Endo Peptidase
type: Protein
entity reference: Endo Peptidase
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Signal peptidase complex subunit 3
type: ProteinReference
xref: uniprot Q9VCA9 73
xref: PTHR12804:SF0
organism: Drosophila melanogaster

uniprot F8W5D0 81
type: UnificationXref
id: F8W5D0
db: uniprot

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 129

PARTICIPANT STOICHIOMETRY re3 195
type: Stoichiometry
physical entity: Pro-Vasopressin
stoichiometric coefficient: 1.0

Glycopeptide
type: Protein
entity reference: Glycopeptide
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa4 182
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re3 196
type: Stoichiometry
physical entity: Complex (Neurophysin/Glycopeptide)
stoichiometric coefficient: 1.0

Pro Neurophysin s19 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pro-Neurophysin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 194
type: Stoichiometry
physical entity: Complex (Vasopressin/Neurophysin/ Glycopeptide)
stoichiometric coefficient: 1.0

Vasotocin-neurophysin VT
type: ProteinReference
xref: uniprot P24787 89
xref: PTHR11681:SF9
organism: Gallus gallus

uniprot Q7PZC7 60
type: UnificationXref
id: Q7PZC7
db: uniprot

uniprot P67812 46
type: UnificationXref
id: P67812
db: uniprot

uniprot Q9VCA9 73
type: UnificationXref
id: Q9VCA9
db: uniprot

Pro Neurophysin s14 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pro-Neurophysin
stoichiometric coefficient: 1.0

PANTHER Pathway P04395 1
type: UnificationXref
id: P04395
db: PANTHER Pathway

uniprot P24787 89
type: UnificationXref
id: P24787
db: uniprot

ncbitaxon 9258 107
type: UnificationXref
id: 9258
db: ncbitaxon

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q9QUR6 141
organism: Mus musculus

uniprot P01178 85
type: UnificationXref
id: P01178
db: uniprot

Pro Neurophysin s9 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pro-Neurophysin
stoichiometric coefficient: 1.0

Signal peptidase complex catalytic subunit sec11
type: ProteinReference
xref: uniprot Q7RY44 61
xref: PTHR10806:SF6
organism: Neurospora crassa

Signal peptidase complex catalytic subunit SEC11C
type: ProteinReference
xref: uniprot Q9D8V7 68
xref: PTHR10806:SF12
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 17

uniprot Q9FGD4 138
type: UnificationXref
id: Q9FGD4
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 38

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 34

Neuropysin
type: Protein
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 243230 143
type: UnificationXref
id: 243230
db: ncbitaxon

Signal Peptidase
type: Protein
entity reference: Signal Peptidase
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot Q10259 47
type: UnificationXref
id: Q10259
db: uniprot

uniprot A0T4G0 11
type: UnificationXref
id: A0T4G0
db: uniprot

P04593
type: UnificationXref
id: P04593
db: PANTHER Pathway Component

P04592
type: UnificationXref
id: P04592
db: PANTHER Pathway Component

Vasopressin synthesis
type: Pathway
pathway component: TRANSPORT_LEFT__Complex__Vasopressin_Neurophysin__Glycopeptide_-RIGHT__Complex__Vasopressin_Neurophysin__Glycopeptide_-_re2
pathway component: TRUNCATION_LEFT__Pro_Neurophysin-RIGHT__Neuropysin-_Arginine-_re7
pathway component: TRUNCATION_LEFT__Pro_Vasopressin-RIGHT__Pro2_Vasopressin-_Complex__Lysine_Arginine_-_re9
pathway component: DISSOCIATION_LEFT__Complex__Neurophysin_Glycopeptide_-RIGHT__Glycopeptide-_Pro_Neurophysin-_re4
pathway component: DISSOCIATION_LEFT__Complex__Signal_Peptide_Vasopressin__Neurophysin_Glycopeptide_-RIGHT__Complex__Vasopressin_Neurophysin__Glycopeptide_-_Signal_Peptide-_re1
pathway component: DISSOCIATION_LEFT__Complex__Vasopressin_Neurophysin__Glycopeptide_-RIGHT__Pro_Vasopressin-_Complex__Neurophysin_Glycopeptide_-_re3
pathway component: TRUNCATION_LEFT__Pro2_Vasopressin-RIGHT__Vasopressin-_Glycine-_re10
xref: PANTHER Pathway P04395 1
comment: MODEL_NOTES=Panther Pathway: P04395 No pathway definition

P04591
type: UnificationXref
id: P04591
db: PANTHER Pathway Component

P04590
type: UnificationXref
id: P04590
db: PANTHER Pathway Component

P04597
type: UnificationXref
id: P04597
db: PANTHER Pathway Component

Arginine vasopressin
type: ProteinReference
xref: PTHR11681:SF9
xref: uniprot F1PZS7 78
organism: Canis lupus familiaris

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: uniprot A8WWE1 14
xref: PTHR10806:SF6
organism: Caenorhabditis briggsae

P04596
type: UnificationXref
id: P04596
db: PANTHER Pathway Component

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot O70196 113
organism: Rattus norvegicus

P04594
type: UnificationXref
id: P04594
db: PANTHER Pathway Component

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot F6TXM6 106
organism: Ornithorhynchus anatinus

P04599
type: UnificationXref
id: P04599
db: PANTHER Pathway Component

P04598
type: UnificationXref
id: P04598
db: PANTHER Pathway Component

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 62

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1
type: ProteinReference
xref: PTHR10680:SF31
xref: uniprot Q9V5E1 161
organism: Drosophila melanogaster

ncbitaxon 6238 15
type: UnificationXref
id: 6238
db: ncbitaxon

ncbitaxon 185431 120
type: UnificationXref
id: 185431
db: ncbitaxon

PREPL isoform 1
type: ProteinReference
xref: PTHR11757:SF19
xref: uniprot A0A2I3T5V5 100
organism: Pan troglodytes

uniprot Q9VKW5 145
type: UnificationXref
id: Q9VKW5
db: uniprot

Signal peptidase complex catalytic subunit SEC11A
type: ProteinReference
xref: uniprot P42667 41
xref: PTHR10806:SF28
organism: Rattus norvegicus

PTHR11681:SF13
type: RelationshipXref
id: PTHR11681:SF13
db: PANTHER Family
relationship type: By Homology

Pro-Vasopressin
type: Protein
entity reference: Pro-Vasopressin
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa8 170
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Pro-Vasopressin
type: Protein
entity reference: Pro-Vasopressin
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa5 164
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot Q2KI36 53
type: UnificationXref
id: Q2KI36
db: uniprot

PTHR11532:SF62
type: RelationshipXref
id: PTHR11532:SF62
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_Vasopressin-RIGHT__Pro2_Vasopressin-_Complex__Lysine_Arginine_-_re9
controller: Exopeptidase

uniprot F6WWE6 26
type: UnificationXref
id: F6WWE6
db: uniprot

Arginine
type: SmallMolecule
cellular location: exocytic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P04836 95
type: UnificationXref
id: P04836
db: uniprot

