Vascular endothelial growth factor receptor 2
type: ProteinReference
xref: PTHR24416:SF45
xref: uniprot P35968 62
organism: Homo sapiens

Phospholipase A2
type: ProteinReference
evidence: Evidence 109
xref: uniprot H2Q0T0 116
xref: PTHR10728:SF13
organism: Pan troglodytes

uniprot F1PXS7 29
type: UnificationXref
id: F1PXS7
db: uniprot

PTHR24356:SF303
type: RelationshipXref
id: PTHR24356:SF303
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ATU3 180
organism: Monodelphis domestica

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 329
xref: uniprot P04049 341
xref: PTHR44329:SF22
organism: Homo sapiens

VEGFR-2
type: Protein
entity reference: VEGFR-2
feature: ACTIVE 24
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 539
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7H3B3 477
type: UnificationXref
id: F7H3B3
db: uniprot

uniprot F6Y1Z2 380
type: UnificationXref
id: F6Y1Z2
db: uniprot

uniprot F1A411 141
type: UnificationXref
id: F1A411
db: uniprot

SH2 domain-containing protein 2A
type: ProteinReference
evidence: Evidence 77
xref: PTHR14388:SF9
xref: uniprot Q9QXK9 78
organism: Mus musculus

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6SZ66 230
xref: PTHR10048:SF7
organism: Monodelphis domestica

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

uniprot F7HHY8 316
type: UnificationXref
id: F7HHY8
db: uniprot

MEK
type: Protein
entity reference: MEK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Focal adhesion kinase 1
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot P34152 394
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A452DI16 336
xref: PTHR44329:SF55
organism: Bos taurus

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QK16 354
organism: Macaca mulatta

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

uniprot P36506 40
type: UnificationXref
id: P36506
db: uniprot

uniprot Q54NW4 367
type: UnificationXref
id: Q54NW4
db: uniprot

Caspase-9
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot P55211 124
organism: Homo sapiens

uniprot Q503B6 165
type: UnificationXref
id: Q503B6
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F1Q2Q9 226
organism: Canis lupus familiaris

uniprot P20444 499
type: UnificationXref
id: P20444
db: uniprot

uniprot Q0VD16 46
type: UnificationXref
id: Q0VD16
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63001 411
organism: Mus musculus

uniprot Q8CIH5 309
type: UnificationXref
id: Q8CIH5
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63000 410
organism: Homo sapiens

uniprot P05128 489
type: UnificationXref
id: P05128
db: uniprot

VEGFR-2
type: ProteinReference
xref: P01403
standard name: Vascular Endothelial Growth Factor Receptor-2
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.RECEPTOR.VEGFR-2
comment: ENTITY_REFERENCE_NOTES= Long Name: Vascular Endothelial Growth Factor Receptor-2 Synonym: Flk-1,KDR,Kinase Insert Domain Receptor,Tyrosine Kinase Growth Factor Receptor Accession: P01403
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Kinase insert domain receptor
member entity reference: KDR isoform 1
member entity reference: Uncharacterized protein
member entity reference: Vascular endothelial growth factor receptor 2
member entity reference: Vascular endothelial growth factor receptor kdr-like

uniprot Q23130 416
type: UnificationXref
id: Q23130
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A8WR64 451
xref: PTHR24356:SF347
organism: Caenorhabditis briggsae

uniprot A0A3Q1N9F5 449
type: UnificationXref
id: A0A3Q1N9F5
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 23

uniprot Q94125 289
type: UnificationXref
id: Q94125
db: uniprot

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

Phospholipase A2
type: ProteinReference
evidence: Evidence 109
xref: PTHR10728:SF13
xref: uniprot F7CBU9 113
organism: Monodelphis domestica

Erk
type: Protein
entity reference: Erk
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P28482 93
xref: PTHR24055:SF203
organism: Homo sapiens

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot Q16644 322
organism: Homo sapiens

uniprot P49137 320
type: UnificationXref
id: P49137
db: uniprot

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 a32 537
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

Protein kinase C-like 3
type: ProteinReference
xref: uniprot Q19266 517
xref: PTHR24356:SF303
organism: Caenorhabditis elegans

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot P49071 319
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 29
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Ca2_PLUS_-_PKC-RIGHT__PKC_Ca2_PLUS_-_re30
controller: DAG

ncbitaxon 7955 53
type: UnificationXref
id: 7955
db: ncbitaxon

Rac
type: Protein
entity reference: Rac
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q19266 517
type: UnificationXref
id: Q19266
db: uniprot

uniprot F1MBU9 224
type: UnificationXref
id: F1MBU9
db: uniprot

uniprot P15064 156
type: UnificationXref
id: P15064
db: uniprot

Alpha-crystallin A chain
type: ProteinReference
xref: uniprot P24622 192
organism: Mus musculus

PTHR24216:SF58
type: RelationshipXref
id: PTHR24216:SF58
db: PANTHER Family
relationship type: By Homology

uniprot Q99PR8 200
type: UnificationXref
id: Q99PR8
db: uniprot

uniprot E2RPB0 222
type: UnificationXref
id: E2RPB0
db: uniprot

uniprot P50393 121
type: UnificationXref
id: P50393
db: uniprot

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot F1MBU9 224
organism: Bos taurus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q8NEB9 287
organism: Homo sapiens

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 92
organism: Homo sapiens

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

uniprot H2RA86 90
type: UnificationXref
id: H2RA86
db: uniprot

uniprot P21708 91
type: UnificationXref
id: P21708
db: uniprot

uniprot F7F5K9 145
type: UnificationXref
id: F7F5K9
db: uniprot

uniprot A0A1D5QUZ8 83
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

uniprot D3ZFJ0 214
type: UnificationXref
id: D3ZFJ0
db: uniprot

uniprot F6Y9I6 470
type: UnificationXref
id: F6Y9I6
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF12
xref: uniprot F1MIA2 464
organism: Bos taurus

NRAS protein
type: ProteinReference
xref: uniprot A5D7R9 128
xref: PTHR24070:SF189
organism: Bos taurus

uniprot A0A1D5R8E9 294
type: UnificationXref
id: A0A1D5R8E9
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q01986 44
organism: Rattus norvegicus

uniprot J9P5W6 36
type: UnificationXref
id: J9P5W6
db: uniprot

PARTICIPANT STOICHIOMETRY r64 562
type: Stoichiometry
physical entity: MAPKAPK2/3
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot A0A1D5QK27 122
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r64 561
type: Stoichiometry
physical entity: MAPKAPK2/3
stoichiometric coefficient: 1.0

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: PTHR23043:SF7
xref: uniprot Q16665 19
organism: Homo sapiens

uniprot F1MBR1 175
type: UnificationXref
id: F1MBR1
db: uniprot

PTHR24356:SF347
type: RelationshipXref
id: PTHR24356:SF347
db: PANTHER Family
relationship type: By Homology

uniprot P14056 347
type: UnificationXref
id: P14056
db: uniprot

P01424
type: UnificationXref
id: P01424
db: PANTHER Pathway Component

P01423
type: UnificationXref
id: P01423
db: PANTHER Pathway Component

uniprot Q7QEJ7 285
type: UnificationXref
id: Q7QEJ7
db: uniprot

P01425
type: UnificationXref
id: P01425
db: PANTHER Pathway Component

PTHR44329:SF193
type: RelationshipXref
id: PTHR44329:SF193
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q9Z1L0 292
xref: PTHR10048:SF33
organism: Rattus norvegicus

Sphingosine kinase 2
type: ProteinReference
xref: uniprot Q9JIA7 70
organism: Mus musculus

GTPase NRas
type: ProteinReference
xref: uniprot P79737 162
xref: PTHR24070:SF189
organism: Danio rerio

Phosphatidylinositol 3-kinase piki-1
type: ProteinReference
xref: PTHR10048:SF64
xref: uniprot G5EDY0 246
organism: Caenorhabditis elegans

uniprot Q05144 414
type: UnificationXref
id: Q05144
db: uniprot

Complex (VEGFR-2/VEGF)
type: Complex
component stoichiometry: VEGF s4 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: VEGFR 2 s3 sa1 STOICHIOMETRY ID COMPLEX
component: VEGFR-2
component: VEGF
feature: COMPLEX BINDING FEATURE s44 a63 540
feature: COMPLEX BINDING FEATURE s44 a63 538
cellular location: cytoplasm

Leupaxin
type: ProteinReference
xref: uniprot O60711 362
organism: Homo sapiens

VEGF signaling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r48
pathway component: STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r62
pathway component: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r68
pathway component: STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r67
pathway component: STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re29
pathway component: HETERODIMER_ASSOCIATION_LEFT__VEGFR_2-_VEGF-RIGHT__Complex__VEGFR_2_VEGF_-_r57
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r66
pathway component: STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_r61
pathway component: STATE_TRANSITION_LEFT__Sck-RIGHT__Sck-_r60
pathway component: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r46
pathway component: STATE_TRANSITION_LEFT__p38MAPK-RIGHT__p38MAPK-_r63
pathway component: STATE_TRANSITION_LEFT__Akt_PKB-RIGHT__Akt_PKB-_r69
pathway component: STATE_TRANSITION_LEFT__Caspase9-RIGHT__Caspase9-_re28
pathway component: STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_r65
pathway component: HETERODIMER_ASSOCIATION_LEFT__Ca2_PLUS_-_PKC-RIGHT__PKC_Ca2_PLUS_-_re30
pathway component: STATE_TRANSITION_LEFT__MAPKAPK2_3-RIGHT__MAPKAPK2_3-_r64
pathway component: STATE_TRANSITION_LEFT__SPK-RIGHT__SPK-_r45
pathway component: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r47
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS_-_eNOS-RIGHT__Complex__eNOS_Ca2_PLUS__endsuper_-_r70
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r55
pathway component: STATE_TRANSITION_LEFT__Erk-RIGHT__Erk-_r49
pathway component: STATE_TRANSITION_LEFT__PLC_gamma-RIGHT__PLC_gamma-_r58
pathway component: STATE_TRANSITION_LEFT__HIF_1-RIGHT__HIF_1-_r53
pathway component: STATE_TRANSITION_LEFT__cPLA2-_Ca2_PLUS_-RIGHT__Complex__cPLA2_endsub_Ca2_PLUS__endsuper_-_r71
pathway component: STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r54
pathway component: STATE_TRANSITION_LEFT__VRAP-RIGHT__VRAP-_r59
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r56
xref: PANTHER Pathway P00056 1
comment: MODEL_NOTES=Panther Pathway: P00056 This pathway represents the signal transduction cascade initiated afterthe vascaular endothelial growth factor (VEGF) binds to its receptor VEGFR-2. VEGF can also bind to VEGFR-1, but less is known about the pathway resulting from the activation of that receptor. Activation of VEGFR-2 results in the increased proliferation, survival and migration of blood endothelial cells required for angiogenesis. Medline=11741095 Medline=12778165 Medline=13678960 PMID: 11741095 PMID: 12778165 PMID: 13678960

uniprot Q16665 19
type: UnificationXref
id: Q16665
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 16

MAPKAPK2 isoform 1
type: ProteinReference
xref: uniprot H2Q104 317
xref: PTHR24349:SF63
organism: Pan troglodytes

uniprot F6YAB9 435
type: UnificationXref
id: F6YAB9
db: uniprot

uniprot H2Q104 317
type: UnificationXref
id: H2Q104
db: uniprot

STATE_TRANSITION_LEFT__PLC_gamma-RIGHT__PLC_gamma-_r58
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 593
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 594
left: PLC-gamma
interaction type: STATE_TRANSITION
right: PLC-gamma

uniprot Q62219 369
type: UnificationXref
id: Q62219
db: uniprot

P01419
type: UnificationXref
id: P01419
db: PANTHER Pathway Component

P01418
type: UnificationXref
id: P01418
db: PANTHER Pathway Component

uniprot P47713 118
type: UnificationXref
id: P47713
db: uniprot

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

Protein kinase C-like 1B
type: ProteinReference
xref: uniprot P34885 504
xref: PTHR24356:SF240
organism: Caenorhabditis elegans

P01417
type: UnificationXref
id: P01417
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
evidence: Evidence 332
evidence: Evidence 331
evidence: Evidence 329
evidence: Evidence 330
xref: uniprot A0A1D5R9U8 328
xref: PTHR44329:SF22
organism: Macaca mulatta

Crystallin alpha B
type: ProteinReference
xref: uniprot E2RNB6 173
organism: Canis lupus familiaris

uniprot O08908 257
type: UnificationXref
id: O08908
db: uniprot

uniprot P29474 429
type: UnificationXref
id: P29474
db: uniprot

P01415
type: UnificationXref
id: P01415
db: PANTHER Pathway Component

P01414
type: UnificationXref
id: P01414
db: PANTHER Pathway Component

P01413
type: UnificationXref
id: P01413
db: PANTHER Pathway Component

Ras protein let-60
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P22981 157
organism: Caenorhabditis elegans

P01412
type: UnificationXref
id: P01412
db: PANTHER Pathway Component

uniprot A8WTA3 399
type: UnificationXref
id: A8WTA3
db: uniprot

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot F1NYZ2 28
organism: Gallus gallus

uniprot Q5XIS9 519
type: UnificationXref
id: Q5XIS9
db: uniprot

uniprot E2RNP2 460
type: UnificationXref
id: E2RNP2
db: uniprot

PARTICIPANT STOICHIOMETRY r55 600
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot H2PZQ7 147
type: UnificationXref
id: H2PZQ7
db: uniprot

PARTICIPANT STOICHIOMETRY r55 602
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

uniprot H2QLV6 406
type: UnificationXref
id: H2QLV6
db: uniprot

PARTICIPANT STOICHIOMETRY r55 601
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

P01421
type: UnificationXref
id: P01421
db: PANTHER Pathway Component

P01422
type: UnificationXref
id: P01422
db: PANTHER Pathway Component

uniprot Q812A5 422
type: UnificationXref
id: Q812A5
db: uniprot

P01420
type: UnificationXref
id: P01420
db: PANTHER Pathway Component

uniprot H2Q0T0 116
type: UnificationXref
id: H2Q0T0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RPB0 222
xref: PTHR10155:SF2
organism: Canis lupus familiaris

P01402
type: UnificationXref
id: P01402
db: PANTHER Pathway Component

P01401
type: UnificationXref
id: P01401
db: PANTHER Pathway Component

P01404
type: UnificationXref
id: P01404
db: PANTHER Pathway Component

P01403
type: UnificationXref
id: P01403
db: PANTHER Pathway Component

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: uniprot F1PHV7 142
xref: PTHR24070:SF189
organism: Canis lupus familiaris

P01406
type: UnificationXref
id: P01406
db: PANTHER Pathway Component

uniprot H2Q383 249
type: UnificationXref
id: H2Q383
db: uniprot

P01405
type: UnificationXref
id: P01405
db: PANTHER Pathway Component

P01408
type: UnificationXref
id: P01408
db: PANTHER Pathway Component

KDR isoform 1
type: ProteinReference
xref: PTHR24416:SF45
xref: uniprot H2QPH6 60
organism: Pan troglodytes

P01407
type: UnificationXref
id: P01407
db: PANTHER Pathway Component

Raf homolog serine/threonine-protein kinase Raf
type: ProteinReference
xref: PTHR44329:SF193
xref: uniprot P11346 346
organism: Drosophila melanogaster

uniprot A0A2I3RKP9 171
type: UnificationXref
id: A0A2I3RKP9
db: uniprot

P01409
type: UnificationXref
id: P01409
db: PANTHER Pathway Component

Nitric oxide synthase, endothelial
type: ProteinReference
xref: uniprot P29474 429
xref: PTHR19384:SF66
organism: Homo sapiens

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 331
xref: uniprot P11345 345
xref: PTHR44329:SF22
organism: Rattus norvegicus

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

NRAS isoform 1
type: ProteinReference
xref: uniprot H2PZQ7 147
xref: PTHR24070:SF189
organism: Pan troglodytes

uniprot Q7ZVK8 54
type: UnificationXref
id: Q7ZVK8
db: uniprot

uniprot Q3UMW7 324
type: UnificationXref
id: Q3UMW7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7DUD6 239
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 440
xref: PTHR24055:SF110
organism: Pan troglodytes

