PARTICIPANT STOICHIOMETRY re15 115
type: Stoichiometry
physical entity: Complex (1,25-dihydroxyvitamin D/Vitamin D Receptor)
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Pre_Vitamin_D3-RIGHT__Vitamin_D3-_re21
control type: ACTIVATION
controller: UV light

PARTICIPANT STOICHIOMETRY re15 116
type: Stoichiometry
physical entity: RXR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 140
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Complex (1,25-dihydroxyvitamin D/Vitamin D Receptor)
type: Complex
component stoichiometry: VDR s6 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: 1,25 dihydroxyvitamin D s4 sa1 STOICHIOMETRY ID COMPLEX
component: 1,25-dihydroxyvitamin D
component: VDR
feature: ACTIVE 76
feature: COMPLEX BINDING FEATURE s23 a27 77
feature: COMPLEX BINDING FEATURE s23 a27 79
cellular location: cytosol

H2O
type: SmallMolecule
cellular location: liver c6
comment: SPECIES_TYPE=ION

PARTICIPANT STOICHIOMETRY re15 117
type: Stoichiometry
physical entity: Complex (RXR/VDR/ 1,25-dihydroxyvitamin D)
stoichiometric coefficient: 1.0

uniprot P11473 72
type: UnificationXref
id: P11473
db: uniprot

PARTICIPANT STOICHIOMETRY re23 141
type: Stoichiometry
physical entity: 25-hydroxy-vitamin D
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 111
type: Stoichiometry
physical entity: 25-hydroxy-vitamin D
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__1,25_dihydroxyvitamin_D-_O2-RIGHT__H2O-_1,24,25_hydroxyvitamin_D3-_re6
controller: 24-Hydroxylase

PARTICIPANT STOICHIOMETRY re3 112
type: Stoichiometry
physical entity: 25-hydroxyvitamin D
stoichiometric coefficient: 1.0

uniprot P02774 14
type: UnificationXref
id: P02774
db: uniprot

VDR
type: Protein
entity reference: VDR
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa2 80
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__25_hydroxy_vitamin_D-RIGHT__1,25_dihydroxyvitamin_D-_re24
controller: 1alpha-Hydroxylase

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

TRANSPORT
type: RelationshipTypeVocabulary

P450 reductase
type: Protein
entity reference: P450 Reductase
cellular location: liver c6
comment: SPECIES_TYPE=PROTEIN

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 60

Coagulation factor XIII B chain
type: ProteinReference
xref: uniprot P05160 33
organism: Homo sapiens

uniprot A0A2I3SRU5 5
type: UnificationXref
id: A0A2I3SRU5
db: uniprot

Vitamin D receptor
type: ProteinReference
xref: PTHR24082:SF38
xref: uniprot F1PKD9 69
organism: Canis lupus familiaris

uniprot Q05343 38
type: UnificationXref
id: Q05343
db: uniprot

PARTICIPANT STOICHIOMETRY re9 100
type: Stoichiometry
physical entity: FDX
stoichiometric coefficient: 1.0

VDR
type: ProteinReference
xref: P04606
standard name: Vitamin D Receptor
comment: ENTITY_REFERENCE_ID_DESC=Vitamin D metabolism and pathway.PROTEIN.RECEPTOR.VDR
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Vitamin D3 receptor
member entity reference: Uncharacterized protein
member entity reference: Vitamin D receptor

PTHR24082:SF38
type: RelationshipXref
id: PTHR24082:SF38
db: PANTHER Family
relationship type: By Homology

RXR
type: Protein
entity reference: RXR
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa5 90
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q4G0S4 67
type: UnificationXref
id: Q4G0S4
db: uniprot

1,25-dihydroxyvitamin D
type: SmallMolecule
cellular location: kidney c7
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7HFI3 71
type: UnificationXref
id: F7HFI3
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 19

uniprot Q7ZTI3 41
type: UnificationXref
id: Q7ZTI3
db: uniprot

NADPH--cytochrome P450 reductase
type: ProteinReference
xref: PTHR19384:SF17
xref: uniprot Q09590 54
organism: Caenorhabditis elegans

Vitamin D3 receptor
type: ProteinReference
xref: PTHR24082:SF38
xref: uniprot P11473 72
organism: Homo sapiens

ncbitaxon 7227 57
type: UnificationXref
id: 7227
db: ncbitaxon

TRANSPORT_LEFT__25_hydroxy_vitamin_D-RIGHT__25_hydroxy_vitamin_D3-_re28
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 129
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 128
left: 25-hydroxy-vitamin D
interaction type: TRANSPORT
right: 25-hydroxy-vitamin D3

VDR
type: Protein
entity reference: VDR
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa6 92
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Vitamin D3 receptor
type: ProteinReference
xref: PTHR24082:SF38
xref: uniprot P13053 73
organism: Rattus norvegicus

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 50

Vitamin D-binding protein
type: ProteinReference
xref: PTHR11385:SF11
xref: uniprot P02774 14
organism: Homo sapiens

ncbitaxon 9606 15
type: UnificationXref
id: 9606
db: ncbitaxon

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 57

1,25-dihydroxyvitamin D
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=SIMPLE_MOLECULE

