Vascular endothelial growth factor receptor 2
RAF proto-oncogene serine/threonine-protein kinase
Phosphatidylinositol 3-kinase catalytic subunit type 3
Phosphoinositide-3-kinase regulatory subunit 1
Ras-related C3 botulinum toxin substrate 1
Vascular Endothelial Growth Factor Receptor-2
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.RECEPTOR.VEGFR-2
ENTITY_REFERENCE_NOTES= Long Name: Vascular Endothelial Growth Factor Receptor-2 Synonym: Flk-1,KDR,Kinase Insert Domain Receptor,Tyrosine Kinase Growth Factor Receptor Accession: P01403
Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Dual specificity mitogen-activated protein kinase kinase 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
MODEL_NOTES=Panther Pathway: P00056 This pathway represents the signal transduction cascade initiated afterthe vascaular endothelial growth factor (VEGF) binds to its receptor VEGFR-2. VEGF can also bind to VEGFR-1, but less is known about the pathway resulting from the activation of that receptor. Activation of VEGFR-2 results in the increased proliferation, survival and migration of blood endothelial cells required for angiogenesis. Medline=11741095 Medline=12778165 Medline=13678960 PMID: 11741095 PMID: 12778165 PMID: 13678960
Dual-specificity mitogen-activated protein kinase kinase 2
Raf homolog serine/threonine-protein kinase Raf
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
Phosphatidylinositol 3-kinase regulatory subunit gamma
Non-specific serine/threonine protein kinase
Mitogen-activated protein kinase-activated protein kinase 2
A-Raf proto-oncogene, serine/threonine kinase
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
Transforming growth factor beta-1-induced transcript 1 protein
ENTITY_REFERENCE_NOTES= Long Name: Heat-Shock Protein 27 Synonym: HSPB1 Accession: P01412
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.HSP27
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.MEK
ENTITY_REFERENCE_NOTES= Long Name: MAPK/ERK Kinase Synonym: MAP2K,MAPKK,MKK,Mitogen-Activated Protein Kinase Kinase,PRKMK,Protein Kinase, Mitogen-Activated, Kinase Accession: P01402
Phosphoinositide-3-kinase regulatory subunit 3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.p38MAPK
ENTITY_REFERENCE_NOTES= Long Name: p38 Mitogen-Activated Protein Kinase Synonym: CSAID-Binding Protein 1,CSBP1,Cytokine-Suppressive Anti-Inflammatory Drug-Binding Protein 1,MAPK14,MXI2,Mitogen-Activated Protein Kinase 14,RK,SAPK2A,Stress-Activated Protein Kinase 2A,p38,p38-Alpha Accession: P01423
ENTITY_REFERENCE_NOTES= Long Name: Focal Adhesion Kinase Synonym: Cytoplasmic Protein-Tyrosine Kinase ,FAK1,Focal Adhesion Kinase 1,PTK2 Accession: P01420
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.FAK
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.HIF-1
ENTITY_REFERENCE_NOTES= Long Name: Hypoxia-Inducible Factor 1 Synonym: MOP1,Member of PAS Superfamily 1 Accession: P01401
Ras-related C3 botulinum toxin substrate 2
Raf-1 proto-oncogene, serine/threonine kinase
Phosphatidylinositol 3-kinase regulatory subunit beta
Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Ras-related C3 botulinum toxin substrate
ENTITY_REFERENCE_NOTES= Long Name: Rho GTPase Synonym: CDC42,Cell Division Cycle 42 Accession: P01421
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Rac
Transforming growth factor beta 1 induced transcript 1
Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)
Phosphoinositide-3-kinase regulatory subunit 2
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.PI3K
ENTITY_REFERENCE_NOTES= Long Name: Phosphatidylinositol 3-Kinase Synonym: Synonym not specified Accession: P01413
B-Raf proto-oncogene, serine/threonine kinase
Heat shock protein family B (small) member 2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
Mitogen-activated protein kinase (Fragment)
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Mitogen-activated protein kinase-activated protein kinase 2 and 3
