Dihydroxy isovalerate reductoisomerase
type: ProteinReference
xref: P03217
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydroxy isovalerate reductoisomerase Synonym: Synonym not specified Accession: P03217
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Valine biosynthesis.PROTEIN.GENERIC.Dihydroxy isovalerate_br_reductoisomerase
member entity reference: Ketol-acid reductoisomerase (NADP(+))
member entity reference: Ketol-acid reductoisomerase, chloroplastic
member entity reference: Ketol-acid reductoisomerase (NADP(+)) 1
member entity reference: Ketol-acid reductoisomerase, mitochondrial
member entity reference: Ketol-acid reductoisomerase (NADP(+)) 2
member entity reference: Probable ketol-acid reductoisomerase, mitochondrial

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot F1PY28 10
organism: Canis lupus familiaris

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 55

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A0A2I3RE03 4
organism: Pan troglodytes

Dihydroxy-acid dehydratase, mitochondrial
type: ProteinReference
xref: uniprot P39522 125
organism: Saccharomyces cerevisiae

uniprot A0A1D5Q6Y3 2
type: UnificationXref
id: A0A1D5Q6Y3
db: uniprot

uniprot Q6K2E8 90
type: UnificationXref
id: Q6K2E8
db: uniprot

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 112

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A0A3Q1ML78 6
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r2 149
type: Stoichiometry
physical entity: 2-acetolactate
stoichiometric coefficient: 1.0

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 49

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O86428 24
type: UnificationXref
id: O86428
db: uniprot

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 89

Methionine aminotransferase BCAT4
type: ProteinReference
xref: uniprot Q9LE06 56
organism: Arabidopsis thaliana

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q7SBQ5 131
organism: Neurospora crassa

uniprot Q5EA40 45
type: UnificationXref
id: Q5EA40
db: uniprot

ncbitaxon 9544 3
type: UnificationXref
id: 9544
db: ncbitaxon

ncbitaxon 39947 47
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q8TJJ4 117
type: UnificationXref
id: Q8TJJ4
db: uniprot

uniprot P9WG41 84
type: UnificationXref
id: P9WG41
db: uniprot

Dihydroxy-acid dehydratase, chloroplastic
type: ProteinReference
xref: uniprot Q9LIR4 138
organism: Arabidopsis thaliana

uniprot P37251 82
type: UnificationXref
id: P37251
db: uniprot

uniprot P39358 124
type: UnificationXref
id: P39358
db: uniprot

Acetolactate synthase
type: ProteinReference
xref: uniprot Q8TPF5 93
organism: Methanosarcina acetivorans

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 103

uniprot Q8ZTD9 95
type: UnificationXref
id: Q8ZTD9
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9XXD8 65
organism: Caenorhabditis elegans

uniprot Q8TR30 94
type: UnificationXref
id: Q8TR30
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 21

uniprot P08142 77
type: UnificationXref
id: P08142
db: uniprot

Branched-chain-amino-acid transaminase 1
type: ProteinReference
xref: uniprot O31461 16
organism: Bacillus subtilis

uniprot Q7NH80 111
type: UnificationXref
id: Q7NH80
db: uniprot

Putative branched-chain-amino-acid aminotransferase 7
type: ProteinReference
xref: uniprot Q9LPM8 58
organism: Arabidopsis thaliana

uniprot P9WQ75 39
type: UnificationXref
id: P9WQ75
db: uniprot

Branched-chain-amino-acid aminotransferase 6
type: ProteinReference
xref: uniprot Q9LPM9 59
organism: Arabidopsis thaliana

uniprot O61856 74
type: UnificationXref
id: O61856
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q7QEI9 48
organism: Anopheles gambiae

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 30

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 38

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot O35855 20
organism: Mus musculus

Putative dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q9X9Y4 142
organism: Streptomyces coelicolor

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 64

Acetolactate synthase-like protein
type: ProteinReference
xref: uniprot A6QQT9 67
organism: Bos taurus