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot F1PHX2 103
organism: Canis lupus familiaris

uniprot Q9I440 139
type: UnificationXref
id: Q9I440
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q9RRI7 142
organism: Deinococcus radiodurans

Signal Peptide
type: ProteinReference
xref: P04597
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Signal Peptide Synonym: Synonym not specified Accession: P04597
comment: ENTITY_REFERENCE_ID_DESC=Vasopressin synthesis.PROTEIN.GENERIC.Signal Peptide
member entity reference: AVP isoform 1
member entity reference: Oxytocin-neurophysin 1
member entity reference: Oxytocin
member entity reference: Vasopressin-neurophysin 2-copeptin
member entity reference: Vasotocin-neurophysin VT
member entity reference: Arginine vasopressin (Fragment)
member entity reference: Uncharacterized protein
member entity reference: OXT isoform 1
member entity reference: Arginine vasopressin

PARTICIPANT STOICHIOMETRY re7 209
type: Stoichiometry
physical entity: Neuropysin
stoichiometric coefficient: 1.0

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 27

PARTICIPANT STOICHIOMETRY re7 208
type: Stoichiometry
physical entity: Pro-Neurophysin
stoichiometric coefficient: 1.0

ncbitaxon 7227 34
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot P71834 117
type: UnificationXref
id: P71834
db: uniprot

Lysine s1 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Lysine
stoichiometric coefficient: 1.0

Signal Peptidase
type: ProteinReference
xref: P04589
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Vasopressin synthesis.PROTEIN.GENERIC.Signal Peptidase
comment: ENTITY_REFERENCE_NOTES= Long Name: Signal Peptidase Synonym: Synonym not specified Accession: P04589
member entity reference: Signal peptidase complex catalytic subunit SEC11A
member entity reference: Signal peptidase complex catalytic subunit sec11
member entity reference: Signal peptidase subunit 3
member entity reference: Signal peptidase complex subunit 1
member entity reference: Signal peptidase complex catalytic subunit SEC11C
member entity reference: Signal peptidase complex catalytic subunit SEC11
member entity reference: Signal peptidase complex subunit 3
member entity reference: Signal peptidase I
member entity reference: Signal peptidase complex subunit 2
member entity reference: Microsomal signal peptidase 25 kDa subunit (SPC25)
member entity reference: AGAP011842-PA
member entity reference: Uncharacterized protein
member entity reference: Probable signal peptidase complex subunit 2
member entity reference: Probable signal peptidase complex subunit 3
member entity reference: Signal peptidase complex subunit SPC3
member entity reference: Probable microsomal signal peptidase subunit 3
member entity reference: Signal peptidase complex subunit 3B
member entity reference: Adipocyte-related X-chromosome expressed sequence 1

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: uniprot A0A1D5R670 4
xref: PTHR10806:SF28
organism: Macaca mulatta

uniprot Q568Z4 56
type: UnificationXref
id: Q568Z4
db: uniprot

PARTICIPANT STOICHIOMETRY re7 210
type: Stoichiometry
physical entity: Arginine
stoichiometric coefficient: 1.0

uniprot A0A3Q1LXY0 77
type: UnificationXref
id: A0A3Q1LXY0
db: uniprot

P04589
type: UnificationXref
id: P04589
db: PANTHER Pathway Component

uniprot Q00493 97
type: UnificationXref
id: Q00493
db: uniprot

Uncharacterized protein, isoform E
type: ProteinReference
xref: uniprot Q9V9P5 144
xref: PTHR42881:SF2
organism: Drosophila melanogaster

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: uniprot Q9N3D0 70
xref: PTHR10806:SF6
organism: Caenorhabditis elegans

Oligopeptidase b
type: ProteinReference
xref: uniprot Q382P7 119
organism: Trypanosoma brucei

Signal peptidase complex subunit 2
type: ProteinReference
xref: PTHR13085:SF0
xref: uniprot E1BEI2 20
organism: Bos taurus

uniprot H2QJV1 82
type: UnificationXref
id: H2QJV1
db: uniprot

Glycopeptide
type: Protein
entity reference: Glycopeptide
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa7 168
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot Q658B2 126
type: UnificationXref
id: Q658B2
db: uniprot

uniprot Q86AS5 136
type: UnificationXref
id: Q86AS5
db: uniprot

Peptidyl-glycine alpha-amidating monooxygenase
type: ProteinReference
xref: uniprot P19021 155
xref: PTHR10680:SF14
organism: Homo sapiens

Signal peptidase complex catalytic subunit SEC11A
type: ProteinReference
xref: uniprot Q9R0P6 71
xref: PTHR10806:SF28
organism: Mus musculus

uniprot P01186 88
type: UnificationXref
id: P01186
db: uniprot

Signal peptidase complex subunit 2
type: ProteinReference
xref: uniprot Q9VYY2 74
xref: PTHR13085:SF0
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re1 200
type: Stoichiometry
physical entity: Complex (Vasopressin/Neurophysin/ Glycopeptide)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 201
type: Stoichiometry
physical entity: Signal Peptide
stoichiometric coefficient: 1.0

uniprot A5A6K7 92
type: UnificationXref
id: A5A6K7
db: uniprot

uniprot Q15005 49
type: UnificationXref
id: Q15005
db: uniprot

Signal peptidase I
type: ProteinReference
xref: uniprot Q9LW08 69
xref: PTHR10806:SF27
organism: Arabidopsis thaliana

ncbitaxon 367110 62
type: UnificationXref
id: 367110
db: ncbitaxon

Peptidyl-glycine alpha-amidating monooxygenase
type: ProteinReference
xref: uniprot F1MZB4 148
xref: PTHR10680:SF14
organism: Bos taurus

uniprot H2QJV2 83
type: UnificationXref
id: H2QJV2
db: uniprot

ncbitaxon 3702 23
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot A8WWE1 14
type: UnificationXref
id: A8WWE1
db: uniprot

uniprot F7FE30 93
type: UnificationXref
id: F7FE30
db: uniprot

TRUNCATION_LEFT__Pro_Vasopressin-RIGHT__Pro2_Vasopressin-_Complex__Lysine_Arginine_-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 206
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 205
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 207
left: Pro-Vasopressin
interaction type: TRUNCATION
right: Pro2-Vasopressin
right: Complex (Lysine/Arginine)

Pro Vasopressin s11 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pro-Vasopressin
stoichiometric coefficient: 1.0

uniprot Q9LW08 69
type: UnificationXref
id: Q9LW08
db: uniprot

uniprot Q9R0P6 71
type: UnificationXref
id: Q9R0P6
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 3

Probable peptidylglycine alpha-hydroxylating monooxygenase 1
type: ProteinReference
xref: PTHR10680:SF33
xref: uniprot Q95XM2 160
organism: Caenorhabditis elegans