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot Q64143 280
xref: PTHR10155:SF2
organism: Mus musculus

P01410
type: UnificationXref
id: P01410
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r47
controller: Ras

P01411
type: UnificationXref
id: P01411
db: PANTHER Pathway Component

uniprot H2QHR7 483
type: UnificationXref
id: H2QHR7
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6QP11 99
xref: PTHR24356:SF171
organism: Monodelphis domestica

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot A0A3Q1M614 311
xref: PTHR24349:SF63
organism: Bos taurus

uniprot P27704 38
type: UnificationXref
id: P27704
db: uniprot

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot E2RL20 338
organism: Canis lupus familiaris

uniprot P23927 190
type: UnificationXref
id: P23927
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot F6RA79 468
organism: Monodelphis domestica

p38MAPK
type: Protein
entity reference: p38MAPK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 94
organism: Mus musculus

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa4 545
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

STATE_TRANSITION_LEFT__Erk-RIGHT__Erk-_r49
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 571
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 572
left: Erk
interaction type: STATE_TRANSITION
right: Erk

ncbitaxon 6669 135
type: UnificationXref
id: 6669
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A8XTZ1 297
organism: Caenorhabditis briggsae

uniprot A0A1D5Q8X5 353
type: UnificationXref
id: A0A1D5Q8X5
db: uniprot

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

GTPase NRas
type: ProteinReference
xref: uniprot Q04970 163
xref: PTHR24070:SF189
organism: Rattus norvegicus

uniprot Q99PD6 375
type: UnificationXref
id: Q99PD6
db: uniprot

PARTICIPANT STOICHIOMETRY r67 555
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot Q15139 516
type: UnificationXref
id: Q15139
db: uniprot

PARTICIPANT STOICHIOMETRY r67 556
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

Ras-like protein rasD
type: ProteinReference
xref: uniprot P03967 151
xref: PTHR24070:SF418
organism: Dictyostelium discoideum

Protein CBR-KIN-32
type: ProteinReference
xref: uniprot A8XBU1 389
organism: Caenorhabditis briggsae

Transforming growth factor beta-1-induced transcript 1 protein
type: ProteinReference
xref: uniprot Q99PD6 375
organism: Rattus norvegicus

HSP27
type: ProteinReference
xref: P01412
standard name: Heat-Shock Protein 27
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Heat-Shock Protein 27 Synonym: HSPB1 Accession: P01412
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.HSP27
member entity reference: alpha-crystallin A chain-like
member entity reference: AGAP007158-PA
member entity reference: Crystallin alpha B
member entity reference: Heat shock protein beta-1
member entity reference: Alpha-crystallin B chain
member entity reference: Alpha-crystallin A chain
member entity reference: Uncharacterized protein
member entity reference: CRYAA isoform 1
member entity reference: Heat shock protein beta-2
member entity reference: Alpha A crystallin
member entity reference: AGAP005547-PA
member entity reference: Heat shock 27kDa protein 2
member entity reference: HSPB2 isoform 1
member entity reference: Heat shock protein family B (small) member 2
member entity reference: AGAP005548-PA
member entity reference: CRYAB isoform 1
member entity reference: Alpha b crystallin

uniprot P32254 161
type: UnificationXref
id: P32254
db: uniprot

uniprot P10398 344
type: UnificationXref
id: P10398
db: uniprot

MAPKAPK3 isoform 1
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot H2QMP5 318
organism: Pan troglodytes

uniprot A0A3Q1N508 388
type: UnificationXref
id: A0A3Q1N508
db: uniprot

uniprot A0A3Q1LJJ3 378
type: UnificationXref
id: A0A3Q1LJJ3
db: uniprot

MEK
type: ProteinReference
xref: P01402
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.MEK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: MAPK/ERK Kinase Synonym: MAP2K,MAPKK,MKK,Mitogen-Activated Protein Kinase Kinase,PRKMK,Protein Kinase, Mitogen-Activated, Kinase Accession: P01402
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: MAP2K1 protein
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: MAP2K2 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Mitogen-activated protein kinase kinase 2

uniprot A0A3Q1LSD1 426
type: UnificationXref
id: A0A3Q1LSD1
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 3
type: ProteinReference
xref: uniprot A0A2I3RH39 206
xref: PTHR10155:SF2
organism: Pan troglodytes

Alpha A crystallin
type: ProteinReference
xref: uniprot Q8UUZ6 199
organism: Danio rerio

HETERODIMER_ASSOCIATION_LEFT__VEGFR_2-_VEGF-RIGHT__Complex__VEGFR_2_VEGF_-_r57
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 596
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 595
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 597
left: VEGFR-2
left: VEGF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (VEGFR-2/VEGF)

STATE_TRANSITION_LEFT__SPK-RIGHT__SPK-_r45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 579
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 580
left: SPK
interaction type: STATE_TRANSITION
right: SPK

uniprot P49023 363
type: UnificationXref
id: P49023
db: uniprot

uniprot E2RR18 461
type: UnificationXref
id: E2RR18
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPKAPK2_3-RIGHT__MAPKAPK2_3-_r64
controller: p38MAPK

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot G5E577 35
organism: Bos taurus

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q62074 520
organism: Mus musculus

Leupaxin
type: ProteinReference
xref: uniprot Q99N69 374
organism: Mus musculus

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 14

uniprot F1MWF1 56
type: UnificationXref
id: F1MWF1
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot Q62077 308
organism: Mus musculus

eco ECO:0000316 21
type: UnificationXref
id: ECO:0000316
db: eco

uniprot Q9QXK9 78
type: UnificationXref
id: Q9QXK9
db: uniprot

STATE_TRANSITION_LEFT__VRAP-RIGHT__VRAP-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 592
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 591
left: VRAP
interaction type: STATE_TRANSITION
right: VRAP

uniprot A0A2I3T3L8 386
type: UnificationXref
id: A0A2I3T3L8
db: uniprot

uniprot O00443 254
type: UnificationXref
id: O00443
db: uniprot

uniprot A0A1D5QE27 204
type: UnificationXref
id: A0A1D5QE27
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 90
organism: Pan troglodytes

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot E1B7L9 453
xref: PTHR22968:SF26
organism: Bos taurus

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P04627 342
xref: PTHR44329:SF55
organism: Mus musculus

uniprot A0A3Q3ACS4 212
type: UnificationXref
id: A0A3Q3ACS4
db: uniprot

uniprot H2QMP5 318
type: UnificationXref
id: H2QMP5
db: uniprot

cPLA2 s7 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cPLA2
stoichiometric coefficient: 1.0

uniprot F6VAQ8 232
type: UnificationXref
id: F6VAQ8
db: uniprot

PTHR24070:SF206
type: RelationshipXref
id: PTHR24070:SF206
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot G7MGQ5 247
xref: PTHR10155:SF2
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r66
controller: Complex (VEGFR-2/VEGF)

uniprot P47811 437
type: UnificationXref
id: P47811
db: uniprot

uniprot P67964 81
type: UnificationXref
id: P67964
db: uniprot

PTHR24070:SF418
type: RelationshipXref
id: PTHR24070:SF418
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot F7GTQ2 476
xref: PTHR22968:SF26
organism: Macaca mulatta

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 330
xref: PTHR44329:SF22
xref: uniprot P05625 343
organism: Gallus gallus

uniprot Q04970 163
type: UnificationXref
id: Q04970
db: uniprot

Protein C-ets-1
type: ProteinReference
xref: uniprot P27577 384
xref: PTHR11849:SF209
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r65 559
type: Stoichiometry
physical entity: HSP27
stoichiometric coefficient: 1.0

p38MAPK
type: ProteinReference
xref: P01423
standard name: p38 Mitogen-Activated Protein Kinase
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.p38MAPK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: p38 Mitogen-Activated Protein Kinase Synonym: CSAID-Binding Protein 1,CSBP1,Cytokine-Suppressive Anti-Inflammatory Drug-Binding Protein 1,MAPK14,MXI2,Mitogen-Activated Protein Kinase 14,RK,SAPK2A,Stress-Activated Protein Kinase 2A,p38,p38-Alpha Accession: P01423
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 14B
member entity reference: Mitogen-activated protein kinase 14A

uniprot P15056 348
type: UnificationXref
id: P15056
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot P41743 505
organism: Homo sapiens

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot P31749 103
type: UnificationXref
id: P31749
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot D4A229 452
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re29 582
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

Sphingosine kinase 2
type: ProteinReference
xref: uniprot Q9NRA0 71
organism: Homo sapiens

uniprot F7HAF3 115
type: UnificationXref
id: F7HAF3
db: uniprot

PARTICIPANT STOICHIOMETRY re29 581
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot K7CBH8 485
xref: PTHR24356:SF159
organism: Pan troglodytes

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE1 441
organism: Danio rerio

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: uniprot Q9DGE2 442
xref: PTHR24055:SF110
organism: Danio rerio

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

PTHR22968:SF26
type: RelationshipXref
id: PTHR22968:SF26
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6YAB9 435
xref: PTHR24055:SF110
organism: Monodelphis domestica

FAK
type: ProteinReference
xref: P01420
standard name: Focal Adhesion Kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Focal Adhesion Kinase Synonym: Cytoplasmic Protein-Tyrosine Kinase ,FAK1,Focal Adhesion Kinase 1,PTK2 Accession: P01420
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.FAK
member entity reference: Protein tyrosine kinase 2
member entity reference: Focal adhesion kinase 1
member entity reference: Protein tyrosine kinase 2ab
member entity reference: Inactive tyrosine-protein kinase kin-32
member entity reference: Protein CBR-KIN-32

uniprot E2REI6 337
type: UnificationXref
id: E2REI6
db: uniprot

PTHR44329:SF55
type: RelationshipXref
id: PTHR44329:SF55
db: PANTHER Family
relationship type: By Homology

PTHR24070:SF420
type: RelationshipXref
id: PTHR24070:SF420
db: PANTHER Family
relationship type: By Homology

ncbitaxon 10116 18
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot F1M7Y5 462
type: UnificationXref
id: F1M7Y5
db: uniprot

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

Ca2+
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

uniprot P34722 503
type: UnificationXref
id: P34722
db: uniprot

uniprot D3ZTF6 215
type: UnificationXref
id: D3ZTF6
db: uniprot

uniprot P15692 80
type: UnificationXref
id: P15692
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XT65 32
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r65 560
type: Stoichiometry
physical entity: HSP27
stoichiometric coefficient: 1.0

uniprot A0A3Q1M353 335
type: UnificationXref
id: A0A3Q1M353
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O35904 258
xref: PTHR10048:SF35
organism: Mus musculus

uniprot Q9TUX8 432
type: UnificationXref
id: Q9TUX8
db: uniprot

uniprot P42930 193
type: UnificationXref
id: P42930
db: uniprot

Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
type: ProteinReference
xref: uniprot D3ZTF6 215
xref: PTHR10048:SF28
organism: Rattus norvegicus

uniprot Q9WTQ0 529
type: UnificationXref
id: Q9WTQ0
db: uniprot

uniprot F7EP57 240
type: UnificationXref
id: F7EP57
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7HC75 478
xref: PTHR24356:SF181
organism: Macaca mulatta

Ets
type: Protein
entity reference: Ets
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PI3K
type: Protein
entity reference: PI3K
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR22968:SF12
type: RelationshipXref
id: PTHR22968:SF12
db: PANTHER Family
relationship type: By Homology

PTHR44329:SF47
type: RelationshipXref
id: PTHR44329:SF47
db: PANTHER Family
relationship type: By Homology

uniprot K7ALD7 148
type: UnificationXref
id: K7ALD7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N871 57
organism: Gallus gallus

VEGFR-2
type: Protein
entity reference: VEGFR-2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O00459 255
type: UnificationXref
id: O00459
db: uniprot

uniprot H2PXY8 248
type: UnificationXref
id: H2PXY8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HIF_1-RIGHT__HIF_1-_r53
controller: Erk

uniprot P36507 41
type: UnificationXref
id: P36507
db: uniprot

uniprot P16054 497
type: UnificationXref
id: P16054
db: uniprot

uniprot P26450 265
type: UnificationXref
id: P26450
db: uniprot

HIF-1
type: ProteinReference
xref: P01401
standard name: Hypoxia-Inducible Factor 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.HIF-1
comment: ENTITY_REFERENCE_NOTES= Long Name: Hypoxia-Inducible Factor 1 Synonym: MOP1,Member of PAS Superfamily 1 Accession: P01401
member entity reference: Hypoxia-inducible factor 1-alpha
member entity reference: Uncharacterized protein
member entity reference: HIF1A isoform 7
member entity reference: Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)
member entity reference: Hypoxia inducible factor 1 subunit alpha

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS_-_eNOS-RIGHT__Complex__eNOS_Ca2_PLUS__endsuper_-_r70
controller: Akt/PKB

uniprot Q04759 512
type: UnificationXref
id: Q04759
db: uniprot

PTHR10336:SF25
type: RelationshipXref
id: PTHR10336:SF25
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: RelationshipTypeVocabulary

Paxillin
type: ProteinReference
xref: uniprot P49023 363
xref: PTHR24216:SF11
organism: Homo sapiens

uniprot Q5M852 368
type: UnificationXref
id: Q5M852
db: uniprot

Protein tyrosine kinase 2ab
type: ProteinReference
xref: uniprot A0A2R8RR02 387
xref: PTHR24418:SF78
organism: Danio rerio

Paxillin
type: ProteinReference
xref: uniprot P49024 364
xref: PTHR24216:SF11
organism: Gallus gallus

BAD
type: Protein
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot E2RIF9 221
organism: Canis lupus familiaris

PTHR10155:SF3
type: RelationshipXref
id: PTHR10155:SF3
db: PANTHER Family
relationship type: By Homology

PIK3C2A isoform 5
type: ProteinReference
xref: uniprot H2Q383 249
xref: PTHR10048:SF28
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r46
controller: SPK

AGAP002219-PA
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot Q7QK91 168
organism: Anopheles gambiae

STATE_TRANSITION_LEFT__Caspase9-RIGHT__Caspase9-_re28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 584
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 583
left: Caspase9
interaction type: STATE_TRANSITION
right: Caspase9

uniprot F6SW23 229
type: UnificationXref
id: F6SW23
db: uniprot

ncbitaxon 9031 10
type: UnificationXref
id: 9031
db: ncbitaxon

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot F1MY82 465
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot A0A3Q2U4X3 97
organism: Gallus gallus

PTHR10155:SF2
type: RelationshipXref
id: PTHR10155:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF1
type: RelationshipXref
id: PTHR10155:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q7PMF0 284
type: UnificationXref
id: Q7PMF0
db: uniprot

uniprot F7EH19 33
type: UnificationXref
id: F7EH19
db: uniprot

Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q5FWK3 418
organism: Mus musculus

uniprot P34152 394
type: UnificationXref
id: P34152
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot H2QDQ1 482
xref: PTHR24356:SF193
organism: Pan troglodytes

uniprot A4IFJ5 108
type: UnificationXref
id: A4IFJ5
db: uniprot

DAG
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

uniprot F1N871 57
type: UnificationXref
id: F1N871
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A2I3SHP7 295
organism: Pan troglodytes

uniprot F6RWK1 401
type: UnificationXref
id: F6RWK1
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P19174 306
organism: Homo sapiens

uniprot Q16539 439
type: UnificationXref
id: Q16539
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot Q6RUV5 421
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A1D5QE27 204
xref: PTHR10048:SF7
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r45 580
type: Stoichiometry
physical entity: SPK
stoichiometric coefficient: 1.0

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot P15153 407
organism: Homo sapiens

Uncharacterized protein rasD
type: ProteinReference
xref: PTHR24070:SF418
xref: uniprot F0ZB76 136
organism: Dictyostelium purpureum

uniprot P35918 61
type: UnificationXref
id: P35918
db: uniprot

uniprot P41156 385
type: UnificationXref
id: P41156
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 132

ncbitaxon 9913 6
type: UnificationXref
id: 9913
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot F7EP57 240
organism: Macaca mulatta