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 11

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

uniprot F1PKD9 69
type: UnificationXref
id: F1PKD9
db: uniprot

Vitamin D metabolism and pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__25_hydroxy_vitamin_D-RIGHT__1,25_dihydroxyvitamin_D-_re24
pathway component: STATE_TRANSITION_LEFT__25_hydroxyvitamin_D-_O2-RIGHT__1,25_dihydroxyvitamin_D-_H2O-_re5
pathway component: TRANSPORT_LEFT__25_hydroxy_vitamin_D-RIGHT__25_hydroxy_vitamin_D3-_re28
pathway component: TRANSLATION_LEFT__24_Hydroxylase-RIGHT__24_Hydroxylase-_re35
pathway component: TRANSPORT_LEFT__1,25_dihydroxyvitamin_D-RIGHT__1,25_dihydroxyvitamin_D3-_re33
pathway component: HETERODIMER_ASSOCIATION_LEFT__1,25_dihydroxyvitamin_D-_DBP-RIGHT__Complex__DBP_1,25_dihydroxyvitamin_D_-_re29
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__1,25_dihydroxyvitamin_D_Vitamin_D_Receptor_-_RXR-RIGHT__Complex__RXR_VDR__1,25_dihydroxyvitamin_D_-_re15
pathway component: HETERODIMER_ASSOCIATION_LEFT__VDR-_1,25_dihydroxyvitamin_D3-RIGHT__Complex__1,25_dihydroxyvitamin_D_Vitamin_D_Receptor_-_re12
pathway component: STATE_TRANSITION_LEFT__1alpha_Hydroxylase-RIGHT__1alpha_Hydroxylase-_re7
pathway component: TRANSPORT_LEFT__25_hydroxy_vitamin_D3-RIGHT__25_hydroxy_vitamin_D-_re2
pathway component: STATE_TRANSITION_LEFT__1,25_dihydroxyvitamin_D-_O2-RIGHT__H2O-_1,24,25_hydroxyvitamin_D3-_re6
pathway component: TRANSPORT_LEFT__1,25_dihydroxyvitamin_D-RIGHT__1,25_dihydroxyvitamin_D-_re25
pathway component: TRANSPORT_LEFT__1,25_dihydroxyvitamin_D-RIGHT__1,25_dihydroxyvitamin_D3-_re1
pathway component: STATE_TRANSITION_LEFT__O2-_Vitamin_D3-_NADPH-RIGHT__NADP_PLUS_-_H2O-_25_hydroxy_vitamin_D-_re23
pathway component: TRANSPORT_LEFT__25_hydroxy_vitamin_D-RIGHT__25_hydroxyvitamin_D-_re3
pathway component: TRANSPORT_LEFT__Vitamin_D3-RIGHT__Vitamin_D3-_re22
pathway component: STATE_TRANSITION_LEFT__FDX-_NADPH-RIGHT__NADP_PLUS_-_FDX-_re9
pathway component: MODULATION
pathway component: TRANSPORT_LEFT__25_hydroxy_vitamin_D-RIGHT__25_hydroxy_vitamin_D-_re26
pathway component: TRANSCRIPTION_LEFT__VDRE-RIGHT__VDRE-_re36
pathway component: TRANSCRIPTION_LEFT__24_Hydroxylase-RIGHT__24_Hydroxylase-_re34
pathway component: STATE_TRANSITION_LEFT__Pre_Vitamin_D3-RIGHT__Vitamin_D3-_re21
pathway component: TRANSPORT_LEFT__Complex__1,25_dihydroxyvitamin_D_Vitamin_D_Receptor_-RIGHT__Complex__1,25_dihydroxyvitamin_D_Vitamin_D_Receptor_-_re13
xref: PANTHER Pathway P04396 1
comment: MODEL_NOTES= Diagram of metabolism and activity of Vitamin D free text=Chapters 2,3,4,5,6,8,13,14

STATE_TRANSITION_LEFT__1,25_dihydroxyvitamin_D-_O2-RIGHT__H2O-_1,24,25_hydroxyvitamin_D3-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 106
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 104
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 105
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 103
left: O2
left: 1,25-dihydroxyvitamin D
interaction type: STATE_TRANSITION
right: H2O
right: 1,24,25-hydroxyvitamin D3

24-Hydroxylase
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Retinoic acid receptor alpha
type: ProteinReference
xref: uniprot F7BMR6 30
organism: Monodelphis domestica

liver c6
type: CellularLocationVocabulary
comment: liver

uniprot P37040 53
type: UnificationXref
id: P37040
db: uniprot

ncbitaxon 8364 29
type: UnificationXref
id: 8364
db: ncbitaxon

kidney c7
type: CellularLocationVocabulary
comment: kidney

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
type: ProteinReference
xref: PTHR24291:SF3
xref: uniprot O15528 24
organism: Homo sapiens

uniprot E1BN35 20
type: UnificationXref
id: E1BN35
db: uniprot

1alpha-Hydroxylase
type: ProteinReference
xref: P04603
standard name: Vitamin D 1-alpha-hydroxylase
comment: ENTITY_REFERENCE_NOTES= Long Name: Vitamin D 1-alpha-hydroxylase Synonym: CYP1,CYP27B1,P450c1,VDDR Accession: P04603
comment: ENTITY_REFERENCE_ID_DESC=Vitamin D metabolism and pathway.PROTEIN.GENERIC.1_alpha_-Hydroxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
member entity reference: Sterol 26-hydroxylase, mitochondrial
member entity reference: Cytochrome P450 27C1
member entity reference: CYP27A1 isoform 1
member entity reference: CYP27B1 isoform 2
member entity reference: Uncharacterized protein
member entity reference: CYP27C1 isoform 1