Complex (Vasopressin/Neurophysin/ Glycopeptide)
type: Complex
component stoichiometry: Glycopeptide s21 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pro Vasopressin s18 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pro Neurophysin s19 sa9 STOICHIOMETRY ID COMPLEX
component: Glycopeptide
component: Pro-Vasopressin
component: Pro-Neurophysin
feature: COMPLEX BINDING FEATURE s20 a23 169
feature: COMPLEX BINDING FEATURE s20 a23 171
feature: COMPLEX BINDING FEATURE s20 a23 173
cellular location: exocytic vesicle

TRUNCATION
type: RelationshipTypeVocabulary

Pro-Neurophysin
type: Protein
entity reference: Neurophysin
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot F1PHX2 103
type: UnificationXref
id: F1PHX2
db: uniprot

uniprot Q9CYN2 67
type: UnificationXref
id: Q9CYN2
db: uniprot

eco ECO:0000305 13
type: UnificationXref
id: ECO:0000305
db: eco

uniprot H2Q7G1 151
type: UnificationXref
id: H2Q7G1
db: uniprot

Oxytocin
type: ProteinReference
xref: PTHR11681:SF5
xref: uniprot F1QC27 79
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6U6 29
organism: Macaca mulatta

Carboxypeptidase E
type: ProteinReference
xref: uniprot Q6NSM5 98
xref: PTHR11532:SF62
organism: Danio rerio

NHL repeat-containing protein 3
type: ProteinReference
xref: uniprot Q5JS37 159
organism: Homo sapiens

DISSOCIATION_LEFT__Complex__Signal_Peptide_Vasopressin__Neurophysin_Glycopeptide_-RIGHT__Complex__Vasopressin_Neurophysin__Glycopeptide_-_Signal_Peptide-_re1
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 200
left: Complex (Signal Peptide/Vasopressin/ Neurophysin/Glycopeptide)
interaction type: DISSOCIATION
right: Signal Peptide
right: Complex (Vasopressin/Neurophysin/ Glycopeptide)

ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

Peptidyl-glycine alpha-amidating monooxygenase
type: ProteinReference
xref: uniprot P97467 158
xref: PTHR10680:SF14
organism: Mus musculus

uniprot P58684 42
type: UnificationXref
id: P58684
db: uniprot

Signal peptidase complex catalytic subunit sec11
type: ProteinReference
xref: uniprot Q86JD4 64
xref: PTHR10806:SF6
organism: Dictyostelium discoideum

Carboxypeptidase E
type: ProteinReference
xref: uniprot P04836 95
xref: PTHR11532:SF62
organism: Bos taurus

Signal peptidase complex subunit SPC3
type: ProteinReference
xref: PTHR12804:SF0
xref: uniprot Q12133 48
organism: Saccharomyces cerevisiae

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_Neurophysin-RIGHT__Neuropysin-_Arginine-_re7
controller: Exopeptidase

uniprot F7H6U6 29
type: UnificationXref
id: F7H6U6
db: uniprot

Signal peptidase subunit 3
type: ProteinReference
xref: PTHR12804:SF0
xref: uniprot Q7S7J6 63
organism: Neurospora crassa

PTHR13085:SF3
type: RelationshipXref
id: PTHR13085:SF3
db: PANTHER Family
relationship type: By Homology

uniprot P35454 90
type: UnificationXref
id: P35454
db: uniprot

ncbitaxon 7165 12
type: UnificationXref
id: 7165
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re10 202
type: Stoichiometry
physical entity: Pro2-Vasopressin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 203
type: Stoichiometry
physical entity: Vasopressin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 204
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

PTHR13085:SF0
type: RelationshipXref
id: PTHR13085:SF0
db: PANTHER Family
relationship type: By Homology

Complex (Neurophysin/Glycopeptide)
type: Complex
component stoichiometry: Pro Neurophysin s3 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glycopeptide s35 sa12 STOICHIOMETRY ID COMPLEX
component: Glycopeptide
component: Pro-Neurophysin
feature: COMPLEX BINDING FEATURE s23 a29 189
feature: COMPLEX BINDING FEATURE s23 a29 187
cellular location: exocytic vesicle

Probable signal peptidase complex subunit 3
type: ProteinReference
xref: PTHR12804:SF0
xref: uniprot P34525 39
organism: Caenorhabditis elegans

Glycopeptide
type: Protein
entity reference: Glycopeptide
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa12 190
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Prolyl oligopeptidase family protein
type: ProteinReference
xref: uniprot F4I2A0 105
xref: PTHR42881:SF5
organism: Arabidopsis thaliana

Prolyl endopeptidase-like
type: ProteinReference
xref: PTHR11757:SF19
xref: uniprot Q5HZA6 124
organism: Rattus norvegicus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 21

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 5

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 107

uniprot Q9V5E1 161
type: UnificationXref
id: Q9V5E1
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro2_Vasopressin-RIGHT__Vasopressin-_Glycine-_re10
controller: Amidating Enzyme

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Neurophysin_Glycopeptide_-RIGHT__Glycopeptide-_Pro_Neurophysin-_re4
controller: Endo Peptidase

uniprot A0A1D5RIY6 8
type: UnificationXref
id: A0A1D5RIY6
db: uniprot

Prolyl oligopeptidase family protein
type: ProteinReference
xref: uniprot Q9FGD4 138
organism: Arabidopsis thaliana

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: uniprot P15367 37
xref: PTHR10806:SF6
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: PTHR11681:SF2
xref: uniprot F7AXI7 80
organism: Macaca mulatta

Probable peptidyl-glycine alpha-amidating monooxygenase pamn-1
type: ProteinReference
xref: uniprot P83388 156
xref: PTHR10680:SF14
organism: Caenorhabditis elegans

Adipocyte-related X-chromosome expressed sequence 1
type: ProteinReference
xref: PTHR12804:SF6
xref: uniprot C0HK79 16
organism: Mus musculus

Prolyl endopeptidase
type: ProteinReference
xref: uniprot P48147 116
xref: PTHR42881:SF2
organism: Homo sapiens

uniprot A0A2I3T2V8 9
type: UnificationXref
id: A0A2I3T2V8
db: uniprot

uniprot Q1LVK8 50
type: UnificationXref
id: Q1LVK8
db: uniprot

Pro-Neurophysin
type: Protein
entity reference: Pro-Neurophysin
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa11 188
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot F1MZB4 148
type: UnificationXref
id: F1MZB4
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

Prolyl endopeptidase-like
type: ProteinReference
xref: PTHR11757:SF19
xref: uniprot Q8C167 137
organism: Mus musculus

Signal peptidase complex subunit 3
type: ProteinReference
xref: PTHR12804:SF0
xref: uniprot P61009 43
organism: Homo sapiens

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 36

Pro Vasopressin s18 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pro-Vasopressin
stoichiometric coefficient: 1.0

uniprot P15367 37
type: UnificationXref
id: P15367
db: uniprot

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: uniprot A0A1D5RIY6 8
xref: PTHR10806:SF12
organism: Macaca mulatta

ncbitaxon 9615 36
type: UnificationXref
id: 9615
db: ncbitaxon

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

Signal peptidase complex subunit 3
type: ProteinReference
xref: PTHR12804:SF0
xref: uniprot K7A146 30
organism: Pan troglodytes