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 158

ncbitaxon 7227 107
type: UnificationXref
id: 7227
db: ncbitaxon

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot F6PX17 314
organism: Ornithorhynchus anatinus

uniprot Q95YD4 397
type: UnificationXref
id: Q95YD4
db: uniprot

uniprot P54676 275
type: UnificationXref
id: P54676
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q8BTI9 286
xref: PTHR10048:SF33
organism: Mus musculus

uniprot A0A1D5R9U8 328
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A0G2K5T3 203
xref: PTHR10048:SF107
organism: Rattus norvegicus

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 332
evidence: Evidence 331
evidence: Evidence 329
evidence: Evidence 330
xref: uniprot E2REI6 337
xref: PTHR44329:SF22
organism: Canis lupus familiaris

uniprot A0A3Q1LQK4 211
type: UnificationXref
id: A0A3Q1LQK4
db: uniprot

PARTICIPANT STOICHIOMETRY r45 579
type: Stoichiometry
physical entity: SPK
stoichiometric coefficient: 1.0

Nitric oxide synthase
type: ProteinReference
xref: uniprot F6S3S1 427
xref: PTHR19384:SF66
organism: Monodelphis domestica

uniprot A0A2I3SHP7 295
type: UnificationXref
id: A0A2I3SHP7
db: uniprot

uniprot F1NCY7 312
type: UnificationXref
id: F1NCY7
db: uniprot

uniprot F1PZ54 11
type: UnificationXref
id: F1PZ54
db: uniprot

uniprot Q2XPT7 64
type: UnificationXref
id: Q2XPT7
db: uniprot

uniprot E2RJX4 98
type: UnificationXref
id: E2RJX4
db: uniprot

Heat shock 27kDa protein 2
type: ProteinReference
xref: uniprot F1MBR1 175
organism: Bos taurus

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O08908 257
organism: Mus musculus

Focal adhesion kinase 1
type: ProteinReference
xref: uniprot O35346 393
xref: PTHR24418:SF78
organism: Rattus norvegicus

Rho GTPase-activating protein 8
type: ProteinReference
xref: uniprot Q9CXP4 423
organism: Mus musculus

uniprot Q7PZG1 326
type: UnificationXref
id: Q7PZG1
db: uniprot

Nitric oxide synthase, endothelial
type: ProteinReference
xref: uniprot P70313 430
xref: PTHR19384:SF66
organism: Mus musculus

uniprot Q61221 22
type: UnificationXref
id: Q61221
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F6Z0J4 236
organism: Xenopus tropicalis

Akt/PKB
type: Protein
entity reference: Akt/PKB
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 87
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 85
organism: Canis lupus familiaris

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 109
xref: uniprot A4IFJ5 108
xref: PTHR10728:SF13
organism: Bos taurus

CRYAA isoform 1
type: ProteinReference
xref: uniprot A0A2I3RKP9 171
organism: Pan troglodytes

Protein CBR-RGA-1
type: ProteinReference
xref: uniprot A8WTA3 399
organism: Caenorhabditis briggsae

uniprot P35968 62
type: UnificationXref
id: P35968
db: uniprot

uniprot H2Q8F2 480
type: UnificationXref
id: H2Q8F2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC_gamma-RIGHT__PLC_gamma-_r58
controller: Complex (VEGFR-2/VEGF)

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
type: ProteinReference
xref: uniprot D3ZVF3 216
xref: PTHR10048:SF30
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r54
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 603
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 604
left: Ets
interaction type: STATE_TRANSITION
right: Ets

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P04792 188
organism: Homo sapiens

uniprot F6RRK4 177
type: UnificationXref
id: F6RRK4
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot Q63789 279
xref: PTHR10155:SF2
organism: Rattus norvegicus

uniprot H2QDQ1 482
type: UnificationXref
id: H2QDQ1
db: uniprot

uniprot F7BIC2 472
type: UnificationXref
id: F7BIC2
db: uniprot

uniprot H2QVM2 428
type: UnificationXref
id: H2QVM2
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot Q63788 278
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P32871 267
xref: PTHR10048:SF107
organism: Bos taurus

TRANSPORT
type: RelationshipTypeVocabulary

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot F7FGD2 475
xref: PTHR22968:SF26
organism: Monodelphis domestica

uniprot Q9NYA1 72
type: UnificationXref
id: Q9NYA1
db: uniprot

uniprot P34885 504
type: UnificationXref
id: P34885
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RWK1 401
organism: Bos taurus

uniprot P04792 188
type: UnificationXref
id: P04792
db: uniprot

Ras-like protein rasB
type: ProteinReference
xref: PTHR24070:SF206
xref: uniprot P32252 159
organism: Dictyostelium discoideum

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot E1BE66 218
organism: Bos taurus

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re29
control type: INHIBITION
controller: Akt/PKB

Ras-like protein rasS
type: ProteinReference
xref: uniprot P32254 161
xref: PTHR24070:SF380
organism: Dictyostelium discoideum

AGAP000018-PA
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q7QEJ7 285
organism: Anopheles gambiae

Ras-like protein rasC
type: ProteinReference
xref: uniprot P32253 160
xref: PTHR24070:SF251
organism: Dictyostelium discoideum

uniprot O35878 182
type: UnificationXref
id: O35878
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q90XF2 527
organism: Danio rerio

uniprot Q9DGE1 441
type: UnificationXref
id: Q9DGE1
db: uniprot

uniprot A0A1D5QLW6 293
type: UnificationXref
id: A0A1D5QLW6
db: uniprot

uniprot E1BE66 218
type: UnificationXref
id: E1BE66
db: uniprot

uniprot P09217 495
type: UnificationXref
id: P09217
db: uniprot

uniprot O35800 17
type: UnificationXref
id: O35800
db: uniprot

Rac
type: ProteinReference
xref: P01421
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_NOTES= Long Name: Rho GTPase Synonym: CDC42,Cell Division Cycle 42 Accession: P01421
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Rac
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Rho GTPase activating protein 1
member entity reference: Rho GTPase-activating protein 8
member entity reference: Ras-related C3 botulinum toxin substrate 3
member entity reference: Rho-GTPase-activating protein 8
member entity reference: Rho GTPase-activating protein 1
member entity reference: Rac family small GTPase 2
member entity reference: Proline rich 5
member entity reference: Uncharacterized protein
member entity reference: Proline-rich protein 5
member entity reference: Protein CBR-RGA-1
member entity reference: Cdc42 GTPase-activating protein
member entity reference: Rho GTPase-activating protein 68F
member entity reference: Rho GTPase Activating protein
member entity reference: ARHGAP1 isoform 3
member entity reference: Ras-related C3 botulinum toxin substrate 2

uniprot P63001 411
type: UnificationXref
id: P63001
db: uniprot

uniprot Q02956 511
type: UnificationXref
id: Q02956
db: uniprot

PLC-gamma
type: Protein
entity reference: PLC-gamma
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6RA79 468
type: UnificationXref
id: F6RA79
db: uniprot

VRAP
type: Protein
entity reference: VRAP
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Proline-rich protein 5
type: ProteinReference
xref: uniprot Q812A5 422
organism: Mus musculus

uniprot Q05397 396
type: UnificationXref
id: Q05397
db: uniprot

uniprot A0A0G2K344 202
type: UnificationXref
id: A0A0G2K344
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot E1BMX0 133
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ATA8 179
organism: Monodelphis domestica

uniprot Q7K3H0 282
type: UnificationXref
id: Q7K3H0
db: uniprot

STATE_TRANSITION_LEFT__Ca2_PLUS_-_eNOS-RIGHT__Complex__eNOS_Ca2_PLUS__endsuper_-_r70
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 588
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 589
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 590
left: Ca2+
left: eNOS
interaction type: STATE_TRANSITION
right: Complex (eNOS/Ca2+_endsuper)

PTHR24349:SF63
type: RelationshipXref
id: PTHR24349:SF63
db: PANTHER Family
relationship type: By Homology

PTHR24349:SF64
type: RelationshipXref
id: PTHR24349:SF64
db: PANTHER Family
relationship type: By Homology

uniprot P24622 192
type: UnificationXref
id: P24622
db: uniprot

Transforming growth factor beta 1 induced transcript 1
type: ProteinReference
xref: uniprot E2RTE0 359
organism: Canis lupus familiaris

uniprot E1B7L9 453
type: UnificationXref
id: E1B7L9
db: uniprot

uniprot Q63788 278
type: UnificationXref
id: Q63788
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6T0E0 402
organism: Macaca mulatta

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

uniprot Q3MHZ4 366
type: UnificationXref
id: Q3MHZ4
db: uniprot

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: uniprot Q3UMW7 324
xref: PTHR24349:SF64
organism: Mus musculus

uniprot A0A2I3SDP5 355
type: UnificationXref
id: A0A2I3SDP5
db: uniprot

uniprot A5D7R9 128
type: UnificationXref
id: A5D7R9
db: uniprot

CRYAB isoform 1
type: ProteinReference
xref: uniprot A0A2J8L0C8 172
organism: Pan troglodytes

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot Q3SYZ2 323
organism: Bos taurus

Vascular endothelial growth factor A-A
type: ProteinReference
xref: uniprot O73682 79
organism: Danio rerio

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

PTHR11849:SF209
type: RelationshipXref
id: PTHR11849:SF209
db: PANTHER Family
relationship type: By Homology

HSP27
type: Protein
entity reference: HSP27
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q99N57 352
type: UnificationXref
id: Q99N57
db: uniprot

PTHR24416:SF45
type: RelationshipXref
id: PTHR24416:SF45
db: PANTHER Family
relationship type: By Homology

uniprot F6Z0J4 236
type: UnificationXref
id: F6Z0J4
db: uniprot

uniprot P68280 194
type: UnificationXref
id: P68280
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P14056 347
xref: PTHR44329:SF55
organism: Rattus norvegicus

uniprot Q99N69 374
type: UnificationXref
id: Q99N69
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F1M7Y5 462
organism: Rattus norvegicus

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot P02511 187
organism: Homo sapiens

uniprot A8WR64 451
type: UnificationXref
id: A8WR64
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 31

uniprot A0A1D5QZZ0 73
type: UnificationXref
id: A0A1D5QZZ0
db: uniprot

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot P02510 186
organism: Bos taurus

uniprot F7FH70 381
type: UnificationXref
id: F7FH70
db: uniprot

Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)
type: ProteinReference
xref: uniprot A0JND0 5
xref: PTHR23043:SF7
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: uniprot F1NG47 466
xref: PTHR24356:SF159
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Sck-RIGHT__Sck-_r60
controller: Complex (VEGFR-2/VEGF)

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot F7BIC2 472
xref: PTHR24356:SF159
organism: Macaca mulatta

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 178

Alpha-crystallin A chain
type: ProteinReference
xref: uniprot P02504 185
organism: Gallus gallus

uniprot Q7Q724 198
type: UnificationXref
id: Q7Q724
db: uniprot

Vascular endothelial growth factor A
type: ProteinReference
xref: uniprot Q00731 82
organism: Mus musculus

Protein kinase C eta type
type: ProteinReference
xref: uniprot E2RGU7 459
xref: PTHR24356:SF192
organism: Canis lupus familiaris

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 24
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 a17 535
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7EI48 87
type: UnificationXref
id: F7EI48
db: uniprot

uniprot E1BWA3 456
type: UnificationXref
id: E1BWA3
db: uniprot

VEGF
type: Protein
entity reference: VEGF
comment: SPECIES_TYPE=PROTEIN

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05129 490
organism: Homo sapiens

uniprot F7DVL1 474
type: UnificationXref
id: F7DVL1
db: uniprot

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 383

GTPase HRas
type: ProteinReference
xref: uniprot Q61411 167
xref: PTHR24070:SF385
organism: Mus musculus

GTPase NRas
type: ProteinReference
xref: uniprot P08556 153
xref: PTHR24070:SF189
organism: Mus musculus

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05126 488
xref: PTHR24356:SF158
organism: Bos taurus

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: PTHR23043:SF7
xref: uniprot Q61221 22
organism: Mus musculus

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: uniprot P05128 489
xref: PTHR24356:SF162
organism: Bos taurus

uniprot E2RH85 220
type: UnificationXref
id: E2RH85
db: uniprot

uniprot Q8UUZ6 199
type: UnificationXref
id: Q8UUZ6
db: uniprot

uniprot Q28EW2 164
type: UnificationXref
id: Q28EW2
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7G3I5 243
xref: PTHR10048:SF107
organism: Monodelphis domestica

uniprot F1NHL1 467
type: UnificationXref
id: F1NHL1
db: uniprot

PARTICIPANT STOICHIOMETRY re28 583
type: Stoichiometry
physical entity: Caspase9
stoichiometric coefficient: 1.0

Transforming growth factor beta 1 induced transcript 1
type: ProteinReference
xref: uniprot A0A2I3SRD0 356
organism: Pan troglodytes

uniprot H2R8K0 75
type: UnificationXref
id: H2R8K0
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 2
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot H2QFS6 250
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re28 584
type: Stoichiometry
physical entity: Caspase9
stoichiometric coefficient: 1.0

uniprot F1NG47 466
type: UnificationXref
id: F1NG47
db: uniprot

uniprot Q8K1Y2 526
type: UnificationXref
id: Q8K1Y2
db: uniprot

Phospholipase A2
type: ProteinReference
evidence: Evidence 109
xref: PTHR10728:SF13
xref: uniprot F7EEZ1 114
organism: Macaca mulatta

PI3K
type: ProteinReference
xref: P01413
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.PI3K
comment: ENTITY_REFERENCE_NOTES= Long Name: Phosphatidylinositol 3-Kinase Synonym: Synonym not specified Accession: P01413
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: LD28067p
member entity reference: Phosphatidylinositol 3-kinase 2
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
member entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: Phosphatidylinositol 3-kinase age-1
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit gamma
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit beta
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
member entity reference: Phosphatidylinositol 3-kinase 1
member entity reference: Phosphoinositide-3-kinase regulatory subunit 1
member entity reference: Phosphoinositide-3-kinase regulatory subunit 2
member entity reference: PIK3C2A isoform 5
member entity reference: Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
member entity reference: AGAP000018-PA
member entity reference: PIK3CG isoform 1
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
member entity reference: Phosphoinositide-3-kinase regulatory subunit 3
member entity reference: Pi3K21B, isoform B
member entity reference: Phosphatidylinositol 3-kinase 3
member entity reference: PI-3 kinase

uniprot Q8INB9 106
type: UnificationXref
id: Q8INB9
db: uniprot

Caspase9
type: Protein
entity reference: Caspase9
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Ca2 PLUS s73 a32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PKC
type: Protein
entity reference: PKC
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 109
xref: PTHR10728:SF13
xref: uniprot P50393 121
organism: Rattus norvegicus

PTHR10048:SF7
type: RelationshipXref
id: PTHR10048:SF7
db: PANTHER Family
relationship type: By Homology

Cytosolic phospholipase A2
type: ProteinReference
xref: uniprot P50392 120
xref: PTHR10728:SF13
organism: Danio rerio

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 499
organism: Mus musculus

PTHR10728:SF13
type: RelationshipXref
id: PTHR10728:SF13
db: PANTHER Family
relationship type: By Homology

uniprot H2QNG6 251
type: UnificationXref
id: H2QNG6
db: uniprot

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot A0A3Q1M353 335
organism: Bos taurus

Protein CBR-LET-60
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot A8X0X5 131
organism: Caenorhabditis briggsae

ncbitaxon 8364 34
type: UnificationXref
id: 8364
db: ncbitaxon

PTHR12358:SF47
type: RelationshipXref
id: PTHR12358:SF47
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_r65
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 559
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 560
left: HSP27
interaction type: STATE_TRANSITION
right: HSP27

