PTHR24356:SF303
type: RelationshipXref
id: PTHR24356:SF303
db: PANTHER Family
relationship type: By Homology

uniprot Q96MU8 1904
type: UnificationXref
id: Q96MU8
db: uniprot

Serine/threonine protein kinase
type: ProteinReference
xref: PTHR11909:SF391
xref: uniprot Q8W1K7 1856
organism: 3055

Protocadherin beta-16
type: ProteinReference
xref: PTHR24028:SF71
xref: uniprot Q9NRJ7 944
organism: Homo sapiens

Dachsous cadherin-related 1
type: ProteinReference
xref: PTHR24027:SF423
xref: uniprot A0A2I3TID8 643
organism: Pan troglodytes

uniprot P16298 1324
type: UnificationXref
id: P16298
db: uniprot

ncbitaxon 185431 1766
type: UnificationXref
id: 185431
db: ncbitaxon

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot Q28IC7 1257
organism: Xenopus tropicalis

Uncharacterized protein
type: DnaReference
xref: PTHR11937:SF150
organism: 9258

Frizzled-2
type: ProteinReference
xref: uniprot Q08464 120
xref: PTHR11309:SF34
organism: Rattus norvegicus

Casein kinase II, putative
type: ProteinReference
xref: uniprot Q38D21 1765
xref: PTHR24054:SF46
organism: Trypanosoma brucei

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot Q08463 119
organism: Rattus norvegicus

uniprot P51028 1246
type: UnificationXref
id: P51028
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F7EV26 1189
xref: PTHR12027:SF7
organism: Macaca mulatta

uniprot F1MHH5 704
type: UnificationXref
id: F1MHH5
db: uniprot

uniprot O88566 164
type: UnificationXref
id: O88566
db: uniprot

AGAP010134-PA
type: ProteinReference
xref: uniprot Q95NF3 1591
xref: PTHR11792:SF16
organism: Anopheles gambiae

Casein kinase 1 delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot F1Q126 1796
organism: Canis lupus familiaris

Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
type: ProteinReference
xref: uniprot Q5RKP9 1466
xref: PTHR10218:SF328
organism: Danio rerio

uniprot Q8H386 1776
type: UnificationXref
id: Q8H386
db: uniprot

uniprot E2QWQ2 1421
type: UnificationXref
id: E2QWQ2
db: uniprot

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot P68399 1761
xref: PTHR24054:SF16
organism: Bos taurus

PTHR10218:SF316
type: RelationshipXref
id: PTHR10218:SF316
db: PANTHER Family
relationship type: By Homology

Complex (TCF/Smad4/ Beta-Catenin)
type: Complex
component stoichiometry: Smad4 s80 sa51 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCF s79 sa50 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Catenin s82 sa52 STOICHIOMETRY ID COMPLEX
component: Beta-Catenin
component: TCF s79 sa50
component: Smad4
feature: COMPLEX BINDING FEATURE s176 a403 2239
feature: ACTIVE 50
feature: COMPLEX BINDING FEATURE s176 a403 2243
feature: COMPLEX BINDING FEATURE s176 a403 2241
cellular location: nucleus

uniprot Q5T4F7 239
type: UnificationXref
id: Q5T4F7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24028:SF258
xref: uniprot F6S1W0 721
organism: Macaca mulatta

uniprot G3X6Y5 784
type: UnificationXref
id: G3X6Y5
db: uniprot

uniprot E2QY91 1379
type: UnificationXref
id: E2QY91
db: uniprot

Secreted frizzled-related protein 2
type: ProteinReference
xref: PTHR11309:SF45
xref: uniprot P97299 237
organism: Mus musculus

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 1343

Probable chromatin-remodeling complex ATPase chain
type: ProteinReference
xref: uniprot Q7G8Y3 405
xref: PTHR10799:SF879
organism: Oryza sativa

Protocadherin 8
type: ProteinReference
xref: PTHR24028:SF46
xref: uniprot H2Q7M1 786
organism: Pan troglodytes

Cadherin-8
type: ProteinReference
xref: uniprot P97291 840
xref: PTHR24027:SF273
organism: Mus musculus

uniprot H2R3A6 1616
type: UnificationXref
id: H2R3A6
db: uniprot

PP2A s180 sa97 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF81
xref: uniprot F7E6I8 758
organism: Monodelphis domestica

PTHR10218:SF328
type: RelationshipXref
id: PTHR10218:SF328
db: PANTHER Family
relationship type: By Homology

PTHR10218:SF329
type: RelationshipXref
id: PTHR10218:SF329
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF347
type: RelationshipXref
id: PTHR24356:SF347
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot F7CTP1 1610
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR18914:SF24
xref: uniprot E1C7M7 2013
organism: 9031

MMP7 isoform 1
type: DnaReference
xref: PTHR10201:SF143
organism: Pan troglodytes

Frizzled class receptor 2
type: ProteinReference
xref: uniprot F6SH04 91
xref: PTHR11309:SF34
organism: Xenopus tropicalis

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot B3DJ37 1036
organism: Danio rerio

Serine/threonine-protein kinase NLK
type: ProteinReference
xref: uniprot D3ZSZ3 1420
xref: PTHR24055:SF380
organism: Rattus norvegicus

uniprot Q9R0M0 949
type: UnificationXref
id: Q9R0M0
db: uniprot

Protocadherin b
type: ProteinReference
xref: uniprot E7FAU6 687
organism: Danio rerio

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot D4A9D7 1157
organism: Rattus norvegicus

uniprot E2QXQ3 1162
type: UnificationXref
id: E2QXQ3
db: uniprot

Frizzled class receptor 2
type: ProteinReference
xref: uniprot G3N2W8 102
xref: PTHR11309:SF34
organism: Bos taurus

uniprot F7G1U7 1448
type: UnificationXref
id: F7G1U7
db: uniprot

Frizzled class receptor 7a
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot Q6NV44 131
organism: Danio rerio

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Saccharomyces cerevisiae

uniprot F7DGM2 755
type: UnificationXref
id: F7DGM2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GJC2 767
xref: PTHR24027:SF419
organism: Macaca mulatta

uniprot F1MYU1 290
type: UnificationXref
id: F1MYU1
db: uniprot

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
type: ProteinReference
xref: uniprot F7DUC5 313
xref: PTHR10799:SF879
organism: 9258

uniprot Q69ZU8 1994
type: UnificationXref
id: Q69ZU8
db: uniprot

uniprot F6TBG4 1800
type: UnificationXref
id: F6TBG4
db: uniprot

Helicase domino
type: ProteinReference
xref: uniprot Q9NDJ2 436
xref: PTHR45685:SF1
organism: Drosophila melanogaster

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A5D7T5 1300
xref: PTHR45673:SF2
organism: Bos taurus

PTHR15919:SF12
type: RelationshipXref
id: PTHR15919:SF12
db: PANTHER Family
relationship type: By Homology

uniprot Q803G3 593
type: UnificationXref
id: Q803G3
db: uniprot

AGAP010442-PA
type: ProteinReference
xref: uniprot Q7QDV6 133
xref: PTHR11309:SF126
organism: Anopheles gambiae

uniprot O75581 181
type: UnificationXref
id: O75581
db: uniprot

uniprot Q32PJ8 2084
type: UnificationXref
id: Q32PJ8
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q9QW07 1121
organism: Rattus norvegicus

PTHR10625:SF192
type: RelationshipXref
id: PTHR10625:SF192
db: PANTHER Family
relationship type: By Homology

Casein Kinase 1 s49 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Casein Kinase 1
stoichiometric coefficient: 1.0

PTHR10625:SF194
type: RelationshipXref
id: PTHR10625:SF194
db: PANTHER Family
relationship type: By Homology

uniprot F1MAH6 701
type: UnificationXref
id: F1MAH6
db: uniprot

CDH16 isoform 1
type: ProteinReference
xref: uniprot A0A2I3RN05 635
xref: PTHR24028:SF1
organism: Pan troglodytes

uniprot D4A7D6 1431
type: UnificationXref
id: D4A7D6
db: uniprot

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

S-arrestin
type: ProteinReference
xref: PTHR11792:SF15
xref: uniprot P10523 1574
organism: Homo sapiens

Chico
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot Q9PTS6 496
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF322
xref: uniprot F6Y191 738
organism: Monodelphis domestica

uniprot A0A2I3RVF5 638
type: UnificationXref
id: A0A2I3RVF5
db: uniprot

FAT atypical cadherin 1
type: ProteinReference
xref: uniprot A0A0G2K5L1 620
xref: PTHR24026:SF42
organism: Rattus norvegicus

uniprot F6WI86 735
type: UnificationXref
id: F6WI86
db: uniprot

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Mycobacterium tuberculosis

Secreted frizzled-related sequence protein 4
type: ProteinReference
xref: uniprot Q9Z1N6 1894
xref: PTHR11309:SF7
organism: Mus musculus

PTHR10625:SF185
type: RelationshipXref
id: PTHR10625:SF185
db: PANTHER Family
relationship type: By Homology

uniprot P22727 1229
type: UnificationXref
id: P22727
db: uniprot

PTHR10625:SF188
type: RelationshipXref
id: PTHR10625:SF188
db: PANTHER Family
relationship type: By Homology

Galpha
type: Protein
entity reference: Galpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s163 sa79 2350
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot O43318 1064
type: UnificationXref
id: O43318
db: uniprot

uniprot F1NFY6 2051
type: UnificationXref
id: F1NFY6
db: uniprot

uniprot A0A2R8RWN9 1516
type: UnificationXref
id: A0A2R8RWN9
db: uniprot

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b
type: ProteinReference
xref: uniprot A0A0G2JTY4 1469
xref: PTHR12533:SF6
organism: Rattus norvegicus

PTHR12027:SF89
type: RelationshipXref
id: PTHR12027:SF89
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF88
type: RelationshipXref
id: PTHR12027:SF88
db: PANTHER Family
relationship type: By Homology

uniprot Q06900 1077
type: UnificationXref
id: Q06900
db: uniprot

PTHR12027:SF87
type: RelationshipXref
id: PTHR12027:SF87
db: PANTHER Family
relationship type: By Homology

FRZB isoform 1
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot H2QJ36 1883
organism: Pan troglodytes

PTHR12027:SF92
type: RelationshipXref
id: PTHR12027:SF92
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF93
type: RelationshipXref
id: PTHR12027:SF93
db: PANTHER Family
relationship type: By Homology

Calcineurin subunit B type 1
type: ProteinReference
xref: uniprot Q55G87 1355
xref: PTHR45942:SF1
organism: Dictyostelium discoideum

PTHR12027:SF91
type: RelationshipXref
id: PTHR12027:SF91
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF81
xref: uniprot F7DGM2 755
organism: Macaca mulatta

Protein Wnt-11
type: ProteinReference
xref: PTHR12027:SF34
xref: uniprot O73864 1218
organism: Danio rerio

PTHR12027:SF94
type: RelationshipXref
id: PTHR12027:SF94
db: PANTHER Family
relationship type: By Homology

Kremen protein
type: ProteinReference
xref: uniprot F7FIC8 1899
organism: Macaca mulatta

uniprot Q5DWV1 867
type: UnificationXref
id: Q5DWV1
db: uniprot

Myosin-6
type: DnaReference
xref: PTHR45615:SF11
organism: Mus musculus

PTHR12027:SF98
type: RelationshipXref
id: PTHR12027:SF98
db: PANTHER Family
relationship type: By Homology

Myc proto-oncogene protein
type: DnaReference
xref: PTHR45851:SF1
organism: Mus musculus

ncbitaxon 3218 1715
type: UnificationXref
id: 3218
db: ncbitaxon

uniprot P48451 1329
type: UnificationXref
id: P48451
db: uniprot

Discs overgrown protein kinase
type: ProteinReference
xref: uniprot O76324 1813
xref: PTHR11909:SF18
organism: Drosophila melanogaster

Nuclear factor of activated T-cells, cytoplasmic 3
type: ProteinReference
xref: PTHR12533:SF6
xref: uniprot Q12968 1484
organism: Homo sapiens

DISSOCIATION_LEFT__Complex__Beta_Catenin_Cadherin__alpha_Catenin_-RIGHT__alpha_Catenin-_Complex__Beta_Catenin_Cadherin_-_r100
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 2520
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 2519
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 2521
left: Complex Beta Catenin Cadherin alpha Catenin s282 a587
interaction type: DISSOCIATION
right: alpha-Catenin
right: Complex (Beta-Catenin/Cadherin)

PTHR46716:SF1
type: RelationshipXref
id: PTHR46716:SF1
db: PANTHER Family
relationship type: By Homology

uniprot K7CBH8 1671
type: UnificationXref
id: K7CBH8
db: uniprot

uniprot P15372 1575
type: UnificationXref
id: P15372
db: uniprot

uniprot F7EV26 1189
type: UnificationXref
id: F7EV26
db: uniprot

Cadherin-2
type: ProteinReference
xref: PTHR24027:SF79
xref: uniprot Q9Z1Y3 1009
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r71 2426
type: Stoichiometry
physical entity: Nemo-like Kinase
stoichiometric coefficient: 1.0

Protocadherin Fat 2
type: ProteinReference
xref: uniprot Q5F226 869
xref: PTHR24026:SF37
organism: Mus musculus

Cadherin 18
type: ProteinReference
xref: PTHR24027:SF106
xref: uniprot F7ABP2 745
organism: Monodelphis domestica

uniprot O13166 479
type: UnificationXref
id: O13166
db: uniprot

Glycogen Synthase Kinase 3Beta s204 sa110 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glycogen Synthase Kinase 3Beta s204 sa110
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF84
xref: uniprot F7H7P6 1192
organism: Macaca mulatta

uniprot Q7PRH5 406
type: UnificationXref
id: Q7PRH5
db: uniprot

PARTICIPANT STOICHIOMETRY r71 2425
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 2424
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot F7HTC6 606
type: UnificationXref
id: F7HTC6
db: uniprot

uniprot P09217 1679
type: UnificationXref
id: P09217
db: uniprot

PARTICIPANT STOICHIOMETRY r71 2423
type: Stoichiometry
physical entity: Nemo like Kinase s196 a455
stoichiometric coefficient: 1.0

uniprot E2RJ59 1306
type: UnificationXref
id: E2RJ59
db: uniprot

PTHR12027:SF75
type: RelationshipXref
id: PTHR12027:SF75
db: PANTHER Family
relationship type: By Homology

uniprot P67827 1829
type: UnificationXref
id: P67827
db: uniprot

PTHR12027:SF72
type: RelationshipXref
id: PTHR12027:SF72
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF73
type: RelationshipXref
id: PTHR12027:SF73
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF70
type: RelationshipXref
id: PTHR12027:SF70
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7H808 557
xref: PTHR45619:SF42
organism: Macaca mulatta

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50150 1961
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 1962
xref: PTHR13809:SF6
organism: Homo sapiens

uniprot A0A1D5QHG9 629
type: UnificationXref
id: A0A1D5QHG9
db: uniprot

PTHR12027:SF77
type: RelationshipXref
id: PTHR12027:SF77
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF76
type: RelationshipXref
id: PTHR12027:SF76
db: PANTHER Family
relationship type: By Homology

uniprot O60330 806
type: UnificationXref
id: O60330
db: uniprot

PTHR12027:SF78
type: RelationshipXref
id: PTHR12027:SF78
db: PANTHER Family
relationship type: By Homology

Casein kinase II subunit beta'
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot O96863 1742
organism: Drosophila melanogaster

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50153 1963
organism: Mus musculus

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P50148 1462
organism: Homo sapiens

PTHR12027:SF84
type: RelationshipXref
id: PTHR12027:SF84
db: PANTHER Family
relationship type: By Homology

Dishevelled segment polarity protein 2
type: ProteinReference
xref: uniprot E2R7K2 1380
xref: PTHR10878:SF8
organism: Canis lupus familiaris

PTHR12027:SF86
type: RelationshipXref
id: PTHR12027:SF86
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E7F1L8 1422
xref: PTHR24055:SF380
organism: Danio rerio

G protein subunit gamma 13
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot E2R7K4 1923
organism: Canis lupus familiaris

Myosin, heavy chain b
type: DnaReference
xref: PTHR45615:SF44
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r48 2396
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Axin/ Diversin/Beta-Catenin/ PP2A)
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF82
xref: uniprot F7H7P8 1193
organism: Macaca mulatta

HETERODIMER_ASSOCIATION_LEFT__Phospholipase_C-_Galpha-RIGHT__Complex__Galpha_Phospholipase_C_-_r72
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 2420
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 2422
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 2421
left: Phospholipase C
left: Galpha
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Galpha/Phospholipase C)

PTHR12027:SF81
type: RelationshipXref
id: PTHR12027:SF81
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r48 2394
type: Stoichiometry
physical entity: Diversin
stoichiometric coefficient: 1.0

PTHR12027:SF82
type: RelationshipXref
id: PTHR12027:SF82
db: PANTHER Family
relationship type: By Homology

uniprot A0A0K3AWM6 63
type: UnificationXref
id: A0A0K3AWM6
db: uniprot

uniprot Q62440 492
type: UnificationXref
id: Q62440
db: uniprot

PARTICIPANT STOICHIOMETRY r48 2395
type: Stoichiometry
physical entity: Complex Adenomatous Polyposis Coli Axin Beta Catenin PP2A s123 a275
stoichiometric coefficient: 1.0

uniprot Q7ZU33 1774
type: UnificationXref
id: Q7ZU33
db: uniprot

PTHR10625:SF132
type: RelationshipXref
id: PTHR10625:SF132
db: PANTHER Family
relationship type: By Homology

Actin, cytoplasmic 2
type: DnaReference
xref: PTHR11937:SF192
organism: Xenopus tropicalis

Developmental myosin heavy chain embryonic
type: DnaReference
xref: PTHR45615:SF6
organism: Canis lupus familiaris

uniprot Q9FYH1 1416
type: UnificationXref
id: Q9FYH1
db: uniprot

PTHR45976:SF4
type: RelationshipXref
id: PTHR45976:SF4
db: PANTHER Family
relationship type: By Homology

NFAT
type: Protein
entity reference: NFAT PROTEIN
feature: NFAT s230 a494 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Beta Catenin s64 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot A0A3Q2U0G2 1092
organism: 9031

PTHR24027:SF322
type: RelationshipXref
id: PTHR24027:SF322
db: PANTHER Family
relationship type: By Homology

PTHR24027:SF323
type: RelationshipXref
id: PTHR24027:SF323
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: uniprot Q9DEB8 1273
xref: PTHR12027:SF78
organism: 9031

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot H2QIU8 1060
organism: Pan troglodytes

Casein kinase I isoform gamma-2
type: ProteinReference
xref: PTHR11909:SF157
xref: uniprot Q8BVP5 1847
organism: Mus musculus

uniprot Q7PW25 1117
type: UnificationXref
id: Q7PW25
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot A6H6X8 1138
organism: Bos taurus

Lymphoid enhancer-binding factor 1
type: ProteinReference
xref: PTHR10373:SF11
xref: uniprot P27782 511
organism: Mus musculus

Peroxisome proliferator-activated receptor delta
type: DnaReference
xref: PTHR24082:SF15
organism: Canis lupus familiaris

alpha-Catenin
type: Protein
entity reference: alpha-Catenin
feature: COMPLEX PARTICIPANT BINDING FEATURE s140 sa125 2344
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Axin
type: ProteinReference
xref: P01429
standard name: Axis inhibitor 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Axin
comment: ENTITY_REFERENCE_NOTES= Long Name: Axin Synonym: Axis Inhibitor Protein,Conductin Accession: P01429
member entity reference: Axin-1
member entity reference: O70240
member entity reference: Axin 1
member entity reference: O88566
member entity reference: AGAP002123-PA
member entity reference: O70239
member entity reference: Axin-2
member entity reference: Axin 2
member entity reference: Uncharacterized protein
member entity reference: O35625

Mothers against decapentaplegic homolog 5
type: ProteinReference
xref: PTHR13703:SF36
xref: uniprot Q99717 1556
organism: Homo sapiens

ARID1A isoform 3
type: ProteinReference
xref: PTHR12656:SF12
xref: uniprot K6ZTZ3 339
organism: Pan troglodytes

Protein Wnt
type: ProteinReference
xref: uniprot D4A9J2 1158
xref: PTHR12027:SF91
organism: Rattus norvegicus

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r111
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 2450
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 2449
left: Ca2+
interaction type: TRANSPORT
right: Ca2 PLUS s294 a618

uniprot D3ZBS9 270
type: UnificationXref
id: D3ZBS9
db: uniprot

G01559
type: UnificationXref
id: G01559
db: PANTHER Pathway Component

G01558
type: UnificationXref
id: G01558
db: PANTHER Pathway Component

uniprot F6ZBJ4 508
type: UnificationXref
id: F6ZBJ4
db: uniprot

uniprot F1PDD9 1477
type: UnificationXref
id: F1PDD9
db: uniprot

PTHR12027:SF33
type: RelationshipXref
id: PTHR12027:SF33
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF34
type: RelationshipXref
id: PTHR12027:SF34
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10373:SF11
xref: uniprot A0A1D5REM7 499
organism: Macaca mulatta

Pygopus family PHD finger 1
type: ProteinReference
xref: uniprot F1Q0S3 1909
xref: PTHR23194:SF3
organism: Canis lupus familiaris

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: 284812

Protein Wnt-10a
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot P70701 1253
organism: Mus musculus

PTHR10625:SF109
type: RelationshipXref
id: PTHR10625:SF109
db: PANTHER Family
relationship type: By Homology

uniprot F7BUJ8 749
type: UnificationXref
id: F7BUJ8
db: uniprot

Threonine41 Beta Catenin s270 a146 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s270 a146 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

uniprot P54367 1828
type: UnificationXref
id: P54367
db: uniprot

PTHR24027:SF419
type: RelationshipXref
id: PTHR24027:SF419
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TID8 643
type: UnificationXref
id: A0A2I3TID8
db: uniprot

uniprot P28047 1233
type: UnificationXref
id: P28047
db: uniprot

Protocadherin beta-9
type: ProteinReference
xref: uniprot Q5DRC4 854
xref: PTHR24028:SF128
organism: Pan troglodytes

Frodo
type: Protein
entity reference: Frodo PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s148 sa133 2298
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protocadherin beta-7
type: ProteinReference
xref: PTHR24028:SF69
xref: uniprot Q5DRC7 856
organism: Pan troglodytes

Diversin
type: Protein
entity reference: Diversin
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

AGAP009716-PA (Fragment)
type: ProteinReference
xref: PTHR24027:SF422
xref: uniprot Q7Q1M9 883
organism: Anopheles gambiae

Protocadherin beta-8
type: ProteinReference
xref: uniprot Q5DRC6 855
xref: PTHR24028:SF150
organism: Pan troglodytes

Bcl9 s87 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Bcl9
stoichiometric coefficient: 1.0

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 1302

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot E2QW66 1037
organism: Canis lupus familiaris

TCF7L1 isoform 2
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot H2QI87 510
organism: Pan troglodytes

Lymphoid-specific helicase
type: ProteinReference
xref: uniprot Q9NRZ9 437
xref: PTHR47161:SF1
organism: Homo sapiens

B-cell CLL/lymphoma 9 protein
type: ProteinReference
xref: PTHR15185:SF5
xref: uniprot F7D4Z2 1434
organism: Macaca mulatta

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Beta Catenin s92 sa62 rs5
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa62 2254
feature: Threonine41 Beta Catenin s92 sa62 rs4
feature: Serine35 Beta Catenin s92 sa62 rs2
feature: Serine45 Beta Catenin s92 sa62 rs1
feature: serine33 Beta Catenin s92 sa62 rs3
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot Q3SZ98 1977
organism: Bos taurus

uniprot H2Q058 1912
type: UnificationXref
id: H2Q058
db: uniprot

uniprot F6Q2D0 229
type: UnificationXref
id: F6Q2D0
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot A0A0G2JTA1 521
organism: Rattus norvegicus

Histone deacetylase 1
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot O17695 2068
organism: Caenorhabditis elegans

eco ECO:0000501 882
type: UnificationXref
id: ECO:0000501
db: eco

Cadherin
type: ProteinReference
xref: P01440
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Cadherin
comment: ENTITY_REFERENCE_NOTES= Long Name: Cadherin Synonym: Synonym not specified Accession: P01440
member entity reference: Q91Y06
member entity reference: Protocadherin 10
member entity reference: Fat protein
member entity reference: Protocadherin alpha-2
member entity reference: Cadherin-9
member entity reference: Cadherin 11
member entity reference: Protocadherin-7
member entity reference: Uncharacterized protein
member entity reference: Protocadherin beta 3
member entity reference: MCG141285
member entity reference: Protocadherin beta 14
member entity reference: Cadherin-related hmr-1
member entity reference: Cadherin-10
member entity reference: Cadherin 3
member entity reference: Cadherin-24
member entity reference: Protocadherin gamma-C5
member entity reference: Cadherin 13
member entity reference: Protocadherin-11 X-linked
member entity reference: Q91XZ5
member entity reference: CDH5 isoform 1
member entity reference: Cadherin 9
member entity reference: FAT atypical cadherin 1
member entity reference: Protocadherin beta-2
member entity reference: Protocadherin gamma-A5
member entity reference: Protocadherin Fat 3
member entity reference: D3ZFQ5
member entity reference: O15943
member entity reference: Cadherin-18
member entity reference: Protocadherin beta-6
member entity reference: Protocadherin 19
member entity reference: Protocadherin-16
member entity reference: Cadherin-2
member entity reference: Protocadherin 11 X-linked (Predicted)
member entity reference: A0A2J8NDG6
member entity reference: Cadherin-7
member entity reference: Cadherin 4
member entity reference: Cadherin-3
member entity reference: Protocadherin-9
member entity reference: Cadherin-related family member 1
member entity reference: Q9NYQ7
member entity reference: Protocadherin 12
member entity reference: Cadherin 1, type 1, E-cadherin (epithelial)
member entity reference: Q9NYQ6
member entity reference: Cadherin 5
member entity reference: Cadherin 74A, isoform A
member entity reference: Protocadherin beta-14
member entity reference: Cadherin 18
member entity reference: Cadherin-22
member entity reference: Protocadherin gamma-A2
member entity reference: Cadherin 6, type 2, K-cadherin (Fetal kidney)
member entity reference: Cadherin 2
member entity reference: Dachsous cadherin-related 1
member entity reference: Cadherin 7
member entity reference: Protocadherin 1
member entity reference: F7D992
member entity reference: P33146
member entity reference: Protocadherin beta-8
member entity reference: Cadherin-20
member entity reference: Q91VE5
member entity reference: Q91Y02
member entity reference: Protocadherin 7
member entity reference: F7C1R7
member entity reference: Protocadherin-20
member entity reference: Protocadherin beta-9
member entity reference: Cadherin-13

Protocadherin gamma-A7
type: ProteinReference
xref: PTHR24028:SF56
xref: uniprot Q5DRB3 853
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q2V8 627
xref: PTHR24028:SF11
organism: Macaca mulatta

Protein Kinase C
type: Protein
entity reference: Protein Kinase C
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
type: ProteinReference
xref: uniprot F6THW2 1444
xref: PTHR10218:SF328
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q377 453
xref: PTHR10814:SF29
organism: Macaca mulatta

uniprot F7C6H2 1317
type: UnificationXref
id: F7C6H2
db: uniprot

Actin, alpha cardiac muscle 1
type: DnaReference
xref: PTHR11937:SF176
organism: Mus musculus

uniprot Q91Y06 924
type: UnificationXref
id: Q91Y06
db: uniprot

SWF/SNF family helicase
type: ProteinReference
xref: uniprot O84714 350
xref: PTHR10799:SF923
organism: Chlamydia trachomatis

CDHR1 isoform 1
type: ProteinReference
xref: PTHR24028:SF263
xref: uniprot A0A2J8KIM7 646
organism: Pan troglodytes

Actin, alpha skeletal muscle
type: DnaReference
xref: PTHR11937:SF193
organism: Mus musculus

Actin, aortic smooth muscle
type: DnaReference
xref: PTHR11937:SF201
organism: Mus musculus

Cadherin 12
type: ProteinReference
xref: PTHR24027:SF96
xref: uniprot F6VEV5 731
organism: 9258

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot A0A2I3TI13 1131
organism: Pan troglodytes

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot B7QIS2 1719
xref: PTHR11740:SF0
organism: Ixodes scapularis

Protocadherin beta-10
type: ProteinReference
xref: uniprot Q5DRD9 864
xref: PTHR24028:SF54
organism: Pan troglodytes

uniprot Q9UTN6 445
type: UnificationXref
id: Q9UTN6
db: uniprot

NFAT
type: Protein
entity reference: NFAT PROTEIN
feature: NFAT s229 a495 rs1
feature: ACTIVE 50
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F1QGH7 187
type: UnificationXref
id: F1QGH7
db: uniprot

uniprot F6UBJ7 723
type: UnificationXref
id: F6UBJ7
db: uniprot

Frizzled class receptor 3
type: ProteinReference
xref: uniprot F6RPG1 90
xref: PTHR11309:SF22
organism: Xenopus tropicalis

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9Z1B3 1123
xref: PTHR10336:SF12
organism: Mus musculus

uniprot Q9UN71 958
type: UnificationXref
id: Q9UN71
db: uniprot

uniprot A7RPJ6 1791
type: UnificationXref
id: A7RPJ6
db: uniprot

uniprot F7HGC0 2021
type: UnificationXref
id: F7HGC0
db: uniprot

Protocadherin beta-1
type: ProteinReference
xref: uniprot Q5DRE0 865
xref: PTHR24028:SF12
organism: Pan troglodytes

Protein Kinase C
type: Protein
entity reference: Protein Kinase C
feature: ACTIVE 50
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Y5H0 992
type: UnificationXref
id: Q9Y5H0
db: uniprot

PTHR24027:SF425
type: RelationshipXref
id: PTHR24027:SF425
db: PANTHER Family
relationship type: By Homology

uniprot F6Z7T2 1479
type: UnificationXref
id: F6Z7T2
db: uniprot

PTHR24027:SF423
type: RelationshipXref
id: PTHR24027:SF423
db: PANTHER Family
relationship type: By Homology

PTHR24027:SF422
type: RelationshipXref
id: PTHR24027:SF422
db: PANTHER Family
relationship type: By Homology

Protocadherin beta-6
type: ProteinReference
xref: PTHR24028:SF104
xref: uniprot Q5DRC8 857
organism: Pan troglodytes

Protocadherin beta-11
type: ProteinReference
xref: PTHR24028:SF286
xref: uniprot Q5DRD8 863
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 1956
xref: PTHR13809:SF6
organism: Pan troglodytes

Protocadherin beta-12
type: ProteinReference
xref: PTHR24028:SF91
xref: uniprot Q5DRD7 862
organism: Pan troglodytes

Protocadherin beta-13
type: ProteinReference
xref: uniprot Q5DRD6 861
xref: PTHR24028:SF61
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 1601
xref: PTHR19850:SF28
organism: 9031

Protocadherin beta-15
type: ProteinReference
xref: PTHR24028:SF97
xref: uniprot Q5DRD3 860
organism: Pan troglodytes

uniprot F5HLK4 1312
type: UnificationXref
id: F5HLK4
db: uniprot

Protocadherin beta-2
type: ProteinReference
xref: uniprot Q5DRD2 859
xref: PTHR24028:SF281
organism: Pan troglodytes

Protocadherin beta-3
type: ProteinReference
xref: PTHR24028:SF118
xref: uniprot Q5DRD1 858
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q352 628
xref: PTHR24028:SF254
organism: Macaca mulatta

Cadherin 10
type: ProteinReference
xref: PTHR24027:SF290
xref: uniprot E2R858 682
organism: Canis lupus familiaris

uniprot A7MB15 70
type: UnificationXref
id: A7MB15
db: uniprot

TGF-beta receptor type-1
type: ProteinReference
xref: uniprot P80204 1076
organism: Rattus norvegicus

Cadherin-18
type: ProteinReference
xref: PTHR24027:SF106
xref: uniprot Q13634 845
organism: Homo sapiens

Activin receptor type-1B
type: ProteinReference
xref: uniprot P80202 1075
organism: Rattus norvegicus

uniprot Q9ULG1 444
type: UnificationXref
id: Q9ULG1
db: uniprot

uniprot Q27886 1256
type: UnificationXref
id: Q27886
db: uniprot

Cadherin 10
type: ProteinReference
xref: uniprot F6VET9 730
xref: PTHR24027:SF290
organism: 9258

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 1088

Adenomatous Polyposis Coli s305 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli
stoichiometric coefficient: 1.0

uniprot Q9VFH5 966
type: UnificationXref
id: Q9VFH5
db: uniprot

Pygopus homolog 2
type: ProteinReference
xref: PTHR23194:SF7
xref: uniprot Q9BRQ0 1914
organism: Homo sapiens

Myosin heavy chain 2
type: DnaReference
xref: PTHR45615:SF39
organism: Pan troglodytes

uniprot A0A0G2JVE0 1511
type: UnificationXref
id: A0A0G2JVE0
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR45615:SF3
organism: Pan troglodytes

uniprot F6SRK5 188
type: UnificationXref
id: F6SRK5
db: uniprot

uniprot H2QI87 510
type: UnificationXref
id: H2QI87
db: uniprot

Myosin heavy chain 13
type: DnaReference
xref: PTHR45615:SF44
organism: Pan troglodytes

uniprot A8WV58 1140
type: UnificationXref
id: A8WV58
db: uniprot

uniprot P30671 1959
type: UnificationXref
id: P30671
db: uniprot

MYH4 isoform 1
type: DnaReference
xref: PTHR45615:SF2
organism: Pan troglodytes

Uncharacterized protein
type: DnaReference
xref: PTHR45615:SF35
organism: Pan troglodytes

uniprot Q7PMD1 1980
type: UnificationXref
id: Q7PMD1
db: uniprot

uniprot P55280 825
type: UnificationXref
id: P55280
db: uniprot

ncbitaxon 6669 1308
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot Q9BL39 431
type: UnificationXref
id: Q9BL39
db: uniprot

uniprot Q61089 127
type: UnificationXref
id: Q61089
db: uniprot

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot P38408 1460
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P38409 1461
organism: Bos taurus

uniprot Q62073 1082
type: UnificationXref
id: Q62073
db: uniprot

Complex (Adenomatous Polyposis Coli/Axin/ Diversin/Casein Kinase 1/ Glycogen Synthase Kinase-3Beta/PP2A)
type: Complex
component stoichiometry: Adenomatous Polyposis Coli s44 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: Axin s47 sa32 STOICHIOMETRY ID COMPLEX
component stoichiometry: PP2A s51 sa36 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glycogen Synthase Kinase 3Beta s50 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: Diversin s48 sa33 STOICHIOMETRY ID COMPLEX
component stoichiometry: Casein Kinase 1 s49 sa34 STOICHIOMETRY ID COMPLEX
component: PP2A
component: Casein Kinase 1
component: Glycogen Synthase Kinase 3Beta s50 sa35
component: Diversin
component: Adenomatous Polyposis Coli
component: Axin
feature: COMPLEX BINDING FEATURE s155 a356 2181
feature: COMPLEX BINDING FEATURE s155 a356 2175
feature: COMPLEX BINDING FEATURE s155 a356 2177
feature: COMPLEX BINDING FEATURE s155 a356 2173
feature: COMPLEX BINDING FEATURE s155 a356 2183
feature: COMPLEX BINDING FEATURE s155 a356 2179
cellular location: plasma membrane

uniprot Q8QFM3 137
type: UnificationXref
id: Q8QFM3
db: uniprot

Adenylosuccinate synthetase isozyme 2
type: DnaReference
xref: PTHR11846:SF13
organism: Mus musculus

Adenylosuccinate synthetase isozyme 1
type: DnaReference
xref: PTHR11846:SF2
organism: Mus musculus

uniprot Q9Y5H7 999
type: UnificationXref
id: Q9Y5H7
db: uniprot

uniprot F7BIC2 1662
type: UnificationXref
id: F7BIC2
db: uniprot

Protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b
type: ProteinReference
xref: uniprot Q66HZ0 1359
xref: PTHR45942:SF1
organism: Danio rerio

Diversin s191 sa106 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Diversin
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot Q9UK08 1989
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor
type: ProteinReference
xref: PTHR13715:SF87
xref: uniprot P29993 34
organism: Drosophila melanogaster

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A2VDZ0 528
xref: PTHR10257:SF6
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P29992 1456
xref: PTHR10218:SF328
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot P29995 38
xref: PTHR13715:SF53
organism: Rattus norvegicus

uniprot Q05681 1344
type: UnificationXref
id: Q05681
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P29994 36
organism: Rattus norvegicus

Uncharacterized protein
type: DnaReference
xref: PTHR11937:SF201
organism: Monodelphis domestica

uniprot Q9VW71 968
type: UnificationXref
id: Q9VW71
db: uniprot

G protein subunit alpha q
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot K6ZCJ5 1450
organism: Pan troglodytes

Frizzled class receptor 5
type: ProteinReference
xref: uniprot E2QVP7 77
xref: PTHR11309:SF136
organism: Canis lupus familiaris

uniprot Q93098 1272
type: UnificationXref
id: Q93098
db: uniprot

uniprot O70421 115
type: UnificationXref
id: O70421
db: uniprot

uniprot K6ZCJ5 1450
type: UnificationXref
id: K6ZCJ5
db: uniprot

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF201
xref: uniprot F7D539 2058
organism: Monodelphis domestica

Actin alpha cardiac muscle 1b
type: DnaReference
xref: PTHR11937:SF184
organism: Danio rerio

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1PPK6 1045
organism: Canis lupus familiaris

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 2042

uniprot O70283 1217
type: UnificationXref
id: O70283
db: uniprot

Casein kinase 1-like protein 13
type: ProteinReference
xref: uniprot Q5XF24 1836
xref: PTHR11909:SF355
organism: Arabidopsis thaliana

Myosin, heavy polypeptide 1.1, skeletal muscle
type: DnaReference
xref: PTHR45615:SF44
organism: Danio rerio

uniprot P97588 1549
type: UnificationXref
id: P97588
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10799:SF76
xref: uniprot F7GWD7 319
organism: Macaca mulatta

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: serine33 Beta Catenin s270 a146 rs3
feature: Serine45 Beta Catenin s270 a146 rs1
feature: Beta Catenin s270 a146 rs5
feature: Threonine41 Beta Catenin s270 a146 rs4
feature: Serine35 Beta Catenin s270 a146 rs2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24028:SF263
xref: uniprot F6WZD8 736
organism: Macaca mulatta

uniprot Q9C5P6 1369
type: UnificationXref
id: Q9C5P6
db: uniprot

Casein Kinase 1
type: Protein
entity reference: Casein Kinase 1
feature: ACTIVE 50
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7CFQ6 1540
type: UnificationXref
id: F7CFQ6
db: uniprot

uniprot Q65CL1 2036
type: UnificationXref
id: Q65CL1
db: uniprot

uniprot B8JIQ1 1012
type: UnificationXref
id: B8JIQ1
db: uniprot

PTHR12533:SF11
type: RelationshipXref
id: PTHR12533:SF11
db: PANTHER Family
relationship type: By Homology

uniprot O35468 1216
type: UnificationXref
id: O35468
db: uniprot

uniprot Q80W83 594
type: UnificationXref
id: Q80W83
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot A2VDU3 1035
xref: PTHR46716:SF1
organism: Bos taurus

TCF s89 sa59 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q0VC01 2080
type: UnificationXref
id: Q0VC01
db: uniprot

uniprot Q61090 128
type: UnificationXref
id: Q61090
db: uniprot

Transducin-like enhancer protein 1
type: ProteinReference
xref: uniprot Q62440 492
xref: PTHR10814:SF29
organism: Mus musculus

Beta-arrestin-1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot Q8BWG8 1589
organism: Mus musculus

uniprot F7F0X3 315
type: UnificationXref
id: F7F0X3
db: uniprot

Transducin-like enhancer protein 4
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot Q62441 493
organism: Mus musculus

AGAP006256-PA
type: ProteinReference
xref: uniprot Q7PPB2 876
xref: PTHR24026:SF106
organism: Anopheles gambiae

Cadherin 20
type: ProteinReference
xref: PTHR24027:SF84
xref: uniprot F7BBY2 746
organism: Xenopus tropicalis

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

Transcription factor 7-like 1
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot Q9Z1J1 520
organism: Mus musculus

uniprot H2XJE9 1426
type: UnificationXref
id: H2XJE9
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot E1BWA3 1652
organism: 9031

Protein Wnt-11b-1
type: ProteinReference
xref: uniprot Q66II0 1266
xref: PTHR12027:SF34
organism: Xenopus tropicalis

uniprot P09803 812
type: UnificationXref
id: P09803
db: uniprot

uniprot F1P8X5 712
type: UnificationXref
id: F1P8X5
db: uniprot

uniprot F1NTD3 1043
type: UnificationXref
id: F1NTD3
db: uniprot

uniprot B2RWS6 1400
type: UnificationXref
id: B2RWS6
db: uniprot

uniprot Q60838 1395
type: UnificationXref
id: Q60838
db: uniprot

Lymphoid enhancer-binding factor 1
type: ProteinReference
xref: uniprot Q9UJU2 517
xref: PTHR10373:SF11
organism: Homo sapiens

Secreted frizzled-related protein 1
type: ProteinReference
xref: PTHR11309:SF87
xref: uniprot F6SGW3 230
organism: Macaca mulatta

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot F6YA42 1536
organism: 9258

Protein CBR-ARR-1
type: ProteinReference
xref: uniprot A8X5S0 1563
xref: PTHR11792:SF17
organism: Caenorhabditis briggsae

uniprot Q92048 1269
type: UnificationXref
id: Q92048
db: uniprot

Uncharacterized ATP-dependent helicase YqhH
type: ProteinReference
xref: uniprot P54509 366
xref: PTHR10799:SF971
organism: 224308

Uncharacterized protein
type: ProteinReference
xref: PTHR13844:SF2
xref: uniprot A0A1D5QEA3 248
organism: Macaca mulatta

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot G7N677 178
xref: PTHR24270:SF12
organism: Macaca mulatta

Protocadherin alpha-2
type: ProteinReference
xref: uniprot Q5DRF0 866
xref: PTHR24028:SF60
organism: Pan troglodytes

serine33 Beta Catenin s135 sa120 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s135 sa120 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

Transducin-like enhancer of split 2
type: ProteinReference
xref: PTHR10814:SF4
xref: uniprot F6TID6 468
organism: Xenopus tropicalis

uniprot P61092 210
type: UnificationXref
id: P61092
db: uniprot

uniprot E2QX86 279
type: UnificationXref
id: E2QX86
db: uniprot

FZD10 isoform 2
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot H2Q772 105
organism: Pan troglodytes

Cadherin 11, type 2, OB-cadherin (Osteoblast)
type: ProteinReference
xref: PTHR24027:SF85
xref: uniprot A2VDQ6 659
organism: Bos taurus

uniprot Q7QDV6 133
type: UnificationXref
id: Q7QDV6
db: uniprot

uniprot Q9FH09 2101
type: UnificationXref
id: Q9FH09
db: uniprot

uniprot F1Q0S3 1909
type: UnificationXref
id: F1Q0S3
db: uniprot

Frizzled class receptor 5
type: ProteinReference
xref: uniprot B3DIG4 75
xref: PTHR11309:SF139
organism: Danio rerio

uniprot K7BA21 1107
type: UnificationXref
id: K7BA21
db: uniprot

uniprot Q8S3N1 220
type: UnificationXref
id: Q8S3N1
db: uniprot

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot Q5FVA4 213
xref: PTHR45877:SF1
organism: Xenopus tropicalis

Smad4
type: Protein
entity reference: Smad4
feature: COMPLEX PARTICIPANT BINDING FEATURE s109 sa74 2172
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Transducin-like enhancer of split 4
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot F6TIF1 469
organism: Xenopus tropicalis

uniprot Q9Y5F8 984
type: UnificationXref
id: Q9Y5F8
db: uniprot

uniprot F7FVG8 1525
type: UnificationXref
id: F7FVG8
db: uniprot

uniprot A0A1D5NXQ4 1785
type: UnificationXref
id: A0A1D5NXQ4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 1955
xref: PTHR13809:SF9
organism: Canis lupus familiaris

uniprot Q63269 46
type: UnificationXref
id: Q63269
db: uniprot

uniprot P97291 840
type: UnificationXref
id: P97291
db: uniprot

Serine45 Beta Catenin s92 sa62 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s92 sa62 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

uniprot F1MCE7 1040
type: UnificationXref
id: F1MCE7
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot A0A0G2K6Q8 1125
xref: PTHR12027:SF76
organism: Rattus norvegicus

Dishevelled s150 sa135 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dishevelled
stoichiometric coefficient: 1.0

uniprot Q66HZ0 1359
type: UnificationXref
id: Q66HZ0
db: uniprot

uniprot Q24292 849
type: UnificationXref
id: Q24292
db: uniprot

Protocadherin 8, gene 2
type: ProteinReference
xref: uniprot F6VDD4 729
xref: PTHR24028:SF46
organism: Xenopus tropicalis

uniprot Q9RUX1 442
type: UnificationXref
id: Q9RUX1
db: uniprot

uniprot Q9JMF3 1985
type: UnificationXref
id: Q9JMF3
db: uniprot

Catenin, beta 2
type: ProteinReference
xref: uniprot E7FC99 186
organism: Danio rerio

uniprot P68399 1761
type: UnificationXref
id: P68399
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot F7FXA9 1613
organism: Macaca mulatta

uniprot O18178 565
type: UnificationXref
id: O18178
db: uniprot

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F7DVK7 205
organism: Monodelphis domestica

ncbitaxon 69014 1998
type: UnificationXref
id: 69014
db: ncbitaxon

uniprot Q9HCL0 941
type: UnificationXref
id: Q9HCL0
db: uniprot

uniprot O35161 803
type: UnificationXref
id: O35161
db: uniprot

Diversin
type: Protein
entity reference: Diversin
feature: COMPLEX PARTICIPANT BINDING FEATURE s125 sa93 2200
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F1MP23 83
type: UnificationXref
id: F1MP23
db: uniprot

Wnt
type: Protein
entity reference: Wnt
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 1954
xref: PTHR13809:SF9
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GUW1 770
xref: PTHR24027:SF99
organism: Macaca mulatta

uniprot F7DRD8 756
type: UnificationXref
id: F7DRD8
db: uniprot

Chromatin-remodeling complex ATPase chain isw-1
type: ProteinReference
xref: uniprot P41877 360
xref: PTHR10799:SF967
organism: Caenorhabditis elegans

uniprot F1RD80 715
type: UnificationXref
id: F1RD80
db: uniprot

uniprot Q9FKD9 224
type: UnificationXref
id: Q9FKD9
db: uniprot

Frizzled-5
type: ProteinReference
xref: PTHR11309:SF136
xref: uniprot Q8CHL0 135
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR15185:SF5
xref: uniprot E2QWH2 1433
organism: Canis lupus familiaris

TRANSCRIPTION_LEFT__Wnt_Target_Genes-RIGHT__Wnt_Target_Genes-_re67
type: TemplateReaction
product: Wnt Target Genes
xref: TRANSCRIPTION
participant: Wnt Target Genes s195 a449
participant: Wnt Target Genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PTHR23257:SF700
type: RelationshipXref
id: PTHR23257:SF700
db: PANTHER Family
relationship type: By Homology

uniprot H2Q5Y6 1059
type: UnificationXref
id: H2Q5Y6
db: uniprot

uniprot Q08DP7 575
type: UnificationXref
id: Q08DP7
db: uniprot

PTHR10218:SF213
type: RelationshipXref
id: PTHR10218:SF213
db: PANTHER Family
relationship type: By Homology

PTHR45685:SF2
type: RelationshipXref
id: PTHR45685:SF2
db: PANTHER Family
relationship type: By Homology

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot Q9Z329 49
organism: Mus musculus

PTHR45685:SF1
type: RelationshipXref
id: PTHR45685:SF1
db: PANTHER Family
relationship type: By Homology

PTHR10218:SF217
type: RelationshipXref
id: PTHR10218:SF217
db: PANTHER Family
relationship type: By Homology

uniprot Q9JLS4 1892
type: UnificationXref
id: Q9JLS4
db: uniprot

Histone deacetylase
type: ProteinReference
xref: uniprot F7EW26 2059
xref: PTHR10625:SF203
organism: Macaca mulatta

NFATC3 isoform 2
type: ProteinReference
xref: uniprot K7DDW5 1481
xref: PTHR12533:SF6
organism: Pan troglodytes

F-box/WD repeat-containing protein 11
type: ProteinReference
xref: PTHR44129:SF4
xref: uniprot Q9UKB1 1529
organism: Homo sapiens

uniprot H2R709 1900
type: UnificationXref
id: H2R709
db: uniprot

uniprot Q9NYQ8 947
type: UnificationXref
id: Q9NYQ8
db: uniprot

uniprot Q9XSC1 246
type: UnificationXref
id: Q9XSC1
db: uniprot

S-antigen visual arrestin
type: ProteinReference
xref: PTHR11792:SF15
xref: uniprot H2QJM8 1569
organism: Pan troglodytes

uniprot Q7PYH7 1528
type: UnificationXref
id: Q7PYH7
db: uniprot

uniprot F1MGM1 81
type: UnificationXref
id: F1MGM1
db: uniprot

uniprot P63219 1974
type: UnificationXref
id: P63219
db: uniprot

uniprot Q9Y5F2 980
type: UnificationXref
id: Q9Y5F2
db: uniprot

PTHR11937:SF176
type: RelationshipXref
id: PTHR11937:SF176
db: PANTHER Family
relationship type: By Homology

YALI0D16863p
type: ProteinReference
xref: uniprot Q6C8U8 1770
xref: PTHR24054:SF0
organism: 284591

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Complex__Dishevelled_Beta_Arrestin__Frodo_-_ATP-RIGHT__ADP-_Complex__Dishevelled_Beta_Arrestin__Frodo_-_r104
controller: Complex (Frizzled/Wnt/ LRP5/6)

uniprot A0A3Q1N8M5 261
type: UnificationXref
id: A0A3Q1N8M5
db: uniprot

uniprot Q9NRZ9 437
type: UnificationXref
id: Q9NRZ9
db: uniprot

TCF
type: Protein
entity reference: TCF
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa232 2250
feature: TCF s57 sa232 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot B1WBR9 1143
type: UnificationXref
id: B1WBR9
db: uniprot

Galpha
type: ProteinReference
xref: P01451
standard name: G-protein, alpha subunit
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.G_alpha_
comment: ENTITY_REFERENCE_NOTES= Long Name: Galpha Synonym: G11,G15,Galpha11,Galpha15,Galphaq,Gq Accession: P01451
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Guanine nucleotide-binding protein subunit alpha-14
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: Q28FH0
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
member entity reference: Guanine nucleotide-binding protein G(q) subunit alpha
member entity reference: P30679
member entity reference: G protein subunit alpha 14
member entity reference: P30677
member entity reference: E1BA29
member entity reference: Q66JF0
member entity reference: P30678
member entity reference: G5EGU1
member entity reference: B8JLJ7
member entity reference: O88302
member entity reference: G protein alpha q subunit
member entity reference: Q5EAP4
member entity reference: G protein subunit alpha q

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot D3ZRW5 1154
organism: Rattus norvegicus

Beta Catenin s64 sa24 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

DISSOCIATION_LEFT__GTP-_Complex__G_Beta_Ggamma__Galpha_-RIGHT__GDP-_Galpha-_Complex__G_Beta_Ggamma_-_r74
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 2417
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 2416
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 2419
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 2418
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 2415
left: Complex (G_Beta/Ggamma/ Galpha)
left: GTP
interaction type: DISSOCIATION
right: Complex (G_Beta/Ggamma)
right: Galpha
right: GDP

Homeobox protein engrailed-1
type: DnaReference
xref: PTHR24341:SF4
organism: Homo sapiens

Homeobox protein engrailed-2
type: DnaReference
xref: PTHR24341:SF5
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot F7H6S1 1055
organism: Macaca mulatta

N-myc proto-oncogene protein
type: DnaReference
xref: PTHR45851:SF2
organism: Mus musculus

PTHR11937:SF168
type: RelationshipXref
id: PTHR11937:SF168
db: PANTHER Family
relationship type: By Homology

uniprot Q9UN72 959
type: UnificationXref
id: Q9UN72
db: uniprot

Cadherin 22
type: ProteinReference
xref: uniprot E2RJN9 685
xref: PTHR24027:SF311
organism: Canis lupus familiaris

uniprot A0A2I3RTC9 637
type: UnificationXref
id: A0A2I3RTC9
db: uniprot

uniprot F6VTH1 603
type: UnificationXref
id: F6VTH1
db: uniprot

uniprot Q91VD8 909
type: UnificationXref
id: Q91VD8
db: uniprot

Glycogen Synthase Kinase-3Beta
type: Protein
entity reference: Glycogen Synthase Kinase 3 Beta PROTEIN
feature: ACTIVE 50
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q6NV44 131
type: UnificationXref
id: Q6NV44
db: uniprot

Axin s72 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

uniprot O13682 340
type: UnificationXref
id: O13682
db: uniprot

uniprot Q96QU1 931
type: UnificationXref
id: Q96QU1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR44156:SF9
xref: uniprot F7FGS3 1524
organism: Monodelphis domestica

PTHR11937:SF150
type: RelationshipXref
id: PTHR11937:SF150
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot E9GCV0 1723
organism: 6669

ncbitaxon 13616 20
type: UnificationXref
id: 13616
db: ncbitaxon

PTHR10814:SF4
type: RelationshipXref
id: PTHR10814:SF4
db: PANTHER Family
relationship type: By Homology

Transducin-like enhancer of split 1
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot F6W7G5 470
organism: Xenopus tropicalis

PTHR10814:SF2
type: RelationshipXref
id: PTHR10814:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q7FRS8 1363
type: UnificationXref
id: Q7FRS8
db: uniprot

uniprot Q6GL20 130
type: UnificationXref
id: Q6GL20
db: uniprot

uniprot E1BIA5 674
type: UnificationXref
id: E1BIA5
db: uniprot

Ebi
type: Protein
entity reference: Ebi
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7H1V4 320
type: UnificationXref
id: F7H1V4
db: uniprot

Histone deacetylase 3
type: ProteinReference
xref: PTHR10625:SF201
xref: uniprot O15379 2067
organism: Homo sapiens

uniprot E2RMC0 15
type: UnificationXref
id: E2RMC0
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR45851:SF5
organism: Macaca mulatta

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7165 45
type: UnificationXref
id: 7165
db: ncbitaxon

Cadherin 7
type: ProteinReference
xref: PTHR24027:SF91
xref: uniprot E1BF53 673
organism: Bos taurus

uniprot Q5TQX0 44
type: UnificationXref
id: Q5TQX0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot G7NGI5 1424
xref: PTHR24055:SF380
organism: Macaca mulatta

uniprot F6R511 1727
type: UnificationXref
id: F6R511
db: uniprot

Cadherin-6
type: ProteinReference
xref: uniprot P97326 841
xref: PTHR24027:SF322
organism: Mus musculus

FI08417p
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot Q9VJC2 1872
organism: Drosophila melanogaster

Frizzled
type: Protein
entity reference: Frizzled
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa5 2318
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q7Q2V9 1587
type: UnificationXref
id: Q7Q2V9
db: uniprot

Beta Catenin s270 a146 rs5
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Wnt-RIGHT__Wnt-_re63
control type: INHIBITION
controller: sFRP

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62715 568
xref: PTHR45619:SF44
organism: Mus musculus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot P62716 569
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot P62714 567
organism: Homo sapiens

uniprot Q84JL3 216
type: UnificationXref
id: Q84JL3
db: uniprot

PTHR12656:SF11
type: RelationshipXref
id: PTHR12656:SF11
db: PANTHER Family
relationship type: By Homology

uniprot H2Q7M1 786
type: UnificationXref
id: H2Q7M1
db: uniprot

PTHR12656:SF12
type: RelationshipXref
id: PTHR12656:SF12
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF193
type: RelationshipXref
id: PTHR11937:SF193
db: PANTHER Family
relationship type: By Homology

Putative casein kinase I
type: ProteinReference
xref: PTHR11909:SF406
xref: uniprot O96999 1814
organism: Leishmania major

PTHR11937:SF192
type: RelationshipXref
id: PTHR11937:SF192
db: PANTHER Family
relationship type: By Homology

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot A0A0D1CEH3 2041
organism: Ustilago maydis

uniprot Q0G819 1346
type: UnificationXref
id: Q0G819
db: uniprot

uniprot Q8NER5 1086
type: UnificationXref
id: Q8NER5
db: uniprot

uniprot Q9BZA7 934
type: UnificationXref
id: Q9BZA7
db: uniprot

Histone deacetylase
type: ProteinReference
xref: uniprot Q38C74 2085
xref: PTHR10625:SF132
organism: Trypanosoma brucei

G1/S-specific cyclin-D1
type: DnaReference
xref: PTHR10177:SF67
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot Q09646 374
xref: PTHR13844:SF7
organism: Caenorhabditis elegans

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
type: ProteinReference
xref: uniprot Q91ZW3 424
xref: PTHR10799:SF879
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F7Z2 316
xref: PTHR46459:SF1
organism: Macaca mulatta

uniprot F6W1H1 733
type: UnificationXref
id: F6W1H1
db: uniprot

Casein Kinase 1
type: Protein
entity reference: Casein Kinase 1
feature: COMPLEX PARTICIPANT BINDING FEATURE s192 sa107 2132
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

AGAP004850-PA
type: ProteinReference
xref: uniprot Q7PPU8 877
xref: PTHR24026:SF51
organism: Anopheles gambiae

PTHR11937:SF184
type: RelationshipXref
id: PTHR11937:SF184
db: PANTHER Family
relationship type: By Homology

Serine45 Beta Catenin s88 sa58 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s88 sa58 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

uniprot A0A1D5QLW3 1470
type: UnificationXref
id: A0A1D5QLW3
db: uniprot

Cadherin 11
type: ProteinReference
xref: PTHR24027:SF85
xref: uniprot A0A2I3TJM5 644
organism: Pan troglodytes

Nuclear factor of activated T-cells, cytoplasmic 3
type: ProteinReference
xref: uniprot P97305 1483
xref: PTHR12533:SF6
organism: Mus musculus

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q08BT6 1699
xref: PTHR24356:SF159
organism: Xenopus tropicalis

uniprot F6Q8L1 1047
type: UnificationXref
id: F6Q8L1
db: uniprot

uniprot H2QQ88 1543
type: UnificationXref
id: H2QQ88
db: uniprot

uniprot E2RMD3 283
type: UnificationXref
id: E2RMD3
db: uniprot

Complex (Axin/PP2A)
type: Complex
component stoichiometry: PP2A s40 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: Axin s39 sa17 STOICHIOMETRY ID COMPLEX
component: PP2A s40 sa18
component: Axin
feature: COMPLEX BINDING FEATURE s120 a261 2325
feature: COMPLEX BINDING FEATURE s120 a261 2323
cellular location: plasma membrane

uniprot P09615 1223
type: UnificationXref
id: P09615
db: uniprot

uniprot P55283 827
type: UnificationXref
id: P55283
db: uniprot

uniprot A0A3Q1LJ38 653
type: UnificationXref
id: A0A3Q1LJ38
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P21278 1453
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot F7GI54 1947
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P21279 1454
organism: Mus musculus

Protein kinase C beta type
type: ProteinReference
xref: uniprot P68404 1692
xref: PTHR24356:SF158
organism: Mus musculus

uniprot F1N6L8 1171
type: UnificationXref
id: F1N6L8
db: uniprot

Cerberus
type: ProteinReference
xref: PTHR15273:SF4
xref: uniprot O95813 1292
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re69 2485
type: Stoichiometry
physical entity: Glycogen Synthase Kinase-3Beta
stoichiometric coefficient: 1.0

uniprot F6VTC2 306
type: UnificationXref
id: F6VTC2
db: uniprot

PARTICIPANT STOICHIOMETRY re69 2484
type: Stoichiometry
physical entity: Glycogen Synthase Kinase-3Beta
stoichiometric coefficient: 1.0

uniprot A0A3Q1M3K5 460
type: UnificationXref
id: A0A3Q1M3K5
db: uniprot

uniprot H2Q411 559
type: UnificationXref
id: H2Q411
db: uniprot

uniprot Q0IHM5 1079
type: UnificationXref
id: Q0IHM5
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot B0LK22 1142
xref: PTHR12027:SF82
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MLJ8 82
xref: PTHR11309:SF23
organism: Bos taurus

Kremen protein
type: ProteinReference
xref: uniprot E2R8I6 1896
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6VVA6 1100
xref: PTHR10336:SF12
organism: 9258

ncbitaxon 7719 1282
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot Q9H1J5 1275
type: UnificationXref
id: Q9H1J5
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F7DVL1 1664
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF96
xref: uniprot F7AAP1 744
organism: Monodelphis domestica

Helicase like transcription factor
type: ProteinReference
xref: uniprot F1MLM2 288
xref: PTHR45626:SF39
organism: Bos taurus

Protein Wnt
type: ProteinReference
xref: uniprot E1BEN9 1160
xref: PTHR12027:SF91
organism: Bos taurus

uniprot F1M702 697
type: UnificationXref
id: F1M702
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot Q0P594 576
organism: Bos taurus

Transcription activator BRG1
type: ProteinReference
xref: PTHR10799:SF76
xref: uniprot Q3TKT4 384
organism: Mus musculus

Actin alpha 1, skeletal muscle a
type: DnaReference
xref: PTHR11937:SF416
organism: Danio rerio

uniprot P55289 833
type: UnificationXref
id: P55289
db: uniprot

uniprot P22724 1226
type: UnificationXref
id: P22724
db: uniprot

Alpha-catenin related, isoform C
type: ProteinReference
xref: PTHR46342:SF1
xref: uniprot A0A0C4DHD7 2008
organism: Drosophila melanogaster

uniprot Q08122 490
type: UnificationXref
id: Q08122
db: uniprot

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot O95837 1452
organism: Homo sapiens

uniprot P57094 165
type: UnificationXref
id: P57094
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13809:SF52
xref: uniprot F7ASR8 1940
organism: Macaca mulatta

uniprot F7F7Z2 316
type: UnificationXref
id: F7F7Z2
db: uniprot

uniprot Q9WU82 197
type: UnificationXref
id: Q9WU82
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot A8Y4R8 530
xref: PTHR10257:SF3
organism: Caenorhabditis briggsae

Threonine41 Beta Catenin s100 sa70 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s100 sa70 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

TCF s106 sa73 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A3Q1MSZ9 1491
type: UnificationXref
id: A0A3Q1MSZ9
db: uniprot

uniprot Q5IS48 1394
type: UnificationXref
id: Q5IS48
db: uniprot

Dishevelled s2 a214 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.8230462015585855
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Protein Wnt
type: ProteinReference
xref: uniprot J9P5H0 1210
xref: PTHR12027:SF33
organism: Canis lupus familiaris

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot H2Q5Y6 1059
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E6Z1 759
xref: PTHR24026:SF37
organism: Macaca mulatta

Dishevelled
type: Protein
entity reference: Dishevelled
feature: Dishevelled s2 a214 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR11909:SF139
type: RelationshipXref
id: PTHR11909:SF139
db: PANTHER Family
relationship type: By Homology

uniprot Q5F3B5 1465
type: UnificationXref
id: Q5F3B5
db: uniprot

uniprot Q9U6V0 1281
type: UnificationXref
id: Q9U6V0
db: uniprot

uniprot Q9I9I2 1277
type: UnificationXref
id: Q9I9I2
db: uniprot

uniprot F6X0X1 549
type: UnificationXref
id: F6X0X1
db: uniprot

uniprot O15169 160
type: UnificationXref
id: O15169
db: uniprot

Cadherin-23
type: ProteinReference
xref: uniprot P58365 836
xref: PTHR24025:SF18
organism: Rattus norvegicus

uniprot F7E9U1 99
type: UnificationXref
id: F7E9U1
db: uniprot

uniprot Q18239 1392
type: UnificationXref
id: Q18239
db: uniprot

PTHR45877:SF2
type: RelationshipXref
id: PTHR45877:SF2
db: PANTHER Family
relationship type: By Homology