Ketol-acid reductoisomerase, mitochondrial
type: ProteinReference
xref: uniprot P06168 106
organism: Saccharomyces cerevisiae

Probable branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot O67733 22
organism: Aquifex aeolicus

P03215
type: UnificationXref
id: P03215
db: PANTHER Pathway Component

Acetolactate synthase
type: ProteinReference
xref: uniprot O66759 75
organism: Aquifex aeolicus

uniprot Q8ZTE2 52
type: UnificationXref
id: Q8ZTE2
db: uniprot

uniprot O31461 16
type: UnificationXref
id: O31461
db: uniprot

Dihydroxy isovalerate dehydratase
type: ProteinReference
xref: P03218
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydroxy isovalerate dehydratase Synonym: Synonym not specified Accession: P03218
comment: ENTITY_REFERENCE_ID_DESC=Valine biosynthesis.PROTEIN.GENERIC.Dihydroxy isovalerate_br_dehydratase
member entity reference: Dihydroxy-acid dehydratase
member entity reference: D-xylonate dehydratase YjhG
member entity reference: Putative dihydroxy-acid dehydratase, mitochondrial
member entity reference: Dihydroxy-acid dehydratase, chloroplastic
member entity reference: D-xylonate dehydratase YagF
member entity reference: Putative dihydroxy-acid dehydratase
member entity reference: Dihydroxy-acid dehydratase, mitochondrial
member entity reference: Dihydroxy-acid dehydratase 1
member entity reference: Dihydroxy-acid dehydratase 2

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot Q5EA40 45
organism: Bos taurus

uniprot P39576 31
type: UnificationXref
id: P39576
db: uniprot

ncbitaxon 9606 15
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot P77596 127
type: UnificationXref
id: P77596
db: uniprot

Branched chain amino acid aminotransferase
type: Protein
entity reference: Branched chain amino acid aminotransferase
comment: SPECIES_TYPE=PROTEIN

Acetolactate synthase-like protein
type: ProteinReference
xref: uniprot A1L0T0 66
organism: Homo sapiens

uniprot O67733 22
type: UnificationXref
id: O67733
db: uniprot

uniprot Q10318 128
type: UnificationXref
id: Q10318
db: uniprot

ncbitaxon 10090 21
type: UnificationXref
id: 10090
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2_acetolactate-_NADPH-RIGHT__2,3_dihydroxy_isovalerate-_NADP-_r2
controller: Dihydroxy isovalerate reductoisomerase

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 42

uniprot Q9Z565 121
type: UnificationXref
id: Q9Z565
db: uniprot

uniprot Q58414 43
type: UnificationXref
id: Q58414
db: uniprot

Acetolactate synthase large subunit IlvG
type: ProteinReference
xref: uniprot P9WG39 83
organism: Mycobacterium tuberculosis

uniprot Q57725 86
type: UnificationXref
id: Q57725
db: uniprot

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 116

Branched chain amino acid aminotransferase
type: ProteinReference
xref: P03215
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Valine biosynthesis.PROTEIN.GENERIC.Branched chain_br_amino acid_br_aminotransferase
comment: ENTITY_REFERENCE_NOTES= Long Name: Branched chain amino acid aminotransferase Synonym: Synonym not specified Accession: P03215
member entity reference: Branched-chain-amino-acid aminotransferase
member entity reference: Putative branched-chain-amino-acid aminotransferase 7
member entity reference: Methionine aminotransferase BCAT4
member entity reference: Probable branched-chain-amino-acid aminotransferase
member entity reference: Branched-chain-amino-acid aminotransferase, cytosolic
member entity reference: Branched-chain-amino-acid aminotransferase 6
member entity reference: Branched-chain-amino-acid aminotransferase, mitochondrial
member entity reference: Branched-chain-amino-acid aminotransferase 3, chloroplastic
member entity reference: Putative branched-chain-amino-acid aminotransferase
member entity reference: Branched-chain-amino-acid transaminase 1
member entity reference: Branched-chain-amino-acid aminotransferase 2

uniprot O06335 73
type: UnificationXref
id: O06335
db: uniprot

Acetolactate synthase
type: ProteinReference
xref: uniprot Q9HVA0 97
organism: Pseudomonas aeruginosa

uniprot Q9XXD8 65
type: UnificationXref
id: Q9XXD8
db: uniprot

Acetolactate synthase isozyme 1 large subunit
type: ProteinReference
xref: uniprot P08142 77
organism: Escherichia coli