TRANSPORT_LEFT__25_hydroxy_vitamin_D-RIGHT__25_hydroxy_vitamin_D-_re26
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 131
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 130
left: 25-hydroxy-vitamin D
interaction type: TRANSPORT
right: 25-hydroxy-vitamin D

uniprot H2R9N8 32
type: UnificationXref
id: H2R9N8
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 31

PARTICIPANT STOICHIOMETRY re23 137
type: Stoichiometry
physical entity: Vitamin D3
stoichiometric coefficient: 1.0

uniprot P48281 74
type: UnificationXref
id: P48281
db: uniprot

VDRE
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY re23 136
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

uniprot F1NVF3 9
type: UnificationXref
id: F1NVF3
db: uniprot

PARTICIPANT STOICHIOMETRY re23 138
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 139
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

uniprot Q27597 56
type: UnificationXref
id: Q27597
db: uniprot

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
type: ProteinReference
xref: PTHR24291:SF3
xref: uniprot O35084 25
organism: Mus musculus

uniprot Q5FBR4 39
type: UnificationXref
id: Q5FBR4
db: uniprot

uniprot P21614 18
type: UnificationXref
id: P21614
db: uniprot

eco ECO:0000353 11
type: UnificationXref
id: ECO:0000353
db: eco

PANTHER Pathway P04396 1
type: UnificationXref
id: P04396
db: PANTHER Pathway

uniprot Q90271 43
type: UnificationXref
id: Q90271
db: uniprot

TRANSLATION
type: RelationshipTypeVocabulary

1,24,25-hydroxyvitamin D3
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 52

Retinoic acid receptor alpha
type: ProteinReference
xref: uniprot P11416 35
organism: Mus musculus

GC, vitamin D binding protein
type: ProteinReference
xref: PTHR11385:SF11
xref: uniprot A0A2I3SRU5 5
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re7 102
type: Stoichiometry
physical entity: 1alpha-Hydroxylase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 101
type: Stoichiometry
physical entity: 1alpha-Hydroxylase
stoichiometric coefficient: 1.0

TRANSCRIPTION
type: InteractionVocabulary

24-Hydroxylase
type: Protein
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9031 10
type: UnificationXref
id: 9031
db: ncbitaxon

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 6

PTHR19384:SF17
type: RelationshipXref
id: PTHR19384:SF17
db: PANTHER Family
relationship type: By Homology

NADPH--cytochrome P450 reductase
type: ProteinReference
xref: PTHR19384:SF17
xref: uniprot P37040 53
organism: Mus musculus

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 29

HETERODIMER_ASSOCIATION_LEFT__Complex__1,25_dihydroxyvitamin_D_Vitamin_D_Receptor_-_RXR-RIGHT__Complex__RXR_VDR__1,25_dihydroxyvitamin_D_-_re15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 116
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 115
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 117
left: RXR
left: Complex (1,25-dihydroxyvitamin D/Vitamin D Receptor)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (RXR/VDR/ 1,25-dihydroxyvitamin D)

Vitamin D3
type: SmallMolecule
cellular location: liver c6
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Retinoic acid receptor alpha
type: ProteinReference
xref: uniprot P10276 34
organism: Homo sapiens

uniprot A0A2J8M1N6 61
type: UnificationXref
id: A0A2J8M1N6
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Growth Inhibition
controller: VDRE

G04688
type: UnificationXref
id: G04688
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re24 134
type: Stoichiometry
physical entity: 25-hydroxy-vitamin D
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 135
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 103
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

NADPH--cytochrome P450 reductase
type: ProteinReference
xref: PTHR19384:SF17
xref: uniprot P00388 47
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re6 105
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

ncbitaxon 9615 40
type: UnificationXref
id: 9615
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re6 104
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 106
type: Stoichiometry
physical entity: 1,24,25-hydroxyvitamin D3
stoichiometric coefficient: 1.0

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
type: DnaReference
xref: PTHR24291:SF5
organism: Mus musculus

STATE_TRANSITION_LEFT__25_hydroxy_vitamin_D-RIGHT__1,25_dihydroxyvitamin_D-_re24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 135
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 134
left: 25-hydroxy-vitamin D
interaction type: STATE_TRANSITION
right: 1,25-dihydroxyvitamin D

uniprot P05160 33
type: UnificationXref
id: P05160
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FDX-_NADPH-RIGHT__NADP_PLUS_-_FDX-_re9
controller: FdxR

ncbitaxon 7955 42
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot H2QUS7 46
type: UnificationXref
id: H2QUS7
db: uniprot

uniprot A0A0G2JW78 26
type: UnificationXref
id: A0A0G2JW78
db: uniprot

Vitamin D-binding protein
type: ProteinReference
xref: PTHR11385:SF11
xref: uniprot P04276 16
organism: Rattus norvegicus

