binding protein-associated factor 2
member entity reference: At3g02160
member entity reference: TATA-box binding protein associated factor 12
member entity reference: AGAP003094-PA
member entity reference: Transcription initiation factor TFIID subunit 6b
member entity reference: TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
member entity reference: TAF1C isoform 5

General transcription factor IIH, polypeptide 1, 62kDa
type: ProteinReference
xref: uniprot Q2KJ73 402
organism: Bos taurus

uniprot Q3T0Q3 307
type: UnificationXref
id: Q3T0Q3
db: uniprot

ncbitaxon 185431 105
type: UnificationXref
id: 185431
db: ncbitaxon

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot K7DBC8 233
organism: Pan troglodytes

uniprot E2R3P2 412
type: UnificationXref
id: E2R3P2
db: uniprot

DNA-directed RNA polymerases I, II, and III subunit RPABC3
type: ProteinReference
xref: PTHR10917:SF0
xref: uniprot F2Z4H3 264
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re19 720
type: Stoichiometry
physical entity: s181
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 721
type: Stoichiometry
physical entity: mRNA
stoichiometric coefficient: 1.0

General transcription factor IIE, polypeptide 2, beta
type: ProteinReference
xref: PTHR12716:SF8
xref: uniprot A0A2R8PXU1 217
organism: Danio rerio

PTHR10126:SF37
type: RelationshipXref
id: PTHR10126:SF37
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re19 724
type: Stoichiometry
physical entity: Complex (TBP/TBP-associated factors)
stoichiometric coefficient: 1.0

uniprot Q9D0D5 429
type: UnificationXref
id: Q9D0D5
db: uniprot

uniprot F6RRA8 229
type: UnificationXref
id: F6RRA8
db: uniprot

PARTICIPANT STOICHIOMETRY re19 722
type: Stoichiometry
physical entity: RNA Polymerase II
stoichiometric coefficient: 1.0

uniprot Q00403 477
type: UnificationXref
id: Q00403
db: uniprot

PARTICIPANT STOICHIOMETRY re19 723
type: Stoichiometry
physical entity: TATA box Promoter gene termination
stoichiometric coefficient: 1.0

PANTHER Pathway P00055 1
type: UnificationXref
id: P00055
db: PANTHER Pathway

TFIIH complex s42 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFIIH complex
stoichiometric coefficient: 1.0

uniprot G5EG47 220
type: UnificationXref
id: G5EG47
db: uniprot

Complex (TBP-associated factors/TBP)
type: Complex
component stoichiometry: TBP s10 sa34 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBP associated factors s9 sa33 STOICHIOMETRY ID COMPLEX
component: TBP
component: TBP-associated factors
feature: COMPLEX BINDING FEATURE s100 a215 602
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 a215 703
feature: COMPLEX BINDING FEATURE s100 a215 604

PTHR10126:SF42
type: RelationshipXref
id: PTHR10126:SF42
db: PANTHER Family
relationship type: By Homology

uniprot P52653 536
type: UnificationXref
id: P52653
db: uniprot

PTHR10126:SF41
type: RelationshipXref
id: PTHR10126:SF41
db: PANTHER Family
relationship type: By Homology

DNA-directed RNA polymerase II polypeptide
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot Q7S8Z5 317
organism: Neurospora crassa

CREB s154 sa50 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

Similar to cAMP responsive element binding protein 5 (Predicted)
type: ProteinReference
xref: uniprot D3ZBH0 11
organism: Rattus norvegicus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 82

RNA Polymerase II s183 a127 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA Polymerase II
stoichiometric coefficient: 1.0

STATE TRANSITION LEFT s181-RIGHT mRNA- RNA Polymerase II- TATA box Promoter gene termination - Complex TBP TBP associated factors - re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 724
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 722
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 720
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 721
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 723
left: s181
display name: STATE_TRANSITION_LEFT__s181-RIGHT__mRNA-_RNA_Polymerase_II-_TATA_box_Promoter______________________________________________gene____________________________________termination_____-_Complex__TBP_TBP_associated_factors_-_re19
interaction type: STATE_TRANSITION
right: mRNA
right: RNA Polymerase II
right: TATA box Promoter gene termination
right: Complex (TBP/TBP-associated factors)