Ketol-acid reductoisomerase, mitochondrial
type: ProteinReference
xref: uniprot P38674 108
organism: Neurospora crassa

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot O35854 18
organism: Rattus norvegicus

uniprot Q9HWK1 98
type: UnificationXref
id: Q9HWK1
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 81

Acetolactate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q5KPJ5 88
organism: Cryptococcus neoformans

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot H2QGS7 13
organism: Pan troglodytes

Putative acetolactate synthase large subunit IlvB2
type: ProteinReference
xref: uniprot O06335 73
organism: Mycobacterium tuberculosis

uniprot P51785 126
type: UnificationXref
id: P51785
db: uniprot

uniprot F6ZG49 12
type: UnificationXref
id: F6ZG49
db: uniprot

ncbitaxon 83332 40
type: UnificationXref
id: 83332
db: ncbitaxon

Acetolactate synthase-like protein
type: ProteinReference
xref: uniprot F6YYE8 71
organism: Macaca mulatta

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot O86428 24
organism: Pseudomonas aeruginosa

uniprot O66759 75
type: UnificationXref
id: O66759
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 5

uniprot Q9RDF9 100
type: UnificationXref
id: Q9RDF9
db: uniprot

ncbitaxon 214684 89
type: UnificationXref
id: 214684
db: ncbitaxon

Acetolactate synthase 1, chloroplastic
type: ProteinReference
xref: uniprot Q6K2E8 90
organism: Oryza sativa

ncbitaxon 6238 9
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot Q04789 85
type: UnificationXref
id: Q04789
db: uniprot

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q7NH80 111
organism: Gloeobacter violaceus

Putative acetolactate synthase
type: ProteinReference
xref: uniprot Q9RDF9 100
organism: Streptomyces coelicolor

uniprot P07342 76
type: UnificationXref
id: P07342
db: uniprot

uniprot H2QGS7 13
type: UnificationXref
id: H2QGS7
db: uniprot

ncbitaxon 1111708 38
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot P24288 28
type: UnificationXref
id: P24288
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot O69198 123
organism: Streptomyces coelicolor

ncbitaxon 226186 116
type: UnificationXref
id: 226186
db: ncbitaxon

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot P9WQ75 39
organism: Mycobacterium tuberculosis

ncbitaxon 9913 7
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot Q8TI08 50
type: UnificationXref
id: Q8TI08
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q1K779 41
organism: Neurospora crassa

uniprot P54690 36
type: UnificationXref
id: P54690
db: uniprot

Probable ketol-acid reductoisomerase, mitochondrial
type: ProteinReference
xref: uniprot P78827 109
organism: Schizosaccharomyces pombe

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot P37253 107
organism: Bacillus subtilis

Acetolactate synthase, chloroplastic
type: ProteinReference
xref: uniprot P17597 79
organism: Arabidopsis thaliana

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9VYD5 63
organism: Drosophila melanogaster

ncbitaxon 208964 25
type: UnificationXref
id: 208964
db: ncbitaxon

ncbitaxon 284812 81
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot O67289 105
type: UnificationXref
id: O67289
db: uniprot

Branched-chain-amino-acid aminotransferase 2
type: ProteinReference
xref: uniprot P39576 31
organism: Bacillus subtilis

Acetolactate synthase large subunit
type: ProteinReference
xref: uniprot P37251 82
organism: Bacillus subtilis

Acetolactate synthase
type: ProteinReference
xref: uniprot Q8TJJ2 92
organism: Methanosarcina acetivorans