PTHR11757:SF19
type: RelationshipXref
id: PTHR11757:SF19
db: PANTHER Family
relationship type: By Homology

Protease 2
type: ProteinReference
xref: uniprot P24555 114
organism: Escherichia coli

ncbitaxon 9606 44
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot F1MZK8 101
type: UnificationXref
id: F1MZK8
db: uniprot

uniprot Q9XWW1 76
type: UnificationXref
id: Q9XWW1
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 58

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G381 94
xref: PTHR11532:SF62
organism: Monodelphis domestica

Probable signal peptidase complex subunit 2
type: ProteinReference
xref: PTHR13085:SF0
xref: uniprot Q9XWW1 76
organism: Caenorhabditis elegans

OXT isoform 1
type: ProteinReference
xref: PTHR11681:SF2
xref: uniprot H2QJV1 82
organism: Pan troglodytes

uniprot P91268 157
type: UnificationXref
id: P91268
db: uniprot

Probable peptidase
type: ProteinReference
xref: PTHR43548:SF1
xref: uniprot O07178 111
organism: Mycobacterium tuberculosis

Exopeptidase
type: ProteinReference
xref: P04592
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Exopeptidase Synonym: CPE,CPH,carboxypeptidase E,enkephalin convertase Accession: P04592
comment: ENTITY_REFERENCE_ID_DESC=Vasopressin synthesis.PROTEIN.GENERIC.Exopeptidase
member entity reference: Carboxypeptidase E
member entity reference: Uncharacterized protein
member entity reference: Carboxypeptidase E preproprotein

Glycopeptide
type: ProteinReference
xref: P04593
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Glycopeptide Synonym: Synonym not specified Accession: P04593
comment: ENTITY_REFERENCE_ID_DESC=Vasopressin synthesis.PROTEIN.GENERIC.Glycopeptide
member entity reference: AVP isoform 1
member entity reference: Oxytocin-neurophysin 1
member entity reference: Oxytocin
member entity reference: Vasopressin-neurophysin 2-copeptin
member entity reference: Vasotocin-neurophysin VT
member entity reference: Arginine vasopressin (Fragment)
member entity reference: Uncharacterized protein
member entity reference: OXT isoform 1
member entity reference: Arginine vasopressin

AVP isoform 1
type: ProteinReference
xref: PTHR11681:SF9
xref: uniprot H2QJV2 83
organism: Pan troglodytes

ncbitaxon 9544 5
type: UnificationXref
id: 9544
db: ncbitaxon

Signal peptidase complex catalytic subunit sec11
type: ProteinReference
xref: uniprot O74323 31
xref: PTHR10806:SF6
organism: Schizosaccharomyces pombe

uniprot F6UU49 108
type: UnificationXref
id: F6UU49
db: uniprot

uniprot O07178 111
type: UnificationXref
id: O07178
db: uniprot

Arginine vasopressin (Fragment)
type: ProteinReference
xref: uniprot F8W5D0 81
xref: PTHR11681:SF13
organism: Danio rerio

Oxytocin-neurophysin 1
type: ProteinReference
xref: PTHR11681:SF2
xref: uniprot P01175 84
organism: Bos taurus

uniprot A0A1D5R670 4
type: UnificationXref
id: A0A1D5R670
db: uniprot

uniprot F1QC27 79
type: UnificationXref
id: F1QC27
db: uniprot

NHL repeat containing 3
type: ProteinReference
xref: uniprot H2Q7G1 151
organism: Pan troglodytes

Oxytocin-neurophysin 1
type: ProteinReference
xref: PTHR11681:SF2
xref: uniprot P01178 85
organism: Homo sapiens

Oxytocin-neurophysin 1
type: ProteinReference
xref: PTHR11681:SF2
xref: uniprot P01179 86
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re2 197
type: Stoichiometry
physical entity: Complex (Vasopressin/Neurophysin/ Glycopeptide)
stoichiometric coefficient: 1.0

uniprot Q9V9P5 144
type: UnificationXref
id: Q9V9P5
db: uniprot

uniprot P01179 86
type: UnificationXref
id: P01179
db: uniprot

PARTICIPANT STOICHIOMETRY re2 198
type: Stoichiometry
physical entity: Complex (Vasopressin/Neurophysin/ Glycopeptide)
stoichiometric coefficient: 1.0

Microsomal signal peptidase 25 kDa subunit (SPC25)
type: ProteinReference
xref: uniprot F4JGB4 22
xref: PTHR13085:SF0
organism: Arabidopsis thaliana

uniprot Q7PVV8 133
type: UnificationXref
id: Q7PVV8
db: uniprot

ncbitaxon 559292 38
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot O70196 113
type: UnificationXref
id: O70196
db: uniprot

uniprot A8Y1S2 147
type: UnificationXref
id: A8Y1S2
db: uniprot

Vasopressin-neurophysin 2-copeptin
type: ProteinReference
xref: uniprot P01185 87
xref: PTHR11681:SF9
organism: Homo sapiens

Signal peptidase complex subunit 2
type: ProteinReference
xref: PTHR13085:SF0
xref: uniprot D3ZD11 18
organism: Rattus norvegicus

Vasopressin-neurophysin 2-copeptin
type: ProteinReference
xref: uniprot P01186 88
xref: PTHR11681:SF9
organism: Rattus norvegicus

Pro2-Vasopressin
type: Protein
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q4J6C6 121
type: UnificationXref
id: Q4J6C6
db: uniprot

uniprot Q9SSR2 72
type: UnificationXref
id: Q9SSR2
db: uniprot

Complex (Vasopressin/Neurophysin/ Glycopeptide)
type: Complex
component stoichiometry: Pro Neurophysin s14 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pro Vasopressin s11 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glycopeptide s15 sa7 STOICHIOMETRY ID COMPLEX
component: Pro-Neurophysin
component: Glycopeptide
component: Pro-Vasopressin
feature: COMPLEX BINDING FEATURE s12 a15 165
feature: COMPLEX BINDING FEATURE s12 a15 163
feature: COMPLEX BINDING FEATURE s12 a15 167
cellular location: endoplasmic reticulum

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 15

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 40

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: uniprot A0A2I3T2V8 9
xref: PTHR10806:SF28
organism: Pan troglodytes

uniprot P14925 154
type: UnificationXref
id: P14925
db: uniprot

uniprot O97066 33
type: UnificationXref
id: O97066
db: uniprot

Signal peptidase complex catalytic subunit SEC11C
type: ProteinReference
xref: PTHR10806:SF12
xref: uniprot Q9BY50 66
organism: Homo sapiens