PTHR45877:SF1
type: RelationshipXref
id: PTHR45877:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F7CP86 553
type: UnificationXref
id: F7CP86
db: uniprot

Beta Arrestin s26 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Arrestin
stoichiometric coefficient: 1.0

AGAP003424-PA
type: ProteinReference
xref: uniprot Q7QDI9 2037
xref: PTHR18914:SF9
organism: Anopheles gambiae

uniprot G5EBH0 1102
type: UnificationXref
id: G5EBH0
db: uniprot

AGAP004166-PA
type: ProteinReference
xref: uniprot Q7PQL1 878
xref: PTHR24028:SF284
organism: Anopheles gambiae

uniprot Q90Z40 1982
type: UnificationXref
id: Q90Z40
db: uniprot

Cadherin 9
type: ProteinReference
xref: PTHR24027:SF99
xref: uniprot E2R971 683
organism: Canis lupus familiaris

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
type: ProteinReference
xref: uniprot E2QWV0 278
xref: PTHR10799:SF879
organism: Canis lupus familiaris

Serine45 Beta Catenin s100 sa70 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s100 sa70 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

PARTICIPANT STOICHIOMETRY r88 2510
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Glycogen Synthase Kinase-3Beta/Axin/ PP2A/Diversin/ Casein Kinase 1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r88 2511
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Axin/ PP2A/Diversin/ Casein Kinase 1/Beta-Catenin/ betaTrCP/Glycogen Synthase Kinase-3Beta)
stoichiometric coefficient: 1.0

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 369

Alpha-CaTuliN (Catenin/vinculin related)
type: ProteinReference
xref: PTHR46342:SF1
xref: uniprot H2L011 2023
organism: Caenorhabditis elegans

STATE_TRANSITION_LEFT__Ubiquitin-_Complex__Adenomatous_Polyposis_Coli_Axin__PP2A_Beta_Catenin__Siah_1_Ebi_-RIGHT__Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Siah_1_Ebi__Axin_PP2A_-_r96
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 2457
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 2459
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 2458
left: Complex Adenomatous Polyposis Coli Axin PP2A Beta Catenin Siah 1 Ebi s159 a368
left: Ubiquitin s268 a558
interaction type: STATE_TRANSITION
right: Complex Adenomatous Polyposis Coli Beta Catenin Siah 1 Ebi Axin PP2A s275 a579

C-terminal-binding protein 1
type: ProteinReference
xref: uniprot Q9DEG7 616
xref: PTHR46029:SF1
organism: Danio rerio

uniprot D4A510 273
type: UnificationXref
id: D4A510
db: uniprot

uniprot Q14738 579
type: UnificationXref
id: Q14738
db: uniprot

uniprot H9FVW1 1104
type: UnificationXref
id: H9FVW1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF425
xref: uniprot F7GVJ2 771
organism: Macaca mulatta

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
type: ProteinReference
xref: PTHR46232:SF1
xref: uniprot E2QX86 279
organism: Canis lupus familiaris

uniprot E2R7K2 1380
type: UnificationXref
id: E2R7K2
db: uniprot

uniprot A0A1D5RL09 525
type: UnificationXref
id: A0A1D5RL09
db: uniprot

uniprot Q7PM77 1267
type: UnificationXref
id: Q7PM77
db: uniprot

uniprot Q3MHM6 2033
type: UnificationXref
id: Q3MHM6
db: uniprot

NFATC4 isoform 9
type: ProteinReference
xref: uniprot A0A2I3TJ60 1472
xref: PTHR12533:SF11
organism: Pan troglodytes

uniprot P19107 1578
type: UnificationXref
id: P19107
db: uniprot

uniprot Q92925 426
type: UnificationXref
id: Q92925
db: uniprot

DISSOCIATION_LEFT__Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Axin_PP2A_-RIGHT__Complex__Adenomatous_Polyposis_Coli_Axin__PP2A_-_Beta_Catenin-_r99
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 2431
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 2433
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 2432
left: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Axin/PP2A)
interaction type: DISSOCIATION
right: Beta-Catenin
right: Complex Adenomatous Polyposis Coli Axin PP2A s164 a378

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot Q4QCE7 2086
type: UnificationXref
id: Q4QCE7
db: uniprot

PARTICIPANT STOICHIOMETRY r88 2509
type: Stoichiometry
physical entity: betaTrCP
stoichiometric coefficient: 1.0

Transducin (Beta)-like 1 X-linked (Predicted)
type: ProteinReference
xref: PTHR22846:SF52
xref: uniprot G3V6G5 1501
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__PP2A-_Axin-RIGHT__Complex__Axin_PP2A_-_r45
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 2407
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 2405
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 2406
left: PP2A
left: Axin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Axin/PP2A)

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot E9GTE8 1724
organism: 6669

DISSOCIATION_LEFT__Complex__betaTrCP_Beta_Catenin_-RIGHT__Beta_Catenin-_betaTrCP-_r92
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 2469
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 2468
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 2470
left: Complex (betaTrCP/Beta-Catenin)
interaction type: DISSOCIATION
right: Beta-Catenin
right: betaTrCP

Protocadherin 1
type: ProteinReference
xref: PTHR24028:SF247
xref: uniprot E2QX93 679
organism: Canis lupus familiaris

uniprot P74552 368
type: UnificationXref
id: P74552
db: uniprot

PARTICIPANT STOICHIOMETRY r85 2530
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot A0A0G2K9D6 247
type: UnificationXref
id: A0A0G2K9D6
db: uniprot

Casein kinase 1 gamma 2
type: ProteinReference
xref: uniprot E2QX25 1794
xref: PTHR11909:SF157
organism: Canis lupus familiaris

uniprot P20444 1683
type: UnificationXref
id: P20444
db: uniprot

Beta Catenin s111 sa83 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

Protocadherin-19
type: ProteinReference
xref: uniprot Q80TF3 888
xref: PTHR24028:SF40
organism: Mus musculus

betaTrCP s205 sa111 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: betaTrCP s205 sa111
stoichiometric coefficient: 1.0

uniprot F7HC75 1666
type: UnificationXref
id: F7HC75
db: uniprot

Actin, alpha, cardiac muscle 1
type: DnaReference
xref: PTHR11937:SF176
organism: Canis lupus familiaris

Cadherin 24
type: ProteinReference
xref: uniprot E2QX22 678
xref: PTHR24027:SF272
organism: Canis lupus familiaris

ncbitaxon 9598 6
type: UnificationXref
id: 9598
db: ncbitaxon

Serine/threonine-protein kinase NLK
type: ProteinReference
xref: uniprot E2QWQ2 1421
xref: PTHR24055:SF380
organism: Canis lupus familiaris

uniprot H9H985 1502
type: UnificationXref
id: H9H985
db: uniprot

Histone deacetylase
type: ProteinReference
xref: uniprot F6Z5R3 2057
xref: PTHR10625:SF188
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r85 2532
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Axin/PP2A/ Diversin/Casein Kinase 1)
stoichiometric coefficient: 1.0

uniprot P17343 1619
type: UnificationXref
id: P17343
db: uniprot

PARTICIPANT STOICHIOMETRY r85 2531
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot K6ZTZ3 339
type: UnificationXref
id: K6ZTZ3
db: uniprot

uniprot Q6DIC0 396
type: UnificationXref
id: Q6DIC0
db: uniprot

uniprot A0A2R8QFQ6 1515
type: UnificationXref
id: A0A2R8QFQ6
db: uniprot

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Serine35 Beta Catenin s138 sa123 rs2
feature: Serine45 Beta Catenin s138 sa123 rs1
feature: Beta Catenin s138 sa123 rs5
feature: Threonine41 Beta Catenin s138 sa123 rs4
feature: serine33 Beta Catenin s138 sa123 rs3
feature: COMPLEX PARTICIPANT BINDING FEATURE s138 sa123 2340
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Transducin like enhancer of split 3
type: ProteinReference
xref: PTHR10814:SF24
xref: uniprot F1ML22 464
organism: Bos taurus

uniprot Q5DWV2 868
type: UnificationXref
id: Q5DWV2
db: uniprot

ncbitaxon 243232 1997
type: UnificationXref
id: 243232
db: ncbitaxon

uniprot O84714 350
type: UnificationXref
id: O84714
db: uniprot

uniprot P29067 1581
type: UnificationXref
id: P29067
db: uniprot

uniprot Q7PPU8 877
type: UnificationXref
id: Q7PPU8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6S0B5 720
xref: PTHR24028:SF9
organism: Monodelphis domestica

uniprot P55288 832
type: UnificationXref
id: P55288
db: uniprot

uniprot F6VFP8 732
type: UnificationXref
id: F6VFP8
db: uniprot

uniprot F1N9Y3 465
type: UnificationXref
id: F1N9Y3
db: uniprot

uniprot Q8VHP6 901
type: UnificationXref
id: Q8VHP6
db: uniprot

uniprot F1PL90 1095
type: UnificationXref
id: F1PL90
db: uniprot

Casein Kinase 1
type: Protein
entity reference: Casein Kinase 1
feature: COMPLEX PARTICIPANT BINDING FEATURE s126 sa94 2202
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F4J9M5 295
type: UnificationXref
id: F4J9M5
db: uniprot

PTHR11909:SF157
type: RelationshipXref
id: PTHR11909:SF157
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF151
type: RelationshipXref
id: PTHR11909:SF151
db: PANTHER Family
relationship type: By Homology

uniprot Q5ZK40 392
type: UnificationXref
id: Q5ZK40
db: uniprot

PTHR11909:SF155
type: RelationshipXref
id: PTHR11909:SF155
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF156
type: RelationshipXref
id: PTHR11909:SF156
db: PANTHER Family
relationship type: By Homology

uniprot H2R360 330
type: UnificationXref
id: H2R360
db: uniprot

uniprot Q5DRB3 853
type: UnificationXref
id: Q5DRB3
db: uniprot

Threonine41 Beta Catenin s128 sa114 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s128 sa114 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

Protein Wnt
type: ProteinReference
xref: uniprot F7E738 1188
xref: PTHR12027:SF86
organism: Macaca mulatta

uniprot P51140 1390
type: UnificationXref
id: P51140
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MSZ9 1491
xref: PTHR22846:SF40
organism: Bos taurus

uniprot A0A1D5QB83 2009
type: UnificationXref
id: A0A1D5QB83
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MSZ4 1375
xref: PTHR10878:SF8
organism: Bos taurus

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
type: ProteinReference
xref: PTHR10799:SF541
xref: uniprot J9P5P2 338
organism: Canis lupus familiaris

uniprot P62715 568
type: UnificationXref
id: P62715
db: uniprot

Frizzled class receptor 2
type: ProteinReference
xref: uniprot F1QBI2 85
xref: PTHR11309:SF34
organism: Danio rerio

uniprot Q5DRD2 859
type: UnificationXref
id: Q5DRD2
db: uniprot

uniprot P55291 835
type: UnificationXref
id: P55291
db: uniprot

SMARCC2 isoform 2
type: ProteinReference
xref: PTHR12802:SF105
xref: uniprot A0A2I3T0A7 255
organism: Pan troglodytes

TCF s89 sa59 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCF s89 sa59
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F1Q0G6 1496
xref: PTHR22846:SF52
organism: Canis lupus familiaris

betaTrCP
type: Protein
entity reference: beta TrCP PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s200 sa109 2136
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q4QC21 1353
type: UnificationXref
id: Q4QC21
db: uniprot

Cadherin EGF LAG seven-pass G-type receptor 3
type: ProteinReference
xref: PTHR24026:SF38
xref: uniprot Q91ZI0 927
organism: Mus musculus

C-terminal binding protein 2
type: ProteinReference
xref: PTHR46029:SF3
xref: uniprot A0A3Q2U0V6 601
organism: 9031

Beta Catenin s69 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

uniprot Q06986 212
type: UnificationXref
id: Q06986
db: uniprot

FZD5 isoform 1
type: ProteinReference
xref: uniprot H2QJA9 107
xref: PTHR11309:SF136
organism: Pan troglodytes

uniprot G3V8N1 779
type: UnificationXref
id: G3V8N1
db: uniprot

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 5
type: ProteinReference
xref: uniprot F6Y042 309
xref: PTHR10799:SF879
organism: Xenopus tropicalis

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 1573

uniprot Q9Y5G7 990
type: UnificationXref
id: Q9Y5G7
db: uniprot

Beta Catenin s206 sa112 rs5
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

uniprot A0A0G2K5L1 620
type: UnificationXref
id: A0A0G2K5L1
db: uniprot

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Halobacterium salinarum

PARTICIPANT STOICHIOMETRY r67 2438
type: Stoichiometry
physical entity: Complex (Beta-Catenin/TCF/ Smad4/Bcl9/ Pygo/SWI/ SNF)
stoichiometric coefficient: 1.0

Frizzled
type: ProteinReference
xref: uniprot P18537 118
xref: PTHR11309:SF47
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r67 2439
type: Stoichiometry
physical entity: Complex (Bcl9/Pygo/ Beta-Catenin/SWI/ SNF/CBP/ TCF/Smad4)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 2437
type: Stoichiometry
physical entity: CBP
stoichiometric coefficient: 1.0

TCF s57 sa232 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 1981
xref: PTHR13809:SF5
organism: Mus musculus

PPARD protein
type: DnaReference
xref: PTHR24082:SF15
organism: Bos taurus

uniprot F6TFY2 1932
type: UnificationXref
id: F6TFY2
db: uniprot

uniprot Q9UI47 2040
type: UnificationXref
id: Q9UI47
db: uniprot

uniprot P40229 1753
type: UnificationXref
id: P40229
db: uniprot

Siah 1 s20 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Siah 1 s20 sa10
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10687 1109
xref: PTHR10336:SF12
organism: Rattus norvegicus

ncbitaxon 5664 1354
type: UnificationXref
id: 5664
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot Q90Z40 1982
organism: Danio rerio

Protein Wnt
type: ProteinReference
xref: uniprot A0A1D5RE70 1130
xref: PTHR12027:SF76
organism: Macaca mulatta

uniprot E1BEN9 1160
type: UnificationXref
id: E1BEN9
db: uniprot

uniprot P41221 1239
type: UnificationXref
id: P41221
db: uniprot

PTHR45619:SF42
type: RelationshipXref
id: PTHR45619:SF42
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r85 2529
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Axin/ Diversin/Beta-Catenin/ PP2A)
stoichiometric coefficient: 1.0

PTHR45619:SF44
type: RelationshipXref
id: PTHR45619:SF44
db: PANTHER Family
relationship type: By Homology

uniprot F7HTZ1 607
type: UnificationXref
id: F7HTZ1
db: uniprot

AGAP010700-PA
type: ProteinReference
xref: uniprot Q7QE14 409
xref: PTHR10799:SF967
organism: Anopheles gambiae

uniprot Q9Y5H4 996
type: UnificationXref
id: Q9Y5H4
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot H9EU39 1670
organism: Macaca mulatta

uniprot P52287 1624
type: UnificationXref
id: P52287
db: uniprot

TCF7L1 isoform 2
type: DnaReference
xref: PTHR10373:SF25
organism: Pan troglodytes

Shaggy-related protein kinase beta
type: ProteinReference
xref: uniprot O23145 1017
organism: Arabidopsis thaliana

TCF
type: Protein
entity reference: TCF
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa46 2246
feature: TCF s57 sa46 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE TRANSITION LEFT Complex Adenomatous Polyposis Coli Axin Diversin Beta Catenin PP2A - ATP-RIGHT ADP- Complex Adenomatous Polyposis Coli Beta Catenin Axin PP2A Diversin Casein Kinase 1 - r85
controller: Casein Kinase 1

uniprot P63099 1338
type: UnificationXref
id: P63099
db: uniprot

uniprot P29066 1580
type: UnificationXref
id: P29066
db: uniprot

Secreted frizzled-related protein 1
type: ProteinReference
xref: PTHR11309:SF87
xref: uniprot Q9DEQ4 243
organism: 9031

Protein CBR-KIN-3
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot A8XFP5 1713
organism: Caenorhabditis briggsae

uniprot J9P5P2 338
type: UnificationXref
id: J9P5P2
db: uniprot

PTHR24028:SF9
type: RelationshipXref
id: PTHR24028:SF9
db: PANTHER Family
relationship type: By Homology

PTHR24028:SF1
type: RelationshipXref
id: PTHR24028:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q61011 1636
type: UnificationXref
id: Q61011
db: uniprot

uniprot E9Q5G2 690
type: UnificationXref
id: E9Q5G2
db: uniprot

uniprot G5EDV1 104
type: UnificationXref
id: G5EDV1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M024 656
xref: PTHR24028:SF247
organism: Bos taurus

Candida albicans
type: BioSource
xref: ncbitaxon 237561 1768

uniprot Q75LU8 1362
type: UnificationXref
id: Q75LU8
db: uniprot

PTHR24028:SF0
type: RelationshipXref
id: PTHR24028:SF0
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot A0A1D5Q4D0 1089
organism: Macaca mulatta

uniprot Q9HAV0 1643
type: UnificationXref
id: Q9HAV0
db: uniprot

C-terminal-binding protein 1
type: ProteinReference
xref: PTHR46029:SF2
xref: uniprot Q9Z2F5 618
organism: Rattus norvegicus

Protocadherin-8
type: ProteinReference
xref: PTHR24028:SF46
xref: uniprot Q7TSK3 887
organism: Mus musculus

PTHR45619:SF12
type: RelationshipXref
id: PTHR45619:SF12
db: PANTHER Family
relationship type: By Homology

uniprot A7MB46 661
type: UnificationXref
id: A7MB46
db: uniprot

uniprot Q0VCQ1 612
type: UnificationXref
id: Q0VCQ1
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot F1NLM6 542
organism: 9031

uniprot A4D7S0 1136
type: UnificationXref
id: A4D7S0
db: uniprot

uniprot Q80TF3 888
type: UnificationXref
id: Q80TF3
db: uniprot

uniprot F6XWE8 1938
type: UnificationXref
id: F6XWE8
db: uniprot

uniprot Q7YSW8 1366
type: UnificationXref
id: Q7YSW8
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot H2QJF8 1204
organism: Pan troglodytes

Serine/threonine kinase NLK
type: ProteinReference
xref: PTHR24055:SF484
xref: uniprot Q9U9Y8 1429
organism: Caenorhabditis elegans

uniprot A0A1D5Q2V8 627
type: UnificationXref
id: A0A1D5Q2V8
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot A0A3Q1MSP9 1647
organism: Bos taurus

Dishevelled
type: Protein
entity reference: Dishevelled
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa16 2106
feature: Dishevelled s38 sa16 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

CSNK1D isoform 8
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot A0A2I3RNK5 1788
organism: Pan troglodytes

PTHR12176:SF64
type: RelationshipXref
id: PTHR12176:SF64
db: PANTHER Family
relationship type: By Homology

uniprot Q10428 577
type: UnificationXref
id: Q10428
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot B3S653 532
organism: 10228

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 1623
xref: PTHR19850:SF25
organism: Dictyostelium discoideum

uniprot Q13547 2082
type: UnificationXref
id: Q13547
db: uniprot

uniprot F7FIC8 1899
type: UnificationXref
id: F7FIC8
db: uniprot

uniprot Q9UN74 961
type: UnificationXref
id: Q9UN74
db: uniprot

uniprot P67868 1757
type: UnificationXref
id: P67868
db: uniprot

PTHR46029:SF2
type: RelationshipXref
id: PTHR46029:SF2
db: PANTHER Family
relationship type: By Homology

SWI/SNF
type: Protein
entity reference: SWI/SNF
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot K7CC23 1884
type: UnificationXref
id: K7CC23
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Kremen-_Dickkopf-RIGHT__Complex__Dickkopf_Kremen_-_r6
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 2390
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 2389
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 2388
left: Dickkopf
left: Kremen
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Dickkopf/Kremen)

PTHR46029:SF3
type: RelationshipXref
id: PTHR46029:SF3
db: PANTHER Family
relationship type: By Homology

PTHR46029:SF1
type: RelationshipXref
id: PTHR46029:SF1
db: PANTHER Family
relationship type: By Homology

Adenylosuccinate synthetase isozyme 2
type: DnaReference
xref: PTHR11846:SF13
organism: Macaca mulatta

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
type: ProteinReference
xref: uniprot Q0II51 375
xref: PTHR13844:SF5
organism: Bos taurus

PTHR46029:SF7
type: RelationshipXref
id: PTHR46029:SF7
db: PANTHER Family
relationship type: By Homology

uniprot Q9NZC9 438
type: UnificationXref
id: Q9NZC9
db: uniprot

uniprot K7CVS9 1734
type: UnificationXref
id: K7CVS9
db: uniprot

Lymphoid enhancer binding factor 1
type: ProteinReference
xref: uniprot F1Q334 505
xref: PTHR10373:SF11
organism: Canis lupus familiaris

uniprot F7C1G3 1803
type: UnificationXref
id: F7C1G3
db: uniprot

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: serine33 Beta Catenin s36 a37 rs3
feature: Threonine41 Beta Catenin s36 a37 rs4
feature: Beta Catenin s36 a37 rs5
feature: ACTIVE 50
feature: Serine35 Beta Catenin s36 a37 rs2
feature: Serine45 Beta Catenin s36 a37 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6RE45 1423
type: UnificationXref
id: F6RE45
db: uniprot

uniprot P28470 1328
type: UnificationXref
id: P28470
db: uniprot

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot P54367 1828
organism: Drosophila melanogaster

Axin 2
type: ProteinReference
xref: uniprot E2R9F8 155
xref: PTHR46102:SF1
organism: Canis lupus familiaris

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot Q15797 1551
organism: Homo sapiens

G protein subunit gamma 13
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot F7F4P1 1944
organism: 9258

Dishevelled segment polarity protein 2
type: ProteinReference
xref: uniprot F7BUW7 1384
xref: PTHR10878:SF8
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR44129:SF4
xref: uniprot A0A1D5NXE7 1512
organism: 9031

uniprot F7GI54 1947
type: UnificationXref
id: F7GI54
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot Q9P2W3 1987
organism: Homo sapiens

uniprot Q9NQ66 1120
type: UnificationXref
id: Q9NQ66
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR11267:SF106
organism: 7739

uniprot Q9Y5G3 987
type: UnificationXref
id: Q9Y5G3
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A8WR64 1649
xref: PTHR24356:SF347
organism: Caenorhabditis briggsae

Protocadherin 1
type: ProteinReference
xref: uniprot F7ET26 761
xref: PTHR24028:SF247
organism: Monodelphis domestica

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Dishevelled-RIGHT__Dishevelled-_re64
control type: INHIBITION
controller: Dapper

uniprot P70408 838
type: UnificationXref
id: P70408
db: uniprot

uniprot H2R2C6 109
type: UnificationXref
id: H2R2C6
db: uniprot

uniprot Q9BQ87 1507
type: UnificationXref
id: Q9BQ87
db: uniprot

Protein kinase C-like 3
type: ProteinReference
xref: uniprot Q19266 1700
xref: PTHR24356:SF303
organism: Caenorhabditis elegans

uniprot P38615 1019
type: UnificationXref
id: P38615
db: uniprot

uniprot Q5U302 2034
type: UnificationXref
id: Q5U302
db: uniprot

uniprot H2RCY2 1062
type: UnificationXref
id: H2RCY2
db: uniprot

Protein Wnt-7b
type: ProteinReference
xref: PTHR12027:SF73
xref: uniprot Q3L254 1262
organism: 9031

uniprot H2QRU2 798
type: UnificationXref
id: H2QRU2
db: uniprot

uniprot F6YIM6 2056
type: UnificationXref
id: F6YIM6
db: uniprot

Protocadherin-15
type: ProteinReference
xref: PTHR24028:SF11
xref: uniprot Q96QU1 931
organism: Homo sapiens

uniprot H2Q772 105
type: UnificationXref
id: H2Q772
db: uniprot

uniprot K7D8P4 1735
type: UnificationXref
id: K7D8P4
db: uniprot

uniprot A0A3Q1M504 600
type: UnificationXref
id: A0A3Q1M504
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot E1BDG5 1159
xref: PTHR12027:SF33
organism: Bos taurus

Frizzled class receptor 4
type: ProteinReference
xref: uniprot E2RIL8 80
xref: PTHR11309:SF23
organism: Canis lupus familiaris

uniprot Q9PWH2 145
type: UnificationXref
id: Q9PWH2
db: uniprot

Beta-arrestin arr-1
type: ProteinReference
xref: uniprot P51485 1586
xref: PTHR11792:SF17
organism: Caenorhabditis elegans

uniprot Q6P9Z1 398
type: UnificationXref
id: Q6P9Z1
db: uniprot

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: 100226

Axin-1
type: DnaReference
xref: PTHR46102:SF3
organism: Mus musculus

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot Q08209 1345
organism: Homo sapiens

Cadherin-7
type: ProteinReference
xref: PTHR24027:SF91
xref: uniprot Q9ULB5 954
organism: Homo sapiens

Cadherin-9
type: ProteinReference
xref: PTHR24027:SF99
xref: uniprot Q9ULB4 953
organism: Homo sapiens

uniprot D4AAV5 55
type: UnificationXref
id: D4AAV5
db: uniprot

uniprot Q9LID3 1866
type: UnificationXref
id: Q9LID3
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F6SF10 1174
xref: PTHR12027:SF75
organism: Monodelphis domestica

uniprot Q95117 1891
type: UnificationXref
id: Q95117
db: uniprot

Sizzled
type: ProteinReference
xref: uniprot F6ZIJ4 1881
xref: PTHR11309:SF11
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UDY7 262
xref: PTHR45685:SF2
organism: 9031

ncbitaxon 224308 367
type: UnificationXref
id: 224308
db: ncbitaxon

Cadherin 3
type: ProteinReference
xref: PTHR24027:SF267
xref: uniprot F1LMI3 692
organism: Rattus norvegicus

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF203
xref: uniprot F1PR63 2052
organism: Canis lupus familiaris

Dishevelled
type: Protein
entity reference: Dishevelled
feature: Dishevelled s23 sa12 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa12 2328
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Bcl9 s95 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Bcl9 s95 sa65
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot A0A1D5NXB2 1374
organism: 9031

Cadherin EGF LAG seven-pass G-type receptor 1
type: ProteinReference
xref: uniprot O35161 803
xref: PTHR24026:SF36
organism: Mus musculus

uniprot Q9YGX6 1287
type: UnificationXref
id: Q9YGX6
db: uniprot

Helicase like transcription factor
type: ProteinReference
xref: uniprot E2R9I5 280
xref: PTHR45626:SF39
organism: Canis lupus familiaris

uniprot Q13467 121
type: UnificationXref
id: Q13467
db: uniprot

Cadherin-24
type: ProteinReference
xref: PTHR24027:SF272
xref: uniprot Q6PFX6 873
organism: Mus musculus

Beta-transducin repeat-containing E3 ubiquitin protein ligase
type: ProteinReference
xref: PTHR14604:SF4
xref: uniprot F1LMH8 1519
organism: Rattus norvegicus

uniprot Q09646 374
type: UnificationXref
id: Q09646
db: uniprot

Threonine41 Beta Catenin s135 sa120 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s135 sa120 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

Protein kinase C
type: ProteinReference
xref: uniprot F6RA79 1659
xref: PTHR24356:SF193
organism: Monodelphis domestica

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot A0A1D5QTT6 1532
xref: PTHR13703:SF45
organism: Macaca mulatta

uniprot B0LK22 1142
type: UnificationXref
id: B0LK22
db: uniprot

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 1606
xref: PTHR19850:SF29
organism: 9258

uniprot Q6DFM1 395
type: UnificationXref
id: Q6DFM1
db: uniprot

uniprot F7HN04 775
type: UnificationXref
id: F7HN04
db: uniprot

uniprot Q61301 2035
type: UnificationXref
id: Q61301
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 1924
xref: PTHR13809:SF6
organism: Canis lupus familiaris

uniprot F6U7A6 547
type: UnificationXref
id: F6U7A6
db: uniprot

TLE3 isoform 10
type: ProteinReference
xref: uniprot H2Q9Q1 474
xref: PTHR10814:SF24
organism: Pan troglodytes

uniprot Q9P7S3 439
type: UnificationXref
id: Q9P7S3
db: uniprot

Chromatin-remodeling ATPase INO80
type: ProteinReference
xref: uniprot Q9ULG1 444
xref: PTHR45685:SF2
organism: Homo sapiens

uniprot A0A2I3RVR8 169
type: UnificationXref
id: A0A2I3RVR8
db: uniprot

uniprot Q4KLI0 385
type: UnificationXref
id: Q4KLI0
db: uniprot

PARTICIPANT STOICHIOMETRY r54 2523
type: Stoichiometry
physical entity: Complex Adenomatous Polyposis Coli Axin Beta Catenin PP2A s123 a275
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 2522
type: Stoichiometry
physical entity: Complex (Ebi/Siah-1)
stoichiometric coefficient: 1.0

AGAP002310-PA
type: ProteinReference
xref: uniprot Q7PR41 879
xref: PTHR24026:SF93
organism: Anopheles gambiae

uniprot F1LR98 693
type: UnificationXref
id: F1LR98
db: uniprot

PARTICIPANT STOICHIOMETRY r54 2524
type: Stoichiometry
physical entity: Complex Adenomatous Polyposis Coli Axin PP2A Beta Catenin Siah 1 Ebi s159 a368
stoichiometric coefficient: 1.0

uniprot F6ZKL2 1101
type: UnificationXref
id: F6ZKL2
db: uniprot

uniprot Q9EQD0 139
type: UnificationXref
id: Q9EQD0
db: uniprot

Cerberus
type: ProteinReference
xref: PTHR15273:SF4
xref: uniprot Q9PWB0 1293
organism: 9031

ncbitaxon 227321 1336
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot F6W7G5 470
type: UnificationXref
id: F6W7G5
db: uniprot

Frizzled class receptor 3
type: ProteinReference
xref: uniprot E2R9M9 78
xref: PTHR11309:SF22
organism: Canis lupus familiaris

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
type: ProteinReference
xref: PTHR13844:SF5
xref: uniprot Q6P9Z1 398
organism: Mus musculus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF84
xref: uniprot A0A3Q1M1A0 1134
organism: Bos taurus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot B7QGY5 534
organism: Ixodes scapularis

Protocadherin 12
type: ProteinReference
xref: PTHR24028:SF42
xref: uniprot F1MA46 700
organism: Rattus norvegicus

Frizzled class receptor 6
type: ProteinReference
xref: uniprot G3V6L1 103
xref: PTHR11309:SF75
organism: Rattus norvegicus

PTHR13715:SF87
type: RelationshipXref
id: PTHR13715:SF87
db: PANTHER Family
relationship type: By Homology

uniprot Q9UK08 1989
type: UnificationXref
id: Q9UK08
db: uniprot

Proto-oncogene Wnt-1
type: ProteinReference
xref: uniprot P04628 1221
xref: PTHR12027:SF91
organism: Homo sapiens

uniprot Q9Y5I3 1005
type: UnificationXref
id: Q9Y5I3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DX07 757
xref: PTHR24027:SF89
organism: Macaca mulatta

Arrestin-C
type: ProteinReference
xref: uniprot Q9N0H5 1593
xref: PTHR11792:SF19
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E905 1406
xref: PTHR13808:SF34
organism: Monodelphis domestica

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot Q0IHM5 1079
organism: Xenopus tropicalis

PTHR24027:SF106
type: RelationshipXref
id: PTHR24027:SF106
db: PANTHER Family
relationship type: By Homology

alpha-Catenin
type: ProteinReference
xref: P01471
standard name: alpha-catenin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: alpha-Catenin Synonym: Synonym not specified Accession: P01471
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC._alpha_-Catenin
member entity reference: Catenin alpha 1
member entity reference: F7FBX6
member entity reference: P26232
member entity reference: Uncharacterized protein
member entity reference: Catenin alpha-2
member entity reference: Catenin (Cadherin associated protein), alpha-like 1 (Predicted)
member entity reference: Alpha-catenin related, isoform C
member entity reference: Catenin alpha-1
member entity reference: O88327
member entity reference: Catenin alpha like 1
member entity reference: Catenin alpha 3
member entity reference: Catenin (Cadherin-associated protein), alpha
member entity reference: AGAP003424-PA
member entity reference: Alpha-catulin
member entity reference: Catenin alpha
member entity reference: F7ALE8
member entity reference: B7ZC77
member entity reference: Q9UI47
member entity reference: Alpha-catenin-like protein hmp-1
member entity reference: Catenin (Cadherin-associated protein), alpha 1, 102kDa
member entity reference: Catenin alpha-3
member entity reference: Alpha-CaTuliN (Catenin/vinculin related)
member entity reference: F6YFG3
member entity reference: P26231
member entity reference: Catenin (Cadherin associated protein), alpha 1

uniprot Q9VVG0 967
type: UnificationXref
id: Q9VVG0
db: uniprot

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 423

Pygo s91 sa61 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pygo s91 sa61
stoichiometric coefficient: 1.0

uniprot Q7PYV4 167
type: UnificationXref
id: Q7PYV4
db: uniprot

uniprot Q9JMK2 1865
type: UnificationXref
id: Q9JMK2
db: uniprot

Dishevelled segment polarity protein 2
type: ProteinReference
xref: uniprot D3ZB71 1377
xref: PTHR10878:SF8
organism: Rattus norvegicus

uniprot D3ZIE5 271
type: UnificationXref
id: D3ZIE5
db: uniprot

Serine/threonine-protein phosphatase 2B catalytic subunit
type: ProteinReference
xref: uniprot Q12705 1349
xref: PTHR45673:SF1
organism: 284812

PTHR23194:SF7
type: RelationshipXref
id: PTHR23194:SF7
db: PANTHER Family
relationship type: By Homology

Myc proto-oncogene protein
type: DnaReference
xref: PTHR45851:SF1
organism: Pan troglodytes

PTHR23194:SF3
type: RelationshipXref
id: PTHR23194:SF3
db: PANTHER Family
relationship type: By Homology

PTHR10799:SF76
type: RelationshipXref
id: PTHR10799:SF76
db: PANTHER Family
relationship type: By Homology

uniprot O70240 163
type: UnificationXref
id: O70240
db: uniprot

F-box-like/WD repeat-containing protein TBL1Y
type: ProteinReference
xref: PTHR22846:SF52
xref: uniprot Q9BQ87 1507
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR18914:SF23
xref: uniprot F6S406 2016
organism: Monodelphis domestica

uniprot F6XVG8 737
type: UnificationXref
id: F6XVG8
db: uniprot

uniprot A0A2I3RJ26 1296
type: UnificationXref
id: A0A2I3RJ26
db: uniprot

uniprot F7D539 2058
type: UnificationXref
id: F7D539
db: uniprot

Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Axin/PP2A/ Diversin/Casein Kinase 1)
type: Complex
component stoichiometry: Adenomatous Polyposis Coli s110 sa82 STOICHIOMETRY ID COMPLEX
component stoichiometry: Diversin s114 sa86 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Catenin s111 sa83 STOICHIOMETRY ID COMPLEX
component stoichiometry: PP2A s113 sa85 STOICHIOMETRY ID COMPLEX
component stoichiometry: Axin s112 sa84 STOICHIOMETRY ID COMPLEX
component stoichiometry: Casein Kinase 1 s115 sa87 STOICHIOMETRY ID COMPLEX
component: PP2A
component: Axin
component: Beta-Catenin
component: Adenomatous Polyposis Coli s110 sa82
component: Casein Kinase 1
component: Diversin s114 sa86
feature: COMPLEX BINDING FEATURE s245 a511 2383
feature: COMPLEX BINDING FEATURE s245 a511 2381
feature: COMPLEX BINDING FEATURE s245 a511 2373
feature: COMPLEX BINDING FEATURE s245 a511 2379
feature: COMPLEX BINDING FEATURE s245 a511 2377
feature: COMPLEX BINDING FEATURE s245 a511 2375
cellular location: plasma membrane

Protocadherin 9
type: ProteinReference
xref: uniprot F7BUJ8 749
xref: PTHR24028:SF248
organism: Xenopus tropicalis

uniprot F1LS01 694
type: UnificationXref
id: F1LS01
db: uniprot

Activin receptor type-1C
type: ProteinReference
xref: uniprot P70539 1074
organism: Rattus norvegicus

uniprot D3ZDI7 538
type: UnificationXref
id: D3ZDI7
db: uniprot

AGAP011360-PA (Fragment)
type: ProteinReference
xref: PTHR11792:SF17
xref: uniprot Q7Q2V9 1587
organism: Anopheles gambiae

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q9VYN5 1874
type: UnificationXref
id: Q9VYN5
db: uniprot

uniprot F4JY24 296
type: UnificationXref
id: F4JY24
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 1948
xref: PTHR13809:SF9
organism: Rattus norvegicus

uniprot P63217 1972
type: UnificationXref
id: P63217
db: uniprot

ARR3 isoform 1
type: ProteinReference
xref: uniprot H2QYR2 1570
xref: PTHR11792:SF19
organism: Pan troglodytes

uniprot P24257 1230
type: UnificationXref
id: P24257
db: uniprot

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
type: ProteinReference
xref: uniprot F7A4E9 310
xref: PTHR13844:SF2
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DX53 314
xref: PTHR12656:SF12
organism: Macaca mulatta

uniprot F6YS32 741
type: UnificationXref
id: F6YS32
db: uniprot

uniprot E7F1L8 1422
type: UnificationXref
id: E7F1L8
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot E2QXQ3 1162
xref: PTHR12027:SF7
organism: Canis lupus familiaris

Probable global transcription activator SNF2L1
type: ProteinReference
xref: PTHR10799:SF819
xref: uniprot Q6PGB8 401
organism: Mus musculus

PTHR10336:SF11
type: RelationshipXref
id: PTHR10336:SF11
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF12
type: RelationshipXref
id: PTHR10336:SF12
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF10
type: RelationshipXref
id: PTHR10336:SF10
db: PANTHER Family
relationship type: By Homology

uniprot Q99N43 1905
type: UnificationXref
id: Q99N43
db: uniprot

uniprot E1BKE7 14
type: UnificationXref
id: E1BKE7
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot A0A1D5NX70 1127
xref: PTHR12027:SF93
organism: 9031

Nemo-like Kinase
type: ProteinReference
xref: P01449
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Nemo-like Kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: Nemo-like Kinase Synonym: NLK Accession: P01449
member entity reference: Mitogen-activated protein kinase
member entity reference: Serine/threonine kinase NLK
member entity reference: Serine/threonine-protein kinase NLK
member entity reference: H2QCG7
member entity reference: O54949

uniprot A0A0G2K6Q8 1125
type: UnificationXref
id: A0A0G2K6Q8
db: uniprot

uniprot A0A2I3RLP7 1787
type: UnificationXref
id: A0A2I3RLP7
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 1622
xref: PTHR19850:SF30
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR45942:SF1
xref: uniprot F7C6H2 1317
organism: Monodelphis domestica

uniprot Q9FWQ5 1415
type: UnificationXref
id: Q9FWQ5
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot P51432 1113
xref: PTHR10336:SF11
organism: Mus musculus

uniprot O60353 114
type: UnificationXref
id: O60353
db: uniprot

uniprot Q92765 1890
type: UnificationXref
id: Q92765
db: uniprot

B-cell CLL/lymphoma 9 protein
type: ProteinReference
xref: PTHR15185:SF5
xref: uniprot O00512 1437
organism: Homo sapiens

uniprot P62874 1630
type: UnificationXref
id: P62874
db: uniprot

AGAP007739-PA
type: ProteinReference
xref: PTHR22846:SF2
xref: uniprot Q7Q371 1504
organism: Anopheles gambiae

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F7F580 1945
organism: Macaca mulatta

uniprot A0A2J8LQ70 1133
type: UnificationXref
id: A0A2J8LQ70
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6SEH5 1314
xref: PTHR45673:SF7
organism: Macaca mulatta

uniprot P97401 1885
type: UnificationXref
id: P97401
db: uniprot

uniprot A8KBH6 1648
type: UnificationXref
id: A8KBH6
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Glycogen_Synthase_Kinase_3Beta-RIGHT__Glycogen_Synthase_Kinase_3Beta-_re69
control type: INHIBITION
controller: Complex (Dishevelled/Casein Kinase 2/ Beta-Arrestin/Frodo/ FRAT)

ISWI chromatin-remodeling complex ATPase CHR17
type: ProteinReference
xref: PTHR10799:SF975
xref: uniprot F4JY24 296
organism: Arabidopsis thaliana

uniprot H2QRN2 795
type: UnificationXref
id: H2QRN2
db: uniprot

PARTICIPANT STOICHIOMETRY re63 2513
type: Stoichiometry
physical entity: Wnt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re63 2512
type: Stoichiometry
physical entity: Wnt
stoichiometric coefficient: 1.0

Uncharacterized protein
type: DnaReference
xref: PTHR45615:SF26
organism: 9031

uniprot A0A1D5R985 1644
type: UnificationXref
id: A0A1D5R985
db: uniprot

uniprot F6TQC1 304
type: UnificationXref
id: F6TQC1
db: uniprot

Shaggy-related protein kinase theta
type: ProteinReference
xref: uniprot Q96287 1025
organism: Arabidopsis thaliana

uniprot Q9UBT7 2039
type: UnificationXref
id: Q9UBT7
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: uniprot Q90XF2 1706
xref: PTHR24356:SF214
organism: Danio rerio

ncbitaxon 284811 2090
type: UnificationXref
id: 284811
db: ncbitaxon

TCF
type: Protein
entity reference: TCF
feature: TCF s93 sa63 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s93 sa63 2256
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Protocadherin-10
type: ProteinReference
xref: PTHR24028:SF0
xref: uniprot Q9P2E7 948
organism: Homo sapiens

Casein kinase 1-like protein 2
type: ProteinReference
xref: PTHR11909:SF409
xref: uniprot Q9CAI5 1862
organism: Arabidopsis thaliana

SFRP1 isoform 1
type: ProteinReference
xref: PTHR11309:SF87
xref: uniprot H2R9U6 235
organism: Pan troglodytes

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P11881 32
xref: PTHR13715:SF52
organism: Mus musculus

uniprot Q14934 1486
type: UnificationXref
id: Q14934
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot F6W548 1935
organism: Macaca mulatta

uniprot Q9FML2 2102
type: UnificationXref
id: Q9FML2
db: uniprot

Segment polarity protein dishevelled homolog DVL-2
type: ProteinReference
xref: uniprot Q60838 1395
xref: PTHR10878:SF8
organism: Mus musculus

uniprot Q7Q042 1704
type: UnificationXref
id: Q7Q042
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UBJ7 723
xref: PTHR24027:SF99
organism: Monodelphis domestica

AGAP007924-PA (Fragment)
type: ProteinReference
xref: PTHR24026:SF76
xref: uniprot Q7Q3K5 885
organism: Anopheles gambiae

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot Q74Z12 2089
organism: 284811

Cadherin 15
type: ProteinReference
xref: PTHR24027:SF300
xref: uniprot Q75NI5 875
organism: Rattus norvegicus

uniprot E2QW66 1037
type: UnificationXref
id: E2QW66
db: uniprot

serine33 Beta Catenin s69 sa29 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s69 sa29 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

uniprot A0A3Q1NGS8 1596
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

uniprot P25439 355
type: UnificationXref
id: P25439
db: uniprot

C-terminal-binding protein 1
type: ProteinReference
xref: PTHR46029:SF2
xref: uniprot O88712 609
organism: Mus musculus

uniprot P16520 1618
type: UnificationXref
id: P16520
db: uniprot

Catenin alpha 1
type: ProteinReference
xref: uniprot E2R9S7 2014
xref: PTHR18914:SF24
organism: Canis lupus familiaris

uniprot A5PKF6 266
type: UnificationXref
id: A5PKF6
db: uniprot

uniprot Q8LAS7 1367
type: UnificationXref
id: Q8LAS7
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot F6XMD3 1182
organism: Xenopus tropicalis

uniprot P48454 1332
type: UnificationXref
id: P48454
db: uniprot

Lymphocyte-specific helicase
type: ProteinReference
xref: uniprot Q60848 393
xref: PTHR47161:SF1
organism: Mus musculus

Catenin (Cadherin-associated protein), alpha
type: ProteinReference
xref: PTHR18914:SF24
xref: uniprot Q9PVF8 2038
organism: Danio rerio

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF88
xref: uniprot F6SXE3 1176
organism: Monodelphis domestica

AGAP007905-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q3J3 884
organism: Anopheles gambiae

uniprot H2QQ80 326
type: UnificationXref
id: H2QQ80
db: uniprot

PARTICIPANT STOICHIOMETRY r110 2454
type: Stoichiometry
physical entity: PI(4,5)P2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r110 2456
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r110 2455
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QC78 51
xref: PTHR22611:SF1
organism: Macaca mulatta

Frizzled-4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot Q9NBW1 143
organism: Drosophila melanogaster

Homeobox protein engrailed-like
type: DnaReference
xref: PTHR24341:SF4
organism: Bos taurus

ATP
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7HPS9 1911
type: UnificationXref
id: F7HPS9
db: uniprot

PP2A s190 sa105 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase spe-6
type: ProteinReference
xref: PTHR11909:SF72
xref: uniprot Q95PZ9 1860
organism: Caenorhabditis elegans

Protein CBR-KIN-19
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot A8XX71 1793
organism: Caenorhabditis briggsae

uniprot E2R9F8 155
type: UnificationXref
id: E2R9F8
db: uniprot

uniprot F6R812 1799
type: UnificationXref
id: F6R812
db: uniprot

Transducin like Enhance of Split 1 3 s56 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Transducin-like Enhance of Split 1-3
stoichiometric coefficient: 1.0

Protein Wnt-3a
type: ProteinReference
xref: uniprot Q2LMP1 1259
xref: PTHR12027:SF88
organism: 9031

uniprot F1MXP9 707
type: UnificationXref
id: F1MXP9
db: uniprot

PTHR12533:SF6
type: RelationshipXref
id: PTHR12533:SF6
db: PANTHER Family
relationship type: By Homology

PTHR12533:SF5
type: RelationshipXref
id: PTHR12533:SF5
db: PANTHER Family
relationship type: By Homology

Serine45 Beta Catenin s193 sa108 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s193 sa108 rs1 Serine45
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

uniprot A0A3Q2UDY7 262
type: UnificationXref
id: A0A3Q2UDY7
db: uniprot

PP2A
type: ProteinReference
xref: P01438
standard name: Protein phosphatase 2A
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein phosphatase 2A Synonym: PP2A,PP2A B56 subunit,Protein Phosphatase 2A Accession: P01438
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.PP2A
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
member entity reference: Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1
member entity reference: Q6PD03
member entity reference: Serine/threonine protein phosphatase 2A regulatory subunit
member entity reference: Serine/threonine-protein phosphatase
member entity reference: D3ZDI7
member entity reference: Q803G3
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
member entity reference: F7G755
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
member entity reference: H2Q411
member entity reference: P63331
member entity reference: E1C5A3
member entity reference: P63330
member entity reference: Q6PD28
member entity reference: A0A3Q1MM63
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
member entity reference: P67775
member entity reference: P67774
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
member entity reference: F6X0X1
member entity reference: F6PKB8
member entity reference: H2QT14
member entity reference: F1N1S8
member entity reference: Q14738
member entity reference: Q13362
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
member entity reference: K9J7P6
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

PTHR12533:SF4
type: RelationshipXref
id: PTHR12533:SF4
db: PANTHER Family
relationship type: By Homology

Beta Catenin s117 sa89 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Transducin-like enhancer protein 6
type: ProteinReference
xref: PTHR10814:SF2
xref: uniprot Q9H808 495
organism: Homo sapiens

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot F6PG65 176
xref: PTHR24270:SF12
organism: Monodelphis domestica

Secreted frizzled-related protein 1
type: ProteinReference
xref: PTHR11309:SF87
xref: uniprot F1LLX7 228
organism: Rattus norvegicus

Axin-2
type: DnaReference
xref: PTHR46102:SF1
organism: Mus musculus

Beta Catenin s184 sa100 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

PTHR13715:SF51
type: RelationshipXref
id: PTHR13715:SF51
db: PANTHER Family
relationship type: By Homology

Dickkopf
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa3 2216
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR13715:SF53
type: RelationshipXref
id: PTHR13715:SF53
db: PANTHER Family
relationship type: By Homology

F-box and WD repeat domain-containing 11
type: ProteinReference
xref: PTHR44129:SF4
xref: uniprot A0A0G2JVE0 1511
organism: Rattus norvegicus

Serine/threonine-protein kinase RIM11/MSD1
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot P38615 1019
organism: Saccharomyces cerevisiae

uniprot Q61016 1978
type: UnificationXref
id: Q61016
db: uniprot

uniprot F6WHM2 1179
type: UnificationXref
id: F6WHM2
db: uniprot

uniprot P38930 1751
type: UnificationXref
id: P38930
db: uniprot

Protein Wnt-2b
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot Q93097 1271
organism: Homo sapiens

Protein Wnt-8b
type: ProteinReference
xref: uniprot Q93098 1272
xref: PTHR12027:SF94
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot A0A1D5NXQ4 1785
organism: 9031

Frizzled-10
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot Q9ULW2 149
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot E2RJB3 1926
organism: Canis lupus familiaris

PTHR47157:SF1
type: RelationshipXref
id: PTHR47157:SF1
db: PANTHER Family
relationship type: By Homology

Complex (Galpha/Phospholipase C)
type: Complex
component stoichiometry: Galpha s156 sa75 STOICHIOMETRY ID COMPLEX
component stoichiometry: Phospholipase C s157 sa76 STOICHIOMETRY ID COMPLEX
component: Galpha
component: Phospholipase C
feature: COMPLEX BINDING FEATURE s203 a463 2155
feature: COMPLEX BINDING FEATURE s203 a463 2157
feature: ACTIVE 50
cellular location: plasma membrane

uniprot Q7Q3J3 884
type: UnificationXref
id: Q7Q3J3
db: uniprot

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: uniprot Q14934 1486
xref: PTHR12533:SF11
organism: Homo sapiens

uniprot E2RM28 686
type: UnificationXref
id: E2RM28
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CQY4 312
xref: PTHR45766:SF3
organism: Macaca mulatta

uniprot F1PV54 544
type: UnificationXref
id: F1PV54
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot P18266 1018
organism: Rattus norvegicus

Frizzled class receptor 10
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot Q6GL20 130
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY re65 2500
type: Stoichiometry
physical entity: Casein Kinase 1
stoichiometric coefficient: 1.0

Dishevelled segment polarity protein 1
type: ProteinReference
xref: PTHR10878:SF5
xref: uniprot E2QY91 1379
organism: Canis lupus familiaris

Frizzled-4
type: ProteinReference
xref: uniprot Q9ULV1 148
xref: PTHR11309:SF23
organism: Homo sapiens

C-terminal binding protein 1
type: ProteinReference
xref: uniprot F6YV22 605
xref: PTHR46029:SF2
organism: 9258

F-box and WD repeat domain containing 11
type: ProteinReference
xref: uniprot F6YUQ2 1522
xref: PTHR44129:SF4
organism: 9258

Axin s53 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VCS5 728
xref: PTHR24028:SF1
organism: Macaca mulatta

uniprot H2QSU0 28
type: UnificationXref
id: H2QSU0
db: uniprot

uniprot Q24214 1350
type: UnificationXref
id: Q24214
db: uniprot

uniprot F7EDR2 1052
type: UnificationXref
id: F7EDR2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE TRANSITION LEFT Nemo like Kinase- ATP-RIGHT ADP- Nemo like Kinase- r71
controller: TGFbetaactivated Kinase-1

uniprot F6PKB8 546
type: UnificationXref
id: F6PKB8
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot Q7ZUQ2 592
xref: PTHR10257:SF92
organism: Danio rerio

serine33 Beta Catenin s92 sa62 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s92 sa62 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

Segment polarity protein dishevelled homolog mig-5
type: ProteinReference
xref: PTHR10878:SF24
xref: uniprot Q22227 1393
organism: Caenorhabditis elegans

Cadherin 6
type: ProteinReference
xref: uniprot F7BE94 747
xref: PTHR24027:SF322
organism: Xenopus tropicalis

Chromatin-remodeling complex ATPase chain Iswi
type: ProteinReference
xref: PTHR10799:SF967
xref: uniprot Q24368 382
organism: Drosophila melanogaster

uniprot Q9ULV1 148
type: UnificationXref
id: Q9ULV1
db: uniprot

Protein CBR-CWN-1
type: ProteinReference
xref: uniprot A8X402 1141
xref: PTHR12027:SF101
organism: Caenorhabditis briggsae

Dishevelled
type: ProteinReference
xref: P01447
comment: ENTITY_REFERENCE_NOTES= Long Name: Dishevelled Synonym: Dvl Accession: P01447
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Dishevelled
member entity reference: dishevelled homolog
member entity reference: Dishevelled segment polarity protein 3
member entity reference: Dishevelled segment polarity protein 2
member entity reference: Segment polarity protein dishevelled homolog DVL-1
member entity reference: Uncharacterized protein
member entity reference: Dishevelled segment polarity protein 1
member entity reference: Segment polarity protein dishevelled homolog DVL-3
member entity reference: H2QC24
member entity reference: Dishevelled segment polarity protein 3a
member entity reference: O14641
member entity reference: DiSHevelled related
member entity reference: Segment polarity protein dishevelled homolog mig-5
member entity reference: DVL3 isoform 1
member entity reference: D4ADV8
member entity reference: Segment polarity protein dishevelled
member entity reference: Segment polarity protein dishevelled homolog DVL-2
member entity reference: F1MMW6

uniprot D4A497 666
type: UnificationXref
id: D4A497
db: uniprot

uniprot O88895 2071
type: UnificationXref
id: O88895
db: uniprot

F-box and WD repeat domain containing 11
type: ProteinReference
xref: PTHR44129:SF4
xref: uniprot A0A3Q1M118 1517
organism: Bos taurus

CREB-binding protein isoform a
type: ProteinReference
xref: uniprot F6RRA8 1404
xref: PTHR13808:SF34
organism: Macaca mulatta

uniprot K7B016 207
type: UnificationXref
id: K7B016
db: uniprot

ncbitaxon 224324 1996
type: UnificationXref
id: 224324
db: ncbitaxon

uniprot Q0VCX4 195
type: UnificationXref
id: Q0VCX4
db: uniprot

uniprot Q3SWX5 852
type: UnificationXref
id: Q3SWX5
db: uniprot

Catenin (Cadherin-associated protein), beta 1, 88kDa
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot Q28GC2 196
organism: Xenopus tropicalis

uniprot A0A3Q2U0G2 1092
type: UnificationXref
id: A0A3Q2U0G2
db: uniprot

uniprot E1BA29 1442
type: UnificationXref
id: E1BA29
db: uniprot

Adenomatous Polyposis Coli
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa31 2174
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot F6XMN6 1660
organism: Canis lupus familiaris

Transcription factor 7-like 1
type: ProteinReference
xref: uniprot Q6GL68 512
xref: PTHR10373:SF25
organism: Xenopus tropicalis

uniprot H2R3U6 332
type: UnificationXref
id: H2R3U6
db: uniprot

uniprot Q06486 1833
type: UnificationXref
id: Q06486
db: uniprot

Wnt
type: Protein
entity reference: Wnt
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F1N2V3 1443
type: UnificationXref
id: F1N2V3
db: uniprot

uniprot A0A2I3SKD1 599
type: UnificationXref
id: A0A2I3SKD1
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot E2RJ59 1306
xref: PTHR45673:SF7
organism: Canis lupus familiaris

uniprot A0A2I3TJM5 644
type: UnificationXref
id: A0A2I3TJM5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF91
xref: uniprot F6ZW11 742
organism: Macaca mulatta

IDA
type: EvidenceCodeVocabulary

Frizzled s14 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Frizzled
stoichiometric coefficient: 1.0

LRP5/6
type: Protein
entity reference: LRP5/6
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q91XW9 912
type: UnificationXref
id: Q91XW9
db: uniprot

uniprot F7DJA6 1289
type: UnificationXref
id: F7DJA6
db: uniprot

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa25 2150
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F7C5Z9 552
xref: PTHR10257:SF89
organism: Monodelphis domestica

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF75
xref: uniprot A0A3Q1MPF5 1135
organism: Bos taurus

uniprot F7E905 1406
type: UnificationXref
id: F7E905
db: uniprot

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
type: ProteinReference
xref: uniprot E2RJ89 282
xref: PTHR10799:SF76
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 1626
xref: PTHR19850:SF27
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 1625
xref: PTHR19850:SF29
organism: Rattus norvegicus

uniprot Q9Y5E2 970
type: UnificationXref
id: Q9Y5E2
db: uniprot

uniprot P41877 360
type: UnificationXref
id: P41877
db: uniprot

uniprot F6WVD0 1731
type: UnificationXref
id: F6WVD0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot H9FVW1 1104
organism: Macaca mulatta

uniprot Q95PZ9 1860
type: UnificationXref
id: Q95PZ9
db: uniprot

uniprot F6VPH2 1801
type: UnificationXref
id: F6VPH2
db: uniprot

uniprot F6YZA3 1939
type: UnificationXref
id: F6YZA3
db: uniprot

Threonine41 Beta Catenin s64 sa24 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s64 sa24 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

uniprot Q6P365 587
type: UnificationXref
id: Q6P365
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 1637
xref: PTHR19850:SF29
organism: Danio rerio

uniprot P22725 1227
type: UnificationXref
id: P22725
db: uniprot

uniprot Q8AXX6 595
type: UnificationXref
id: Q8AXX6
db: uniprot

AGAP010462-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PRH5 406
xref: PTHR10799:SF854
organism: Anopheles gambiae

uniprot Q3SX29 238
type: UnificationXref
id: Q3SX29
db: uniprot

Adenomatous Polyposis Coli
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s305 sa37 2224
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9H159 937
type: UnificationXref
id: Q9H159
db: uniprot

Secreted frizzled-related protein 3
type: ProteinReference
xref: uniprot Q95117 1891
xref: PTHR11309:SF97
organism: Bos taurus

STATE TRANSITION LEFT Complex Adenomatous Polyposis Coli Beta Catenin Axin PP2A Diversin Casein Kinase 1 - ATP-RIGHT ADP- Complex Adenomatous Polyposis Coli Beta Catenin Glycogen Synthase Kinase 3Beta Axin PP2A Diversin Casein Kinase 1 - r86
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 2527
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 2525
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 2528
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 2526
left: ATP
left: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Axin/PP2A/ Diversin/Casein Kinase 1)
display name: STATE_TRANSITION_LEFT__Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Axin_PP2A__Diversin_Casein_Kinase_1_-_ATP-RIGHT__ADP-_Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Glycogen_Synthase_Kinase_3Beta_Axin__PP2A_Diversin__Casein_Kinase_1_-_r86
interaction type: STATE_TRANSITION
right: ADP
right: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Glycogen Synthase Kinase-3Beta/Axin/ PP2A/Diversin/ Casein Kinase 1)

Uncharacterized protein
type: DnaReference
xref: PTHR11937:SF445
organism: Macaca mulatta

Transcriptional regulator
type: DnaReference
xref: PTHR45851:SF1
organism: Xenopus tropicalis

uniprot A9T4Y7 1716
type: UnificationXref
id: A9T4Y7
db: uniprot

uniprot F1P6U6 709
type: UnificationXref
id: F1P6U6
db: uniprot

Homeobox protein engrailed-2a
type: DnaReference
xref: PTHR24341:SF5
organism: Danio rerio

SWI/SNF family helicase
type: ProteinReference
xref: uniprot O84559 348
xref: PTHR10799:SF987
organism: Chlamydia trachomatis

Uncharacterized protein
type: ProteinReference
xref: PTHR24054:SF16
xref: uniprot F6VCI6 1730
organism: Monodelphis domestica

uniprot Q71M42 874
type: UnificationXref
id: Q71M42
db: uniprot

uniprot P51532 364
type: UnificationXref
id: P51532
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot Q7QCP8 1705
xref: PTHR24356:SF240
organism: Anopheles gambiae

uniprot F1MAD0 171
type: UnificationXref
id: F1MAD0
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot H2Q8X8 560
xref: PTHR10257:SF19
organism: Pan troglodytes

G1/S-specific cyclin-D1
type: DnaReference
xref: PTHR10177:SF67
organism: Danio rerio

uniprot Q8CFX3 894
type: UnificationXref
id: Q8CFX3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot F1MJS2 504
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot F6V461 1933
organism: 9258

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: PTHR13809:SF25
xref: uniprot P59768 1964
organism: Homo sapiens

By Homology
type: RelationshipTypeVocabulary

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
type: ProteinReference
xref: PTHR10019:SF5
xref: uniprot Q4KLI0 385
organism: Rattus norvegicus

uniprot H2QYR2 1570
type: UnificationXref
id: H2QYR2
db: uniprot

Myosin heavy chain 7B
type: DnaReference
xref: PTHR45615:SF29
organism: Bos taurus

Casein kinase 2 beta
type: ProteinReference
xref: uniprot A0A2I3TLD4 1709
xref: PTHR11740:SF0
organism: Pan troglodytes

Uncharacterized ATP-dependent helicase IRC5
type: ProteinReference
xref: uniprot P43610 362
xref: PTHR10799:SF923
organism: Saccharomyces cerevisiae

uniprot P34722 1687
type: UnificationXref
id: P34722
db: uniprot

Cadherin s304 sa124 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cadherin
stoichiometric coefficient: 1.0

Nuclear factor of activated T-cells, cytoplasmic 1
type: ProteinReference
xref: PTHR12533:SF5
xref: uniprot O95644 1482
organism: Homo sapiens

uniprot F7F4A2 1541
type: UnificationXref
id: F7F4A2
db: uniprot

uniprot P11017 1617
type: UnificationXref
id: P11017
db: uniprot

uniprot Q02248 194
type: UnificationXref
id: Q02248
db: uniprot

Chromatin structure-remodeling complex protein RSC8
type: ProteinReference
xref: uniprot P43609 361
xref: PTHR12802:SF65
organism: Saccharomyces cerevisiae

uniprot F6RRA8 1404
type: UnificationXref
id: F6RRA8
db: uniprot

uniprot Q91Y04 923
type: UnificationXref
id: Q91Y04
db: uniprot

uniprot Q9XFH4 450
type: UnificationXref
id: Q9XFH4
db: uniprot

PTHR22846:SF52
type: RelationshipXref
id: PTHR22846:SF52
db: PANTHER Family
relationship type: By Homology

Axin-1
type: DnaReference
xref: PTHR46102:SF3
organism: 9031

G1/S-specific cyclin-D1
type: DnaReference
xref: PTHR10177:SF67
organism: Macaca mulatta

uniprot P05771 1676
type: UnificationXref
id: P05771
db: uniprot

uniprot A8XX71 1793
type: UnificationXref
id: A8XX71
db: uniprot

uniprot F6Y4F1 739
type: UnificationXref
id: F6Y4F1
db: uniprot

PTHR22846:SF60
type: RelationshipXref
id: PTHR22846:SF60
db: PANTHER Family
relationship type: By Homology

Cadherin-20
type: ProteinReference
xref: PTHR24027:SF84
xref: uniprot Q9Z0M3 1008
organism: Mus musculus

Complex (betaTrCP/Beta-Catenin)
type: Complex
component stoichiometry: betaTrCP s205 sa111 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Catenin s206 sa112 STOICHIOMETRY ID COMPLEX
component: Beta-Catenin
component: betaTrCP s205 sa111
feature: COMPLEX BINDING FEATURE s267 a557 2371
feature: COMPLEX BINDING FEATURE s267 a557 2369
cellular location: plasma membrane

AGAP003579-PA
type: ProteinReference
xref: PTHR24028:SF146
xref: uniprot Q7QAQ8 886
organism: Anopheles gambiae