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 135

ncbitaxon 243274 103
type: UnificationXref
id: 243274
db: ncbitaxon

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot P51785 126
organism: Bacillus subtilis

Acetolactate synthase
type: Protein
entity reference: Acetolactate synthase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 559292 30
type: UnificationXref
id: 559292
db: ncbitaxon

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 62

ncbitaxon 189518 135
type: UnificationXref
id: 189518
db: ncbitaxon

D-xylonate dehydratase YagF
type: ProteinReference
xref: uniprot P77596 127
organism: Escherichia coli

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 15

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 44

uniprot Q8BU33 91
type: UnificationXref
id: Q8BU33
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A0A1D5Q6Y3 2
organism: Macaca mulatta

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 251221 112
type: UnificationXref
id: 251221
db: ncbitaxon

uniprot Q9LIR4 138
type: UnificationXref
id: Q9LIR4
db: uniprot

IlvB acetolactate synthase like
type: ProteinReference
xref: uniprot F1Q255 70
organism: Canis lupus familiaris

ncbitaxon 6239 35
type: UnificationXref
id: 6239
db: ncbitaxon

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 57

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9RTX5 61
organism: Deinococcus radiodurans

uniprot A8WUX0 68
type: UnificationXref
id: A8WUX0
db: uniprot

ncbitaxon 9598 5
type: UnificationXref
id: 9598
db: ncbitaxon

Acetolactate synthase
type: ProteinReference
xref: uniprot Q8ZTD9 95
organism: Pyrobaculum aerophilum

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9HNF8 54
organism: Halobacterium salinarum

PANTHER Pathway P02785 1
type: UnificationXref
id: P02785
db: PANTHER Pathway

uniprot Q9VYD5 63
type: UnificationXref
id: Q9VYD5
db: uniprot

uniprot Q9WZ18 102
type: UnificationXref
id: Q9WZ18
db: uniprot

ILVBL isoform 1
type: ProteinReference
xref: uniprot H2QFL7 72
organism: Pan troglodytes

Probable 2-ketoarginine decarboxylase AruI
type: ProteinReference
xref: uniprot Q9HUI8 96
organism: Pseudomonas aeruginosa

ncbitaxon 224308 17
type: UnificationXref
id: 224308
db: ncbitaxon

Acetolactate synthase-like protein
type: ProteinReference
xref: uniprot Q8BU33 91
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r4 156
type: Stoichiometry
physical entity: valine
stoichiometric coefficient: 1.0

uniprot Q9LPM8 58
type: UnificationXref
id: Q9LPM8
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 40

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 188937 51
type: UnificationXref
id: 188937
db: ncbitaxon

ncbitaxon 3702 57
type: UnificationXref
id: 3702
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r4 153
type: Stoichiometry
physical entity: 2 ketoisovalerate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 154
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 155
type: Stoichiometry
physical entity: ketoglutarate
stoichiometric coefficient: 1.0

uniprot O35854 18
type: UnificationXref
id: O35854
db: uniprot

uniprot Q7QEI9 48
type: UnificationXref
id: Q7QEI9
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__pyruvate-RIGHT__2_acetolactate-_CO2-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 144
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 145
left: pyruvate
interaction type: HETERODIMER_ASSOCIATION
right: CO2
right: 2-acetolactate

uniprot A8WM75 8
type: UnificationXref
id: A8WM75
db: uniprot

uniprot Q1K779 41
type: UnificationXref
id: Q1K779
db: uniprot

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 78

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot F6ZG49 12
organism: Macaca mulatta

uniprot P38674 108
type: UnificationXref
id: P38674
db: uniprot

ncbitaxon 83333 78
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot P06168 106
type: UnificationXref
id: P06168
db: uniprot

uniprot Q7NGK1 130
type: UnificationXref
id: Q7NGK1
db: uniprot

Branched-chain-amino-acid aminotransferase 3, chloroplastic
type: ProteinReference
xref: uniprot Q9M401 60
organism: Arabidopsis thaliana

ncbitaxon 7227 64
type: UnificationXref
id: 7227
db: ncbitaxon

Acetolactate synthase, large subunit
type: ProteinReference
xref: uniprot Q8TR30 94
organism: Methanosarcina acetivorans