Pro Neurophysin s3 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pro-Neurophysin
stoichiometric coefficient: 1.0

uniprot Q28250 52
type: UnificationXref
id: Q28250
db: uniprot

ncbitaxon 5664 123
type: UnificationXref
id: 5664
db: ncbitaxon

Pro-Vasopressin
type: ProteinReference
xref: P04598
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Vasopressin synthesis.PROTEIN.GENERIC.Pro-Vasopressin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: AVP isoform 1
member entity reference: Oxytocin-neurophysin 1
member entity reference: Oxytocin
member entity reference: Vasopressin-neurophysin 2-copeptin
member entity reference: Vasotocin-neurophysin VT
member entity reference: Arginine vasopressin (Fragment)
member entity reference: Uncharacterized protein
member entity reference: OXT isoform 1
member entity reference: Arginine vasopressin

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 127

uniprot A0A2I3T5V5 100
type: UnificationXref
id: A0A2I3T5V5
db: uniprot

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 140

uniprot F6UX60 149
type: UnificationXref
id: F6UX60
db: uniprot

uniprot P48147 116
type: UnificationXref
id: P48147
db: uniprot

uniprot P97467 158
type: UnificationXref
id: P97467
db: uniprot

uniprot A0A2I3SPB4 99
type: UnificationXref
id: A0A2I3SPB4
db: uniprot

PTHR10806:SF6
type: RelationshipXref
id: PTHR10806:SF6
db: PANTHER Family
relationship type: By Homology

Pro Vasopressin s7 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pro-Vasopressin
stoichiometric coefficient: 1.0

Amidating Enzyme
type: Protein
entity reference: Amidating Enzyme
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__Complex__Vasopressin_Neurophysin__Glycopeptide_-RIGHT__Complex__Vasopressin_Neurophysin__Glycopeptide_-_re2
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 198
left: Complex (Vasopressin/Neurophysin/ Glycopeptide)
interaction type: TRANSPORT
right: Complex (Vasopressin/Neurophysin/ Glycopeptide)

uniprot F6ZSA4 110
type: UnificationXref
id: F6ZSA4
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

Vasopressin-neurophysin 2-copeptin
type: ProteinReference
xref: PTHR11681:SF9
xref: uniprot A0A3Q1LXY0 77
organism: Bos taurus

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 12

uniprot Q95XM2 160
type: UnificationXref
id: Q95XM2
db: uniprot

PTHR42881:SF5
type: RelationshipXref
id: PTHR42881:SF5
db: PANTHER Family
relationship type: By Homology

uniprot O74323 31
type: UnificationXref
id: O74323
db: uniprot

Probable microsomal signal peptidase subunit 3
type: ProteinReference
xref: PTHR12804:SF0
xref: uniprot Q10259 47
organism: Schizosaccharomyces pombe

PTHR42881:SF2
type: RelationshipXref
id: PTHR42881:SF2
db: PANTHER Family
relationship type: By Homology

ncbitaxon 13616 25
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot K7A146 30
type: UnificationXref
id: K7A146
db: uniprot

PTHR11681:SF9
type: RelationshipXref
id: PTHR11681:SF9
db: PANTHER Family
relationship type: By Homology

uniprot Q6P7Y4 59
type: UnificationXref
id: Q6P7Y4
db: uniprot

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot F6ZLE6 109
organism: Macaca mulatta

Prolyl endopeptidase like
type: ProteinReference
xref: uniprot F1MZK8 101
organism: Bos taurus

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2
type: ProteinReference
xref: uniprot Q9W1L5 162
xref: PTHR10680:SF14
organism: Drosophila melanogaster

Pro-Neurophysin
type: Protein
entity reference: Pro-Neurophysin
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa9 172
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

PTHR11681:SF2
type: RelationshipXref
id: PTHR11681:SF2
db: PANTHER Family
relationship type: By Homology

PTHR11681:SF5
type: RelationshipXref
id: PTHR11681:SF5
db: PANTHER Family
relationship type: By Homology

Glycopeptide
type: Protein
entity reference: Glycopeptide
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa10 174
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q7RY44 61
type: UnificationXref
id: Q7RY44
db: uniprot

PTHR12804:SF0
type: RelationshipXref
id: PTHR12804:SF0
db: PANTHER Family
relationship type: By Homology

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q7NMT4 130
organism: Gloeobacter violaceus

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: uniprot Q5ZMQ3 57
xref: PTHR10806:SF28
organism: Gallus gallus

Lysine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa13 184
cellular location: exocytic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 10090 17
type: UnificationXref
id: 10090
db: ncbitaxon

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

Signal peptidase complex subunit 2
type: ProteinReference
xref: uniprot Q9CYN2 67
xref: PTHR13085:SF0
organism: Mus musculus

PTHR12804:SF6
type: RelationshipXref
id: PTHR12804:SF6
db: PANTHER Family
relationship type: By Homology

uniprot F1PZS7 78
type: UnificationXref
id: F1PZS7
db: uniprot

Probable signal peptidase complex subunit 2
type: ProteinReference
xref: PTHR13085:SF0
xref: uniprot P58684 42
organism: Arabidopsis thaliana

ncbitaxon 10116 19
type: UnificationXref
id: 10116
db: ncbitaxon

Vasopressin
type: ProteinReference
xref: P04590
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Vasopressin synthesis.PROTEIN.GENERIC.Vasopressin
comment: ENTITY_REFERENCE_NOTES= Long Name: Vasopressin Synonym: Synonym not specified Accession: P04590
member entity reference: AVP isoform 1
member entity reference: Oxytocin-neurophysin 1
member entity reference: Oxytocin
member entity reference: Vasopressin-neurophysin 2-copeptin
member entity reference: Vasotocin-neurophysin VT
member entity reference: Arginine vasopressin (Fragment)
member entity reference: Uncharacterized protein
member entity reference: OXT isoform 1
member entity reference: Arginine vasopressin

Signal Peptide
type: Protein
entity reference: Signal Peptide
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa1 176
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

PTHR10680:SF14
type: RelationshipXref
id: PTHR10680:SF14
db: PANTHER Family
relationship type: By Homology

Signal peptidase complex catalytic subunit SEC11A
type: ProteinReference
xref: uniprot P67810 45
xref: PTHR10806:SF28
organism: Bos taurus

uniprot Q8C167 137
type: UnificationXref
id: Q8C167
db: uniprot

Pro-Vasopressin
type: Protein
entity reference: Pro-Vasopressin
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa2 178
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot P01185 87
type: UnificationXref
id: P01185
db: uniprot

uniprot Q9WTR7 75
type: UnificationXref
id: Q9WTR7
db: uniprot

ncbitaxon 39947 127
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q4QHU7 122
type: UnificationXref
id: Q4QHU7
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 25

Glycopeptide s15 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glycopeptide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 193
type: Stoichiometry
physical entity: Pro-Neurophysin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 192
type: Stoichiometry
physical entity: Glycopeptide
stoichiometric coefficient: 1.0

uniprot F6RRN6 24
type: UnificationXref
id: F6RRN6
db: uniprot

PAM isoform 10
type: ProteinReference
xref: PTHR10680:SF14
xref: uniprot H2R5G8 152
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re4 191
type: Stoichiometry
physical entity: Complex (Neurophysin/Glycopeptide)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 206
type: Stoichiometry
physical entity: Pro2-Vasopressin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 205
type: Stoichiometry
physical entity: Pro-Vasopressin
stoichiometric coefficient: 1.0