Adenylosuccinate synthetase isozyme 1
type: DnaReference
xref: PTHR11846:SF2
organism: Monodelphis domestica

Calcineurin B-like protein 7
type: ProteinReference
xref: uniprot Q9SUA6 1371
xref: PTHR23056:SF90
organism: Arabidopsis thaliana

uniprot P56705 1251
type: UnificationXref
id: P56705
db: uniprot

uniprot F6T7C8 302
type: UnificationXref
id: F6T7C8
db: uniprot

PTHR13703:SF61
type: RelationshipXref
id: PTHR13703:SF61
db: PANTHER Family
relationship type: By Homology

Transducin (beta)-like 1 X-linked receptor 1b
type: ProteinReference
xref: uniprot A5WVU0 1492
organism: Danio rerio

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot G3V7U3 1196
organism: Rattus norvegicus

uniprot C3ZSF0 1600
type: UnificationXref
id: C3ZSF0
db: uniprot

uniprot Q8BK63 1846
type: UnificationXref
id: Q8BK63
db: uniprot

PTHR24027:SF290
type: RelationshipXref
id: PTHR24027:SF290
db: PANTHER Family
relationship type: By Homology

Casein kinase 1 alpha 1
type: ProteinReference
xref: PTHR11909:SF84
xref: uniprot A0A2I3RLP7 1787
organism: Pan troglodytes

Frizzled-4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot Q9IA05 141
organism: 9031

uniprot D4ADS5 1895
type: UnificationXref
id: D4ADS5
db: uniprot

uniprot A0A1D8PSA6 2045
type: UnificationXref
id: A0A1D8PSA6
db: uniprot

Beta-Arrestin
type: ProteinReference
xref: P01456
standard name: beta-arrestin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Beta-Arrestin
comment: ENTITY_REFERENCE_NOTES= Long Name: Beta-Arrestin Synonym: BetaArr1,BetaArr2 Accession: P01456
member entity reference: S-antigen visual arrestin
member entity reference: S-arrestin
member entity reference: Beta-arrestin-2
member entity reference: Beta-arrestin-1
member entity reference: Arrestin-C
member entity reference: A0A1D5RD22
member entity reference: Phosrestin-1
member entity reference: Q91YI4
member entity reference: Beta-arrestin arr-1
member entity reference: Arrestin, beta 1
member entity reference: AGAP011360-PA (Fragment)
member entity reference: Uncharacterized protein
member entity reference: H2QBY1
member entity reference: Arrestin beta 1
member entity reference: AGAP010134-PA
member entity reference: Protein CBR-ARR-1
member entity reference: Arrestin, beta 2a
member entity reference: Phosrestin-2
member entity reference: AGAP006263-PA
member entity reference: Arrestin beta 2
member entity reference: ARR3 isoform 1
member entity reference: Kurtz arrestin
member entity reference: ARRB1 isoform 1

Ebi
type: Protein
entity reference: Ebi
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa8 2152
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR22846:SF40
type: RelationshipXref
id: PTHR22846:SF40
db: PANTHER Family
relationship type: By Homology

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 1
type: ProteinReference
xref: uniprot F6VTC2 306
xref: PTHR13844:SF1
organism: Xenopus tropicalis

NFAT s230 a494 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

uniprot P05126 1672
type: UnificationXref
id: P05126
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12656:SF12
xref: uniprot A0A3Q1M2B9 258
organism: Bos taurus

PTHR19854:SF16
type: RelationshipXref
id: PTHR19854:SF16
db: PANTHER Family
relationship type: By Homology

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F7BDU6 1539
xref: PTHR13703:SF45
organism: Xenopus tropicalis

Protein kinase C eta type
type: ProteinReference
xref: uniprot P23298 1684
xref: PTHR24356:SF192
organism: Mus musculus

uniprot A0A2I3SHA1 640
type: UnificationXref
id: A0A2I3SHA1
db: uniprot

Frizzled-4
type: ProteinReference
xref: uniprot A0A1D5Q1B1 65
xref: PTHR11309:SF23
organism: Macaca mulatta

Casein kinase I isoform alpha-like
type: ProteinReference
xref: uniprot Q8N752 1853
xref: PTHR11909:SF139
organism: Homo sapiens

Casein kinase I homolog 2
type: ProteinReference
xref: uniprot P23292 1815
xref: PTHR11909:SF155
organism: Saccharomyces cerevisiae

Actin, alpha cardiac muscle 1
type: DnaReference
xref: PTHR11937:SF176
organism: Xenopus tropicalis

uniprot Q9Y5I4 1006
type: UnificationXref
id: Q9Y5I4
db: uniprot

Homeobox protein engrailed-1a
type: DnaReference
xref: PTHR24341:SF4
organism: Danio rerio

PTHR13703:SF36
type: RelationshipXref
id: PTHR13703:SF36
db: PANTHER Family
relationship type: By Homology

uniprot P48615 1243
type: UnificationXref
id: P48615
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R774 454
xref: PTHR10814:SF24
organism: Macaca mulatta

HETERODIMER_ASSOCIATION_LEFT__Bcl9-_Complex__TCF_Smad4__Beta_Catenin_-RIGHT__Complex__TCF_Beta_Catenin__Smad4_Bcl9_-_r64
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 2462
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 2460
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 2461
left: Bcl9 s170 a416
left: Complex (TCF/Smad4/ Beta-Catenin)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TCF/Beta-Catenin/ Smad4/Bcl9)

PARTICIPANT STOICHIOMETRY r90 2477
type: Stoichiometry
physical entity: Ubiquitin s268 a558
stoichiometric coefficient: 1.0

uniprot Q7Q1M9 883
type: UnificationXref
id: Q7Q1M9
db: uniprot

PARTICIPANT STOICHIOMETRY r90 2479
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Axin/ PP2A/Diversin/ Casein Kinase 1/Beta-Catenin/ betaTrCP/Glycogen Synthase Kinase-3Beta)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r90 2478
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Axin/ PP2A/Diversin/ Casein Kinase 1/Beta-Catenin/ betaTrCP/Glycogen Synthase Kinase-3Beta)
stoichiometric coefficient: 1.0

TCF s197 a450 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Serine/threonine-protein phosphatase 2B catalytic subunit A1
type: ProteinReference
xref: uniprot P23287 1326
xref: PTHR45673:SF1
organism: Saccharomyces cerevisiae

Secreted frizzled related protein 4
type: ProteinReference
xref: uniprot E2QYI0 1878
xref: PTHR11309:SF7
organism: Canis lupus familiaris

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot J9NUI0 2064
organism: Canis lupus familiaris

uniprot Q90XF2 1706
type: UnificationXref
id: Q90XF2
db: uniprot

Diversin
type: Protein
entity reference: Diversin
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa33 2178
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR13703:SF23
type: RelationshipXref
id: PTHR13703:SF23
db: PANTHER Family
relationship type: By Homology

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (Predicted), isoform CRA_a
type: ProteinReference
xref: uniprot F1LNL2 287
xref: PTHR10799:SF879
organism: Rattus norvegicus

uniprot F7G3J2 1614
type: UnificationXref
id: F7G3J2
db: uniprot

Protein Wnt-4
type: ProteinReference
xref: PTHR12027:SF111
xref: uniprot P40589 1238
organism: Drosophila melanogaster

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P24723 1685
organism: Homo sapiens

uniprot P17252 1682
type: UnificationXref
id: P17252
db: uniprot

uniprot F7GH85 1191
type: UnificationXref
id: F7GH85
db: uniprot

TCF s93 sa63 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: uniprot F7D4J8 1186
xref: PTHR12027:SF94
organism: Monodelphis domestica

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot F5HH30 1605
organism: Neurospora crassa

uniprot A0A3Q1LJY1 458
type: UnificationXref
id: A0A3Q1LJY1
db: uniprot

PTHR11937:SF46
type: RelationshipXref
id: PTHR11937:SF46
db: PANTHER Family
relationship type: By Homology

uniprot P34545 1409
type: UnificationXref
id: P34545
db: uniprot

Endothelin-1
type: DnaReference
xref: PTHR13874:SF10
organism: Homo sapiens

uniprot E2RH98 1164
type: UnificationXref
id: E2RH98
db: uniprot

uniprot P70539 1074
type: UnificationXref
id: P70539
db: uniprot

uniprot E9GYL6 1307
type: UnificationXref
id: E9GYL6
db: uniprot

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: COMPLEX PARTICIPANT BINDING FEATURE s206 sa112 2372
feature: Threonine41 Beta Catenin s206 sa112 rs4
feature: Serine35 Beta Catenin s206 sa112 rs2
feature: Serine45 Beta Catenin s206 sa112 rs1
feature: Beta Catenin s206 sa112 rs5
feature: serine33 Beta Catenin s206 sa112 rs3
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

CaDHerin family
type: ProteinReference
xref: uniprot Q19194 847
xref: PTHR24026:SF97
organism: Caenorhabditis elegans

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
type: ProteinReference
xref: uniprot Q12824 376
xref: PTHR10019:SF5
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF7
xref: uniprot G3V819 1197
organism: Rattus norvegicus

uniprot O88327 2026
type: UnificationXref
id: O88327
db: uniprot

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily e, member 1
type: ProteinReference
xref: uniprot Q6GLG1 397
xref: PTHR46232:SF1
organism: Xenopus tropicalis

uniprot F1REQ8 716
type: UnificationXref
id: F1REQ8
db: uniprot

Complex (Frizzled/Wnt/ LRP5/6)
type: Complex
component stoichiometry: Wnt s15 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: LRP5 6 s17 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Frizzled s14 sa5 STOICHIOMETRY ID COMPLEX
component: Frizzled
component: LRP5/6
component: Wnt
feature: COMPLEX BINDING FEATURE s27 a28 2321
feature: ACTIVE 50
feature: COMPLEX BINDING FEATURE s27 a28 2317
feature: COMPLEX BINDING FEATURE s27 a28 2319
cellular location: plasma membrane

Catenin alpha like 1
type: ProteinReference
xref: PTHR46342:SF1
xref: uniprot H2QXN7 2025
organism: Pan troglodytes

Beta-Arrestin
type: Protein
entity reference: Beta-Arrestin
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa15 2104
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P49339 1245
type: UnificationXref
id: P49339
db: uniprot

Chromodomain-helicase-DNA-binding protein 1-like
type: ProteinReference
xref: uniprot Q86WJ1 413
xref: PTHR47157:SF1
organism: Homo sapiens

Cadherin-12
type: ProteinReference
xref: PTHR24027:SF96
xref: uniprot Q5RJH3 870
organism: Mus musculus

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot A0A1D5QUK7 1031
organism: Macaca mulatta

uniprot E9HGM4 1795
type: UnificationXref
id: E9HGM4
db: uniprot

Threonine41 Beta Catenin s88 sa58 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s88 sa58 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

uniprot Q20595 615
type: UnificationXref
id: Q20595
db: uniprot

uniprot F7H7P6 1192
type: UnificationXref
id: F7H7P6
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 535

uniprot E2R9I5 280
type: UnificationXref
id: E2R9I5
db: uniprot

uniprot F1PR63 2052
type: UnificationXref
id: F1PR63
db: uniprot

uniprot F1LXN4 695
type: UnificationXref
id: F1LXN4
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot A0A2I3SR38 1646
organism: Pan troglodytes

uniprot P30678 1458
type: UnificationXref
id: P30678
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot F7GWP9 556
organism: Macaca mulatta

Protocadherin 7
type: ProteinReference
xref: uniprot E1BCK4 672
xref: PTHR24028:SF253
organism: Bos taurus

Transcription activator BRG1
type: ProteinReference
xref: PTHR10799:SF76
xref: uniprot P51532 364
organism: Homo sapiens

Probable global transcription activator SNF2L2
type: ProteinReference
xref: uniprot P51531 363
xref: PTHR10799:SF541
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QLT3 2005
organism: Macaca mulatta

uniprot A0A3Q1MZ99 502
type: UnificationXref
id: A0A3Q1MZ99
db: uniprot

uniprot Q9QXQ5 1278
type: UnificationXref
id: Q9QXQ5
db: uniprot

PPARD isoform 1
type: DnaReference
xref: PTHR24082:SF15
organism: Pan troglodytes

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot Q6GLE6 586
organism: Xenopus tropicalis

uniprot P63319 1691
type: UnificationXref
id: P63319
db: uniprot

PTHR24027:SF267
type: RelationshipXref
id: PTHR24027:SF267
db: PANTHER Family
relationship type: By Homology

Protocadherin 1
type: ProteinReference
xref: uniprot F6ZXH1 743
xref: PTHR24028:SF247
organism: Xenopus tropicalis

PTHR11792:SF20
type: RelationshipXref
id: PTHR11792:SF20
db: PANTHER Family
relationship type: By Homology

PTHR11792:SF22
type: RelationshipXref
id: PTHR11792:SF22
db: PANTHER Family
relationship type: By Homology

PTHR11792:SF23
type: RelationshipXref
id: PTHR11792:SF23
db: PANTHER Family
relationship type: By Homology

uniprot P49674 1827
type: UnificationXref
id: P49674
db: uniprot

Wnt s15 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Wnt
stoichiometric coefficient: 1.0

Cadherin-17
type: ProteinReference
xref: PTHR24027:SF419
xref: uniprot Q12864 844
organism: Homo sapiens

uniprot F6RN85 1728
type: UnificationXref
id: F6RN85
db: uniprot

uniprot Q7Q5D2 2094
type: UnificationXref
id: Q7Q5D2
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot F7HJS7 1056
organism: Macaca mulatta

Secreted frizzled-related protein 2
type: ProteinReference
xref: PTHR11309:SF45
xref: uniprot Q9IA96 244
organism: 9031

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot P43639 1756
xref: PTHR11740:SF24
organism: Saccharomyces cerevisiae

uniprot F6XL57 551
type: UnificationXref
id: F6XL57
db: uniprot

uniprot F7CC58 1523
type: UnificationXref
id: F7CC58
db: uniprot

Myosin heavy chain 7B
type: DnaReference
xref: PTHR45615:SF29
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 1635
xref: PTHR19850:SF25
organism: 214684

uniprot F6PGQ1 1014
type: UnificationXref
id: F6PGQ1
db: uniprot

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 1603
xref: PTHR19850:SF25
organism: 6669

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A1D5R6N7 524
xref: PTHR10257:SF19
organism: Macaca mulatta

uniprot F6VPY1 1934
type: UnificationXref
id: F6VPY1
db: uniprot

AT-rich interaction domain 1A
type: ProteinReference
xref: PTHR12656:SF12
xref: uniprot F6T7C8 302
organism: Monodelphis domestica

uniprot E2RAF3 79
type: UnificationXref
id: E2RAF3
db: uniprot

uniprot Q91XZ6 916
type: UnificationXref
id: Q91XZ6
db: uniprot

PP2A s42 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

Histone acetyltransferase p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot F6T7D0 1405
organism: Macaca mulatta

PTHR24027:SF272
type: RelationshipXref
id: PTHR24027:SF272
db: PANTHER Family
relationship type: By Homology

Catenin alpha like 1
type: ProteinReference
xref: PTHR46342:SF1
xref: uniprot F1PPY7 2015
organism: Canis lupus familiaris

PTHR24027:SF273
type: RelationshipXref
id: PTHR24027:SF273
db: PANTHER Family
relationship type: By Homology

Frizzled class receptor 1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot F7E9U1 99
organism: Monodelphis domestica

uniprot Q8BNA6 892
type: UnificationXref
id: Q8BNA6
db: uniprot

uniprot Q8NEV1 1777
type: UnificationXref
id: Q8NEV1
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot F2Z4P5 1311
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7AQR3 1445
organism: Macaca mulatta

uniprot D3ZFQ5 663
type: UnificationXref
id: D3ZFQ5
db: uniprot

Follistatin-related protein 1
type: ProteinReference
xref: PTHR10913:SF13
xref: uniprot Q12841 1255
organism: Homo sapiens

uniprot O80507 1739
type: UnificationXref
id: O80507
db: uniprot

Histone acetyltransferase p300
type: ProteinReference
xref: uniprot B2RWS6 1400
xref: PTHR13808:SF29
organism: Mus musculus

Protein kinase C eta type
type: ProteinReference
xref: uniprot H2Q8F2 1667
xref: PTHR24356:SF192
organism: Pan troglodytes

uniprot F1MEW8 1166
type: UnificationXref
id: F1MEW8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A3Q2UD13 12
organism: 9031

PTHR11792:SF19
type: RelationshipXref
id: PTHR11792:SF19
db: PANTHER Family
relationship type: By Homology

PTHR11792:SF16
type: RelationshipXref
id: PTHR11792:SF16
db: PANTHER Family
relationship type: By Homology

PTHR11792:SF17
type: RelationshipXref
id: PTHR11792:SF17
db: PANTHER Family
relationship type: By Homology

uniprot Q9Z1B3 1123
type: UnificationXref
id: Q9Z1B3
db: uniprot

PTHR11792:SF15
type: RelationshipXref
id: PTHR11792:SF15
db: PANTHER Family
relationship type: By Homology

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: 36329

Cadherin-10
type: ProteinReference
xref: PTHR24027:SF290
xref: uniprot P70408 838
organism: Mus musculus

DACT1 isoform 5
type: ProteinReference
xref: uniprot H2Q8E0 2006
organism: Pan troglodytes

Cadherin-9
type: ProteinReference
xref: uniprot P70407 837
xref: PTHR24027:SF99
organism: Mus musculus

uniprot Q4JLT0 1263
type: UnificationXref
id: Q4JLT0
db: uniprot

Protocadherin beta-8
type: ProteinReference
xref: uniprot Q9UN66 955
xref: PTHR24028:SF150
organism: Homo sapiens

Protocadherin beta-10
type: ProteinReference
xref: uniprot Q9UN67 956
xref: PTHR24028:SF54
organism: Homo sapiens

Cadherin-18
type: ProteinReference
xref: PTHR24027:SF106
xref: uniprot Q08DJ5 843
organism: Bos taurus

serine33 Beta Catenin s141 sa126 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s141 sa126 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot F6YVV6 1316
organism: 9258

PCDHGC3 protein
type: ProteinReference
xref: uniprot A5D7F4 660
xref: PTHR24028:SF70
organism: Bos taurus

uniprot F7GNE4 190
type: UnificationXref
id: F7GNE4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3B5 1465
xref: PTHR10218:SF316
organism: 9031

Cerebus
type: ProteinReference
xref: P01445
standard name: Cerberus
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Cerebus
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Cerberus Synonym: Synonym not specified Accession: P01445
member entity reference: F7DJA6
member entity reference: Cerberus
member entity reference: Cerberus 1, DAN family BMP antagonist

Frizzled-3
type: ProteinReference
xref: uniprot F6QL95 88
xref: PTHR11309:SF22
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: uniprot F7A632 1661
xref: PTHR24356:SF158
organism: Monodelphis domestica

Siah-1
type: Protein
entity reference: Siah 1 PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s130 sa115 2208
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

NKD1 protein
type: ProteinReference
xref: uniprot A7Z042 53
xref: PTHR22611:SF2
organism: Bos taurus

uniprot F7FZG1 764
type: UnificationXref
id: F7FZG1
db: uniprot

uniprot P63218 1973
type: UnificationXref
id: P63218
db: uniprot

Cadherin-4
type: ProteinReference
xref: PTHR24027:SF81
xref: uniprot A0A1D5PQ72 625
organism: 9031

Frizzled-10
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot Q9PWH2 145
organism: 9031

Histone deacetylase phd1
type: ProteinReference
xref: PTHR10625:SF208
xref: uniprot O13298 2066
organism: 284812

uniprot E9PVD3 688
type: UnificationXref
id: E9PVD3
db: uniprot

uniprot B7QIS2 1719
type: UnificationXref
id: B7QIS2
db: uniprot

Casein kinase II subunit alpha
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot P18334 1745
organism: Caenorhabditis elegans

uniprot P53096 2073
type: UnificationXref
id: P53096
db: uniprot

PARTICIPANT STOICHIOMETRY r111 2449
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot Q3KRE3 1976
organism: Rattus norvegicus

Uncharacterized protein
type: DnaReference
xref: PTHR11937:SF176
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PGQ1 1014
xref: PTHR24057:SF8
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r111 2450
type: Stoichiometry
physical entity: Ca2 PLUS s294 a618
stoichiometric coefficient: 1.0

Uncharacterized protein
type: DnaReference
xref: PTHR45615:SF2
organism: Monodelphis domestica

uniprot E2QUH6 1565
type: UnificationXref
id: E2QUH6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RHZ1 1721
xref: PTHR24054:SF16
organism: Canis lupus familiaris

uniprot H2Q8X8 560
type: UnificationXref
id: H2Q8X8
db: uniprot

uniprot E2RNP2 1654
type: UnificationXref
id: E2RNP2
db: uniprot

Protocadherin beta 8
type: ProteinReference
xref: PTHR24028:SF90
xref: uniprot G3V8N7 780
organism: Rattus norvegicus

Transcription activator BRG1
type: ProteinReference
xref: PTHR10799:SF76
xref: uniprot A7Z019 268
organism: Bos taurus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
type: ProteinReference
xref: uniprot Q60996 584
xref: PTHR10257:SF19
organism: Mus musculus

uniprot P40232 1755
type: UnificationXref
id: P40232
db: uniprot

PTHR24027:SF311
type: RelationshipXref
id: PTHR24027:SF311
db: PANTHER Family
relationship type: By Homology

Protocadherin beta 22
type: ProteinReference
xref: PTHR24028:SF97
xref: uniprot G3V8N1 779
organism: Rattus norvegicus

uniprot F7A1M2 1538
type: UnificationXref
id: F7A1M2
db: uniprot

PTHR24027:SF319
type: RelationshipXref
id: PTHR24027:SF319
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r47 2399
type: Stoichiometry
physical entity: Complex Adenomatous Polyposis Coli Axin Beta Catenin PP2A s123 a275
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r47 2398
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r47 2397
type: Stoichiometry
physical entity: Complex Axin PP2A Adenomatous Polyposis Coli s121 a266
stoichiometric coefficient: 1.0

Histone deacetylase 3
type: ProteinReference
xref: PTHR10625:SF201
xref: uniprot O88895 2071
organism: Mus musculus

ncbitaxon 367110 1343
type: UnificationXref
id: 367110
db: ncbitaxon

Serine45 Beta Catenin s184 sa100 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s184 sa100 rs1 Serine45
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

uniprot F1P1X4 18
type: UnificationXref
id: F1P1X4
db: uniprot

PTHR24027:SF300
type: RelationshipXref
id: PTHR24027:SF300
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Z7T2 1479
xref: PTHR12533:SF5
organism: Macaca mulatta

uniprot O54949 1427
type: UnificationXref
id: O54949
db: uniprot

PTHR34491:SF33
type: RelationshipXref
id: PTHR34491:SF33
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot Q08DP7 575
xref: PTHR10257:SF4
organism: Bos taurus

FRAT
type: Protein
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (Predicted)
type: ProteinReference
xref: PTHR13844:SF1
xref: uniprot D3ZBS9 270
organism: Rattus norvegicus

uniprot F1PXA0 175
type: UnificationXref
id: F1PXA0
db: uniprot

uniprot A8XFP5 1713
type: UnificationXref
id: A8XFP5
db: uniprot

Complex (Adenomatous Polyposis Coli/Axin/ PP2A/Diversin/ Casein Kinase 1/Beta-Catenin/ betaTrCP/Glycogen Synthase Kinase-3Beta)
type: Complex
component stoichiometry: Glycogen Synthase Kinase 3Beta s204 sa110 STOICHIOMETRY ID COMPLEX
component stoichiometry: Casein Kinase 1 s192 sa107 STOICHIOMETRY ID COMPLEX
component stoichiometry: Axin s189 sa104 STOICHIOMETRY ID COMPLEX
component stoichiometry: PP2A s190 sa105 STOICHIOMETRY ID COMPLEX
component stoichiometry: Diversin s191 sa106 STOICHIOMETRY ID COMPLEX
component stoichiometry: Adenomatous Polyposis Coli s187 sa103 STOICHIOMETRY ID COMPLEX
component stoichiometry: betaTrCP s200 sa109 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Catenin s193 sa108 STOICHIOMETRY ID COMPLEX
component: Casein Kinase 1
component: Diversin
component: Glycogen Synthase Kinase 3Beta s204 sa110
component: Beta Catenin s193 sa108
component: PP2A
component: betaTrCP
component: Axin
component: Adenomatous Polyposis Coli
feature: COMPLEX BINDING FEATURE s266 a555 2131
feature: COMPLEX BINDING FEATURE s266 a555 2127
feature: COMPLEX BINDING FEATURE s266 a555 2123
feature: COMPLEX BINDING FEATURE s266 a555 2137
feature: COMPLEX BINDING FEATURE s266 a555 2129
feature: COMPLEX BINDING FEATURE s266 a555 2133
feature: COMPLEX BINDING FEATURE s266 a555 2135
feature: COMPLEX BINDING FEATURE s266 a555 2125
cellular location: plasma membrane

uniprot F6ZCW7 24
type: UnificationXref
id: F6ZCW7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18914:SF24
xref: uniprot A0A1D5QB83 2009
organism: Macaca mulatta

uniprot Q9Y5E8 976
type: UnificationXref
id: Q9Y5E8
db: uniprot

Protocadherin alpha-4
type: ProteinReference
xref: uniprot Q9UN74 961
xref: PTHR24028:SF82
organism: Homo sapiens

Protocadherin alpha-6
type: ProteinReference
xref: uniprot Q9UN73 960
xref: PTHR24028:SF265
organism: Homo sapiens

Protocadherin alpha-7
type: ProteinReference
xref: PTHR24028:SF225
xref: uniprot Q9UN72 959
organism: Homo sapiens

Protocadherin gamma-B4
type: ProteinReference
xref: PTHR24028:SF117
xref: uniprot Q9UN71 958
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 1921
xref: PTHR13809:SF6
organism: 9031

Protocadherin gamma-C3
type: ProteinReference
xref: uniprot Q9UN70 957
xref: PTHR24028:SF70
organism: Homo sapiens

uniprot Q924S4 1903
type: UnificationXref
id: Q924S4
db: uniprot

uniprot F6ZIZ9 1609
type: UnificationXref
id: F6ZIZ9
db: uniprot

uniprot F6Q932 1313
type: UnificationXref
id: F6Q932
db: uniprot

Protocadherin alpha-12
type: ProteinReference
xref: PTHR24028:SF76
xref: uniprot Q9UN75 962
organism: Homo sapiens

uniprot P40236 1823
type: UnificationXref
id: P40236
db: uniprot

CREB binding protein
type: ProteinReference
xref: uniprot K7DBC8 1408
xref: PTHR13808:SF34
organism: Pan troglodytes

Casein kinase 2, alpha prime polypeptide a
type: ProteinReference
xref: PTHR24054:SF34
xref: uniprot Q7ZU33 1774
organism: Danio rerio

uniprot O81275 1740
type: UnificationXref
id: O81275
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot G3V8K2 1949
organism: Rattus norvegicus

uniprot Q7X9V2 411
type: UnificationXref
id: Q7X9V2
db: uniprot

Fat protein
type: ProteinReference
xref: uniprot P73089 839
xref: PTHR24026:SF89
organism: Synechocystis

PARTICIPANT STOICHIOMETRY r69 2430
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 1598
xref: PTHR19850:SF25
organism: Sclerotinia sclerotiorum

uniprot F1PKX6 467
type: UnificationXref
id: F1PKX6
db: uniprot

Casein kinase II subunit alpha'
type: ProteinReference
xref: PTHR24054:SF34
xref: uniprot F1MJ55 1726
organism: Bos taurus

uniprot Q90275 904
type: UnificationXref
id: Q90275
db: uniprot

TCF s57 sa232 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Serine45 Beta Catenin s206 sa112 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s206 sa112 rs1 Serine45
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

uniprot Q09488 1078
type: UnificationXref
id: Q09488
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot E9HGM4 1795
organism: 6669

Protocadherin 19
type: ProteinReference
xref: PTHR24028:SF40
xref: uniprot A0A0G2K8I5 621
organism: Rattus norvegicus

Myc proto-oncogene protein
type: DnaReference
xref: PTHR45851:SF1
organism: 9031

uniprot Q02111 1693
type: UnificationXref
id: Q02111
db: uniprot

uniprot P63214 1969
type: UnificationXref
id: P63214
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR46029:SF3
xref: uniprot F6W5N2 604
organism: Monodelphis domestica

uniprot Q9NPG1 144
type: UnificationXref
id: Q9NPG1
db: uniprot

uniprot A0A2I3S7X1 1032
type: UnificationXref
id: A0A2I3S7X1
db: uniprot

uniprot Q5DRF0 866
type: UnificationXref
id: Q5DRF0
db: uniprot

Glycogen Synthase Kinase 3Beta s118 sa90 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glycogen Synthase Kinase 3Beta s118 sa90
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot K7E376 1957
organism: Monodelphis domestica

uniprot E1BWA3 1652
type: UnificationXref
id: E1BWA3
db: uniprot

uniprot F6UHL5 1567
type: UnificationXref
id: F6UHL5
db: uniprot

uniprot Q8RWY3 419
type: UnificationXref
id: Q8RWY3
db: uniprot

uniprot F7H3B3 1665
type: UnificationXref
id: F7H3B3
db: uniprot

uniprot E1C7M7 2013
type: UnificationXref
id: E1C7M7
db: uniprot

uniprot H2Q8F2 1667
type: UnificationXref
id: H2Q8F2
db: uniprot

Catenin alpha-2
type: ProteinReference
xref: PTHR18914:SF23
xref: uniprot P30997 2029
organism: 9031

MAP3K7 C-terminal-like protein
type: ProteinReference
xref: uniprot P58500 1073
organism: Mus musculus

uniprot F7AIP6 509
type: UnificationXref
id: F7AIP6
db: uniprot

uniprot Q9H158 936
type: UnificationXref
id: Q9H158
db: uniprot

Shaggy-related protein kinase delta
type: ProteinReference
xref: uniprot Q9FVS6 1026
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF84
xref: uniprot F7FZG1 764
organism: Macaca mulatta

Protocadherin-19 isoform c
type: ProteinReference
xref: uniprot F6USP1 726
xref: PTHR24028:SF40
organism: Macaca mulatta

CDH1 isoform 1
type: ProteinReference
xref: uniprot A0A2J8Q404 651
xref: PTHR24027:SF319
organism: Pan troglodytes

Uncharacterized protein
type: DnaReference
xref: PTHR10373:SF25
organism: Macaca mulatta

Dishevelled s2 sa230 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.8230462015585855
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot A0A1D5PQ72 625
type: UnificationXref
id: A0A1D5PQ72
db: uniprot

uniprot A8Y4R8 530
type: UnificationXref
id: A8Y4R8
db: uniprot

PARTICIPANT STOICHIOMETRY r69 2427
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 2428
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 2429
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

Myosin heavy chain 7B
type: DnaReference
xref: PTHR45615:SF29
organism: Rattus norvegicus

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 1
type: ProteinReference
xref: uniprot Q802C8 412
xref: PTHR13844:SF1
organism: Danio rerio

NFAT
type: Protein
entity reference: NFAT PROTEIN
feature: NFAT s238 a498 rs1
feature: ACTIVE 50
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P17252 1682
organism: Homo sapiens

PTHR13808:SF30
type: RelationshipXref
id: PTHR13808:SF30
db: PANTHER Family
relationship type: By Homology

Serine45 Beta Catenin s76 sa40 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s76 sa40 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

CSNK1A1L isoform 1
type: ProteinReference
xref: PTHR11909:SF139
xref: uniprot H2REV2 1806
organism: Pan troglodytes

PTHR13808:SF34
type: RelationshipXref
id: PTHR13808:SF34
db: PANTHER Family
relationship type: By Homology

uniprot Q96LZ3 1368
type: UnificationXref
id: Q96LZ3
db: uniprot

ACTIVE 50
type: EntityFeature
comment: Active state

uniprot Q9NQB0 515
type: UnificationXref
id: Q9NQB0
db: uniprot

uniprot Q8BJL0 414
type: UnificationXref
id: Q8BJL0
db: uniprot

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
type: ProteinReference
xref: uniprot Q9Z0H3 451
xref: PTHR10019:SF5
organism: Mus musculus

uniprot G5EG05 1198
type: UnificationXref
id: G5EG05
db: uniprot

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Synechocystis

uniprot Q336R6 1764
type: UnificationXref
id: Q336R6
db: uniprot

serine33 Beta Catenin s117 sa89 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s117 sa89 rs3 serine33
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

PTHR13808:SF28
type: RelationshipXref
id: PTHR13808:SF28
db: PANTHER Family
relationship type: By Homology

PTHR13808:SF29
type: RelationshipXref
id: PTHR13808:SF29
db: PANTHER Family
relationship type: By Homology

Smad4 s109 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smad4
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot F7A659 95
organism: Monodelphis domestica

Calcineurin B-like protein 5
type: ProteinReference
xref: uniprot Q7FZF1 1364
xref: PTHR23056:SF108
organism: Arabidopsis thaliana

uniprot F1PIB1 1382
type: UnificationXref
id: F1PIB1
db: uniprot

Dapper
type: ProteinReference
xref: P01469
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Dapper Synonym: Synonym not specified Accession: P01469
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Dapper
member entity reference: Dishevelled-binding antagonist of beta-catenin 1
member entity reference: Q66KC9
member entity reference: Dapper homolog 1

Protocadherin-20
type: ProteinReference
xref: uniprot Q8N6Y1 895
xref: PTHR24028:SF260
organism: Homo sapiens

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot Q336R6 1764
xref: PTHR11740:SF5
organism: Oryza sativa

Endothelin 1
type: DnaReference
xref: PTHR13874:SF10
organism: Danio rerio

Naked
type: Protein
entity reference: Naked PROTEIN
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot F7HKD3 1195
organism: Macaca mulatta

Arrestin beta 1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot F1PQM2 1566
organism: Canis lupus familiaris

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 1348

uniprot Q10452 1024
type: UnificationXref
id: Q10452
db: uniprot

ATP-dependent helicase brm
type: ProteinReference
xref: uniprot P25439 355
xref: PTHR10799:SF854
organism: Drosophila melanogaster

PTHR13808:SF43
type: RelationshipXref
id: PTHR13808:SF43
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
type: ProteinReference
xref: uniprot P25455 1112
xref: PTHR10336:SF149
organism: Drosophila melanogaster

Complex (G_Beta/Ggamma/ Galpha)
type: Complex
component stoichiometry: Ggamma s162 sa78 STOICHIOMETRY ID COMPLEX
component stoichiometry: Galpha s163 sa79 STOICHIOMETRY ID COMPLEX
component stoichiometry: GBeta s161 sa77 STOICHIOMETRY ID COMPLEX
component: GBeta s161 sa77
component: Galpha
component: Ggamma
feature: COMPLEX BINDING FEATURE s212 a473 2349
feature: COMPLEX BINDING FEATURE s212 a473 2345
feature: COMPLEX BINDING FEATURE s212 a473 2347
cellular location: plasma membrane

uniprot E2QWV0 278
type: UnificationXref
id: E2QWV0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VTH1 603
xref: PTHR46029:SF2
organism: Monodelphis domestica

Siah 1 s77 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Siah-1
stoichiometric coefficient: 1.0

Dishevelled s23 sa12 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.8230462015585855
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Protein dachsous
type: ProteinReference
xref: PTHR24026:SF100
xref: uniprot Q24292 849
organism: Drosophila melanogaster

DE-cadherin
type: ProteinReference
xref: PTHR24026:SF108
xref: uniprot Q24298 850
organism: Drosophila melanogaster

uniprot H2QD74 106
type: UnificationXref
id: H2QD74
db: uniprot

Serine45 Beta Catenin s128 sa114 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s128 sa114 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

uniprot F7G7I9 1946
type: UnificationXref
id: F7G7I9
db: uniprot

uniprot Q8N752 1853
type: UnificationXref
id: Q8N752
db: uniprot

uniprot F7A818 25
type: UnificationXref
id: F7A818
db: uniprot

Secreted frizzled-related protein 4
type: ProteinReference
xref: uniprot K7CC23 1884
xref: PTHR11309:SF7
organism: Pan troglodytes

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Drosophila melanogaster

Adenomatous Polyposis Coli
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa26 2274
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protocadherin 18
type: ProteinReference
xref: uniprot F1PD90 713
xref: PTHR24028:SF9
organism: Canis lupus familiaris

uniprot Q21831 379
type: UnificationXref
id: Q21831
db: uniprot

uniprot Q656Y0 1841
type: UnificationXref
id: Q656Y0
db: uniprot

uniprot Q5BIN2 388
type: UnificationXref
id: Q5BIN2
db: uniprot

uniprot P27467 1232
type: UnificationXref
id: P27467
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 3

Frizzled class receptor 4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot F6V5F4 93
organism: Xenopus tropicalis

Calcineurin subunit B type 2
type: ProteinReference
xref: PTHR45942:SF2
xref: uniprot P28470 1328
organism: Rattus norvegicus

uniprot E2RA74 1039
type: UnificationXref
id: E2RA74
db: uniprot

Serine45 Beta Catenin s232 a380 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s232 a380 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

uniprot Q7PV65 183
type: UnificationXref
id: Q7PV65
db: uniprot

uniprot Q9VDY1 446
type: UnificationXref
id: Q9VDY1
db: uniprot

uniprot Q28024 1975
type: UnificationXref
id: Q28024
db: uniprot

CDH12 isoform 1
type: ProteinReference
xref: uniprot A0A2J8KU53 647
xref: PTHR24027:SF96
organism: Pan troglodytes

Dishevelled s146 sa131 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dishevelled
stoichiometric coefficient: 1.0

T-box transcription factor T
type: DnaReference
xref: PTHR11267:SF83
organism: Homo sapiens

uniprot G3V8Y0 1950
type: UnificationXref
id: G3V8Y0
db: uniprot

NAFT Target Genes
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Frizzled-3
type: ProteinReference
xref: uniprot O77438 117
xref: PTHR11309:SF99
organism: Drosophila melanogaster

Transducin like enhancer of split 1
type: ProteinReference
xref: uniprot A0A3Q1M3K5 460
xref: PTHR10814:SF29
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot Q01970 1115
organism: Homo sapiens

uniprot F7HNU9 1500
type: UnificationXref
id: F7HNU9
db: uniprot

PTHR11909:SF409
type: RelationshipXref
id: PTHR11909:SF409
db: PANTHER Family
relationship type: By Homology

uniprot F1MC84 702
type: UnificationXref
id: F1MC84
db: uniprot

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot Q1JQA2 1552
organism: Bos taurus

uniprot F6R2T7 1798
type: UnificationXref
id: F6R2T7
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Dishevelled-RIGHT__Dishevelled-_re64
control type: INHIBITION
controller: Naked

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UDC8 724
xref: PTHR24027:SF272
organism: Macaca mulatta

PTHR11909:SF406
type: RelationshipXref
id: PTHR11909:SF406
db: PANTHER Family
relationship type: By Homology

AT15039p
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot Q7JWT4 1844
organism: Drosophila melanogaster

uniprot E2R263 1495
type: UnificationXref
id: E2R263
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF73
xref: uniprot A0A1D5R803 1129
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q2U4M7 1419
xref: PTHR24055:SF380
organism: 9031

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s133 sa118 2214
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot H9FU38 31
type: UnificationXref
id: H9FU38
db: uniprot

uniprot G3V8K2 1949
type: UnificationXref
id: G3V8K2
db: uniprot

uniprot F6TQN3 1099
type: UnificationXref
id: F6TQN3
db: uniprot

Axin s122 sa91 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

uniprot E2RJN9 685
type: UnificationXref
id: E2RJN9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24026:SF49
xref: uniprot F1MC84 702
organism: Bos taurus

Protocadherin beta 3
type: ProteinReference
xref: PTHR24028:SF118
xref: uniprot G3V8P1 781
organism: Rattus norvegicus

Cadherin EGF LAG seven-pass G-type receptor 2
type: ProteinReference
xref: PTHR24026:SF32
xref: uniprot G3V8P3 782
organism: Rattus norvegicus

AGAP006732-PA
type: ProteinReference
xref: PTHR24026:SF108
xref: uniprot Q7PT75 880
organism: Anopheles gambiae

Chromatin-remodeling ATPase INO80
type: ProteinReference
xref: PTHR45685:SF2
xref: uniprot Q9VDY1 446
organism: Drosophila melanogaster

uniprot A8WV10 1139
type: UnificationXref
id: A8WV10
db: uniprot

Ebi s78 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ebi
stoichiometric coefficient: 1.0

Frizzled-7
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot Q5BL72 124
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r93 2467
type: Stoichiometry
physical entity: a561_degraded
stoichiometric coefficient: 1.0

uniprot H2QJF8 1204
type: UnificationXref
id: H2QJF8
db: uniprot

PARTICIPANT STOICHIOMETRY r93 2466
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

uniprot D4ADD1 669
type: UnificationXref
id: D4ADD1
db: uniprot

Homeobox protein engrailed-like
type: DnaReference
xref: PTHR24341:SF4
organism: Danio rerio

Calcineurin
type: Protein
entity reference: Calcineurin
feature: ACTIVE 50
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

STATE TRANSITION LEFT Ubiquitin- Complex Adenomatous Polyposis Coli Axin PP2A Diversin Casein Kinase 1 Beta Catenin betaTrCP Glycogen Synthase Kinase 3Beta -RIGHT Complex Adenomatous Polyposis Coli Axin PP2A Diversin Casein Kinase 1 Beta Catenin betaTrCP Glycogen Synthase Kinase 3Beta - r90
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 2479
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 2478
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 2477
left: Complex (Adenomatous Polyposis Coli/Axin/ PP2A/Diversin/ Casein Kinase 1/Beta-Catenin/ betaTrCP/Glycogen Synthase Kinase-3Beta)
left: Ubiquitin s268 a558
display name: STATE_TRANSITION_LEFT__Ubiquitin-_Complex__Adenomatous_Polyposis_Coli_Axin__PP2A_Diversin__Casein_Kinase_1_Beta_Catenin__betaTrCP_Glycogen_Synthase_Kinase_3Beta_-RIGHT__Complex__Adenomatous_Polyposis_Coli_Axin__PP2A_Diversin__Casein_Kinase_1_Beta_Catenin__betaTrCP_Glycogen_Synthase_Kinase_3Beta_-_r90
interaction type: STATE_TRANSITION
right: Complex (Adenomatous Polyposis Coli/Axin/ PP2A/Diversin/ Casein Kinase 1/Beta-Catenin/ betaTrCP/Glycogen Synthase Kinase-3Beta)

uniprot Q9WTQ0 1707
type: UnificationXref
id: Q9WTQ0
db: uniprot

PTHR23056:SF116
type: RelationshipXref
id: PTHR23056:SF116
db: PANTHER Family
relationship type: By Homology

uniprot H2QDN6 324
type: UnificationXref
id: H2QDN6
db: uniprot

TCF s167 a383 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GYL6 1307
xref: PTHR45942:SF1
organism: 6669

TP53
type: Protein
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein Wnt-1
type: ProteinReference
xref: uniprot P24257 1230
xref: PTHR12027:SF91
organism: Danio rerio

PTHR23056:SF110
type: RelationshipXref
id: PTHR23056:SF110
db: PANTHER Family
relationship type: By Homology

uniprot Q9UN67 956
type: UnificationXref
id: Q9UN67
db: uniprot

PARTICIPANT STOICHIOMETRY r58 2497
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 2498
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

Calcineurin
type: Protein
entity reference: Calcineurin
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot P97633 1832
organism: Rattus norvegicus

uniprot F6W548 1935
type: UnificationXref
id: F6W548
db: uniprot

PTHR23056:SF106
type: RelationshipXref
id: PTHR23056:SF106
db: PANTHER Family
relationship type: By Homology

Glycogen Synthase Kinase-3Beta
type: Protein
entity reference: Glycogen Synthase Kinase 3 Beta PROTEIN
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot J9P148 337
type: UnificationXref
id: J9P148
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot F7D1A1 1185
organism: Xenopus tropicalis

uniprot Q9CAI5 1862
type: UnificationXref
id: Q9CAI5
db: uniprot

PTHR23056:SF108
type: RelationshipXref
id: PTHR23056:SF108
db: PANTHER Family
relationship type: By Homology

PTHR23056:SF109
type: RelationshipXref
id: PTHR23056:SF109
db: PANTHER Family
relationship type: By Homology

uniprot Q9N0H5 1593
type: UnificationXref
id: Q9N0H5
db: uniprot

serine33 Beta Catenin s206 sa112 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s206 sa112 rs3 serine33
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

Frizzled-2
type: ProteinReference
xref: PTHR11309:SF126
xref: uniprot Q9VVX3 151
organism: Drosophila melanogaster

uniprot P63213 1968
type: UnificationXref
id: P63213
db: uniprot

uniprot F1NG47 1658
type: UnificationXref
id: F1NG47
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A2I3SSC7 5
organism: Pan troglodytes

Pygopus homolog 1
type: ProteinReference
xref: uniprot Q9D0P5 1915
xref: PTHR23194:SF3
organism: Mus musculus

Cadherin-2
type: ProteinReference
xref: PTHR24027:SF79
xref: uniprot P19534 818
organism: Bos taurus

uniprot O14640 1388
type: UnificationXref
id: O14640
db: uniprot

Cadherin-11
type: ProteinReference
xref: PTHR24027:SF85
xref: uniprot P55288 832
organism: Mus musculus

Cadherin-11
type: ProteinReference
xref: uniprot P55287 831
xref: PTHR24027:SF85
organism: Homo sapiens

Cadherin-8
type: ProteinReference
xref: PTHR24027:SF273
xref: uniprot P55286 830
organism: Homo sapiens

Cadherin-6
type: ProteinReference
xref: PTHR24027:SF322
xref: uniprot P55285 829
organism: Homo sapiens

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF192
xref: uniprot Q6ZB59 2088
organism: Oryza sativa

uniprot Q9V3Q6 1087
type: UnificationXref
id: Q9V3Q6
db: uniprot

uniprot Q5DRE0 865
type: UnificationXref
id: Q5DRE0
db: uniprot

Cadherin-12
type: ProteinReference
xref: uniprot P55289 833
xref: PTHR24027:SF96
organism: Homo sapiens

Cadherin-6
type: ProteinReference
xref: uniprot P55280 825
xref: PTHR24027:SF322
organism: Rattus norvegicus

Cadherin-5
type: ProteinReference
xref: uniprot P55284 828
xref: PTHR24027:SF89
organism: Mus musculus

Cadherin-4
type: ProteinReference
xref: uniprot P55283 827
xref: PTHR24027:SF81
organism: Homo sapiens

Cadherin-17
type: ProteinReference
xref: PTHR24027:SF419
xref: uniprot P55281 826
organism: Rattus norvegicus

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q62074 1702
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot Q62073 1082
organism: Mus musculus

uniprot F7H808 557
type: UnificationXref
id: F7H808
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q9JID2 1468
organism: Rattus norvegicus

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot Q7Q5D2 2094
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: PTHR45685:SF2
xref: uniprot A0A3Q1N8M5 261
organism: Bos taurus

uniprot Q66II0 1266
type: UnificationXref
id: Q66II0
db: uniprot

Catenin beta-1
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot F7GNE4 190
organism: Macaca mulatta

uniprot Q9R1V3 1558
type: UnificationXref
id: Q9R1V3
db: uniprot

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot F6T6M8 1729
xref: PTHR11740:SF0
organism: Monodelphis domestica

Beta Arrestin s24 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta Arrestin s24 sa13
stoichiometric coefficient: 1.0

Cadherin-15
type: ProteinReference
xref: uniprot P55291 835
xref: PTHR24027:SF300
organism: Homo sapiens

Cadherin-13
type: ProteinReference
xref: PTHR24027:SF80
xref: uniprot P55290 834
organism: Homo sapiens

uniprot O60245 805
type: UnificationXref
id: O60245
db: uniprot

eco ECO:0000270 1088
type: UnificationXref
id: ECO:0000270
db: eco

Protein naked cuticle
type: ProteinReference
xref: PTHR22611:SF9
xref: uniprot Q9VVV9 62
organism: Drosophila melanogaster

Fat-like cadherin-related tumor suppressor homolog
type: ProteinReference
xref: uniprot Q9VW71 968
xref: PTHR24026:SF101
organism: Drosophila melanogaster

Secreted frizzled-related protein 4
type: ProteinReference
xref: PTHR11309:SF7
xref: uniprot Q6FHJ7 1888
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__Wnt-_Frizzled-RIGHT__Complex__Wnt_Frizzled_-_r1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 2411
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 2412
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 2410
left: Wnt
left: Frizzled
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Wnt/Frizzled)

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A1D5Q6M6 523
xref: PTHR10257:SF6
organism: Macaca mulatta

uniprot E1BQ10 676
type: UnificationXref
id: E1BQ10
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F6XL57 551
xref: PTHR10257:SF6
organism: 9258

AT-rich interaction domain 1B
type: ProteinReference
xref: uniprot A0A2I3SSA4 254
xref: PTHR12656:SF11
organism: Pan troglodytes

ncbitaxon 6945 535
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot Q08DJ5 843
type: UnificationXref
id: Q08DJ5
db: uniprot

Cyclin D1
type: DnaReference
xref: PTHR10177:SF67
organism: Bos taurus

uniprot O64817 1738
type: UnificationXref
id: O64817
db: uniprot

Frizzled class receptor 5
type: ProteinReference
xref: uniprot F6QAW3 87
xref: PTHR11309:SF141
organism: Xenopus tropicalis

uniprot P38408 1460
type: UnificationXref
id: P38408
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24028:SF119
xref: uniprot F7GRQ8 769
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Complex__Dishevelled_Beta_Arrestin__Frodo_-_ATP-RIGHT__ADP-_Complex__Dishevelled_Beta_Arrestin__Frodo_-_r104
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 2493
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 2496
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 2495
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 2494
left: ATP
left: Complex Dishevelled Beta Arrestin Frodo s107 a224
interaction type: STATE_TRANSITION
right: Complex (Dishevelled/Beta-Arrestin/ Frodo)
right: ADP

SMARCD1 isoform 1
type: ProteinReference
xref: uniprot A0A2I3S359 252
xref: PTHR13844:SF1
organism: Pan troglodytes

uniprot Q147F4 378
type: UnificationXref
id: Q147F4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24028:SF12
xref: uniprot F7GRQ5 768
organism: Macaca mulatta

B-cell CLL/lymphoma 9
type: ProteinReference
xref: PTHR15185:SF5
xref: uniprot H2PZV0 1436
organism: Pan troglodytes

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot K7CBH8 1671
xref: PTHR24356:SF159
organism: Pan troglodytes

uniprot F7E5M4 554
type: UnificationXref
id: F7E5M4
db: uniprot

Casein kinase I homolog 3
type: ProteinReference
xref: PTHR11909:SF374
xref: uniprot P39962 1819
organism: Saccharomyces cerevisiae

uniprot H2Q5G9 179
type: UnificationXref
id: H2Q5G9
db: uniprot

Ebi
type: Protein
entity reference: Ebi
feature: COMPLEX PARTICIPANT BINDING FEATURE s131 sa116 2210
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein mothers against dpp
type: ProteinReference
xref: PTHR13703:SF61
xref: uniprot P42003 1545
organism: Drosophila melanogaster

Cadherin 3
type: ProteinReference
xref: uniprot F6QAX3 719
xref: PTHR24027:SF267
organism: Xenopus tropicalis

NFAT Target Genes
type: DnaRegion
entity reference: NFAT Target Genes
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Uncharacterized protein
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot A0A2I3S2S2 456
organism: Pan troglodytes

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F1MBM6 202
organism: Bos taurus

Nuclear factor of activated T cells 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot F1PDD9 1477
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF151
xref: uniprot F7H415 1805
organism: Macaca mulatta

Casein Kinase 2
type: Protein
entity reference: Casein Kinase 2
feature: COMPLEX PARTICIPANT BINDING FEATURE s149 sa134 2300
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P63330 570
type: UnificationXref
id: P63330
db: uniprot

uniprot Q9EQH5 617
type: UnificationXref
id: Q9EQH5
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot A3KGF7 1093
xref: PTHR10336:SF10
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r59 2489
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 2488
type: Stoichiometry
physical entity: Smad4
stoichiometric coefficient: 1.0

F-box-like/WD repeat-containing protein ebi
type: ProteinReference
xref: uniprot Q95RJ9 1506
xref: PTHR22846:SF2
organism: Drosophila melanogaster

uniprot Q9H251 938
type: UnificationXref
id: Q9H251
db: uniprot

uniprot P08181 1743
type: UnificationXref
id: P08181
db: uniprot

uniprot E7FC99 186
type: UnificationXref
id: E7FC99
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QHP7 1560
xref: PTHR11792:SF19
organism: Macaca mulatta

G protein subunit gamma 13
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot G3V8Y0 1950
organism: Rattus norvegicus

sFRP
type: Protein
entity reference: sFRP
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: DnaReference
xref: PTHR11267:SF83
organism: Bos taurus

Protocadherin beta-16-like
type: ProteinReference
xref: uniprot G3V987 783
xref: PTHR24028:SF71
organism: Rattus norvegicus

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot P70340 1546
organism: Mus musculus

uniprot F1P714 543
type: UnificationXref
id: F1P714
db: uniprot

uniprot Q6FHJ7 1888
type: UnificationXref
id: Q6FHJ7
db: uniprot

DISSOCIATION_LEFT__PI_4,5_P2-RIGHT__DAG-_IP3-_r110
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r110 2454
participant stoichiometry: PARTICIPANT STOICHIOMETRY r110 2456
participant stoichiometry: PARTICIPANT STOICHIOMETRY r110 2455
left: PI(4,5)P2
interaction type: DISSOCIATION
right: DAG
right: IP3

Protein kinase C eta type
type: ProteinReference
xref: uniprot F1MY82 1657
xref: PTHR24356:SF192
organism: Bos taurus

uniprot F7BYI4 1663
type: UnificationXref
id: F7BYI4
db: uniprot

Activin receptor type-1C
type: ProteinReference
xref: uniprot Q8NER5 1086
organism: Homo sapiens

uniprot F6Y042 309
type: UnificationXref
id: F6Y042
db: uniprot

PTHR13809:SF5
type: RelationshipXref
id: PTHR13809:SF5
db: PANTHER Family
relationship type: By Homology

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: 69014

Secreted frizzled-related protein 3
type: ProteinReference
xref: uniprot F7BWZ1 1882
xref: PTHR11309:SF97
organism: Macaca mulatta

Adenylosuccinate synthetase isozyme 2
type: DnaReference
xref: PTHR11846:SF13
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re64 2504
type: Stoichiometry
physical entity: Dishevelled
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re64 2505
type: Stoichiometry
physical entity: Dishevelled
stoichiometric coefficient: 1.0

uniprot G3V8P3 782
type: UnificationXref
id: G3V8P3
db: uniprot

ncbitaxon 9615 16
type: UnificationXref
id: 9615
db: ncbitaxon

Serine35 Beta Catenin s88 sa58 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s88 sa58 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

uniprot Q91Y03 922
type: UnificationXref
id: Q91Y03
db: uniprot

Beta Catenin s128 sa114 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

ncbitaxon 243230 443
type: UnificationXref
id: 243230
db: ncbitaxon

uniprot H2QKP9 790
type: UnificationXref
id: H2QKP9
db: uniprot

Protein Wnt-5
type: ProteinReference
xref: PTHR12027:SF77
xref: uniprot P28466 1235
organism: Drosophila melanogaster

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF112
xref: uniprot P28465 1234
organism: Drosophila melanogaster

uniprot B1WC68 2048
type: UnificationXref
id: B1WC68
db: uniprot

Calcineurin B-like protein 3
type: ProteinReference
xref: uniprot Q75LU8 1362
xref: PTHR23056:SF90
organism: Oryza sativa

uniprot J9P5H0 1210
type: UnificationXref
id: J9P5H0
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6U7A6 547
xref: PTHR45619:SF42
organism: Monodelphis domestica

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6ZKL2 1101
xref: PTHR10336:SF12
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r107 2487
type: Stoichiometry
physical entity: Wnt
stoichiometric coefficient: 1.0

Axin s136 sa121 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin s136 sa121
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r107 2486
type: Stoichiometry
physical entity: Wnt
stoichiometric coefficient: 1.0

uniprot F1N1S8 541
type: UnificationXref
id: F1N1S8
db: uniprot

Serine/threonine-protein phosphatase 2B catalytic subunit 2
type: ProteinReference
xref: PTHR45673:SF1
xref: uniprot Q27889 1351
organism: Drosophila melanogaster

Transducin like enhancer of split 4
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot F1N9Y3 465
organism: 9031

Abnormal cell lineage protein 44
type: ProteinReference
xref: PTHR12027:SF112
xref: uniprot Q27886 1256
organism: Caenorhabditis elegans

NKD1 isoform 1
type: ProteinReference
xref: uniprot H2RA69 57
xref: PTHR22611:SF2
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 1925
xref: PTHR13809:SF5
organism: Canis lupus familiaris

Adenomatous Polyposis Coli
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa22 2144
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r59 2490
type: Stoichiometry
physical entity: Complex (TCF/Smad4)
stoichiometric coefficient: 1.0

TCF s79 sa50 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCF s79 sa50
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q567Y8 583
xref: PTHR45619:SF42
organism: Danio rerio

Tau TuBulin Kinase
type: ProteinReference
xref: uniprot Q22033 1834
xref: PTHR11909:SF297
organism: Caenorhabditis elegans

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot A4IIN1 200
organism: Xenopus tropicalis

Casein kinase II subunit alpha 3
type: ProteinReference
xref: uniprot Q8NEV1 1777
xref: PTHR24054:SF16
organism: Homo sapiens

uniprot F6XUZ7 1183
type: UnificationXref
id: F6XUZ7
db: uniprot

Beta Catenin s100 sa70 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Methanocaldococcus jannaschii

Predicted protein
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot A7RPJ6 1791
organism: 45351

AGAP006475-PA
type: ProteinReference
xref: uniprot Q5TQX0 44
xref: PTHR13715:SF87
organism: Anopheles gambiae

uniprot Q9Y5G8 991
type: UnificationXref
id: Q9Y5G8
db: uniprot

Beta Catenin s82 sa52 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot P17343 1619
organism: Caenorhabditis elegans

SMARCC1 isoform 2
type: ProteinReference
xref: PTHR12802:SF9
xref: uniprot H2QMI4 325
organism: Pan troglodytes

uniprot Q9Y5E6 974
type: UnificationXref
id: Q9Y5E6
db: uniprot

Pygopus family PHD finger 1
type: ProteinReference
xref: PTHR23194:SF3
xref: uniprot F1MHP8 1908
organism: Bos taurus

Protein Wnt
type: ProteinReference
xref: uniprot B1WBR9 1143
xref: PTHR12027:SF87
organism: Rattus norvegicus

uniprot F7DVL1 1664
type: UnificationXref
id: F7DVL1
db: uniprot

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s190 sa105 2128
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6SD46 1098
xref: PTHR10336:SF12
organism: Monodelphis domestica

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F6SV50 1049
organism: Monodelphis domestica

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F6WEY4 204
xref: PTHR45877:SF1
organism: Macaca mulatta

Serine45 Beta Catenin s36 a37 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s36 a37 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

Dishevelled
type: Protein
entity reference: Dishevelled
feature: ACTIVE 50
feature: Dishevelled s2 sa230 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Homeobox protein invected
type: DnaReference
xref: PTHR24341:SF6
organism: Drosophila melanogaster

uniprot Q14573 42
type: UnificationXref
id: Q14573
db: uniprot

uniprot D4A9D7 1157
type: UnificationXref
id: D4A9D7
db: uniprot

uniprot Q924A0 513
type: UnificationXref
id: Q924A0
db: uniprot

Protein CBR-SWSN-2.1
type: ProteinReference
xref: PTHR13844:SF7
xref: uniprot A8X9V3 269
organism: Caenorhabditis briggsae

PTHR24055:SF484
type: RelationshipXref
id: PTHR24055:SF484
db: PANTHER Family
relationship type: By Homology

uniprot A5PKD6 1597
type: UnificationXref
id: A5PKD6
db: uniprot

Phospholipase C
type: Protein
entity reference: Phospholipase C
feature: COMPLEX PARTICIPANT BINDING FEATURE s157 sa76 2158
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Myosin-7B
type: DnaReference
xref: PTHR45615:SF29
organism: Homo sapiens

uniprot H2QRN6 2063
type: UnificationXref
id: H2QRN6
db: uniprot

Protocadherin-19
type: ProteinReference
xref: uniprot Q8TAB3 899
xref: PTHR24028:SF40
organism: Homo sapiens

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-A
type: ProteinReference
xref: uniprot Q5U379 389
xref: PTHR10019:SF5
organism: Danio rerio

uniprot F0Z8A7 1725
type: UnificationXref
id: F0Z8A7
db: uniprot

Catenin alpha-3
type: ProteinReference
xref: PTHR18914:SF21
xref: uniprot Q65CL1 2036
organism: Mus musculus

Activin receptor type-1C
type: ProteinReference
xref: uniprot Q8K348 1085
organism: Mus musculus

Smad4
type: Protein
entity reference: Smad4
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa233 2252
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: DnaReference
xref: PTHR11267:SF106
organism: 7739

uniprot F7CQY4 312
type: UnificationXref
id: F7CQY4
db: uniprot

Beta Catenin s92 sa62 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

Frizzled-6
type: ProteinReference
xref: uniprot O60353 114
xref: PTHR11309:SF75
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r35 2434
type: Stoichiometry
physical entity: Frodo s103 a212
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 2435
type: Stoichiometry
physical entity: Complex Beta Arrestin Dishevelled s108 a227
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 2436
type: Stoichiometry
physical entity: Complex Dishevelled Beta Arrestin Frodo s107 a224
stoichiometric coefficient: 1.0

uniprot P26231 2027
type: UnificationXref
id: P26231
db: uniprot

PTHR13809:SF6
type: RelationshipXref
id: PTHR13809:SF6
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1LYG2 655
type: UnificationXref
id: A0A3Q1LYG2
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot E2RGU7 1653
organism: Canis lupus familiaris

PTHR13809:SF9
type: RelationshipXref
id: PTHR13809:SF9
db: PANTHER Family
relationship type: By Homology

PTHR13809:SF8
type: RelationshipXref
id: PTHR13809:SF8
db: PANTHER Family
relationship type: By Homology

uniprot F6THW2 1444
type: UnificationXref
id: F6THW2
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot E2R3R6 1038
organism: Canis lupus familiaris

Histone deacetylase 8
type: ProteinReference
xref: uniprot B1WC68 2048
xref: PTHR10625:SF109
organism: Rattus norvegicus

Snf2 related CREBBP activator protein
type: ProteinReference
xref: uniprot A0A2I3SBF9 253
xref: PTHR45685:SF1
organism: Pan troglodytes

uniprot J9P2Q5 1209
type: UnificationXref
id: J9P2Q5
db: uniprot

GTP
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Putative casein kinase II subunit beta-4
type: ProteinReference
xref: PTHR11740:SF30
xref: uniprot O80507 1739
organism: Arabidopsis thaliana

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot F6R543 19
xref: PTHR13715:SF51
organism: Monodelphis domestica

uniprot F7E427 1612
type: UnificationXref
id: F7E427
db: uniprot

Frizzled-2
type: ProteinReference
xref: uniprot Q9JIP6 142
xref: PTHR11309:SF34
organism: Mus musculus

uniprot A7E4J2 1301
type: UnificationXref
id: A7E4J2
db: uniprot

Histone deacetylase 2
type: ProteinReference
xref: PTHR10625:SF203
xref: uniprot P70288 2078
organism: Mus musculus

uniprot O35625 161
type: UnificationXref
id: O35625
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NFAT-RIGHT__NFAT-_Pi-_r80
controller: Calcineurin

uniprot A0A286YBG8 1562
type: UnificationXref
id: A0A286YBG8
db: uniprot

Inositol 1,4,5-trisphosphate receptor itr-1
type: ProteinReference
xref: PTHR13715:SF87
xref: uniprot Q9Y0A1 47
organism: Caenorhabditis elegans

uniprot B5DEH9 1991
type: UnificationXref
id: B5DEH9
db: uniprot

uniprot P33450 822
type: UnificationXref
id: P33450
db: uniprot

Casein kinase II subunit alpha-4, chloroplastic
type: ProteinReference
xref: uniprot O64816 1737
xref: PTHR24054:SF43
organism: Arabidopsis thaliana