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot E2R428 458
organism: Canis lupus familiaris

uniprot Q9XT09 55
type: UnificationXref
id: Q9XT09
db: uniprot

uniprot P02510 186
type: UnificationXref
id: P02510
db: uniprot

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P42930 193
organism: Rattus norvegicus

Protein kinase C, brain isozyme
type: ProteinReference
xref: uniprot P05130 491
xref: PTHR24356:SF390
organism: Drosophila melanogaster

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF9
xref: uniprot F6Y9I6 470
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot H2QKD0 302
organism: Pan troglodytes

MAPKAPK2/3
type: Protein
entity reference: MAPKAPK2/3
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6QP11 99
type: UnificationXref
id: F6QP11
db: uniprot

Serine/threonine-protein kinase D2
type: ProteinReference
xref: PTHR22968:SF12
xref: uniprot Q9BZL6 528
organism: Homo sapiens

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P10398 344
organism: Homo sapiens

Heat shock protein family B (small) member 2
type: ProteinReference
xref: uniprot E2RTA9 174
organism: Canis lupus familiaris

uniprot F1MDC9 463
type: UnificationXref
id: F1MDC9
db: uniprot

uniprot D4A229 452
type: UnificationXref
id: D4A229
db: uniprot

uniprot O70167 260
type: UnificationXref
id: O70167
db: uniprot

Transforming growth factor beta-1-induced transcript 1 protein
type: ProteinReference
xref: uniprot Q3MHZ4 366
organism: Bos taurus

Focal adhesion kinase 1
type: ProteinReference
xref: uniprot Q00944 395
xref: PTHR24418:SF78
organism: Gallus gallus

uniprot A8XTZ1 297
type: UnificationXref
id: A8XTZ1
db: uniprot

uniprot P54673 272
type: UnificationXref
id: P54673
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 437
xref: PTHR24055:SF110
organism: Mus musculus

uniprot A0JND0 5
type: UnificationXref
id: A0JND0
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot Q92569 288
xref: PTHR10155:SF2
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SPK-RIGHT__SPK-_r45
controller: PKC/Ca2+

alpha-crystallin A chain-like
type: ProteinReference
xref: uniprot F6RRK4 177
organism: Ciona intestinalis

uniprot Q08BT6 515
type: UnificationXref
id: Q08BT6
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot O88763 262
organism: Rattus norvegicus

Evidence 329
type: Evidence
evidence code: ISS
comment: SPACC P04049

uniprot A8X7Y4 358
type: UnificationXref
id: A8X7Y4
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 332
evidence: Evidence 331
evidence: Evidence 329
evidence: Evidence 330
xref: PTHR44329:SF22
xref: uniprot A0A2I3THL4 333
organism: Pan troglodytes

cPLA2
type: Protein
entity reference: cPLA2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P23298 500
type: UnificationXref
id: P23298
db: uniprot

FAK
type: Protein
entity reference: FAK
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r69 552
type: Stoichiometry
physical entity: Akt/PKB
stoichiometric coefficient: 1.0

uniprot Q9BZL6 528
type: UnificationXref
id: Q9BZL6
db: uniprot

uniprot Q01986 44
type: UnificationXref
id: Q01986
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7GAP5 244
xref: PTHR10048:SF33
organism: Ornithorhynchus anatinus

Evidence 332
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

uniprot F7BFL2 315
type: UnificationXref
id: F7BFL2
db: uniprot

Evidence 331
type: Evidence
evidence code: ISS
comment: SPACC P11345

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 91
organism: Rattus norvegicus

Evidence 330
type: Evidence
evidence code: ISS
comment: SPACC P05625

PTHR10728:SF32
type: RelationshipXref
id: PTHR10728:SF32
db: PANTHER Family
relationship type: By Homology

uniprot P05126 488
type: UnificationXref
id: P05126
db: uniprot

uniprot F7BBM1 237
type: UnificationXref
id: F7BBM1
db: uniprot

uniprot F7BVQ1 301
type: UnificationXref
id: F7BVQ1
db: uniprot

uniprot Q8VI36 373
type: UnificationXref
id: Q8VI36
db: uniprot

uniprot Q63844 94
type: UnificationXref
id: Q63844
db: uniprot

PARTICIPANT STOICHIOMETRY r69 551
type: Stoichiometry
physical entity: Akt/PKB
stoichiometric coefficient: 1.0

uniprot Q9Z1L0 292
type: UnificationXref
id: Q9Z1L0
db: uniprot

uniprot P63319 507
type: UnificationXref
id: P63319
db: uniprot

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

uniprot A0A3Q1MBG6 66
type: UnificationXref
id: A0A3Q1MBG6
db: uniprot

uniprot Q9CXP4 423
type: UnificationXref
id: Q9CXP4
db: uniprot

uniprot F6QM53 228
type: UnificationXref
id: F6QM53
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
type: ProteinReference
xref: uniprot O00750 256
xref: PTHR10048:SF30
organism: Homo sapiens

Protein C-ets-1
type: ProteinReference
xref: uniprot P14921 382
xref: PTHR11849:SF209
organism: Homo sapiens

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

Phospholipase A2
type: ProteinReference
xref: uniprot F6QDY0 110
xref: PTHR10728:SF13
organism: Ornithorhynchus anatinus

uniprot G7MGQ5 247
type: UnificationXref
id: G7MGQ5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O00329 253
xref: PTHR10048:SF35
organism: Homo sapiens

PTHR24070:SF251
type: RelationshipXref
id: PTHR24070:SF251
db: PANTHER Family
relationship type: By Homology

Danio rerio
type: BioSource
xref: ncbitaxon 7955 53

Nitric oxide synthase, endothelial
type: ProteinReference
xref: uniprot Q9TUX8 432
xref: PTHR19384:SF66
organism: Canis lupus familiaris

CASP9 isoform 4
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot A0A2I3TJU8 123
organism: Pan troglodytes

uniprot O00329 253
type: UnificationXref
id: O00329
db: uniprot

Protein tyrosine kinase 2
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot E2RGQ1 390
organism: Canis lupus familiaris

SH2 domain containing 2A
type: ProteinReference
evidence: Evidence 74
xref: PTHR14388:SF9
xref: uniprot H2R8K0 75
organism: Pan troglodytes

uniprot P54675 274
type: UnificationXref
id: P54675
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q3ACS4 212
xref: PTHR10155:SF3
organism: Gallus gallus

uniprot P41743 505
type: UnificationXref
id: P41743
db: uniprot

Protein kinase C, eye isozyme
type: ProteinReference
xref: uniprot P13677 496
xref: PTHR24356:SF390
organism: Drosophila melanogaster

HSP27
type: Protein
entity reference: HSP27
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q66H84 325
type: UnificationXref
id: Q66H84
db: uniprot

uniprot F7FDA0 242
type: UnificationXref
id: F7FDA0
db: uniprot

uniprot F1PZ82 313
type: UnificationXref
id: F1PZ82
db: uniprot

Cdc42 GTPase-activating protein
type: ProteinReference
xref: uniprot A4GT58 398
organism: Canis lupus familiaris

Rho GTPase-activating protein 68F
type: ProteinReference
xref: uniprot Q9VTU3 424
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__Sck-RIGHT__Sck-_r60
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 570
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 569
left: Sck
interaction type: STATE_TRANSITION
right: Sck

uniprot H2Q3I0 405
type: UnificationXref
id: H2Q3I0
db: uniprot

uniprot O35904 258
type: UnificationXref
id: O35904
db: uniprot

uniprot Q8BZ03 525
type: UnificationXref
id: Q8BZ03
db: uniprot

PTHR10454:SF157
type: RelationshipXref
id: PTHR10454:SF157
db: PANTHER Family
relationship type: By Homology

GO GO:0005783 3
type: UnificationXref
id: GO:0005783
db: GO

uniprot P27986 266
type: UnificationXref
id: P27986
db: uniprot

uniprot P02511 187
type: UnificationXref
id: P02511
db: uniprot

uniprot F0ZB76 136
type: UnificationXref
id: F0ZB76
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 42
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot D4A5Q1 217
xref: PTHR10048:SF35
organism: Rattus norvegicus

Protein kinase C
type: ProteinReference
xref: PTHR24351:SF182
xref: uniprot F1MDC9 463
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63086 43
organism: Rattus norvegicus

uniprot F7GTQ2 476
type: UnificationXref
id: F7GTQ2
db: uniprot

Serine/threonine-protein kinase D1
type: ProteinReference
xref: PTHR22968:SF9
xref: uniprot Q15139 516
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r46 578
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r46 577
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot P70618 438
type: UnificationXref
id: P70618
db: uniprot

Rho GTPase-activating protein 8
type: ProteinReference
xref: uniprot P85298 412
organism: Homo sapiens

ncbitaxon 6239 158
type: UnificationXref
id: 6239
db: ncbitaxon

Proline-rich protein 5
type: ProteinReference
xref: uniprot P85299 413
organism: Homo sapiens

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A2I3TRY9 209
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__cPLA2-_Ca2_PLUS_-RIGHT__Complex__cPLA2_endsub_Ca2_PLUS__endsuper_-_r71
controller: Erk

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot P15056 348
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r48 573
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

uniprot E2R428 458
type: UnificationXref
id: E2R428
db: uniprot

uniprot E1BMG4 454
type: UnificationXref
id: E1BMG4
db: uniprot

PARTICIPANT STOICHIOMETRY r48 574
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase D2
type: ProteinReference
xref: PTHR22968:SF12
xref: uniprot Q8BZ03 525
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6XP81 101
organism: Xenopus tropicalis

uniprot A8XBU1 389
type: UnificationXref
id: A8XBU1
db: uniprot

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

uniprot Q02111 509
type: UnificationXref
id: Q02111
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F6XMN6 469
xref: PTHR24356:SF170
organism: Canis lupus familiaris

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR10048:SF109
type: RelationshipXref
id: PTHR10048:SF109
db: PANTHER Family
relationship type: By Homology

uniprot F6PX17 314
type: UnificationXref
id: F6PX17
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 332
evidence: Evidence 331
evidence: Evidence 329
evidence: Evidence 330
xref: PTHR44329:SF22
xref: uniprot F7BRK5 339
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q02750 45
organism: Homo sapiens

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot Q7PVR1 95
organism: Anopheles gambiae

uniprot P49138 321
type: UnificationXref
id: P49138
db: uniprot

Ras-like protein rasG
type: ProteinReference
xref: uniprot P15064 156
xref: PTHR24070:SF17
organism: Dictyostelium discoideum

Raf
type: Protein
entity reference: Raf
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot A0A2R8Q8S1 127
xref: PTHR24070:SF388
organism: Danio rerio

GH01042p
type: ProteinReference
xref: uniprot Q8T0V8 372
organism: Drosophila melanogaster

Erk
type: Protein
entity reference: Erk
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q1HG70 47
type: UnificationXref
id: Q1HG70
db: uniprot

Proline-rich protein 5
type: ProteinReference
xref: uniprot Q5FVG6 417
organism: Rattus norvegicus

uniprot F6Y841 235
type: UnificationXref
id: F6Y841
db: uniprot

uniprot P63318 506
type: UnificationXref
id: P63318
db: uniprot

uniprot F1PHV7 142
type: UnificationXref
id: F1PHV7
db: uniprot

PTHR24070:SF17
type: RelationshipXref
id: PTHR24070:SF17
db: PANTHER Family
relationship type: By Homology

uniprot F0ZWE6 140
type: UnificationXref
id: F0ZWE6
db: uniprot

PTHR10048:SF64
type: RelationshipXref
id: PTHR10048:SF64
db: PANTHER Family
relationship type: By Homology

HIF-1
type: Protein
entity reference: HIF-1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAPKAPK2/3
type: ProteinReference
xref: P01415
standard name: Mitogen-activated protein kinase-activated protein kinase 2 and 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.MAPKAPK2/3
comment: ENTITY_REFERENCE_NOTES= Long Name: Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 and 3 Synonym: 3PK,MAPKAP KINASE 2/3,MAPKAP3 Accession: P01415
member entity reference: MAP kinase-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase-activated protein kinase 2
member entity reference: MAPKAPK2 isoform 1
member entity reference: MAP kinase-activated protein kinase 2
member entity reference: AGAP011890-PA (Fragment)
member entity reference: MAPKAPK3 isoform 1
member entity reference: Uncharacterized protein
member entity reference: MAP kinase-activated protein kinase mak-2

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 18

uniprot P11346 346
type: UnificationXref
id: P11346
db: uniprot

uniprot Q2PDT4 365
type: UnificationXref
id: Q2PDT4
db: uniprot

uniprot P09215 493
type: UnificationXref
id: P09215
db: uniprot

uniprot Q9TXI7 291
type: UnificationXref
id: Q9TXI7
db: uniprot

eNOS
type: Protein
entity reference: eNOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa3 543
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot K7BYT0 37
type: UnificationXref
id: K7BYT0
db: uniprot

BAD
type: Protein
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q05655 514
xref: PTHR24356:SF365
organism: Homo sapiens

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 135

INHIBITION
type: RelationshipTypeVocabulary

VEGFR 2 s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VEGFR-2
stoichiometric coefficient: 1.0

uniprot P19174 306
type: UnificationXref
id: P19174
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot E1BWA3 456
xref: PTHR24356:SF214
organism: Gallus gallus

Heat shock protein beta-2
type: ProteinReference
xref: uniprot Q99PR8 200
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r68 554
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: uniprot Q61194 277
xref: PTHR10048:SF28
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r68 553
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

uniprot G5E577 35
type: UnificationXref
id: G5E577
db: uniprot

Serine/threonine-protein kinase D2
type: ProteinReference
xref: PTHR22968:SF12
xref: uniprot Q5XIS9 519
organism: Rattus norvegicus

uniprot G3X7B5 102
type: UnificationXref
id: G3X7B5
db: uniprot

uniprot G5EDY0 246
type: UnificationXref
id: G5EDY0
db: uniprot

GTPase HRas isoform 1
type: ProteinReference
xref: uniprot F7F5K9 145
xref: PTHR24070:SF385
organism: Macaca mulatta

ARHGAP1 isoform 3
type: ProteinReference
xref: uniprot H2Q3I0 405
organism: Pan troglodytes

uniprot P63085 42
type: UnificationXref
id: P63085
db: uniprot

uniprot A0A1D5Q5Z6 25
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

Paxillin
type: Protein
entity reference: Paxillin
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P31938 39
type: UnificationXref
id: P31938
db: uniprot

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

uniprot P60764 409
type: UnificationXref
id: P60764
db: uniprot

uniprot F6V332 434
type: UnificationXref
id: F6V332
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7HLC7 245
xref: PTHR10048:SF35
organism: Macaca mulatta

uniprot F7G3I5 243
type: UnificationXref
id: F7G3I5
db: uniprot

Transforming growth factor beta-1-induced transcript 1 protein
type: ProteinReference
xref: uniprot Q62219 369
organism: Mus musculus

LD28067p
type: ProteinReference
xref: PTHR10048:SF64
xref: uniprot Q7K3H0 282
organism: Drosophila melanogaster

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F1PS03 299
organism: Canis lupus familiaris

uniprot E2RGQ1 390
type: UnificationXref
id: E2RGQ1
db: uniprot

uniprot Q8T0V8 372
type: UnificationXref
id: Q8T0V8
db: uniprot

Protein tyrosine kinase 2
type: ProteinReference
xref: uniprot A0A2I3T3L8 386
xref: PTHR24418:SF78
organism: Pan troglodytes

uniprot Q00944 395
type: UnificationXref
id: Q00944
db: uniprot

Vascular endothelial growth factor receptor 2
type: ProteinReference
xref: uniprot P35918 61
organism: Mus musculus

Caspase-9
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot Q8C3Q9 125
organism: Mus musculus

IDA
type: EvidenceCodeVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot E2RH85 220
organism: Canis lupus familiaris