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q8ZTE2 52
organism: Pyrobaculum aerophilum

uniprot Q8TJJ2 92
type: UnificationXref
id: Q8TJJ2
db: uniprot

uniprot Q9WZ21 141
type: UnificationXref
id: Q9WZ21
db: uniprot

uniprot Q9HNF8 54
type: UnificationXref
id: Q9HNF8
db: uniprot

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P54690 36
organism: Rattus norvegicus

Dihydroxy isovalerate reductoisomerase
type: Protein
entity reference: Dihydroxy isovalerate reductoisomerase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 64091 55
type: UnificationXref
id: 64091
db: ncbitaxon

uniprot Q9RJZ4 139
type: UnificationXref
id: Q9RJZ4
db: uniprot

Probable branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot P54691 37
organism: Synechocystis

Putative dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q9RJZ4 139
organism: Streptomyces coelicolor

uniprot Q7UJ69 132
type: UnificationXref
id: Q7UJ69
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2,3_dihydroxy_isovalerate-RIGHT__2_ketoisovalerate-_H2O-_r3
controller: Dihydroxy isovalerate dehydratase

Ketol-acid reductoisomerase (NADP(+)) 1
type: ProteinReference
xref: uniprot Q9Z565 121
organism: Streptomyces coelicolor

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P54688 34
organism: Caenorhabditis elegans

Acetolactate synthase
type: ProteinReference
xref: uniprot Q9Z567 104
organism: Streptomyces coelicolor

uniprot Q8TKM8 136
type: UnificationXref
id: Q8TKM8
db: uniprot

STATE_TRANSITION_LEFT__2,3_dihydroxy_isovalerate-RIGHT__2_ketoisovalerate-_H2O-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 147
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 146
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 148
left: 2,3-dihydroxy isovalerate
interaction type: STATE_TRANSITION
right: H2O
right: 2 ketoisovalerate

uniprot F6YYE8 71
type: UnificationXref
id: F6YYE8
db: uniprot

uniprot Q8A608 133
type: UnificationXref
id: Q8A608
db: uniprot

2 ketoisovalerate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 243090 114
type: UnificationXref
id: 243090
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re5 144
type: Stoichiometry
physical entity: 2-acetolactate
stoichiometric coefficient: 1.0

Acetolactate synthase
type: ProteinReference
xref: uniprot Q9WZ18 102
organism: Thermotoga maritima

STATE_TRANSITION_LEFT__2_ketoisovalerate-_glutamate-RIGHT__ketoglutarate-_valine-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 154
left: glutamate
left: 2 ketoisovalerate
interaction type: STATE_TRANSITION
right: valine
right: ketoglutarate

PARTICIPANT STOICHIOMETRY re5 143
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 17

PARTICIPANT STOICHIOMETRY re5 145
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

2,3-dihydroxy isovalerate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F1Q255 70
type: UnificationXref
id: F1Q255
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 7

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot H2QFL7 72
type: UnificationXref
id: H2QFL7
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q7NGK1 130
organism: Gloeobacter violaceus

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot O15382 14
organism: Homo sapiens

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 3

Probable branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot O86505 26
organism: Streptomyces coelicolor

Dihydroxy isovalerate dehydratase
type: Protein
entity reference: Dihydroxy isovalerate dehydratase
comment: SPECIES_TYPE=PROTEIN

Probable decarboxylase
type: ProteinReference
xref: uniprot Q9I280 99
organism: Pseudomonas aeruginosa