Peptidylglycine alpha-hydroxylating monooxygenase
type: ProteinReference
xref: uniprot O01404 153
xref: PTHR10680:SF31
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re9 207
type: Stoichiometry
physical entity: Complex (Lysine/Arginine)
stoichiometric coefficient: 1.0

uniprot P35455 91
type: UnificationXref
id: P35455
db: uniprot

PTHR43548:SF1
type: RelationshipXref
id: PTHR43548:SF1
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9913 21
type: UnificationXref
id: 9913
db: ncbitaxon

Prolyl endopeptidase like
type: ProteinReference
xref: uniprot F6UU49 108
organism: Canis lupus familiaris

By Homology
type: RelationshipTypeVocabulary

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 32

Complex (Lysine/Arginine)
type: Complex
component stoichiometry: Arginine s2 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: Lysine s1 sa13 STOICHIOMETRY ID COMPLEX
component: Lysine
component: Arginine
feature: COMPLEX BINDING FEATURE s30 a43 183
feature: COMPLEX BINDING FEATURE s30 a43 185
cellular location: exocytic vesicle

Glycopeptide s35 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glycopeptide
stoichiometric coefficient: 1.0

Signal Peptide
type: Protein
entity reference: Signal Peptide
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Carboxypeptidase E
type: ProteinReference
xref: uniprot Q00493 97
xref: PTHR11532:SF62
organism: Mus musculus

GO GO:0005783 3
type: UnificationXref
id: GO:0005783
db: GO

Glycopeptide s10 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glycopeptide
stoichiometric coefficient: 1.0

uniprot Q3T134 54
type: UnificationXref
id: Q3T134
db: uniprot

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: PTHR10806:SF6
xref: uniprot A0T4G0 11
organism: Anopheles gambiae

PTHR10680:SF33
type: RelationshipXref
id: PTHR10680:SF33
db: PANTHER Family
relationship type: By Homology

PTHR10680:SF31
type: RelationshipXref
id: PTHR10680:SF31
db: PANTHER Family
relationship type: By Homology

uniprot P42667 41
type: UnificationXref
id: P42667
db: uniprot

uniprot Q53YF3 55
type: UnificationXref
id: Q53YF3
db: uniprot

uniprot F4I2A0 105
type: UnificationXref
id: F4I2A0
db: uniprot

Peptidylglycine alpha-amidating monooxygenase
type: ProteinReference
xref: uniprot P14925 154
xref: PTHR10680:SF14
organism: Rattus norvegicus

DISSOCIATION
type: InteractionVocabulary

Signal peptidase complex subunit 3
type: ProteinReference
xref: PTHR12804:SF0
xref: uniprot F6RRN6 24
organism: Monodelphis domestica

uniprot F7G8J6 28
type: UnificationXref
id: F7G8J6
db: uniprot

uniprot Q7NMT4 130
type: UnificationXref
id: Q7NMT4
db: uniprot

AGAP011842-PA
type: ProteinReference
xref: uniprot Q7PZC7 60
xref: PTHR13085:SF0
organism: Anopheles gambiae

Probable oligopeptidase
type: ProteinReference
xref: uniprot Q9I440 139
organism: Pseudomonas aeruginosa

PTHR10806:SF12
type: RelationshipXref
id: PTHR10806:SF12
db: PANTHER Family
relationship type: By Homology

uniprot F7AXI7 80
type: UnificationXref
id: F7AXI7
db: uniprot

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q9XTA2 146
organism: Bos taurus

uniprot H2R5G8 152
type: UnificationXref
id: H2R5G8
db: uniprot

Prolyl endopeptidase-like
type: ProteinReference
xref: PTHR11757:SF19
xref: uniprot Q4J6C6 121
organism: Homo sapiens

Signal peptidase complex subunit 3
type: ProteinReference
xref: PTHR12804:SF6
xref: uniprot Q568Z4 56
organism: Rattus norvegicus

Signal peptidase I
type: ProteinReference
xref: uniprot Q9SSR2 72
xref: PTHR10806:SF6
organism: Arabidopsis thaliana

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 143

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 44

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Signal_Peptide_Vasopressin__Neurophysin_Glycopeptide_-RIGHT__Complex__Vasopressin_Neurophysin__Glycopeptide_-_Signal_Peptide-_re1
controller: Signal Peptidase

Probable protease II PtrBa [first part] (Oligopeptidase B)
type: ProteinReference
xref: uniprot P71835 118
organism: Mycobacterium tuberculosis

Probable protease II PtrBb [second part] (Oligopeptidase B)
type: ProteinReference
xref: uniprot P71834 117
organism: Mycobacterium tuberculosis

PTHR10806:SF28
type: RelationshipXref
id: PTHR10806:SF28
db: PANTHER Family
relationship type: By Homology

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: uniprot Q6P7Y4 59
xref: PTHR10806:SF28
organism: Xenopus tropicalis

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 23

PTHR10806:SF27
type: RelationshipXref
id: PTHR10806:SF27
db: PANTHER Family
relationship type: By Homology

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q86AS5 136
organism: Dictyostelium discoideum

Signal Peptide s6 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Signal Peptide
stoichiometric coefficient: 1.0

Os01g0108200 protein
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q658B2 126
organism: Oryza sativa

uniprot Q5ZKL5 125
type: UnificationXref
id: Q5ZKL5
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 112

Signal peptidase complex catalytic subunit SEC11C
type: ProteinReference
xref: PTHR10806:SF12
xref: uniprot Q9WTR7 75
organism: Rattus norvegicus

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: PTHR10806:SF12
xref: uniprot Q2KI36 53
organism: Bos taurus

Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase pgal-1
type: ProteinReference
xref: PTHR10680:SF33
xref: uniprot P91268 157
organism: Caenorhabditis elegans

Danio rerio
type: BioSource
xref: ncbitaxon 7955 51

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 115

Complex (Signal Peptide/Vasopressin/ Neurophysin/Glycopeptide)
type: Complex
component stoichiometry: Signal Peptide s6 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pro Vasopressin s7 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glycopeptide s10 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pro Neurophysin s9 sa3 STOICHIOMETRY ID COMPLEX
component: Signal Peptide
component: Glycopeptide
component: Pro-Neurophysin
component: Pro-Vasopressin
feature: COMPLEX BINDING FEATURE s8 a8 179
feature: COMPLEX BINDING FEATURE s8 a8 181
feature: COMPLEX BINDING FEATURE s8 a8 175
feature: COMPLEX BINDING FEATURE s8 a8 177
cellular location: endoplasmic reticulum

ncbitaxon 83332 112
type: UnificationXref
id: 83332
db: ncbitaxon

uniprot Q86JD4 64
type: UnificationXref
id: Q86JD4
db: uniprot

GO GO:0070382 2
type: UnificationXref
id: GO:0070382
db: GO

Signal peptidase complex subunit 3
type: ProteinReference
xref: PTHR12804:SF0
xref: uniprot F7G8J6 28
organism: Macaca mulatta