DBP s30 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DBP
stoichiometric coefficient: 1.0

Retinoic acid receptor, alpha
type: ProteinReference
xref: uniprot A0A0G2JW78 26
organism: Rattus norvegicus

uniprot P17178 65
type: UnificationXref
id: P17178
db: uniprot

NADPH--cytochrome P450 reductase
type: ProteinReference
xref: uniprot P36587 51
xref: PTHR19384:SF17
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY re2 114
type: Stoichiometry
physical entity: 25-hydroxy-vitamin D
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 113
type: Stoichiometry
physical entity: 25-hydroxy-vitamin D3
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 15

1,25-dihydroxyvitamin D
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa1 78
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

MODULATION
type: Control
xref: MODULATION
controlled: Differentiation
controller: VDRE

ncbitaxon 6239 55
type: UnificationXref
id: 6239
db: ncbitaxon

Retinoic acid receptor RXR-alpha
type: ProteinReference
xref: uniprot P28700 37
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re5 109
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

VDR s14 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VDR
stoichiometric coefficient: 1.0

DBP
type: Protein
entity reference: DBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa8 86
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re12 122
type: Stoichiometry
physical entity: VDR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 107
type: Stoichiometry
physical entity: 25-hydroxyvitamin D
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 108
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 127
type: Stoichiometry
physical entity: Complex (DBP/1,25-dihydroxyvitamin D)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MWQ3 27
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re29 126
type: Stoichiometry
physical entity: DBP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 123
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 125
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 124
type: Stoichiometry
physical entity: Complex (1,25-dihydroxyvitamin D/Vitamin D Receptor)
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__24_Hydroxylase-RIGHT__24_Hydroxylase-_re35
type: TemplateReaction
product: 24-Hydroxylase
xref: TRANSLATION
participant: 24-Hydroxylase
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

eco ECO:0000304 48
type: UnificationXref
id: ECO:0000304
db: eco

uniprot F6XQK9 28
type: UnificationXref
id: F6XQK9
db: uniprot

By Homology
type: RelationshipTypeVocabulary

GO GO:0005829 4
type: UnificationXref
id: GO:0005829
db: GO

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__O2-_Vitamin_D3-_NADPH-RIGHT__NADP_PLUS_-_H2O-_25_hydroxy_vitamin_D-_re23
controller: P450 reductase

O2
type: SmallMolecule
cellular location: liver c6
comment: SPECIES_TYPE=ION

25-hydroxy-vitamin D
type: SmallMolecule
cellular location: kidney c7
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1,25 dihydroxyvitamin D s31 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

uniprot H2Q6C4 23
type: UnificationXref
id: H2Q6C4
db: uniprot

DBP
type: Protein
entity reference: DBP
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re22 143
type: Stoichiometry
physical entity: Vitamin D3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 142
type: Stoichiometry
physical entity: Vitamin D3
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__O2-_Vitamin_D3-_NADPH-RIGHT__NADP_PLUS_-_H2O-_25_hydroxy_vitamin_D-_re23
controller: 25-Hydroxylase

PARTICIPANT STOICHIOMETRY re21 145
type: Stoichiometry
physical entity: Vitamin D3
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__1,25_dihydroxyvitamin_D-RIGHT__1,25_dihydroxyvitamin_D3-_re1
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 118
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 119
left: 1,25-dihydroxyvitamin D
interaction type: TRANSPORT
right: 1,25-dihydroxyvitamin D3

1,25-dihydroxyvitamin D
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa9 88
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Danio rerio
type: BioSource
xref: ncbitaxon 7955 42

Vitamin D receptor
type: ProteinReference
xref: PTHR24082:SF38
xref: uniprot F7B2T2 70
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY re21 144
type: Stoichiometry
physical entity: Pre-Vitamin D3
stoichiometric coefficient: 1.0

uniprot A0A1D5Q4C0 44
type: UnificationXref
id: A0A1D5Q4C0
db: uniprot

NADPH
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=ION

TRANSPORT_LEFT__25_hydroxy_vitamin_D-RIGHT__25_hydroxyvitamin_D-_re3
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 112
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 111
left: 25-hydroxy-vitamin D
interaction type: TRANSPORT
right: 25-hydroxyvitamin D

PARTICIPANT STOICHIOMETRY re5 110
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Sterol 26-hydroxylase, mitochondrial
type: ProteinReference
xref: PTHR24291:SF6
xref: uniprot Q9DBG1 68
organism: Mus musculus

uniprot K7CD19 63
type: UnificationXref
id: K7CD19
db: uniprot

PARTICIPANT STOICHIOMETRY re9 99
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 97
type: Stoichiometry
physical entity: FDX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 98
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