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P36600 96
organism: Schizosaccharomyces pombe

uniprot Q96BA8 53
type: UnificationXref
id: Q96BA8
db: uniprot

uniprot Q8TT29 493
type: UnificationXref
id: Q8TT29
db: uniprot

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 105

General transcription factor IIH subunit 4
type: ProteinReference
xref: uniprot F6Y6M6 389
organism: Macaca mulatta

Transcription initiation factor TFIID subunit 9-like protein
type: ProteinReference
xref: uniprot F6SFX7 140
organism: Macaca mulatta

uniprot Q62187 339
type: UnificationXref
id: Q62187
db: uniprot

Complex (TATA box Promoter/TBP/ TBP-associated factors/TFIIA complex/ TFIIH complex/TFIIB/ RNA Polymerase II/TFIIF/ TFIIE)
type: Complex
component stoichiometry: RNA Polymerase II s48 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIB s45 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIE s52 sa32 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIH complex s42 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIF s50 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: TFIIA complex s40 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBP s35 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: TATA box Promoter s33 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBP associated factors s39 sa26 STOICHIOMETRY ID COMPLEX
component: TFIIB
component: TFIIF
component: RNA Polymerase II
component: TFIIA complex
component: TFIIH complex
component: TBP
component: TBP-associated factors
component: TATA box Promoter
component: TFIIE
feature: COMPLEX BINDING FEATURE s77 a176 642
feature: COMPLEX BINDING FEATURE s77 a176 630
feature: COMPLEX BINDING FEATURE s77 a176 638
feature: COMPLEX BINDING FEATURE s77 a176 632
feature: COMPLEX BINDING FEATURE s77 a176 646
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 a176 649
feature: COMPLEX BINDING FEATURE s77 a176 644
feature: COMPLEX BINDING FEATURE s77 a176 634
feature: COMPLEX BINDING FEATURE s77 a176 636
feature: COMPLEX BINDING FEATURE s77 a176 640

PTHR11800:SF2
type: RelationshipXref
id: PTHR11800:SF2
db: PANTHER Family
relationship type: By Homology

uniprot E2RN76 134
type: UnificationXref
id: E2RN76
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 245

Transcription initiation factor TFIID subunit 12
type: ProteinReference
xref: uniprot Q8VE65 201
organism: Mus musculus

RNA polymerase II subunit C
type: ProteinReference
xref: PTHR11800:SF2
xref: uniprot E2RQ42 256
organism: Canis lupus familiaris

uniprot F6UTN8 143
type: UnificationXref
id: F6UTN8
db: uniprot

uniprot Q32LB1 542
type: UnificationXref
id: Q32LB1
db: uniprot

PTHR15319:SF1
type: RelationshipXref
id: PTHR15319:SF1
db: PANTHER Family
relationship type: By Homology

PTHR10126:SF20
type: RelationshipXref
id: PTHR10126:SF20
db: PANTHER Family
relationship type: By Homology

uniprot E9G252 258
type: UnificationXref
id: E9G252
db: uniprot

uniprot F7G0B2 147
type: UnificationXref
id: F7G0B2
db: uniprot

uniprot P36100 423
type: UnificationXref
id: P36100
db: uniprot

uniprot Q5U1X0 182
type: UnificationXref
id: Q5U1X0
db: uniprot

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q9EQH4 204
organism: Mus musculus

uniprot Q5BKE0 181
type: UnificationXref
id: Q5BKE0
db: uniprot

Transcription initiation factor TFIID subunit 12
type: ProteinReference
xref: uniprot Q16514 172
organism: Homo sapiens

Complex (TBP/TBP-associated factors)
type: Complex
component stoichiometry: TBP associated factors s6 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: TBP s5 sa1 STOICHIOMETRY ID COMPLEX
component: TBP-associated factors
component: TBP
feature: COMPLEX BINDING FEATURE s44 a106 612
feature: COMPLEX BINDING FEATURE s44 a106 610

PKA s107 a307 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=0.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q93ZW3 428
type: UnificationXref
id: Q93ZW3
db: uniprot

ncbitaxon 10116 12
type: UnificationXref
id: 10116
db: ncbitaxon

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: uniprot Q9SYZ9 212
xref: PTHR46338:SF1
organism: Arabidopsis thaliana

TBP-associated factors
type: Protein
entity reference: TBP-associated factors
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa13 671
comment: SPECIES_TYPE=PROTEIN