Signal peptidase complex catalytic subunit SEC11C
type: ProteinReference
xref: PTHR10806:SF12
xref: uniprot P13679 35
organism: Canis lupus familiaris

Prolyl oligopeptidase family protein
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot F4HSS5 104
organism: Arabidopsis thaliana

uniprot C0HK79 16
type: UnificationXref
id: C0HK79
db: uniprot

Glycopeptide s21 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glycopeptide
stoichiometric coefficient: 1.0

uniprot Q9XTA2 146
type: UnificationXref
id: Q9XTA2
db: uniprot

uniprot Q9N3D0 70
type: UnificationXref
id: Q9N3D0
db: uniprot

Carboxypeptidase E
type: ProteinReference
xref: PTHR11532:SF62
xref: uniprot P16870 96
organism: Homo sapiens

uniprot P71835 118
type: UnificationXref
id: P71835
db: uniprot

uniprot P83388 156
type: UnificationXref
id: P83388
db: uniprot

uniprot F1NUS2 102
type: UnificationXref
id: F1NUS2
db: uniprot

TRUNCATION_LEFT__Pro2_Vasopressin-RIGHT__Vasopressin-_Glycine-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 204
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 202
left: Pro2-Vasopressin
interaction type: TRUNCATION
right: Vasopressin
right: Glycine

uniprot Q5ZMQ3 57
type: UnificationXref
id: Q5ZMQ3
db: uniprot

uniprot P67810 45
type: UnificationXref
id: P67810
db: uniprot

Carboxypeptidase E
type: ProteinReference
xref: uniprot A5A6K7 92
xref: PTHR11532:SF62
organism: Pan troglodytes

Prolyl endopeptidase-like isoform 1
type: ProteinReference
xref: uniprot F6ZSA4 110
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BDX3 150
xref: PTHR10680:SF14
organism: Macaca mulatta

Neurophysin
type: ProteinReference
xref: P04594
comment: ENTITY_REFERENCE_ID_DESC=Vasopressin synthesis.PROTEIN.GENERIC.Neurophysin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Pro-Neurophysin Synonym: Synonym not specified Accession: P04591
member entity reference: AVP isoform 1
member entity reference: Oxytocin-neurophysin 1
member entity reference: Oxytocin
member entity reference: Vasopressin-neurophysin 2-copeptin
member entity reference: Vasotocin-neurophysin VT
member entity reference: Arginine vasopressin (Fragment)
member entity reference: Uncharacterized protein
member entity reference: OXT isoform 1
member entity reference: Arginine vasopressin

uniprot Q7UIT3 134
type: UnificationXref
id: Q7UIT3
db: uniprot

Glycine
type: SmallMolecule
cellular location: exocytic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q7NGA2 128
type: UnificationXref
id: Q7NGA2
db: uniprot

uniprot Q9QUR6 141
type: UnificationXref
id: Q9QUR6
db: uniprot

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot F1NUS2 102
organism: Gallus gallus

LP07359p
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q9VKW5 145
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Vasopressin_Neurophysin__Glycopeptide_-RIGHT__Pro_Vasopressin-_Complex__Neurophysin_Glycopeptide_-_re3
controller: Endo Peptidase

uniprot O01404 153
type: UnificationXref
id: O01404
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 65

Pro-Neurophysin
type: ProteinReference
xref: P04591
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Vasopressin synthesis.PROTEIN.GENERIC.Pro-Neurophysin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: AVP isoform 1
member entity reference: Oxytocin-neurophysin 1
member entity reference: Oxytocin
member entity reference: Vasopressin-neurophysin 2-copeptin
member entity reference: Vasotocin-neurophysin VT
member entity reference: Arginine vasopressin (Fragment)
member entity reference: Uncharacterized protein
member entity reference: OXT isoform 1
member entity reference: Arginine vasopressin

uniprot P34525 39
type: UnificationXref
id: P34525
db: uniprot

uniprot P16870 96
type: UnificationXref
id: P16870
db: uniprot

Exopeptidase
type: Protein
entity reference: Exopeptidase
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q7NGA2 128
organism: Gloeobacter violaceus

uniprot P19021 155
type: UnificationXref
id: P19021
db: uniprot

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 120

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 13

uniprot P13679 35
type: UnificationXref
id: P13679
db: uniprot

ncbitaxon 251221 129
type: UnificationXref
id: 251221
db: ncbitaxon

ncbitaxon 6239 40
type: UnificationXref
id: 6239
db: ncbitaxon

exocytic vesicle
type: CellularLocationVocabulary
xref: GO GO:0070382 2

Pro-Vasopressin
type: Protein
entity reference: Vasopressin
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7955 51
type: UnificationXref
id: 7955
db: ncbitaxon

Arginine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa14 186
cellular location: exocytic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F4HSS5 104
type: UnificationXref
id: F4HSS5
db: uniprot

Carboxypeptidase E preproprotein
type: ProteinReference
xref: uniprot F7FE30 93
xref: PTHR11532:SF62
organism: Macaca mulatta

DISSOCIATION_LEFT__Complex__Neurophysin_Glycopeptide_-RIGHT__Glycopeptide-_Pro_Neurophysin-_re4
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 192
left: Complex (Neurophysin/Glycopeptide)
interaction type: DISSOCIATION
right: Pro-Neurophysin
right: Glycopeptide

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 19

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q7UIT3 134
organism: Rhodopirellula baltica

ncbitaxon 208964 140
type: UnificationXref
id: 208964
db: ncbitaxon

Pro-Neurophysin
type: Protein
entity reference: Pro-Neurophysin
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa6 166
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot P24555 114
type: UnificationXref
id: P24555
db: uniprot

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: uniprot Q1LVK8 50
xref: PTHR10806:SF6
organism: Danio rerio

ncbitaxon 243090 135
type: UnificationXref
id: 243090
db: ncbitaxon

uniprot Q9D8V7 68
type: UnificationXref
id: Q9D8V7
db: uniprot

uniprot Q5JS37 159
type: UnificationXref
id: Q5JS37
db: uniprot

uniprot F7G381 94
type: UnificationXref
id: F7G381
db: uniprot

uniprot F6TXM6 106
type: UnificationXref
id: F6TXM6
db: uniprot

Signal peptidase complex subunit 2
type: ProteinReference
xref: uniprot Q28250 52
xref: PTHR13085:SF0
organism: Canis lupus familiaris

Amidating Enzyme
type: ProteinReference
xref: P04599
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Vasopressin synthesis.PROTEIN.GENERIC.Amidating Enzyme
comment: ENTITY_REFERENCE_NOTES= Long Name: Amidating Enzyme Synonym: Synonym not specified Accession: P04599
member entity reference: PAM isoform 10
member entity reference: Peptidylglycine alpha-hydroxylating monooxygenase
member entity reference: Peptidyl-glycine alpha-amidating monooxygenase
member entity reference: Probable peptidyl-glycine alpha-amidating monooxygenase pamn-1
member entity reference: Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase pgal-1
member entity reference: Peptidylglycine alpha-amidating monooxygenase
member entity reference: Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1
member entity reference: Probable peptidylglycine alpha-hydroxylating monooxygenase 1
member entity reference: NHL repeat-containing protein 3
member entity reference: Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2
member entity reference: Uncharacterized protein
member entity reference: NHL repeat containing 3
member entity reference: Protein CBR-PGHM-1