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.MAPKAPK2/3
ENTITY_REFERENCE_NOTES= Long Name: Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 and 3 Synonym: 3PK,MAPKAP KINASE 2/3,MAPKAP3 Accession: P01415
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
Dual specificity mitogen-activated protein kinase kinase 2
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Akt/PKB
ENTITY_REFERENCE_NOTES= Long Name: Thymoma Viral Proto-Oncogene Synonym: Oncogene Akt,PKB,Protein Kinase B,RAC Serine/Threonine Protein Kinase Accession: P01408
Phosphatidylinositol 3-kinase regulatory subunit alpha
ETS proto-oncogene 1, transcription factor
Ras-related C3 botulinum toxin substrate 3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Paxillin
ENTITY_REFERENCE_NOTES= Long Name: Paxillin Synonym: PXN Accession: P01418
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.VRAP
ENTITY_REFERENCE_NOTES= Long Name: VEGFR-Associated Protein Synonym: SH2 Domain Protein 2A,SH2D2A,T-Cell SH2 Domain-Containing Adaptor Protein,TSAD Accession: P01405
Mitogen-activated protein kinase kinase 1
Hypoxia inducible factor 1 subunit alpha
RAC-alpha serine/threonine-protein kinase
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Raf
ENTITY_REFERENCE_NOTES= Long Name: Raf Oncogene Synonym: CRAF,Oncogene MIL,Oncogene Raf1,Transforming Replication-Defective Murine Retrovirus 3611-MSV,v-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 Accession: P01417
v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1
ENTITY_REFERENCE_NOTES= Long Name: v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1 Synonym: Ets1 Oncogene Accession: P01419
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Ets
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
ENTITY_REFERENCE_NOTES= Long Name: Sphingosine Kinase Synonym: SPHK Accession: P01404
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.SPK
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Sck
ENTITY_REFERENCE_NOTES= Long Name: Shc-Like Protein Synonym: Shc Adaptor Homolog Accession: P01424
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Ras
ENTITY_REFERENCE_NOTES= Long Name: Ras Synonym: H-Ras,K-Ras,N-Ras,p21 Accession: P01411
MAP kinase-activated protein kinase mak-2
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Erk
ENTITY_REFERENCE_NOTES= Long Name: Extracellular Signal-Regulated Kinase Synonym: JNK-Activated Kinase1,JNKK1,MAP2K4,MAPK/ERK KINASE 4,MAPKK4,MEK4,MKK4,Mitogen-Activated Protein Kinase Kinase 4,PRKMK4,Protein Kinase, Mitogen-Activated, Kinase 4,SAPK/ERK Kinase 1,SEK1,SERK1 Accession: P01407
Vascular endothelial growth factor receptor kdr-like
Raf homolog serine/threonine-protein kinase
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Mitogen-activated protein kinase kinase 2
Phosphatidylinositol 3-kinase VPS34-like
ENTITY_REFERENCE_NOTES= Long Name: Caspase 9 Synonym: APAF3,Apoptotic Protease Activating Factor 3 Accession: P01410
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Caspase9
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.PLC-_gamma_
ENTITY_REFERENCE_NOTES= Long Name: Phospholipase C-gamma Synonym: PHOSPHOLIPASE C-148,PLC1,PLC148,PLCG1 Accession: P01414
Harvey rat sarcoma viral oncogene homolog
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.PKC
ENTITY_REFERENCE_NOTES= Long Name: Protein Kinase C Synonym: Synonym not specified Accession: P01425
ENTITY_REFERENCE_NOTES= Long Name: Vascular Endothelial Growth Factor Synonym: VEGF-A Accession: P01406
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.VEGF
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.eNOS
ENTITY_REFERENCE_NOTES= Long Name: endothelial nitric oxide synthase Synonym: NOS3,Nitric Oxide Synthase 3,eNOS Accession: P01422
Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.cPLA_sub_2_endsub
ENTITY_REFERENCE_NOTES= Long Name: Cytoplasmic Phospholipase A2 Synonym: CPLA2,PLA2 Accession: P01409