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P47176 32
organism: Saccharomyces cerevisiae

uniprot A0A2I3RE03 4
type: UnificationXref
id: A0A2I3RE03
db: uniprot

uniprot P38891 29
type: UnificationXref
id: P38891
db: uniprot

uniprot Q9I280 99
type: UnificationXref
id: Q9I280
db: uniprot

Valine biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__2,3_dihydroxy_isovalerate-RIGHT__2_ketoisovalerate-_H2O-_r3
pathway component: STATE_TRANSITION_LEFT__2_acetolactate-_NADPH-RIGHT__2,3_dihydroxy_isovalerate-_NADP-_r2
pathway component: STATE_TRANSITION_LEFT__2_ketoisovalerate-_glutamate-RIGHT__ketoglutarate-_valine-_r4
pathway component: HETERODIMER_ASSOCIATION_LEFT__pyruvate-RIGHT__2_acetolactate-_CO2-_re5
xref: PANTHER Pathway P02785 1
comment: MODEL_NOTES= The biosynthesis of the amino acid valine critical to protein biosynthesis. Website=www.biocyc.org/Ecoli/Pathways/ free text=References

uniprot O35855 20
type: UnificationXref
id: O35855
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q9RV97 140
organism: Deinococcus radiodurans

uniprot A1L0T0 66
type: UnificationXref
id: A1L0T0
db: uniprot

Uncharacterized protein MJ0663
type: ProteinReference
xref: uniprot Q58077 87
organism: Methanocaldococcus jannaschii

uniprot Q9RV97 140
type: UnificationXref
id: Q9RV97
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot O67009 122
organism: Aquifex aeolicus

uniprot Q58077 87
type: UnificationXref
id: Q58077
db: uniprot

uniprot P54691 37
type: UnificationXref
id: P54691
db: uniprot

uniprot Q9WZ20 120
type: UnificationXref
id: Q9WZ20
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q8F219 134
organism: Leptospira interrogans

pyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 51

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q9WZ21 141
organism: Thermotoga maritima

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q9WZ20 120
organism: Thermotoga maritima

uniprot Q1K658 129
type: UnificationXref
id: Q1K658
db: uniprot

D-xylonate dehydratase YjhG
type: ProteinReference
xref: uniprot P39358 124
organism: Escherichia coli

Acetolactate synthase catalytic subunit, mitochondrial
type: ProteinReference
xref: uniprot P07342 76
organism: Saccharomyces cerevisiae

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot O67289 105
organism: Aquifex aeolicus

uniprot P17597 79
type: UnificationXref
id: P17597
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q1K658 129
organism: Neurospora crassa

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 19

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 23

Putative dihydroxy-acid dehydratase, mitochondrial
type: ProteinReference
xref: uniprot Q10318 128
organism: Schizosaccharomyces pombe

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 11

uniprot Q9M401 60
type: UnificationXref
id: Q9M401
db: uniprot

STATE_TRANSITION_LEFT__2_acetolactate-_NADPH-RIGHT__2,3_dihydroxy_isovalerate-_NADP-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 149
left: NADPH
left: 2-acetolactate
interaction type: STATE_TRANSITION
right: 2,3-dihydroxy isovalerate
right: NADP

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__pyruvate-RIGHT__2_acetolactate-_CO2-_re5
controller: Acetolactate synthase

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P54687 33
organism: Homo sapiens

uniprot Q9Z567 104
type: UnificationXref
id: Q9Z567
db: uniprot

ncbitaxon 224324 23
type: UnificationXref
id: 224324
db: ncbitaxon

Acetolactate synthase
type: ProteinReference
xref: uniprot Q04789 85
organism: Bacillus subtilis

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q8TJJ4 117
organism: Methanosarcina acetivorans

uniprot Q9HUI8 96
type: UnificationXref
id: Q9HUI8
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q7UJ69 132
organism: Rhodopirellula baltica

uniprot Q7UKY0 113
type: UnificationXref
id: Q7UKY0
db: uniprot

uniprot O86505 26
type: UnificationXref
id: O86505
db: uniprot

uniprot P36620 80
type: UnificationXref
id: P36620
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2_ketoisovalerate-_glutamate-RIGHT__ketoglutarate-_valine-_r4
controller: Branched chain amino acid aminotransferase