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot A0A2I3RQJ8 446
organism: Pan troglodytes

uniprot F7ATA8 179
type: UnificationXref
id: F7ATA8
db: uniprot

ncbitaxon 9606 20
type: UnificationXref
id: 9606
db: ncbitaxon

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A3Q1LQK4 211
organism: Bos taurus

uniprot Q61411 167
type: UnificationXref
id: Q61411
db: uniprot

uniprot P28028 349
type: UnificationXref
id: P28028
db: uniprot

uniprot P13677 496
type: UnificationXref
id: P13677
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot G3X7B5 102
xref: PTHR24351:SF200
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 202
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot O02812 436
type: UnificationXref
id: O02812
db: uniprot

PTHR10048:SF48
type: RelationshipXref
id: PTHR10048:SF48
db: PANTHER Family
relationship type: By Homology

uniprot F1MY82 465
type: UnificationXref
id: F1MY82
db: uniprot

PXN isoform 9
type: ProteinReference
xref: uniprot A0A2I3SDP5 355
xref: PTHR24216:SF11
organism: Pan troglodytes

Transforming growth factor beta-1-induced transcript 1 protein
type: ProteinReference
xref: uniprot O43294 361
organism: Homo sapiens

Protein kinase C beta type
type: ProteinReference
xref: uniprot A8KBH6 450
xref: PTHR24356:SF158
organism: Xenopus tropicalis

uniprot F0ZVH9 139
type: UnificationXref
id: F0ZVH9
db: uniprot

uniprot H2QKD0 302
type: UnificationXref
id: H2QKD0
db: uniprot

Evidence 109
type: Evidence
evidence code: ISS
comment: SPACC P50393

uniprot Q9NRA0 71
type: UnificationXref
id: Q9NRA0
db: uniprot

Uncharacterized protein rasB
type: ProteinReference
xref: PTHR24070:SF206
xref: uniprot F0ZI47 138
organism: Dictyostelium purpureum

uniprot A0A2I3SR38 447
type: UnificationXref
id: A0A2I3SR38
db: uniprot

uniprot Q3SYZ2 323
type: UnificationXref
id: Q3SYZ2
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 137

uniprot Q6P023 52
type: UnificationXref
id: Q6P023
db: uniprot

Uncharacterized protein rasG
type: ProteinReference
xref: uniprot F0ZWE6 140
xref: PTHR24070:SF17
organism: Dictyostelium purpureum

uniprot A0A1D5QKD3 26
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

PTHR22968:SF9
type: RelationshipXref
id: PTHR22968:SF9
db: PANTHER Family
relationship type: By Homology

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q503B6 165
organism: Danio rerio

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F1Q3M8 227
organism: Canis lupus familiaris

uniprot P49071 319
type: UnificationXref
id: P49071
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZIF0 48
organism: Gallus gallus

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot H9FVU5 252
organism: Macaca mulatta

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot P36507 41
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot P36506 40
organism: Rattus norvegicus

uniprot A0A2I3T7A8 208
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

uniprot Q8AXB3 65
type: UnificationXref
id: Q8AXB3
db: uniprot

uniprot Q9NP31 76
type: UnificationXref
id: Q9NP31
db: uniprot

uniprot P14602 189
type: UnificationXref
id: P14602
db: uniprot

uniprot Q02750 45
type: UnificationXref
id: Q02750
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot Q7QCP8 524
organism: Anopheles gambiae

Protein kinase C
type: ProteinReference
xref: uniprot F7BYI4 473
xref: PTHR24356:SF158
organism: Macaca mulatta

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

ncbitaxon 7165 96
type: UnificationXref
id: 7165
db: ncbitaxon

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 2

uniprot A0NBA9 213
type: UnificationXref
id: A0NBA9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NW21 58
organism: Gallus gallus

uniprot P47196 105
type: UnificationXref
id: P47196
db: uniprot

PTHR10048:SF29
type: RelationshipXref
id: PTHR10048:SF29
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF28
type: RelationshipXref
id: PTHR10048:SF28
db: PANTHER Family
relationship type: By Homology

Inactive tyrosine-protein kinase kin-32
type: ProteinReference
xref: uniprot Q95YD4 397
organism: Caenorhabditis elegans

uniprot Q5FWK3 418
type: UnificationXref
id: Q5FWK3
db: uniprot

Sck
type: Protein
entity reference: Sck
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR24216:SF11
type: RelationshipXref
id: PTHR24216:SF11
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 214
organism: Rattus norvegicus

PTHR10048:SF30
type: RelationshipXref
id: PTHR10048:SF30
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot F6Y841 235
xref: PTHR10048:SF33
organism: Canis lupus familiaris

uniprot P01111 149
type: UnificationXref
id: P01111
db: uniprot

ncbitaxon 9615 12
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q7PCM8 196
type: UnificationXref
id: Q7PCM8
db: uniprot

Protein tyrosine kinase 2
type: ProteinReference
xref: uniprot F6WLE6 391
xref: PTHR46221:SF5
organism: Monodelphis domestica

Paxillin, isoform F
type: ProteinReference
xref: uniprot Q2PDT4 365
organism: Drosophila melanogaster

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot A0A1D5R8E9 294
organism: Macaca mulatta

uniprot P68404 508
type: UnificationXref
id: P68404
db: uniprot

uniprot Q8MML5 371
type: UnificationXref
id: Q8MML5
db: uniprot

uniprot Q7Q723 197
type: UnificationXref
id: Q7Q723
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70167 260
organism: Mus musculus

uniprot P49147 119
type: UnificationXref
id: P49147
db: uniprot

Heat shock protein beta-2
type: ProteinReference
xref: uniprot O35878 182
organism: Rattus norvegicus

uniprot Q8NEB9 287
type: UnificationXref
id: Q8NEB9
db: uniprot

Akt/PKB
type: ProteinReference
xref: P01408
standard name: protein kinase B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Akt/PKB
comment: ENTITY_REFERENCE_NOTES= Long Name: Thymoma Viral Proto-Oncogene Synonym: Oncogene Akt,PKB,Protein Kinase B,RAC Serine/Threonine Protein Kinase Accession: P01408
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC serine/threonine-protein kinase

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F6TD14 231
organism: Monodelphis domestica

uniprot P70313 430
type: UnificationXref
id: P70313
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot P23726 263
organism: Bos taurus

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P23727 264
organism: Bos taurus

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q63932 50
organism: Mus musculus

uniprot E9I1I7 134
type: UnificationXref
id: E9I1I7
db: uniprot

uniprot P08556 153
type: UnificationXref
id: P08556
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F6TAH0 300
organism: Monodelphis domestica

Sphingosine kinase 2 isoform a
type: ProteinReference
xref: uniprot F6ZFF5 67
organism: Macaca mulatta

Uncharacterized protein rasS
type: ProteinReference
xref: uniprot F0ZVH9 139
xref: PTHR24070:SF380
organism: Dictyostelium purpureum

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot P23928 191
organism: Rattus norvegicus

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot P23927 190
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6SW23 229
organism: Gallus gallus

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: uniprot A0A3Q1LJJ3 378
xref: PTHR11849:SF209
organism: Bos taurus

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70173 261
organism: Rattus norvegicus

uniprot A0A3S5ZPX3 27
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

PARTICIPANT STOICHIOMETRY r53 547
type: Stoichiometry
physical entity: HIF-1
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6RCU6 100
xref: PTHR24356:SF171
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r62 565
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 546
type: Stoichiometry
physical entity: HIF-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r62 566
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r56
control type: ACTIVATION
controller: IP3

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A3Q1MMD9 296
xref: PTHR10336:SF25
organism: Bos taurus

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9258 111
type: UnificationXref
id: 9258
db: ncbitaxon

PLC-gamma
type: Protein
entity reference: PLC-gamma
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E2R2N2 85
type: UnificationXref
id: E2R2N2
db: uniprot

DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r55
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 602
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 600
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 601
left: PIP2
interaction type: DISSOCIATION
right: IP3
right: DAG

uniprot A0A1D5QGM1 425
type: UnificationXref
id: A0A1D5QGM1
db: uniprot

Ras-related C3 botulinum toxin substrate 3
type: ProteinReference
xref: uniprot P60764 409
organism: Mus musculus

Sphingosine kinase 2
type: ProteinReference
xref: uniprot A0A3Q1MBG6 66
organism: Bos taurus

uniprot F1MIA2 464
type: UnificationXref
id: F1MIA2
db: uniprot

uniprot H2QLB4 89
type: UnificationXref
id: H2QLB4
db: uniprot

Ras-related C3 botulinum toxin substrate 3
type: ProteinReference
xref: uniprot P60763 408
organism: Homo sapiens

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: uniprot A0A2I3TF56 377
xref: PTHR11849:SF209
organism: Pan troglodytes

SPK
type: Protein
entity reference: SPK
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q64617 522
type: UnificationXref
id: Q64617
db: uniprot

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot F7FH70 381
organism: Ornithorhynchus anatinus

uniprot Q9VXH3 310
type: UnificationXref
id: Q9VXH3
db: uniprot

uniprot F6W7C8 234
type: UnificationXref
id: F6W7C8
db: uniprot

uniprot Q62074 520
type: UnificationXref
id: Q62074
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 54
organism: Danio rerio

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42336 268
xref: PTHR10048:SF107
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P42338 270
xref: PTHR10048:SF33
organism: Homo sapiens

SPK
type: Protein
entity reference: SPK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42337 269
xref: PTHR10048:SF107
organism: Mus musculus

Phosphatidylinositol 3-kinase age-1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q94125 289
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r71 585
type: Stoichiometry
physical entity: cPLA2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Akt_PKB-RIGHT__Akt_PKB-_r69
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 552
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 551
left: Akt/PKB
interaction type: STATE_TRANSITION
right: Akt/PKB

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 107

uniprot F6S9S9 30
type: UnificationXref
id: F6S9S9
db: uniprot

STATE_TRANSITION_LEFT__cPLA2-_Ca2_PLUS_-RIGHT__Complex__cPLA2_endsub_Ca2_PLUS__endsuper_-_r71
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 587
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 585
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 586
left: cPLA2
left: Ca2+
interaction type: STATE_TRANSITION
right: Complex (cPLA2_endsub/Ca2+_endsuper)

Protein kinase C zeta type
type: ProteinReference
xref: uniprot Q02956 511
xref: PTHR24356:SF170
organism: Mus musculus

ncbitaxon 7719 178
type: UnificationXref
id: 7719
db: ncbitaxon

Alpha b crystallin
type: ProteinReference
xref: uniprot Q9PUR2 201
organism: Danio rerio

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
type: ProteinReference
xref: uniprot Q22070 307
organism: Caenorhabditis elegans

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF9
xref: uniprot A0A3Q1N9F5 449
organism: Bos taurus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q6PF93 281
xref: PTHR10048:SF7
organism: Mus musculus

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot Q64617 522
organism: Rattus norvegicus

uniprot Q5FVG6 417
type: UnificationXref
id: Q5FVG6
db: uniprot

uniprot Q02156 510
type: UnificationXref
id: Q02156
db: uniprot

uniprot Q62600 431
type: UnificationXref
id: Q62600
db: uniprot

uniprot P03967 151
type: UnificationXref
id: P03967
db: uniprot

uniprot F7F3S0 241
type: UnificationXref
id: F7F3S0
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q95ME4 169
xref: PTHR24070:SF189
organism: Monodelphis domestica

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63318 506
organism: Mus musculus

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63319 507
organism: Rattus norvegicus

uniprot F1QNG4 143
type: UnificationXref
id: F1QNG4
db: uniprot

uniprot P01112 150
type: UnificationXref
id: P01112
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot F6W7C8 234
xref: PTHR10048:SF34
organism: Macaca mulatta

uniprot A0A1D5QK16 354
type: UnificationXref
id: A0A1D5QK16
db: uniprot

uniprot O88763 262
type: UnificationXref
id: O88763
db: uniprot

uniprot P42338 270
type: UnificationXref
id: P42338
db: uniprot

Vascular endothelial growth factor A
type: ProteinReference
xref: uniprot P15692 80
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r56 598
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot E2RQM0 298
xref: PTHR10336:SF25
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r56 599
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot A8X0X5 131
type: UnificationXref
id: A8X0X5
db: uniprot

Paxillin
type: ProteinReference
xref: P01418
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Paxillin
comment: ENTITY_REFERENCE_NOTES= Long Name: Paxillin Synonym: PXN Accession: P01418
member entity reference: GH01042p
member entity reference: PXN isoform 9
member entity reference: Transforming growth factor beta 1 induced transcript 1
member entity reference: Paxillin
member entity reference: Leupaxin isoform 2
member entity reference: Protein CBR-PXL-1
member entity reference: LIM domain-containing protein B
member entity reference: Uncharacterized protein
member entity reference: LPXN isoform 3
member entity reference: Paxillin-B
member entity reference: Transforming growth factor beta-1-induced transcript 1 protein
member entity reference: Leupaxin
member entity reference: Paxillin, isoform F

uniprot P08646 155
type: UnificationXref
id: P08646
db: uniprot

Focal adhesion kinase 1
type: ProteinReference
xref: uniprot Q05397 396
xref: PTHR24418:SF78
organism: Homo sapiens

uniprot P54674 273
type: UnificationXref
id: P54674
db: uniprot

PARTICIPANT STOICHIOMETRY r63 563
type: Stoichiometry
physical entity: p38MAPK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 564
type: Stoichiometry
physical entity: p38MAPK
stoichiometric coefficient: 1.0

VRAP
type: ProteinReference
xref: P01405
standard name: VEGFR-Associated Protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.VRAP
comment: ENTITY_REFERENCE_NOTES= Long Name: VEGFR-Associated Protein Synonym: SH2 Domain Protein 2A,SH2D2A,T-Cell SH2 Domain-Containing Adaptor Protein,TSAD Accession: P01405
member entity reference: SH2 domain containing 2A
member entity reference: SH2 domain-containing protein 2A
member entity reference: Uncharacterized protein

uniprot E1C6T4 457
type: UnificationXref
id: E1C6T4
db: uniprot

By Homology
type: RelationshipTypeVocabulary

MEK
type: Protein
entity reference: MEK
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q66JE6 51
organism: Xenopus tropicalis

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 52
organism: Danio rerio

Sphingosine kinase 1
type: ProteinReference
xref: PTHR12358:SF47
xref: uniprot Q9NYA1 72
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r57 597
type: Stoichiometry
physical entity: Complex (VEGFR-2/VEGF)
stoichiometric coefficient: 1.0

ncbitaxon 13616 31
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot A0A2I3RH39 206
type: UnificationXref
id: A0A2I3RH39
db: uniprot

uniprot F7BRK5 339
type: UnificationXref
id: F7BRK5
db: uniprot

uniprot A0A2I3SIY1 207
type: UnificationXref
id: A0A2I3SIY1
db: uniprot

PARTICIPANT STOICHIOMETRY r57 595
type: Stoichiometry
physical entity: VEGFR-2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAPKAPK2_3-RIGHT__MAPKAPK2_3-_r64
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 562
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 561
left: MAPKAPK2/3
interaction type: STATE_TRANSITION
right: MAPKAPK2/3

PARTICIPANT STOICHIOMETRY r57 596
type: Stoichiometry
physical entity: VEGF
stoichiometric coefficient: 1.0

uniprot F7E823 86
type: UnificationXref
id: F7E823
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P23298 500
organism: Mus musculus

uniprot Q07292 351
type: UnificationXref
id: Q07292
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BBM1 237
xref: PTHR10048:SF30
organism: Monodelphis domestica

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 34

uniprot O70173 261
type: UnificationXref
id: O70173
db: uniprot

STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r67
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 555
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 556
left: PIP2
interaction type: STATE_TRANSITION
right: PIP3

Leupaxin
type: ProteinReference
xref: uniprot Q5M852 368
organism: Rattus norvegicus

Ras
type: Protein
entity reference: Ras
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q9XT09 55
organism: Pan troglodytes

uniprot A7STP5 129
type: UnificationXref
id: A7STP5
db: uniprot

uniprot Q6PF93 281
type: UnificationXref
id: Q6PF93
db: uniprot

VRAP
type: Protein
entity reference: VRAP
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q66JE6 51
type: UnificationXref
id: Q66JE6
db: uniprot