VDR
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24082:SF38
xref: uniprot F7HFI3 71
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re28 128
type: Stoichiometry
physical entity: 25-hydroxy-vitamin D
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 129
type: Stoichiometry
physical entity: 25-hydroxy-vitamin D3
stoichiometric coefficient: 1.0

uniprot P28700 37
type: UnificationXref
id: P28700
db: uniprot

uniprot F7BMR6 30
type: UnificationXref
id: F7BMR6
db: uniprot

uniprot F1P7R1 45
type: UnificationXref
id: F1P7R1
db: uniprot

uniprot F7H3A6 22
type: UnificationXref
id: F7H3A6
db: uniprot

uniprot F1MWQ3 27
type: UnificationXref
id: F1MWQ3
db: uniprot

RXR
type: ProteinReference
xref: P04602
standard name: Retinoid X Receptor, Alpha
comment: ENTITY_REFERENCE_ID_DESC=Vitamin D metabolism and pathway.PROTEIN.RECEPTOR.RXR
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Retinoic acid receptor alpha
member entity reference: Retinoic acid receptor RXR-alpha
member entity reference: Retinoic acid receptor alpha-A
member entity reference: Coagulation factor XIII B chain
member entity reference: Retinoic acid receptor, alpha
member entity reference: Uncharacterized protein
member entity reference: Retinoic acid receptor alpha-B

PTHR24291:SF9
type: RelationshipXref
id: PTHR24291:SF9
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__1,25_dihydroxyvitamin_D-_DBP-RIGHT__Complex__DBP_1,25_dihydroxyvitamin_D_-_re29
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 125
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 126
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 127
left: 1,25-dihydroxyvitamin D
left: DBP
interaction type: HETERODIMER_ASSOCIATION
right: Complex (DBP/1,25-dihydroxyvitamin D)

PARTICIPANT STOICHIOMETRY re25 132
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

PTHR24291:SF6
type: RelationshipXref
id: PTHR24291:SF6
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re25 133
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

PTHR24291:SF5
type: RelationshipXref
id: PTHR24291:SF5
db: PANTHER Family
relationship type: By Homology

NADPH--cytochrome P450 reductase
type: ProteinReference
xref: PTHR19384:SF17
xref: uniprot H2QUS7 46
organism: Pan troglodytes

ncbitaxon 9913 21
type: UnificationXref
id: 9913
db: ncbitaxon

PTHR24291:SF3
type: RelationshipXref
id: PTHR24291:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q09590 54
type: UnificationXref
id: Q09590
db: uniprot

uniprot F7HD06 62
type: UnificationXref
id: F7HD06
db: uniprot

TRANSCRIPTION
type: RelationshipTypeVocabulary

uniprot P00388 47
type: UnificationXref
id: P00388
db: uniprot

ncbitaxon 10116 17
type: UnificationXref
id: 10116
db: ncbitaxon

FDX
type: Protein
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

Retinoic acid receptor RXR-alpha
type: ProteinReference
xref: uniprot Q05343 38
organism: Rattus norvegicus

MODULATION
type: RelationshipTypeVocabulary

uniprot O35084 25
type: UnificationXref
id: O35084
db: uniprot

CYP27B1 isoform 2
type: ProteinReference
xref: uniprot H2Q6C4 23
xref: PTHR24291:SF3
organism: Pan troglodytes

uniprot P10276 34
type: UnificationXref
id: P10276
db: uniprot

ncbitaxon 559292 50
type: UnificationXref
id: 559292
db: ncbitaxon

Bos taurus
type: BioSource
xref: ncbitaxon 9913 21

1,25-dihydroxyvitamin D
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa3 82
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re26 131
type: Stoichiometry
physical entity: 25-hydroxy-vitamin D
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

H2O
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=ION

RXR
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Vitamin D3 receptor
type: ProteinReference
xref: PTHR24082:SF38
xref: uniprot Q28037 75
organism: Bos taurus

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 13

PARTICIPANT STOICHIOMETRY re26 130
type: Stoichiometry
physical entity: 25-hydroxy-vitamin D
stoichiometric coefficient: 1.0

Vitamin D-binding protein
type: ProteinReference
xref: PTHR11385:SF11
xref: uniprot P21614 18
organism: Mus musculus

TRANSLATION
type: InteractionVocabulary

VDR s6 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VDR
stoichiometric coefficient: 1.0

ncbitaxon 284812 52
type: UnificationXref
id: 284812
db: ncbitaxon

NADPH--cytochrome P450 reductase
type: ProteinReference
xref: PTHR19384:SF17
xref: uniprot Q27597 56
organism: Drosophila melanogaster

uniprot Q7QFI3 59
type: UnificationXref
id: Q7QFI3
db: uniprot

PARTICIPANT STOICHIOMETRY re33 96
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D3
stoichiometric coefficient: 1.0

Retinoic acid receptor alpha
type: ProteinReference
xref: uniprot H2R9N8 32
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re33 95
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

P450 Reductase
type: ProteinReference
xref: P04605
standard name: cytochrome P450 reductase
comment: ENTITY_REFERENCE_NOTES= Long Name: cytochrome P450 reductase Synonym: CYPOR,P450 (cytochrome) oxidoreductase,POR Accession: P04605
comment: ENTITY_REFERENCE_ID_DESC=Vitamin D metabolism and pathway.PROTEIN.GENERIC.P450_br_Reductase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: NADPH--cytochrome P450 reductase
member entity reference: AGAP000500-PA

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__VDRE-RIGHT__VDRE-_re36
control type: ACTIVATION
controller: Complex (RXR/VDR/ 1,25-dihydroxyvitamin D)