Transcription initiation factor IIB-1
type: ProteinReference
xref: uniprot P48512 472
organism: Arabidopsis thaliana

uniprot P81900 100
type: UnificationXref
id: P81900
db: uniprot

uniprot A0A131MCT5 444
type: UnificationXref
id: A0A131MCT5
db: uniprot

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot P45481 234
organism: Mus musculus

RNA Polymerase II s57 sa42 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

TFIIH complex
type: ProteinReference
xref: P01392
standard name: Transcription factor IIH
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: TFIIH Synonym: GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1,GTF2H 62-KD SUBUNIT,GTF2H1,TFIIH 62-KD SUBUNIT,TRANSCRIPTION FACTOR IIH 62-KD SUBUNIT Accession: P01392
comment: ENTITY_REFERENCE_ID_DESC=Transcription regulation by bZIP transcription factor.PROTEIN.GENERIC.TFIIH complex
member entity reference: General transcription factor IIH subunit 4
member entity reference: GTF2H3 isoform 1
member entity reference: Transcription factor TFIIH subunit Tfb4
member entity reference: General transcription factor IIH subunit 1
member entity reference: General transcription factor IIH subunit 3
member entity reference: General transcription factor IIH, polypeptide 1, 62kDa
member entity reference: General transcription and DNA repair factor IIH subunit tfb2
member entity reference: General transcription and DNA repair factor IIH subunit TFB4
member entity reference: General transcription and DNA repair factor IIH subunit tcf-29
member entity reference: General transcription and DNA repair factor IIH subunit TFB2
member entity reference: Uncharacterized protein

AGAP010493-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q8X9 192
organism: Anopheles gambiae

PTHR13808:SF30
type: RelationshipXref
id: PTHR13808:SF30
db: PANTHER Family
relationship type: By Homology

PTHR13808:SF34
type: RelationshipXref
id: PTHR13808:SF34
db: PANTHER Family
relationship type: By Homology

Histone acetyltransferase p300
type: ProteinReference
xref: uniprot Q09472 236
xref: PTHR13808:SF29
organism: Homo sapiens

uniprot P60027 395
type: UnificationXref
id: P60027
db: uniprot

RNA Polymerase II s48 sa30 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.05

Polymerase (RNA) II (DNA directed) polypeptide E
type: ProteinReference
xref: uniprot Q28HF5 304
organism: Xenopus tropicalis

uniprot H2QSV3 153
type: UnificationXref
id: H2QSV3
db: uniprot

elongating mRNA
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 a123 701
comment: SPECIES_TYPE=RNA

ncbitaxon 54126 280
type: UnificationXref
id: 54126
db: ncbitaxon

uniprot F6PMC9 456
type: UnificationXref
id: F6PMC9
db: uniprot

uniprot Q8SX87 50
type: UnificationXref
id: Q8SX87
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q9SYH2 211
type: UnificationXref
id: Q9SYH2
db: uniprot

DNA-directed RNA polymerases I, II, and III subunit RPABC2
type: ProteinReference
xref: uniprot F2Z4C9 263
xref: PTHR47227:SF1
organism: Bos taurus

uniprot Q641W8 363
type: UnificationXref
id: Q641W8
db: uniprot

uniprot F6QA46 17
type: UnificationXref
id: F6QA46
db: uniprot

TFIIB
type: Protein
entity reference: TFIIB
comment: SPECIES_TYPE=PROTEIN

RNA Polymerase II s57 sa42 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

uniprot Q9P376 410
type: UnificationXref
id: Q9P376
db: uniprot

CREB3L4 isoform 1
type: ProteinReference
xref: PTHR45996:SF2
xref: uniprot H2Q045 24
organism: Pan troglodytes

CBP/P300
type: Protein
entity reference: CBP/P300
feature: CBP P300 s165 sa38 rs1
feature: ACTIVE 57
feature: COMPLEX PARTICIPANT BINDING FEATURE s165 sa38 667
comment: SPECIES_TYPE=PROTEIN

RNA Polymerase II s48 sa30 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

uniprot P47825 162
type: UnificationXref
id: P47825
db: uniprot

PTHR13808:SF29
type: RelationshipXref
id: PTHR13808:SF29
db: PANTHER Family
relationship type: By Homology