Alpha-crystallin A chain
type: ProteinReference
xref: uniprot P68280 194
organism: Canis lupus familiaris

uniprot D4A5Q1 217
type: UnificationXref
id: D4A5Q1
db: uniprot

Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q07960 415
organism: Homo sapiens

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r56
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 599
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 598
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Proline rich 5
type: ProteinReference
xref: uniprot H2QLV6 406
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r71 587
type: Stoichiometry
physical entity: Complex (cPLA2_endsub/Ca2+_endsuper)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 586
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

eNOS s5 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: eNOS
stoichiometric coefficient: 1.0

uniprot F7B727 360
type: UnificationXref
id: F7B727
db: uniprot

uniprot P47712 117
type: UnificationXref
id: P47712
db: uniprot

AGAP011036-PA (Fragment)
type: ProteinReference
xref: PTHR10048:SF64
xref: uniprot A0NBA9 213
organism: Anopheles gambiae

uniprot Q8BTI9 286
type: UnificationXref
id: Q8BTI9
db: uniprot

uniprot P17252 498
type: UnificationXref
id: P17252
db: uniprot

uniprot P05130 491
type: UnificationXref
id: P05130
db: uniprot

uniprot F1NYZ2 28
type: UnificationXref
id: F1NYZ2
db: uniprot

Sphingosine kinase 1
type: ProteinReference
xref: uniprot Q8CI15 69
organism: Mus musculus

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF12
xref: uniprot E2RR18 461
organism: Canis lupus familiaris

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot F6VAQ8 232
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot F7HHY8 316
organism: Macaca mulatta

uniprot A0A1D5R999 170
type: UnificationXref
id: A0A1D5R999
db: uniprot

uniprot F6TAH0 300
type: UnificationXref
id: F6TAH0
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A2I3T7A8 208
organism: Pan troglodytes

Protein kinase C
type: ProteinReference
xref: uniprot E1BMG4 454
xref: PTHR24356:SF181
organism: Bos taurus

uniprot E2RL20 338
type: UnificationXref
id: E2RL20
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P24723 501
organism: Homo sapiens

uniprot F1MYM3 225
type: UnificationXref
id: F1MYM3
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Ca2_PLUS_-_PKC-RIGHT__PKC_Ca2_PLUS_-_re30
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 550
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 548
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 549
left: Ca2+
left: PKC
interaction type: HETERODIMER_ASSOCIATION
right: PKC/Ca2+

uniprot P02504 185
type: UnificationXref
id: P02504
db: uniprot

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot F7BFL2 315
organism: Macaca mulatta

uniprot P08642 154
type: UnificationXref
id: P08642
db: uniprot

PKC/Ca2+
type: Complex
component stoichiometry: PKC s74 a17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s73 a32 STOICHIOMETRY ID COMPLEX
component: Ca2+
component: PKC
feature: COMPLEX BINDING FEATURE s72 csa4 534
feature: COMPLEX BINDING FEATURE s72 csa4 536
cellular location: cytoplasm

MAP2K1 protein
type: ProteinReference
xref: uniprot Q0VD16 46
organism: Bos taurus

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot J9P5W6 36
organism: Canis lupus familiaris

ncbitaxon 9598 16
type: UnificationXref
id: 9598
db: ncbitaxon

Hypoxia inducible factor 1 subunit alpha
type: ProteinReference
xref: PTHR23043:SF7
xref: uniprot F1PZ54 11
organism: Canis lupus familiaris

uniprot Q62101 521
type: UnificationXref
id: Q62101
db: uniprot

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: PTHR23043:SF7
xref: uniprot O35800 17
organism: Rattus norvegicus

uniprot A0A0B4KHC3 444
type: UnificationXref
id: A0A0B4KHC3
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 3

uniprot Q05513 513
type: UnificationXref
id: Q05513
db: uniprot

uniprot Q7KTZ2 283
type: UnificationXref
id: Q7KTZ2
db: uniprot

Phospholipase A2
type: ProteinReference
evidence: Evidence 109
xref: uniprot F6UQ33 112
xref: PTHR10728:SF13
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QYV3 176
organism: Monodelphis domestica

HSPB2 isoform 1
type: ProteinReference
xref: uniprot K7BZ54 181
organism: Pan troglodytes

MAP2K2 isoform 1
type: ProteinReference
xref: uniprot K7BYT0 37
organism: Pan troglodytes

PIK3R1 isoform 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot A0A2I3SIY1 207
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r60 570
type: Stoichiometry
physical entity: Sck
stoichiometric coefficient: 1.0

Nitric oxide synthase, endothelial
type: ProteinReference
xref: uniprot Q62600 431
xref: PTHR19384:SF66
organism: Rattus norvegicus

uniprot F6T0E0 402
type: UnificationXref
id: F6T0E0
db: uniprot

uniprot Q05713 195
type: UnificationXref
id: Q05713
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q02156 510
xref: PTHR24356:SF159
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7FDA0 242
xref: PTHR10048:SF33
organism: Monodelphis domestica

uniprot A0A2I3TF56 377
type: UnificationXref
id: A0A2I3TF56
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot P31938 39
organism: Mus musculus

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

uniprot Q9VTU3 424
type: UnificationXref
id: Q9VTU3
db: uniprot

Serine/threonine-protein kinase D3
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot Q8K1Y2 526
organism: Mus musculus

uniprot P50392 120
type: UnificationXref
id: P50392
db: uniprot

Ets
type: Protein
entity reference: Ets
feature: ACTIVE 24
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q7PMF0 284
organism: Anopheles gambiae

Protein CBR-PXL-1
type: ProteinReference
xref: uniprot A8X7Y4 358
organism: Caenorhabditis briggsae

ncbitaxon 9544 14
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot Q05655 514
type: UnificationXref
id: Q05655
db: uniprot

uniprot F7CBU9 113
type: UnificationXref
id: F7CBU9
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot H2QHR7 483
organism: Pan troglodytes

uniprot P85299 413
type: UnificationXref
id: P85299
db: uniprot

uniprot P10686 304
type: UnificationXref
id: P10686
db: uniprot

PARTICIPANT STOICHIOMETRY r60 569
type: Stoichiometry
physical entity: Sck
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 84
organism: Bos taurus

eNOS
type: Protein
entity reference: eNOS
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31750 104
xref: PTHR24356:SF171
organism: Mus musculus

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 557
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 558
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

PTHR24356:SF240
type: RelationshipXref
id: PTHR24356:SF240
db: PANTHER Family
relationship type: By Homology

uniprot A0A2R8Q8S1 127
type: UnificationXref
id: A0A2R8Q8S1
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 6

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_r65
controller: MAPKAPK2/3

uniprot P02470 183
type: UnificationXref
id: P02470
db: uniprot

uniprot A0A2I3TK00 334
type: UnificationXref
id: A0A2I3TK00
db: uniprot

uniprot Q8CI15 69
type: UnificationXref
id: Q8CI15
db: uniprot

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot P49138 321
xref: PTHR24349:SF63
organism: Mus musculus

uniprot Q61194 277
type: UnificationXref
id: Q61194
db: uniprot

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot P49137 320
xref: PTHR24349:SF63
organism: Homo sapiens

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 111

uniprot F7EEZ1 114
type: UnificationXref
id: F7EEZ1
db: uniprot

uniprot F6QDY0 110
type: UnificationXref
id: F6QDY0
db: uniprot

LIM domain-containing protein B
type: ProteinReference
xref: uniprot Q54NW4 367
organism: Dictyostelium discoideum

uniprot A0A2J8QY32 210
type: UnificationXref
id: A0A2J8QY32
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31749 103
xref: PTHR24356:SF171
organism: Homo sapiens

Evidence 74
type: Evidence
evidence code: ISS
comment: SPACC Q9NP31

uniprot F7F5X1 146
type: UnificationXref
id: F7F5X1
db: uniprot

PARTICIPANT STOICHIOMETRY r66 557
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Akt_PKB-RIGHT__Akt_PKB-_r69
controller: PIP3

PARTICIPANT STOICHIOMETRY r66 558
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

uniprot H2Q845 479
type: UnificationXref
id: H2Q845
db: uniprot

Evidence 77
type: Evidence
evidence code: IDA
comment: SPACC Q9NP31

uniprot A0A2J8L0C8 172
type: UnificationXref
id: A0A2J8L0C8
db: uniprot

uniprot A0A1D5QJY6 205
type: UnificationXref
id: A0A1D5QJY6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F7BVQ1 301
xref: PTHR10336:SF25
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r67
controller: PI3K

ncbitaxon 44689 152
type: UnificationXref
id: 44689
db: ncbitaxon

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P14602 189
organism: Mus musculus

uniprot P14921 382
type: UnificationXref
id: P14921
db: uniprot

Cytosolic phospholipase A2
type: ProteinReference
xref: uniprot P49147 119
xref: PTHR10728:SF13
organism: Gallus gallus

uniprot D3ZVF3 216
type: UnificationXref
id: D3ZVF3
db: uniprot

uniprot A0A2I3TJU8 123
type: UnificationXref
id: A0A2I3TJU8
db: uniprot

uniprot P27577 384
type: UnificationXref
id: P27577
db: uniprot

uniprot A8KBH6 450
type: UnificationXref
id: A8KBH6
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot E1C6T4 457
organism: Gallus gallus

uniprot F6W5V4 403
type: UnificationXref
id: F6W5V4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7E823 86
organism: Monodelphis domestica

uniprot P16885 305
type: UnificationXref
id: P16885
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P08487 303
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_r61
controller: FAK

Ca2 PLUS s6 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3SR38 447
xref: PTHR24356:SF181
organism: Pan troglodytes

PTHR24356:SF214
type: RelationshipXref
id: PTHR24356:SF214
db: PANTHER Family
relationship type: By Homology

uniprot P63086 43
type: UnificationXref
id: P63086
db: uniprot

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot F1PZ82 313
organism: Canis lupus familiaris

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot A0A2I3TK00 334
organism: Pan troglodytes

uniprot O94806 487
type: UnificationXref
id: O94806
db: uniprot

uniprot F6VXG1 233
type: UnificationXref
id: F6VXG1
db: uniprot

Nitric oxide synthase
type: ProteinReference
xref: uniprot A0A3Q1LSD1 426
xref: PTHR19384:SF66
organism: Bos taurus

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 12

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q08BT6 515
xref: PTHR24356:SF159
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QM53 228
xref: PTHR10155:SF2
organism: Ornithorhynchus anatinus

Predicted protein
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot A7STP5 129
organism: Nematostella vectensis

uniprot O43294 361
type: UnificationXref
id: O43294
db: uniprot

uniprot F6RCU6 100
type: UnificationXref
id: F6RCU6
db: uniprot

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa6 533
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

uniprot P04627 342
type: UnificationXref
id: P04627
db: uniprot

RAC serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q8INB9 106
xref: PTHR24356:SF333
organism: Drosophila melanogaster

p38MAPK
type: Protein
entity reference: p38MAPK
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot H2QFS6 250
type: UnificationXref
id: H2QFS6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r54
controller: Erk

uniprot Q5F352 166
type: UnificationXref
id: Q5F352
db: uniprot

Raf
type: ProteinReference
xref: P01417
standard name: Raf Oncogene
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Raf
comment: ENTITY_REFERENCE_NOTES= Long Name: Raf Oncogene Synonym: CRAF,Oncogene MIL,Oncogene Raf1,Transforming Replication-Defective Murine Retrovirus 3611-MSV,v-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 Accession: P01417
member entity reference: Uncharacterized protein
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: Raf homolog serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: Raf homolog serine/threonine-protein kinase Raf
member entity reference: B-Raf proto-oncogene, serine/threonine kinase
member entity reference: A-Raf proto-oncogene, serine/threonine kinase
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase B-raf

uniprot P05625 343
type: UnificationXref
id: P05625
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 10

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q02111 509
xref: PTHR24356:SF181
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r48
controller: Raf

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q5PU49 518
xref: PTHR24356:SF365
organism: Canis lupus familiaris

uniprot Q95ME4 169
type: UnificationXref
id: Q95ME4
db: uniprot

uniprot Q7QCP8 524
type: UnificationXref
id: Q7QCP8
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot H9FU32 340
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F7F5X1 146
organism: Monodelphis domestica

uniprot E1BQN6 455
type: UnificationXref
id: E1BQN6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 33
organism: Xenopus tropicalis

Ets
type: ProteinReference
xref: P01419
standard name: v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1
comment: ENTITY_REFERENCE_NOTES= Long Name: v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1 Synonym: Ets1 Oncogene Accession: P01419
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Ets
member entity reference: ETS proto-oncogene 1, transcription factor
member entity reference: Protein C-ets-1
member entity reference: Uncharacterized protein
member entity reference: LOC100170599 protein

uniprot F6ZFF5 67
type: UnificationXref
id: F6ZFF5
db: uniprot

uniprot Q6AYD8 420
type: UnificationXref
id: Q6AYD8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y6B5 404
organism: Macaca mulatta

Protein kinase C beta type
type: ProteinReference
xref: uniprot P68404 508
xref: PTHR24356:SF158
organism: Mus musculus

uniprot P04049 341
type: UnificationXref
id: P04049
db: uniprot

uniprot H2QPH6 60
type: UnificationXref
id: H2QPH6
db: uniprot

uniprot F6S3S1 427
type: UnificationXref
id: F6S3S1
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot E2RCV1 219
xref: PTHR10048:SF34
organism: Canis lupus familiaris

uniprot A0A2R8RR02 387
type: UnificationXref
id: A0A2R8RR02
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q5F352 166
xref: PTHR24070:SF189
organism: Gallus gallus

uniprot F7BYI4 473
type: UnificationXref
id: F7BYI4
db: uniprot

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

uniprot P48736 271
type: UnificationXref
id: P48736
db: uniprot

uniprot F7FHD1 88
type: UnificationXref
id: F7FHD1
db: uniprot

ACTIVE 24
type: EntityFeature
comment: Active state

STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r62
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 566
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 565
left: FAK
interaction type: STATE_TRANSITION
right: FAK

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P70618 438
xref: PTHR24055:SF110
organism: Rattus norvegicus

uniprot A0A3Q1LTT9 433
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot A0A1D5R999 170
organism: Macaca mulatta

uniprot O46404 259
type: UnificationXref
id: O46404
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F7DVL1 474
organism: Xenopus tropicalis

Protein kinase C
type: ProteinReference
xref: uniprot H2QAS6 481
xref: PTHR24356:SF158
organism: Pan troglodytes

uniprot Q6RUV5 421
type: UnificationXref
id: Q6RUV5
db: uniprot

Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot D4A6C5 400
organism: Rattus norvegicus

uniprot F6XMN6 469
type: UnificationXref
id: F6XMN6
db: uniprot

uniprot Q00731 82
type: UnificationXref
id: Q00731
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot Q9JHG7 290
xref: PTHR10048:SF34
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot E1BQN6 455
organism: Gallus gallus

Sck
type: Protein
entity reference: Sck
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

cPLA2
type: Protein
entity reference: cPLA2
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa5 531
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3TSS9 357
type: UnificationXref
id: A0A2I3TSS9
db: uniprot

uniprot F1PS03 299
type: UnificationXref
id: F1PS03
db: uniprot

uniprot F6XP81 101
type: UnificationXref
id: F6XP81
db: uniprot

HIF1A isoform 7
type: ProteinReference
xref: PTHR23043:SF7
xref: uniprot H2Q8F3 15
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6VXG1 233
xref: PTHR10048:SF107
organism: Xenopus tropicalis

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot H2Q8F2 480
organism: Pan troglodytes

SPK
type: ProteinReference
xref: P01404
standard name: Sphingosine Kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: Sphingosine Kinase Synonym: SPHK Accession: P01404
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.SPK
member entity reference: Sphingosine kinase 1
member entity reference: Sphingosine kinase 2
member entity reference: Sphingosine kinase 2 isoform a
member entity reference: RCG53912, isoform CRA_a

uniprot K7BZ54 181
type: UnificationXref
id: K7BZ54
db: uniprot

uniprot A4GT58 398
type: UnificationXref
id: A4GT58
db: uniprot

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 109
xref: uniprot P47712 117
xref: PTHR10728:SF13
organism: Homo sapiens