PARTICIPANT STOICHIOMETRY re1 199
type: Stoichiometry
physical entity: Complex (Signal Peptide/Vasopressin/ Neurophysin/Glycopeptide)
stoichiometric coefficient: 1.0

Signal peptidase complex subunit 3B
type: ProteinReference
xref: PTHR12804:SF0
xref: uniprot Q53YF3 55
organism: Arabidopsis thaliana

uniprot Q7S7J6 63
type: UnificationXref
id: Q7S7J6
db: uniprot

uniprot F6ZLE6 109
type: UnificationXref
id: F6ZLE6
db: uniprot

uniprot P61009 43
type: UnificationXref
id: P61009
db: uniprot

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 135

Signal peptidase complex subunit 3
type: ProteinReference
xref: uniprot F6WWE6 26
xref: PTHR12804:SF0
organism: Xenopus tropicalis

Oligopeptidase
type: ProteinReference
xref: uniprot Q7NPC6 132
organism: Gloeobacter violaceus

Prolyl endopeptidase-like
type: ProteinReference
xref: PTHR11757:SF19
xref: uniprot Q5ZKL5 125
organism: Gallus gallus

uniprot Q5HZA6 124
type: UnificationXref
id: Q5HZA6
db: uniprot

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q7NMZ0 131
organism: Gloeobacter violaceus

Glycopeptide
type: Protein
entity reference: Glycopeptide
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 44689 65
type: UnificationXref
id: 44689
db: ncbitaxon

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: uniprot O97066 33
xref: PTHR10806:SF6
organism: Drosophila melanogaster

TRANSPORT
type: InteractionVocabulary

Signal peptidase complex subunit 2
type: ProteinReference
xref: uniprot Q15005 49
xref: PTHR13085:SF3
organism: Homo sapiens

uniprot Q7NPC6 132
type: UnificationXref
id: Q7NPC6
db: uniprot

TRUNCATION
type: InteractionVocabulary

uniprot P01175 84
type: UnificationXref
id: P01175
db: uniprot

Vasopressin-neurophysin 2-copeptin
type: ProteinReference
xref: uniprot P35455 91
xref: PTHR11681:SF9
organism: Mus musculus

Oxytocin-neurophysin 1
type: ProteinReference
xref: PTHR11681:SF2
xref: uniprot P35454 90
organism: Mus musculus

Pro-Neurophysin
type: Protein
entity reference: Pro-Neurophysin
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa3 180
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot D3ZD11 18
type: UnificationXref
id: D3ZD11
db: uniprot

uniprot Q9BY50 66
type: UnificationXref
id: Q9BY50
db: uniprot

uniprot Q9W1L5 162
type: UnificationXref
id: Q9W1L5
db: uniprot

Protein CBR-PGHM-1
type: ProteinReference
xref: uniprot A8Y1S2 147
xref: PTHR10680:SF33
organism: Caenorhabditis briggsae

Signal peptidase complex catalytic subunit SEC11A
type: ProteinReference
xref: uniprot P67812 46
xref: PTHR10806:SF28
organism: Homo sapiens

uniprot E1BEI2 20
type: UnificationXref
id: E1BEI2
db: uniprot

ncbitaxon 284812 32
type: UnificationXref
id: 284812
db: ncbitaxon

Endo Peptidase
type: ProteinReference
xref: P04596
comment: ENTITY_REFERENCE_ID_DESC=Vasopressin synthesis.PROTEIN.GENERIC.Endo Peptidase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Endo Peptidase Synonym: PEP,PREP,Prolyl endopeptidase Accession: P04596
member entity reference: Prolyl endopeptidase
member entity reference: Prolyl endopeptidase-like
member entity reference: Probable peptidase
member entity reference: Probable protease II PtrBb [second part] (Oligopeptidase B)
member entity reference: PREPL isoform 1
member entity reference: AGAP009172-PA (Fragment)
member entity reference: Oligopeptidase b
member entity reference: Prolyl endopeptidase-like isoform 1
member entity reference: Probable oligopeptidase
member entity reference: LP07359p
member entity reference: Prolyl oligopeptidase family protein
member entity reference: Prolyl endopeptidase like
member entity reference: Protease 2
member entity reference: Oligopeptidase
member entity reference: Os01g0108200 protein
member entity reference: Probable protease II PtrBa [first part] (Oligopeptidase B)
member entity reference: Uncharacterized protein, isoform E

ncbitaxon 9031 58
type: UnificationXref
id: 9031
db: ncbitaxon

TRUNCATION_LEFT__Pro_Neurophysin-RIGHT__Neuropysin-_Arginine-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 209
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 210
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 208
left: Pro-Neurophysin
interaction type: TRUNCATION
right: Neuropysin
right: Arginine

uniprot Q6NSM5 98
type: UnificationXref
id: Q6NSM5
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 123

Oligopeptidase b
type: ProteinReference
xref: uniprot Q4QHU7 122
organism: Leishmania major

uniprot F7BDX3 150
type: UnificationXref
id: F7BDX3
db: uniprot

NHL repeat-containing protein 3
type: ProteinReference
xref: uniprot F6UX60 149
organism: Macaca mulatta

AGAP009172-PA (Fragment)
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot Q7PVV8 133
organism: Anopheles gambiae

uniprot Q7NMZ0 131
type: UnificationXref
id: Q7NMZ0
db: uniprot

Arginine s2 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Arginine
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__Complex__Vasopressin_Neurophysin__Glycopeptide_-RIGHT__Pro_Vasopressin-_Complex__Neurophysin_Glycopeptide_-_re3
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 195
left: Complex (Vasopressin/Neurophysin/ Glycopeptide)
interaction type: DISSOCIATION
right: Pro-Vasopressin
right: Complex (Neurophysin/Glycopeptide)

uniprot Q12133 48
type: UnificationXref
id: Q12133
db: uniprot

ncbitaxon 8364 27
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot Q382P7 119
type: UnificationXref
id: Q382P7
db: uniprot

ncbitaxon 83333 115
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot Q9VYY2 74
type: UnificationXref
id: Q9VYY2
db: uniprot

Vasopressin
type: Protein
entity reference: Vasopressin
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Prolyl endopeptidase
type: ProteinReference
xref: PTHR42881:SF2
xref: uniprot A0A2I3SPB4 99
organism: Pan troglodytes

uniprot F4JGB4 22
type: UnificationXref
id: F4JGB4
db: uniprot

Signal peptidase complex subunit 1
type: ProteinReference
xref: uniprot Q3T134 54
organism: Bos taurus

uniprot Q9RRI7 142
type: UnificationXref
id: Q9RRI7
db: uniprot