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q9RU74 119
organism: Deinococcus radiodurans

uniprot F1PY28 10
type: UnificationXref
id: F1PY28
db: uniprot

Acetolactate synthase
type: ProteinReference
xref: uniprot Q9RU76 101
organism: Deinococcus radiodurans

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 53

uniprot A0A3Q1ML78 6
type: UnificationXref
id: A0A3Q1ML78
db: uniprot

uniprot Q5KPJ5 88
type: UnificationXref
id: Q5KPJ5
db: uniprot

Putative branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q58414 43
organism: Methanocaldococcus jannaschii

ncbitaxon 9615 11
type: UnificationXref
id: 9615
db: ncbitaxon

ketoglutarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 114

uniprot Q8TPV2 137
type: UnificationXref
id: Q8TPV2
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 27

uniprot Q9HVA0 97
type: UnificationXref
id: Q9HVA0
db: uniprot

Dihydroxy-acid dehydratase 2
type: ProteinReference
xref: uniprot Q8TKM8 136
organism: Methanosarcina acetivorans

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q8A612 115
organism: Bacteroides thetaiotaomicron

uniprot Q8A612 115
type: UnificationXref
id: Q8A612
db: uniprot

uniprot P37253 107
type: UnificationXref
id: P37253
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q05758 110
type: UnificationXref
id: Q05758
db: uniprot

uniprot P39522 125
type: UnificationXref
id: P39522
db: uniprot

Acetolactate synthase-like protein
type: ProteinReference
xref: uniprot O61856 74
organism: Caenorhabditis elegans

uniprot Q9RU76 101
type: UnificationXref
id: Q9RU76
db: uniprot

uniprot A6QQT9 67
type: UnificationXref
id: A6QQT9
db: uniprot

uniprot P47176 32
type: UnificationXref
id: P47176
db: uniprot

ncbitaxon 100226 27
type: UnificationXref
id: 100226
db: ncbitaxon

ncbitaxon 367110 42
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot Q6AT43 46
type: UnificationXref
id: Q6AT43
db: uniprot

2-acetolactate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P54687 33
type: UnificationXref
id: P54687
db: uniprot

Probable acetolactate synthase large subunit
type: ProteinReference
xref: uniprot Q9HWK1 98
organism: Pseudomonas aeruginosa

Probable acetolactate synthase large subunit
type: ProteinReference
xref: uniprot Q57725 86
organism: Methanocaldococcus jannaschii

Acetolactate synthase
type: ProteinReference
xref: P03216
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Valine biosynthesis.PROTEIN.GENERIC.Acetolactate_br_synthase
comment: ENTITY_REFERENCE_NOTES= Long Name: Acetolactate synthase Synonym: Synonym not specified Accession: P03216
member entity reference: Putative acetolactate synthase
member entity reference: IlvB (Bacterial acetolactate synthase)-like (Predicted), isoform CRA_c
member entity reference: Uncharacterized protein MJ0663
member entity reference: Probable 2-ketoarginine decarboxylase AruI
member entity reference: Acetolactate synthase large subunit IlvB1
member entity reference: Acetolactate synthase
member entity reference: Acetolactate synthase-like protein
member entity reference: Acetolactate synthase isozyme 1 large subunit
member entity reference: Acetolactate synthase, mitochondrial
member entity reference: Acetolactate synthase large subunit
member entity reference: Probable acetolactate synthase large subunit
member entity reference: Acetolactate synthase catalytic subunit, mitochondrial
member entity reference: Protein CBG03380
member entity reference: IlvB acetolactate synthase like
member entity reference: Acetolactate synthase, chloroplastic
member entity reference: Probable decarboxylase
member entity reference: Putative acetolactate synthase large subunit IlvB2
member entity reference: Acetolactate synthase, large subunit
member entity reference: Acetolactate synthase 1, chloroplastic
member entity reference: Acetolactate synthase large subunit IlvG
member entity reference: ILVBL isoform 1

uniprot P54688 34
type: UnificationXref
id: P54688
db: uniprot

P03218
type: UnificationXref
id: P03218
db: PANTHER Pathway Component

Dihydroxy-acid dehydratase 1
type: ProteinReference
xref: uniprot Q8TPV2 137
organism: Methanosarcina acetivorans