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47196 105
xref: PTHR24356:SF171
organism: Rattus norvegicus

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 109
xref: uniprot P47713 118
xref: PTHR10728:SF13
organism: Mus musculus

Paxillin
type: ProteinReference
xref: uniprot F7B727 360
xref: PTHR24216:SF11
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Erk-RIGHT__Erk-_r49
controller: MEK

uniprot H9EU39 484
type: UnificationXref
id: H9EU39
db: uniprot

GO GO:0005737 2
type: UnificationXref
id: GO:0005737
db: GO

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q9TXI7 291
organism: Caenorhabditis elegans

STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_r61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 568
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 567
left: Paxillin
interaction type: STATE_TRANSITION
right: Paxillin

uniprot Q9PUR2 201
type: UnificationXref
id: Q9PUR2
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05771 492
organism: Homo sapiens

Paxillin-B
type: ProteinReference
xref: uniprot Q8MML5 371
xref: PTHR24216:SF58
organism: Dictyostelium discoideum

Sck
type: ProteinReference
xref: P01424
standard name: Shc-Like Protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Sck
comment: ENTITY_REFERENCE_NOTES= Long Name: Shc-Like Protein Synonym: Shc Adaptor Homolog Accession: P01424
member entity reference: SHC-transforming protein 2

Nitric oxide synthase
type: ProteinReference
xref: uniprot A0A1D5QGM1 425
xref: PTHR19384:SF66
organism: Macaca mulatta

uniprot A0A1D5QXL5 376
type: UnificationXref
id: A0A1D5QXL5
db: uniprot

uniprot O73682 79
type: UnificationXref
id: O73682
db: uniprot

Ras
type: ProteinReference
xref: P01411
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Ras
comment: ENTITY_REFERENCE_NOTES= Long Name: Ras Synonym: H-Ras,K-Ras,N-Ras,p21 Accession: P01411
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: NRAS protein
member entity reference: Ras-like protein 1
member entity reference: Uncharacterized protein rasG
member entity reference: GTPase NRas
member entity reference: Uncharacterized protein
member entity reference: GTPase KRas
member entity reference: Ras-like protein rasD
member entity reference: Ras-like protein rasS
member entity reference: Ras-like protein rasB
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: GTPase HRas
member entity reference: Uncharacterized protein rasC
member entity reference: HRAS isoform 2
member entity reference: GTPase HRas isoform 1
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: Ras-like protein rasC
member entity reference: Uncharacterized protein rasB
member entity reference: Ras protein let-60
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: AGAP002219-PA
member entity reference: Predicted protein
member entity reference: NRAS isoform 1
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: Ras-like protein rasG
member entity reference: Uncharacterized protein rasS
member entity reference: Protein CBR-LET-60
member entity reference: Uncharacterized protein rasD

eco ECO:0000270 383
type: UnificationXref
id: ECO:0000270
db: eco

STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 578
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 577
left: Ras
interaction type: STATE_TRANSITION
right: Ras

PANTHER Pathway P00056 1
type: UnificationXref
id: P00056
db: PANTHER Pathway

uniprot P91634 276
type: UnificationXref
id: P91634
db: uniprot

uniprot P42336 268
type: UnificationXref
id: P42336
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A0A1D5R985 445
xref: PTHR24356:SF193
organism: Macaca mulatta

uniprot F1NW21 58
type: UnificationXref
id: F1NW21
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot P01111 149
xref: PTHR24070:SF189
organism: Homo sapiens

uniprot P02489 184
type: UnificationXref
id: P02489
db: uniprot

GTPase HRas
type: ProteinReference
xref: uniprot P01112 150
xref: PTHR24070:SF385
organism: Homo sapiens

Protein kinase C delta type
type: ProteinReference
xref: uniprot P28867 502
xref: PTHR24356:SF365
organism: Mus musculus

Ca2 PLUS s8 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Protein kinase C
type: ProteinReference
xref: uniprot E2RNP2 460
xref: PTHR24356:SF181
organism: Canis lupus familiaris

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

ncbitaxon 45351 130
type: UnificationXref
id: 45351
db: ncbitaxon

Complex (cPLA2_endsub/Ca2+_endsuper)
type: Complex
component stoichiometry: Ca2 PLUS s8 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: cPLA2 s7 sa5 STOICHIOMETRY ID COMPLEX
component: cPLA2
component: Ca2+
feature: COMPLEX BINDING FEATURE s71 a78 530
feature: COMPLEX BINDING FEATURE s71 a78 532
cellular location: cytoplasm

PTHR24418:SF78
type: RelationshipXref
id: PTHR24418:SF78
db: PANTHER Family
relationship type: By Homology

uniprot F6Z5N3 144
type: UnificationXref
id: F6Z5N3
db: uniprot

uniprot P28482 93
type: UnificationXref
id: P28482
db: uniprot

uniprot F7A632 471
type: UnificationXref
id: F7A632
db: uniprot

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

uniprot E2RTE0 359
type: UnificationXref
id: E2RTE0
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 96

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7A632 471
organism: Monodelphis domestica

LOC100170599 protein
type: ProteinReference
xref: uniprot B3DM35 379
xref: PTHR11849:SF209
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F3S0 241
xref: PTHR10048:SF33
organism: Macaca mulatta

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F6Z5N3 144
organism: Monodelphis domestica

AGAP011890-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PZG1 326
organism: Anopheles gambiae

Rho GTPase activating protein 1
type: ProteinReference
xref: uniprot F6W5V4 403
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot A0A1D5QKD3 26
organism: Macaca mulatta

PTHR24070:SF380
type: RelationshipXref
id: PTHR24070:SF380
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__HIF_1-RIGHT__HIF_1-_r53
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 546
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 547
left: HIF-1
interaction type: STATE_TRANSITION
right: HIF-1

ncbitaxon 5786 137
type: UnificationXref
id: 5786
db: ncbitaxon

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot P48736 271
xref: PTHR10048:SF34
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H2PXY8 248
xref: PTHR10048:SF35
organism: Pan troglodytes

Nitric oxide synthase
type: ProteinReference
xref: uniprot H2QVM2 428
xref: PTHR19384:SF66
organism: Pan troglodytes

uniprot F6WLE6 391
type: UnificationXref
id: F6WLE6
db: uniprot

uniprot F7FGD2 475
type: UnificationXref
id: F7FGD2
db: uniprot

uniprot Q9JHK1 126
type: UnificationXref
id: Q9JHK1
db: uniprot

uniprot A0A0G2K5T3 203
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

uniprot Q7QK91 168
type: UnificationXref
id: Q7QK91
db: uniprot

uniprot Q9DGE2 442
type: UnificationXref
id: Q9DGE2
db: uniprot

uniprot Q5ZIF0 48
type: UnificationXref
id: Q5ZIF0
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P27986 266
organism: Homo sapiens

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot P16054 497
xref: PTHR24356:SF159
organism: Mus musculus

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot P27704 38
organism: Rattus norvegicus

uniprot P23726 263
type: UnificationXref
id: P23726
db: uniprot

MAP kinase-activated protein kinase mak-2
type: ProteinReference
xref: uniprot Q965G5 327
organism: Caenorhabditis elegans

uniprot Q7PVR1 95
type: UnificationXref
id: Q7PVR1
db: uniprot

uniprot Q04982 350
type: UnificationXref
id: Q04982
db: uniprot

PTHR19384:SF66
type: RelationshipXref
id: PTHR19384:SF66
db: PANTHER Family
relationship type: By Homology

uniprot P28867 502
type: UnificationXref
id: P28867
db: uniprot

uniprot Q92569 288
type: UnificationXref
id: Q92569
db: uniprot

PI3K
type: Protein
entity reference: PI3K
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PIP2
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Rac family small GTPase 2
type: ProteinReference
xref: uniprot Q5U1Y2 419
organism: Rattus norvegicus

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot E9QAN8 223
organism: Mus musculus

PTHR14388:SF9
type: RelationshipXref
id: PTHR14388:SF9
db: PANTHER Family
relationship type: By Homology

uniprot A0A452DI16 336
type: UnificationXref
id: A0A452DI16
db: uniprot

uniprot P32253 160
type: UnificationXref
id: P32253
db: uniprot

uniprot H9FVU5 252
type: UnificationXref
id: H9FVU5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NCY7 312
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r47 575
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

uniprot A0A1D5R985 445
type: UnificationXref
id: A0A1D5R985
db: uniprot

PARTICIPANT STOICHIOMETRY r47 576
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

Caspase 9, isoform CRA_a
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot Q9JHK1 126
organism: Rattus norvegicus

PTHR10337:SF5
type: RelationshipXref
id: PTHR10337:SF5
db: PANTHER Family
relationship type: By Homology

Rho GTPase Activating protein
type: ProteinReference
xref: uniprot Q23130 416
organism: Caenorhabditis elegans

uniprot F7ATU3 180
type: UnificationXref
id: F7ATU3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7FHD1 88
organism: Monodelphis domestica

uniprot P15153 407
type: UnificationXref
id: P15153
db: uniprot

PIP3
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P26450 265
organism: Mus musculus

STATE_TRANSITION_LEFT__p38MAPK-RIGHT__p38MAPK-_r63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 564
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 563
left: p38MAPK
interaction type: STATE_TRANSITION
right: p38MAPK

uniprot Q61532 49
type: UnificationXref
id: Q61532
db: uniprot

uniprot P11345 345
type: UnificationXref
id: P11345
db: uniprot

uniprot Q63789 279
type: UnificationXref
id: Q63789
db: uniprot

Complex (eNOS/Ca2+_endsuper)
type: Complex
component stoichiometry: eNOS s5 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s6 sa4 STOICHIOMETRY ID COMPLEX
component: Ca2+
component: eNOS
feature: COMPLEX BINDING FEATURE s50 a77 544
feature: COMPLEX BINDING FEATURE s50 a77 542
cellular location: cytoplasm

uniprot A0A3Q1MSP9 448
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

HRAS isoform 2
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot K7ALD7 148
organism: Pan troglodytes

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: uniprot O00443 254
xref: PTHR10048:SF28
organism: Homo sapiens

uniprot A0A2I3RQJ8 446
type: UnificationXref
id: A0A2I3RQJ8
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O02812 436
xref: PTHR24055:SF110
organism: Canis lupus familiaris

ncbitaxon 6238 132
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot F6XT65 32
type: UnificationXref
id: F6XT65
db: uniprot

MAPKAPK2/3
type: Protein
entity reference: MAPKAPK2/3
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P27361 92
type: UnificationXref
id: P27361
db: uniprot

DISSOCIATION
type: InteractionVocabulary

uniprot B3DM35 379
type: UnificationXref
id: B3DM35
db: uniprot

uniprot Q9JIA7 70
type: UnificationXref
id: Q9JIA7
db: uniprot

Serine/threonine-protein kinase D3
type: ProteinReference
xref: uniprot O94806 487
xref: PTHR22968:SF26
organism: Homo sapiens

uniprot Q965G5 327
type: UnificationXref
id: Q965G5
db: uniprot

uniprot O35346 393
type: UnificationXref
id: O35346
db: uniprot

uniprot P09216 494
type: UnificationXref
id: P09216
db: uniprot

PI-3 kinase
type: ProteinReference
xref: uniprot P91634 276
xref: PTHR10048:SF14
organism: Drosophila melanogaster

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 332
xref: PTHR44329:SF22
xref: uniprot Q99N57 352
organism: Mus musculus

Uncharacterized protein rasC
type: ProteinReference
xref: uniprot F1A411 141
xref: PTHR24070:SF251
organism: Dictyostelium purpureum

Erk
type: ProteinReference
xref: P01407
standard name: Extracellular Signal-Regulated Kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Erk
comment: ENTITY_REFERENCE_NOTES= Long Name: Extracellular Signal-Regulated Kinase Synonym: JNK-Activated Kinase1,JNKK1,MAP2K4,MAPK/ERK KINASE 4,MAPKK4,MEK4,MKK4,Mitogen-Activated Protein Kinase Kinase 4,PRKMK4,Protein Kinase, Mitogen-Activated, Kinase 4,SAPK/ERK Kinase 1,SEK1,SERK1 Accession: P01407
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase (Fragment)
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Uncharacterized protein

uniprot F1NJK2 9
type: UnificationXref
id: F1NJK2
db: uniprot

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 20

uniprot F6Y6B5 404
type: UnificationXref
id: F6Y6B5
db: uniprot

uniprot E2RNB6 173
type: UnificationXref
id: E2RNB6
db: uniprot

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r48
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 574
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 573
left: MEK
interaction type: STATE_TRANSITION
right: MEK

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: uniprot F1NJK2 9
organism: Gallus gallus

uniprot F6UQ33 112
type: UnificationXref
id: F6UQ33
db: uniprot

PTHR23043:SF7
type: RelationshipXref
id: PTHR23043:SF7
db: PANTHER Family
relationship type: By Homology

uniprot Q8C3Q9 125
type: UnificationXref
id: Q8C3Q9
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O00459 255
organism: Homo sapiens

uniprot Q16644 322
type: UnificationXref
id: Q16644
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r68
controller: PIP3

uniprot P79737 162
type: UnificationXref
id: P79737
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q61532 49
organism: Mus musculus

uniprot P05129 490
type: UnificationXref
id: P05129
db: uniprot

uniprot P60763 408
type: UnificationXref
id: P60763
db: uniprot

uniprot H2QAS6 481
type: UnificationXref
id: H2QAS6
db: uniprot

Paxillin
type: ProteinReference
xref: uniprot Q66H76 370
xref: PTHR24216:SF11
organism: Rattus norvegicus

uniprot O60711 362
type: UnificationXref
id: O60711
db: uniprot

uniprot F6SZ66 230
type: UnificationXref
id: F6SZ66
db: uniprot

PARTICIPANT STOICHIOMETRY r54 604
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38MAPK-RIGHT__p38MAPK-_r63
controller: Complex (VEGFR-2/VEGF)

PARTICIPANT STOICHIOMETRY r54 603
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

uniprot Q90XF2 527
type: UnificationXref
id: Q90XF2
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q1HG70 47
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r59 592
type: Stoichiometry
physical entity: VRAP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 591
type: Stoichiometry
physical entity: VRAP
stoichiometric coefficient: 1.0

uniprot P32252 159
type: UnificationXref
id: P32252
db: uniprot

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

uniprot P08487 303
type: UnificationXref
id: P08487
db: uniprot

LPXN isoform 3
type: ProteinReference
xref: uniprot A0A2I3TSS9 357
organism: Pan troglodytes

uniprot P63000 410
type: UnificationXref
id: P63000
db: uniprot

PTHR46221:SF5
type: RelationshipXref
id: PTHR46221:SF5
db: PANTHER Family
relationship type: By Homology

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot P08642 154
organism: Gallus gallus

uniprot P42337 269
type: UnificationXref
id: P42337
db: uniprot

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot Q66H84 325
organism: Rattus norvegicus

Vascular endothelial growth factor receptor kdr-like
type: ProteinReference
xref: uniprot Q8AXB3 65
organism: Danio rerio

Raf homolog serine/threonine-protein kinase
type: ProteinReference
xref: PTHR44329:SF193
xref: uniprot Q07292 351
organism: Caenorhabditis elegans

Ras-like protein 1
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P08646 155
organism: Drosophila melanogaster

Akt/PKB
type: Protein
entity reference: Akt/PKB
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P22981 157
type: UnificationXref
id: P22981
db: uniprot

uniprot P85298 412
type: UnificationXref
id: P85298
db: uniprot

uniprot E2RTA9 174
type: UnificationXref
id: E2RTA9
db: uniprot

uniprot Q95NE7 440
type: UnificationXref
id: Q95NE7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6S9S9 30
organism: Monodelphis domestica