Pre-Vitamin D3
type: SmallMolecule
cellular location: Skin c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 48

NADPH--cytochrome P450 reductase
type: ProteinReference
xref: PTHR19384:SF17
xref: uniprot P16603 49
organism: Saccharomyces cerevisiae

Retinoic acid receptor alpha
type: ProteinReference
xref: uniprot F6XQK9 28
organism: Xenopus tropicalis

1,25 dihydroxyvitamin D s13 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__25_hydroxy_vitamin_D3-RIGHT__25_hydroxy_vitamin_D-_re2
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 114
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 113
left: 25-hydroxy-vitamin D3
interaction type: TRANSPORT
right: 25-hydroxy-vitamin D

uniprot P04276 16
type: UnificationXref
id: P04276
db: uniprot

Sterol 26-hydroxylase, mitochondrial
type: ProteinReference
xref: PTHR24291:SF6
xref: uniprot P17178 65
organism: Rattus norvegicus

1alpha-Hydroxylase
type: Protein
feature: ACTIVE 76
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

CYP27C1 isoform 1
type: ProteinReference
xref: uniprot A0A2J8M1N6 61
xref: PTHR24291:SF9
organism: Pan troglodytes

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
type: ProteinReference
xref: uniprot F7H3A6 22
xref: PTHR24291:SF3
organism: Macaca mulatta

NADPH
type: SmallMolecule
cellular location: liver c6
comment: SPECIES_TYPE=ION

DBP
type: ProteinReference
xref: P04600
standard name: Vitamin D binding protein
comment: ENTITY_REFERENCE_ID_DESC=Vitamin D metabolism and pathway.PROTEIN.GENERIC.DBP
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Vitamin D binding protein Synonym: GC,VDBG,VDBP Accession: P04600
member entity reference: Vitamin D-binding protein
member entity reference: Uncharacterized protein
member entity reference: GC, vitamin D binding protein

uniprot Q28037 75
type: UnificationXref
id: Q28037
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__24_Hydroxylase-RIGHT__24_Hydroxylase-_re34
control type: ACTIVATION
controller: Complex (RXR/VDR/ 1,25-dihydroxyvitamin D)

25-hydroxy-vitamin D3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ACTIVE 76
type: EntityFeature
comment: Active state

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

NADPH--cytochrome P450 reductase
type: ProteinReference
xref: uniprot A0A1D5Q4C0 44
xref: PTHR19384:SF17
organism: Macaca mulatta

Differentiation
type: Pathway

uniprot P16603 49
type: UnificationXref
id: P16603
db: uniprot

STATE_TRANSITION_LEFT__O2-_Vitamin_D3-_NADPH-RIGHT__NADP_PLUS_-_H2O-_25_hydroxy_vitamin_D-_re23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 141
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 136
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 137
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 140
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 139
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 138
left: Vitamin D3
left: O2
left: NADPH
interaction type: STATE_TRANSITION
right: NADP+
right: 25-hydroxy-vitamin D
right: H2O

CATALYSIS
type: Catalysis
controller: FDX

uniprot Q02318 66
type: UnificationXref
id: Q02318
db: uniprot

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

1,25-dihydroxyvitamin D
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cytochrome P450 27C1
type: ProteinReference
xref: uniprot Q4G0S4 67
xref: PTHR24291:SF9
organism: Homo sapiens

Growth Inhibition
type: Pathway

Vitamin D3 receptor
type: ProteinReference
xref: PTHR24082:SF38
xref: uniprot P48281 74
organism: Mus musculus

TRANSPORT_LEFT__Vitamin_D3-RIGHT__Vitamin_D3-_re22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 142
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 143
left: Vitamin D3
interaction type: TRANSPORT
right: Vitamin D3

uniprot P11416 35
type: UnificationXref
id: P11416
db: uniprot

VDRE
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

uniprot P19793 36
type: UnificationXref
id: P19793
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 17

1,25-dihydroxyvitamin D3
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Sterol 26-hydroxylase, mitochondrial
type: ProteinReference
xref: PTHR24291:SF6
xref: uniprot Q02318 66
organism: Homo sapiens

STATE_TRANSITION_LEFT__25_hydroxyvitamin_D-_O2-RIGHT__1,25_dihydroxyvitamin_D-_H2O-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 108
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 109
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 107
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 110
left: O2
left: 25-hydroxyvitamin D
interaction type: STATE_TRANSITION
right: H2O
right: 1,25-dihydroxyvitamin D

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 40

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

1,25 dihydroxyvitamin D s26 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

24-Hydroxylase
type: DnaRegion
entity reference: Vitamin D 24-Hydroxylase
cellular location: nucleus
comment: SPECIES_TYPE=GENE

uniprot F7B2T2 70
type: UnificationXref
id: F7B2T2
db: uniprot

ncbitaxon 10090 19
type: UnificationXref
id: 10090
db: ncbitaxon

AGAP000500-PA
type: ProteinReference
xref: PTHR19384:SF17
xref: uniprot Q7QFI3 59
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY re1 118
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 119
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D3
stoichiometric coefficient: 1.0

ncbitaxon 13616 31
type: UnificationXref
id: 13616
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BN35 20
xref: PTHR24291:SF3
organism: Bos taurus