P03217
type: UnificationXref
id: P03217
db: PANTHER Pathway Component

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A8WM75 8
organism: Caenorhabditis briggsae

P03216
type: UnificationXref
id: P03216
db: PANTHER Pathway Component

uniprot O69198 123
type: UnificationXref
id: O69198
db: uniprot

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O67009 122
type: UnificationXref
id: O67009
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q8TI08 50
organism: Methanosarcina acetivorans

ncbitaxon 243232 44
type: UnificationXref
id: 243232
db: ncbitaxon

uniprot Q8TPF5 93
type: UnificationXref
id: Q8TPF5
db: uniprot

uniprot D4ACG2 69
type: UnificationXref
id: D4ACG2
db: uniprot

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot P38891 29
organism: Saccharomyces cerevisiae

uniprot Q9LPM9 59
type: UnificationXref
id: Q9LPM9
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 9

PARTICIPANT STOICHIOMETRY r3 148
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P24288 28
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r3 147
type: Stoichiometry
physical entity: 2 ketoisovalerate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 146
type: Stoichiometry
physical entity: 2,3-dihydroxy isovalerate
stoichiometric coefficient: 1.0

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 35

PARTICIPANT STOICHIOMETRY r2 150
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 151
type: Stoichiometry
physical entity: 2,3-dihydroxy isovalerate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 152
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

uniprot P78827 109
type: UnificationXref
id: P78827
db: uniprot

IlvB (Bacterial acetolactate synthase)-like (Predicted), isoform CRA_c
type: ProteinReference
xref: uniprot D4ACG2 69
organism: Rattus norvegicus

uniprot Q9X9Y4 142
type: UnificationXref
id: Q9X9Y4
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q8A608 133
organism: Bacteroides thetaiotaomicron

ncbitaxon 243230 62
type: UnificationXref
id: 243230
db: ncbitaxon

Acetolactate synthase, mitochondrial
type: ProteinReference
xref: uniprot P36620 80
organism: Schizosaccharomyces pombe

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

ncbitaxon 10116 19
type: UnificationXref
id: 10116
db: ncbitaxon

ncbitaxon 7165 49
type: UnificationXref
id: 7165
db: ncbitaxon

Acetolactate synthase large subunit IlvB1
type: ProteinReference
xref: uniprot P9WG41 84
organism: Mycobacterium tuberculosis

Protein CBG03380
type: ProteinReference
xref: uniprot A8WUX0 68
organism: Caenorhabditis briggsae

valine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O15382 14
type: UnificationXref
id: O15382
db: uniprot

uniprot Q8F219 134
type: UnificationXref
id: Q8F219
db: uniprot

ncbitaxon 178306 53
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot Q7SBQ5 131
type: UnificationXref
id: Q7SBQ5
db: uniprot

Ketol-acid reductoisomerase (NADP(+)) 2
type: ProteinReference
xref: uniprot Q9FBT8 118
organism: Streptomyces coelicolor

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q7UKY0 113
organism: Rhodopirellula baltica

uniprot Q9LE06 56
type: UnificationXref
id: Q9LE06
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 47

Ketol-acid reductoisomerase, chloroplastic
type: ProteinReference
xref: uniprot Q05758 110
organism: Arabidopsis thaliana

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 25

uniprot Q9RU74 119
type: UnificationXref
id: Q9RU74
db: uniprot

uniprot P9WG39 83
type: UnificationXref
id: P9WG39
db: uniprot

uniprot Q9FBT8 118
type: UnificationXref
id: Q9FBT8
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q6AT43 46
organism: Oryza sativa

uniprot Q9RTX5 61
type: UnificationXref
id: Q9RTX5
db: uniprot