CRE s163 a257 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRE
stoichiometric coefficient: 1.0

Predicted protein
type: ProteinReference
xref: uniprot A7SJZ7 446
organism: Nematostella vectensis

Transcription initiation factor IIB
type: ProteinReference
xref: uniprot Q00403 477
organism: Homo sapiens

PTHR46338:SF10
type: RelationshipXref
id: PTHR46338:SF10
db: PANTHER Family
relationship type: By Homology

Cyclic AMP-responsive element-binding protein 3-like protein 4
type: ProteinReference
xref: PTHR45996:SF2
xref: uniprot F6VJI3 19
organism: Macaca mulatta

uniprot Q4JFH9 39
type: UnificationXref
id: Q4JFH9
db: uniprot

RNA Polymerase II s57 sa42 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

AGAP003094-PA
type: ProteinReference
xref: uniprot Q7QBM3 193
organism: Anopheles gambiae

uniprot F1MME0 136
type: UnificationXref
id: F1MME0
db: uniprot

RNA Polymerase II s48 sa30 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.5

HETERODIMER_ASSOCIATION_LEFT__CREB-_CBP_P300-RIGHT__Complex__CBP_P300__CREB_-_r85
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 771
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 770
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 769
left: CBP/P300
left: CREB
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CBP/P300/ CREB)

uniprot F6X571 271
type: UnificationXref
id: F6X571
db: uniprot

uniprot Q9EQH4 204
type: UnificationXref
id: Q9EQH4
db: uniprot

uniprot Q3T174 179
type: UnificationXref
id: Q3T174
db: uniprot

uniprot K7DBC8 233
type: UnificationXref
id: K7DBC8
db: uniprot

PSMC3 interacting protein
type: ProteinReference
xref: uniprot E2RCC0 519
organism: Canis lupus familiaris

RNA Polymerase II s57 sa42 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.05

uniprot Q9ZVB9 331
type: UnificationXref
id: Q9ZVB9
db: uniprot

Transcription initiation factor TFIID subunit 4
type: ProteinReference
xref: PTHR15138:SF18
xref: uniprot O00268 157
organism: Homo sapiens

TAF (TBP-associated transcription factor) family
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q7YTH5 194
organism: Caenorhabditis elegans

s161
type: Complex
component stoichiometry: Complex CREB CBP P300 s162 a267 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex TBP associated factors TBP TATA box Promoter TFIIB TFIIA complex s59 a147 STOICHIOMETRY ID COMPLEX
component: Complex (TBP-associated factors/TBP/ TATA box Promoter/TFIIB/ TFIIA complex)
component: Complex (CREB/CBP/ P300)
feature: COMPLEX BINDING FEATURE s161 csa24 660
feature: COMPLEX BINDING FEATURE s161 csa24 668

PARTICIPANT STOICHIOMETRY r61 733
type: Stoichiometry
physical entity: TTF2
stoichiometric coefficient: 1.0

PTHR10126:SF54
type: RelationshipXref
id: PTHR10126:SF54
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r61 734
type: Stoichiometry
physical entity: s181
stoichiometric coefficient: 1.0

PTHR10126:SF55
type: RelationshipXref
id: PTHR10126:SF55
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10535:SF0
xref: uniprot E9G252 258
organism: Daphnia pulex

HOMODIMER ID 61STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r61 732
type: Stoichiometry
physical entity: s173
stoichiometric coefficient: 1.0

Transcription factor IIIB 50 kDa subunit
type: ProteinReference
xref: uniprot Q4V8D6 481
organism: Rattus norvegicus

DNA-directed RNA polymerase II subunit RPB3
type: ProteinReference
xref: PTHR11800:SF2
xref: uniprot P37382 292
organism: Schizosaccharomyces pombe

uniprot F7CLY1 273
type: UnificationXref
id: F7CLY1
db: uniprot

STATE_TRANSITION_LEFT__s169-RIGHT__TFIIH_complex-_s170-_TFIIA_complex-_TFIIB-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 744
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 747
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 745
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 748
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 746
left: s169
interaction type: STATE_TRANSITION
right: TFIIH complex
right: TFIIA complex
right: TFIIB
right: s170

uniprot H2R4N5 154
type: UnificationXref
id: H2R4N5
db: uniprot