TRANSPORT_LEFT__1,25_dihydroxyvitamin_D-RIGHT__1,25_dihydroxyvitamin_D-_re25
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 132
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 133
left: 1,25-dihydroxyvitamin D
interaction type: TRANSPORT
right: 1,25-dihydroxyvitamin D

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 10

GC, vitamin D binding protein
type: ProteinReference
xref: PTHR11385:SF11
xref: uniprot F1NVF3 9
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__1alpha_Hydroxylase-RIGHT__1alpha_Hydroxylase-_re7
controller: FDX

Complex (DBP/1,25-dihydroxyvitamin D)
type: Complex
component stoichiometry: 1,25 dihydroxyvitamin D s31 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: DBP s30 sa8 STOICHIOMETRY ID COMPLEX
component: 1,25-dihydroxyvitamin D
component: DBP
feature: COMPLEX BINDING FEATURE s55 a63 85
feature: COMPLEX BINDING FEATURE s55 a63 87

STATE_TRANSITION_LEFT__Pre_Vitamin_D3-RIGHT__Vitamin_D3-_re21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 145
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 144
left: Pre-Vitamin D3
interaction type: STATE_TRANSITION
right: Vitamin D3

uniprot P13053 73
type: UnificationXref
id: P13053
db: uniprot

NADPH--cytochrome P450 reductase
type: ProteinReference
xref: PTHR19384:SF17
xref: uniprot F1P7R1 45
organism: Canis lupus familiaris

TRANSCRIPTION_LEFT__24_Hydroxylase-RIGHT__24_Hydroxylase-_re34
type: TemplateReaction
product: 24-Hydroxylase
xref: TRANSCRIPTION
participant: 24-Hydroxylase
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

ncbitaxon 9598 6
type: UnificationXref
id: 9598
db: ncbitaxon

GO GO:0005739 3
type: UnificationXref
id: GO:0005739
db: GO

uniprot Q9DBG1 68
type: UnificationXref
id: Q9DBG1
db: uniprot

1,25-dihydroxyvitamin D
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa7 94
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TRANSPORT_LEFT__Complex__1,25_dihydroxyvitamin_D_Vitamin_D_Receptor_-RIGHT__Complex__1,25_dihydroxyvitamin_D_Vitamin_D_Receptor_-_re13
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 120
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 121
left: Complex (1,25-dihydroxyvitamin D/Vitamin D Receptor)
interaction type: TRANSPORT
right: Complex (1,25-dihydroxyvitamin D/Vitamin D Receptor)

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__25_hydroxyvitamin_D-_O2-RIGHT__1,25_dihydroxyvitamin_D-_H2O-_re5
controller: 1alpha-Hydroxylase

NADPH--cytochrome P450 reductase
type: ProteinReference
xref: uniprot Q3SYT8 58
xref: PTHR19384:SF17
organism: Bos taurus

STATE_TRANSITION_LEFT__1alpha_Hydroxylase-RIGHT__1alpha_Hydroxylase-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 102
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 101
left: 1alpha-Hydroxylase
interaction type: STATE_TRANSITION
right: 1alpha-Hydroxylase

25-hydroxy-vitamin D
type: SmallMolecule
cellular location: liver c6
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1alpha-Hydroxylase
type: Protein
entity reference: 1alpha-Hydroxylase
cellular location: kidney c7
comment: SPECIES_TYPE=PROTEIN

25-hydroxy-vitamin D
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

IDA
type: EvidenceCodeVocabulary

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
type: DnaReference
xref: PTHR24291:SF5
organism: Homo sapiens

Retinoic acid receptor alpha-A
type: ProteinReference
xref: uniprot Q90271 43
organism: Danio rerio

Sterol 26-hydroxylase, mitochondrial
type: ProteinReference
xref: PTHR24291:SF6
xref: uniprot F7HD06 62
organism: Macaca mulatta

Vitamin D 24-Hydroxylase
type: DnaRegionReference
member entity reference: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
member entity reference: Uncharacterized protein
xref: G04688
comment: ENTITY_REFERENCE_ID_DESC=Vitamin D metabolism and pathway.GENE.GENE.24-Hydroxylase
comment: ENTITY_REFERENCE_NOTES= Long Name: 24-Hydroxylase Synonym: CP24,CYP24,CYP42A1,cytochrome P450 24A1 Accession: G04688
display name: 24-Hydroxylase

NADP+
type: SmallMolecule
cellular location: liver c6
comment: SPECIES_TYPE=ION

RXR s17 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RXR
stoichiometric coefficient: 1.0

Complex (RXR/VDR/ 1,25-dihydroxyvitamin D)
type: Complex
component stoichiometry: RXR s17 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: 1,25 dihydroxyvitamin D s26 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: VDR s22 sa6 STOICHIOMETRY ID COMPLEX
component: VDR
component: RXR
component: 1,25-dihydroxyvitamin D
feature: ACTIVE 76
feature: COMPLEX BINDING FEATURE s33 a39 91
feature: COMPLEX BINDING FEATURE s33 a39 93
feature: COMPLEX BINDING FEATURE s33 a39 89
cellular location: nucleus