Casein kinase II subunit alpha-3
type: ProteinReference
xref: uniprot O64817 1738
xref: PTHR24054:SF47
organism: Arabidopsis thaliana

Frizzled-6
type: ProteinReference
xref: PTHR11309:SF75
xref: uniprot F6SV99 92
organism: Macaca mulatta

uniprot H2QRH7 561
type: UnificationXref
id: H2QRH7
db: uniprot

uniprot Q13469 1485
type: UnificationXref
id: Q13469
db: uniprot

uniprot Q9CXP8 1983
type: UnificationXref
id: Q9CXP8
db: uniprot

Secreted frizzled-related protein 2
type: ProteinReference
xref: PTHR11309:SF45
xref: uniprot B1WBV2 226
organism: Rattus norvegicus

uniprot Q9H808 495
type: UnificationXref
id: Q9H808
db: uniprot

uniprot J9NUI0 2064
type: UnificationXref
id: J9NUI0
db: uniprot

Protocadherin gamma-A12
type: ProteinReference
xref: uniprot O60330 806
xref: PTHR24028:SF227
organism: Homo sapiens

Threonine41 Beta Catenin s206 sa112 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s206 sa112 rs4 Threonine41
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

Frizzled
type: ProteinReference
xref: P01428
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.RECEPTOR.Frizzled
comment: ENTITY_REFERENCE_NOTES= Long Name: Frizzled Synonym: Synonym not specified Accession: P01428
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Frizzled-2
member entity reference: Frizzled-3
member entity reference: Frizzled class receptor 9b
member entity reference: Frizzled-8
member entity reference: Frizzled class receptor 5
member entity reference: Frizzled-10
member entity reference: Frizzled-4
member entity reference: Q13467
member entity reference: Frizzled-7
member entity reference: Frizzled class receptor 3
member entity reference: Frizzled class receptor 7
member entity reference: Frizzled class receptor 4
member entity reference: Frizzled-5
member entity reference: Frizzled-9
member entity reference: F6RKF7
member entity reference: Frizzled class receptor 6
member entity reference: FZD10 isoform 2
member entity reference: Frizzled class receptor 10
member entity reference: Frizzled class receptor 8b
member entity reference: AGAP008871-PA (Fragment)
member entity reference: Frizzled class receptor 2
member entity reference: FZD3 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Frizzled class receptor 7a
member entity reference: Frizzled-1
member entity reference: Frizzled-6
member entity reference: Frizzled 7a
member entity reference: Frizzled
member entity reference: Q8BKG4
member entity reference: F7DIA9
member entity reference: Transmembrane receptor LIN-17
member entity reference: FZD10 protein
member entity reference: FZD1 protein
member entity reference: F7CDC6
member entity reference: Protein mom-5
member entity reference: Frizzled class receptor 8
member entity reference: H2QD74
member entity reference: Frizzled 8a protein
member entity reference: F6PWM3

Myosin heavy chain 13
type: DnaReference
xref: PTHR45615:SF44
organism: Bos taurus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot E1BKL2 1161
organism: Bos taurus

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
type: ProteinReference
xref: uniprot A0A3Q1M384 259
xref: PTHR10799:SF879
organism: Bos taurus

uniprot A0A2I3RSP9 1297
type: UnificationXref
id: A0A2I3RSP9
db: uniprot

ADP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ggamma
type: Protein
entity reference: G gamma PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s160 sa81 2142
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6ZW11 742
type: UnificationXref
id: F6ZW11
db: uniprot

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 1951
xref: PTHR13809:SF51
organism: Pan troglodytes

Cadherin 11
type: ProteinReference
xref: uniprot F6UDX0 725
xref: PTHR24027:SF85
organism: 9258

uniprot F1MGR9 1475
type: UnificationXref
id: F1MGR9
db: uniprot

uniprot Q9W6E0 1893
type: UnificationXref
id: Q9W6E0
db: uniprot

Protein serine/threonine kinase
type: ProteinReference
xref: uniprot F0Z8A7 1725
xref: PTHR24054:SF0
organism: Dictyostelium purpureum

Calcineurin B-like protein 10
type: ProteinReference
xref: PTHR23056:SF26
xref: uniprot Q7FRS8 1363
organism: Arabidopsis thaliana

Casein kinase 2 alpha 2
type: ProteinReference
xref: uniprot F6R511 1727
xref: PTHR24054:SF34
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR24026:SF108
xref: uniprot F1MXP9 707
organism: Bos taurus

uniprot D4A3W9 1156
type: UnificationXref
id: D4A3W9
db: uniprot

uniprot Q93Z18 1859
type: UnificationXref
id: Q93Z18
db: uniprot

Protein kinase C, eye isozyme
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P13677 1680
organism: Drosophila melanogaster

uniprot P43425 1960
type: UnificationXref
id: P43425
db: uniprot

uniprot F7ACT4 1015
type: UnificationXref
id: F7ACT4
db: uniprot

Cadherin-14
type: ProteinReference
xref: PTHR24027:SF106
xref: uniprot F7FMS7 763
organism: Macaca mulatta

uniprot H2QZN8 1954
type: UnificationXref
id: H2QZN8
db: uniprot

Kremen
type: Protein
entity reference: Kremen
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Beta Arrestin s147 sa132 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Arrestin
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot E1BKE7 14
xref: PTHR13715:SF51
organism: Bos taurus

uniprot Q27889 1351
type: UnificationXref
id: Q27889
db: uniprot

uniprot P56706 1252
type: UnificationXref
id: P56706
db: uniprot

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot F6WVD0 1731
xref: PTHR11740:SF0
organism: Xenopus tropicalis

uniprot A0A2I3SDT1 639
type: UnificationXref
id: A0A2I3SDT1
db: uniprot

uniprot P20651 1325
type: UnificationXref
id: P20651
db: uniprot

Catenin (Cadherin associated protein), alpha 1
type: ProteinReference
xref: uniprot Q5U302 2034
xref: PTHR18914:SF24
organism: Rattus norvegicus

Cadherin-13
type: ProteinReference
xref: uniprot Q3B7N0 851
xref: PTHR24027:SF80
organism: Bos taurus

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot A8WY01 2047
organism: Caenorhabditis briggsae

Chromodomain-helicase-DNA-binding protein 1-like
type: ProteinReference
xref: uniprot Q3B7N1 383
xref: PTHR47157:SF1
organism: Bos taurus

uniprot A0A1D5Q352 628
type: UnificationXref
id: A0A1D5Q352
db: uniprot

uniprot Q9FFH8 1864
type: UnificationXref
id: Q9FFH8
db: uniprot

uniprot Q7PX00 2093
type: UnificationXref
id: Q7PX00
db: uniprot

PARTICIPANT STOICHIOMETRY r104 2493
type: Stoichiometry
physical entity: Complex Dishevelled Beta Arrestin Frodo s107 a224
stoichiometric coefficient: 1.0

a561_degraded
type: PhysicalEntity
cellular location: plasma membrane
comment: SPECIES_TYPE=DEGRADED

PARTICIPANT STOICHIOMETRY r104 2494
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r104 2495
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Dishevelled-_Beta_Arrestin-RIGHT__Complex__Beta_Arrestin_Dishevelled_-_r34
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 2443
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 2444
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 2445
left: Dishevelled
left: Beta Arrestin s12 a12
interaction type: HETERODIMER_ASSOCIATION
right: Complex Beta Arrestin Dishevelled s108 a227

PARTICIPANT STOICHIOMETRY r104 2496
type: Stoichiometry
physical entity: Complex (Dishevelled/Beta-Arrestin/ Frodo)
stoichiometric coefficient: 1.0

uniprot Q8C4X2 1848
type: UnificationXref
id: Q8C4X2
db: uniprot

Serine35 Beta Catenin s100 sa70 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s100 sa70 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

uniprot F7D4J8 1186
type: UnificationXref
id: F7D4J8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MHH5 704
xref: PTHR24026:SF38
organism: Bos taurus

PTHR11309:SF81
type: RelationshipXref
id: PTHR11309:SF81
db: PANTHER Family
relationship type: By Homology

PTHR46459:SF1
type: RelationshipXref
id: PTHR46459:SF1
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF86
type: RelationshipXref
id: PTHR11309:SF86
db: PANTHER Family
relationship type: By Homology

uniprot F7ALE8 2018
type: UnificationXref
id: F7ALE8
db: uniprot

Cadherin-7
type: ProteinReference
xref: PTHR24027:SF91
xref: uniprot Q90763 906
organism: 9031

Cadherin-6
type: ProteinReference
xref: uniprot Q90762 905
xref: PTHR24027:SF322
organism: 9031

PTHR11309:SF87
type: RelationshipXref
id: PTHR11309:SF87
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Complex__Wnt_Frizzled_-_LRP5_6-RIGHT__Complex__Frizzled_Wnt__LRP5_6_-_r5
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 2393
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 2391
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 2392
left: LRP5/6
left: Complex (Wnt/Frizzled)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Frizzled/Wnt/ LRP5/6)

uniprot Q9YI00 153
type: UnificationXref
id: Q9YI00
db: uniprot

uniprot C3PTE8 1564
type: UnificationXref
id: C3PTE8
db: uniprot

Dishevelled s38 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dishevelled
stoichiometric coefficient: 1.0

Catenin alpha
type: ProteinReference
xref: uniprot P35220 2030
xref: PTHR18914:SF9
organism: Drosophila melanogaster

Protein Wnt
type: ProteinReference
xref: uniprot F1MHG3 1167
xref: PTHR12027:SF94
organism: Bos taurus

Serine/threonine-protein phosphatase 2B catalytic subunit A2
type: ProteinReference
xref: uniprot P14747 1323
xref: PTHR45673:SF1
organism: Saccharomyces cerevisiae

Catenin beta-1
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot P35222 193
organism: Homo sapiens

Smad4 s94 sa64 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smad4
stoichiometric coefficient: 1.0

Catenin alpha-1
type: ProteinReference
xref: PTHR18914:SF24
xref: uniprot P35221 2031
organism: Homo sapiens

PTHR11309:SF90
type: RelationshipXref
id: PTHR11309:SF90
db: PANTHER Family
relationship type: By Homology

uniprot F1LMH8 1519
type: UnificationXref
id: F1LMH8
db: uniprot

uniprot P49337 1244
type: UnificationXref
id: P49337
db: uniprot

PTHR11309:SF97
type: RelationshipXref
id: PTHR11309:SF97
db: PANTHER Family
relationship type: By Homology

Myosin heavy chain 6
type: DnaReference
xref: PTHR45615:SF11
organism: Bos taurus

PTHR11309:SF99
type: RelationshipXref
id: PTHR11309:SF99
db: PANTHER Family
relationship type: By Homology

uniprot F6RA79 1659
type: UnificationXref
id: F6RA79
db: uniprot

Secreted frizzled-related protein 4
type: ProteinReference
xref: uniprot Q17QP5 1886
xref: PTHR11309:SF7
organism: Bos taurus

uniprot Q63810 1357
type: UnificationXref
id: Q63810
db: uniprot

uniprot A0A2I3S2B9 251
type: UnificationXref
id: A0A2I3S2B9
db: uniprot

uniprot P87072 1342
type: UnificationXref
id: P87072
db: uniprot

uniprot Q28C95 491
type: UnificationXref
id: Q28C95
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot E2RH98 1164
organism: Canis lupus familiaris

PP2A s70 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V5K8 2054
xref: PTHR10625:SF201
organism: Macaca mulatta

uniprot F7A632 1661
type: UnificationXref
id: F7A632
db: uniprot

uniprot Q9NBW1 143
type: UnificationXref
id: Q9NBW1
db: uniprot

Beta Catenin s84 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta Catenin s84 sa54
stoichiometric coefficient: 1.0

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 1
type: ProteinReference
xref: PTHR12802:SF9
xref: uniprot A0A0G2K9D6 247
organism: Rattus norvegicus

uniprot A0A1D5QUK7 1031
type: UnificationXref
id: A0A1D5QUK7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q3B1W2 503
xref: PTHR10373:SF11
organism: 9031

Histone deacetylase
type: ProteinReference
xref: uniprot A0A1D5QWF8 2044
xref: PTHR10625:SF109
organism: Macaca mulatta

uniprot O88278 809
type: UnificationXref
id: O88278
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot A0A2I3RQJ8 1645
organism: Pan troglodytes

uniprot Q6C8U8 1770
type: UnificationXref
id: Q6C8U8
db: uniprot

uniprot O95206 811
type: UnificationXref
id: O95206
db: uniprot

uniprot F6VVA6 1100
type: UnificationXref
id: F6VVA6
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7CP86 553
xref: PTHR45619:SF44
organism: Monodelphis domestica

Frizzled class receptor 9b
type: ProteinReference
xref: uniprot B0S5E7 72
xref: PTHR11309:SF79
organism: Danio rerio

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Casein_Kinase_1-RIGHT__Casein_Kinase_1-_re65
control type: INHIBITION
controller: Complex (Dishevelled/Beta-Arrestin/ Frodo/Casein Kinase 2)

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 1310

AGAP006263-PA
type: ProteinReference
xref: PTHR11792:SF23
xref: uniprot Q7Q5Q8 1588
organism: Anopheles gambiae

uniprot P28867 1686
type: UnificationXref
id: P28867
db: uniprot

uniprot F1MMW7 1041
type: UnificationXref
id: F1MMW7
db: uniprot

uniprot F1MY82 1657
type: UnificationXref
id: F1MY82
db: uniprot

PTHR22846:SF2
type: RelationshipXref
id: PTHR22846:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10177:SF203
type: RelationshipXref
id: PTHR10177:SF203
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QTT6 1532
type: UnificationXref
id: A0A1D5QTT6
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR45615:SF35
organism: Bos taurus

uniprot F7ES96 1943
type: UnificationXref
id: F7ES96
db: uniprot

Probable histone deacetylase HOS2
type: ProteinReference
xref: PTHR10625:SF208
xref: uniprot P53096 2073
organism: Saccharomyces cerevisiae

PTHR47161:SF1
type: RelationshipXref
id: PTHR47161:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F7DHT4 2019
type: UnificationXref
id: F7DHT4
db: uniprot

PTHR46232:SF1
type: RelationshipXref
id: PTHR46232:SF1
db: PANTHER Family
relationship type: By Homology

PTHR46232:SF2
type: RelationshipXref
id: PTHR46232:SF2
db: PANTHER Family
relationship type: By Homology

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
type: ProteinReference
xref: PTHR10799:SF819
xref: uniprot F6U824 305
organism: 9258

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa30 2282
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot B8JLJ7 1441
type: UnificationXref
id: B8JLJ7
db: uniprot

uniprot F6T6M8 1729
type: UnificationXref
id: F6T6M8
db: uniprot

uniprot P97633 1832
type: UnificationXref
id: P97633
db: uniprot

uniprot Q04726 486
type: UnificationXref
id: Q04726
db: uniprot

uniprot F6RNN7 1478
type: UnificationXref
id: F6RNN7
db: uniprot

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Beta Catenin s64 sa24 rs5
feature: Threonine41 Beta Catenin s64 sa24 rs4
feature: Serine45 Beta Catenin s64 sa24 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa24 2148
feature: serine33 Beta Catenin s64 sa24 rs3
feature: Serine35 Beta Catenin s64 sa24 rs2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A4FV68 529
type: UnificationXref
id: A4FV68
db: uniprot

Actin, gamma-enteric smooth muscle
type: DnaReference
xref: PTHR11937:SF445
organism: Mus musculus

uniprot P63329 1341
type: UnificationXref
id: P63329
db: uniprot

serine33 Beta Catenin s193 sa108 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s193 sa108 rs3 serine33
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

SWI/SNF complex subunit SMARCC2
type: ProteinReference
xref: PTHR12802:SF105
xref: uniprot Q8TAQ2 421
organism: Homo sapiens

Smad4 s90 sa60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smad4
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A0G2JZD1 522
xref: PTHR10257:SF19
organism: Rattus norvegicus

PTHR11309:SF11
type: RelationshipXref
id: PTHR11309:SF11
db: PANTHER Family
relationship type: By Homology

uniprot Q9UN75 962
type: UnificationXref
id: Q9UN75
db: uniprot

uniprot A0A1D5PEJ9 64
type: UnificationXref
id: A0A1D5PEJ9
db: uniprot

uniprot P97496 371
type: UnificationXref
id: P97496
db: uniprot

CSNK1G3 isoform 8
type: ProteinReference
xref: PTHR11909:SF151
xref: uniprot A0A2I3TNT3 1789
organism: Pan troglodytes

Protocadherin beta 9
type: ProteinReference
xref: uniprot E9Q5G2 690
xref: PTHR24028:SF239
organism: Mus musculus

uniprot A0A0C4DHD7 2008
type: UnificationXref
id: A0A0C4DHD7
db: uniprot

uniprot P34888 1236
type: UnificationXref
id: P34888
db: uniprot

Smad4
type: Protein
entity reference: Smad4
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 sa60 2314
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot A0A1D5Q7V1 1531
xref: PTHR13703:SF23
organism: Macaca mulatta

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 2
type: ProteinReference
xref: uniprot E9PTG1 286
xref: PTHR10799:SF541
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PI_4,5_P2-RIGHT__DAG-_IP3-_r110
controller: Complex (Galpha/Phospholipase C)

Transducin-like Enhance of Split 1-3
type: Protein
entity reference: Transducin-like Enhance of Split 1-3
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Histone deacetylase
type: ProteinReference
xref: P01472
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Histone deacetylase
comment: ENTITY_REFERENCE_NOTES= Long Name: Histone deacetylase Synonym: Reduced potassium dependency 3,Rpd3 Accession: P01472
member entity reference: Histone deacetylase RPD3
member entity reference: Histone deacetylase
member entity reference: P56519
member entity reference: Histone deacetylase 1
member entity reference: Histone deacetylase 8
member entity reference: Histone deacetylase 7
member entity reference: Q803C3
member entity reference: Q8H0W2
member entity reference: Histone deacetylase 2
member entity reference: P56517
member entity reference: Uncharacterized protein
member entity reference: O09106
member entity reference: Q94517
member entity reference: Histone deacetylase 3
member entity reference: P56518
member entity reference: P56520
member entity reference: O22446
member entity reference: F6ULG8
member entity reference: Q13547
member entity reference: Histone deacetylase phd1
member entity reference: D3ZVU7
member entity reference: Histone deacetylase clr6
member entity reference: Probable histone deacetylase HOS2
member entity reference: Q09440
member entity reference: Q9FML2

Catenin alpha-1
type: ProteinReference
xref: uniprot Q3MHM6 2033
xref: PTHR18914:SF24
organism: Bos taurus

Arrestin-C
type: ProteinReference
xref: uniprot A0A096MJ89 1559
xref: PTHR11792:SF19
organism: Rattus norvegicus

Cadherin EGF LAG seven-pass G-type receptor 2
type: ProteinReference
xref: uniprot E2R4F0 680
xref: PTHR24026:SF32
organism: Canis lupus familiaris

Probable casein kinase II subunit beta-2
type: ProteinReference
xref: uniprot O94281 1741
xref: PTHR11740:SF24
organism: 284812

uniprot E2REF0 281
type: UnificationXref
id: E2REF0
db: uniprot

F-box-like/WD repeat-containing protein TBL1XR1
type: ProteinReference
xref: PTHR22846:SF40
xref: uniprot Q8BHJ5 1505
organism: Mus musculus

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q02956 1695
organism: Mus musculus

uniprot P62873 1629
type: UnificationXref
id: P62873
db: uniprot

PTHR12027:SF7
type: RelationshipXref
id: PTHR12027:SF7
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF34
type: RelationshipXref
id: PTHR11309:SF34
db: PANTHER Family
relationship type: By Homology

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot Q9UP38 150
organism: Homo sapiens

PTHR12027:SF3
type: RelationshipXref
id: PTHR12027:SF3
db: PANTHER Family
relationship type: By Homology

Protein Wnt-3a
type: ProteinReference
xref: PTHR12027:SF88
xref: uniprot P27467 1232
organism: Mus musculus

PTHR11309:SF31
type: RelationshipXref
id: PTHR11309:SF31
db: PANTHER Family
relationship type: By Homology

Actin, alpha 1, skeletal muscle
type: DnaReference
xref: PTHR11937:SF193
organism: Xenopus tropicalis

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F6VHF7 21
xref: PTHR13715:SF52
organism: Xenopus tropicalis

Axin s189 sa104 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot A9UJN4 531
xref: PTHR10257:SF3
organism: Caenorhabditis elegans

uniprot E9AEZ4 1722
type: UnificationXref
id: E9AEZ4
db: uniprot

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Threonine41 Beta Catenin s69 sa29 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa29 2280
feature: Serine35 Beta Catenin s69 sa29 rs2
feature: Serine45 Beta Catenin s69 sa29 rs1
feature: Beta Catenin s69 sa29 rs5
feature: serine33 Beta Catenin s69 sa29 rs3
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P32120 1582
type: UnificationXref
id: P32120
db: uniprot

PTHR11309:SF22
type: RelationshipXref
id: PTHR11309:SF22
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF23
type: RelationshipXref
id: PTHR11309:SF23
db: PANTHER Family
relationship type: By Homology

uniprot E1BDG5 1159
type: UnificationXref
id: E1BDG5
db: uniprot

uniprot F8VPK8 778
type: UnificationXref
id: F8VPK8
db: uniprot

Serine35 Beta Catenin s232 a380 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s232 a380 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot P0C8E4 1066
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re65 2499
type: Stoichiometry
physical entity: Casein Kinase 1
stoichiometric coefficient: 1.0

uniprot Q9FMT4 433
type: UnificationXref
id: Q9FMT4
db: uniprot

uniprot F7HNS7 1057
type: UnificationXref
id: F7HNS7
db: uniprot

uniprot P29295 1816
type: UnificationXref
id: P29295
db: uniprot

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
type: ProteinReference
xref: uniprot Q5ZK40 392
xref: PTHR10019:SF5
organism: 9031

uniprot O57328 113
type: UnificationXref
id: O57328
db: uniprot

DiSHevelled related
type: ProteinReference
xref: uniprot Q18239 1392
xref: PTHR10878:SF25
organism: Caenorhabditis elegans

GDP
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Chromatin-remodeling ATPase INO80
type: ProteinReference
xref: PTHR45685:SF2
xref: uniprot P53115 365
organism: Saccharomyces cerevisiae

uniprot Q9XWB7 1122
type: UnificationXref
id: Q9XWB7
db: uniprot

Dachsous cadherin-related 1
type: ProteinReference
xref: PTHR24027:SF423
xref: uniprot E1B969 670
organism: Bos taurus

Cerebus
type: Protein
entity reference: Cerebus
comment: SPECIES_TYPE=PROTEIN

uniprot E2RN43 284
type: UnificationXref
id: E2RN43
db: uniprot

Axin
type: Protein
entity reference: Axin
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa32 2176
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR11309:SF47
type: RelationshipXref
id: PTHR11309:SF47
db: PANTHER Family
relationship type: By Homology

AT-rich interaction domain 1B
type: ProteinReference
xref: uniprot A0A3Q1MXM3 260
xref: PTHR12656:SF11
organism: Bos taurus

Protein Wnt-10a
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot P43446 1240
organism: Danio rerio

ncbitaxon 7227 35
type: UnificationXref
id: 7227
db: ncbitaxon

PTHR11309:SF46
type: RelationshipXref
id: PTHR11309:SF46
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF45
type: RelationshipXref
id: PTHR11309:SF45
db: PANTHER Family
relationship type: By Homology

uniprot G7NGI5 1424
type: UnificationXref
id: G7NGI5
db: uniprot

uniprot P43289 1021
type: UnificationXref
id: P43289
db: uniprot

uniprot F6QL95 88
type: UnificationXref
id: F6QL95
db: uniprot

PTHR11309:SF75
type: RelationshipXref
id: PTHR11309:SF75
db: PANTHER Family
relationship type: By Homology

uniprot E7FAU6 687
type: UnificationXref
id: E7FAU6
db: uniprot

PTHR11309:SF79
type: RelationshipXref
id: PTHR11309:SF79
db: PANTHER Family
relationship type: By Homology

MODULATION
type: TemplateReactionRegulation
xref: MODULATION
controlled: TRANSCRIPTION_LEFT__NFAT_Target_Genes-RIGHT__NAFT_Target_Genes-_re68
controller: NFAT

uniprot Q7QE14 409
type: UnificationXref
id: Q7QE14
db: uniprot

uniprot E2RDT2 1163
type: UnificationXref
id: E2RDT2
db: uniprot

uniprot A8X402 1141
type: UnificationXref
id: A8X402
db: uniprot

uniprot H2QJY5 1103
type: UnificationXref
id: H2QJY5
db: uniprot

Cadherin-10 preproprotein
type: ProteinReference
xref: uniprot F7DRD8 756
xref: PTHR24027:SF290
organism: Macaca mulatta

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 4

Alpha-catenin-like protein hmp-1
type: ProteinReference
xref: uniprot P90947 2032
organism: Caenorhabditis elegans

uniprot F5HH30 1605
type: UnificationXref
id: F5HH30
db: uniprot

PTHR13844:SF7
type: RelationshipXref
id: PTHR13844:SF7
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re66 2491
type: Stoichiometry
physical entity: Complex (TCF/Smad4)
stoichiometric coefficient: 1.0

AGAP007207-PA
type: ProteinReference
xref: PTHR24026:SF108
xref: uniprot A0NBC9 658
organism: Anopheles gambiae

PTHR13844:SF2
type: RelationshipXref
id: PTHR13844:SF2
db: PANTHER Family
relationship type: By Homology

PTHR13844:SF1
type: RelationshipXref
id: PTHR13844:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F6YUQ2 1522
type: UnificationXref
id: F6YUQ2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot P43425 1960
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re66 2492
type: Stoichiometry
physical entity: Complex (TCF/Smad4)
stoichiometric coefficient: 1.0

PTHR13844:SF5
type: RelationshipXref
id: PTHR13844:SF5
db: PANTHER Family
relationship type: By Homology

Transducin like enhancer of split 4
type: ProteinReference
xref: uniprot F1PDW7 466
xref: PTHR10814:SF31
organism: Canis lupus familiaris

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot Q84RS4 1775
xref: PTHR11740:SF0
organism: Oryza sativa

uniprot F6ZXH1 743
type: UnificationXref
id: F6ZXH1
db: uniprot

TCF s79 sa50 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q08174 842
type: UnificationXref
id: Q08174
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot P70227 39
xref: PTHR13715:SF51
organism: Mus musculus

Casein Kinase 1
type: Protein
entity reference: Casein Kinase 1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1PS63 1046
organism: Canis lupus familiaris

Cadherin-4
type: ProteinReference
xref: PTHR24025:SF23
xref: uniprot Q19319 848
organism: Caenorhabditis elegans

AGAP005911-PA
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot Q7Q6D4 1641
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y0D3 198
organism: 7668

AGAP005913-PA
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot Q7Q6D2 1639
organism: Anopheles gambiae

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 1640
xref: PTHR19850:SF25
organism: Anopheles gambiae

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot P28548 1750
xref: PTHR11740:SF0
organism: Caenorhabditis elegans

PTHR15936:SF2
type: RelationshipXref
id: PTHR15936:SF2
db: PANTHER Family
relationship type: By Homology

uniprot F6RNC2 1880
type: UnificationXref
id: F6RNC2
db: uniprot

STATE_TRANSITION_LEFT__Protein_Kinase_C-RIGHT__Protein_Kinase_C-_r76
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 2414
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 2413
left: Protein Kinase C
interaction type: STATE_TRANSITION
right: Protein Kinase C

uniprot F7EN59 231
type: UnificationXref
id: F7EN59
db: uniprot

Guanine nucleotide binding protein 13, gamma-like
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot E1B8Q3 1920
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot O89040 1108
xref: PTHR10336:SF10
organism: Rattus norvegicus

uniprot Q9D0P5 1915
type: UnificationXref
id: Q9D0P5
db: uniprot

F-box/WD repeat-containing protein 1A
type: ProteinReference
xref: uniprot Q9Y297 1530
xref: PTHR19854:SF16
organism: Homo sapiens

PTHR11471:SF23
type: RelationshipXref
id: PTHR11471:SF23
db: PANTHER Family
relationship type: By Homology

uniprot F6XMD3 1182
type: UnificationXref
id: F6XMD3
db: uniprot

Cadherin 11
type: ProteinReference
xref: PTHR24027:SF85
xref: uniprot F1MAH6 701
organism: Rattus norvegicus

PTHR24054:SF16
type: RelationshipXref
id: PTHR24054:SF16
db: PANTHER Family
relationship type: By Homology

uniprot Q6ZB59 2088
type: UnificationXref
id: Q6ZB59
db: uniprot

LDL receptor related protein 6
type: ProteinReference
xref: uniprot F7CQF2 177
xref: PTHR24270:SF12
organism: 9258

uniprot A0A2I3SXI2 1010
type: UnificationXref
id: A0A2I3SXI2
db: uniprot

Helicase SRCAP
type: ProteinReference
xref: PTHR45685:SF1
xref: uniprot Q6ZRS2 404
organism: Homo sapiens

Beta-Arrestin
type: Protein
entity reference: Beta-Arrestin
feature: COMPLEX PARTICIPANT BINDING FEATURE s147 sa132 2296
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Brahma associated protein 155 kDa
type: ProteinReference
xref: PTHR12802:SF41
xref: uniprot Q9VF03 447
organism: Drosophila melanogaster

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 1615
xref: PTHR19850:SF28
organism: Pan troglodytes

uniprot E9FUX0 1603
type: UnificationXref
id: E9FUX0
db: uniprot

uniprot A0A2I3TNT3 1789
type: UnificationXref
id: A0A2I3TNT3
db: uniprot

TLE4 isoform 7
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot A0A2I3S488 457
organism: Pan troglodytes

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot H2RCY2 1062
organism: Pan troglodytes

Frizzled class receptor 8
type: ProteinReference
xref: PTHR11309:SF90
xref: uniprot H2R050 108
organism: Pan troglodytes

Alpha-cardiac actin
type: DnaReference
xref: PTHR11937:SF176
organism: Macaca mulatta

Frizzled-8
type: ProteinReference
xref: PTHR11309:SF90
xref: uniprot Q498S8 123
organism: Rattus norvegicus

uniprot A0A2R9YJJ0 1490
type: UnificationXref
id: A0A2R9YJJ0
db: uniprot

uniprot K7CHS6 159
type: UnificationXref
id: K7CHS6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ECA6 1446
xref: PTHR10218:SF328
organism: Monodelphis domestica

Protocadherin 11 X-linked (Predicted)
type: ProteinReference
xref: uniprot D4A497 666
xref: PTHR24028:SF254
organism: Rattus norvegicus

uniprot D3ZTV6 227
type: UnificationXref
id: D3ZTV6
db: uniprot

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot A0A3Q1LSA1 1033
organism: Bos taurus

uniprot F7D992 754
type: UnificationXref
id: F7D992
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot F6X958 550
organism: Canis lupus familiaris

uniprot F7CTP1 1610
type: UnificationXref
id: F7CTP1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BJ11 675
xref: PTHR24025:SF17
organism: Bos taurus

DVL3 isoform 1
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot H2QNU7 1387
organism: Pan troglodytes

uniprot F1MN70 1168
type: UnificationXref
id: F1MN70
db: uniprot

uniprot P56518 2075
type: UnificationXref
id: P56518
db: uniprot

Cadherin-89D
type: ProteinReference
xref: uniprot Q9VEU1 965
xref: PTHR24026:SF89
organism: Drosophila melanogaster

Dishevelled-binding antagonist of beta-catenin 1
type: ProteinReference
xref: uniprot D4A3W8 2002
xref: PTHR15919:SF12
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: uniprot D4A3W9 1156
xref: PTHR12027:SF72
organism: Rattus norvegicus

uniprot Q9UP38 150
type: UnificationXref
id: Q9UP38
db: uniprot

uniprot P48463 566
type: UnificationXref
id: P48463
db: uniprot

uniprot Q9NYF0 2007
type: UnificationXref
id: Q9NYF0
db: uniprot

uniprot Q9VB23 596
type: UnificationXref
id: Q9VB23
db: uniprot

uniprot P50153 1963
type: UnificationXref
id: P50153
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 1984
xref: PTHR13809:SF9
organism: Mus musculus

uniprot P40235 1822
type: UnificationXref
id: P40235
db: uniprot

Axin s178 sa96 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin s178 sa96
stoichiometric coefficient: 1.0

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F6TED2 203
organism: Macaca mulatta

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05771 1676
organism: Homo sapiens

SWI/SNF complex subunit SWI3
type: ProteinReference
xref: PTHR12802:SF41
xref: uniprot P32591 357
organism: Saccharomyces cerevisiae

Nuclear protein STH1/NPS1
type: ProteinReference
xref: uniprot P32597 358
xref: PTHR10799:SF854
organism: Saccharomyces cerevisiae

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot A0A1D5R985 1644
organism: Macaca mulatta

Adenylosuccinate synthetase 2
type: DnaReference
xref: PTHR11846:SF0
organism: Methanosarcina acetivorans

Adenomatous Polyposis Coli
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s116 sa88 2190
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot O96014 1219
type: UnificationXref
id: O96014
db: uniprot

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 2000

PARTICIPANT STOICHIOMETRY r64 2462
type: Stoichiometry
physical entity: Complex (TCF/Beta-Catenin/ Smad4/Bcl9)
stoichiometric coefficient: 1.0

TLE family member 2, transcriptional corepressor
type: ProteinReference
xref: PTHR10814:SF4
xref: uniprot E9PTW9 463
organism: Rattus norvegicus

Frizzled class receptor 5
type: ProteinReference
xref: uniprot F1MGM1 81
xref: PTHR11309:SF136
organism: Bos taurus

uniprot Q9QXN1 516
type: UnificationXref
id: Q9QXN1
db: uniprot

uniprot Q8R4A3 2004
type: UnificationXref
id: Q8R4A3
db: uniprot

Protocadherin-12
type: ProteinReference
xref: uniprot O55134 804
xref: PTHR24028:SF42
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r64 2461
type: Stoichiometry
physical entity: Complex (TCF/Smad4/ Beta-Catenin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 2460
type: Stoichiometry
physical entity: Bcl9 s170 a416
stoichiometric coefficient: 1.0

uniprot A0A3Q1LSA1 1033
type: UnificationXref
id: A0A3Q1LSA1
db: uniprot

Casein kinase 2 alpha 2
type: ProteinReference
xref: PTHR24054:SF34
xref: uniprot B4F7A9 1718
organism: Rattus norvegicus

Axin s63 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 45

uniprot E2R7K4 1923
type: UnificationXref
id: E2R7K4
db: uniprot

uniprot Q95RJ9 1506
type: UnificationXref
id: Q95RJ9
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 1927
xref: PTHR13809:SF19
organism: Bos taurus

Actin, alpha 2, smooth muscle, aorta
type: DnaReference
xref: PTHR11937:SF201
organism: 9258

Protocadherin-7
type: ProteinReference
xref: PTHR24028:SF253
xref: uniprot O60245 805
organism: Homo sapiens

uniprot A0A1D5RAC8 455
type: UnificationXref
id: A0A1D5RAC8
db: uniprot

uniprot P40231 1754
type: UnificationXref
id: P40231
db: uniprot

TCF
type: Protein
entity reference: TCF
feature: COMPLEX PARTICIPANT BINDING FEATURE s83 sa53 2266
feature: TCF s83 sa53 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q8LPJ1 1852
type: UnificationXref
id: Q8LPJ1
db: uniprot

uniprot Q61151 585
type: UnificationXref
id: Q61151
db: uniprot

uniprot F6UDX0 725
type: UnificationXref
id: F6UDX0
db: uniprot

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

uniprot Q10Q71 1763
type: UnificationXref
id: Q10Q71
db: uniprot

Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
type: ProteinReference
xref: uniprot Q7X9V2 411
xref: PTHR45685:SF1
organism: Arabidopsis thaliana

Protocadherin beta 7
type: ProteinReference
xref: uniprot Q8CDY9 893
xref: PTHR24028:SF148
organism: Mus musculus

Protocadherin-9
type: ProteinReference
xref: uniprot F6WDU9 734
xref: PTHR24028:SF248
organism: Macaca mulatta

Transcription activator BRG1
type: ProteinReference
xref: uniprot Q8K1P7 416
xref: PTHR10799:SF76
organism: Rattus norvegicus

Lymphoid enhancer binding factor 1
type: ProteinReference
xref: PTHR10373:SF11
xref: uniprot A0A3Q1MZ99 502
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r65 2453
type: Stoichiometry
physical entity: Complex (Bcl9/Beta-Catenin/ TCF/Smad4/ Pygo)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r65 2452
type: Stoichiometry
physical entity: Complex (TCF/Beta-Catenin/ Smad4/Bcl9)
stoichiometric coefficient: 1.0

uniprot Q9FVS6 1026
type: UnificationXref
id: Q9FVS6
db: uniprot

PARTICIPANT STOICHIOMETRY r65 2451
type: Stoichiometry
physical entity: Pygo s171 a387
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MYU1 290
xref: PTHR12802:SF9
organism: Bos taurus

PTHR24055:SF380
type: RelationshipXref
id: PTHR24055:SF380
db: PANTHER Family
relationship type: By Homology

uniprot F7CX56 753
type: UnificationXref
id: F7CX56
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F1MAA3 540
xref: PTHR10257:SF89
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot P16054 1681
xref: PTHR24356:SF159
organism: Mus musculus

uniprot Q13485 1550
type: UnificationXref
id: Q13485
db: uniprot

uniprot A0A2I3RN05 635
type: UnificationXref
id: A0A2I3RN05
db: uniprot

Kremen protein 2
type: ProteinReference
xref: uniprot Q8K1S7 1901
organism: Mus musculus

Cadherin-16
type: ProteinReference
xref: uniprot O75309 807
xref: PTHR24028:SF1
organism: Homo sapiens

uniprot Q9BY41 2100
type: UnificationXref
id: Q9BY41
db: uniprot

uniprot D4A182 54
type: UnificationXref
id: D4A182
db: uniprot

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
type: ProteinReference
xref: PTHR10799:SF879
xref: uniprot O60264 347
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot O60262 1958
organism: Homo sapiens

Histone deacetylase RPD3
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot P32561 2072
organism: Saccharomyces cerevisiae

uniprot Q6PFX6 873
type: UnificationXref
id: Q6PFX6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF133
xref: uniprot F1NHI6 1879
organism: 9031

AGAP005569-PA
type: ProteinReference
xref: uniprot Q7Q707 1773
xref: PTHR24054:SF0
organism: Anopheles gambiae

Protein CBR-MOM-5
type: ProteinReference
xref: uniprot A8WWU4 71
xref: PTHR11309:SF47
organism: Caenorhabditis briggsae

uniprot E2RJ89 282
type: UnificationXref
id: E2RJ89
db: uniprot

RCG24403, isoform CRA_a
type: ProteinReference
xref: uniprot Q5U3Y2 390
xref: PTHR13844:SF5
organism: Rattus norvegicus

Nemo like Kinase s235 a497 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P97471 1548
type: UnificationXref
id: P97471
db: uniprot

PTHR11846:SF13
type: RelationshipXref
id: PTHR11846:SF13
db: PANTHER Family
relationship type: By Homology

uniprot P68404 1692
type: UnificationXref
id: P68404
db: uniprot

uniprot Q9Z0H3 451
type: UnificationXref
id: Q9Z0H3
db: uniprot

uniprot A0A3Q1MPF5 1135
type: UnificationXref
id: A0A3Q1MPF5
db: uniprot

Axin
type: Protein
entity reference: Axin
feature: COMPLEX PARTICIPANT BINDING FEATURE s53 sa44 2290
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9VYG2 448
type: UnificationXref
id: Q9VYG2
db: uniprot

uniprot Q61091 129
type: UnificationXref
id: Q61091
db: uniprot

uniprot Q7KTS4 2092
type: UnificationXref
id: Q7KTS4
db: uniprot

DISSOCIATION
type: InteractionVocabulary

Transducin (Beta)-like 1X-linked receptor 1 (Predicted)
type: ProteinReference
xref: uniprot D3ZNF4 1494
xref: PTHR22846:SF40
organism: Rattus norvegicus

HETERODIMER ASSOCIATION LEFT betaTrCP- Complex Adenomatous Polyposis Coli Beta Catenin Glycogen Synthase Kinase 3Beta Axin PP2A Diversin Casein Kinase 1 -RIGHT Complex Adenomatous Polyposis Coli Axin PP2A Diversin Casein Kinase 1 Beta Catenin betaTrCP Glycogen Synthase Kinase 3Beta - r88
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 2511
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 2509
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 2510
left: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Glycogen Synthase Kinase-3Beta/Axin/ PP2A/Diversin/ Casein Kinase 1)
left: betaTrCP
display name: HETERODIMER_ASSOCIATION_LEFT__betaTrCP-_Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Glycogen_Synthase_Kinase_3Beta_Axin__PP2A_Diversin__Casein_Kinase_1_-RIGHT__Complex__Adenomatous_Polyposis_Coli_Axin__PP2A_Diversin__Casein_Kinase_1_Beta_Catenin__betaTrCP_Glycogen_Synthase_Kinase_3Beta_-_r88
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Adenomatous Polyposis Coli/Axin/ PP2A/Diversin/ Casein Kinase 1/Beta-Catenin/ betaTrCP/Glycogen Synthase Kinase-3Beta)

uniprot E2R3R6 1038
type: UnificationXref
id: E2R3R6
db: uniprot

uniprot P55285 829
type: UnificationXref
id: P55285
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1P3H0 1044
organism: 9031

uniprot Q9Y5F9 985
type: UnificationXref
id: Q9Y5F9
db: uniprot

uniprot Q6IQV0 1772
type: UnificationXref
id: Q6IQV0
db: uniprot

Tumor necrosis factor
type: DnaReference
xref: PTHR11471:SF23
organism: Bos taurus

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot H2QNL0 206
organism: Pan troglodytes

uniprot F7FPX9 1804
type: UnificationXref
id: F7FPX9
db: uniprot

PARTICIPANT STOICHIOMETRY r80 2387
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r80 2385
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r80 2386
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

uniprot Q91VE5 910
type: UnificationXref
id: Q91VE5
db: uniprot

Complex (Histone deacetylase/Transducin-like Enhance of Split 1-3)
type: Complex
component stoichiometry: Histone deacetylase s55 sa48 STOICHIOMETRY ID COMPLEX
component stoichiometry: Transducin like Enhance of Split 1 3 s56 sa49 STOICHIOMETRY ID COMPLEX
component: Histone deacetylase
component: Transducin-like Enhance of Split 1-3
feature: COMPLEX BINDING FEATURE s175 a395 2221
feature: COMPLEX BINDING FEATURE s175 a395 2219
cellular location: nucleus

Beta Catenin s141 sa126 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Bone morphogenetic protein receptor type-1A
type: ProteinReference
xref: uniprot P36894 1067
organism: Homo sapiens

Casein kinase 1 gamma 3
type: ProteinReference
xref: PTHR11909:SF151
xref: uniprot J9P9W3 1811
organism: Canis lupus familiaris

T-box transcription factor T
type: DnaReference
xref: PTHR11267:SF83
organism: Mus musculus

Activin receptor type-1B
type: ProteinReference
xref: uniprot P36896 1069
organism: Homo sapiens

ncbitaxon 9913 10
type: UnificationXref
id: 9913
db: ncbitaxon

Bone morphogenetic protein receptor type-1A
type: ProteinReference
xref: uniprot P36895 1068
organism: Mus musculus

Bone morphogenetic protein receptor type-1B
type: ProteinReference
xref: uniprot P36898 1071
organism: Mus musculus

TGF-beta receptor type-1
type: ProteinReference
xref: uniprot P36897 1070
organism: Homo sapiens

uniprot A0A2I3S359 252
type: UnificationXref
id: A0A2I3S359
db: uniprot

uniprot Q8NCW0 1902
type: UnificationXref
id: Q8NCW0
db: uniprot

uniprot Q9Z1Y3 1009
type: UnificationXref
id: Q9Z1Y3
db: uniprot

Mothers against decapentaplegic homolog 5
type: ProteinReference
xref: uniprot Q56I99 1553
xref: PTHR13703:SF36
organism: 9031

uniprot F6XQL7 308
type: UnificationXref
id: F6XQL7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QHG9 629
xref: PTHR24028:SF247
organism: Macaca mulatta

uniprot Q8WN91 903
type: UnificationXref
id: Q8WN91
db: uniprot

uniprot Q5DRC6 855
type: UnificationXref
id: Q5DRC6
db: uniprot

uniprot F7BWZ1 1882
type: UnificationXref
id: F7BWZ1
db: uniprot

PARTICIPANT STOICHIOMETRY r6 2390
type: Stoichiometry
physical entity: Complex (Dickkopf/Kremen)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BXD9 750
xref: PTHR24027:SF423
organism: Macaca mulatta

uniprot P28370 356
type: UnificationXref
id: P28370
db: uniprot

Protein CBG09510
type: ProteinReference
xref: uniprot A8X8Y1 1792
xref: PTHR11909:SF297
organism: Caenorhabditis briggsae

Nuclear factor of activated T cells 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot F1MGR9 1475
organism: Bos taurus

uniprot A9THD0 1717
type: UnificationXref
id: A9THD0
db: uniprot

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot F1MAD0 171
xref: PTHR46513:SF16
organism: Rattus norvegicus

uniprot Q7PR41 879
type: UnificationXref
id: Q7PR41
db: uniprot

Frodo
type: Protein
entity reference: Frodo PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s145 sa130 2338
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r6 2388
type: Stoichiometry
physical entity: Kremen
stoichiometric coefficient: 1.0

uniprot Q14527 377
type: UnificationXref
id: Q14527
db: uniprot

PARTICIPANT STOICHIOMETRY r6 2389
type: Stoichiometry
physical entity: Dickkopf
stoichiometric coefficient: 1.0

Casein kinase I gamma
type: ProteinReference
xref: uniprot Q8WQ99 1858
xref: PTHR11909:SF155
organism: Caenorhabditis elegans

ncbitaxon 7739 537
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot P05129 1674
type: UnificationXref
id: P05129
db: uniprot

AGAP000923-PA
type: ProteinReference
xref: uniprot Q7QI39 410
xref: PTHR13844:SF7
organism: Anopheles gambiae

uniprot Q8K1S7 1901
type: UnificationXref
id: Q8K1S7
db: uniprot

uniprot E1C795 1921
type: UnificationXref
id: E1C795
db: uniprot

betaTrCP s200 sa109 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: betaTrCP
stoichiometric coefficient: 1.0

AGAP001154-PA
type: ProteinReference
xref: uniprot Q7PUT1 407
xref: PTHR10019:SF5
organism: Anopheles gambiae

uniprot Q8R4T2 219
type: UnificationXref
id: Q8R4T2
db: uniprot

uniprot A7MB90 1790
type: UnificationXref
id: A7MB90
db: uniprot

uniprot Q7Q707 1773
type: UnificationXref
id: Q7Q707
db: uniprot

uniprot Q91XZ8 918
type: UnificationXref
id: Q91XZ8
db: uniprot

AGAP011770-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PV65 183
xref: PTHR46513:SF24
organism: Anopheles gambiae

uniprot Q8CDY9 893
type: UnificationXref
id: Q8CDY9
db: uniprot

Casein Kinase 2 s151 sa136 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Casein Kinase 2
stoichiometric coefficient: 1.0

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot Q56IA0 1554
xref: PTHR13703:SF23
organism: 9031

uniprot Q1JQA2 1552
type: UnificationXref
id: Q1JQA2
db: uniprot

uniprot Q6STE5 402
type: UnificationXref
id: Q6STE5
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot P09217 1679
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot P09216 1678
xref: PTHR24356:SF159
organism: Rattus norvegicus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P09215 1677
organism: Rattus norvegicus

PTHR10177:SF67
type: RelationshipXref
id: PTHR10177:SF67
db: PANTHER Family
relationship type: By Homology

uniprot Q9ULB5 954
type: UnificationXref
id: Q9ULB5
db: uniprot

uniprot Q60996 584
type: UnificationXref
id: Q60996
db: uniprot

Dishevelled
type: Protein
entity reference: Dishevelled
feature: COMPLEX PARTICIPANT BINDING FEATURE s146 sa131 2294
feature: Dishevelled s146 sa131 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q5DRC8 857
type: UnificationXref
id: Q5DRC8
db: uniprot

uniprot P48729 1825
type: UnificationXref
id: P48729
db: uniprot

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
type: ProteinReference
xref: PTHR13844:SF2
xref: uniprot E1BJD1 276
organism: Bos taurus

uniprot Q9Y6N8 1007
type: UnificationXref
id: Q9Y6N8
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 1609
xref: PTHR19850:SF28
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot F7H3B3 1665
organism: Macaca mulatta

Uncharacterized protein
type: DnaReference
xref: PTHR11937:SF446
organism: 7739

AGAP001591-PA
type: ProteinReference
xref: uniprot Q7PUW9 881
xref: PTHR24028:SF298
organism: Anopheles gambiae

uniprot E2RDC4 1518
type: UnificationXref
id: E2RDC4
db: uniprot

uniprot Q80V76 1913
type: UnificationXref
id: Q80V76
db: uniprot

uniprot F7G015 473
type: UnificationXref
id: F7G015
db: uniprot

uniprot P17553 1224
type: UnificationXref
id: P17553
db: uniprot

Casein Kinase 2
type: ProteinReference
xref: P01459
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Casein Kinase 2
comment: ENTITY_REFERENCE_NOTES= Long Name: Casein Kinase 2 Synonym: Casein Kinase II,Protein Kinase CK2 Accession: P01459
member entity reference: Casein kinase 2, alpha prime polypeptide a
member entity reference: AGAP005569-PA
member entity reference: Casein kinase II subunit alpha
member entity reference: A7F2U3
member entity reference: CSNK2A1 isoform 3
member entity reference: Casein kinase II subunit beta
member entity reference: F6RN85
member entity reference: P67870
member entity reference: Casein kinase II, alpha chain, putative, expressed
member entity reference: Predicted protein
member entity reference: Q6IQV0
member entity reference: A0A1D5RD87
member entity reference: Casein kinase II subunit beta'
member entity reference: Casein kinase II subunit beta-1
member entity reference: YALI0D16863p
member entity reference: Protein CBR-KIN-3
member entity reference: Uncharacterized protein
member entity reference: CSNK2A2 isoform 1
member entity reference: Casein kinase II subunit alpha'
member entity reference: Putative casein kinase II
member entity reference: Casein kinase II subunit beta-2
member entity reference: O54833
member entity reference: Q8T3S5
member entity reference: Casein kinase II subunit alpha-3
member entity reference: Casein kinase 2 alpha 2
member entity reference: Putative casein kinase II subunit beta-4
member entity reference: Casein kinase II subunit alpha 3
member entity reference: Casein kinase 2 beta
member entity reference: P67871
member entity reference: Casein kinase II subunit alpha-4, chloroplastic
member entity reference: P67874
member entity reference: Casein kinase II, putative
member entity reference: Q8H386
member entity reference: Probable casein kinase II subunit beta-2
member entity reference: Casein kinase II subunit beta-3
member entity reference: P67868
member entity reference: Q60737
member entity reference: Protein serine/threonine kinase
member entity reference: P38930

Protein Wnt
type: ProteinReference
xref: uniprot D3ZND6 1153
xref: PTHR12027:SF94
organism: Rattus norvegicus

Cadherin 74A, isoform A
type: ProteinReference
xref: PTHR24026:SF106
xref: uniprot Q9VVG0 967
organism: Drosophila melanogaster

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 2
type: ProteinReference
xref: PTHR12802:SF105
xref: uniprot D4A510 273
organism: Rattus norvegicus

Complex (Beta-Catenin/TCF/ Smad4/Bcl9/ Pygo/SWI/ SNF)
type: Complex
component stoichiometry: SWI SNF s97 sa67 STOICHIOMETRY ID COMPLEX
component stoichiometry: Bcl9 s95 sa65 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCF s93 sa63 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Catenin s92 sa62 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pygo s96 sa66 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smad4 s94 sa64 STOICHIOMETRY ID COMPLEX
component: TCF
component: Bcl9 s95 sa65
component: Pygo
component: Smad4
component: Beta-Catenin
component: SWI/SNF
feature: COMPLEX BINDING FEATURE s188 a435 2255
feature: COMPLEX BINDING FEATURE s188 a435 2263
feature: COMPLEX BINDING FEATURE s188 a435 2253
feature: COMPLEX BINDING FEATURE s188 a435 2261
feature: ACTIVE 50
feature: COMPLEX BINDING FEATURE s188 a435 2257
feature: COMPLEX BINDING FEATURE s188 a435 2259
cellular location: nucleus

PARTICIPANT STOICHIOMETRY r100 2519
type: Stoichiometry
physical entity: Complex Beta Catenin Cadherin alpha Catenin s282 a587
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot F6U717 1178
organism: Macaca mulatta

uniprot Q9NYQ7 946
type: UnificationXref
id: Q9NYQ7
db: uniprot

uniprot F6SV50 1049
type: UnificationXref
id: F6SV50
db: uniprot

Ankyrin repeat domain-containing protein 6 isoform a
type: ProteinReference
xref: uniprot F7EBN2 1992
xref: PTHR24203:SF7
organism: Macaca mulatta

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
type: ProteinReference
xref: PTHR10799:SF819
xref: uniprot F1P3Q4 292
organism: 9031

Complex (Dishevelled/Casein Kinase 2/ Beta-Arrestin/Frodo/ FRAT)
type: Complex
component stoichiometry: Dishevelled s150 sa135 STOICHIOMETRY ID COMPLEX
component stoichiometry: FRAT s154 sa139 STOICHIOMETRY ID COMPLEX
component stoichiometry: Frodo s153 sa138 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Arrestin s152 sa137 STOICHIOMETRY ID COMPLEX
component stoichiometry: Casein Kinase 2 s151 sa136 STOICHIOMETRY ID COMPLEX
component: Dishevelled
component: FRAT s154 sa139
component: Frodo s153 sa138
component: Beta-Arrestin
component: Casein Kinase 2
feature: COMPLEX BINDING FEATURE s292 a616 2353
feature: COMPLEX BINDING FEATURE s292 a616 2357
feature: COMPLEX BINDING FEATURE s292 a616 2351
feature: ACTIVE 50
feature: COMPLEX BINDING FEATURE s292 a616 2355
feature: COMPLEX BINDING FEATURE s292 a616 2359
cellular location: plasma membrane

Histone deacetylase clr6
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot O59702 2070
organism: 284812

uniprot P32561 2072
type: UnificationXref
id: P32561
db: uniprot

Myosin heavy chain 6
type: DnaReference
xref: PTHR45615:SF11
organism: Pan troglodytes

Cadherin 88C
type: ProteinReference
xref: uniprot Q9VFH5 966
xref: PTHR24028:SF298
organism: Drosophila melanogaster

Ebi
type: Protein
entity reference: Ebi
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa42 2234
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q22033 1834
type: UnificationXref
id: Q22033
db: uniprot

Frizzled
type: Protein
entity reference: Frizzled
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa2 2188
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Lymphoid enhancer binding factor 1
type: ProteinReference
xref: uniprot A0A2I3SSM9 500
xref: PTHR10373:SF11
organism: Pan troglodytes

uniprot E2R9S7 2014
type: UnificationXref
id: E2R9S7
db: uniprot

uniprot A0A3Q2UD13 12
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR45851:SF3
organism: 7668

Protein Wnt
type: ProteinReference
xref: uniprot M0R9D3 1211
xref: PTHR12027:SF78
organism: Rattus norvegicus

uniprot D4ACX8 668
type: UnificationXref
id: D4ACX8
db: uniprot

uniprot E9GCV0 1723
type: UnificationXref
id: E9GCV0
db: uniprot

Ebi s18 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ebi
stoichiometric coefficient: 1.0

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
type: ProteinReference
xref: PTHR13844:SF1
xref: uniprot Q96GM5 428
organism: Homo sapiens

uniprot F7DKU1 1318
type: UnificationXref
id: F7DKU1
db: uniprot

TCF
type: Protein
entity reference: TCF
feature: COMPLEX PARTICIPANT BINDING FEATURE s106 sa73 2170
feature: TCF s106 sa73 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Leishmania major
type: BioSource
xref: ncbitaxon 5664 1354

Ankyrin repeat domain-containing protein 6
type: ProteinReference
xref: uniprot Q69ZU8 1994
xref: PTHR24203:SF7
organism: Mus musculus

Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Glycogen Synthase Kinase-3Beta/Axin/ PP2A/Diversin/ Casein Kinase 1)
type: Complex
component stoichiometry: PP2A s124 sa92 STOICHIOMETRY ID COMPLEX
component stoichiometry: Diversin s125 sa93 STOICHIOMETRY ID COMPLEX
component stoichiometry: Axin s122 sa91 STOICHIOMETRY ID COMPLEX
component stoichiometry: Adenomatous Polyposis Coli s116 sa88 STOICHIOMETRY ID COMPLEX
component stoichiometry: Casein Kinase 1 s126 sa94 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glycogen Synthase Kinase 3Beta s118 sa90 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Catenin s117 sa89 STOICHIOMETRY ID COMPLEX
component: Axin
component: Diversin
component: Casein Kinase 1
component: PP2A
component: Beta-Catenin
component: Adenomatous Polyposis Coli
component: Glycogen Synthase Kinase 3Beta s118 sa90
feature: COMPLEX BINDING FEATURE s252 a524 2199
feature: COMPLEX BINDING FEATURE s252 a524 2197
feature: COMPLEX BINDING FEATURE s252 a524 2193
feature: COMPLEX BINDING FEATURE s252 a524 2195
feature: COMPLEX BINDING FEATURE s252 a524 2201
feature: COMPLEX BINDING FEATURE s252 a524 2191
feature: COMPLEX BINDING FEATURE s252 a524 2189
cellular location: plasma membrane

Galpha s163 sa79 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

uniprot F6YA42 1536
type: UnificationXref
id: F6YA42
db: uniprot

Mothers against decapentaplegic homolog 5
type: ProteinReference
xref: uniprot Q9R1V3 1558
xref: PTHR13703:SF36
organism: Rattus norvegicus

uniprot P62879 1631
type: UnificationXref
id: P62879
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot Q7PD38 590
organism: Anopheles gambiae

serine33 Beta Catenin s232 a380 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s232 a380 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

uniprot E9Q9Q6 691
type: UnificationXref
id: E9Q9Q6
db: uniprot

Casein Kinase 1 s182 sa99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Casein Kinase 1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r100 2520
type: Stoichiometry
physical entity: alpha-Catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r100 2521
type: Stoichiometry
physical entity: Complex (Beta-Catenin/Cadherin)
stoichiometric coefficient: 1.0

Lymphocyte enhancer binding factor 1
type: ProteinReference
xref: uniprot Q9W7C0 518
xref: PTHR10373:SF11
organism: Danio rerio

uniprot Q91XU7 911
type: UnificationXref
id: Q91XU7
db: uniprot

ISWI chromatin-remodeling complex ATPase ISW1
type: ProteinReference
xref: PTHR10799:SF856
xref: uniprot P38144 359
organism: Saccharomyces cerevisiae

Helicase (SNF2 family)
type: ProteinReference
xref: PTHR10799:SF987
xref: uniprot Q8TU84 422
organism: Methanosarcina acetivorans

uniprot Q9R100 951
type: UnificationXref
id: Q9R100
db: uniprot

uniprot F1MMW6 1381
type: UnificationXref
id: F1MMW6
db: uniprot

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

uniprot A0A0D1E0Y7 2043
type: UnificationXref
id: A0A0D1E0Y7
db: uniprot

uniprot F7ECA6 1446
type: UnificationXref
id: F7ECA6
db: uniprot

uniprot P51432 1113
type: UnificationXref
id: P51432
db: uniprot

Casein kinase 1 epsilon
type: ProteinReference
xref: uniprot Q5XGI6 1837
xref: PTHR11909:SF18
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF290
xref: uniprot F7BIQ7 748
organism: Monodelphis domestica

uniprot D4A3E3 272
type: UnificationXref
id: D4A3E3
db: uniprot

uniprot F7C1R7 751
type: UnificationXref
id: F7C1R7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF84
xref: uniprot F1PVD5 714
organism: Canis lupus familiaris

E3 ubiquitin-protein ligase siah-1
type: ProteinReference
xref: uniprot Q965X6 223
xref: PTHR45877:SF2
organism: Caenorhabditis elegans

uniprot K7DBC8 1408
type: UnificationXref
id: K7DBC8
db: uniprot

Protocadherin 7
type: ProteinReference
xref: PTHR24028:SF253
xref: uniprot A0A0A6YY83 619
organism: Mus musculus

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: uniprot C3XPR5 1144
xref: PTHR12027:SF101
organism: 7739

Diversin
type: ProteinReference
xref: P01466
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Diversin Synonym: Ankrd6 Accession: P01466
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Diversin
member entity reference: Ankyrin repeat domain-containing protein 6
member entity reference: Ankyrin repeat domain-containing protein 6 isoform a
member entity reference: ANKRD6 isoform 2
member entity reference: Ankrd6 protein

ncbitaxon 9258 98
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot Q9QXQ7 1279
type: UnificationXref
id: Q9QXQ7
db: uniprot

N-myc proto-oncogene protein
type: DnaReference
xref: PTHR45851:SF2
organism: 9031

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 1631
xref: PTHR19850:SF27
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 1630
xref: PTHR19850:SF29
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62872 1628
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62873 1629
organism: Homo sapiens

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

Secreted frizzled-related protein 3
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot P97401 1885
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 1632
xref: PTHR19850:SF27
organism: Mus musculus

uniprot Q15147 1116
type: UnificationXref
id: Q15147
db: uniprot

uniprot P20443 1579
type: UnificationXref
id: P20443
db: uniprot

uniprot P18537 118
type: UnificationXref
id: P18537
db: uniprot

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q6P647 1843
organism: Xenopus tropicalis

Protein Wnt
type: ProteinReference
xref: uniprot C3ZCG7 1149
xref: PTHR12027:SF102
organism: 7739

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Serine45 Beta Catenin s76 sa40 rs1
feature: Serine35 Beta Catenin s76 sa40 rs2
feature: serine33 Beta Catenin s76 sa40 rs3
feature: COMPLEX PARTICIPANT BINDING FEATURE s76 sa40 2230
feature: Threonine41 Beta Catenin s76 sa40 rs4
feature: Beta Catenin s76 sa40 rs5
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 272561 349
type: UnificationXref
id: 272561
db: ncbitaxon

uniprot Q9HCU4 942
type: UnificationXref
id: Q9HCU4
db: uniprot

NFAT s229 a495 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

uniprot P80202 1075
type: UnificationXref
id: P80202
db: uniprot

uniprot Q6P3K7 1842
type: UnificationXref
id: Q6P3K7
db: uniprot

uniprot F6XGB0 1181
type: UnificationXref
id: F6XGB0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62871 1627
organism: Bos taurus

uniprot A0A2I3TFS8 1489
type: UnificationXref
id: A0A2I3TFS8
db: uniprot

uniprot F1M6B6 696
type: UnificationXref
id: F1M6B6
db: uniprot

uniprot Q91398 1783
type: UnificationXref
id: Q91398
db: uniprot

uniprot F1Q0G6 1496
type: UnificationXref
id: F1Q0G6
db: uniprot

Smad4 s58 sa233 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smad4
stoichiometric coefficient: 1.0

ncbitaxon 39947 215
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot F1M7D0 698
type: UnificationXref
id: F1M7D0
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Wnt-RIGHT__Wnt-_re63
control type: INHIBITION
controller: FrzB