SH2 domain-containing protein 2A
type: ProteinReference
evidence: Evidence 77
xref: PTHR14388:SF9
xref: uniprot Q9NP31 76
organism: Homo sapiens

uniprot Q62077 308
type: UnificationXref
id: Q62077
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6V332 434
xref: PTHR24055:SF110
organism: Macaca mulatta

uniprot Q9JHG7 290
type: UnificationXref
id: Q9JHG7
db: uniprot

HIF-1
type: Protein
entity reference: HIF-1
feature: ACTIVE 24
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

VEGF
type: Protein
entity reference: VEGF
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa2 541
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR23043:SF7
xref: uniprot F7HKJ2 13
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot A0A3Q1LTT9 433
organism: Bos taurus

uniprot H9FU32 340
type: UnificationXref
id: H9FU32
db: uniprot

uniprot P23727 264
type: UnificationXref
id: P23727
db: uniprot

uniprot F7HKJ2 13
type: UnificationXref
id: F7HKJ2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot A0A1D5QUZ8 83
organism: Macaca mulatta

uniprot F1Q3M8 227
type: UnificationXref
id: F1Q3M8
db: uniprot

STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r47
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 575
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 576
left: Raf
interaction type: STATE_TRANSITION
right: Raf

uniprot K7CBH8 485
type: UnificationXref
id: K7CBH8
db: uniprot

Leupaxin isoform 2
type: ProteinReference
xref: uniprot A0A1D5Q8X5 353
organism: Macaca mulatta

Serine/threonine-protein kinase dkf-2
type: ProteinReference
xref: uniprot O45818 486
organism: Caenorhabditis elegans

uniprot F7HC75 478
type: UnificationXref
id: F7HC75
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QXL5 376
xref: PTHR11849:SF209
organism: Macaca mulatta

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

uniprot O45818 486
type: UnificationXref
id: O45818
db: uniprot

uniprot D4A6C5 400
type: UnificationXref
id: D4A6C5
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q9WTQ0 529
xref: PTHR24356:SF181
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot P16885 305
xref: PTHR10336:SF25
organism: Homo sapiens

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 152

uniprot F7E313 59
type: UnificationXref
id: F7E313
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot A0A2I3TRY9 209
type: UnificationXref
id: A0A2I3TRY9
db: uniprot

Protein tyrosine kinase 2
type: ProteinReference
xref: uniprot A0A3Q1N508 388
xref: PTHR24418:SF78
organism: Bos taurus

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot F1QNG4 143
organism: Danio rerio

uniprot Q64143 280
type: UnificationXref
id: Q64143
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q05144 414
organism: Mus musculus

Kinase insert domain receptor
type: ProteinReference
xref: uniprot F1MWF1 56
xref: PTHR24416:SF45
organism: Bos taurus

uniprot A0A3Q1M614 311
type: UnificationXref
id: A0A3Q1M614
db: uniprot

uniprot E2RQM0 298
type: UnificationXref
id: E2RQM0
db: uniprot

uniprot A0A3Q1MMD9 296
type: UnificationXref
id: A0A3Q1MMD9
db: uniprot

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot A0A3S5ZPX3 27
organism: Bos taurus

Protein tyrosine kinase 2
type: ProteinReference
xref: uniprot F7CW18 392
xref: PTHR24418:SF78
organism: Xenopus tropicalis

uniprot Q7Q042 523
type: UnificationXref
id: Q7Q042
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot P09217 495
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot P09216 494
xref: PTHR24356:SF159
organism: Rattus norvegicus

uniprot H2Q8F3 15
type: UnificationXref
id: H2Q8F3
db: uniprot

Phosphatidylinositol 3-kinase VPS34-like
type: ProteinReference
xref: uniprot P54676 275
xref: PTHR10048:SF7
organism: Dictyostelium discoideum

Protein kinase C delta type
type: ProteinReference
xref: uniprot P09215 493
xref: PTHR24356:SF365
organism: Rattus norvegicus

uniprot E2RGU7 459
type: UnificationXref
id: E2RGU7
db: uniprot

Rho-GTPase-activating protein 8
type: ProteinReference
xref: uniprot Q6AYD8 420
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MYM3 225
xref: PTHR10048:SF33
organism: Bos taurus

Phosphatidylinositol 3-kinase 3
type: ProteinReference
xref: PTHR10048:SF48
xref: uniprot P54675 274
organism: Dictyostelium discoideum

AGAP007158-PA
type: ProteinReference
xref: uniprot Q7PCM8 196
organism: Anopheles gambiae

Phosphatidylinositol 3-kinase 2
type: ProteinReference
xref: uniprot P54674 273
xref: PTHR10048:SF109
organism: Dictyostelium discoideum

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 130

Phosphatidylinositol 3-kinase 1
type: ProteinReference
xref: uniprot P54673 272
xref: PTHR10048:SF14
organism: Dictyostelium discoideum

uniprot O00750 256
type: UnificationXref
id: O00750
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P10686 304
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r68
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 554
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 553
left: Rac
interaction type: STATE_TRANSITION
right: Rac

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A1D5QLW6 293
xref: PTHR10336:SF25
organism: Macaca mulatta

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P34722 503
xref: PTHR24356:SF347
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y1Z2 380
xref: PTHR11849:SF209
organism: Monodelphis domestica

VEGF s4 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VEGF
stoichiometric coefficient: 1.0

uniprot F7HLC7 245
type: UnificationXref
id: F7HLC7
db: uniprot

uniprot P05771 492
type: UnificationXref
id: P05771
db: uniprot

uniprot Q07960 415
type: UnificationXref
id: Q07960
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q05513 513
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24416:SF45
xref: uniprot F7E313 59
organism: Macaca mulatta

uniprot E1B8P9 84
type: UnificationXref
id: E1B8P9
db: uniprot

uniprot P49024 364
type: UnificationXref
id: P49024
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QLB4 89
xref: PTHR24055:SF203
organism: Pan troglodytes

FAK
type: Protein
entity reference: FAK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot Q04982 350
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r58 594
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r70 588
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot F7H3B3 477
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r58 593
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r70 589
type: Stoichiometry
physical entity: eNOS
stoichiometric coefficient: 1.0

uniprot P32871 267
type: UnificationXref
id: P32871
db: uniprot

uniprot Q5U1Y2 419
type: UnificationXref
id: Q5U1Y2
db: uniprot

IP3
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot E1BMX0 133
type: UnificationXref
id: E1BMX0
db: uniprot

uniprot E9QAN8 223
type: UnificationXref
id: E9QAN8
db: uniprot

Pi3K21B, isoform B
type: ProteinReference
xref: uniprot Q7KTZ2 283
xref: PTHR10155:SF10
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r70 590
type: Stoichiometry
physical entity: Complex (eNOS/Ca2+_endsuper)
stoichiometric coefficient: 1.0

AGAP012252-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q042 523
xref: PTHR24356:SF390
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QJY6 205
xref: PTHR10048:SF28
organism: Macaca mulatta

Protein kinase C delta type
type: ProteinReference
xref: uniprot H9EU39 484
xref: PTHR24356:SF365
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r62
controller: Complex (VEGFR-2/VEGF)

uniprot F6QYV3 176
type: UnificationXref
id: F6QYV3
db: uniprot

uniprot F6TD14 231
type: UnificationXref
id: F6TD14
db: uniprot

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot Q05713 195
organism: Gallus gallus

uniprot P23928 191
type: UnificationXref
id: P23928
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot A0A1D5Q5Z6 25
organism: Macaca mulatta

Alpha-crystallin A chain
type: ProteinReference
xref: uniprot P02489 184
organism: Homo sapiens

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P17252 498
xref: PTHR24356:SF193
organism: Homo sapiens

Caspase9
type: ProteinReference
xref: P01410
standard name: Caspase 9
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Caspase 9 Synonym: APAF3,Apoptotic Protease Activating Factor 3 Accession: P01410
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.Caspase9
member entity reference: Caspase-9
member entity reference: CASP9 isoform 4
member entity reference: Uncharacterized protein
member entity reference: Caspase 9, isoform CRA_a

uniprot A0A2I3THL4 333
type: UnificationXref
id: A0A2I3THL4
db: uniprot

uniprot P24723 501
type: UnificationXref
id: P24723
db: uniprot

RCG53912, isoform CRA_a
type: ProteinReference
xref: uniprot Q6AYB2 68
organism: Rattus norvegicus

uniprot Q5PU49 518
type: UnificationXref
id: Q5PU49
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q9VXH3 310
organism: Drosophila melanogaster

uniprot P31750 104
type: UnificationXref
id: P31750
db: uniprot

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot P28028 349
organism: Mus musculus

uniprot E2RCV1 219
type: UnificationXref
id: E2RCV1
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF9
xref: uniprot F1NHL1 467
organism: Gallus gallus

SHC-transforming protein 2
type: ProteinReference
xref: PTHR10337:SF5
xref: uniprot P98077 443
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r55
controller: PLC-gamma

PLC-gamma
type: ProteinReference
xref: P01414
standard name: Phospholipase C-gamma
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.PLC-_gamma_
comment: ENTITY_REFERENCE_NOTES= Long Name: Phospholipase C-gamma Synonym: PHOSPHOLIPASE C-148,PLC1,PLC148,PLCG1 Accession: P01414
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

STATE_TRANSITION
type: InteractionVocabulary

Kinase insert domain receptor
type: ProteinReference
xref: PTHR24416:SF45
xref: uniprot Q2XPT7 64
organism: Canis lupus familiaris

uniprot F7BZL6 238
type: UnificationXref
id: F7BZL6
db: uniprot

TRANSPORT
type: InteractionVocabulary

uniprot F7DUD6 239
type: UnificationXref
id: F7DUD6
db: uniprot

Raf
type: Protein
entity reference: Raf
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q28EW2 164
organism: Xenopus tropicalis

ncbitaxon 10090 23
type: UnificationXref
id: 10090
db: ncbitaxon

Protein C-ets-1
type: ProteinReference
xref: uniprot P41156 385
xref: PTHR11849:SF209
organism: Rattus norvegicus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q16539 439
xref: PTHR24055:SF110
organism: Homo sapiens

PKC
type: ProteinReference
xref: P01425
standard name: Protein kinase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.PKC
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein Kinase C Synonym: Synonym not specified Accession: P01425
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C-like 1
member entity reference: Serine/threonine-protein kinase
member entity reference: Protein kinase C gamma type (Fragment)
member entity reference: Serine/threonine-protein kinase D1
member entity reference: Protein kinase C
member entity reference: AGAP012252-PA (Fragment)
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C eta type
member entity reference: Serine/threonine-protein kinase D2
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C zeta type
member entity reference: Protein kinase C theta type
member entity reference: Protein kinase C iota type
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C-like 1B
member entity reference: Protein kinase C-like 3
member entity reference: Serine/threonine-protein kinase dkf-2
member entity reference: Protein kinase C, brain isozyme
member entity reference: Serine/threonine-protein kinase D3
member entity reference: Protein kinase C, eye isozyme

uniprot Q63932 50
type: UnificationXref
id: Q63932
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot E9I1I7 134
organism: Daphnia pulex

Vascular endothelial growth factor A
type: ProteinReference
xref: uniprot P67964 81
organism: Gallus gallus

VEGF
type: ProteinReference
xref: P01406
standard name: Vascular Endothelial Growth Factor
comment: ENTITY_REFERENCE_NOTES= Long Name: Vascular Endothelial Growth Factor Synonym: VEGF-A Accession: P01406
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.VEGF
member entity reference: Vascular endothelial growth factor A
member entity reference: Vascular endothelial growth factor A-A

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot Q8CIH5 309
xref: PTHR10336:SF25
organism: Mus musculus

uniprot A0A1D5QK27 122
type: UnificationXref
id: A0A1D5QK27
db: uniprot

Alpha-crystallin A chain
type: ProteinReference
xref: uniprot P02470 183
organism: Bos taurus

eNOS
type: ProteinReference
xref: P01422
standard name: endothelial nitric oxide synthase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.eNOS
comment: ENTITY_REFERENCE_NOTES= Long Name: endothelial nitric oxide synthase Synonym: NOS3,Nitric Oxide Synthase 3,eNOS Accession: P01422
member entity reference: Nitric oxide synthase
member entity reference: Nitric oxide synthase, endothelial

uniprot A0A2I3SRD0 356
type: UnificationXref
id: A0A2I3SRD0
db: uniprot

uniprot F1Q2Q9 226
type: UnificationXref
id: F1Q2Q9
db: uniprot

PTHR10155:SF10
type: RelationshipXref
id: PTHR10155:SF10
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

uniprot F7CW18 392
type: UnificationXref
id: F7CW18
db: uniprot

Phospholipase A2
type: ProteinReference
xref: PTHR10728:SF32
xref: uniprot F7HAF3 115
organism: Macaca mulatta

AGAP005548-PA
type: ProteinReference
xref: uniprot Q7Q723 197
organism: Anopheles gambiae

uniprot Q22070 307
type: UnificationXref
id: Q22070
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RJX4 98
xref: PTHR24356:SF171
organism: Canis lupus familiaris

AGAP005547-PA
type: ProteinReference
xref: uniprot Q7Q724 198
organism: Anopheles gambiae

Serine/threonine-protein kinase D1
type: ProteinReference
xref: PTHR22968:SF9
xref: uniprot Q62101 521
organism: Mus musculus

Caspase9
type: Protein
entity reference: Caspase9
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re30 550
type: Stoichiometry
physical entity: PKC/Ca2+
stoichiometric coefficient: 1.0

uniprot Q6AYB2 68
type: UnificationXref
id: Q6AYB2
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF9
xref: uniprot H2Q845 479
organism: Pan troglodytes

uniprot P55211 124
type: UnificationXref
id: P55211
db: uniprot

uniprot E2RIF9 221
type: UnificationXref
id: E2RIF9
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot H2QNG6 251
xref: PTHR10048:SF33
organism: Pan troglodytes

PKC s74 a17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F7BZL6 238
organism: Macaca mulatta

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase9-RIGHT__Caspase9-_re28
control type: INHIBITION
controller: Akt/PKB

Paxillin
type: ProteinReference
xref: uniprot Q8VI36 373
xref: PTHR24216:SF11
organism: Mus musculus

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 21

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot O46404 259
xref: PTHR10155:SF2
organism: Bos taurus

uniprot F0ZI47 138
type: UnificationXref
id: F0ZI47
db: uniprot

uniprot F7GAP5 244
type: UnificationXref
id: F7GAP5
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q04759 512
xref: PTHR24356:SF181
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot A0A3Q1MSP9 448
organism: Bos taurus

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot A0A0B4KHC3 444
organism: Drosophila melanogaster

uniprot Q66H76 370
type: UnificationXref
id: Q66H76
db: uniprot

PARTICIPANT STOICHIOMETRY r61 568
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r61 567
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 548
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 549
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 74
xref: PTHR14388:SF9
xref: uniprot A0A1D5QZZ0 73
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r49 572
type: Stoichiometry
physical entity: Erk
stoichiometric coefficient: 1.0

uniprot A0A3Q2U4X3 97
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

PIK3CG isoform 1
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot A0A2J8QY32 210
organism: Pan troglodytes

cPLA2
type: ProteinReference
xref: P01409
standard name: Cytoplasmic Phospholipase A2
comment: ENTITY_REFERENCE_ID_DESC=VEGF signaling pathway.PROTEIN.GENERIC.cPLA_sub_2_endsub
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Cytoplasmic Phospholipase A2 Synonym: CPLA2,PLA2 Accession: P01409
member entity reference: Phospholipase A2
member entity reference: Cytosolic phospholipase A2

STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 581
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 582
left: BAD
interaction type: STATE_TRANSITION
right: BAD

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__VRAP-RIGHT__VRAP-_r59
controller: Complex (VEGFR-2/VEGF)

Paxillin
type: Protein
entity reference: Paxillin
feature: ACTIVE 24
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P98077 443
type: UnificationXref
id: P98077
db: uniprot

PARTICIPANT STOICHIOMETRY r49 571
type: Stoichiometry
physical entity: Erk
stoichiometric coefficient: 1.0