O2
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=ION

uniprot F6WR34 12
type: UnificationXref
id: F6WR34
db: uniprot

Retinoic acid receptor alpha
type: ProteinReference
xref: uniprot Q5FBR4 39
organism: Canis lupus familiaris

uniprot O15528 24
type: UnificationXref
id: O15528
db: uniprot

25-Hydroxylase
type: ProteinReference
xref: P04601
standard name: Vitamin D 25-Hydroxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Vitamin D metabolism and pathway.PROTEIN.GENERIC.25-Hydroxylase
comment: ENTITY_REFERENCE_NOTES= Long Name: Vitamin D 25-Hydroxylase Synonym: CYP27A1,cytochrome P450 27A1 Accession: P04601
member entity reference: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
member entity reference: CYP27B1 isoform 2
member entity reference: Uncharacterized protein

PTHR11385:SF11
type: RelationshipXref
id: PTHR11385:SF11
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re13 121
type: Stoichiometry
physical entity: Complex (1,25-dihydroxyvitamin D/Vitamin D Receptor)
stoichiometric coefficient: 1.0

Vitamin D3
type: SmallMolecule
cellular location: Skin c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P04603
type: UnificationXref
id: P04603
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re13 120
type: Stoichiometry
physical entity: Complex (1,25-dihydroxyvitamin D/Vitamin D Receptor)
stoichiometric coefficient: 1.0

P04602
type: UnificationXref
id: P04602
db: PANTHER Pathway Component

P04605
type: UnificationXref
id: P04605
db: PANTHER Pathway Component

NADP+
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=ION

TRANSPORT_LEFT__1,25_dihydroxyvitamin_D-RIGHT__1,25_dihydroxyvitamin_D3-_re33
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 95
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 96
left: 1,25-dihydroxyvitamin D
interaction type: TRANSPORT
right: 1,25-dihydroxyvitamin D3

P04606
type: UnificationXref
id: P04606
db: PANTHER Pathway Component

ncbitaxon 9544 13
type: UnificationXref
id: 9544
db: ncbitaxon

1,25 dihydroxyvitamin D s4 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 1,25-dihydroxyvitamin D
stoichiometric coefficient: 1.0

P04600
type: UnificationXref
id: P04600
db: PANTHER Pathway Component

P04601
type: UnificationXref
id: P04601
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR11385:SF11
xref: uniprot F6WR34 12
organism: Macaca mulatta

VDR s22 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VDR
stoichiometric coefficient: 1.0

Uncharacterized protein
type: DnaReference
xref: PTHR24291:SF5
organism: Macaca mulatta

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 4

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 55

UV light
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

1alpha-Hydroxylase
type: Protein
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

FDX
type: Protein
feature: ACTIVE 76
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7165 60
type: UnificationXref
id: 7165
db: ncbitaxon

Retinoic acid receptor RXR-alpha
type: ProteinReference
xref: uniprot P19793 36
organism: Homo sapiens

25-hydroxyvitamin D
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=SIMPLE_MOLECULE

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot Q3SYT8 58
type: UnificationXref
id: Q3SYT8
db: uniprot

mitochondrion
type: CellularLocationVocabulary
xref: GO GO:0005739 3

VDR
type: Protein
entity reference: VDR
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa4 84
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P36587 51
type: UnificationXref
id: P36587
db: uniprot

FdxR
type: Protein
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

Skin c5
type: CellularLocationVocabulary
comment: Skin

HETERODIMER_ASSOCIATION_LEFT__VDR-_1,25_dihydroxyvitamin_D3-RIGHT__Complex__1,25_dihydroxyvitamin_D_Vitamin_D_Receptor_-_re12
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 124
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 122
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 123
left: VDR
left: 1,25-dihydroxyvitamin D3
interaction type: HETERODIMER_ASSOCIATION
right: Complex (1,25-dihydroxyvitamin D/Vitamin D Receptor)

25-Hydroxylase
type: Protein
entity reference: 25-Hydroxylase
cellular location: liver c6
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION_LEFT__VDRE-RIGHT__VDRE-_re36
type: TemplateReaction
product: VDRE
xref: TRANSCRIPTION
participant: VDRE
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

STATE_TRANSITION_LEFT__FDX-_NADPH-RIGHT__NADP_PLUS_-_FDX-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 99
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 100
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 98
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 97
left: FDX
left: NADPH
interaction type: STATE_TRANSITION
right: FDX
right: NADP+

Complex (1,25-dihydroxyvitamin D/Vitamin D Receptor)
type: Complex
component stoichiometry: VDR s14 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: 1,25 dihydroxyvitamin D s13 sa3 STOICHIOMETRY ID COMPLEX
component: 1,25-dihydroxyvitamin D
component: VDR
feature: ACTIVE 76
feature: COMPLEX BINDING FEATURE s24 a28 81
feature: COMPLEX BINDING FEATURE s24 a28 83
cellular location: nucleus

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
type: DnaReference
xref: PTHR24291:SF5
organism: Rattus norvegicus

CYP27A1 isoform 1
type: ProteinReference
xref: uniprot K7CD19 63
xref: PTHR24291:SF6
organism: Pan troglodytes

Retinoic acid receptor alpha-B
type: ProteinReference
xref: uniprot Q7ZTI3 41
organism: Danio rerio