Galpha
type: Protein
entity reference: Galpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s156 sa75 2156
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P29829 1622
type: UnificationXref
id: P29829
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A4IFW0 1299
xref: PTHR45673:SF7
organism: Xenopus tropicalis

Galpha
type: Protein
entity reference: Galpha
feature: ACTIVE 50
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot E2RIL8 80
type: UnificationXref
id: E2RIL8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR15185:SF5
xref: uniprot F7EFL9 1435
organism: Monodelphis domestica

uniprot A5D7F4 660
type: UnificationXref
id: A5D7F4
db: uniprot

uniprot H2QD96 1203
type: UnificationXref
id: H2QD96
db: uniprot

uniprot F6PVT7 1607
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot F4K128 297
type: UnificationXref
id: F4K128
db: uniprot

uniprot Q9H1J7 1276
type: UnificationXref
id: Q9H1J7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 1600
xref: PTHR19850:SF25
organism: 7739

uniprot Q14571 40
type: UnificationXref
id: Q14571
db: uniprot

PTHR46102:SF1
type: RelationshipXref
id: PTHR46102:SF1
db: PANTHER Family
relationship type: By Homology

PTHR46102:SF2
type: RelationshipXref
id: PTHR46102:SF2
db: PANTHER Family
relationship type: By Homology

PTHR46102:SF3
type: RelationshipXref
id: PTHR46102:SF3
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5P6T7 623
type: UnificationXref
id: A0A1D5P6T7
db: uniprot

Mothers against decapentaplegic homolog 5
type: ProteinReference
xref: uniprot P97454 1547
xref: PTHR13703:SF36
organism: Mus musculus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot Q61151 585
organism: Mus musculus

uniprot H2R591 110
type: UnificationXref
id: H2R591
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F6WHM2 1179
xref: PTHR12027:SF72
organism: Monodelphis domestica

uniprot H2PZV0 1436
type: UnificationXref
id: H2PZV0
db: uniprot

uniprot Q02156 1694
type: UnificationXref
id: Q02156
db: uniprot

Frizzled-9
type: ProteinReference
xref: uniprot Q9R216 147
xref: PTHR11309:SF79
organism: Mus musculus

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

uniprot Q86WJ1 413
type: UnificationXref
id: Q86WJ1
db: uniprot

Pygo s99 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pygo
stoichiometric coefficient: 1.0

uniprot Q04727 487
type: UnificationXref
id: Q04727
db: uniprot

uniprot Q04724 484
type: UnificationXref
id: Q04724
db: uniprot

uniprot Q9FN19 1509
type: UnificationXref
id: Q9FN19
db: uniprot

plasma membrane
type: CellularLocationVocabulary
xref: GO GO:0005886 2

Pygo
type: Protein
entity reference: Pygo
feature: COMPLEX PARTICIPANT BINDING FEATURE s99 sa69 2162
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot G3V819 1197
type: UnificationXref
id: G3V819
db: uniprot

Casein Kinase 1
type: Protein
entity reference: Casein Kinase 1
feature: COMPLEX PARTICIPANT BINDING FEATURE s115 sa87 2384
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q08773 373
type: UnificationXref
id: Q08773
db: uniprot

uniprot P54311 1625
type: UnificationXref
id: P54311
db: uniprot

Cadherin 10
type: ProteinReference
xref: PTHR24027:SF290
xref: uniprot F1LR98 693
organism: Rattus norvegicus

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

uniprot F7FGS3 1524
type: UnificationXref
id: F7FGS3
db: uniprot

uniprot A3KMX5 69
type: UnificationXref
id: A3KMX5
db: uniprot

SWI/SNF
type: Protein
entity reference: SWI/SNF
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 sa67 2264
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot O76324 1813
type: UnificationXref
id: O76324
db: uniprot

uniprot H2QBE4 788
type: UnificationXref
id: H2QBE4
db: uniprot

uniprot D3ZNF4 1494
type: UnificationXref
id: D3ZNF4
db: uniprot

uniprot H2R1H5 158
type: UnificationXref
id: H2R1H5
db: uniprot

uniprot P63098 1337
type: UnificationXref
id: P63098
db: uniprot

uniprot P21461 209
type: UnificationXref
id: P21461
db: uniprot

uniprot Q90763 906
type: UnificationXref
id: Q90763
db: uniprot

uniprot K7CXU1 563
type: UnificationXref
id: K7CXU1
db: uniprot

Myosin, heavy chain a
type: DnaReference
xref: PTHR45615:SF44
organism: Danio rerio

uniprot P63100 1339
type: UnificationXref
id: P63100
db: uniprot

uniprot F6V461 1933
type: UnificationXref
id: F6V461
db: uniprot

uniprot F6TU68 1535
type: UnificationXref
id: F6TU68
db: uniprot

uniprot Q5B6M4 2087
type: UnificationXref
id: Q5B6M4
db: uniprot

Protocadherin Fat 3
type: ProteinReference
xref: uniprot Q8R508 898
xref: PTHR24026:SF49
organism: Rattus norvegicus

uniprot F6PMQ6 1173
type: UnificationXref
id: F6PMQ6
db: uniprot

CDH4 isoform 1
type: ProteinReference
xref: PTHR24027:SF81
xref: uniprot H2QKP9 790
organism: Pan troglodytes

Mothers against decapentaplegic homolog 4
type: ProteinReference
xref: uniprot P97471 1548
xref: PTHR13703:SF45
organism: Mus musculus

uniprot E1B969 670
type: UnificationXref
id: E1B969
db: uniprot

Pygo s96 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pygo
stoichiometric coefficient: 1.0

Protein Wnt-8c
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot P51030 1248
organism: 9031

uniprot P23625 1455
type: UnificationXref
id: P23625
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F1Q6Z7 545
xref: PTHR45619:SF42
organism: Danio rerio

PTHR11740:SF24
type: RelationshipXref
id: PTHR11740:SF24
db: PANTHER Family
relationship type: By Homology

PTHR11740:SF22
type: RelationshipXref
id: PTHR11740:SF22
db: PANTHER Family
relationship type: By Homology

uniprot Q00722 1114
type: UnificationXref
id: Q00722
db: uniprot

Cerberus
type: ProteinReference
xref: uniprot O55233 1291
xref: PTHR15273:SF4
organism: Mus musculus

PTHR11740:SF21
type: RelationshipXref
id: PTHR11740:SF21
db: PANTHER Family
relationship type: By Homology

PTHR11740:SF30
type: RelationshipXref
id: PTHR11740:SF30
db: PANTHER Family
relationship type: By Homology

Protein Wnt-8b
type: ProteinReference
xref: uniprot P51029 1247
xref: PTHR12027:SF94
organism: Danio rerio

alpha-Catenin
type: Protein
entity reference: alpha-Catenin
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein Wnt-8a
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot P51028 1246
organism: Danio rerio

uniprot Q7PQL1 878
type: UnificationXref
id: Q7PQL1
db: uniprot

uniprot P05128 1673
type: UnificationXref
id: P05128
db: uniprot

uniprot Q8TG11 1779
type: UnificationXref
id: Q8TG11
db: uniprot

uniprot Q12864 844
type: UnificationXref
id: Q12864
db: uniprot

DNA helicase, SNF2/RAD54 family
type: ProteinReference
xref: PTHR10799:SF923
xref: uniprot Q9RUX1 442
organism: Deinococcus radiodurans

Wnt inhibitor of Dorsal protein
type: ProteinReference
xref: uniprot Q9VFX1 1284
xref: PTHR12027:SF81
organism: Drosophila melanogaster

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot P41743 1689
organism: Homo sapiens

Casein kinase I isoform epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot F6R2T7 1798
organism: Macaca mulatta

uniprot E1BW98 1601
type: UnificationXref
id: E1BW98
db: uniprot

TGFbetaactivated Kinase-1
type: Protein
entity reference: TGFbetaactivated Kinase-1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

SWI/SNF complex subunit SMARCC1
type: ProteinReference
xref: PTHR12802:SF9
xref: uniprot P97496 371
organism: Mus musculus

Axin
type: Protein
entity reference: Axin
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa17 2324
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q62763 1840
type: UnificationXref
id: Q62763
db: uniprot

uniprot F7BUW7 1384
type: UnificationXref
id: F7BUW7
db: uniprot

uniprot Q8R5M2 1268
type: UnificationXref
id: Q8R5M2
db: uniprot

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 1999

uniprot P23298 1684
type: UnificationXref
id: P23298
db: uniprot

Protocadherin-12
type: ProteinReference
xref: PTHR24028:SF42
xref: uniprot Q9NPG4 943
organism: Homo sapiens

SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
type: ProteinReference
xref: uniprot E2REF0 281
xref: PTHR12802:SF9
organism: Canis lupus familiaris

DISSOCIATION_LEFT__Complex__Beta_Catenin_Cadherin_-RIGHT__Cadherin-_Beta_Catenin-_r101
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 2516
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 2515
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 2514
left: Complex (Beta-Catenin/Cadherin)
interaction type: DISSOCIATION
right: Beta-Catenin
right: Cadherin

uniprot P55281 826
type: UnificationXref
id: P55281
db: uniprot

uniprot P73089 839
type: UnificationXref
id: P73089
db: uniprot

uniprot P19454 1747
type: UnificationXref
id: P19454
db: uniprot

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q9DC28 1863
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r23 2517
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 2518
type: Stoichiometry
physical entity: a146 degraded s81 a148
stoichiometric coefficient: 1.0

Casein kinase I homolog hhp1
type: ProteinReference
xref: uniprot P40235 1822
xref: PTHR11909:SF18
organism: 284812

CSNK2A2 isoform 1
type: ProteinReference
xref: uniprot K7CVS9 1734
xref: PTHR24054:SF34
organism: Pan troglodytes

Casein kinase I homolog 2
type: ProteinReference
xref: uniprot P40234 1821
xref: PTHR11909:SF155
organism: 284812

PTHR11846:SF2
type: RelationshipXref
id: PTHR11846:SF2
db: PANTHER Family
relationship type: By Homology

Casein kinase I homolog hhp2
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot P40236 1823
organism: 284812

PTHR11846:SF0
type: RelationshipXref
id: PTHR11846:SF0
db: PANTHER Family
relationship type: By Homology

Cadherin-2 preproprotein
type: ProteinReference
xref: PTHR24027:SF79
xref: uniprot F6WI86 735
organism: Macaca mulatta

Transducin like enhancer of split 4
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot A0A3Q1LTE2 459
organism: Bos taurus

Frizzled-3
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot Q9NPG1 144
organism: Homo sapiens

Chromatin-remodeling ATPase INO80
type: ProteinReference
xref: PTHR45685:SF2
xref: uniprot Q8RXS6 420
organism: Arabidopsis thaliana

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot P40232 1755
xref: PTHR11740:SF0
organism: 284812

uniprot Q9Y5H6 998
type: UnificationXref
id: Q9Y5H6
db: uniprot

Casein kinase I homolog 1
type: ProteinReference
xref: uniprot P40233 1820
xref: PTHR11909:SF155
organism: 284812

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot P40231 1754
xref: PTHR24054:SF0
organism: 284812

uniprot Q8BKG4 134
type: UnificationXref
id: Q8BKG4
db: uniprot

uniprot F7GWD7 319
type: UnificationXref
id: F7GWD7
db: uniprot

BCL9, transcription coactivator
type: ProteinReference
xref: PTHR15185:SF5
xref: uniprot D4A7D6 1431
organism: Rattus norvegicus

uniprot Q9WV60 1027
type: UnificationXref
id: Q9WV60
db: uniprot

F-box/WD repeat-containing protein 11
type: ProteinReference
xref: PTHR44129:SF4
xref: uniprot Q5SRY7 1527
organism: Mus musculus

E3 ubiquitin-protein ligase SIAH2
type: ProteinReference
xref: uniprot Q8R4T2 219
organism: Rattus norvegicus

uniprot Q91XZ4 914
type: UnificationXref
id: Q91XZ4
db: uniprot

Casein kinase II subunit beta-2
type: ProteinReference
xref: uniprot P40229 1753
xref: PTHR11740:SF21
organism: Arabidopsis thaliana

Casein kinase II subunit beta-1
type: ProteinReference
xref: uniprot P40228 1752
xref: PTHR11740:SF0
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P1X4 18
xref: PTHR13715:SF53
organism: 9031

uniprot A0A2I3SBF9 253
type: UnificationXref
id: A0A2I3SBF9
db: uniprot

Arrestin, beta 2a
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot A0A286YBG8 1562
organism: Danio rerio

Histone deacetylase
type: Protein
entity reference: Histone deacetylase
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot E1B8Q3 1920
type: UnificationXref
id: E1B8Q3
db: uniprot

uniprot P49841 1022
type: UnificationXref
id: P49841
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot F6V7D9 548
organism: Canis lupus familiaris

uniprot F1MTG9 289
type: UnificationXref
id: F1MTG9
db: uniprot

uniprot Q9Y0A1 47
type: UnificationXref
id: Q9Y0A1
db: uniprot

ncbitaxon 214684 1322
type: UnificationXref
id: 214684
db: ncbitaxon

uniprot A0A1D5Q377 453
type: UnificationXref
id: A0A1D5Q377
db: uniprot

uniprot Q17QP5 1886
type: UnificationXref
id: Q17QP5
db: uniprot

Axin 2
type: DnaReference
xref: PTHR46102:SF1
organism: Pan troglodytes

uniprot Q5DRC4 854
type: UnificationXref
id: Q5DRC4
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot A0A1D5QG31 1439
xref: PTHR10218:SF328
organism: Macaca mulatta

Casein kinase II subunit alpha'
type: ProteinReference
xref: PTHR24054:SF34
xref: uniprot P19784 1748
organism: Homo sapiens

uniprot A0A1D5R803 1129
type: UnificationXref
id: A0A1D5R803
db: uniprot

Casein kinase-like protein
type: ProteinReference
xref: uniprot Q9LID3 1866
xref: PTHR11909:SF391
organism: Arabidopsis thaliana

AGAP005336-PA
type: ProteinReference
xref: PTHR13844:SF7
xref: uniprot Q7Q7F6 408
organism: Anopheles gambiae

Protein groucho
type: ProteinReference
xref: PTHR10814:SF21
xref: uniprot P16371 481
organism: Drosophila melanogaster

Dishevelled segment polarity protein 3
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot F6TYA8 1383
organism: Monodelphis domestica

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot A4D7S0 1136
organism: Bos taurus

uniprot P57077 1072
type: UnificationXref
id: P57077
db: uniprot

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform 2
type: ProteinReference
xref: uniprot F7H1V4 320
xref: PTHR13844:SF5
organism: Macaca mulatta

PTHR24054:SF47
type: RelationshipXref
id: PTHR24054:SF47
db: PANTHER Family
relationship type: By Homology

PTHR24054:SF46
type: RelationshipXref
id: PTHR24054:SF46
db: PANTHER Family
relationship type: By Homology

Casein kinase 2 alpha 2
type: ProteinReference
xref: PTHR24054:SF34
xref: uniprot F7F9Q9 1732
organism: 9258

PTHR24054:SF43
type: RelationshipXref
id: PTHR24054:SF43
db: PANTHER Family
relationship type: By Homology

Protocadherin 19
type: ProteinReference
xref: uniprot E2REK7 684
xref: PTHR24028:SF40
organism: Canis lupus familiaris

uniprot F6TID6 468
type: UnificationXref
id: F6TID6
db: uniprot

Serine35 Beta Catenin s184 sa100 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s184 sa100 rs2 Serine35
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 349

PTHR24054:SF0
type: RelationshipXref
id: PTHR24054:SF0
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6SSS3 1931
xref: PTHR13809:SF9
organism: Monodelphis domestica

uniprot H2Q1D9 1952
type: UnificationXref
id: H2Q1D9
db: uniprot

Beta Catenin s260 a561 rs5
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Fusobacterium nucleatum

PP2A s73 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

uniprot O60264 347
type: UnificationXref
id: O60264
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform
type: ProteinReference
xref: uniprot P78759 574
xref: PTHR10257:SF3
organism: 284812

Uncharacterized protein
type: ProteinReference
xref: uniprot E1B8D6 1401
xref: PTHR13808:SF29
organism: Bos taurus

PTHR24054:SF28
type: RelationshipXref
id: PTHR24054:SF28
db: PANTHER Family
relationship type: By Homology

PTHR24054:SF27
type: RelationshipXref
id: PTHR24054:SF27
db: PANTHER Family
relationship type: By Homology

AT26486p
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot Q9VYN5 1874
organism: Drosophila melanogaster

PTHR24054:SF34
type: RelationshipXref
id: PTHR24054:SF34
db: PANTHER Family
relationship type: By Homology

Ankyrin repeat domain-containing protein 6
type: ProteinReference
xref: uniprot Q9Y2G4 1995
xref: PTHR24203:SF7
organism: Homo sapiens

PTHR24054:SF35
type: RelationshipXref
id: PTHR24054:SF35
db: PANTHER Family
relationship type: By Homology

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot F7BIC2 1662
xref: PTHR24356:SF159
organism: Macaca mulatta

uniprot Q1RLX1 1080
type: UnificationXref
id: Q1RLX1
db: uniprot

uniprot Q9GZT5 1274
type: UnificationXref
id: Q9GZT5
db: uniprot

uniprot Q9I5D9 434
type: UnificationXref
id: Q9I5D9
db: uniprot

uniprot Q9W7C0 518
type: UnificationXref
id: Q9W7C0
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR11937:SF201
organism: Macaca mulatta

Serine35 Beta Catenin s260 a561 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s260 a561 rs2 Serine35
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

Protein Wnt
type: ProteinReference
xref: uniprot F7HEW6 1194
xref: PTHR12027:SF78
organism: Macaca mulatta

GO GO:0005886 2
type: UnificationXref
id: GO:0005886
db: GO

Protein Wnt
type: ProteinReference
xref: uniprot Q5TP56 1264
xref: PTHR12027:SF91
organism: Anopheles gambiae

Calcineurin
type: ProteinReference
xref: P01446
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Calcineurin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Calcineurin Synonym: Synonym not specified Accession: P01446
member entity reference: Protein phosphatase 2B
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
member entity reference: Uncharacterized protein
member entity reference: Q8LAS7
member entity reference: F7DKU1
member entity reference: Calcineurin B-like protein 3
member entity reference: Serine/threonine-protein phosphatase
member entity reference: Calcineurin B-like protein 10
member entity reference: A0A2I3RJ26
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit A2
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit
member entity reference: Calcineurin subunit B type 2
member entity reference: Protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b
member entity reference: Calcineurin subunit B
member entity reference: Calcineurin subunit B type 1
member entity reference: Calcineurin B-like protein 2
member entity reference: P63328
member entity reference: Calcineurin B-like protein 4
member entity reference: AGAP004298-PA
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit 2
member entity reference: Calcineurin B-like protein 1
member entity reference: Q9LTB8
member entity reference: Xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
member entity reference: Protein phospatase 3 regulatory subunit B alpha isoform type 1
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
member entity reference: P63329
member entity reference: E1C2T7
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit A1
member entity reference: Q24214
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit 1
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit 3
member entity reference: Calcineurin B subunit
member entity reference: Calcineurin B-like protein 7
member entity reference: Q96LZ3
member entity reference: Calcineurin B-like protein 5
member entity reference: Q9C5P6
member entity reference: Putative calcineurin B subunit

Beta Catenin s206 sa112 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

uniprot A4IIN1 200
type: UnificationXref
id: A4IIN1
db: uniprot

uniprot F6PWM3 86
type: UnificationXref
id: F6PWM3
db: uniprot

uniprot H2QJ36 1883
type: UnificationXref
id: H2QJ36
db: uniprot

Arrestin-C
type: ProteinReference
xref: uniprot P36575 1584
xref: PTHR11792:SF19
organism: Homo sapiens

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 1683
organism: Mus musculus

S-arrestin
type: ProteinReference
xref: PTHR11792:SF15
xref: uniprot P20443 1579
organism: Mus musculus

Endothelin-1
type: DnaReference
xref: PTHR13874:SF10
organism: Rattus norvegicus

Actin, alpha sarcomeric/skeletal
type: DnaReference
xref: PTHR11937:SF240
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MVN1 1520
xref: PTHR44156:SF2
organism: Bos taurus

Threonine41 Beta Catenin s193 sa108 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s193 sa108 rs4 Threonine41
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

Phosphoinositide phospholipase C (Fragment)
type: ProteinReference
xref: PTHR10336:SF149
xref: uniprot Q7PW25 1117
organism: Anopheles gambiae

uniprot P63003 483
type: UnificationXref
id: P63003
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot F6XII5 1937
organism: Monodelphis domestica

uniprot Q56IA0 1554
type: UnificationXref
id: Q56IA0
db: uniprot

Axin-2
type: ProteinReference
xref: uniprot P57095 166
xref: PTHR46102:SF1
organism: Danio rerio

Axin-1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot P57094 165
organism: Danio rerio

uniprot E1BF53 673
type: UnificationXref
id: E1BF53
db: uniprot

uniprot P35220 2030
type: UnificationXref
id: P35220
db: uniprot

Cadherin 4
type: ProteinReference
xref: PTHR24027:SF81
xref: uniprot F1MW29 706
organism: Bos taurus

uniprot Q7Q6D4 1641
type: UnificationXref
id: Q7Q6D4
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F5HMB9 1097
organism: Anopheles gambiae

Secreted frizzled-related protein 1
type: ProteinReference
xref: PTHR11309:SF87
xref: uniprot Q8N474 241
organism: Homo sapiens

uniprot F4JID0 1797
type: UnificationXref
id: F4JID0
db: uniprot

uniprot Q28GC2 196
type: UnificationXref
id: Q28GC2
db: uniprot

uniprot P40228 1752
type: UnificationXref
id: P40228
db: uniprot

uniprot Q8S1J0 1854
type: UnificationXref
id: Q8S1J0
db: uniprot

uniprot F2Z3T8 1929
type: UnificationXref
id: F2Z3T8
db: uniprot

ncbitaxon 208964 435
type: UnificationXref
id: 208964
db: ncbitaxon

Matrilysin
type: DnaReference
xref: PTHR10201:SF143
organism: Mus musculus

uniprot P08168 1572
type: UnificationXref
id: P08168
db: uniprot

uniprot Q9VAF5 964
type: UnificationXref
id: Q9VAF5
db: uniprot

Histone deacetylase 1
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot Q32PJ8 2084
organism: Bos taurus

Cadherin 13
type: ProteinReference
xref: PTHR24027:SF80
xref: uniprot Q8R490 897
organism: Rattus norvegicus

SWI/SNF and RSC complexes subunit ssr1
type: ProteinReference
xref: uniprot O13788 342
xref: PTHR12802:SF41
organism: 284812

uniprot F7HLC0 774
type: UnificationXref
id: F7HLC0
db: uniprot

uniprot D3ZF63 1151
type: UnificationXref
id: D3ZF63
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF77
xref: uniprot C3Z2P0 1148
organism: 7739

uniprot X1WEJ5 1288
type: UnificationXref
id: X1WEJ5
db: uniprot

MAP3K7 C-terminal-like protein
type: ProteinReference
xref: uniprot P57077 1072
organism: Homo sapiens

uniprot A2VDU3 1035
type: UnificationXref
id: A2VDU3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45685:SF2
xref: uniprot F6TFW8 303
organism: Monodelphis domestica

uniprot Q8K348 1085
type: UnificationXref
id: Q8K348
db: uniprot

Cadherin-1
type: ProteinReference
xref: uniprot Q9R0T4 950
xref: PTHR24027:SF319
organism: Rattus norvegicus

Cadherin-22
type: ProteinReference
xref: uniprot Q63315 871
xref: PTHR24027:SF311
organism: Rattus norvegicus

Transducin-like enhancer protein 4
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot Q07141 488
organism: Rattus norvegicus

Protocadherin beta 20
type: ProteinReference
xref: uniprot D4A7P5 667
xref: PTHR24028:SF81
organism: Rattus norvegicus

Protein kinase C
type: ProteinReference
xref: uniprot F1MDC9 1656
xref: PTHR24351:SF182
organism: Bos taurus

uniprot Q8IHZ9 1849
type: UnificationXref
id: Q8IHZ9
db: uniprot

uniprot P35508 1818
type: UnificationXref
id: P35508
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot F6YZA3 1939
organism: Monodelphis domestica

Ebi s131 sa116 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ebi
stoichiometric coefficient: 1.0

uniprot Q8RDV9 417
type: UnificationXref
id: Q8RDV9
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__SWI_SNF-_Complex__Bcl9_Beta_Catenin__TCF_Smad4__Pygo_-RIGHT__Complex__Beta_Catenin_TCF__Smad4_Bcl9__Pygo_SWI__SNF_-_r66
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 2447
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 2446
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 2448
left: Complex (Bcl9/Beta-Catenin/ TCF/Smad4/ Pygo)
left: SWI/SNF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Beta-Catenin/TCF/ Smad4/Bcl9/ Pygo/SWI/ SNF)

Frizzled-7
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot O75084 116
organism: Homo sapiens

uniprot G5EB64 2061
type: UnificationXref
id: G5EB64
db: uniprot

Protocadherin 7
type: ProteinReference
xref: uniprot A0A2I3SDT1 639
xref: PTHR24028:SF253
organism: Pan troglodytes

uniprot Q8LPI7 1851
type: UnificationXref
id: Q8LPI7
db: uniprot

Proto-oncogene Wnt-3
type: ProteinReference
xref: uniprot P17553 1224
xref: PTHR12027:SF82
organism: Mus musculus

T-box transcription factor T
type: DnaReference
xref: PTHR11267:SF83
organism: 9031

C-terminal binding protein 1
type: ProteinReference
xref: uniprot A0A3Q1M504 600
xref: PTHR46029:SF2
organism: Bos taurus

uniprot D3ZVU7 2049
type: UnificationXref
id: D3ZVU7
db: uniprot

Protein Wnt-2
type: ProteinReference
xref: uniprot P21552 1225
xref: PTHR12027:SF86
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6RE45 1423
xref: PTHR24055:SF380
organism: Monodelphis domestica

uniprot H2QEJ6 1542
type: UnificationXref
id: H2QEJ6
db: uniprot

PARTICIPANT STOICHIOMETRY r109 2481
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot F1MDE1 172
xref: PTHR24270:SF12
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r109 2480
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot F6TFY2 1932
organism: Macaca mulatta

uniprot A0A2I3RNK5 1788
type: UnificationXref
id: A0A2I3RNK5
db: uniprot

PARTICIPANT STOICHIOMETRY r108 2483
type: Stoichiometry
physical entity: Nemo-like Kinase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r108 2482
type: Stoichiometry
physical entity: Nemo-like Kinase
stoichiometric coefficient: 1.0

Threonine41 Beta Catenin s111 sa83 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s111 sa83 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

uniprot A0A2I3SIV3 641
type: UnificationXref
id: A0A2I3SIV3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MDX6 68
xref: PTHR11309:SF22
organism: Bos taurus

PTHR11909:SF297
type: RelationshipXref
id: PTHR11909:SF297
db: PANTHER Family
relationship type: By Homology

Axin s112 sa84 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

Calcineurin B-like protein 1
type: ProteinReference
xref: PTHR23056:SF44
xref: uniprot O81445 1320
organism: Arabidopsis thaliana

uniprot F6VHF7 21
type: UnificationXref
id: F6VHF7
db: uniprot

uniprot F1Q126 1796
type: UnificationXref
id: F1Q126
db: uniprot

Brahma-associated protein of 60 kDa
type: ProteinReference
xref: PTHR13844:SF7
xref: uniprot Q9VYG2 448
organism: Drosophila melanogaster

uniprot P43639 1756
type: UnificationXref
id: P43639
db: uniprot

uniprot H2QC24 1386
type: UnificationXref
id: H2QC24
db: uniprot

uniprot F7H415 1805
type: UnificationXref
id: F7H415
db: uniprot

uniprot Q9U9Y8 1429
type: UnificationXref
id: Q9U9Y8
db: uniprot

uniprot A4IFL6 1918
type: UnificationXref
id: A4IFL6
db: uniprot

uniprot F6XHP0 1936
type: UnificationXref
id: F6XHP0
db: uniprot

uniprot F7HPS8 776
type: UnificationXref
id: F7HPS8
db: uniprot

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s113 sa85 2380
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2J8NDG6 650
type: UnificationXref
id: A0A2J8NDG6
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 1612
xref: PTHR19850:SF28
organism: 9258

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BIA5 674
xref: PTHR24027:SF290
organism: Bos taurus

uniprot O00512 1437
type: UnificationXref
id: O00512
db: uniprot

Catenin beta-1
type: ProteinReference
xref: uniprot F1QGH7 187
xref: PTHR45976:SF4
organism: Danio rerio

Frizzled-9
type: ProteinReference
xref: uniprot O00144 112
xref: PTHR11309:SF79
organism: Homo sapiens

uniprot Q63315 871
type: UnificationXref
id: Q63315
db: uniprot

uniprot F6VWX1 2055
type: UnificationXref
id: F6VWX1
db: uniprot

Protocadherin beta-4
type: ProteinReference
xref: PTHR24028:SF55
xref: uniprot A0A2K6HNB9 652
organism: Pan troglodytes

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF203
xref: uniprot F6VWX1 2055
organism: Xenopus tropicalis

STATE_TRANSITION_LEFT__Complex__TCF_Smad4_-RIGHT__Complex__TCF_Smad4_-_re66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re66 2492
participant stoichiometry: PARTICIPANT STOICHIOMETRY re66 2491
left: Complex (TCF/Smad4)
interaction type: STATE_TRANSITION
right: Complex (TCF/Smad4)

uniprot P36894 1067
type: UnificationXref
id: P36894
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__IP3_Gated_Calcium_Channel-RIGHT__IP3_Gated_Calcium_Channel-_r77
controller: IP3

uniprot B7QGY5 534
type: UnificationXref
id: B7QGY5
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot C3XQF4 536
organism: 7739

Protein kinase C
type: ProteinReference
xref: uniprot F7BYI4 1663
xref: PTHR24356:SF158
organism: Macaca mulatta

uniprot F6TIF1 469
type: UnificationXref
id: F6TIF1
db: uniprot

ncbitaxon 178306 1999
type: UnificationXref
id: 178306
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot H2QJY5 1103
organism: Pan troglodytes

Myosin-1
type: DnaReference
xref: PTHR45615:SF3
organism: Bos taurus

Dapper homolog 1
type: ProteinReference
xref: uniprot Q8R4A3 2004
xref: PTHR15919:SF12
organism: Mus musculus

Kremen protein 2
type: ProteinReference
xref: uniprot Q8NCW0 1902
organism: Homo sapiens

Myosin-7
type: DnaReference
xref: PTHR45615:SF1
organism: Bos taurus

Pygo
type: Protein
entity reference: Pygo
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 sa66 2262
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9NQ66 1120
xref: PTHR10336:SF12
organism: Homo sapiens

Beta Catenin s128 sa114 rs5
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Myosin heavy chain 4
type: DnaReference
xref: PTHR45615:SF43
organism: Bos taurus

Myosin-1B
type: DnaReference
xref: PTHR45615:SF48
organism: 9031

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF273
xref: uniprot A0A1D5QZ34 631
organism: Macaca mulatta

PTHR45816:SF3
type: RelationshipXref
id: PTHR45816:SF3
db: PANTHER Family
relationship type: By Homology

E3 ubiquitin-protein ligase SIAH1
type: ProteinReference
xref: uniprot Q920M9 222
xref: PTHR45877:SF1
organism: Rattus norvegicus

Protein Wnt-7a
type: ProteinReference
xref: uniprot P24383 1231
xref: PTHR12027:SF78
organism: Mus musculus

Pygopus homolog 1
type: ProteinReference
xref: uniprot Q9Y3Y4 1917
xref: PTHR23194:SF3
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot C3ZBE3 1720
organism: 7739

uniprot F1PLB3 1096
type: UnificationXref
id: F1PLB3
db: uniprot

TCF s93 sa63 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Transcription factor 7-like 2
type: ProteinReference
xref: uniprot Q9NQB0 515
xref: PTHR10373:SF32
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Complex__TCF_Smad4_-RIGHT__Complex__TCF_Smad4_-_re66
control type: ACTIVATION
controller: Complex (Histone deacetylase/Transducin-like Enhance of Split 1-3)

Frizzled-9
type: ProteinReference
xref: uniprot Q8K4C8 136
xref: PTHR11309:SF79
organism: Rattus norvegicus

PTHR11909:SF323
type: RelationshipXref
id: PTHR11909:SF323
db: PANTHER Family
relationship type: By Homology

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot H2QLZ4 27
organism: Pan troglodytes

uniprot E2RGU7 1653
type: UnificationXref
id: E2RGU7
db: uniprot

PTHR11909:SF329
type: RelationshipXref
id: PTHR11909:SF329
db: PANTHER Family
relationship type: By Homology

Tumor necrosis factor
type: DnaReference
xref: PTHR11471:SF23
organism: Mus musculus

Chromodomain helicase DNA binding protein 1 like
type: ProteinReference
xref: uniprot A0A2I3S2B9 251
xref: PTHR47157:SF1
organism: Pan troglodytes

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot A1Z9D7 170
xref: PTHR46513:SF24
organism: Drosophila melanogaster

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot Q61011 1636
organism: Mus musculus

uniprot H2RA69 57
type: UnificationXref
id: H2RA69
db: uniprot

TCF s57 sa46 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A4ZGP0 1137
type: UnificationXref
id: A4ZGP0
db: uniprot

uniprot Q9LG11 1418
type: UnificationXref
id: Q9LG11
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot Q63269 46
xref: PTHR13715:SF51
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r74 2416
type: Stoichiometry
physical entity: Complex (G_Beta/Ggamma/ Galpha)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r74 2417
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Casein Kinase 2
type: Protein
entity reference: Casein Kinase 2
feature: COMPLEX PARTICIPANT BINDING FEATURE s151 sa136 2354
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r74 2415
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PTHR11909:SF316
type: RelationshipXref
id: PTHR11909:SF316
db: PANTHER Family
relationship type: By Homology

Arrestin-C
type: ProteinReference
xref: uniprot Q9EQP6 1592
xref: PTHR11792:SF19
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r74 2418
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r74 2419
type: Stoichiometry
physical entity: Complex (G_Beta/Ggamma)
stoichiometric coefficient: 1.0

uniprot Q91Y00 919
type: UnificationXref
id: Q91Y00
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A8X6D8 1303
xref: PTHR45673:SF1
organism: Caenorhabditis briggsae

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF36
xref: uniprot E2RCX7 1534
organism: Canis lupus familiaris

serine33 Beta Catenin s64 sa24 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s64 sa24 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

Serine45 Beta Catenin s138 sa123 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s138 sa123 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

Arrestin beta 2
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot E2QUH6 1565
organism: Canis lupus familiaris

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot F7ACT4 1015
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot A0A3Q2TVV5 1011
organism: 9031

uniprot Q9Y5H3 995
type: UnificationXref
id: Q9Y5H3
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot Q61016 1978
organism: Mus musculus

ncbitaxon 36329 352
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot F7BB02 1941
type: UnificationXref
id: F7BB02
db: uniprot

MYH3 protein
type: DnaReference
xref: PTHR45615:SF6
organism: Bos taurus

uniprot Q8BVP5 1847
type: UnificationXref
id: Q8BVP5
db: uniprot

Protein L-Myc
type: DnaReference
xref: PTHR45851:SF5
organism: Homo sapiens

uniprot F7GUW1 770
type: UnificationXref
id: F7GUW1
db: uniprot

N-myc proto-oncogene protein
type: DnaReference
xref: PTHR45851:SF2
organism: Homo sapiens

Myc proto-oncogene protein
type: DnaReference
xref: PTHR45851:SF1
organism: Homo sapiens

uniprot Q9Y5H2 994
type: UnificationXref
id: Q9Y5H2
db: uniprot

E3 ubiquitin-protein ligase sina
type: ProteinReference
xref: uniprot P21461 209
xref: PTHR45877:SF2
organism: Drosophila melanogaster

uniprot A0A2J8N8E6 67
type: UnificationXref
id: A0A2J8N8E6
db: uniprot

Myosin, heavy polypeptide 2, fast muscle-specific
type: DnaReference
xref: PTHR45615:SF44
organism: Danio rerio

PTHR46513:SF16
type: RelationshipXref
id: PTHR46513:SF16
db: PANTHER Family
relationship type: By Homology

Myosin-1
type: DnaReference
xref: PTHR45615:SF3
organism: Homo sapiens

Cadherin EGF LAG seven-pass G-type receptor 2
type: ProteinReference
xref: uniprot Q9R0M0 949
xref: PTHR24026:SF32
organism: Mus musculus

PTHR15185:SF5
type: RelationshipXref
id: PTHR15185:SF5
db: PANTHER Family
relationship type: By Homology

Beta Catenin s76 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

uniprot E2R9G5 1924
type: UnificationXref
id: E2R9G5
db: uniprot

uniprot F7DUC5 313
type: UnificationXref
id: F7DUC5
db: uniprot

Kurtz arrestin
type: ProteinReference
xref: uniprot Q9V393 1594
xref: PTHR11792:SF17
organism: Drosophila melanogaster

uniprot Q8N6Y1 895
type: UnificationXref
id: Q8N6Y1
db: uniprot

uniprot A0A2I3SYP1 1488
type: UnificationXref
id: A0A2I3SYP1
db: uniprot

Myosin-7
type: DnaReference
xref: PTHR45615:SF1
organism: Homo sapiens

Myosin-8
type: DnaReference
xref: PTHR45615:SF35
organism: Homo sapiens

serine33 Beta Catenin s128 sa114 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s128 sa114 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

uniprot Q7Q6D2 1639
type: UnificationXref
id: Q7Q6D2
db: uniprot

Myosin-6
type: DnaReference
xref: PTHR45615:SF11
organism: Homo sapiens

uniprot O70239 162
type: UnificationXref
id: O70239
db: uniprot

Protein Wnt-9a
type: ProteinReference
xref: uniprot Q8R5M2 1268
xref: PTHR12027:SF75
organism: Mus musculus

Myosin-3
type: DnaReference
xref: PTHR45615:SF6
organism: Homo sapiens

uniprot Q9QW07 1121
type: UnificationXref
id: Q9QW07
db: uniprot

Myosin-4
type: DnaReference
xref: PTHR45615:SF2
organism: Homo sapiens

Myosin-13
type: DnaReference
xref: PTHR45615:SF44
organism: Homo sapiens

Myosin-2
type: DnaReference
xref: PTHR45615:SF39
organism: Homo sapiens

uniprot A0A2I3RE49 633
type: UnificationXref
id: A0A2I3RE49
db: uniprot

Beta-Arrestin
type: Protein
entity reference: Beta-Arrestin
feature: COMPLEX PARTICIPANT BINDING FEATURE s152 sa137 2356
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Axin-1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot O15169 160
organism: Homo sapiens

Serine45 Beta Catenin s64 sa24 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s64 sa24 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

Uncharacterized protein
type: ProteinReference
xref: PTHR12533:SF11
xref: uniprot A0A1D5RJQ0 1471
organism: Macaca mulatta

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot F7E5M4 554
organism: 9258

uniprot F6XVN5 1521
type: UnificationXref
id: F6XVN5
db: uniprot

Bcl9
type: Protein
entity reference: Bcl9 PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 sa56 2272
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot E1C235 677
type: UnificationXref
id: E1C235
db: uniprot

Cadherin-17
type: ProteinReference
xref: PTHR24027:SF419
xref: uniprot Q9R100 951
organism: Mus musculus

uniprot Q9NRJ7 944
type: UnificationXref
id: Q9NRJ7
db: uniprot

uniprot Q91V48 908
type: UnificationXref
id: Q91V48
db: uniprot

Segment polarity protein dishevelled homolog DVL-3
type: ProteinReference
xref: uniprot Q61062 1396
xref: PTHR10878:SF6
organism: Mus musculus

uniprot O19116 236
type: UnificationXref
id: O19116
db: uniprot

uniprot F1PKX5 293
type: UnificationXref
id: F1PKX5
db: uniprot

uniprot Q8WMU5 138
type: UnificationXref
id: Q8WMU5
db: uniprot

uniprot F6ULG8 2053
type: UnificationXref
id: F6ULG8
db: uniprot

Protein Wnt-4a
type: ProteinReference
xref: uniprot P47793 1241
xref: PTHR12027:SF105
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot A4IGZ2 1919
organism: Xenopus tropicalis

Protein kinase superfamily protein
type: ProteinReference
xref: PTHR11909:SF356
xref: uniprot F4JID0 1797
organism: Arabidopsis thaliana

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot A7SG27 1711
organism: 45351

Secreted frizzled-related protein 5
type: ProteinReference
xref: PTHR11309:SF46
xref: uniprot Q9XSC1 246
organism: Bos taurus

uniprot Q9YH60 1028
type: UnificationXref
id: Q9YH60
db: uniprot

uniprot Q9Y5G6 989
type: UnificationXref
id: Q9Y5G6
db: uniprot

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s180 sa97 2112
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

MYCL proto-oncogene, bHLH transcription factor
type: DnaReference
xref: PTHR45851:SF5
organism: Rattus norvegicus

PTHR24057:SF0
type: RelationshipXref
id: PTHR24057:SF0
db: PANTHER Family
relationship type: By Homology

Cadherin-related family member 1
type: ProteinReference
xref: PTHR24028:SF263
xref: uniprot Q8WN91 903
organism: Bos taurus

uniprot O00744 1212
type: UnificationXref
id: O00744
db: uniprot

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

B-cell CLL/lymphoma 9 protein
type: ProteinReference
xref: PTHR15185:SF5
xref: uniprot Q9D219 1438
organism: Mus musculus

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot A0A3Q1N7P8 9
xref: PTHR45816:SF3
organism: Bos taurus

Beta Catenin s193 sa108 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta Catenin s193 sa108
stoichiometric coefficient: 1.0

PTHR24356:SF240
type: RelationshipXref
id: PTHR24356:SF240
db: PANTHER Family
relationship type: By Homology

PTHR12802:SF122
type: RelationshipXref
id: PTHR12802:SF122
db: PANTHER Family
relationship type: By Homology

uniprot P59768 1964
type: UnificationXref
id: P59768
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 10

Beta-transducin repeat containing E3 ubiquitin protein ligase
type: ProteinReference
xref: uniprot E2RDC4 1518
xref: PTHR44156:SF2
organism: Canis lupus familiaris

Probable ATP-dependent DNA helicase CHR12
type: ProteinReference
xref: PTHR10799:SF854
xref: uniprot F4J9M5 295
organism: Arabidopsis thaliana

Glycogen Synthase Kinase-3Beta
type: Protein
entity reference: Glycogen Synthase Kinase 3 Beta PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s186 sa102 2122
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 882

PARTICIPANT STOICHIOMETRY r45 2407
type: Stoichiometry
physical entity: Complex (Axin/PP2A)
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot P10894 1110
organism: Bos taurus

uniprot A8X9V3 269
type: UnificationXref
id: A8X9V3
db: uniprot

PARTICIPANT STOICHIOMETRY r45 2405
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 2406
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s124 sa92 2198
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Casein kinase 1-like protein 3
type: ProteinReference
xref: PTHR11909:SF97
xref: uniprot Q93Z18 1859
organism: Arabidopsis thaliana

RCG37051
type: ProteinReference
xref: uniprot F1LS01 694
xref: PTHR24028:SF248
organism: Rattus norvegicus

E1A binding protein p300
type: ProteinReference
xref: uniprot H2QLS0 1407
xref: PTHR13808:SF29
organism: Pan troglodytes

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: PTHR10878:SF5
xref: uniprot P51141 1391
organism: Mus musculus

Segment polarity protein dishevelled
type: ProteinReference
xref: PTHR10878:SF25
xref: uniprot P51140 1390
organism: Drosophila melanogaster

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: uniprot P97588 1549
xref: PTHR13703:SF23
organism: Rattus norvegicus

Cadherin-related family member 1
type: ProteinReference
xref: PTHR24028:SF263
xref: uniprot F1NKC9 708
organism: 9031

uniprot F7HKD3 1195
type: UnificationXref
id: F7HKD3
db: uniprot

Glycogen synthase kinase-3
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot P51136 1023
organism: Dictyostelium discoideum

PTHR24356:SF214
type: RelationshipXref
id: PTHR24356:SF214
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot F1MEW8 1166
organism: Bos taurus

Diversin s68 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Diversin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SRK5 188
xref: PTHR45976:SF4
organism: Monodelphis domestica

uniprot F7CAF6 311
type: UnificationXref
id: F7CAF6
db: uniprot

uniprot A0A2I3T0A7 255
type: UnificationXref
id: A0A2I3T0A7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12656:SF11
xref: uniprot F6WZ81 307
organism: 9258

Cadherin EGF LAG seven-pass G-type receptor 2
type: ProteinReference
xref: PTHR24026:SF32
xref: uniprot Q9HCU4 942
organism: Homo sapiens

PTHR46513:SF24
type: RelationshipXref
id: PTHR46513:SF24
db: PANTHER Family
relationship type: By Homology

uniprot D3ZND6 1153
type: UnificationXref
id: D3ZND6
db: uniprot

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: PTHR10878:SF5
xref: uniprot Q5IS48 1394
organism: Pan troglodytes

HETERODIMER_ASSOCIATION_LEFT__Complex__Ebi_Siah_1_-_Complex__Adenomatous_Polyposis_Coli_Axin__Beta_Catenin_PP2A_-RIGHT__Complex__Adenomatous_Polyposis_Coli_Axin__PP2A_Beta_Catenin__Siah_1_Ebi_-_r54
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 2524
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 2523
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 2522
left: Complex Adenomatous Polyposis Coli Axin Beta Catenin PP2A s123 a275
left: Complex (Ebi/Siah-1)
interaction type: HETERODIMER_ASSOCIATION
right: Complex Adenomatous Polyposis Coli Axin PP2A Beta Catenin Siah 1 Ebi s159 a368

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F1MD32 1402
organism: Bos taurus

uniprot F6WUH3 1498
type: UnificationXref
id: F6WUH3
db: uniprot

SWI/SNF nucleosome remodeling complex component
type: ProteinReference
xref: PTHR46232:SF1
xref: uniprot Q9BL39 431
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF273
xref: uniprot F7EXZ6 762
organism: Monodelphis domestica

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Thermotoga maritima

Axin 1
type: DnaReference
xref: PTHR46102:SF3
organism: Pan troglodytes

uniprot F7ABP2 745
type: UnificationXref
id: F7ABP2
db: uniprot

Catenin alpha 3
type: ProteinReference
xref: PTHR18914:SF21
xref: uniprot G3N018 2022
organism: Bos taurus

uniprot B0JYL0 1533
type: UnificationXref
id: B0JYL0
db: uniprot

Cadherin-11
type: ProteinReference
xref: uniprot A0A1D5P6T7 623
xref: PTHR24027:SF85
organism: 9031

uniprot Q9DAS9 1984
type: UnificationXref
id: Q9DAS9
db: uniprot

ncbitaxon 5786 1310
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot Q6ZPV2 403
type: UnificationXref
id: Q6ZPV2
db: uniprot

uniprot O14470 343
type: UnificationXref
id: O14470
db: uniprot

Armadillo segment polarity protein
type: ProteinReference
xref: uniprot P18824 192
organism: Drosophila melanogaster

Protocadherin-8
type: ProteinReference
xref: PTHR24028:SF46
xref: uniprot O95206 811
organism: Homo sapiens

uniprot F7CCD5 1051
type: UnificationXref
id: F7CCD5
db: uniprot

Frizzled-8
type: ProteinReference
xref: PTHR11309:SF90
xref: uniprot Q9H461 140
organism: Homo sapiens

uniprot A0A0G2K8I5 621
type: UnificationXref
id: A0A0G2K8I5
db: uniprot

Serine35 Beta Catenin s64 sa24 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s64 sa24 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

uniprot Q6ZRS2 404
type: UnificationXref
id: Q6ZRS2
db: uniprot

serine33 Beta Catenin s82 sa52 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s82 sa52 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

Uncharacterized protein
type: ProteinReference
xref: PTHR46029:SF2
xref: uniprot A0A1D5P770 598
organism: 9031

Helicase of the snf2/rad54 family
type: ProteinReference
xref: uniprot P74552 368
xref: PTHR10799:SF987
organism: Synechocystis

Calcineurin subunit B
type: ProteinReference
xref: uniprot P0CM54 1321
xref: PTHR45942:SF1
organism: 214684

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F6XHP0 1936
organism: Macaca mulatta

ncbitaxon 8364 22
type: UnificationXref
id: 8364
db: ncbitaxon

Actin, gamma 2, smooth muscle, enteric
type: DnaReference
xref: PTHR11937:SF445
organism: Canis lupus familiaris

Frizzled class receptor 8b
type: ProteinReference
xref: PTHR11309:SF140
xref: uniprot B0S6S2 74
organism: Danio rerio

uniprot Q7QDI9 2037
type: UnificationXref
id: Q7QDI9
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F7H4T8 1054
organism: Macaca mulatta

Axin
type: Protein
entity reference: Axin
feature: COMPLEX PARTICIPANT BINDING FEATURE s122 sa91 2196
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protocadherin beta 14
type: ProteinReference
xref: PTHR24028:SF139
xref: uniprot D3ZM08 664
organism: Rattus norvegicus

PTHR12802:SF105
type: RelationshipXref
id: PTHR12802:SF105
db: PANTHER Family
relationship type: By Homology

uniprot A0A0D1CEH3 2041
type: UnificationXref
id: A0A0D1CEH3
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 215

uniprot B8JMI2 1376
type: UnificationXref
id: B8JMI2
db: uniprot

uniprot Q498S8 123
type: UnificationXref
id: Q498S8
db: uniprot

uniprot O02482 478
type: UnificationXref
id: O02482
db: uniprot

uniprot Q64527 1265
type: UnificationXref
id: Q64527
db: uniprot

uniprot F1N5R1 1170
type: UnificationXref
id: F1N5R1
db: uniprot

uniprot A0A1D5QLH3 1030
type: UnificationXref
id: A0A1D5QLH3
db: uniprot

uniprot P10687 1109
type: UnificationXref
id: P10687
db: uniprot

Complex (Wnt/Frizzled)
type: Complex
component stoichiometry: Wnt s3 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Frizzled s4 sa2 STOICHIOMETRY ID COMPLEX
component: Wnt s3 sa1
component: Frizzled
feature: COMPLEX BINDING FEATURE s16 a16 2185
feature: ACTIVE 50
feature: COMPLEX BINDING FEATURE s16 a16 2187
cellular location: plasma membrane

uniprot Q7PD38 590
type: UnificationXref
id: Q7PD38
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot P28867 1686
xref: PTHR24356:SF365
organism: Mus musculus

Protein CBR-EGL-20
type: ProteinReference
xref: PTHR12027:SF70
xref: uniprot A8WV58 1140
organism: Caenorhabditis briggsae

uniprot F7A659 95
type: UnificationXref
id: F7A659
db: uniprot

uniprot O00144 112
type: UnificationXref
id: O00144
db: uniprot

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot P42168 1824
organism: Caenorhabditis elegans

Kremen protein
type: ProteinReference
xref: uniprot F1PCF1 1898
organism: Canis lupus familiaris

uniprot O17695 2068
type: UnificationXref
id: O17695
db: uniprot

uniprot Q96287 1025
type: UnificationXref
id: Q96287
db: uniprot

serine33 Beta Catenin s111 sa83 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s111 sa83 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot A0A1D5QFE1 1128
organism: Macaca mulatta

uniprot Q9HC56 940
type: UnificationXref
id: Q9HC56
db: uniprot

Cadherin 22
type: ProteinReference
xref: uniprot A0A3Q1MCN6 657
xref: PTHR24027:SF311
organism: Bos taurus

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot Q4QCE7 2086
organism: Leishmania major

uniprot P13217 1111
type: UnificationXref
id: P13217
db: uniprot

uniprot A0A1D5QHP7 1560
type: UnificationXref
id: A0A1D5QHP7
db: uniprot

uniprot P62880 1632
type: UnificationXref
id: P62880
db: uniprot

uniprot Q9ZUP4 1876
type: UnificationXref
id: Q9ZUP4
db: uniprot

uniprot Q9HBT6 939
type: UnificationXref
id: Q9HBT6
db: uniprot

Threonine41 Beta Catenin s76 sa40 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s76 sa40 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

Threonine41 Beta Catenin s232 a380 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s232 a380 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

uniprot Q5XGI6 1837
type: UnificationXref
id: Q5XGI6
db: uniprot

Serine35 Beta Catenin s92 sa62 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s92 sa62 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

uniprot Q62761 1838
type: UnificationXref
id: Q62761
db: uniprot

uniprot Q08464 120
type: UnificationXref
id: Q08464
db: uniprot

uniprot Q91Y07 925
type: UnificationXref
id: Q91Y07
db: uniprot

Cadherin 12
type: ProteinReference
xref: uniprot E2R790 681
xref: PTHR24027:SF96
organism: Canis lupus familiaris

uniprot E2RGI5 1925
type: UnificationXref
id: E2RGI5
db: uniprot

uniprot F1PS63 1046
type: UnificationXref
id: F1PS63
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot F7EZ48 100
organism: Macaca mulatta

Histone deacetylase
type: ProteinReference
xref: uniprot E2R792 2050
xref: PTHR10625:SF201
organism: Canis lupus familiaris

uniprot P14747 1323
type: UnificationXref
id: P14747
db: uniprot

Histone deacetylase
type: ProteinReference
xref: uniprot F7FJQ1 2060
xref: PTHR10625:SF203
organism: 9258

uniprot F6TED2 203
type: UnificationXref
id: F6TED2
db: uniprot

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Beta Catenin s111 sa83 rs5
feature: Serine35 Beta Catenin s111 sa83 rs2
feature: serine33 Beta Catenin s111 sa83 rs3
feature: COMPLEX PARTICIPANT BINDING FEATURE s111 sa83 2376
feature: Serine45 Beta Catenin s111 sa83 rs1
feature: Threonine41 Beta Catenin s111 sa83 rs4
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein Kinase C
type: ProteinReference
xref: P01458
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Protein Kinase C
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein Kinase C Synonym: PKC Accession: P01458
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C iota type
member entity reference: Protein kinase C
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C eta type
member entity reference: Protein kinase C beta type
member entity reference: P63319
member entity reference: P05129
member entity reference: Protein kinase C delta type
member entity reference: Q5PU49
member entity reference: Protein kinase C theta type
member entity reference: P05130
member entity reference: P05126
member entity reference: Protein kinase C-like 1B
member entity reference: P34722
member entity reference: Protein kinase C zeta type
member entity reference: E2RNP2
member entity reference: Protein kinase C-like 3
member entity reference: E1BQN6
member entity reference: P05128
member entity reference: Q7Q042
member entity reference: Protein kinase C, eye isozyme
member entity reference: P63318
member entity reference: Q02111
member entity reference: Q02156

Helicase swr1
type: ProteinReference
xref: PTHR45685:SF1
xref: uniprot O13682 340
organism: 284812

Casein Kinase 1
type: ProteinReference
xref: P01460
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Casein Kinase 1 Synonym: CK1 Accession: P01460
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Casein Kinase 1
member entity reference: F7AM42
member entity reference: P67827
member entity reference: Casein kinase 1, alpha 1
member entity reference: Casein kinase 1-like protein 2
member entity reference: Casein kinase I isoform delta-A
member entity reference: Casein kinase I isoform alpha
member entity reference: Casein kinase-like protein
member entity reference: Casein kinase I isoform delta
member entity reference: Os01g0570500 protein
member entity reference: Q9LSX4
member entity reference: Casein kinase I gamma
member entity reference: Uncharacterized protein
member entity reference: Casein kinase I isoform gamma-3
member entity reference: Casein kinase I homolog HRR25
member entity reference: CSNK1A1L isoform 1
member entity reference: CSNK1G2 protein
member entity reference: Casein kinase 1 delta
member entity reference: Casein kinase I
member entity reference: Casein kinase 1-like protein 6
member entity reference: Casein kinase I isoform gamma-2
member entity reference: Casein kinase I isoform epsilon
member entity reference: Q9NHE2
member entity reference: Casein kinase I homolog 3
member entity reference: Casein kinase 1-like protein 7
member entity reference: AT15039p
member entity reference: Casein kinase 1 alpha 1
member entity reference: Casein kinase I homolog hhp1
member entity reference: P67962
member entity reference: Casein kinase I homolog 2
member entity reference: A0A2I3RHK0
member entity reference: Protein CBR-KIN-19
member entity reference: CSNK1D isoform 8
member entity reference: Q8S1J0
member entity reference: F6VPH2
member entity reference: Casein kinase I isoform delta-B
member entity reference: Casein kinase I homolog hhp2
member entity reference: Casein kinase I isoform alpha-like
member entity reference: Serine/threonine-protein kinase spe-6
member entity reference: Casein kinase 1 gamma 2
member entity reference: Predicted protein
member entity reference: Protein kinase superfamily protein
member entity reference: Casein kinase I isoform gamma-1
member entity reference: Casein kinase 1 gamma 3
member entity reference: Casein kinase I homolog 1
member entity reference: Casein kinase 1-like protein 13
member entity reference: Q06486
member entity reference: Putative casein kinase I
member entity reference: Protein kinase family protein
member entity reference: Tau TuBulin Kinase
member entity reference: Discs overgrown protein kinase
member entity reference: Q9VQE3
member entity reference: Casein kinase 1-like protein 10
member entity reference: CSNK1G3 isoform 8
member entity reference: AT26486p
member entity reference: Casein kinase 1-like protein 5
member entity reference: FI08417p
member entity reference: Casein kinase I isoform beta
member entity reference: Q99PS2

Threonine41 Beta Catenin s260 a561 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s260 a561 rs4 Threonine41
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

uniprot A0A2I3RQJ8 1645
type: UnificationXref
id: A0A2I3RQJ8
db: uniprot

Histone deacetylase
type: ProteinReference
xref: uniprot Q7PX00 2093
xref: PTHR10625:SF201
organism: Anopheles gambiae

uniprot F7ESJ0 232
type: UnificationXref
id: F7ESJ0
db: uniprot

ISWI chromatin-remodeling complex ATPase ISW2
type: ProteinReference
xref: uniprot Q08773 373
xref: PTHR10799:SF879
organism: Saccharomyces cerevisiae

Homeobox protein engrailed-2b
type: DnaReference
xref: PTHR24341:SF5
organism: Danio rerio

uniprot F1PPY7 2015
type: UnificationXref
id: F1PPY7
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__Dishevelled_Beta_Arrestin__Frodo_Casein_Kinase_2_-_FRAT-RIGHT__Complex__Dishevelled_Casein_Kinase_2__Beta_Arrestin_Frodo__FRAT_-_r103
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 2502
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 2501
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 2503
left: Complex (Dishevelled/Beta-Arrestin/ Frodo/Casein Kinase 2)
left: FRAT
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Dishevelled/Casein Kinase 2/ Beta-Arrestin/Frodo/ FRAT)

Casein Kinase 1
type: Protein
entity reference: Casein Kinase 1
feature: COMPLEX PARTICIPANT BINDING FEATURE s182 sa99 2116
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Cadherin-7
type: ProteinReference
xref: PTHR24027:SF91
xref: uniprot Q5DWV2 868
organism: Rattus norvegicus

NFAT Target Genes
type: DnaRegionReference
member entity reference: Actin, alpha skeletal muscle
member entity reference: Ensembl ENSCING00000001377
member entity reference: Tumor necrosis factor
member entity reference: Adenylosuccinate synthetase isozyme 1
member entity reference: Adenylosuccinate synthetase
member entity reference: RGD_62030
member entity reference: Actin, alpha 2, smooth muscle, aorta
member entity reference: Actin alpha 2, smooth muscle
member entity reference: Actin, alpha, cardiac muscle 1
member entity reference: Gene ACTG2
member entity reference: MGI MGI:1339711
member entity reference: MGI MGI:1339710
member entity reference: Gene ACTC1
member entity reference: Endothelin-1
member entity reference: Ensembl ENSMMUG00000009771
member entity reference: Adenylosuccinate synthetase isozyme 2
member entity reference: Myosin heavy chain 6
member entity reference: ZFIN ZDB-GENE-030131-6206
member entity reference: MYH4 isoform 1
member entity reference: MGI MGI:1339712
member entity reference: Actin, gamma-enteric smooth muscle
member entity reference: EnsemblGenome PAE0974
member entity reference: Myosin, heavy polypeptide 2, fast muscle-specific
member entity reference: Actin, cytoplasmic type 5
member entity reference: Ensembl ENSMMUG00000014762
member entity reference: Actin, alpha cardiac muscle 2
member entity reference: Actin alpha 1, skeletal muscle a
member entity reference: Myosin-4
member entity reference: Myosin, heavy chain a
member entity reference: EnsemblGenome DR 0035
member entity reference: ACTA1 isoform 1
member entity reference: Ensembl ENSMMUG00000009763
member entity reference: Developmental myosin heavy chain embryonic
member entity reference: Ensembl ENSMMUG00000009759
member entity reference: Myosin-6
member entity reference: Actin, alpha cardiac muscle 1
member entity reference: Myosin-8
member entity reference: HGNC_20093
member entity reference: MGI MGI:1339713
member entity reference: Myosin-13
member entity reference: Adenylosuccinate synthetase 2
member entity reference: Endothelin 1
member entity reference: Myosin-2
member entity reference: Uncharacterized protein
member entity reference: RGD_1310508
member entity reference: Ensembl ENSGALG00000028749
member entity reference: Myosin-3
member entity reference: Myosin-7B
member entity reference: ZFIN ZDB-GENE-040625-35
member entity reference: EnsemblGenome MA 1919
member entity reference: Gene BRAFLDRAFT 115565
member entity reference: Actin alpha cardiac muscle 1b
member entity reference: Myosin-7

Axin
type: Protein
entity reference: Axin
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa23 2146
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Cadherin-20
type: ProteinReference
xref: PTHR24027:SF84
xref: uniprot Q5DWV1 867
organism: Rattus norvegicus

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF45
xref: uniprot F7A1M2 1538
organism: Monodelphis domestica

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F1PV54 544
xref: PTHR10257:SF4
organism: Canis lupus familiaris

Protein CBR-CWN-2
type: ProteinReference
xref: PTHR12027:SF77
xref: uniprot A8WV10 1139
organism: Caenorhabditis briggsae

Cadherin 18
type: ProteinReference
xref: PTHR24027:SF106
xref: uniprot F6VFP8 732
organism: 9258

FAT atypical cadherin 1
type: ProteinReference
xref: uniprot A0A2I3RPI4 636
xref: PTHR24026:SF42
organism: Pan troglodytes

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot P35508 1818
organism: Bos taurus

Dishevelled
type: Protein
entity reference: Dishevelled
feature: COMPLEX PARTICIPANT BINDING FEATURE s143 sa128 2334
feature: Dishevelled s143 sa128 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Casein kinase I isoform beta
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot P35507 1817
organism: Bos taurus

Adenylosuccinate synthetase, chloroplastic
type: DnaReference
xref: PTHR11846:SF0
organism: Arabidopsis thaliana

uniprot P58365 836
type: UnificationXref
id: P58365
db: uniprot

uniprot F6S406 2016
type: UnificationXref
id: F6S406
db: uniprot

uniprot A0A2J8MVE2 648
type: UnificationXref
id: A0A2J8MVE2
db: uniprot

uniprot F7G755 555
type: UnificationXref
id: F7G755
db: uniprot

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot P16298 1324
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot H2RAM0 1207
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot A0A1D5NUC4 1029
organism: 9031

Calcineurin B subunit
type: ProteinReference
xref: uniprot A7E4J2 1301
xref: PTHR45942:SF1
organism: Sclerotinia sclerotiorum

Adenomatous Polyposis Coli s52 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F1MX21 17
xref: PTHR13715:SF52
organism: Bos taurus

uniprot O22446 2069
type: UnificationXref
id: O22446
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F7FK62 1190
xref: PTHR12027:SF94
organism: 9258

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1MCE7 1040
organism: Bos taurus

PTHR23056:SF96
type: RelationshipXref
id: PTHR23056:SF96
db: PANTHER Family
relationship type: By Homology

PTHR23056:SF90
type: RelationshipXref
id: PTHR23056:SF90
db: PANTHER Family
relationship type: By Homology

Tumor necrosis factor
type: DnaReference
xref: PTHR11471:SF23
organism: Macaca mulatta

AGAP008871-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PWS3 132
xref: PTHR11309:SF23
organism: Anopheles gambiae

Complex (Siah-1/Ebi)
type: Complex
component stoichiometry: Ebi s22 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Siah 1 s20 sa10 STOICHIOMETRY ID COMPLEX
component: Siah 1 s20 sa10
component: Ebi s22 sa11
feature: COMPLEX BINDING FEATURE s101 a205 2235
feature: COMPLEX BINDING FEATURE s101 a205 2237
cellular location: plasma membrane

uniprot F1MLM2 288
type: UnificationXref
id: F1MLM2
db: uniprot

PTHR10913:SF13
type: RelationshipXref
id: PTHR10913:SF13
db: PANTHER Family
relationship type: By Homology

Protein Wnt-5b
type: ProteinReference
xref: uniprot Q92050 1270
xref: PTHR12027:SF87
organism: Danio rerio

uniprot P18334 1745
type: UnificationXref
id: P18334
db: uniprot

uniprot A0A1D5Q7V1 1531
type: UnificationXref
id: A0A1D5Q7V1
db: uniprot

Actin, alpha 2, smooth muscle, aorta
type: DnaReference
xref: PTHR11937:SF445
organism: Xenopus tropicalis

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F7EDR2 1052
organism: 9258

Protein Wnt
type: ProteinReference
xref: uniprot E2RDT2 1163
xref: PTHR12027:SF94
organism: Canis lupus familiaris

Secreted frizzled-related protein 1
type: ProteinReference
xref: PTHR11309:SF87
xref: uniprot Q8C4U3 240
organism: Mus musculus

Frizzled-4
type: ProteinReference
xref: uniprot Q61088 126
xref: PTHR11309:SF23
organism: Mus musculus

Frizzled-6
type: ProteinReference
xref: PTHR11309:SF75
xref: uniprot Q61089 127
organism: Mus musculus

Protein Wnt-2
type: ProteinReference
xref: uniprot Q92048 1269
xref: PTHR12027:SF86
organism: Danio rerio

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform a
type: ProteinReference
xref: PTHR13844:SF1
xref: uniprot F7HTY2 321
organism: Macaca mulatta

uniprot F1MD32 1402
type: UnificationXref
id: F1MD32
db: uniprot

Frizzled-3
type: ProteinReference
xref: uniprot Q61086 125
xref: PTHR11309:SF22
organism: Mus musculus

Shaggy-related protein kinase gamma
type: ProteinReference
xref: uniprot P43289 1021
organism: Arabidopsis thaliana

Shaggy-related protein kinase alpha
type: ProteinReference
xref: uniprot P43288 1020
organism: Arabidopsis thaliana

PTHR24341:SF4
type: RelationshipXref
id: PTHR24341:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q5RJH3 870
type: UnificationXref
id: Q5RJH3
db: uniprot

PTHR24341:SF5
type: RelationshipXref
id: PTHR24341:SF5
db: PANTHER Family
relationship type: By Homology

PTHR24341:SF6
type: RelationshipXref
id: PTHR24341:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q99MH6 61
type: UnificationXref
id: Q99MH6
db: uniprot

PTHR24341:SF7
type: RelationshipXref
id: PTHR24341:SF7
db: PANTHER Family
relationship type: By Homology

C-terminal-binding protein 1 isoform 1
type: ProteinReference
xref: uniprot F7HTZ1 607
xref: PTHR46029:SF2
organism: Macaca mulatta

Serine/threonine-protein phosphatase 2B catalytic subunit 3
type: ProteinReference
xref: uniprot Q9VXF1 1373
xref: PTHR45673:SF1
organism: Drosophila melanogaster

Secreted frizzled-related protein 5
type: ProteinReference
xref: PTHR11309:SF46
xref: uniprot Q5T4F7 239
organism: Homo sapiens

PTHR11909:SF388
type: RelationshipXref
id: PTHR11909:SF388
db: PANTHER Family
relationship type: By Homology

Casein kinase I isoform delta-A
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q7T2E3 1845
organism: Danio rerio

Low-density lipoprotein receptor-related protein 5
type: ProteinReference
xref: uniprot O75197 180
xref: PTHR46513:SF16
organism: Homo sapiens

Adenomatous Polyposis Coli s44 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli
stoichiometric coefficient: 1.0

uniprot Q9SQR8 1871
type: UnificationXref
id: Q9SQR8
db: uniprot

PTHR11909:SF391
type: RelationshipXref
id: PTHR11909:SF391
db: PANTHER Family
relationship type: By Homology

uniprot Q28FH0 1463
type: UnificationXref
id: Q28FH0
db: uniprot

PTHR11909:SF395
type: RelationshipXref
id: PTHR11909:SF395
db: PANTHER Family
relationship type: By Homology

uniprot Q75NI5 875
type: UnificationXref
id: Q75NI5
db: uniprot

uniprot P78759 574
type: UnificationXref
id: P78759
db: uniprot

PTHR10373:SF25
type: RelationshipXref
id: PTHR10373:SF25
db: PANTHER Family
relationship type: By Homology

uniprot Q8VE28 58
type: UnificationXref
id: Q8VE28
db: uniprot

uniprot F6V5F4 93
type: UnificationXref
id: F6V5F4
db: uniprot

C-terminal-binding protein 2
type: ProteinReference
xref: PTHR46029:SF3
xref: uniprot Q9EQH5 617
organism: Rattus norvegicus

PTHR23056:SF44
type: RelationshipXref
id: PTHR23056:SF44
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot A0A1D5RL09 525
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r60 2473
type: Stoichiometry
physical entity: Complex (Histone deacetylase/Transducin-like Enhance of Split 1-3)
stoichiometric coefficient: 1.0

uniprot P54509 366
type: UnificationXref
id: P54509
db: uniprot

PTHR10373:SF11
type: RelationshipXref
id: PTHR10373:SF11
db: PANTHER Family
relationship type: By Homology

Frizzled-8
type: ProteinReference
xref: PTHR11309:SF90
xref: uniprot Q61091 129
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r60 2472
type: Stoichiometry
physical entity: Transducin-like Enhance of Split 1-3
stoichiometric coefficient: 1.0

Frizzled-7
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot Q61090 128
organism: Mus musculus

CBP
type: Protein
entity reference: CBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s105 sa72 2168
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r60 2471
type: Stoichiometry
physical entity: Histone deacetylase
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A0A2I3SD30 1298
xref: PTHR45673:SF2
organism: Pan troglodytes

uniprot F7HPU3 777
type: UnificationXref
id: F7HPU3
db: uniprot

uniprot H2Q2Q9 608
type: UnificationXref
id: H2Q2Q9
db: uniprot

Beta-Catenin
type: ProteinReference
xref: P01432
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC._Beta_-Catenin
comment: ENTITY_REFERENCE_NOTES= Long Name: Beta-Catenin Synonym: Armadillo Accession: P01432
member entity reference: Catenin beta-1
member entity reference: Armadillo segment polarity protein
member entity reference: Q02248
member entity reference: Catenin (Cadherin-associated protein), beta 1, 88kDa
member entity reference: Uncharacterized protein
member entity reference: F6WBD5
member entity reference: Catenin, beta 2
member entity reference: CTNNB1 isoform 2

PTHR11909:SF367
type: RelationshipXref
id: PTHR11909:SF367
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF366
type: RelationshipXref
id: PTHR11909:SF366
db: PANTHER Family
relationship type: By Homology

Complex (Bcl9/Beta-Catenin/ TCF/Smad4/ Pygo)
type: Complex
component stoichiometry: Smad4 s90 sa60 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pygo s91 sa61 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Catenin s88 sa58 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCF s89 sa59 STOICHIOMETRY ID COMPLEX
component stoichiometry: Bcl9 s87 sa57 STOICHIOMETRY ID COMPLEX
component: Smad4
component: Pygo s91 sa61
component: TCF s89 sa59
component: Bcl9
component: Beta Catenin s88 sa58
feature: COMPLEX BINDING FEATURE s183 a421 2315
feature: COMPLEX BINDING FEATURE s183 a421 2309
feature: COMPLEX BINDING FEATURE s183 a421 2311
feature: ACTIVE 50
feature: COMPLEX BINDING FEATURE s183 a421 2313
feature: COMPLEX BINDING FEATURE s183 a421 2307
cellular location: nucleus

uniprot P51531 363
type: UnificationXref
id: P51531
db: uniprot

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot F1PCS0 174
xref: PTHR24270:SF12
organism: Canis lupus familiaris

PTHR11909:SF374
type: RelationshipXref
id: PTHR11909:SF374
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q2TVV5 1011
type: UnificationXref
id: A0A3Q2TVV5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GTC1 56
xref: PTHR22611:SF2
organism: Macaca mulatta

uniprot Q3B7N0 851
type: UnificationXref
id: Q3B7N0
db: uniprot

uniprot E1B8D6 1401
type: UnificationXref
id: E1B8D6
db: uniprot

Tumor necrosis factor
type: DnaReference
xref: PTHR11471:SF23
organism: Rattus norvegicus

PTHR23056:SF26
type: RelationshipXref
id: PTHR23056:SF26
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF378
type: RelationshipXref
id: PTHR11909:SF378
db: PANTHER Family
relationship type: By Homology

Calcineurin B-like protein 2
type: ProteinReference
xref: PTHR23056:SF106
xref: uniprot Q3HRP5 1352
organism: Oryza sativa

uniprot Q803C3 2095
type: UnificationXref
id: Q803C3
db: uniprot

Protocadherin-11 X-linked
type: ProteinReference
xref: uniprot Q71M42 874
xref: PTHR24028:SF254
organism: Pan troglodytes

INO80 complex subunit
type: ProteinReference
xref: uniprot D4A6Q6 274
xref: PTHR45685:SF2
organism: Rattus norvegicus

Dishevelled
type: Protein
entity reference: Dishevelled
feature: COMPLEX PARTICIPANT BINDING FEATURE s150 sa135 2352
feature: Dishevelled s150 sa135 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1MKL7 461
type: UnificationXref
id: A0A3Q1MKL7
db: uniprot

Casein kinase I isoform gamma-3
type: ProteinReference
xref: PTHR11909:SF151
xref: uniprot Q8C4X2 1848
organism: Mus musculus

Bone morphogenetic protein receptor type-1B
type: ProteinReference
xref: uniprot O00238 1063
organism: Homo sapiens

PTHR10373:SF32
type: RelationshipXref
id: PTHR10373:SF32
db: PANTHER Family
relationship type: By Homology

PTHR10373:SF33
type: RelationshipXref
id: PTHR10373:SF33
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF383
type: RelationshipXref
id: PTHR11909:SF383
db: PANTHER Family
relationship type: By Homology

uniprot Q567Y8 583
type: UnificationXref
id: Q567Y8
db: uniprot

AGAP004298-PA
type: ProteinReference
xref: PTHR45942:SF1
xref: uniprot F5HLK4 1312
organism: Anopheles gambiae

PTHR19849:SF1
type: RelationshipXref
id: PTHR19849:SF1
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r92 2470
type: Stoichiometry
physical entity: betaTrCP
stoichiometric coefficient: 1.0

Axin-1
type: DnaReference
xref: PTHR46102:SF3
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR46342:SF1
xref: uniprot F7HGC0 2021
organism: Macaca mulatta

Casein kinase II, alpha chain, putative, expressed
type: ProteinReference
xref: PTHR24054:SF35
xref: uniprot Q10Q71 1763
organism: Oryza sativa

SWI/SNF and RSC complexes subunit ssr3
type: ProteinReference
xref: PTHR13844:SF7
xref: uniprot Q9P7S3 439
organism: 284812

Catenin (Cadherin associated protein), alpha-like 1 (Predicted)
type: ProteinReference
xref: uniprot D4A739 2011
xref: PTHR46342:SF1
organism: Rattus norvegicus

Adenomatous Polyposis Coli s62 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli
stoichiometric coefficient: 1.0

PTHR11909:SF353
type: RelationshipXref
id: PTHR11909:SF353
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24028:SF46
xref: uniprot F1MEC8 703
organism: Bos taurus

PTHR11909:SF356
type: RelationshipXref
id: PTHR11909:SF356
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF355
type: RelationshipXref
id: PTHR11909:SF355
db: PANTHER Family
relationship type: By Homology

uniprot F6USP1 726
type: UnificationXref
id: F6USP1
db: uniprot

Protocadherin 1
type: ProteinReference
xref: PTHR24028:SF247
xref: uniprot Q8CFX3 894
organism: Mus musculus

Frizzled-5
type: ProteinReference
xref: PTHR11309:SF136
xref: uniprot Q9EQD0 139
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r92 2468
type: Stoichiometry
physical entity: Complex (betaTrCP/Beta-Catenin)
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot Q4JLT0 1263
organism: Danio rerio

uniprot Q8CHL0 135
type: UnificationXref
id: Q8CHL0
db: uniprot

uniprot O46680 1065
type: UnificationXref
id: O46680
db: uniprot

PARTICIPANT STOICHIOMETRY r92 2469
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

uniprot F7EBN2 1992
type: UnificationXref
id: F7EBN2
db: uniprot

PARTICIPANT STOICHIOMETRY r72 2421
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

CSNK1G2 protein
type: ProteinReference
xref: PTHR11909:SF157
xref: uniprot A7MB90 1790
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r72 2422
type: Stoichiometry
physical entity: Complex (Galpha/Phospholipase C)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 2420
type: Stoichiometry
physical entity: Phospholipase C
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot H2QRN3 796
xref: PTHR24028:SF71
organism: Pan troglodytes

Protocadherin beta-5
type: ProteinReference
xref: PTHR24028:SF90
xref: uniprot H2QRN2 795
organism: Pan troglodytes

Casein kinase 1-like protein 10
type: ProteinReference
xref: uniprot Q9LW62 1868
xref: PTHR11909:SF383
organism: Arabidopsis thaliana

Histone deacetylase
type: ProteinReference
xref: uniprot H2QRN6 2063
xref: PTHR10625:SF201
organism: Pan troglodytes

Putative calcineurin B subunit
type: ProteinReference
xref: uniprot Q4QC21 1353
xref: PTHR45942:SF1
organism: Leishmania major

uniprot F7CXD0 1611
type: UnificationXref
id: F7CXD0
db: uniprot

Protocadherin 10
type: ProteinReference
xref: PTHR24028:SF0
xref: uniprot A0A3Q1LYG2 655
organism: Bos taurus

Diversin s114 sa86 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Diversin s114 sa86
stoichiometric coefficient: 1.0

uniprot F7GRQ8 769
type: UnificationXref
id: F7GRQ8
db: uniprot

uniprot F6Y3N2 1608
type: UnificationXref
id: F6Y3N2
db: uniprot

uniprot Q94517 2099
type: UnificationXref
id: Q94517
db: uniprot

Histone acetyltransferase HAC4
type: ProteinReference
xref: PTHR13808:SF30
xref: uniprot Q9LG11 1418
organism: Arabidopsis thaliana

PTHR19300:SF30
type: RelationshipXref
id: PTHR19300:SF30
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot A4IFL6 1918
organism: Bos taurus

uniprot Q02720 1762
type: UnificationXref
id: Q02720
db: uniprot

Glycogen Synthase Kinase 3Beta s50 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glycogen Synthase Kinase 3Beta s50 sa35
stoichiometric coefficient: 1.0

uniprot P62716 569
type: UnificationXref
id: P62716
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 33

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
type: ProteinReference
xref: uniprot Q80W83 594
xref: PTHR10257:SF4
organism: Rattus norvegicus

Uncharacterized protein
type: DnaReference
xref: PTHR10373:SF25
organism: Bos taurus

Transducin-like enhancer protein 2
type: ProteinReference
xref: PTHR10814:SF4
xref: uniprot Q04725 485
organism: Homo sapiens

Transducin-like enhancer protein 3
type: ProteinReference
xref: uniprot Q04726 486
xref: PTHR10814:SF24
organism: Homo sapiens

Transducin-like enhancer protein 1
type: ProteinReference
xref: uniprot Q04724 484
xref: PTHR10814:SF29
organism: Homo sapiens

Cadherin related 23
type: ProteinReference
xref: PTHR24027:SF425
xref: uniprot F1P8X5 712
organism: Canis lupus familiaris

uniprot P43446 1240
type: UnificationXref
id: P43446
db: uniprot

T-box transcription factor T
type: DnaReference
xref: PTHR11267:SF83
organism: Xenopus tropicalis

uniprot D4ACG6 275
type: UnificationXref
id: D4ACG6
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__Axin_PP2A__Adenomatous_Polyposis_Coli_-_Beta_Catenin-RIGHT__Complex__Adenomatous_Polyposis_Coli_Axin__Beta_Catenin_PP2A_-_r47
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 2398
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 2397
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 2399
left: Beta-Catenin
left: Complex Axin PP2A Adenomatous Polyposis Coli s121 a266
interaction type: HETERODIMER_ASSOCIATION
right: Complex Adenomatous Polyposis Coli Axin Beta Catenin PP2A s123 a275

uniprot A0A140T847 1126
type: UnificationXref
id: A0A140T847
db: uniprot

uniprot B0S5E7 72
type: UnificationXref
id: B0S5E7
db: uniprot

Protocadherin-11 Y-linked
type: ProteinReference
xref: PTHR24028:SF295
xref: uniprot Q9BZA8 935
organism: Homo sapiens

uniprot P48730 1826
type: UnificationXref
id: P48730
db: uniprot

Protocadherin-11 X-linked
type: ProteinReference
xref: uniprot Q9BZA7 934
xref: PTHR24028:SF254
organism: Homo sapiens

uniprot Q9Y5I1 1003
type: UnificationXref
id: Q9Y5I1
db: uniprot

Transducin-like enhancer protein 4
type: ProteinReference
xref: uniprot Q04727 487
xref: PTHR10814:SF31
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPU3 777
xref: PTHR24028:SF9
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR24028:SF97
xref: uniprot F6UY89 727
organism: Macaca mulatta

Protein Wnt-8a
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot Q64527 1265
organism: Mus musculus

Transcription factor 7-like 2
type: ProteinReference
xref: uniprot Q924A0 513
xref: PTHR10373:SF32
organism: Mus musculus

Beta-arrestin-1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot P17870 1577
organism: Bos taurus

Cadherin-1
type: ProteinReference
xref: uniprot P09803 812
xref: PTHR24027:SF319
organism: Mus musculus

Cadherin-related family member 1
type: ProteinReference
xref: PTHR24028:SF263
xref: uniprot Q96JP9 929
organism: Homo sapiens

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa45 2292
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protocadherin-18
type: ProteinReference
xref: uniprot A7MB46 661
xref: PTHR24028:SF9
organism: Bos taurus

ncbitaxon 54126 1808
type: UnificationXref
id: 54126
db: ncbitaxon

Transcription factor unc-37
type: ProteinReference
xref: PTHR10814:SF21
xref: uniprot O02482 478
organism: Caenorhabditis elegans

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot Q6P365 587
organism: Xenopus tropicalis

Protocadherin-16
type: ProteinReference
xref: PTHR24027:SF423
xref: uniprot Q96JQ0 930
organism: Homo sapiens

Protein CBR-ITR-1, isoform a
type: ProteinReference
xref: PTHR13715:SF87
xref: uniprot H8WGV2 29
organism: Caenorhabditis briggsae

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5P5C3 452
xref: PTHR10814:SF29
organism: 9031

Catenin (Cadherin-associated protein), alpha 1, 102kDa
type: ProteinReference
xref: PTHR18914:SF24
xref: uniprot H2QRK9 2024
organism: Pan troglodytes

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot A0A2I3TRC4 1440
organism: Pan troglodytes

uniprot P70701 1253
type: UnificationXref
id: P70701
db: uniprot

Adenomatous Polyposis Coli s177 sa95 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli s177 sa95
stoichiometric coefficient: 1.0

uniprot Q5BL72 124
type: UnificationXref
id: Q5BL72
db: uniprot

Serine35 Beta Catenin s76 sa40 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s76 sa40 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

Adenomatous Polyposis Coli s116 sa88 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli
stoichiometric coefficient: 1.0

uniprot P51030 1248
type: UnificationXref
id: P51030
db: uniprot

PTHR10878:SF8
type: RelationshipXref
id: PTHR10878:SF8
db: PANTHER Family
relationship type: By Homology

uniprot Q5NAX7 214
type: UnificationXref
id: Q5NAX7
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot H2QRH7 561
xref: PTHR45619:SF42
organism: Pan troglodytes

PTHR10878:SF5
type: RelationshipXref
id: PTHR10878:SF5
db: PANTHER Family
relationship type: By Homology

PTHR10878:SF6
type: RelationshipXref
id: PTHR10878:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q96JQ0 930
type: UnificationXref
id: Q96JQ0
db: uniprot

Cadherin-related family member 1
type: ProteinReference
xref: PTHR24028:SF263
xref: uniprot Q8VHP6 901
organism: Mus musculus

uniprot F7GRQ5 768
type: UnificationXref
id: F7GRQ5
db: uniprot

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot Q91398 1783
organism: Danio rerio

HETERODIMER_ASSOCIATION_LEFT__Casein_Kinase_2-_Complex__Dishevelled_Beta_Arrestin__Frodo_-RIGHT__Complex__Dishevelled_Beta_Arrestin__Frodo_Casein_Kinase_2_-_r102
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 2507
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 2508
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 2506
left: Complex (Dishevelled/Beta-Arrestin/ Frodo)
left: Casein Kinase 2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Dishevelled/Beta-Arrestin/ Frodo/Casein Kinase 2)

Secreted frizzled-related protein 1
type: ProteinReference
xref: PTHR11309:SF87
xref: uniprot F7EN59 231
organism: Xenopus tropicalis

PTHR10315:SF131
type: RelationshipXref
id: PTHR10315:SF131
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 2B catalytic subunit
type: ProteinReference
xref: PTHR45673:SF1
xref: uniprot Q0G819 1346
organism: Caenorhabditis elegans

Si:dkeyp-80c12.7
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot B8JIQ1 1012
organism: Danio rerio

uniprot P63078 1966
type: UnificationXref
id: P63078
db: uniprot

PARTICIPANT STOICHIOMETRY r96 2457
type: Stoichiometry
physical entity: Ubiquitin s268 a558
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r96 2458
type: Stoichiometry
physical entity: Complex Adenomatous Polyposis Coli Axin PP2A Beta Catenin Siah 1 Ebi s159 a368
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r96 2459
type: Stoichiometry
physical entity: Complex Adenomatous Polyposis Coli Beta Catenin Siah 1 Ebi Axin PP2A s275 a579
stoichiometric coefficient: 1.0

uniprot Q19266 1700
type: UnificationXref
id: Q19266
db: uniprot

uniprot P55284 828
type: UnificationXref
id: P55284
db: uniprot

PTHR10625:SF201
type: RelationshipXref
id: PTHR10625:SF201
db: PANTHER Family
relationship type: By Homology

uniprot Q9VVV9 62
type: UnificationXref
id: Q9VVV9
db: uniprot

PTHR10625:SF203
type: RelationshipXref
id: PTHR10625:SF203
db: PANTHER Family
relationship type: By Homology

uniprot Q3TKT4 384
type: UnificationXref
id: Q3TKT4
db: uniprot

uniprot F1MLJ8 82
type: UnificationXref
id: F1MLJ8
db: uniprot

PTHR10625:SF206
type: RelationshipXref
id: PTHR10625:SF206
db: PANTHER Family
relationship type: By Homology

PTHR10625:SF207
type: RelationshipXref
id: PTHR10625:SF207
db: PANTHER Family
relationship type: By Homology

PTHR10625:SF208
type: RelationshipXref
id: PTHR10625:SF208
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QG31 1439
type: UnificationXref
id: A0A1D5QG31
db: uniprot

uniprot A0A1D5NXB2 1374
type: UnificationXref
id: A0A1D5NXB2
db: uniprot

uniprot D3ZE55 662
type: UnificationXref
id: D3ZE55
db: uniprot

F-box and WD repeat domain-containing 11b
type: ProteinReference
xref: PTHR19854:SF16
xref: uniprot A0A2R8RWN9 1516
organism: Danio rerio

Phosrestin-2
type: ProteinReference
xref: uniprot P15372 1575
xref: PTHR11792:SF16
organism: Drosophila melanogaster

Casein Kinase 1 s126 sa94 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Casein Kinase 1
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: uniprot Q9YGX6 1287
xref: PTHR12027:SF33
organism: 9031

MODULATION
type: RelationshipTypeVocabulary

FZD1 protein
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot A7MB15 70
organism: Bos taurus

uniprot P18824 192
type: UnificationXref
id: P18824
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

Transducin like enhancer of split 2
type: ProteinReference
xref: PTHR10814:SF4
xref: uniprot H2R3W5 477
organism: Pan troglodytes

PTHR10336:SF106
type: RelationshipXref
id: PTHR10336:SF106
db: PANTHER Family
relationship type: By Homology

Frizzled-6
type: ProteinReference
xref: PTHR11309:SF75
xref: uniprot Q8WMU5 138
organism: Canis lupus familiaris

uniprot F1MW29 706
type: UnificationXref
id: F1MW29
db: uniprot

uniprot Q91UZ8 907
type: UnificationXref
id: Q91UZ8
db: uniprot

uniprot F7FAD4 317
type: UnificationXref
id: F7FAD4
db: uniprot

Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Axin/PP2A)
type: Complex
component stoichiometry: Beta Catenin s135 sa120 STOICHIOMETRY ID COMPLEX
component stoichiometry: PP2A s137 sa122 STOICHIOMETRY ID COMPLEX
component stoichiometry: Axin s136 sa121 STOICHIOMETRY ID COMPLEX
component stoichiometry: Adenomatous Polyposis Coli s134 sa119 STOICHIOMETRY ID COMPLEX
component: Adenomatous Polyposis Coli s134 sa119
component: PP2A
component: Beta-Catenin
component: Axin s136 sa121
feature: COMPLEX BINDING FEATURE s278 a582 2367
feature: COMPLEX BINDING FEATURE s278 a582 2365
feature: COMPLEX BINDING FEATURE s278 a582 2363
feature: COMPLEX BINDING FEATURE s278 a582 2361
cellular location: plasma membrane

PTHR10315:SF117
type: RelationshipXref
id: PTHR10315:SF117
db: PANTHER Family
relationship type: By Homology

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 1715

uniprot E2R4F0 680
type: UnificationXref
id: E2R4F0
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF2
xref: uniprot F6X434 1315
organism: 9258

PP2A s51 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10799:SF819
xref: uniprot F7FAD4 317
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HA59 773
xref: PTHR24028:SF46
organism: Macaca mulatta

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF70
xref: uniprot A0A140T847 1126
organism: Bos taurus

uniprot R4GKD1 1990
type: UnificationXref
id: R4GKD1
db: uniprot

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot P19139 1746
xref: PTHR24054:SF16
organism: Rattus norvegicus

Uncharacterized protein
type: DnaReference
xref: PTHR45615:SF2
organism: 9031

PTHR10315:SF106
type: RelationshipXref
id: PTHR10315:SF106
db: PANTHER Family
relationship type: By Homology

uniprot P57095 166
type: UnificationXref
id: P57095
db: uniprot

Putative casein kinase II
type: ProteinReference
xref: PTHR24054:SF46
xref: uniprot E9AEZ4 1722
organism: Leishmania major

Helicase-like transcription factor
type: ProteinReference
xref: uniprot H2R3U6 332
xref: PTHR45626:SF39
organism: Pan troglodytes

FAT atypical cadherin 2
type: ProteinReference
xref: uniprot H2QRU2 798
xref: PTHR24026:SF37
organism: Pan troglodytes

uniprot F7CCH6 472
type: UnificationXref
id: F7CCH6
db: uniprot

Frizzled-7
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot A0A1D5PEJ9 64
organism: 9031

uniprot F6QLT3 2005
type: UnificationXref
id: F6QLT3
db: uniprot

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P20651 1325
xref: PTHR45673:SF7
organism: Rattus norvegicus

Protocadherin gamma-A5
type: ProteinReference
xref: PTHR24028:SF105
xref: uniprot Q9Y5G8 991
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF73
xref: uniprot X1WEJ5 1288
organism: Danio rerio

Protocadherin gamma-A6
type: ProteinReference
xref: uniprot Q9Y5G7 990
xref: PTHR24028:SF107
organism: Homo sapiens

Protocadherin gamma-A7
type: ProteinReference
xref: uniprot Q9Y5G6 989
xref: PTHR24028:SF56
organism: Homo sapiens

Protocadherin gamma-A8
type: ProteinReference
xref: uniprot Q9Y5G5 988
xref: PTHR24028:SF72
organism: Homo sapiens

Beta Catenin s232 a380 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Protocadherin gamma-B1
type: ProteinReference
xref: uniprot Q9Y5G3 987
xref: PTHR24028:SF106
organism: Homo sapiens

Glycogen synthase kinase 3
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot Q9YH60 1028
organism: Danio rerio

Protocadherin gamma-B2
type: ProteinReference
xref: uniprot Q9Y5G2 986
xref: PTHR24028:SF144
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: uniprot F1N6L8 1171
xref: PTHR12027:SF78
organism: Bos taurus

uniprot P21552 1225
type: UnificationXref
id: P21552
db: uniprot

Nemo-like Kinase
type: Protein
entity reference: Nemo-like Kinase
feature: Nemo like Kinase s235 a497 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot A3KGF7 1093
type: UnificationXref
id: A3KGF7
db: uniprot

Cadherin-99C
type: ProteinReference
xref: PTHR24026:SF93
xref: uniprot Q9VAF5 964
organism: Drosophila melanogaster

Secreted frizzled-related protein 4
type: ProteinReference
xref: uniprot Q9JLS4 1892
xref: PTHR11309:SF7
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPS9 1911
xref: PTHR23194:SF7
organism: Macaca mulatta

Protocadherin beta-13
type: ProteinReference
xref: uniprot Q9Y5F0 978
xref: PTHR24028:SF61
organism: Homo sapiens

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot Q8AXX6 595
organism: Danio rerio

uniprot Q9Y5E3 971
type: UnificationXref
id: Q9Y5E3
db: uniprot

Protocadherin gamma-C5
type: ProteinReference
xref: PTHR24028:SF258
xref: uniprot Q9Y5F6 982
organism: Homo sapiens

Protocadherin gamma-B7
type: ProteinReference
xref: PTHR24028:SF113
xref: uniprot Q9Y5F8 984
organism: Homo sapiens

Protocadherin gamma-C4
type: ProteinReference
xref: PTHR24028:SF272
xref: uniprot Q9Y5F7 983
organism: Homo sapiens

Protocadherin beta-11
type: ProteinReference
xref: PTHR24028:SF286
xref: uniprot Q9Y5F2 980
organism: Homo sapiens

Protocadherin beta-12
type: ProteinReference
xref: PTHR24028:SF91
xref: uniprot Q9Y5F1 979
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPS8 776
xref: PTHR24027:SF96
organism: Macaca mulatta

Protocadherin beta-1
type: ProteinReference
xref: PTHR24028:SF12
xref: uniprot Q9Y5F3 981
organism: Homo sapiens

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Emericella nidulans

Protocadherin gamma-B6
type: ProteinReference
xref: PTHR24028:SF66
xref: uniprot Q9Y5F9 985
organism: Homo sapiens

ncbitaxon 190304 418
type: UnificationXref
id: 190304
db: ncbitaxon

Protocadherin alpha-1
type: ProteinReference
xref: uniprot Q9Y5I3 1005
xref: PTHR24028:SF92
organism: Homo sapiens

CREB binding protein
type: ProteinReference
xref: uniprot F1PY87 1403
xref: PTHR13808:SF34
organism: Canis lupus familiaris

Protocadherin alpha-10
type: ProteinReference
xref: PTHR24028:SF124
xref: uniprot Q9Y5I2 1004
organism: Homo sapiens

Protocadherin alpha-11
type: ProteinReference
xref: uniprot Q9Y5I1 1003
xref: PTHR24028:SF68
organism: Homo sapiens

Protocadherin alpha-13
type: ProteinReference
xref: PTHR24028:SF101
xref: uniprot Q9Y5I0 1002
organism: Homo sapiens

uniprot Q5DRC7 856
type: UnificationXref
id: Q5DRC7
db: uniprot

Protocadherin alpha-C2
type: ProteinReference
xref: PTHR24028:SF119
xref: uniprot Q9Y5I4 1006
organism: Homo sapiens

uniprot Q9NFZ3 1986
type: UnificationXref
id: Q9NFZ3
db: uniprot

Adenomatous Polyposis Coli s43 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli
stoichiometric coefficient: 1.0

uniprot P48457 1335
type: UnificationXref
id: P48457
db: uniprot

PTHR10019:SF5
type: RelationshipXref
id: PTHR10019:SF5
db: PANTHER Family
relationship type: By Homology

INO80 complex subunit
type: ProteinReference
xref: PTHR45685:SF2
xref: uniprot H2R3P6 331
organism: Pan troglodytes

uniprot Q0V1Y4 1347
type: UnificationXref
id: Q0V1Y4
db: uniprot

PCDH12 isoform 1
type: ProteinReference
xref: PTHR24028:SF42
xref: uniprot H2QRP0 797
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot P13217 1111
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR10814:SF29
xref: uniprot F7G015 473
organism: Monodelphis domestica

uniprot Q9Y5H8 1000
type: UnificationXref
id: Q9Y5H8
db: uniprot

Adenomatous Polyposis Coli s127 sa113 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli
stoichiometric coefficient: 1.0

uniprot Q61271 1081
type: UnificationXref
id: Q61271
db: uniprot

uniprot Q78EA7 1084
type: UnificationXref
id: Q78EA7
db: uniprot

Protocadherin gamma-A3
type: ProteinReference
xref: uniprot Q9Y5H0 992
xref: PTHR24028:SF234
organism: Homo sapiens

Protocadherin gamma-A11
type: ProteinReference
xref: uniprot Q9Y5H2 994
xref: PTHR24028:SF84
organism: Homo sapiens

Protocadherin gamma-A2
type: ProteinReference
xref: PTHR24028:SF134
xref: uniprot Q9Y5H1 993
organism: Homo sapiens

Protocadherin gamma-A1
type: ProteinReference
xref: uniprot Q9Y5H4 996
xref: PTHR24028:SF108
organism: Homo sapiens

Protocadherin gamma-A10
type: ProteinReference
xref: uniprot Q9Y5H3 995
xref: PTHR24028:SF110
organism: Homo sapiens

Protocadherin alpha-8
type: ProteinReference
xref: PTHR24028:SF133
xref: uniprot Q9Y5H6 998
organism: Homo sapiens

Protocadherin alpha-9
type: ProteinReference
xref: uniprot Q9Y5H5 997
xref: PTHR24028:SF255
organism: Homo sapiens

Protocadherin alpha-3
type: ProteinReference
xref: PTHR24028:SF93
xref: uniprot Q9Y5H8 1000
organism: Homo sapiens

uniprot H2QRN3 796
type: UnificationXref
id: H2QRN3
db: uniprot

Protocadherin alpha-5
type: ProteinReference
xref: PTHR24028:SF111
xref: uniprot Q9Y5H7 999
organism: Homo sapiens

Protocadherin alpha-2
type: ProteinReference
xref: PTHR24028:SF60
xref: uniprot Q9Y5H9 1001
organism: Homo sapiens

Bcl9
type: Protein
entity reference: Bcl9 PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s87 sa57 2308
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Threonine41 Beta Catenin s82 sa52 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s82 sa52 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

Chromatin structure-remodeling complex protein SYD
type: ProteinReference
xref: PTHR10799:SF973
xref: uniprot F4IHS2 294
organism: Arabidopsis thaliana

PTHR24026:SF51
type: RelationshipXref
id: PTHR24026:SF51
db: PANTHER Family
relationship type: By Homology

Casein Kinase 1
type: Protein
entity reference: Casein Kinase 1
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa34 2180
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Kremen protein 1
type: ProteinReference
xref: uniprot Q924S4 1903
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: uniprot E2RTG8 1165
xref: PTHR12027:SF91
organism: Canis lupus familiaris

Casein kinase I homolog HRR25
type: ProteinReference
xref: uniprot P29295 1816
xref: PTHR11909:SF18
organism: Saccharomyces cerevisiae

Serine35 Beta Catenin s111 sa83 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s111 sa83 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

PTHR24028:SF272
type: RelationshipXref
id: PTHR24028:SF272
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR23257:SF700
xref: uniprot Q9V3Q6 1087
organism: Drosophila melanogaster

uniprot F7CBX9 752
type: UnificationXref
id: F7CBX9
db: uniprot

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Anopheles gambiae

TRANSPORT
type: RelationshipTypeVocabulary

PTHR24026:SF49
type: RelationshipXref
id: PTHR24026:SF49
db: PANTHER Family
relationship type: By Homology

Pygopus family PHD finger 1
type: ProteinReference
xref: uniprot F1M5T3 1907
xref: PTHR23194:SF3
organism: Rattus norvegicus

Myosin, heavy polypeptide 1.2, skeletal muscle
type: DnaReference
xref: PTHR45615:SF44
organism: Danio rerio

Myosin, heavy polypeptide 1.3, skeletal muscle
type: DnaReference
xref: PTHR45615:SF44
organism: Danio rerio

PTHR24026:SF42
type: RelationshipXref
id: PTHR24026:SF42
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r102 2506
type: Stoichiometry
physical entity: Casein Kinase 2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r102 2507
type: Stoichiometry
physical entity: Complex (Dishevelled/Beta-Arrestin/ Frodo)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r102 2508
type: Stoichiometry
physical entity: Complex (Dishevelled/Beta-Arrestin/ Frodo/Casein Kinase 2)
stoichiometric coefficient: 1.0

Homeobox protein engrailed-like
type: DnaReference
xref: PTHR24341:SF5
organism: Rattus norvegicus

uniprot A0A2R8QIW0 2046
type: UnificationXref
id: A0A2R8QIW0
db: uniprot

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot F1PXA0 175
xref: PTHR46513:SF16
organism: Canis lupus familiaris

PTHR24028:SF260
type: RelationshipXref
id: PTHR24028:SF260
db: PANTHER Family
relationship type: By Homology

PTHR24028:SF263
type: RelationshipXref
id: PTHR24028:SF263
db: PANTHER Family
relationship type: By Homology

PTHR24028:SF265
type: RelationshipXref
id: PTHR24028:SF265
db: PANTHER Family
relationship type: By Homology

uniprot Q91UZ1 1118
type: UnificationXref
id: Q91UZ1
db: uniprot

uniprot Q9WVB3 498
type: UnificationXref
id: Q9WVB3
db: uniprot

uniprot A0A2I3TRC4 1440
type: UnificationXref
id: A0A2I3TRC4
db: uniprot

uniprot Q08463 119
type: UnificationXref
id: Q08463
db: uniprot

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot Q967X2 1784
xref: PTHR11740:SF0
organism: 7719

uniprot F1LNL2 287
type: UnificationXref
id: F1LNL2
db: uniprot

PTHR24028:SF295
type: RelationshipXref
id: PTHR24028:SF295
db: PANTHER Family
relationship type: By Homology

uniprot Q3B7N1 383
type: UnificationXref
id: Q3B7N1
db: uniprot

Protein Wnt-6
type: ProteinReference
xref: uniprot Q9Y6F9 1286
xref: PTHR12027:SF72
organism: Homo sapiens

Pygo
type: ProteinReference
xref: P01464
standard name: Pygopus
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Pygo
comment: ENTITY_REFERENCE_NOTES= Long Name: Pygopus Synonym: Pygopus Accession: P01464
member entity reference: Q9V9W8
member entity reference: Pygopus homolog 1
member entity reference: Pygopus 2
member entity reference: F6TM66
member entity reference: Pygopus homolog 2
member entity reference: PYGO2 isoform 3
member entity reference: Uncharacterized protein
member entity reference: Pygopus family PHD finger 1

uniprot D3ZRW5 1154
type: UnificationXref
id: D3ZRW5
db: uniprot

uniprot G3V987 783
type: UnificationXref
id: G3V987
db: uniprot

PTHR24028:SF298
type: RelationshipXref
id: PTHR24028:SF298
db: PANTHER Family
relationship type: By Homology

Siah-1
type: Protein
entity reference: Siah 1 PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 sa41 2232
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Actin, aortic smooth muscle
type: DnaReference
xref: PTHR11937:SF445
organism: Bos taurus

NKD2, WNT-signaling pathway inhibitor
type: ProteinReference
xref: PTHR22611:SF1
xref: uniprot D4A182 54
organism: Rattus norvegicus

uniprot A0A1D5RD87 1708
type: UnificationXref
id: A0A1D5RD87
db: uniprot

uniprot F1PQM2 1566
type: UnificationXref
id: F1PQM2
db: uniprot

E3 ubiquitin-protein ligase SIAH1B
type: ProteinReference
xref: uniprot Q06985 211
xref: PTHR45877:SF1
organism: Mus musculus

E3 ubiquitin-protein ligase SIAH2
type: ProteinReference
xref: uniprot Q06986 212
organism: Mus musculus

Protein Wnt
type: ProteinReference
xref: uniprot F6PMQ6 1173
xref: PTHR12027:SF33
organism: Monodelphis domestica

PTHR24028:SF284
type: RelationshipXref
id: PTHR24028:SF284
db: PANTHER Family
relationship type: By Homology

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 20

PTHR24028:SF286
type: RelationshipXref
id: PTHR24028:SF286
db: PANTHER Family
relationship type: By Homology

PTHR24028:SF281
type: RelationshipXref
id: PTHR24028:SF281
db: PANTHER Family
relationship type: By Homology

PTHR24026:SF38
type: RelationshipXref
id: PTHR24026:SF38
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TU99 645
type: UnificationXref
id: A0A2I3TU99
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F1NG47 1658
xref: PTHR24356:SF159
organism: 9031

Frizzled-2
type: ProteinReference
xref: uniprot Q14332 122
xref: PTHR11309:SF34
organism: Homo sapiens

uniprot Q9IA96 244
type: UnificationXref
id: Q9IA96
db: uniprot

PTHR24026:SF32
type: RelationshipXref
id: PTHR24026:SF32
db: PANTHER Family
relationship type: By Homology

PTHR24026:SF37
type: RelationshipXref
id: PTHR24026:SF37
db: PANTHER Family
relationship type: By Homology

PTHR24026:SF36
type: RelationshipXref
id: PTHR24026:SF36
db: PANTHER Family
relationship type: By Homology

Myosin-8
type: DnaReference
xref: PTHR45615:SF35
organism: Canis lupus familiaris

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot A0A0D1E0Y7 2043
organism: Ustilago maydis

Uncharacterized protein
type: DnaReference
xref: PTHR45851:SF2
organism: Pan troglodytes

PP2A
type: Protein
entity reference: PP2A
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Phosrestin-1
type: ProteinReference
xref: PTHR11792:SF23
xref: uniprot P19107 1578
organism: Drosophila melanogaster

F-box-like/WD repeat-containing protein TBL1XR1
type: ProteinReference
xref: PTHR22846:SF40
xref: uniprot Q9BZK7 1508
organism: Homo sapiens

uniprot F6X434 1315
type: UnificationXref
id: F6X434
db: uniprot

uniprot Q38C74 2085
type: UnificationXref
id: Q38C74
db: uniprot

Axin
type: Protein
entity reference: Axin
feature: COMPLEX PARTICIPANT BINDING FEATURE s189 sa104 2126
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7D1A1 1185
type: UnificationXref
id: F7D1A1
db: uniprot

uniprot Q7Q371 1504
type: UnificationXref
id: Q7Q371
db: uniprot

Protein Wnt-9a
type: ProteinReference
xref: uniprot O14904 1214
xref: PTHR12027:SF75
organism: Homo sapiens

Protein Wnt-9b
type: ProteinReference
xref: uniprot O14905 1215
xref: PTHR12027:SF84
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 1643
xref: PTHR19850:SF28
organism: Homo sapiens

ncbitaxon 10228 533
type: UnificationXref
id: 10228
db: ncbitaxon

uniprot F1MMW5 705
type: UnificationXref
id: F1MMW5
db: uniprot

uniprot Q6PB90 872
type: UnificationXref
id: Q6PB90
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot G3X6Y5 784
xref: PTHR24028:SF260
organism: Bos taurus

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa39 2228
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

FZD3 isoform 1
type: ProteinReference
xref: uniprot A0A2J8N8E6 67
xref: PTHR11309:SF22
organism: Pan troglodytes

ncbitaxon 284812 341
type: UnificationXref
id: 284812
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A2I3T8F7 1090
xref: PTHR10336:SF11
organism: Pan troglodytes

uniprot F6PGC8 1606
type: UnificationXref
id: F6PGC8
db: uniprot

uniprot F7DI28 1187
type: UnificationXref
id: F7DI28
db: uniprot

uniprot H9EU39 1670
type: UnificationXref
id: H9EU39
db: uniprot

uniprot F7BIQ7 748
type: UnificationXref
id: F7BIQ7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot Q99JE6 1119
organism: Rattus norvegicus

Histone deacetylase
type: ProteinReference
xref: uniprot F6YIM6 2056
xref: PTHR10625:SF203
organism: Monodelphis domestica

uniprot F6SJ04 722
type: UnificationXref
id: F6SJ04
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 336

Actin, alpha skeletal muscle
type: DnaReference
xref: PTHR11937:SF193
organism: Bos taurus

uniprot P40234 1821
type: UnificationXref
id: P40234
db: uniprot

uniprot Q803H5 1642
type: UnificationXref
id: Q803H5
db: uniprot

PP2A s40 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A s40 sa18
stoichiometric coefficient: 1.0

uniprot Q7K6A1 2091
type: UnificationXref
id: Q7K6A1
db: uniprot

Smad4 s58 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smad4 s58 sa47
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 2413
type: Stoichiometry
physical entity: Protein Kinase C
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 2414
type: Stoichiometry
physical entity: Protein Kinase C
stoichiometric coefficient: 1.0

Alpha-catulin
type: ProteinReference
xref: PTHR46342:SF1
xref: uniprot Q9UBT7 2039
organism: Homo sapiens

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
type: ProteinReference
xref: uniprot A0A452DHZ0 264
xref: PTHR45766:SF3
organism: Bos taurus

uniprot D4A6Q6 274
type: UnificationXref
id: D4A6Q6
db: uniprot

Protocadherin-16
type: ProteinReference
xref: uniprot E9PVD3 688
xref: PTHR24027:SF423
organism: Mus musculus

uniprot P56545 610
type: UnificationXref
id: P56545
db: uniprot

uniprot Q9Y2G4 1995
type: UnificationXref
id: Q9Y2G4
db: uniprot

DISSOCIATION_LEFT__Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Siah_1_Ebi__Axin_PP2A_-RIGHT__Complex__Siah_1_Ebi_-_Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Axin_PP2A_-_r98
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 2442
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 2441
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 2440
left: Complex Adenomatous Polyposis Coli Beta Catenin Siah 1 Ebi Axin PP2A s275 a579
interaction type: DISSOCIATION
right: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Axin/PP2A)
right: Complex (Siah-1/Ebi)

Protein Wnt
type: ProteinReference
xref: uniprot F6ZQ88 1184
xref: PTHR12027:SF101
organism: Xenopus tropicalis

Casein kinase I isoform delta-B
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q6P3K7 1842
organism: Danio rerio

uniprot Q7JWT4 1844
type: UnificationXref
id: Q7JWT4
db: uniprot

PTHR19855:SF12
type: RelationshipXref
id: PTHR19855:SF12
db: PANTHER Family
relationship type: By Homology

uniprot Q8QGH3 896
type: UnificationXref
id: Q8QGH3
db: uniprot

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot A0A0G2K0H3 168
xref: PTHR24270:SF12
organism: Rattus norvegicus

ncbitaxon 44689 387
type: UnificationXref
id: 44689
db: ncbitaxon

HETERODIMER_ASSOCIATION_LEFT__Ebi-_Siah_1-RIGHT__Complex__Ebi_Siah_1_-_r21
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 2535
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 2534
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 2533
left: Ebi
left: Siah-1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Ebi/Siah-1)

uniprot Q3ULA2 1526
type: UnificationXref
id: Q3ULA2
db: uniprot

Protocadherin Fat 3
type: ProteinReference
xref: uniprot Q8TDW7 900
xref: PTHR24026:SF49
organism: Homo sapiens

Probable helicase
type: ProteinReference
xref: uniprot Q9I5D9 434
xref: PTHR10799:SF923
organism: Pseudomonas aeruginosa

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q15147 1116
organism: Homo sapiens

FAT atypical cadherin 3
type: ProteinReference
xref: uniprot A0A2I3RVF5 638
xref: PTHR24026:SF49
organism: Pan troglodytes

Myosin-4
type: DnaReference
xref: PTHR45615:SF2
organism: Canis lupus familiaris

Homeobox protein engrailed-1
type: DnaReference
xref: PTHR24341:SF4
organism: Mus musculus

uniprot D4A9J2 1158
type: UnificationXref
id: D4A9J2
db: uniprot

uniprot A4IGZ2 1919
type: UnificationXref
id: A4IGZ2
db: uniprot

PANTHER Pathway P00057 1
type: UnificationXref
id: P00057
db: PANTHER Pathway

Histone deacetylase 8
type: ProteinReference
xref: uniprot Q8VH37 2097
xref: PTHR10625:SF109
organism: Mus musculus

uniprot Q3KRE3 1976
type: UnificationXref
id: Q3KRE3
db: uniprot

betaTrCP s185 sa101 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: betaTrCP s185 sa101
stoichiometric coefficient: 1.0

uniprot O13788 342
type: UnificationXref
id: O13788
db: uniprot

Protein Wnt-16
type: ProteinReference
xref: PTHR12027:SF70
xref: uniprot Q9UBV4 1283
organism: Homo sapiens

uniprot A5D7T5 1300
type: UnificationXref
id: A5D7T5
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 37

Nuclear factor of activated T cells 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot H2R4F5 1480
organism: Pan troglodytes

Transducin-like Enhance of Split 1-3
type: ProteinReference
xref: P01436
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Transducin-like Enhance of Split 1-3 Synonym: Groucho,TLE-1,TLE-2,TLE-3,Transducin-like Enhancer of Split 1,Transducin-like Enhancer of Split 2,Transducin-like Enhancer of Split 3 Accession: P01436
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Transducin-like Enhance of Split 1-3
member entity reference: Uncharacterized protein
member entity reference: Transducin like enhancer of split 4
member entity reference: TLE4 isoform 7
member entity reference: TLE3 isoform 10
member entity reference: Transducin-like enhancer protein 1
member entity reference: Q08117
member entity reference: Q7PMQ2
member entity reference: Q28C95
member entity reference: F7CCH6
member entity reference: Transducin-like enhancer protein 4
member entity reference: Transducin-like enhancer of split 4
member entity reference: TLE family member 1, transcriptional corepressor
member entity reference: Transducin-like enhancer of split 1
member entity reference: F1PKX6
member entity reference: Transcription factor unc-37
member entity reference: Transducin like enhancer of split 1
member entity reference: TLE family member 5
member entity reference: TLE family member 2, transcriptional corepressor
member entity reference: Transducin-like enhancer of split 2
member entity reference: Protein groucho
member entity reference: O13166
member entity reference: A0A3Q1LJY1
member entity reference: Transducin-like enhancer protein 2
member entity reference: Transducin like enhancer of split 2
member entity reference: O13168
member entity reference: H2QEX8
member entity reference: Transducin-like enhancer protein 6
member entity reference: Chico
member entity reference: Transducin like enhancer of split 3
member entity reference: Q08122
member entity reference: F7C424
member entity reference: Transducin-like enhancer protein 3

uniprot A0A2I3TJ60 1472
type: UnificationXref
id: A0A2I3TJ60
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UHL5 1567
xref: PTHR11792:SF20
organism: Macaca mulatta

uniprot Q8VYK9 1855
type: UnificationXref
id: Q8VYK9
db: uniprot

uniprot P56520 2077
type: UnificationXref
id: P56520
db: uniprot

uniprot P70340 1546
type: UnificationXref
id: P70340
db: uniprot

ncbitaxon 188937 423
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot F7DX53 314
type: UnificationXref
id: F7DX53
db: uniprot

Transcription factor 7-like 1-A
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot Q9YHE8 519
organism: Danio rerio

uniprot F6S1W0 721
type: UnificationXref
id: F6S1W0
db: uniprot

uniprot P0C8E4 1066
type: UnificationXref
id: P0C8E4
db: uniprot

Axin 1
type: DnaReference
xref: PTHR46102:SF3
organism: Xenopus tropicalis

Complex (Dishevelled/Beta-Arrestin/ Frodo)
type: Complex
component stoichiometry: Dishevelled s143 sa128 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Arrestin s144 sa129 STOICHIOMETRY ID COMPLEX
component stoichiometry: Frodo s145 sa130 STOICHIOMETRY ID COMPLEX
component: Beta-Arrestin
component: Frodo
component: Dishevelled
feature: COMPLEX BINDING FEATURE s286 a609 2337
feature: ACTIVE 50
feature: COMPLEX BINDING FEATURE s286 a609 2333
feature: COMPLEX BINDING FEATURE s286 a609 2335
cellular location: plasma membrane

uniprot E9PTG1 286
type: UnificationXref
id: E9PTG1
db: uniprot

uniprot Q91VN0 184
type: UnificationXref
id: Q91VN0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Dishevelled_Beta_Arrestin__Frodo_-_ATP-RIGHT__ADP-_Complex__Dishevelled_Beta_Arrestin__Frodo_-_r104
controller: Casein Kinase 1

uniprot Q5EAP4 1464
type: UnificationXref
id: Q5EAP4
db: uniprot

uniprot F1PDW7 466
type: UnificationXref
id: F1PDW7
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
type: ProteinReference
xref: uniprot Q15173 581
xref: PTHR10257:SF4
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
type: ProteinReference
xref: uniprot Q15172 580
xref: PTHR10257:SF6
organism: Homo sapiens

Beta Catenin s184 sa100 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Homeobox protein engrailed-2
type: DnaReference
xref: PTHR24341:SF5
organism: Mus musculus

uniprot Q28IC7 1257
type: UnificationXref
id: Q28IC7
db: uniprot

uniprot P62714 567
type: UnificationXref
id: P62714
db: uniprot

uniprot K7BXC2 1993
type: UnificationXref
id: K7BXC2
db: uniprot

Protocadherin Fat 3
type: ProteinReference
xref: uniprot Q8BNA6 892
xref: PTHR24026:SF49
organism: Mus musculus

LRP5/6
type: ProteinReference
xref: P01431
standard name: Low density lipoprotein receptor related protein
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.RECEPTOR.LRP5/6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
comment: ENTITY_REFERENCE_NOTES= Long Name: Low density lipoprotein receptor related protein Synonym: Arrow Accession: P01431
member entity reference: O88572
member entity reference: Low-density lipoprotein receptor-related protein
member entity reference: F1N1K8
member entity reference: H2Q5G9
member entity reference: Q91VN0
member entity reference: LDL receptor related protein 6
member entity reference: AGAP011770-PA (Fragment)
member entity reference: Low-density lipoprotein receptor-related protein 6
member entity reference: Low-density lipoprotein receptor-related protein 5

IP3 Gated Calcium Channel
type: ProteinReference
xref: P01426
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES= Long Name: IP3 Gated Calcium Channel Synonym: IP-3-R,IP3-Gated Ca Channel,Ins3PR Accession: P01426
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.ION_CHANNEL.IP_sub_3_endsub_ Gated Calcium Channel
member entity reference: F6ZCW7
member entity reference: Inositol 1,4,5-trisphosphate receptor
member entity reference: Inositol 1,4,5-trisphosphate receptor type 3
member entity reference: H2QSU0
member entity reference: H9FU38
member entity reference: Inositol 1,4,5-trisphosphate receptor type 2
member entity reference: Q14571
member entity reference: Q14643
member entity reference: F7A818
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: Uncharacterized protein
member entity reference: E2RMC0
member entity reference: Q14573
member entity reference: AGAP006475-PA
member entity reference: Protein CBR-ITR-1, isoform a
member entity reference: F6VQP7
member entity reference: Inositol 1,4,5-trisphosphate receptor itr-1

STATE TRANSITION LEFT Complex Adenomatous Polyposis Coli Axin Diversin Beta Catenin PP2A - ATP-RIGHT ADP- Complex Adenomatous Polyposis Coli Beta Catenin Axin PP2A Diversin Casein Kinase 1 - r85
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 2530
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 2529
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 2532
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 2531
left: ATP
left: Complex (Adenomatous Polyposis Coli/Axin/ Diversin/Beta-Catenin/ PP2A)
display name: STATE_TRANSITION_LEFT__Complex__Adenomatous_Polyposis_Coli_Axin__Diversin_Beta_Catenin__PP2A_-_ATP-RIGHT__ADP-_Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Axin_PP2A__Diversin_Casein_Kinase_1_-_r85
interaction type: STATE_TRANSITION
right: ADP
right: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Axin/PP2A/ Diversin/Casein Kinase 1)

uniprot A0A1D5REM7 499
type: UnificationXref
id: A0A1D5REM7
db: uniprot

uniprot G5EGU1 1449
type: UnificationXref
id: G5EGU1
db: uniprot

uniprot F7A4E9 310
type: UnificationXref
id: F7A4E9
db: uniprot

uniprot Q9UJU2 517
type: UnificationXref
id: Q9UJU2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NFY6 2051
xref: PTHR10625:SF109
organism: 9031

uniprot Q96L91 429
type: UnificationXref
id: Q96L91
db: uniprot

uniprot H2QQP8 794
type: UnificationXref
id: H2QQP8
db: uniprot

betaTrCP
type: Protein
entity reference: beta TrCP PROTEIN
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0G2K3B7 1124
type: UnificationXref
id: A0A0G2K3B7
db: uniprot

ncbitaxon 83332 336
type: UnificationXref
id: 83332
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot E2RT75 1094
xref: PTHR10336:SF10
organism: Canis lupus familiaris

uniprot F7ET26 761
type: UnificationXref
id: F7ET26
db: uniprot

uniprot E2R790 681
type: UnificationXref
id: E2R790
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P16520 1618
organism: Homo sapiens

uniprot Q8VHR0 902
type: UnificationXref
id: Q8VHR0
db: uniprot

uniprot E1C3Q9 201
type: UnificationXref
id: E1C3Q9
db: uniprot

uniprot Q12841 1255
type: UnificationXref
id: Q12841
db: uniprot

Activin receptor type-1B
type: ProteinReference
xref: uniprot Q61271 1081
organism: Mus musculus

uniprot O43255 208
type: UnificationXref
id: O43255
db: uniprot

IP3
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cadherin-related hmr-1
type: ProteinReference
xref: PTHR24026:SF102
xref: uniprot Q967F4 928
organism: Caenorhabditis elegans

uniprot F1M7Y5 1655
type: UnificationXref
id: F1M7Y5
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot W4ZAK5 597
xref: PTHR45619:SF12
organism: 7668

uniprot Q80SZ7 1981
type: UnificationXref
id: Q80SZ7
db: uniprot

uniprot Q9Y5F1 979
type: UnificationXref
id: Q9Y5F1
db: uniprot

Naked cuticle homolog 2
type: ProteinReference
xref: uniprot A0A2I3RW11 52
xref: PTHR22611:SF1
organism: Pan troglodytes

E1A-binding protein p400
type: ProteinReference
xref: uniprot Q96L91 429
xref: PTHR46459:SF1
organism: Homo sapiens

uniprot A0A2I3SMC0 1514
type: UnificationXref
id: A0A2I3SMC0
db: uniprot

uniprot A0A1D5RD22 1561
type: UnificationXref
id: A0A1D5RD22
db: uniprot

Kremen
type: Protein
entity reference: Kremen
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa4 2218
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q8WQ99 1858
type: UnificationXref
id: Q8WQ99
db: uniprot

uniprot O60907 1503
type: UnificationXref
id: O60907
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F6TQN3 1099
organism: Monodelphis domestica

uniprot H2QNU7 1387
type: UnificationXref
id: H2QNU7
db: uniprot

Secreted frizzled-related protein 1
type: ProteinReference
xref: PTHR11309:SF87
xref: uniprot O19116 236
organism: Bos taurus

Histone deacetylase
type: ProteinReference
xref: uniprot Q7KTS4 2092
xref: PTHR10625:SF201
organism: Drosophila melanogaster

uniprot Q9Y5E4 972
type: UnificationXref
id: Q9Y5E4
db: uniprot

uniprot H2R3W5 477
type: UnificationXref
id: H2R3W5
db: uniprot

Dickkopf
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Y5G5 988
type: UnificationXref
id: Q9Y5G5
db: uniprot

uniprot E1BMG4 1650
type: UnificationXref
id: E1BMG4
db: uniprot

uniprot A0A2I3SR38 1646
type: UnificationXref
id: A0A2I3SR38
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot G5EB64 2061
organism: Emericella nidulans

PP2A s133 sa118 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

Ebi
type: ProteinReference
xref: P01453
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Ebi
comment: ENTITY_REFERENCE_NOTES= Long Name: Ebi Synonym: IRA1 Accession: P01453
member entity reference: Q9QXE7
member entity reference: F-box-like/WD repeat-containing protein TBL1XR1
member entity reference: F-box-like/WD repeat-containing protein ebi
member entity reference: F-box-like/WD repeat-containing protein TBL1Y
member entity reference: H9H985
member entity reference: Transducin (Beta)-like 1X-linked receptor 1 (Predicted)
member entity reference: WD40 repeat-containing protein HOS15
member entity reference: Transducin (beta)-like 1 X-linked receptor 1
member entity reference: Transducin (beta)-like 1 X-linked receptor 1b
member entity reference: Uncharacterized protein
member entity reference: Transducin beta-like 1
member entity reference: A0A2I3TFS8
member entity reference: F7HNU9
member entity reference: O60907
member entity reference: Transducin (beta)-like 1 X-linked receptor 1a
member entity reference: F6S036
member entity reference: AGAP007739-PA
member entity reference: Transducin (Beta)-like 1 X-linked (Predicted)

Histone deacetylase s55 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Histone deacetylase
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot H9ZA60 1105
xref: PTHR10336:SF10
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r34 2444
type: Stoichiometry
physical entity: Beta Arrestin s12 a12
stoichiometric coefficient: 1.0

Protein kinase C eta type
type: ProteinReference
xref: uniprot Q64617 1703
xref: PTHR24356:SF192
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r34 2443
type: Stoichiometry
physical entity: Dishevelled
stoichiometric coefficient: 1.0

Pygopus 2
type: ProteinReference
xref: uniprot Q80V76 1913
xref: PTHR23194:SF7
organism: Mus musculus

Calcineurin B-like protein 4
type: ProteinReference
xref: PTHR23056:SF110
xref: uniprot O81223 1319
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r34 2445
type: Stoichiometry
physical entity: Complex Beta Arrestin Dishevelled s108 a227
stoichiometric coefficient: 1.0

uniprot A0A3Q1MSZ4 1375
type: UnificationXref
id: A0A3Q1MSZ4
db: uniprot

Frizzled class receptor 9
type: ProteinReference
xref: uniprot E2RAF3 79
xref: PTHR11309:SF79
organism: Canis lupus familiaris

uniprot I6YCF3 335
type: UnificationXref
id: I6YCF3
db: uniprot

uniprot P36575 1584
type: UnificationXref
id: P36575
db: uniprot

uniprot P50150 1961
type: UnificationXref
id: P50150
db: uniprot

uniprot F6V5K8 2054
type: UnificationXref
id: F6V5K8
db: uniprot

Calcineurin subunit B
type: ProteinReference
xref: uniprot P87072 1342
xref: PTHR45942:SF1
organism: Neurospora crassa

uniprot P97326 841
type: UnificationXref
id: P97326
db: uniprot

uniprot Q8BM92 891
type: UnificationXref
id: Q8BM92
db: uniprot

PTHR44156:SF2
type: RelationshipXref
id: PTHR44156:SF2
db: PANTHER Family
relationship type: By Homology

uniprot G3V6P8 1948
type: UnificationXref
id: G3V6P8
db: uniprot

uniprot A0A1D5QLF4 630
type: UnificationXref
id: A0A1D5QLF4
db: uniprot

uniprot P39962 1819
type: UnificationXref
id: P39962
db: uniprot

TCF
type: Protein
entity reference: TCF
feature: TCF s167 a383 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F7HTY2 321
type: UnificationXref
id: F7HTY2
db: uniprot

PTHR44156:SF9
type: RelationshipXref
id: PTHR44156:SF9
db: PANTHER Family
relationship type: By Homology

Casein kinase 1-like protein 12
type: ProteinReference
xref: PTHR11909:SF367
xref: uniprot Q8VYK9 1855
organism: Arabidopsis thaliana

uniprot Q969G3 427
type: UnificationXref
id: Q969G3
db: uniprot

Dishevelled s150 sa135 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.8230462015585855
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

C-terminal-binding protein 2
type: ProteinReference
xref: PTHR46029:SF3
xref: uniprot Q0VCQ1 612
organism: Bos taurus

Pi
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Serine45 Beta Catenin s82 sa52 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s82 sa52 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

CBP
type: ProteinReference
xref: P01448
standard name: CREB binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.CBP
comment: ENTITY_REFERENCE_NOTES= Long Name: CREB binding protein Synonym: CREB binding protein Accession: P01448
member entity reference: Histone acetyltransferase p300
member entity reference: CREB binding protein
member entity reference: Q9C5X9
member entity reference: Uncharacterized protein
member entity reference: Histone acetyltransferase HAC4
member entity reference: Q9FYH1
member entity reference: CREB-binding protein
member entity reference: E1A binding protein p300
member entity reference: Histone acetyltransferase HAC12
member entity reference: Histone acetyltransferase HAC5
member entity reference: Q09472
member entity reference: Protein cbp-1
member entity reference: P45481
member entity reference: CREB-binding protein isoform a

Uncharacterized protein
type: DnaReference
xref: PTHR46102:SF3
organism: Macaca mulatta

uniprot Q92997 1397
type: UnificationXref
id: Q92997
db: uniprot

uniprot B3DJ37 1036
type: UnificationXref
id: B3DJ37
db: uniprot

uniprot H9ENA3 1809
type: UnificationXref
id: H9ENA3
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 1617
xref: PTHR19850:SF27
organism: Bos taurus

Frizzled 8a protein
type: ProteinReference
xref: PTHR11309:SF140
xref: uniprot Q9YI00 153
organism: Danio rerio

DISSOCIATION LEFT Complex Adenomatous Polyposis Coli Axin PP2A Diversin Casein Kinase 1 Beta Catenin betaTrCP Glycogen Synthase Kinase 3Beta -RIGHT Complex betaTrCP Beta Catenin - Complex Adenomatous Polyposis Coli Axin Diversin Casein Kinase 1 Glycogen Synthase Kinase 3Beta PP2A - r91
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 2476
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 2474
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 2475
left: Complex (Adenomatous Polyposis Coli/Axin/ PP2A/Diversin/ Casein Kinase 1/Beta-Catenin/ betaTrCP/Glycogen Synthase Kinase-3Beta)
display name: DISSOCIATION_LEFT__Complex__Adenomatous_Polyposis_Coli_Axin__PP2A_Diversin__Casein_Kinase_1_Beta_Catenin__betaTrCP_Glycogen_Synthase_Kinase_3Beta_-RIGHT__Complex__betaTrCP_Beta_Catenin_-_Complex__Adenomatous_Polyposis_Coli_Axin__Diversin_Casein_Kinase_1__Glycogen_Synthase_Kinase_3Beta_PP2A_-_r91
interaction type: DISSOCIATION
right: Complex (Adenomatous Polyposis Coli/Axin/ Diversin/Casein Kinase 1/ Glycogen Synthase Kinase-3Beta/PP2A)
right: Complex (betaTrCP/Beta-Catenin)

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot A0A2I3RVR8 169
xref: PTHR46513:SF16
organism: Pan troglodytes

uniprot Q9YHE8 519
type: UnificationXref
id: Q9YHE8
db: uniprot

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: 224324

uniprot P43610 362
type: UnificationXref
id: P43610
db: uniprot

uniprot Q15172 580
type: UnificationXref
id: Q15172
db: uniprot

uniprot C3YYJ8 1146
type: UnificationXref
id: C3YYJ8
db: uniprot

uniprot A0NBC9 658
type: UnificationXref
id: A0NBC9
db: uniprot

uniprot A7EDU2 1598
type: UnificationXref
id: A7EDU2
db: uniprot

Threonine41 Beta Catenin s92 sa62 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s92 sa62 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

uniprot Q5U379 389
type: UnificationXref
id: Q5U379
db: uniprot

Brahma associated protein 111kD
type: ProteinReference
xref: PTHR46232:SF1
xref: uniprot Q9W384 449
organism: Drosophila melanogaster

Protocadherin 9
type: ProteinReference
xref: uniprot F1P7Y5 710
xref: PTHR24028:SF248
organism: Canis lupus familiaris

MYCN proto-oncogene, bHLH transcription factor
type: DnaReference
xref: PTHR45851:SF2
organism: Xenopus tropicalis

Protein Wnt-11
type: ProteinReference
xref: PTHR12027:SF7
xref: uniprot O96014 1219
organism: Homo sapiens

uniprot Q5TP56 1264
type: UnificationXref
id: Q5TP56
db: uniprot

uniprot P10523 1574
type: UnificationXref
id: P10523
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot A0A2I3S7X1 1032
organism: Pan troglodytes

uniprot O15943 802
type: UnificationXref
id: O15943
db: uniprot

uniprot P24723 1685
type: UnificationXref
id: P24723
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: PTHR13809:SF9
xref: uniprot Q28024 1975
organism: Bos taurus

DAG
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot F6XWE8 1938
organism: Monodelphis domestica

uniprot Q7Q6D3 1640
type: UnificationXref
id: Q7Q6D3
db: uniprot

uniprot F1P3H0 1044
type: UnificationXref
id: F1P3H0
db: uniprot

uniprot F6PG65 176
type: UnificationXref
id: F6PG65
db: uniprot

uniprot A0A1D5Q8S7 1295
type: UnificationXref
id: A0A1D5Q8S7
db: uniprot

uniprot P0CM54 1321
type: UnificationXref
id: P0CM54
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot Q06900 1077
organism: 9031

Protein phosphatase 2B
type: ProteinReference
xref: PTHR45942:SF1
xref: uniprot F1A1T3 1309
organism: Dictyostelium purpureum

uniprot H2QX07 1290
type: UnificationXref
id: H2QX07
db: uniprot

uniprot Q22227 1393
type: UnificationXref
id: Q22227
db: uniprot

uniprot F7E6I8 758
type: UnificationXref
id: F7E6I8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P802 711
xref: PTHR24028:SF260
organism: Canis lupus familiaris

uniprot H2QDQ1 1669
type: UnificationXref
id: H2QDQ1
db: uniprot

Protein L-Myc
type: DnaReference
xref: PTHR45851:SF5
organism: Mus musculus

uniprot Q9WTR5 969
type: UnificationXref
id: Q9WTR5
db: uniprot

uniprot F1MJS2 504
type: UnificationXref
id: F1MJS2
db: uniprot

Serine/threonine-protein kinase NLK
type: ProteinReference
xref: uniprot Q9UBE8 1430
xref: PTHR24055:SF380
organism: Homo sapiens

uniprot P19022 817
type: UnificationXref
id: P19022
db: uniprot

uniprot P48614 1242
type: UnificationXref
id: P48614
db: uniprot

uniprot Q9WU66 245
type: UnificationXref
id: Q9WU66
db: uniprot

uniprot F7GWP9 556
type: UnificationXref
id: F7GWP9
db: uniprot

E1A binding protein p400
type: ProteinReference
xref: PTHR46459:SF1
xref: uniprot H2R360 330
organism: Pan troglodytes

CTNNB1 isoform 2
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot H2R2U1 191
organism: Pan troglodytes

uniprot Q6PD28 589
type: UnificationXref
id: Q6PD28
db: uniprot

uniprot F1PVD5 714
type: UnificationXref
id: F1PVD5
db: uniprot

Chromatin structure-remodeling complex subunit snf21
type: ProteinReference
xref: uniprot Q9UTN6 445
xref: PTHR10799:SF854
organism: 284812

Protocadherin-like wing polarity protein stan
type: ProteinReference
xref: uniprot Q9V5N8 963
xref: PTHR24026:SF51
organism: Drosophila melanogaster

uniprot Q14643 43
type: UnificationXref
id: Q14643
db: uniprot

uniprot Q86UP0 889
type: UnificationXref
id: Q86UP0
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 16

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot A0A3Q1NGS8 1596
organism: Bos taurus

PTHR10799:SF541
type: RelationshipXref
id: PTHR10799:SF541
db: PANTHER Family
relationship type: By Homology

uniprot F6QAW3 87
type: UnificationXref
id: F6QAW3
db: uniprot

TCF7 isoform 6
type: ProteinReference
xref: PTHR10373:SF33
xref: uniprot A0A2I3SWP2 501
organism: Pan troglodytes

uniprot J9JHK9 1106
type: UnificationXref
id: J9JHK9
db: uniprot

T isoform 1
type: DnaReference
xref: PTHR11267:SF83
organism: Pan troglodytes

uniprot F6TM66 1910
type: UnificationXref
id: F6TM66
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Protein_Kinase_C-RIGHT__Protein_Kinase_C-_r76
controller: DAG

Protocadherin-18
type: ProteinReference
xref: PTHR24028:SF9
xref: uniprot Q9HCL0 941
organism: Homo sapiens

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
type: ProteinReference
xref: uniprot F1MTG9 289
xref: PTHR13844:SF1
organism: Bos taurus

TCF s57 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

uniprot F1M5T3 1907
type: UnificationXref
id: F1M5T3
db: uniprot

Beta Catenin s141 sa126 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta Catenin s141 sa126
stoichiometric coefficient: 1.0

uniprot O70437 1544
type: UnificationXref
id: O70437
db: uniprot

Complex (Beta-Catenin/Cadherin)
type: Complex
component stoichiometry: Cadherin s142 sa127 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Catenin s141 sa126 STOICHIOMETRY ID COMPLEX
component: Cadherin s142 sa127
component: Beta Catenin s141 sa126
feature: COMPLEX BINDING FEATURE s283 a592 2285
feature: COMPLEX BINDING FEATURE s283 a592 2283
cellular location: plasma membrane

uniprot A6H6X8 1138
type: UnificationXref
id: A6H6X8
db: uniprot

Cadherin related 23
type: ProteinReference
xref: PTHR24027:SF425
xref: uniprot A0A2I3RE49 633
organism: Pan troglodytes

uniprot P13677 1680
type: UnificationXref
id: P13677
db: uniprot

uniprot A0A1D5NX70 1127
type: UnificationXref
id: A0A1D5NX70
db: uniprot

Serine45 Beta Catenin s84 sa54 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s84 sa54 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

uniprot Q5FVA4 213
type: UnificationXref
id: Q5FVA4
db: uniprot

Threonine41 Beta Catenin s84 sa54 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s84 sa54 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

uniprot E2QX93 679
type: UnificationXref
id: E2QX93
db: uniprot

uniprot F7EZ48 100
type: UnificationXref
id: F7EZ48
db: uniprot

Transcription factor 7-like 1
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot Q9HCS4 514
organism: Homo sapiens

uniprot E2RHZ1 1721
type: UnificationXref
id: E2RHZ1
db: uniprot

Transcription factor 7 like 1
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot F7AIP6 509
organism: Monodelphis domestica

Axin s39 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

uniprot Q9JID2 1468
type: UnificationXref
id: Q9JID2
db: uniprot

uniprot Q9R216 147
type: UnificationXref
id: Q9R216
db: uniprot

uniprot Q9QZH0 146
type: UnificationXref
id: Q9QZH0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 1988
xref: PTHR13809:SF9
organism: Homo sapiens

uniprot F6TYA8 1383
type: UnificationXref
id: F6TYA8
db: uniprot

uniprot A4IFW0 1299
type: UnificationXref
id: A4IFW0
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot H2QAS6 1668
xref: PTHR24356:SF158
organism: Pan troglodytes

HETERODIMER_ASSOCIATION_LEFT__Frodo-_Complex__Beta_Arrestin_Dishevelled_-RIGHT__Complex__Dishevelled_Beta_Arrestin__Frodo_-_r35
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 2436
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 2435
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 2434
left: Complex Beta Arrestin Dishevelled s108 a227
left: Frodo s103 a212
interaction type: HETERODIMER_ASSOCIATION
right: Complex Dishevelled Beta Arrestin Frodo s107 a224

uniprot E2R792 2050
type: UnificationXref
id: E2R792
db: uniprot

Beta-arrestin-1
type: ProteinReference
xref: uniprot P49407 1585
xref: PTHR11792:SF22
organism: Homo sapiens

Peroxisome proliferator-activated receptor delta
type: DnaReference
xref: PTHR24082:SF15
organism: Homo sapiens

uniprot G3N2W8 102
type: UnificationXref
id: G3N2W8
db: uniprot

CDH18 isoform 2
type: ProteinReference
xref: PTHR24027:SF106
xref: uniprot H2QQP5 792
organism: Pan troglodytes

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot D4A0I8 1474
organism: Rattus norvegicus

CDH10 isoform 1
type: ProteinReference
xref: PTHR24027:SF290
xref: uniprot H2QQP7 793
organism: Pan troglodytes

uniprot B1WBV2 226
type: UnificationXref
id: B1WBV2
db: uniprot

Protein kinase family protein
type: ProteinReference
xref: uniprot Q9SQR8 1871
xref: PTHR11909:SF353
organism: Arabidopsis thaliana

Cadherin 9
type: ProteinReference
xref: PTHR24027:SF99
xref: uniprot H2QQP8 794
organism: Pan troglodytes

uniprot H9ZA60 1105
type: UnificationXref
id: H9ZA60
db: uniprot

AT-rich interaction domain 1A
type: ProteinReference
xref: PTHR12656:SF12
xref: uniprot E2RSH9 285
organism: Canis lupus familiaris

Cadherin-2
type: ProteinReference
xref: PTHR24027:SF79
xref: uniprot Q90275 904
organism: Danio rerio

ACTA1 isoform 1
type: DnaReference
xref: PTHR11937:SF193
organism: Pan troglodytes

Casein kinase 1-like protein 5
type: ProteinReference
xref: uniprot Q9ZUP4 1876
xref: PTHR11909:SF356
organism: Arabidopsis thaliana

uniprot F1NKC9 708
type: UnificationXref
id: F1NKC9
db: uniprot

Casein kinase II subunit beta-3
type: ProteinReference
xref: uniprot O81275 1740
xref: PTHR11740:SF22
organism: Arabidopsis thaliana

PTHR45659:SF15
type: RelationshipXref
id: PTHR45659:SF15
db: PANTHER Family
relationship type: By Homology

Transducin (beta)-like 1 X-linked receptor 1a
type: ProteinReference
xref: PTHR22846:SF40
xref: uniprot A0A2R9YJJ0 1490
organism: Danio rerio

PTHR45626:SF39
type: RelationshipXref
id: PTHR45626:SF39
db: PANTHER Family
relationship type: By Homology

uniprot J9P702 1955
type: UnificationXref
id: J9P702
db: uniprot

Transcription factor 7-like 1
type: DnaReference
xref: PTHR10373:SF25
organism: Mus musculus

Transcription factor 7-like 2
type: DnaReference
xref: PTHR10373:SF32
organism: Mus musculus

uniprot Q56I99 1553
type: UnificationXref
id: Q56I99
db: uniprot

Casein kinase II subunit beta-1
type: ProteinReference
xref: uniprot Q8TG12 1780
xref: PTHR11740:SF24
organism: Neurospora crassa

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot Q8TG13 1781
xref: PTHR24054:SF0
organism: Neurospora crassa

Casein kinase II subunit beta-2
type: ProteinReference
xref: uniprot Q8TG11 1779
xref: PTHR11740:SF0
organism: Neurospora crassa

G-protein beta subunit
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot Q5BH99 1633
organism: Emericella nidulans

uniprot Q9Y297 1530
type: UnificationXref
id: Q9Y297
db: uniprot

LRP5/6
type: Protein
entity reference: LRP5/6
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa7 2322
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5R6N7 524
type: UnificationXref
id: A0A1D5R6N7
db: uniprot

serine33 Beta Catenin s36 a37 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s36 a37 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

uniprot P23292 1815
type: UnificationXref
id: P23292
db: uniprot

Protocadherin beta-14
type: ProteinReference
xref: uniprot Q9Y5E9 977
xref: PTHR24028:SF81
organism: Homo sapiens

Protocadherin beta-15
type: ProteinReference
xref: PTHR24028:SF97
xref: uniprot Q9Y5E8 976
organism: Homo sapiens

Cadherin-7
type: ProteinReference
xref: PTHR24027:SF91
xref: uniprot Q8BM92 891
organism: Mus musculus

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF84
xref: uniprot P48729 1825
organism: Homo sapiens

PTHR11909:SF18
type: RelationshipXref
id: PTHR11909:SF18
db: PANTHER Family
relationship type: By Homology

SWI SNF s97 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SWI/SNF
stoichiometric coefficient: 1.0

uniprot O88689 810
type: UnificationXref
id: O88689
db: uniprot

uniprot F6R7X3 301
type: UnificationXref
id: F6R7X3
db: uniprot

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot P48730 1826
organism: Homo sapiens

Protocadherin beta-5
type: ProteinReference
xref: PTHR24028:SF90
xref: uniprot Q9Y5E4 972
organism: Homo sapiens

Protocadherin beta-4
type: ProteinReference
xref: PTHR24028:SF55
xref: uniprot Q9Y5E5 973
organism: Homo sapiens

uniprot Q9UBE8 1430
type: UnificationXref
id: Q9UBE8
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR45851:SF2
organism: Canis lupus familiaris

Protocadherin beta-3
type: ProteinReference
xref: PTHR24028:SF118
xref: uniprot Q9Y5E6 974
organism: Homo sapiens

Protocadherin beta-2
type: ProteinReference
xref: uniprot Q9Y5E7 975
xref: PTHR24028:SF281
organism: Homo sapiens

Protocadherin beta-7
type: ProteinReference
xref: PTHR24028:SF69
xref: uniprot Q9Y5E2 970
organism: Homo sapiens

Protocadherin beta-6
type: ProteinReference
xref: PTHR24028:SF104
xref: uniprot Q9Y5E3 971
organism: Homo sapiens

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: COMPLEX PARTICIPANT BINDING FEATURE s117 sa89 2192
feature: Serine45 Beta Catenin s117 sa89 rs1
feature: Threonine41 Beta Catenin s117 sa89 rs4
feature: serine33 Beta Catenin s117 sa89 rs3
feature: Beta Catenin s117 sa89 rs5
feature: Serine35 Beta Catenin s117 sa89 rs2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6Q910 299
type: UnificationXref
id: F6Q910
db: uniprot

uniprot E2RCX7 1534
type: UnificationXref
id: E2RCX7
db: uniprot

Cadherin EGF LAG seven-pass G-type receptor 2
type: ProteinReference
xref: uniprot A0A2I3TB47 642
xref: PTHR24026:SF32
organism: Pan troglodytes

CDH8 isoform 8
type: ProteinReference
xref: uniprot H2QB90 787
xref: PTHR24027:SF273
organism: Pan troglodytes

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot E2RA74 1039
organism: Canis lupus familiaris

Threonine41 Beta Catenin s36 a37 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s36 a37 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

Protein Wnt-11
type: ProteinReference
xref: uniprot P49339 1245
xref: PTHR12027:SF7
organism: 9031

uniprot H2QT14 562
type: UnificationXref
id: H2QT14
db: uniprot

Protein Wnt-4
type: ProteinReference
xref: uniprot P49337 1244
xref: PTHR12027:SF101
organism: 9031

Bcl9 s98 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Bcl9 s98 sa68
stoichiometric coefficient: 1.0

Serine35 Beta Catenin s138 sa123 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s138 sa123 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

uniprot Q9NYQ6 945
type: UnificationXref
id: Q9NYQ6
db: uniprot

uniprot F7E6Z1 759
type: UnificationXref
id: F7E6Z1
db: uniprot

ncbitaxon 7955 73
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot F7GVJ2 771
type: UnificationXref
id: F7GVJ2
db: uniprot

uniprot F1NHI6 1879
type: UnificationXref
id: F1NHI6
db: uniprot

AGAP004661-PA
type: DnaReference
xref: PTHR45659:SF15
organism: Anopheles gambiae

PTHR13808:SF1
type: RelationshipXref
id: PTHR13808:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q6JHU9 1412
type: UnificationXref
id: Q6JHU9
db: uniprot

uniprot K7AZD4 111
type: UnificationXref
id: K7AZD4
db: uniprot

G1/S-specific cyclin-D
type: DnaReference
xref: PTHR10177:SF203
organism: Caenorhabditis elegans

Protocadherin-9
type: ProteinReference
xref: uniprot Q9HC56 940
xref: PTHR24028:SF248
organism: Homo sapiens

Cadherin-20
type: ProteinReference
xref: PTHR24027:SF84
xref: uniprot Q9HBT6 939
organism: Homo sapiens

uniprot P22726 1228
type: UnificationXref
id: P22726
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot F6U298 1050
organism: Xenopus tropicalis

uniprot Q9Y5F3 981
type: UnificationXref
id: Q9Y5F3
db: uniprot

Arrestin, beta 1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot C3PTE8 1564
organism: Danio rerio

Diversin
type: Protein
entity reference: Diversin
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa28 2278
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Frizzled class receptor 8
type: ProteinReference
xref: PTHR11309:SF90
xref: uniprot F6VM33 94
organism: Xenopus tropicalis

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot Q6JHU9 1412
organism: Rattus norvegicus

Beta Catenin s100 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

Diversin s48 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Diversin
stoichiometric coefficient: 1.0

uniprot F1NLM6 542
type: UnificationXref
id: F1NLM6
db: uniprot

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot A0A2I3SXI2 1010
xref: PTHR24057:SF8
organism: Pan troglodytes

Casein kinase I isoform epsilon
type: ProteinReference
xref: uniprot Q9JMK2 1865
xref: PTHR11909:SF18
organism: Mus musculus

uniprot Q6PH57 1637
type: UnificationXref
id: Q6PH57
db: uniprot

Catenin alpha-2
type: ProteinReference
xref: PTHR18914:SF23
xref: uniprot Q61301 2035
organism: Mus musculus

Beta-arrestin-2
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot P32121 1583
organism: Homo sapiens

Actin, alpha skeletal muscle
type: DnaReference
xref: PTHR11937:SF193
organism: Rattus norvegicus

uniprot Q6VN51 1361
type: UnificationXref
id: Q6VN51
db: uniprot

Actin, alpha cardiac muscle 1
type: DnaReference
xref: PTHR11937:SF176
organism: Rattus norvegicus

Beta-arrestin-2
type: ProteinReference
xref: uniprot P32120 1582
xref: PTHR11792:SF20
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 41

Actin, gamma-enteric smooth muscle
type: DnaReference
xref: PTHR11937:SF201
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r86 2525
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Axin/PP2A/ Diversin/Casein Kinase 1)
stoichiometric coefficient: 1.0

uniprot Q6GLE6 586
type: UnificationXref
id: Q6GLE6
db: uniprot

PARTICIPANT STOICHIOMETRY r86 2526
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 3.0

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot K7B016 207
xref: PTHR45877:SF1
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r86 2527
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY r86 2528
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Glycogen Synthase Kinase-3Beta/Axin/ PP2A/Diversin/ Casein Kinase 1)
stoichiometric coefficient: 1.0

uniprot E1BJD1 276
type: UnificationXref
id: E1BJD1
db: uniprot

Os01g0570500 protein
type: ProteinReference
xref: PTHR11909:SF323
xref: uniprot Q656Y0 1841
organism: Oryza sativa

PTHR11909:SF20
type: RelationshipXref
id: PTHR11909:SF20
db: PANTHER Family
relationship type: By Homology

uniprot F7B9D1 1499
type: UnificationXref
id: F7B9D1
db: uniprot

uniprot F6TCQ4 1177
type: UnificationXref
id: F6TCQ4
db: uniprot

Cadherin-10
type: ProteinReference
xref: PTHR24027:SF290
xref: uniprot A0A1D5PYV2 626
organism: 9031

uniprot Q63811 1358
type: UnificationXref
id: Q63811
db: uniprot

uniprot O14641 1389
type: UnificationXref
id: O14641
db: uniprot

uniprot Q01970 1115
type: UnificationXref
id: Q01970
db: uniprot

Matrilysin
type: DnaReference
xref: PTHR10201:SF143
organism: Rattus norvegicus

Frodo s153 sa138 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Frodo s153 sa138
stoichiometric coefficient: 1.0

uniprot F7BDU6 1539
type: UnificationXref
id: F7BDU6
db: uniprot

uniprot A0A1D5QWF8 2044
type: UnificationXref
id: A0A1D5QWF8
db: uniprot

uniprot Q9WUD6 1285
type: UnificationXref
id: Q9WUD6
db: uniprot

Complex (Ebi/Siah-1)
type: Complex
component stoichiometry: Ebi s18 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Siah 1 s19 sa9 STOICHIOMETRY ID COMPLEX
component: Siah 1 s19 sa9
component: Ebi
feature: COMPLEX BINDING FEATURE s75 a136 2153
feature: COMPLEX BINDING FEATURE s75 a136 2151
cellular location: plasma membrane

Complex (Dishevelled/Beta-Arrestin/ Frodo/Casein Kinase 2)
type: Complex
component stoichiometry: Frodo s148 sa133 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Arrestin s147 sa132 STOICHIOMETRY ID COMPLEX
component stoichiometry: Dishevelled s146 sa131 STOICHIOMETRY ID COMPLEX
component stoichiometry: Casein Kinase 2 s149 sa134 STOICHIOMETRY ID COMPLEX
component: Beta-Arrestin
component: Casein Kinase 2
component: Frodo
component: Dishevelled
feature: COMPLEX BINDING FEATURE s288 a612 2299
feature: COMPLEX BINDING FEATURE s288 a612 2293
feature: COMPLEX BINDING FEATURE s288 a612 2295
feature: COMPLEX BINDING FEATURE s288 a612 2297
feature: ACTIVE 50
cellular location: plasma membrane

SWI SNF s104 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SWI/SNF
stoichiometric coefficient: 1.0

CDH5 isoform 1
type: ProteinReference
xref: uniprot A0A2J8MVE2 648
xref: PTHR24027:SF89
organism: Pan troglodytes

Pygopus 2
type: ProteinReference
xref: uniprot B5DFG8 1906
xref: PTHR23194:SF7
organism: Rattus norvegicus

uniprot Q7QCP8 1705
type: UnificationXref
id: Q7QCP8
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF82
xref: uniprot F1N5R1 1170
organism: Bos taurus

uniprot E1C2F7 277
type: UnificationXref
id: E1C2F7
db: uniprot

PARTICIPANT STOICHIOMETRY r101 2514
type: Stoichiometry
physical entity: Complex (Beta-Catenin/Cadherin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r101 2515
type: Stoichiometry
physical entity: Cadherin
stoichiometric coefficient: 1.0

PTHR11909:SF84
type: RelationshipXref
id: PTHR11909:SF84
db: PANTHER Family
relationship type: By Homology

uniprot Q9Y6F9 1286
type: UnificationXref
id: Q9Y6F9
db: uniprot

PARTICIPANT STOICHIOMETRY r103 2501
type: Stoichiometry
physical entity: Complex (Dishevelled/Beta-Arrestin/ Frodo/Casein Kinase 2)
stoichiometric coefficient: 1.0

uniprot F6Y191 738
type: UnificationXref
id: F6Y191
db: uniprot

uniprot Q969G9 60
type: UnificationXref
id: Q969G9
db: uniprot

PARTICIPANT STOICHIOMETRY r103 2502
type: Stoichiometry
physical entity: FRAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r103 2503
type: Stoichiometry
physical entity: Complex (Dishevelled/Casein Kinase 2/ Beta-Arrestin/Frodo/ FRAT)
stoichiometric coefficient: 1.0

CBP
type: Protein
entity reference: CBP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot Q9JMF3 1985
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r101 2516
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

uniprot H2QVA4 1205
type: UnificationXref
id: H2QVA4
db: uniprot

uniprot P04628 1221
type: UnificationXref
id: P04628
db: uniprot

ncbitaxon 64091 2000
type: UnificationXref
id: 64091
db: ncbitaxon

uniprot P53115 365
type: UnificationXref
id: P53115
db: uniprot

uniprot Q9UJ99 952
type: UnificationXref
id: Q9UJ99
db: uniprot

Myc proto-oncogene protein
type: DnaReference
xref: PTHR45851:SF1
organism: Rattus norvegicus

Protein S-Myc
type: DnaReference
xref: PTHR45851:SF4
organism: Rattus norvegicus

Wnt
type: Protein
entity reference: Wnt
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa6 2320
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 418

PI(4,5)P2
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9NHE2 1870
type: UnificationXref
id: Q9NHE2
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot F6Y8U0 157
organism: Macaca mulatta

uniprot F7H7P8 1193
type: UnificationXref
id: F7H7P8
db: uniprot

uniprot F7H6S1 1055
type: UnificationXref
id: F7H6S1
db: uniprot

Adenomatous Polyposis Coli
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s52 sa43 2288
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR11909:SF97
type: RelationshipXref
id: PTHR11909:SF97
db: PANTHER Family
relationship type: By Homology

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: 224308

uniprot E2RJB3 1926
type: UnificationXref
id: E2RJB3
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F6X3B2 1180
xref: PTHR12027:SF91
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MKL7 461
xref: PTHR10814:SF31
organism: Bos taurus

FrzB
type: Protein
entity reference: FrzB PROTEIN
comment: SPECIES_TYPE=PROTEIN

uniprot Q6PGB8 401
type: UnificationXref
id: Q6PGB8
db: uniprot

uniprot F6U824 305
type: UnificationXref
id: F6U824
db: uniprot

uniprot P48455 1333
type: UnificationXref
id: P48455
db: uniprot

uniprot P04426 1220
type: UnificationXref
id: P04426
db: uniprot

uniprot F6SSS3 1931
type: UnificationXref
id: F6SSS3
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot Q9VB23 596
organism: Drosophila melanogaster

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Caenorhabditis elegans

uniprot A0A2I3TB47 642
type: UnificationXref
id: A0A2I3TB47
db: uniprot

uniprot A0A2I3REF9 634
type: UnificationXref
id: A0A2I3REF9
db: uniprot

Protein Wnt-7b
type: ProteinReference
xref: PTHR12027:SF73
xref: uniprot P28047 1233
organism: Mus musculus

Beta Catenin s36 a37 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Tumor necrosis factor
type: DnaReference
xref: PTHR11471:SF23
organism: Homo sapiens

ADP
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Myosin-4
type: DnaReference
xref: PTHR45615:SF2
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR12802:SF9
xref: uniprot F6TQC1 304
organism: Monodelphis domestica

PTHR11909:SF72
type: RelationshipXref
id: PTHR11909:SF72
db: PANTHER Family
relationship type: By Homology

uniprot Q8T3S5 1778
type: UnificationXref
id: Q8T3S5
db: uniprot

uniprot P36898 1071
type: UnificationXref
id: P36898
db: uniprot

uniprot F1PJE5 1928
type: UnificationXref
id: F1PJE5
db: uniprot

Beta Catenin s76 sa40 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

uniprot F6X958 550
type: UnificationXref
id: F6X958
db: uniprot

G protein subunit beta 3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot H2R3A6 1616
organism: Pan troglodytes

uniprot P35221 2031
type: UnificationXref
id: P35221
db: uniprot

PTHR46342:SF1
type: RelationshipXref
id: PTHR46342:SF1
db: PANTHER Family
relationship type: By Homology

uniprot A0A2J8Q404 651
type: UnificationXref
id: A0A2J8Q404
db: uniprot

uniprot G3V7U3 1196
type: UnificationXref
id: G3V7U3
db: uniprot

TCF7 isoform 6
type: DnaReference
xref: PTHR10373:SF33
organism: Pan troglodytes

uniprot Q8R508 898
type: UnificationXref
id: Q8R508
db: uniprot

uniprot Q7FZF1 1364
type: UnificationXref
id: Q7FZF1
db: uniprot

Diversin
type: Protein
entity reference: Diversin
feature: COMPLEX PARTICIPANT BINDING FEATURE s191 sa106 2130
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P33146 820
type: UnificationXref
id: P33146
db: uniprot

uniprot H2REV2 1806
type: UnificationXref
id: H2REV2
db: uniprot

uniprot Q9R0T4 950
type: UnificationXref
id: Q9R0T4
db: uniprot

TCF s106 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

Complex (TCF/Beta-Catenin/ Smad4/Bcl9)
type: Complex
component stoichiometry: Beta Catenin s84 sa54 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCF s83 sa53 STOICHIOMETRY ID COMPLEX
component stoichiometry: Bcl9 s86 sa56 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smad4 s85 sa55 STOICHIOMETRY ID COMPLEX
component: Smad4
component: Bcl9
component: Beta Catenin s84 sa54
component: TCF
feature: COMPLEX BINDING FEATURE s179 a410 2265
feature: COMPLEX BINDING FEATURE s179 a410 2267
feature: COMPLEX BINDING FEATURE s179 a410 2269
feature: ACTIVE 50
feature: COMPLEX BINDING FEATURE s179 a410 2271
cellular location: nucleus

uniprot P27782 511
type: UnificationXref
id: P27782
db: uniprot

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 1
type: ProteinReference
xref: uniprot D3ZIE5 271
xref: PTHR10799:SF819
organism: Rattus norvegicus

Dishevelled segment polarity protein 3
type: ProteinReference
xref: uniprot F1PIB1 1382
xref: PTHR10878:SF6
organism: Canis lupus familiaris

Transducin like enhancer of split 1
type: ProteinReference
xref: uniprot H2R3C9 476
xref: PTHR10814:SF29
organism: Pan troglodytes

Axin 1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot F6XWP7 156
organism: Xenopus tropicalis

Endothelin-1
type: DnaReference
xref: PTHR13874:SF10
organism: Mus musculus

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Serine35 Beta Catenin s100 sa70 rs2
feature: Threonine41 Beta Catenin s100 sa70 rs4
feature: serine33 Beta Catenin s100 sa70 rs3
feature: Serine45 Beta Catenin s100 sa70 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 sa70 2164
feature: Beta Catenin s100 sa70 rs5
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

CDH3 isoform 2
type: ProteinReference
xref: PTHR24027:SF267
xref: uniprot H2QBE4 788
organism: Pan troglodytes

uniprot A0A2K6HNB9 652
type: UnificationXref
id: A0A2K6HNB9
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q04759 1696
organism: Homo sapiens

uniprot C3ZCG7 1149
type: UnificationXref
id: C3ZCG7
db: uniprot

Beta-transducin repeat containing E3 ubiquitin protein ligase
type: ProteinReference
xref: uniprot A0A1D5P3W6 1513
xref: PTHR44156:SF2
organism: 9031

Protocadherin 1
type: ProteinReference
xref: uniprot A0A2I3REF9 634
xref: PTHR24028:SF247
organism: Pan troglodytes

Catenin beta-1
type: ProteinReference
xref: uniprot Q0VCX4 195
xref: PTHR45976:SF4
organism: Bos taurus

Serine35 Beta Catenin s69 sa29 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s69 sa29 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

STATE_TRANSITION_LEFT__IP3_Gated_Calcium_Channel-RIGHT__IP3_Gated_Calcium_Channel-_r77
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 2409
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 2408
left: IP3 Gated Calcium Channel
interaction type: STATE_TRANSITION
right: IP3 Gated Calcium Channel

Smad4 s85 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smad4
stoichiometric coefficient: 1.0

GO GO:0005634 3
type: UnificationXref
id: GO:0005634
db: GO

STATE_TRANSITION_LEFT__NFAT-RIGHT__NFAT-_Pi-_r80
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 2386
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 2387
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 2385
left: NFAT
interaction type: STATE_TRANSITION
right: NFAT
right: Pi

ATP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6VET9 730
type: UnificationXref
id: F6VET9
db: uniprot

uniprot Q969F2 59
type: UnificationXref
id: Q969F2
db: uniprot

uniprot Q7G8Y3 405
type: UnificationXref
id: Q7G8Y3
db: uniprot

F-box/WD repeat-containing protein 1A
type: ProteinReference
xref: uniprot Q3ULA2 1526
xref: PTHR44156:SF2
organism: Mus musculus

uniprot H2R4F5 1480
type: UnificationXref
id: H2R4F5
db: uniprot

E3 ubiquitin-protein ligase SIAH2
type: ProteinReference
xref: uniprot O43255 208
organism: Homo sapiens

Protein Wnt-6
type: ProteinReference
xref: uniprot P22727 1229
xref: PTHR12027:SF72
organism: Mus musculus

Protein Wnt-5b
type: ProteinReference
xref: uniprot P22726 1228
xref: PTHR12027:SF87
organism: Mus musculus

Protein Wnt-5a
type: ProteinReference
xref: uniprot P22725 1227
xref: PTHR12027:SF33
organism: Mus musculus

Protein Wnt-4
type: ProteinReference
xref: uniprot P22724 1226
xref: PTHR12027:SF101
organism: Mus musculus

ncbitaxon 7668 199
type: UnificationXref
id: 7668
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6R7X3 301
xref: PTHR10799:SF879
organism: Monodelphis domestica

uniprot Q9Y5F7 983
type: UnificationXref
id: Q9Y5F7
db: uniprot

TLE family member 5
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot P63003 483
organism: Rattus norvegicus

TLE family member 5
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot P63002 482
organism: Mus musculus

uniprot H2R3C9 476
type: UnificationXref
id: H2R3C9
db: uniprot

uniprot G3V6L1 103
type: UnificationXref
id: G3V6L1
db: uniprot

uniprot F6PJR9 1172
type: UnificationXref
id: F6PJR9
db: uniprot

uniprot P63216 1971
type: UnificationXref
id: P63216
db: uniprot

uniprot Q74Z12 2089
type: UnificationXref
id: Q74Z12
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR22846:SF40
xref: uniprot F7B9D1 1499
organism: Macaca mulatta

uniprot Q13363 613
type: UnificationXref
id: Q13363
db: uniprot

Probable ATP-dependent DNA helicase CHR23
type: ProteinReference
xref: uniprot F4K128 297
xref: PTHR10799:SF854
organism: Arabidopsis thaliana

Predicted protein
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot A9THD0 1717
organism: Physcomitrella patens

uniprot Q9LTB8 1370
type: UnificationXref
id: Q9LTB8
db: uniprot

uniprot F1A421 1604
type: UnificationXref
id: F1A421
db: uniprot

Secreted frizzled related protein 2
type: ProteinReference
xref: PTHR11309:SF45
xref: uniprot F6Q2D0 229
organism: 9258

Histone deacetylase
type: ProteinReference
xref: uniprot Q0VC01 2080
xref: PTHR10625:SF203
organism: Bos taurus

uniprot P23287 1326
type: UnificationXref
id: P23287
db: uniprot

uniprot Q62441 493
type: UnificationXref
id: Q62441
db: uniprot

uniprot F1MVN1 1520
type: UnificationXref
id: F1MVN1
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF7
xref: uniprot F1N4C0 1169
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r98 2442
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Axin/PP2A)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r98 2441
type: Stoichiometry
physical entity: Complex (Siah-1/Ebi)
stoichiometric coefficient: 1.0

uniprot Q9BYE9 933
type: UnificationXref
id: Q9BYE9
db: uniprot

ncbitaxon 3055 1857
type: UnificationXref
id: 3055
db: ncbitaxon

Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1
type: ProteinReference
xref: uniprot O18178 565
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r98 2440
type: Stoichiometry
physical entity: Complex Adenomatous Polyposis Coli Beta Catenin Siah 1 Ebi Axin PP2A s275 a579
stoichiometric coefficient: 1.0

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Serine35 Beta Catenin s232 a380 rs2
feature: Beta Catenin s232 a380 rs5
feature: Serine45 Beta Catenin s232 a380 rs1
feature: ACTIVE 50
feature: serine33 Beta Catenin s232 a380 rs3
feature: Threonine41 Beta Catenin s232 a380 rs4
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P48453 1331
type: UnificationXref
id: P48453
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR24082:SF15
organism: Macaca mulatta

serine33 Beta Catenin s100 sa70 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s100 sa70 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

Casein Kinase 2
type: Protein
entity reference: Casein Kinase 2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 6

PARTICIPANT STOICHIOMETRY r77 2408
type: Stoichiometry
physical entity: IP3 Gated Calcium Channel
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r77 2409
type: Stoichiometry
physical entity: IP3 Gated Calcium Channel
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF70
xref: uniprot D4A3K6 1155
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR13844:SF5
xref: uniprot F6R7T1 300
organism: Monodelphis domestica

Wnt signaling pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Ebi-_Siah_1-RIGHT__Complex__Ebi_Siah_1_-_r21
pathway component: DISSOCIATION_LEFT__GTP-_Complex__G_Beta_Ggamma__Galpha_-RIGHT__GDP-_Galpha-_Complex__G_Beta_Ggamma_-_r74
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Wnt_Frizzled_-_LRP5_6-RIGHT__Complex__Frizzled_Wnt__LRP5_6_-_r5
pathway component: STATE_TRANSITION_LEFT__Casein_Kinase_1-RIGHT__Casein_Kinase_1-_re65
pathway component: STATE_TRANSITION_LEFT__IP3_Gated_Calcium_Channel-RIGHT__IP3_Gated_Calcium_Channel-_r77
pathway component: STATE_TRANSITION_LEFT__Complex__TCF_Smad4_-RIGHT__Complex__TCF_Smad4_-_re66
pathway component: STATE_TRANSITION_LEFT__ATP-_TCF-RIGHT__TCF-_ADP-_r69
pathway component: STATE_TRANSITION_LEFT__Wnt-RIGHT__Wnt-_re63
pathway component: STATE TRANSITION LEFT Complex Adenomatous Polyposis Coli Axin Diversin Beta Catenin PP2A - ATP-RIGHT ADP- Complex Adenomatous Polyposis Coli Beta Catenin Axin PP2A Diversin Casein Kinase 1 - r85
pathway component: STATE_TRANSITION_LEFT__Complex__Dishevelled_Beta_Arrestin__Frodo_-_ATP-RIGHT__ADP-_Complex__Dishevelled_Beta_Arrestin__Frodo_-_r104
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Axin_PP2A__Adenomatous_Polyposis_Coli_-_Beta_Catenin-RIGHT__Complex__Adenomatous_Polyposis_Coli_Axin__Beta_Catenin_PP2A_-_r47
pathway component: HETERODIMER_ASSOCIATION_LEFT__SWI_SNF-_Complex__Bcl9_Beta_Catenin__TCF_Smad4__Pygo_-RIGHT__Complex__Beta_Catenin_TCF__Smad4_Bcl9__Pygo_SWI__SNF_-_r66
pathway component: HETERODIMER ASSOCIATION LEFT CBP- Complex Beta Catenin TCF Smad4 Bcl9 Pygo SWI SNF -RIGHT Complex Bcl9 Pygo Beta Catenin SWI SNF CBP TCF Smad4 - r67
pathway component: HETERODIMER ASSOCIATION LEFT Complex Axin PP2A - Adenomatous Polyposis Coli-RIGHT Complex Axin PP2A Adenomatous Polyposis Coli - r46
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__TCF_Smad4_-_Beta_Catenin-RIGHT__Complex__TCF_Smad4__Beta_Catenin_-_r63
pathway component: DISSOCIATION_LEFT__Complex__Beta_Catenin_Cadherin_-RIGHT__Cadherin-_Beta_Catenin-_r101
pathway component: HETERODIMER_ASSOCIATION_LEFT__Frodo-_Complex__Beta_Arrestin_Dishevelled_-RIGHT__Complex__Dishevelled_Beta_Arrestin__Frodo_-_r35
pathway component: HETERODIMER_ASSOCIATION_LEFT__Kremen-_Dickkopf-RIGHT__Complex__Dickkopf_Kremen_-_r6
pathway component: STATE_TRANSITION_LEFT__Beta_Catenin-RIGHT__a146_degraded-_r23
pathway component: HETERODIMER ASSOCIATION LEFT Histone deacetylase- Transducin like Enhance of Split 1 3-RIGHT Complex Histone deacetylase Transducin like Enhance of Split 1 3 - r60
pathway component: STATE TRANSITION LEFT Complex Adenomatous Polyposis Coli Beta Catenin Axin PP2A Diversin Casein Kinase 1 - ATP-RIGHT ADP- Complex Adenomatous Polyposis Coli Beta Catenin Glycogen Synthase Kinase 3Beta Axin PP2A Diversin Casein Kinase 1 - r86
pathway component: TRANSCRIPTION_LEFT__NFAT_Target_Genes-RIGHT__NAFT_Target_Genes-_re68
pathway component: DISSOCIATION_LEFT__Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Axin_PP2A_-RIGHT__Complex__Adenomatous_Polyposis_Coli_Axin__PP2A_-_Beta_Catenin-_r99
pathway component: HETERODIMER_ASSOCIATION_LEFT__PP2A-_Axin-RIGHT__Complex__Axin_PP2A_-_r45
pathway component: HETERODIMER_ASSOCIATION_LEFT__Wnt-_Frizzled-RIGHT__Complex__Wnt_Frizzled_-_r1
pathway component: HETERODIMER ASSOCIATION LEFT betaTrCP- Complex Adenomatous Polyposis Coli Beta Catenin Glycogen Synthase Kinase 3Beta Axin PP2A Diversin Casein Kinase 1 -RIGHT Complex Adenomatous Polyposis Coli Axin PP2A Diversin Casein Kinase 1 Beta Catenin betaTrCP Glycogen Synthase Kinase 3Beta - r88
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Ebi_Siah_1_-_Complex__Adenomatous_Polyposis_Coli_Axin__Beta_Catenin_PP2A_-RIGHT__Complex__Adenomatous_Polyposis_Coli_Axin__PP2A_Beta_Catenin__Siah_1_Ebi_-_r54
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Dishevelled_Beta_Arrestin__Frodo_Casein_Kinase_2_-_FRAT-RIGHT__Complex__Dishevelled_Casein_Kinase_2__Beta_Arrestin_Frodo__FRAT_-_r103
pathway component: STATE_TRANSITION_LEFT__Beta_Catenin-RIGHT__a561_degraded-_r93
pathway component: STATE_TRANSITION_LEFT__Glycogen_Synthase_Kinase_3Beta-RIGHT__Glycogen_Synthase_Kinase_3Beta-_re69
pathway component: STATE_TRANSITION_LEFT__Calcineurin-RIGHT__Calcineurin-_r79
pathway component: DISSOCIATION_LEFT__Complex__Beta_Catenin_Cadherin__alpha_Catenin_-RIGHT__alpha_Catenin-_Complex__Beta_Catenin_Cadherin_-_r100
pathway component: STATE_TRANSITION_LEFT__NFAT-RIGHT__NFAT-_Pi-_r80
pathway component: STATE_TRANSITION_LEFT__Protein_Kinase_C-RIGHT__Protein_Kinase_C-_r76
pathway component: HETERODIMER_ASSOCIATION_LEFT__Bcl9-_Complex__TCF_Smad4__Beta_Catenin_-RIGHT__Complex__TCF_Beta_Catenin__Smad4_Bcl9_-_r64
pathway component: DISSOCIATION LEFT Complex Adenomatous Polyposis Coli Axin PP2A Diversin Casein Kinase 1 Beta Catenin betaTrCP Glycogen Synthase Kinase 3Beta -RIGHT Complex betaTrCP Beta Catenin - Complex Adenomatous Polyposis Coli Axin Diversin Casein Kinase 1 Glycogen Synthase Kinase 3Beta PP2A - r91
pathway component: TRANSCRIPTION_LEFT__Wnt_Target_Genes-RIGHT__Wnt_Target_Genes-_re67
pathway component: HETERODIMER_ASSOCIATION_LEFT__Casein_Kinase_2-_Complex__Dishevelled_Beta_Arrestin__Frodo_-RIGHT__Complex__Dishevelled_Beta_Arrestin__Frodo_Casein_Kinase_2_-_r102
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r111
pathway component: HETERODIMER ASSOCIATION LEFT Diversin- Complex Adenomatous Polyposis Coli Axin Beta Catenin PP2A -RIGHT Complex Adenomatous Polyposis Coli Axin Diversin Beta Catenin PP2A - r48
pathway component: STATE TRANSITION LEFT Nemo like Kinase- ATP-RIGHT ADP- Nemo like Kinase- r71
pathway component: HETERODIMER_ASSOCIATION_LEFT__Dishevelled-_Beta_Arrestin-RIGHT__Complex__Beta_Arrestin_Dishevelled_-_r34
pathway component: TRANSPORT LEFT NFAT-RIGHT NFAT- r109
pathway component: STATE TRANSITION LEFT Ubiquitin- Complex Adenomatous Polyposis Coli Axin PP2A Diversin Casein Kinase 1 Beta Catenin betaTrCP Glycogen Synthase Kinase 3Beta -RIGHT Complex Adenomatous Polyposis Coli Axin PP2A Diversin Casein Kinase 1 Beta Catenin betaTrCP Glycogen Synthase Kinase 3Beta - r90
pathway component: STATE_TRANSITION_LEFT__Ubiquitin-_Complex__Adenomatous_Polyposis_Coli_Axin__PP2A_Beta_Catenin__Siah_1_Ebi_-RIGHT__Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Siah_1_Ebi__Axin_PP2A_-_r96
pathway component: TRANSPORT_LEFT__Nemo_like_Kinase-RIGHT__Nemo_like_Kinase-_r108
pathway component: HETERODIMER ASSOCIATION LEFT Pygo- Complex TCF Beta Catenin Smad4 Bcl9 -RIGHT Complex Bcl9 Beta Catenin TCF Smad4 Pygo - r65
pathway component: TRANSPORT_LEFT__Wnt-RIGHT__Wnt-_r107
pathway component: DISSOCIATION_LEFT__Complex__betaTrCP_Beta_Catenin_-RIGHT__Beta_Catenin-_betaTrCP-_r92
pathway component: HETERODIMER_ASSOCIATION_LEFT__Smad4-_TCF-RIGHT__Complex__TCF_Smad4_-_r59
pathway component: STATE_TRANSITION_LEFT__Dishevelled-RIGHT__Dishevelled-_re64
pathway component: TRANSPORT LEFT Beta Catenin-RIGHT Beta Catenin- r58
pathway component: DISSOCIATION_LEFT__PI_4,5_P2-RIGHT__DAG-_IP3-_r110
pathway component: DISSOCIATION_LEFT__Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Siah_1_Ebi__Axin_PP2A_-RIGHT__Complex__Siah_1_Ebi_-_Complex__Adenomatous_Polyposis_Coli_Beta_Catenin__Axin_PP2A_-_r98
pathway component: HETERODIMER_ASSOCIATION_LEFT__Phospholipase_C-_Galpha-RIGHT__Complex__Galpha_Phospholipase_C_-_r72
xref: PANTHER Pathway P00057 1
comment: MODEL_NOTES=Panther Pathway: P00057 The secreted protein Wnt activates the heptahelical receptor Frizzled on nieghboring cells. Activation of Frizzled causes the recruitment of additional membrane proteins which in turn result in 1) the activation of the protein Dishevelled via phosphorylation and 2) the activation of a heterotrimeric G protein of unknown type. Activation of Dishevelled results in the down-regulation of the Beta-Catenin destruction complex which causes ubiquitination of Beta-Catenin and its ultimate degradation via the proteasome. Inhibition of the Beta-Catenin destruction complex yields a higher cytosolic concentration of Beta-Catenin, which enters the nucleus, binds various transcriptional regulatory molecules including the TCF/LEF class of proteins, and results in the transcription of TCF/LEF target genes. Activation of the heterotrimeric G-protein pathway in turn activates Phospholipase C which in turn catalyzes the catalysis of PI(4,5)P2 into DAG and IP3. Medline=12356903 Medline=12573432 Website=http://www.biocarta.com/pathfiles/h_wntPathway.asp Website=http://www.infobiogen.fr/services/chromcancer/Deep/WNTsignPathID20042.html PMID: 12356903 PMID: 12573432

ncbitaxon 45351 1712
type: UnificationXref
id: 45351
db: ncbitaxon

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa36 2184
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot O96999 1814
type: UnificationXref
id: O96999
db: uniprot

Protocadherin Fat 2
type: ProteinReference
xref: PTHR24026:SF37
xref: uniprot O88277 808
organism: Rattus norvegicus

Cadherin EGF LAG seven-pass G-type receptor 3
type: ProteinReference
xref: uniprot O88278 809
xref: PTHR24026:SF38
organism: Rattus norvegicus

AGAP002123-PA
type: ProteinReference
xref: uniprot Q7PYV4 167
organism: Anopheles gambiae

uniprot F1N4C0 1169
type: UnificationXref
id: F1N4C0
db: uniprot

Tumor necrosis factor
type: DnaReference
xref: PTHR11471:SF23
organism: Canis lupus familiaris

PTHR11267:SF169
type: RelationshipXref
id: PTHR11267:SF169
db: PANTHER Family
relationship type: By Homology

S-arrestin
type: ProteinReference
xref: PTHR11792:SF15
xref: uniprot P08168 1572
organism: Bos taurus

uniprot F1PPK6 1045
type: UnificationXref
id: F1PPK6
db: uniprot

STATE_TRANSITION_LEFT__ATP-_TCF-RIGHT__TCF-_ADP-_r69
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 2429
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 2430
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 2428
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 2427
left: ATP
left: TCF
interaction type: STATE_TRANSITION
right: TCF
right: ADP

uniprot F6YV22 605
type: UnificationXref
id: F6YV22
db: uniprot

Frizzled class receptor 10
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot Q9W6E3 152
organism: Danio rerio

uniprot H2QIU8 1060
type: UnificationXref
id: H2QIU8
db: uniprot

uniprot A7Z019 268
type: UnificationXref
id: A7Z019
db: uniprot

Frizzled-related protein
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot Q9W6E0 1893
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot H3FT78 1807
organism: 54126

uniprot H2R9U6 235
type: UnificationXref
id: H2R9U6
db: uniprot

Serine45 Beta Catenin s117 sa89 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s117 sa89 rs1 Serine45
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

Cadherin 5
type: ProteinReference
xref: uniprot F1M7E5 699
xref: PTHR24027:SF89
organism: Rattus norvegicus

Histone deacetylase 7
type: ProteinReference
xref: PTHR10625:SF194
xref: uniprot Q9FH09 2101
organism: Arabidopsis thaliana

Axin 1
type: ProteinReference
xref: uniprot H2R1H5 158
xref: PTHR46102:SF3
organism: Pan troglodytes

Axin-1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot A0A1D5P395 154
organism: 9031

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF87
xref: uniprot F6XUZ7 1183
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR12802:SF105
xref: uniprot A0A3Q1LWF7 256
organism: Bos taurus

uniprot Q96GM5 428
type: UnificationXref
id: Q96GM5
db: uniprot

serine33 Beta Catenin s84 sa54 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s84 sa54 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

uniprot B7ZC77 2010
type: UnificationXref
id: B7ZC77
db: uniprot

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot P08182 1744
organism: Drosophila melanogaster

Cadherin 11
type: ProteinReference
xref: uniprot F1P6U6 709
xref: PTHR24027:SF85
organism: Canis lupus familiaris

Casein kinase II subunit alpha
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot P08181 1743
organism: Drosophila melanogaster

uniprot Q05471 372
type: UnificationXref
id: Q05471
db: uniprot

Protein mom-5
type: ProteinReference
xref: uniprot A0A0K3AWM6 63
xref: PTHR11309:SF47
organism: Caenorhabditis elegans

Predicted protein
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot A9SBU0 1714
organism: Physcomitrella patens

uniprot O14905 1215
type: UnificationXref
id: O14905
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot F7HRY3 1385
organism: Macaca mulatta

uniprot P29992 1456
type: UnificationXref
id: P29992
db: uniprot

CSNK2A1 isoform 3
type: ProteinReference
xref: uniprot K7D8P4 1735
xref: PTHR24054:SF16
organism: Pan troglodytes

Transducin-like enhancer protein 6
type: ProteinReference
xref: uniprot Q9WVB3 498
xref: PTHR10814:SF2
organism: Mus musculus

Transducin-like enhancer protein 2
type: ProteinReference
xref: PTHR10814:SF4
xref: uniprot Q9WVB2 497
organism: Mus musculus

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: uniprot Q9WVB9 1399
xref: PTHR10878:SF5
organism: Rattus norvegicus

uniprot A0A2I3SSC7 5
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F6TU68 1535
xref: PTHR13703:SF23
organism: Monodelphis domestica

GBeta
type: Protein
entity reference: GBeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s158 sa80 2140
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P36408 1623
type: UnificationXref
id: P36408
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 1602
xref: PTHR19850:SF28
organism: Canis lupus familiaris

uniprot O81445 1320
type: UnificationXref
id: O81445
db: uniprot

Diversin
type: Protein
entity reference: Diversin
feature: COMPLEX PARTICIPANT BINDING FEATURE s181 sa98 2114
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QLH3 1030
organism: Macaca mulatta

Casein kinase I
type: ProteinReference
xref: uniprot Q8IHZ9 1849
xref: PTHR11909:SF18
organism: 36329

uniprot Q5QMY9 1835
type: UnificationXref
id: Q5QMY9
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot E2R2S3 1922
organism: Canis lupus familiaris

Adenomatous Polyposis Coli s66 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot F6R812 1799
organism: Monodelphis domestica

uniprot Q38D21 1765
type: UnificationXref
id: Q38D21
db: uniprot

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot Q2QLE7 1261
organism: Pan troglodytes

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 26

Nemo-like Kinase
type: Protein
entity reference: Nemo-like Kinase
feature: Nemo like Kinase s199 a451 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7G1U7 1448
organism: Monodelphis domestica

uniprot Q66KC9 2003
type: UnificationXref
id: Q66KC9
db: uniprot

Transducin-like Enhance of Split 1-3
type: Protein
entity reference: Transducin-like Enhance of Split 1-3
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa49 2222
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Adenomatous Polyposis Coli
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s127 sa113 2204
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot D3ZTI3 665
type: UnificationXref
id: D3ZTI3
db: uniprot

uniprot P18266 1018
type: UnificationXref
id: P18266
db: uniprot

Cadherin-2
type: ProteinReference
xref: uniprot P15116 816
xref: PTHR24027:SF79
organism: Mus musculus

Secreted frizzled-related protein 2
type: ProteinReference
xref: PTHR11309:SF45
xref: uniprot Q96HF1 242
organism: Homo sapiens

uniprot A0A3Q1MM63 527
type: UnificationXref
id: A0A3Q1MM63
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F1P714 543
xref: PTHR10257:SF89
organism: Canis lupus familiaris

uniprot F6XII5 1937
type: UnificationXref
id: F6XII5
db: uniprot

Adenomatous Polyposis Coli s187 sa103 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli
stoichiometric coefficient: 1.0

PTHR10814:SF24
type: RelationshipXref
id: PTHR10814:SF24
db: PANTHER Family
relationship type: By Homology

PTHR10814:SF21
type: RelationshipXref
id: PTHR10814:SF21
db: PANTHER Family
relationship type: By Homology

Histone deacetylase
type: ProteinReference
xref: uniprot Q7K6A1 2091
xref: PTHR10625:SF132
organism: 36329

PTHR10814:SF29
type: RelationshipXref
id: PTHR10814:SF29
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot F1N4K7 84
organism: Bos taurus

uniprot Q9VFX1 1284
type: UnificationXref
id: Q9VFX1
db: uniprot

uniprot Q9Y5G2 986
type: UnificationXref
id: Q9Y5G2
db: uniprot

uniprot H2QQB0 234
type: UnificationXref
id: H2QQB0
db: uniprot

Siah 1 s130 sa115 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Siah-1
stoichiometric coefficient: 1.0

Ebi s22 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ebi s22 sa11
stoichiometric coefficient: 1.0

PTHR10814:SF31
type: RelationshipXref
id: PTHR10814:SF31
db: PANTHER Family
relationship type: By Homology

uniprot P39038 824
type: UnificationXref
id: P39038
db: uniprot

Smad4 s80 sa51 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smad4
stoichiometric coefficient: 1.0

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot F7HC75 1666
organism: Macaca mulatta

Dishevelled s23 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dishevelled
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Casein_Kinase_1-RIGHT__Casein_Kinase_1-_re65
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re65 2500
participant stoichiometry: PARTICIPANT STOICHIOMETRY re65 2499
left: Casein Kinase 1
interaction type: STATE_TRANSITION
right: Casein Kinase 1

Wnt
type: Protein
entity reference: Wnt
feature: ACTIVE 50
comment: SPECIES_TYPE=PROTEIN

Frizzled-related protein
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot B2GUW1 1877
organism: Rattus norvegicus

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot A1Z7L8 1034
organism: Drosophila melanogaster

uniprot B3DIG4 75
type: UnificationXref
id: B3DIG4
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot A0A2I3RSP9 1297
organism: Pan troglodytes

Adenylosuccinate synthetase
type: DnaReference
xref: PTHR11846:SF0
organism: Pseudomonas aeruginosa

uniprot F1MA46 700
type: UnificationXref
id: F1MA46
db: uniprot

uniprot Q802C8 412
type: UnificationXref
id: Q802C8
db: uniprot

Beta-Arrestin
type: Protein
entity reference: Beta-Arrestin
feature: COMPLEX PARTICIPANT BINDING FEATURE s144 sa129 2336
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Casein Kinase 2 s149 sa134 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Casein Kinase 2
stoichiometric coefficient: 1.0

Serine45 Beta Catenin s111 sa83 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s111 sa83 rs1 Serine45
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

uniprot F1MYW8 1927
type: UnificationXref
id: F1MYW8
db: uniprot

SWF/SNF family helicase
type: ProteinReference
xref: uniprot Q8RDV9 417
xref: PTHR10799:SF923
organism: Fusobacterium nucleatum

C-terminal-binding protein 1
type: ProteinReference
xref: uniprot Q20595 615
xref: PTHR46029:SF7
organism: Caenorhabditis elegans

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s137 sa122 2368
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Beta Catenin s138 sa123 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

uniprot A7SG27 1711
type: UnificationXref
id: A7SG27
db: uniprot

Histone acetyltransferase HAC5
type: ProteinReference
xref: PTHR13808:SF30
xref: uniprot Q9LE42 1417
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot F7FPX9 1804
organism: Monodelphis domestica

uniprot Q9V9W8 1916
type: UnificationXref
id: Q9V9W8
db: uniprot

uniprot P70288 2078
type: UnificationXref
id: P70288
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 30

uniprot H2QQP5 792
type: UnificationXref
id: H2QQP5
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 48

Siah-1
type: Protein
entity reference: Siah 1 PROTEIN
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6S9J1 1048
type: UnificationXref
id: F6S9J1
db: uniprot

Cadherin 6, type 2, K-cadherin (Fetal kidney)
type: ProteinReference
xref: PTHR24027:SF322
xref: uniprot H2R1Q6 801
organism: Pan troglodytes

Complex (G_Beta/Ggamma)
type: Complex
component stoichiometry: Ggamma s160 sa81 STOICHIOMETRY ID COMPLEX
component stoichiometry: GBeta s158 sa80 STOICHIOMETRY ID COMPLEX
component: GBeta
component: Ggamma
feature: COMPLEX BINDING FEATURE s215 a478 2139
feature: COMPLEX BINDING FEATURE s215 a478 2141
feature: ACTIVE 50
cellular location: plasma membrane

uniprot E2REK7 684
type: UnificationXref
id: E2REK7
db: uniprot

Adenylosuccinate synthetase isozyme 2
type: DnaReference
xref: PTHR11846:SF13
organism: Pan troglodytes

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Beta Catenin s135 sa120 rs5
feature: COMPLEX PARTICIPANT BINDING FEATURE s135 sa120 2364
feature: Threonine41 Beta Catenin s135 sa120 rs4
feature: Serine45 Beta Catenin s135 sa120 rs1
feature: Serine35 Beta Catenin s135 sa120 rs2
feature: serine33 Beta Catenin s135 sa120 rs3
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q99PF4 932
type: UnificationXref
id: Q99PF4
db: uniprot

uniprot O94281 1741
type: UnificationXref
id: O94281
db: uniprot

uniprot Q965X6 223
type: UnificationXref
id: Q965X6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF484
xref: uniprot Q4H358 1428
organism: 7719

uniprot F6Y5X3 740
type: UnificationXref
id: F6Y5X3
db: uniprot

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot F1MSQ2 1042
organism: Bos taurus

sFRP
type: ProteinReference
xref: P01434
standard name: secreted frizzled-related protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.sFRP
comment: ENTITY_REFERENCE_NOTES= Long Name: secreted frizzled-related protein Synonym: Synonym not specified Accession: P01434
member entity reference: Secreted frizzled-related protein 5
member entity reference: F7ESJ0
member entity reference: Q3SX29
member entity reference: Secreted frizzled-related protein 2
member entity reference: Secreted frizzled-related protein 1
member entity reference: D3ZTV6
member entity reference: F7GHD3
member entity reference: Secreted frizzled related protein 2
member entity reference: SFRP2 isoform 1
member entity reference: SFRP1 isoform 1

Serine/threonine-protein kinase receptor
type: ProteinReference
xref: uniprot H2QPW8 1061
organism: Pan troglodytes

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot E2RB53 1013
xref: PTHR24057:SF8
organism: Canis lupus familiaris

Mothers against decapentaplegic homolog
type: ProteinReference
xref: PTHR13703:SF23
xref: uniprot H2QQ88 1543
organism: Pan troglodytes

uniprot D3ZCR1 1150
type: UnificationXref
id: D3ZCR1
db: uniprot

PTHR10799:SF854
type: RelationshipXref
id: PTHR10799:SF854
db: PANTHER Family
relationship type: By Homology

uniprot P97305 1483
type: UnificationXref
id: P97305
db: uniprot

SMARCA5 isoform 1
type: ProteinReference
xref: uniprot H2QQ80 326
xref: PTHR10799:SF879
organism: Pan troglodytes

PTHR10799:SF856
type: RelationshipXref
id: PTHR10799:SF856
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5P3W6 1513
type: UnificationXref
id: A0A1D5P3W6
db: uniprot

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 2001

MCG141285
type: ProteinReference
xref: uniprot Q91UZ8 907
xref: PTHR24028:SF58
organism: Mus musculus

Matrilysin
type: DnaReference
xref: PTHR10201:SF143
organism: Homo sapiens

uniprot C3XQF4 536
type: UnificationXref
id: C3XQF4
db: uniprot

Cadherin 2
type: ProteinReference
xref: PTHR24027:SF79
xref: uniprot A0A2I3TU99 645
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot H2Q1D9 1952
organism: Pan troglodytes

uniprot Q9W6E3 152
type: UnificationXref
id: Q9W6E3
db: uniprot

uniprot H2QNS5 1615
type: UnificationXref
id: H2QNS5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P52287 1624
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q91UZ1 1118
organism: Mus musculus

Glycogen synthase kinase-3 beta isoform 1
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot H9EPM1 1016
organism: Macaca mulatta

uniprot O84559 348
type: UnificationXref
id: O84559
db: uniprot

Os01g0198200 protein
type: ProteinReference
xref: PTHR11909:SF395
xref: uniprot Q5QMY9 1835
organism: Oryza sativa

uniprot H2QMI4 325
type: UnificationXref
id: H2QMI4
db: uniprot

uniprot Q60848 393
type: UnificationXref
id: Q60848
db: uniprot

uniprot F6R543 19
type: UnificationXref
id: F6R543
db: uniprot

uniprot A0A1D5RJQ0 1471
type: UnificationXref
id: A0A1D5RJQ0
db: uniprot

ncbitaxon 9606 41
type: UnificationXref
id: 9606
db: ncbitaxon

PTHR10799:SF879
type: RelationshipXref
id: PTHR10799:SF879
db: PANTHER Family
relationship type: By Homology

PCDH10 isoform 2
type: ProteinReference
xref: PTHR24028:SF0
xref: uniprot H2QQ62 791
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot F7G1K7 1447
organism: Monodelphis domestica

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F1M7Y5 1655
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Beta_Catenin-RIGHT__a146_degraded-_r23
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 2518
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 2517
left: Beta-Catenin
interaction type: STATE_TRANSITION
right: a146 degraded s81 a148

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot Q92793 1413
organism: Homo sapiens

Cadherin 11
type: ProteinReference
xref: uniprot F6XVG8 737
xref: PTHR24027:SF85
organism: Monodelphis domestica

Casein kinase 1-like protein 6
type: ProteinReference
xref: uniprot Q8LPJ1 1852
xref: PTHR11909:SF316
organism: Arabidopsis thaliana

Histone deacetylase 8
type: ProteinReference
xref: uniprot Q0VCB2 2081
xref: PTHR10625:SF109
organism: Bos taurus

Frizzled
type: Protein
entity reference: Frizzled
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q28DV3 2083
type: UnificationXref
id: Q28DV3
db: uniprot

Casein kinase 1-like protein 4
type: ProteinReference
xref: PTHR11909:SF97
xref: uniprot Q8LPI7 1851
organism: Arabidopsis thaliana

uniprot Q6PDG5 400
type: UnificationXref
id: Q6PDG5
db: uniprot

uniprot F7EFL9 1435
type: UnificationXref
id: F7EFL9
db: uniprot

uniprot F1MAA3 540
type: UnificationXref
id: F1MAA3
db: uniprot

TRANSCRIPTION
type: InteractionVocabulary

Cadherin 18
type: ProteinReference
xref: PTHR24027:SF106
xref: uniprot E9Q9Q6 691
organism: Mus musculus

Beta Catenin s117 sa89 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

Protocadherin 10
type: ProteinReference
xref: uniprot E9PXQ7 689
xref: PTHR24028:SF0
organism: Mus musculus

Protein Wnt-2
type: ProteinReference
xref: uniprot Q2QL96 1260
xref: PTHR12027:SF86
organism: Monodelphis domestica

uniprot P70407 837
type: UnificationXref
id: P70407
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot G5EBH0 1102
organism: Caenorhabditis elegans

PTHR10799:SF819
type: RelationshipXref
id: PTHR10799:SF819
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r1 2412
type: Stoichiometry
physical entity: Complex (Wnt/Frizzled)
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2B catalytic subunit
type: ProteinReference
xref: uniprot Q05681 1344
xref: PTHR45673:SF1
organism: Neurospora crassa

PARTICIPANT STOICHIOMETRY r1 2410
type: Stoichiometry
physical entity: Wnt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 2411
type: Stoichiometry
physical entity: Frizzled
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E2R263 1495
xref: PTHR22846:SF40
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF25
xref: uniprot Q6DF43 1979
organism: Xenopus tropicalis

Axin
type: Protein
entity reference: Axin
feature: COMPLEX PARTICIPANT BINDING FEATURE s112 sa84 2378
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

ISWI chromatin-remodeling complex ATPase CHR11
type: ProteinReference
xref: uniprot Q8RWY3 419
xref: PTHR10799:SF879
organism: Arabidopsis thaliana

uniprot Q9UN73 960
type: UnificationXref
id: Q9UN73
db: uniprot

uniprot F7GFF0 766
type: UnificationXref
id: F7GFF0
db: uniprot

Adenylosuccinate synthetase 1, chloroplastic
type: DnaReference
xref: PTHR11846:SF0
organism: Oryza sativa

uniprot Q9JIP6 142
type: UnificationXref
id: Q9JIP6
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot Q9WV60 1027
xref: PTHR24057:SF8
organism: Mus musculus

uniprot B3S653 532
type: UnificationXref
id: B3S653
db: uniprot

Cadherin-3
type: ProteinReference
xref: uniprot P10287 813
xref: PTHR24027:SF267
organism: Mus musculus

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 443

uniprot B6V8E6 185
type: UnificationXref
id: B6V8E6
db: uniprot

uniprot Q5WN07 391
type: UnificationXref
id: Q5WN07
db: uniprot

Cadherin-2
type: ProteinReference
xref: PTHR24027:SF79
xref: uniprot P10288 814
organism: 9031

uniprot P67874 1760
type: UnificationXref
id: P67874
db: uniprot

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 1997

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF208
xref: uniprot Q5B6M4 2087
organism: Emericella nidulans

Chromatin remodeling protein
type: ProteinReference
xref: uniprot Q8IIW0 415
xref: PTHR10799:SF879
organism: 36329

ARRB1 isoform 1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot H2R1Z2 1571
organism: Pan troglodytes

Serine35 Beta Catenin s84 sa54 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s84 sa54 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

uniprot K7E376 1957
type: UnificationXref
id: K7E376
db: uniprot

uniprot F6SV99 92
type: UnificationXref
id: F6SV99
db: uniprot

Histone deacetylase 2
type: ProteinReference
xref: uniprot Q92769 2098
xref: PTHR10625:SF203
organism: Homo sapiens

Homeobox protein engrailed-like
type: DnaReference
xref: PTHR24341:SF5
organism: Pan troglodytes

uniprot E2R858 682
type: UnificationXref
id: E2R858
db: uniprot

uniprot O13298 2066
type: UnificationXref
id: O13298
db: uniprot

uniprot Q0P594 576
type: UnificationXref
id: Q0P594
db: uniprot

Serine45 Beta Catenin s260 a561 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s260 a561 rs1 Serine45
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

Secreted frizzled-related protein 3
type: ProteinReference
xref: uniprot Q92765 1890
xref: PTHR11309:SF97
organism: Homo sapiens

uniprot Q550R6 386
type: UnificationXref
id: Q550R6
db: uniprot

uniprot P36896 1069
type: UnificationXref
id: P36896
db: uniprot

Protein Wnt-10b
type: ProteinReference
xref: uniprot P48614 1242
xref: PTHR12027:SF76
organism: Mus musculus

PTHR24082:SF15
type: RelationshipXref
id: PTHR24082:SF15
db: PANTHER Family
relationship type: By Homology

Protein Wnt-11
type: ProteinReference
xref: uniprot P48615 1243
xref: PTHR12027:SF7
organism: Mus musculus

uniprot F7AQR3 1445
type: UnificationXref
id: F7AQR3
db: uniprot

uniprot Q6DF43 1979
type: UnificationXref
id: Q6DF43
db: uniprot

uniprot P19534 818
type: UnificationXref
id: P19534
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QLF4 630
xref: PTHR24027:SF323
organism: Macaca mulatta

uniprot B0S6S2 74
type: UnificationXref
id: B0S6S2
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot F6YMS3 1537
xref: PTHR13703:SF36
organism: Macaca mulatta

uniprot P19784 1748
type: UnificationXref
id: P19784
db: uniprot

Cadherin-3
type: ProteinReference
xref: PTHR24028:SF146
xref: uniprot P34616 823
organism: Caenorhabditis elegans

uniprot Q4H358 1428
type: UnificationXref
id: Q4H358
db: uniprot

Beta-arrestin-2
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot P29067 1581
organism: Rattus norvegicus

Beta-arrestin-1
type: ProteinReference
xref: uniprot P29066 1580
xref: PTHR11792:SF22
organism: Rattus norvegicus

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 1595
xref: PTHR19850:SF27
organism: Pan troglodytes

uniprot A0A3S5ZP89 263
type: UnificationXref
id: A0A3S5ZP89
db: uniprot

PTHR11740:SF0
type: RelationshipXref
id: PTHR11740:SF0
db: PANTHER Family
relationship type: By Homology

MCG1033322
type: ProteinReference
xref: uniprot Q91V48 908
xref: PTHR24028:SF98
organism: Mus musculus

uniprot A8X8Y1 1792
type: UnificationXref
id: A8X8Y1
db: uniprot

uniprot P45481 1410
type: UnificationXref
id: P45481
db: uniprot

Beta-transducin repeat-containing E3 ubiquitin protein ligase
type: ProteinReference
xref: PTHR19849:SF1
xref: uniprot F6XVN5 1521
organism: Xenopus tropicalis

PTHR11740:SF5
type: RelationshipXref
id: PTHR11740:SF5
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3SSM9 500
type: UnificationXref
id: A0A2I3SSM9
db: uniprot

STATE_TRANSITION_LEFT__Calcineurin-RIGHT__Calcineurin-_r79
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 2400
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 2401
left: Calcineurin
interaction type: STATE_TRANSITION
right: Calcineurin

Frizzled 7a
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot Q8QFM3 137
organism: Danio rerio

uniprot H2QQ62 791
type: UnificationXref
id: H2QQ62
db: uniprot

Threonine41 Beta Catenin s141 sa126 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s141 sa126 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

Casein kinase II subunit alpha
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot Q02720 1762
organism: Dictyostelium discoideum

Casein kinase 1 delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot F6TBG4 1800
organism: 9258

Complex (TCF/Smad4)
type: Complex
component stoichiometry: TCF s57 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smad4 s58 sa47 STOICHIOMETRY ID COMPLEX
component: Smad4 s58 sa47
component: TCF
feature: COMPLEX BINDING FEATURE s174 a392 2245
feature: COMPLEX BINDING FEATURE s174 a392 2247
feature: ACTIVE 50
cellular location: nucleus

uniprot H8ESF3 333
type: UnificationXref
id: H8ESF3
db: uniprot

Calcineurin subunit B type 1
type: ProteinReference
xref: uniprot P63099 1338
xref: PTHR45942:SF3
organism: Bos taurus

Calcineurin subunit B type 1
type: ProteinReference
xref: uniprot P63098 1337
xref: PTHR45942:SF3
organism: Homo sapiens

PTHR44129:SF4
type: RelationshipXref
id: PTHR44129:SF4
db: PANTHER Family
relationship type: By Homology

GBeta s158 sa80 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBeta
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Beta_Catenin-RIGHT__a561_degraded-_r93
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 2467
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 2466
left: Beta-Catenin
interaction type: STATE_TRANSITION
right: a561_degraded

AGAP001944-PA
type: ProteinReference
xref: PTHR19855:SF12
xref: uniprot Q7PYH7 1528
organism: Anopheles gambiae

uniprot F7EW26 2059
type: UnificationXref
id: F7EW26
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: DISSOCIATION_LEFT__GTP-_Complex__G_Beta_Ggamma__Galpha_-RIGHT__GDP-_Galpha-_Complex__G_Beta_Ggamma_-_r74
control type: ACTIVATION
controller: Complex (Frizzled/Wnt/ LRP5/6)

uniprot P15887 1576
type: UnificationXref
id: P15887
db: uniprot

uniprot Q7Q5Q8 1588
type: UnificationXref
id: Q7Q5Q8
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot K7BA21 1107
xref: PTHR10336:SF12
organism: Pan troglodytes

uniprot H2QEX8 475
type: UnificationXref
id: H2QEX8
db: uniprot

Calcineurin subunit B
type: ProteinReference
xref: uniprot Q9UU93 1372
xref: PTHR45942:SF1
organism: 284812

Beta Catenin s82 sa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

uniprot A0A2I3SSA4 254
type: UnificationXref
id: A0A2I3SSA4
db: uniprot

Protocadherin 18
type: ProteinReference
xref: uniprot F7EKI5 760
xref: PTHR24028:SF9
organism: Rattus norvegicus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q05655 1698
organism: Homo sapiens

uniprot Q967X2 1784
type: UnificationXref
id: Q967X2
db: uniprot

uniprot P48456 1334
type: UnificationXref
id: P48456
db: uniprot

uniprot Q7PUT1 407
type: UnificationXref
id: Q7PUT1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot P63078 1966
organism: Mus musculus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF7
xref: uniprot Q9I9I2 1277
organism: Danio rerio

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 1965
xref: PTHR13809:SF19
organism: Rattus norvegicus

Probable global transcription activator SNF2L1
type: ProteinReference
xref: PTHR10799:SF819
xref: uniprot P28370 356
organism: Homo sapiens

uniprot F7GHD3 233
type: UnificationXref
id: F7GHD3
db: uniprot

uniprot Q9Z2F5 618
type: UnificationXref
id: Q9Z2F5
db: uniprot

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Threonine41 Beta Catenin s260 a561 rs4
feature: serine33 Beta Catenin s260 a561 rs3
feature: Serine45 Beta Catenin s260 a561 rs1
feature: Serine35 Beta Catenin s260 a561 rs2
feature: Beta Catenin s260 a561 rs5
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q1RLQ4 614
type: UnificationXref
id: Q1RLQ4
db: uniprot

uniprot F1LMI3 692
type: UnificationXref
id: F1LMI3
db: uniprot

uniprot Q8W1K7 1856
type: UnificationXref
id: Q8W1K7
db: uniprot

Cadherin 1, type 1, E-cadherin (epithelial)
type: ProteinReference
xref: uniprot A0A0R4IFF8 622
xref: PTHR24027:SF319
organism: Danio rerio

uniprot Q9Y5I0 1002
type: UnificationXref
id: Q9Y5I0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MSU2 1476
xref: PTHR12533:SF6
organism: Bos taurus

uniprot F6WBD5 189
type: UnificationXref
id: F6WBD5
db: uniprot

uniprot Q967F4 928
type: UnificationXref
id: Q967F4
db: uniprot

Casein Kinase 1 s192 sa107 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Casein Kinase 1
stoichiometric coefficient: 1.0

uniprot F7GJC2 767
type: UnificationXref
id: F7GJC2
db: uniprot

uniprot F1MDC9 1656
type: UnificationXref
id: F1MDC9
db: uniprot

uniprot A0A2I3SWP2 501
type: UnificationXref
id: A0A2I3SWP2
db: uniprot

dishevelled homolog
type: ProteinReference
xref: PTHR10878:SF25
xref: uniprot Q9NL46 1398
organism: 7719

uniprot Q99JE6 1119
type: UnificationXref
id: Q99JE6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3S5ZP89 263
xref: PTHR10799:SF879
organism: 9031

uniprot F7FJQ1 2060
type: UnificationXref
id: F7FJQ1
db: uniprot

Cadherin-23
type: ProteinReference
xref: uniprot Q9H251 938
xref: PTHR24027:SF425
organism: Homo sapiens

G1/S-specific cyclin-D1
type: DnaReference
xref: PTHR10177:SF67
organism: Homo sapiens

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot Q5ACW5 1767
xref: PTHR11740:SF24
organism: Candida albicans

Protein kinase C beta type
type: ProteinReference
xref: uniprot A8KBH6 1648
xref: PTHR24356:SF158
organism: Xenopus tropicalis

uniprot H2QAS6 1668
type: UnificationXref
id: H2QAS6
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot H2Q194 1199
xref: PTHR12027:SF75
organism: Pan troglodytes

uniprot F6VEV5 731
type: UnificationXref
id: F6VEV5
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Smad4-_TCF-RIGHT__Complex__TCF_Smad4_-_r59
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 2489
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 2488
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 2490
left: Smad4
left: TCF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TCF/Smad4)

PP2A s113 sa85 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

uniprot Q9VJC2 1872
type: UnificationXref
id: Q9VJC2
db: uniprot

Cadherin 17
type: ProteinReference
xref: PTHR24027:SF419
xref: uniprot A0A2I3RTC9 637
organism: Pan troglodytes

uniprot P16054 1681
type: UnificationXref
id: P16054
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF149
xref: uniprot Q9XWB7 1122
organism: Caenorhabditis elegans

uniprot A0A3Q2U4M7 1419
type: UnificationXref
id: A0A3Q2U4M7
db: uniprot

uniprot Q6PD03 588
type: UnificationXref
id: Q6PD03
db: uniprot

uniprot Q14332 122
type: UnificationXref
id: Q14332
db: uniprot

Ankrd6 protein
type: ProteinReference
xref: uniprot B5DEH9 1991
xref: PTHR24203:SF7
organism: Rattus norvegicus

Frizzled class receptor 6
type: ProteinReference
xref: uniprot H2R2C6 109
xref: PTHR11309:SF75
organism: Pan troglodytes

Protein Wnt-5a
type: ProteinReference
xref: uniprot P41221 1239
xref: PTHR12027:SF33
organism: Homo sapiens

uniprot A9SBU0 1714
type: UnificationXref
id: A9SBU0
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR10201:SF143
organism: Macaca mulatta

Ggamma
type: Protein
entity reference: G gamma PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s162 sa78 2348
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7F580 1945
type: UnificationXref
id: F7F580
db: uniprot

AT-rich interaction domain 1A
type: ProteinReference
xref: PTHR12656:SF12
xref: uniprot D4A3E3 272
organism: Rattus norvegicus

Transducin (beta)-like 1 X-linked receptor 1
type: ProteinReference
xref: uniprot F6WUH3 1498
xref: PTHR22846:SF40
organism: Xenopus tropicalis

Actin, cytoplasmic 1
type: DnaReference
xref: PTHR11937:SF477
organism: Xenopus tropicalis

uniprot F6Z5R3 2057
type: UnificationXref
id: F6Z5R3
db: uniprot

SFRP2 isoform 1
type: ProteinReference
xref: PTHR11309:SF45
xref: uniprot H2QQB0 234
organism: Pan troglodytes

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 1336

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
type: ProteinReference
xref: uniprot Q61466 394
xref: PTHR13844:SF1
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2XJE9 1426
xref: PTHR24055:SF380
organism: Bos taurus

Phospholipase C
type: Protein
entity reference: Phospholipase C
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P12830 815
type: UnificationXref
id: P12830
db: uniprot

uniprot H8WGV2 29
type: UnificationXref
id: H8WGV2
db: uniprot

uniprot H9EP27 1810
type: UnificationXref
id: H9EP27
db: uniprot

Protein naked cuticle homolog 2
type: ProteinReference
xref: PTHR22611:SF1
xref: uniprot Q969F2 59
organism: Homo sapiens

PP2A
type: Protein
entity reference: PP2A
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa20 2304
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P15116 816
type: UnificationXref
id: P15116
db: uniprot

Calcineurin subunit B type 1
type: ProteinReference
xref: uniprot P63100 1339
xref: PTHR45942:SF3
organism: Rattus norvegicus

Cadherin
type: Protein
entity reference: Cadherin
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein Wnt
type: ProteinReference
xref: uniprot F6TCQ4 1177
xref: PTHR12027:SF82
organism: Xenopus tropicalis

uniprot E1BAM8 671
type: UnificationXref
id: E1BAM8
db: uniprot

uniprot F1P3Q4 292
type: UnificationXref
id: F1P3Q4
db: uniprot

uniprot D4ADV8 1378
type: UnificationXref
id: D4ADV8
db: uniprot

Casein kinase 1-like protein 7
type: ProteinReference
xref: PTHR11909:SF366
xref: uniprot Q9FFH8 1864
organism: Arabidopsis thaliana

uniprot P62872 1628
type: UnificationXref
id: P62872
db: uniprot

uniprot P70227 39
type: UnificationXref
id: P70227
db: uniprot

Threonine41 Beta Catenin s69 sa29 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s69 sa29 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
type: ProteinReference
xref: PTHR46232:SF2
xref: uniprot Q969G3 427
organism: Homo sapiens

Gnb2 protein
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot Q5BJ11 1634
organism: Danio rerio

Cadherin-20
type: ProteinReference
xref: PTHR24027:SF84
xref: uniprot Q8QGH3 896
organism: 9031

Protein naked cuticle homolog 1
type: ProteinReference
xref: uniprot Q969G9 60
xref: PTHR22611:SF2
organism: Homo sapiens

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 354

Myc proto-oncogene protein
type: DnaReference
xref: PTHR45851:SF1
organism: Bos taurus

Smad4
type: Protein
entity reference: Smad4
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 35

uniprot Q8R490 897
type: UnificationXref
id: Q8R490
db: uniprot

uniprot P56517 2074
type: UnificationXref
id: P56517
db: uniprot

Segmentation polarity homeobox protein engrailed
type: DnaReference
xref: PTHR24341:SF7
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR46029:SF3
xref: uniprot F7HTC6 606
organism: Macaca mulatta

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
type: ProteinReference
xref: uniprot H2R0D2 328
xref: PTHR10019:SF5
organism: Pan troglodytes

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 1638
xref: PTHR19850:SF30
organism: Anopheles gambiae

Protein Wnt
type: ProteinReference
xref: uniprot F6XGB0 1181
xref: PTHR12027:SF86
organism: 9258

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot Q7TNL5 591
xref: PTHR10257:SF89
organism: Mus musculus

Serine45 Beta Catenin s135 sa120 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s135 sa120 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

uniprot A0A2I3RW11 52
type: UnificationXref
id: A0A2I3RW11
db: uniprot

uniprot H2QXN7 2025
type: UnificationXref
id: H2QXN7
db: uniprot

uniprot Q5DRD7 862
type: UnificationXref
id: Q5DRD7
db: uniprot

uniprot Q5KAC2 1356
type: UnificationXref
id: Q5KAC2
db: uniprot

uniprot F6U055 506
type: UnificationXref
id: F6U055
db: uniprot

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
type: ProteinReference
xref: uniprot Q5BIN2 388
xref: PTHR10019:SF5
organism: Bos taurus

uniprot F7HSM1 558
type: UnificationXref
id: F7HSM1
db: uniprot

ncbitaxon 1111708 369
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot A0A1D5R774 454
type: UnificationXref
id: A0A1D5R774
db: uniprot

Frodo
type: Protein
entity reference: Frodo PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa14 2332
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR45851:SF5
type: RelationshipXref
id: PTHR45851:SF5
db: PANTHER Family
relationship type: By Homology

PTHR45851:SF4
type: RelationshipXref
id: PTHR45851:SF4
db: PANTHER Family
relationship type: By Homology

PTHR45851:SF3
type: RelationshipXref
id: PTHR45851:SF3
db: PANTHER Family
relationship type: By Homology

Beta Catenin s88 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta Catenin s88 sa58
stoichiometric coefficient: 1.0

PTHR45851:SF2
type: RelationshipXref
id: PTHR45851:SF2
db: PANTHER Family
relationship type: By Homology

Protein Wnt-8a
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot Q9H1J5 1275
organism: Homo sapiens

Protein Wnt-5b
type: ProteinReference
xref: uniprot Q9H1J7 1276
xref: PTHR12027:SF87
organism: Homo sapiens

PTHR45851:SF6
type: RelationshipXref
id: PTHR45851:SF6
db: PANTHER Family
relationship type: By Homology

Protocadherin 10
type: ProteinReference
xref: uniprot F1M6B6 696
xref: PTHR24028:SF0
organism: Rattus norvegicus

IP3 Gated Calcium Channel
type: Protein
entity reference: IP3 Gated Calcium Channel
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot Q7TSK3 887
type: UnificationXref
id: Q7TSK3
db: uniprot

uniprot Q9P2W3 1987
type: UnificationXref
id: Q9P2W3
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 22

Actin, cytoplasmic type 5
type: DnaReference
xref: PTHR11937:SF168
organism: 9031

PTHR45851:SF1
type: RelationshipXref
id: PTHR45851:SF1
db: PANTHER Family
relationship type: By Homology

DEAD/DEAH box helicase, putative
type: ProteinReference
xref: uniprot O96239 351
xref: PTHR10799:SF854
organism: 36329

uniprot Q7PUW9 881
type: UnificationXref
id: Q7PUW9
db: uniprot

uniprot Q99JR8 430
type: UnificationXref
id: Q99JR8
db: uniprot

Cadherin 18
type: ProteinReference
xref: PTHR24027:SF106
xref: uniprot F6Y5X3 740
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q5KAC2 1356
xref: PTHR45673:SF1
organism: 214684

Axin s132 sa117 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

Dishevelled s143 sa128 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.8230462015585855
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot O43318 1064
organism: Homo sapiens

uniprot Q14517 846
type: UnificationXref
id: Q14517
db: uniprot

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
type: ProteinReference
xref: uniprot Q99JR8 430
xref: PTHR13844:SF2
organism: Mus musculus

uniprot Q9UU93 1372
type: UnificationXref
id: Q9UU93
db: uniprot

uniprot P33151 821
type: UnificationXref
id: P33151
db: uniprot

uniprot P97299 237
type: UnificationXref
id: P97299
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot F6Q1E0 1930
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Protein_Kinase_C-RIGHT__Protein_Kinase_C-_r76
controller: Ca2 PLUS s294 a618

Dickkopf s6 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dickkopf
stoichiometric coefficient: 1.0

SMARCAL1 isoform 1
type: ProteinReference
xref: PTHR45766:SF3
xref: uniprot H2R0H8 329
organism: Pan troglodytes

Predicted protein
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot A9T4Y7 1716
organism: Physcomitrella patens

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E1BMG4 1650
organism: Bos taurus

uniprot H2L011 2023
type: UnificationXref
id: H2L011
db: uniprot

Protein Wnt-8b
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot Q9WUD6 1285
organism: Mus musculus

uniprot O81223 1319
type: UnificationXref
id: O81223
db: uniprot

Protein phospatase 3 regulatory subunit B alpha isoform type 1
type: ProteinReference
xref: PTHR45942:SF1
xref: uniprot Q6VN50 1360
organism: Xenopus tropicalis

uniprot O95813 1292
type: UnificationXref
id: O95813
db: uniprot

Protein phospatase 3 regulatory subunit B alpha isoform type 1
type: ProteinReference
xref: PTHR45942:SF1
xref: uniprot Q6VN51 1361
organism: 9031

C-terminal binding protein 1
type: ProteinReference
xref: uniprot F1P620 602
xref: PTHR46029:SF2
organism: Canis lupus familiaris

IP3 Gated Calcium Channel
type: Protein
entity reference: IP3 Gated Calcium Channel
feature: ACTIVE 50
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Serine35 Beta Catenin s184 sa100 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s184 sa100 2118
feature: Threonine41 Beta Catenin s184 sa100 rs4
feature: Serine45 Beta Catenin s184 sa100 rs1
feature: Beta Catenin s184 sa100 rs5
feature: serine33 Beta Catenin s184 sa100 rs3
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Frizzled s4 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Frizzled
stoichiometric coefficient: 1.0

uniprot F7EXZ6 762
type: UnificationXref
id: F7EXZ6
db: uniprot

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot P21868 1749
xref: PTHR24054:SF16
organism: 9031

PTHR10878:SF24
type: RelationshipXref
id: PTHR10878:SF24
db: PANTHER Family
relationship type: By Homology

PTHR10878:SF25
type: RelationshipXref
id: PTHR10878:SF25
db: PANTHER Family
relationship type: By Homology

Protein S-Myc
type: DnaReference
xref: PTHR45851:SF4
organism: Mus musculus

uniprot F6Q1Z2 298
type: UnificationXref
id: F6Q1Z2
db: uniprot

Histone deacetylase 8
type: ProteinReference
xref: PTHR10625:SF109
xref: uniprot Q9BY41 2100
organism: Homo sapiens

Cadherin 18
type: ProteinReference
xref: PTHR24027:SF106
xref: uniprot F1M702 697
organism: Rattus norvegicus

uniprot P34889 1237
type: UnificationXref
id: P34889
db: uniprot

Dishevelled s146 sa131 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.8230462015585855
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot B2GUW1 1877
type: UnificationXref
id: B2GUW1
db: uniprot

PTHR24026:SF76
type: RelationshipXref
id: PTHR24026:SF76
db: PANTHER Family
relationship type: By Homology

Protein cbp-1
type: ProteinReference
xref: uniprot P34545 1409
xref: PTHR13808:SF1
organism: Caenorhabditis elegans

PTHR24026:SF75
type: RelationshipXref
id: PTHR24026:SF75
db: PANTHER Family
relationship type: By Homology

uniprot Q9Y6M4 1875
type: UnificationXref
id: Q9Y6M4
db: uniprot

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: uniprot Q9I8V2 1557
xref: PTHR13703:SF23
organism: Danio rerio

uniprot A0A2J8ND39 649
type: UnificationXref
id: A0A2J8ND39
db: uniprot

Casein kinase I isoform epsilon
type: ProteinReference
xref: uniprot P49674 1827
xref: PTHR11909:SF18
organism: Homo sapiens

Axin s47 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

Glycogen Synthase Kinase 3Beta s186 sa102 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glycogen Synthase Kinase-3Beta
stoichiometric coefficient: 1.0

uniprot H2QJA9 107
type: UnificationXref
id: H2QJA9
db: uniprot

uniprot Q9UKB1 1529
type: UnificationXref
id: Q9UKB1
db: uniprot

FZD10 protein
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot A3KMX5 69
organism: Bos taurus

Wnt
type: ProteinReference
xref: P01444
standard name: Wingless-type MMTV integration site family member
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Wingless-type MMTV integration site family member Synonym: Wingless Accession: P01444
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Wnt
member entity reference: Protein Wnt
member entity reference: Protein Wnt-7a
member entity reference: Protein Wnt-5b
member entity reference: Protein Wnt-10a
member entity reference: P56705
member entity reference: Q9QYS1
member entity reference: Abnormal cell lineage protein 44
member entity reference: F6PJR9
member entity reference: Protein Wnt-2
member entity reference: Protein Wnt-1
member entity reference: H2QD96
member entity reference: Protein Wnt-6
member entity reference: Protein Wnt-10b
member entity reference: Q9QXQ7
member entity reference: Protein CBR-CWN-2
member entity reference: Protein Wnt-8b
member entity reference: Protein mom-2
member entity reference: Protein Wnt-11
member entity reference: P56706
member entity reference: Protein Wnt-9a
member entity reference: P04426
member entity reference: Proto-oncogene Wnt-1
member entity reference: P09544
member entity reference: Protein Wnt-4
member entity reference: H2Q4F7
member entity reference: Protein Wnt-7b
member entity reference: Wnt inhibitor of Dorsal protein
member entity reference: H2Q2F4
member entity reference: H2Q569
member entity reference: C3YYJ8
member entity reference: Protein Wnt-8a
member entity reference: Protein Wnt-4a
member entity reference: D3ZFS0
member entity reference: Protein CBR-EGL-20
member entity reference: P56704
member entity reference: Protein Wnt-11b-1

uniprot Q9ULW2 149
type: UnificationXref
id: Q9ULW2
db: uniprot

Beta Catenin s88 sa58 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

uniprot F7FMS7 763
type: UnificationXref
id: F7FMS7
db: uniprot

Kremen
type: ProteinReference
xref: P01463
comment: ENTITY_REFERENCE_NOTES= Long Name: Kremen Synonym: Synonym not specified Accession: P01463
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.RECEPTOR.Kremen
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Kremen protein 1
member entity reference: Kringle containing transmembrane protein 1
member entity reference: Q99N43
member entity reference: Kremen protein 2
member entity reference: Kremen protein
member entity reference: Q96MU8
member entity reference: H2R709
member entity reference: D4ADS5

uniprot P56519 2076
type: UnificationXref
id: P56519
db: uniprot

PTHR24026:SF97
type: RelationshipXref
id: PTHR24026:SF97
db: PANTHER Family
relationship type: By Homology

uniprot Q9V393 1594
type: UnificationXref
id: Q9V393
db: uniprot

uniprot P56703 1249
type: UnificationXref
id: P56703
db: uniprot

uniprot O75197 180
type: UnificationXref
id: O75197
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 1604
xref: PTHR19850:SF25
organism: Dictyostelium purpureum

Axin
type: Protein
entity reference: Axin
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa27 2276
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR24026:SF93
type: RelationshipXref
id: PTHR24026:SF93
db: PANTHER Family
relationship type: By Homology

Dishevelled s38 sa16 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.8230462015585855
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: uniprot Q8K120 1487
xref: PTHR12533:SF11
organism: Mus musculus

Actin alpha 2, smooth muscle
type: DnaReference
xref: PTHR11937:SF445
organism: Danio rerio

uniprot K9J7P6 564
type: UnificationXref
id: K9J7P6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR22846:SF40
xref: uniprot A0A2I3SYP1 1488
organism: Pan troglodytes

uniprot P51029 1247
type: UnificationXref
id: P51029
db: uniprot

ncbitaxon 321614 1348
type: UnificationXref
id: 321614
db: ncbitaxon

PTHR24026:SF89
type: RelationshipXref
id: PTHR24026:SF89
db: PANTHER Family
relationship type: By Homology

uniprot H2Q9Q1 474
type: UnificationXref
id: H2Q9Q1
db: uniprot

uniprot Q22944 380
type: UnificationXref
id: Q22944
db: uniprot

Serine35 Beta Catenin s36 a37 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s36 a37 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

uniprot F1MJ55 1726
type: UnificationXref
id: F1MJ55
db: uniprot

PARTICIPANT STOICHIOMETRY r63 2465
type: Stoichiometry
physical entity: Complex (TCF/Smad4/ Beta-Catenin)
stoichiometric coefficient: 1.0

uniprot P10288 814
type: UnificationXref
id: P10288
db: uniprot

uniprot P49407 1585
type: UnificationXref
id: P49407
db: uniprot

uniprot Q8W5G9 1782
type: UnificationXref
id: Q8W5G9
db: uniprot

PARTICIPANT STOICHIOMETRY r63 2463
type: Stoichiometry
physical entity: Complex (TCF/Smad4)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 2464
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

uniprot P36897 1070
type: UnificationXref
id: P36897
db: uniprot

uniprot A0A3Q1LZX5 257
type: UnificationXref
id: A0A3Q1LZX5
db: uniprot

uniprot F1A1T3 1309
type: UnificationXref
id: F1A1T3
db: uniprot

TCF
type: ProteinReference
xref: P01437
standard name: T-Cell Transcription Factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.TCF
comment: ENTITY_REFERENCE_NOTES= Long Name: T cell factor Synonym: LEF,Lymphocyte Enhance Binding Factor,Pangolin,T Cell Factor Accession: P01437
member entity reference: Transcription factor 7-like 2
member entity reference: F6U055
member entity reference: Transcription factor 7 like 1
member entity reference: Lymphoid enhancer binding factor 1
member entity reference: Uncharacterized protein
member entity reference: Transcription factor 7-like 1
member entity reference: Lymphocyte enhancer binding factor 1
member entity reference: TCF7 isoform 6
member entity reference: Lymphoid enhancer-binding factor 1
member entity reference: TCF7L1 isoform 2
member entity reference: Transcription factor 7-like 1-A
member entity reference: Q9QXN1
member entity reference: F6WCX0

uniprot A0A2I3T8F7 1090
type: UnificationXref
id: A0A2I3T8F7
db: uniprot

Cadherin-10
type: ProteinReference
xref: uniprot Q9Y6N8 1007
xref: PTHR24027:SF290
organism: Homo sapiens

uniprot F6RPG1 90
type: UnificationXref
id: F6RPG1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24026:SF38
xref: uniprot F7GBV2 765
organism: Macaca mulatta

uniprot F7HRY3 1385
type: UnificationXref
id: F7HRY3
db: uniprot

PCDH9 isoform 4
type: ProteinReference
xref: uniprot H2R0P7 799
xref: PTHR24028:SF248
organism: Pan troglodytes

uniprot Q8TG12 1780
type: UnificationXref
id: Q8TG12
db: uniprot

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 1599
xref: PTHR19850:SF25
organism: Ixodes scapularis

Casein kinase I isoform gamma-3
type: ProteinReference
xref: PTHR11909:SF151
xref: uniprot Q9Y6M4 1875
organism: Homo sapiens

uniprot Q7TNL5 591
type: UnificationXref
id: Q7TNL5
db: uniprot

uniprot F7H4T8 1054
type: UnificationXref
id: F7H4T8
db: uniprot

uniprot P94593 370
type: UnificationXref
id: P94593
db: uniprot

uniprot O55134 804
type: UnificationXref
id: O55134
db: uniprot

uniprot Q9PWB0 1293
type: UnificationXref
id: Q9PWB0
db: uniprot

Casein kinase I homolog 3
type: ProteinReference
xref: uniprot O74135 1812
xref: PTHR11909:SF155
organism: 284812

Complex (TCF/Smad4)
type: Complex
component stoichiometry: TCF s57 sa232 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smad4 s58 sa233 STOICHIOMETRY ID COMPLEX
component: Smad4
component: TCF
feature: COMPLEX BINDING FEATURE s174 csa37 2251
feature: COMPLEX BINDING FEATURE s174 csa37 2249
cellular location: nucleus

uniprot E2R9M9 78
type: UnificationXref
id: E2R9M9
db: uniprot

SMARCE1 isoform 1
type: ProteinReference
xref: uniprot A0A2I3RU20 250
xref: PTHR46232:SF2
organism: Pan troglodytes

ncbitaxon 6238 30
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot Q8BWG8 1589
type: UnificationXref
id: Q8BWG8
db: uniprot

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 435

uniprot H9G268 334
type: UnificationXref
id: H9G268
db: uniprot

Dishevelled s143 sa128 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dishevelled
stoichiometric coefficient: 1.0

uniprot P05130 1675
type: UnificationXref
id: P05130
db: uniprot

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot A0A2R8QIW0 2046
organism: Danio rerio

TRANSPORT_LEFT__Wnt-RIGHT__Wnt-_r107
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r107 2486
participant stoichiometry: PARTICIPANT STOICHIOMETRY r107 2487
left: Wnt
interaction type: TRANSPORT
right: Wnt

uniprot F6S0B5 720
type: UnificationXref
id: F6S0B5
db: uniprot

PTHR22611:SF1
type: RelationshipXref
id: PTHR22611:SF1
db: PANTHER Family
relationship type: By Homology

PTHR22611:SF2
type: RelationshipXref
id: PTHR22611:SF2
db: PANTHER Family
relationship type: By Homology

ncbitaxon 284591 1771
type: UnificationXref
id: 284591
db: ncbitaxon

uniprot A0A3Q1M118 1517
type: UnificationXref
id: A0A3Q1M118
db: uniprot

PTHR22611:SF9
type: RelationshipXref
id: PTHR22611:SF9
db: PANTHER Family
relationship type: By Homology

uniprot P40589 1238
type: UnificationXref
id: P40589
db: uniprot

Adenomatous Polyposis Coli
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa21 2306
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3TLD4 1709
type: UnificationXref
id: A0A2I3TLD4
db: uniprot

GBeta
type: ProteinReference
xref: P01457
standard name: G protein, beta subunit
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.G_Beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: P26308
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: AGAP001506-PA
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: AGAP005912-PA
member entity reference: Guanine nucleotide binding protein, beta subunit
member entity reference: F7CXD0
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: G protein subunit beta 1
member entity reference: F6PVT7
member entity reference: AGAP005913-PA
member entity reference: Gnb2 protein
member entity reference: P29387
member entity reference: G protein subunit beta 2
member entity reference: AGAP005911-PA
member entity reference: THO complex subunit, putative
member entity reference: Q803H5
member entity reference: F6Y3N2
member entity reference: G protein subunit beta 3
member entity reference: A5PKD6
member entity reference: G-protein beta subunit

uniprot A8WR64 1649
type: UnificationXref
id: A8WR64
db: uniprot

PTHR15273:SF4
type: RelationshipXref
id: PTHR15273:SF4
db: PANTHER Family
relationship type: By Homology

Axin 2
type: ProteinReference
xref: uniprot K7CHS6 159
xref: PTHR46102:SF1
organism: Pan troglodytes

uniprot F6WDU9 734
type: UnificationXref
id: F6WDU9
db: uniprot

Myosin heavy chain 7B
type: DnaReference
xref: PTHR45615:SF29
organism: Canis lupus familiaris

uniprot E1BJ11 675
type: UnificationXref
id: E1BJ11
db: uniprot

ATP-dependent DNA helicase DDM1
type: ProteinReference
xref: uniprot Q9XFH4 450
xref: PTHR10799:SF923
organism: Arabidopsis thaliana

uniprot P63328 1340
type: UnificationXref
id: P63328
db: uniprot

PTHR10257:SF80
type: RelationshipXref
id: PTHR10257:SF80
db: PANTHER Family
relationship type: By Homology

Casein kinase II subunit alpha'
type: ProteinReference
xref: uniprot P19454 1747
xref: PTHR24054:SF27
organism: Saccharomyces cerevisiae

SWI/SNF
type: ProteinReference
xref: P01435
standard name: Switched/Sucrose Non Fermentation
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Switched/Sucrose Non Fermentation Synonym: Switched/Sucrose Non Fermentation Accession: P01435
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.SWI/SNF
member entity reference: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
member entity reference: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
member entity reference: AGAP005336-PA
member entity reference: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
member entity reference: Probable ATP-dependent DNA helicase CHR12
member entity reference: F1NCC9
member entity reference: SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily c, member 2
member entity reference: Q6DIC0
member entity reference: Helicase swr1
member entity reference: H2QVN0
member entity reference: Chromatin-remodeling ATPase INO80
member entity reference: Brahma associated protein 111kD
member entity reference: ISWI chromatin-remodeling complex ATPase CHR17
member entity reference: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
member entity reference: Q9CXF7
member entity reference: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
member entity reference: Lymphocyte-specific helicase
member entity reference: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (Predicted)
member entity reference: Uncharacterized protein
member entity reference: Probable chromatin-remodeling complex ATPase chain
member entity reference: A0A1D5QQU3
member entity reference: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
member entity reference: SWI/SNF and RSC complexes subunit ssr3
member entity reference: Probable global transcription activator SNF2L2
member entity reference: A5PKF6
member entity reference: O14470
member entity reference: ISWI chromatin-remodeling complex ATPase CHR11
member entity reference: Helicase SWR1
member entity reference: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
member entity reference: SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
member entity reference: P22082
member entity reference: Lymphoid-specific helicase
member entity reference: Q9NZC9
member entity reference: SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 1
member entity reference: Transcription activator BRG1
member entity reference: Chromatin-remodeling complex ATPase chain Iswi
member entity reference: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform a
member entity reference: SMARCA5 isoform 1
member entity reference: Chromatin structure-remodeling complex protein RSC8
member entity reference: F1PKX5
member entity reference: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
member entity reference: Chromatin remodeling protein
member entity reference: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
member entity reference: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
member entity reference: O54941
member entity reference: Q6DFM1
member entity reference: AT-rich interaction domain 1A
member entity reference: SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily e, member 1
member entity reference: G5EF53
member entity reference: H2Q2A9
member entity reference: ARID1A isoform 3
member entity reference: Helicase like transcription factor
member entity reference: SMARCC1 isoform 2
member entity reference: SMARCC2 isoform 2
member entity reference: A2BH40
member entity reference: Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1
member entity reference: A5PKK5
member entity reference: Helicase (SNF2 family)
member entity reference: E1C2F7
member entity reference: Q550R6
member entity reference: Helicase-like transcription factor
member entity reference: SWI/SNF complex subunit SMARCC1
member entity reference: SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 2

PTHR10257:SF89
type: RelationshipXref
id: PTHR10257:SF89
db: PANTHER Family
relationship type: By Homology

uniprot P51136 1023
type: UnificationXref
id: P51136
db: uniprot

SWI/SNF
type: Protein
entity reference: SWI/SNF
feature: COMPLEX PARTICIPANT BINDING FEATURE s104 sa71 2166
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P40233 1820
type: UnificationXref
id: P40233
db: uniprot

uniprot Q9P2E7 948
type: UnificationXref
id: Q9P2E7
db: uniprot

PTHR10336:SF149
type: RelationshipXref
id: PTHR10336:SF149
db: PANTHER Family
relationship type: By Homology

Beta Catenin s193 sa108 rs5
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

uniprot F1Q6Z7 545
type: UnificationXref
id: F1Q6Z7
db: uniprot

PTHR10257:SF92
type: RelationshipXref
id: PTHR10257:SF92
db: PANTHER Family
relationship type: By Homology

SNF chromatin remodeling Complex component
type: ProteinReference
xref: uniprot Q21831 379
xref: PTHR10019:SF5
organism: Caenorhabditis elegans

uniprot F1PD90 713
type: UnificationXref
id: F1PD90
db: uniprot

uniprot O59702 2070
type: UnificationXref
id: O59702
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A0A1D5Q8S7 1295
xref: PTHR45673:SF2
organism: Macaca mulatta

Catenin beta-1
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot Q9WU82 197
organism: Rattus norvegicus

uniprot Q9NPG4 943
type: UnificationXref
id: Q9NPG4
db: uniprot

uniprot Q9NL46 1398
type: UnificationXref
id: Q9NL46
db: uniprot

Smad4
type: Protein
entity reference: Smad4
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa55 2270
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF132
xref: uniprot A0A1D8PSA6 2045
organism: Candida albicans

Casein kinase I isoform gamma-2
type: ProteinReference
xref: PTHR11909:SF157
xref: uniprot P78368 1831
organism: Homo sapiens

Xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
type: ProteinReference
xref: uniprot A0A0R4IEK0 1294
xref: PTHR19300:SF30
organism: Danio rerio

uniprot Q61062 1396
type: UnificationXref
id: Q61062
db: uniprot

uniprot H2QJM8 1569
type: UnificationXref
id: H2QJM8
db: uniprot

uniprot A0A3Q1M2B9 258
type: UnificationXref
id: A0A3Q1M2B9
db: uniprot

Smad4
type: Protein
entity reference: Smad4
feature: COMPLEX PARTICIPANT BINDING FEATURE s94 sa64 2258
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__Nemo_like_Kinase-RIGHT__Nemo_like_Kinase-_r108
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r108 2482
participant stoichiometry: PARTICIPANT STOICHIOMETRY r108 2483
left: Nemo-like Kinase
interaction type: TRANSPORT
right: Nemo-like Kinase

Transducin beta-like 1
type: ProteinReference
xref: PTHR22846:SF52
xref: uniprot B7TCI5 1493
organism: Bos taurus

uniprot A0A1D5QFE1 1128
type: UnificationXref
id: A0A1D5QFE1
db: uniprot

uniprot Q9Y5F6 982
type: UnificationXref
id: Q9Y5F6
db: uniprot

uniprot Q62762 1839
type: UnificationXref
id: Q62762
db: uniprot

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF207
xref: uniprot G5ECH0 2062
organism: Caenorhabditis elegans

uniprot H2R0P7 799
type: UnificationXref
id: H2R0P7
db: uniprot

uniprot A2BH40 265
type: UnificationXref
id: A2BH40
db: uniprot

uniprot A0A1D5NUC4 1029
type: UnificationXref
id: A0A1D5NUC4
db: uniprot

Axin
type: Protein
entity reference: Axin
feature: COMPLEX PARTICIPANT BINDING FEATURE s132 sa117 2212
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P09544 1222
type: UnificationXref
id: P09544
db: uniprot

Phospholipase C
type: ProteinReference
xref: P01443
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Phospholipase C
comment: ENTITY_REFERENCE_NOTES= Long Name: Phospholipase C Synonym: PLC,PLC Beta,Phospholipase C Beta Accession: P01443
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
member entity reference: F1PL90
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
member entity reference: Q00722
member entity reference: J9JHK9
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
member entity reference: Phosphoinositide phospholipase C
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
member entity reference: Phosphoinositide phospholipase C (Fragment)
member entity reference: F1PLB3
member entity reference: A0A2J8QDF6
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Secreted frizzled-related protein 5
type: ProteinReference
xref: PTHR11309:SF46
xref: uniprot Q9WU66 245
organism: Mus musculus

PTHR19865:SF9
type: RelationshipXref
id: PTHR19865:SF9
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot F7HSM1 558
organism: Macaca mulatta

Casein kinase I isoform gamma-2
type: ProteinReference
xref: PTHR11909:SF157
xref: uniprot H9EP27 1810
organism: Macaca mulatta

Protein Wnt
type: ProteinReference
xref: uniprot A4ZGP0 1137
xref: PTHR12027:SF82
organism: Xenopus tropicalis

uniprot Q9LSX4 1867
type: UnificationXref
id: Q9LSX4
db: uniprot

uniprot Q8VH37 2097
type: UnificationXref
id: Q8VH37
db: uniprot

uniprot P55287 831
type: UnificationXref
id: P55287
db: uniprot

uniprot A0A3Q1MSP9 1647
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

uniprot Q96JP9 929
type: UnificationXref
id: Q96JP9
db: uniprot

uniprot P21279 1454
type: UnificationXref
id: P21279
db: uniprot

Cadherin-13
type: ProteinReference
xref: PTHR24027:SF80
xref: uniprot Q9WTR5 969
organism: Mus musculus

uniprot Q5F226 869
type: UnificationXref
id: Q5F226
db: uniprot

uniprot O77438 117
type: UnificationXref
id: O77438
db: uniprot

PCDH18 isoform 2
type: ProteinReference
xref: uniprot H2R198 800
xref: PTHR24028:SF9
organism: Pan troglodytes

PTHR11267:SF106
type: RelationshipXref
id: PTHR11267:SF106
db: PANTHER Family
relationship type: By Homology

uniprot A0A0R4IEK0 1294
type: UnificationXref
id: A0A0R4IEK0
db: uniprot

Bcl9 s86 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Bcl9
stoichiometric coefficient: 1.0

ncbitaxon 9031 13
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot A0A3Q1M1A0 1134
type: UnificationXref
id: A0A3Q1M1A0
db: uniprot

uniprot Q24368 382
type: UnificationXref
id: Q24368
db: uniprot

Cadherin-19
type: ProteinReference
xref: uniprot Q9H159 937
xref: PTHR24027:SF323
organism: Homo sapiens

Protocadherin alpha-C1
type: ProteinReference
xref: uniprot Q9H158 936
xref: PTHR24028:SF153
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF6
xref: uniprot K7CXU1 563
organism: Pan troglodytes

uniprot Q9Z329 49
type: UnificationXref
id: Q9Z329
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q9WTQ0 1707
organism: Rattus norvegicus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 387

uniprot F1NCC9 291
type: UnificationXref
id: F1NCC9
db: uniprot

ncbitaxon 237561 1768
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot O88572 182
type: UnificationXref
id: O88572
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q0V1Y4 1347
xref: PTHR45942:SF1
organism: Phaeosphaeria nodorum

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 1766

ANKRD6 isoform 2
type: ProteinReference
xref: uniprot K7BXC2 1993
xref: PTHR24203:SF7
organism: Pan troglodytes

Chromodomain-helicase-DNA-binding protein 1-like
type: ProteinReference
xref: PTHR47157:SF1
xref: uniprot H9G268 334
organism: Macaca mulatta

Protocadherin beta 2
type: ProteinReference
xref: uniprot F1M7D0 698
xref: PTHR24028:SF281
organism: Rattus norvegicus

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
type: ProteinReference
xref: uniprot F6Q1Z2 298
xref: PTHR10799:SF879
organism: Macaca mulatta

uniprot H2R0H8 329
type: UnificationXref
id: H2R0H8
db: uniprot

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: uniprot D3Z9H7 1473
xref: PTHR12533:SF11
organism: Rattus norvegicus

uniprot G7N677 178
type: UnificationXref
id: G7N677
db: uniprot

uniprot W4ZAK5 597
type: UnificationXref
id: W4ZAK5
db: uniprot

FRAT s154 sa139 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FRAT s154 sa139
stoichiometric coefficient: 1.0

uniprot P32121 1583
type: UnificationXref
id: P32121
db: uniprot

uniprot Q9CXF7 432
type: UnificationXref
id: Q9CXF7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot A0A1D5QLW3 1470
organism: Macaca mulatta

uniprot A0A2I3RU20 250
type: UnificationXref
id: A0A2I3RU20
db: uniprot

uniprot P63318 1690
type: UnificationXref
id: P63318
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: uniprot Q05513 1697
xref: PTHR24356:SF170
organism: Homo sapiens

uniprot Q6F2E8 1887
type: UnificationXref
id: Q6F2E8
db: uniprot

STATE_TRANSITION_LEFT__Dishevelled-RIGHT__Dishevelled-_re64
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 2505
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 2504
left: Dishevelled
interaction type: STATE_TRANSITION
right: Dishevelled

uniprot F2Z3R8 718
type: UnificationXref
id: F2Z3R8
db: uniprot

PTHR10257:SF19
type: RelationshipXref
id: PTHR10257:SF19
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot Q22944 380
xref: PTHR12176:SF64
organism: Caenorhabditis elegans

uniprot Q15173 581
type: UnificationXref
id: Q15173
db: uniprot

Peroxisome proliferator activated receptor delta, isoform CRA_b
type: DnaReference
xref: PTHR24082:SF15
organism: Rattus norvegicus

PYGO2 isoform 3
type: ProteinReference
xref: uniprot H2Q058 1912
xref: PTHR23194:SF7
organism: Pan troglodytes

uniprot F6VCI6 1730
type: UnificationXref
id: F6VCI6
db: uniprot

uniprot G3N018 2022
type: UnificationXref
id: G3N018
db: uniprot

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
type: ProteinReference
xref: PTHR13844:SF1
xref: uniprot J9P148 337
organism: Canis lupus familiaris

STATE_TRANSITION
type: InteractionVocabulary

uniprot H2QNL0 206
type: UnificationXref
id: H2QNL0
db: uniprot

TRANSPORT
type: InteractionVocabulary

Transcription factor 7-like 2
type: DnaReference
xref: PTHR10373:SF32
organism: Homo sapiens

Transcription factor 7-like 1
type: DnaReference
xref: PTHR10373:SF25
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
type: ProteinReference
xref: PTHR10257:SF80
xref: uniprot Q16537 582
organism: Homo sapiens

uniprot A5WVU0 1492
type: UnificationXref
id: A5WVU0
db: uniprot

Cadherin-related tumor suppressor
type: ProteinReference
xref: PTHR24026:SF76
xref: uniprot P33450 822
organism: Drosophila melanogaster

serine33 Beta Catenin s76 sa40 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY serine33
feature location: serine33 Beta Catenin s76 sa40 rs3 serine33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=serine33
comment: MODIFICATION_RESIDUE_ANGLE=5.531231296344393

Serine35 Beta Catenin s82 sa52 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s82 sa52 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

uniprot Q9I8V2 1557
type: UnificationXref
id: Q9I8V2
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot B0BLZ8 1304
organism: Xenopus tropicalis

uniprot F7BBY2 746
type: UnificationXref
id: F7BBY2
db: uniprot

Protocadherin 18
type: ProteinReference
xref: uniprot Q8VHR0 902
xref: PTHR24028:SF9
organism: Mus musculus

uniprot F6U298 1050
type: UnificationXref
id: F6U298
db: uniprot

Cadherin-related family member 2
type: ProteinReference
xref: PTHR24026:SF75
xref: uniprot Q9BYE9 933
organism: Homo sapiens

STATE_TRANSITION_LEFT__Wnt-RIGHT__Wnt-_re63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 2512
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 2513
left: Wnt
interaction type: STATE_TRANSITION
right: Wnt

uniprot Q19319 848
type: UnificationXref
id: Q19319
db: uniprot

Chromatin-remodeling ATPase INO80
type: ProteinReference
xref: uniprot Q6ZPV2 403
xref: PTHR45685:SF2
organism: Mus musculus

uniprot W4Y0D3 198
type: UnificationXref
id: W4Y0D3
db: uniprot

Complex (Adenomatous Polyposis Coli/Axin/ Diversin/Beta-Catenin/ PP2A)
type: Complex
component stoichiometry: PP2A s70 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: Axin s67 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: Adenomatous Polyposis Coli s66 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: Diversin s68 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Catenin s69 sa29 STOICHIOMETRY ID COMPLEX
component: Beta-Catenin
component: PP2A
component: Adenomatous Polyposis Coli
component: Diversin
component: Axin
feature: COMPLEX BINDING FEATURE s129 a292 2279
feature: COMPLEX BINDING FEATURE s129 a292 2275
feature: COMPLEX BINDING FEATURE s129 a292 2273
feature: COMPLEX BINDING FEATURE s129 a292 2281
feature: COMPLEX BINDING FEATURE s129 a292 2277
cellular location: plasma membrane

Wnt Target Genes
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

uniprot Q9VQE3 1873
type: UnificationXref
id: Q9VQE3
db: uniprot

uniprot Q920M9 222
type: UnificationXref
id: Q920M9
db: uniprot

Kringle containing transmembrane protein 1
type: ProteinReference
xref: uniprot F1MRR1 1897
organism: Bos taurus

uniprot A2VDQ6 659
type: UnificationXref
id: A2VDQ6
db: uniprot

CDH19 isoform 2
type: ProteinReference
xref: uniprot A0A2I3SHA1 640
xref: PTHR24027:SF323
organism: Pan troglodytes

TCF s83 sa53 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11937:SF414
type: RelationshipXref
id: PTHR11937:SF414
db: PANTHER Family
relationship type: By Homology

uniprot C3ZBE3 1720
type: UnificationXref
id: C3ZBE3
db: uniprot

actin, muscle-like
type: DnaReference
xref: PTHR11937:SF46
organism: 7719

uniprot D3ZCM7 462
type: UnificationXref
id: D3ZCM7
db: uniprot

uniprot O88277 808
type: UnificationXref
id: O88277
db: uniprot

uniprot P55290 834
type: UnificationXref
id: P55290
db: uniprot

uniprot O55233 1291
type: UnificationXref
id: O55233
db: uniprot

uniprot Q9HCS4 514
type: UnificationXref
id: Q9HCS4
db: uniprot

SWI/SNF complex component SNF12 homolog
type: ProteinReference
xref: uniprot Q9FMT4 433
xref: PTHR13844:SF7
organism: Arabidopsis thaliana

uniprot O75309 807
type: UnificationXref
id: O75309
db: uniprot

TCF
type: Protein
entity reference: TCF
feature: TCF s197 a450 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F6YVV6 1316
type: UnificationXref
id: F6YVV6
db: uniprot

Frodo s25 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Frodo
stoichiometric coefficient: 1.0

Myosin-7B
type: DnaReference
xref: PTHR45615:SF29
organism: Mus musculus

uniprot A0A3Q1LWF7 256
type: UnificationXref
id: A0A3Q1LWF7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 1967
xref: PTHR13809:SF25
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r99 2431
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Beta-Catenin/ Axin/PP2A)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r99 2432
type: Stoichiometry
physical entity: Complex Adenomatous Polyposis Coli Axin PP2A s164 a378
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r99 2433
type: Stoichiometry
physical entity: Beta-Catenin
stoichiometric coefficient: 1.0

uniprot F6SLU9 1175
type: UnificationXref
id: F6SLU9
db: uniprot

uniprot F6WCX0 507
type: UnificationXref
id: F6WCX0
db: uniprot

uniprot Q8K4C8 136
type: UnificationXref
id: Q8K4C8
db: uniprot

TRANSCRIPTION_LEFT__NFAT_Target_Genes-RIGHT__NAFT_Target_Genes-_re68
type: TemplateReaction
product: NAFT Target Genes
xref: TRANSCRIPTION
participant: NFAT Target Genes
participant: NAFT Target Genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY r66 2448
type: Stoichiometry
physical entity: Complex (Beta-Catenin/TCF/ Smad4/Bcl9/ Pygo/SWI/ SNF)
stoichiometric coefficient: 1.0

Cadherin
type: Protein
entity reference: Cadherin
feature: COMPLEX PARTICIPANT BINDING FEATURE s304 sa124 2342
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r66 2446
type: Stoichiometry
physical entity: SWI/SNF
stoichiometric coefficient: 1.0

uniprot D4A3K6 1155
type: UnificationXref
id: D4A3K6
db: uniprot

uniprot P28465 1234
type: UnificationXref
id: P28465
db: uniprot

PARTICIPANT STOICHIOMETRY r66 2447
type: Stoichiometry
physical entity: Complex (Bcl9/Beta-Catenin/ TCF/Smad4/ Pygo)
stoichiometric coefficient: 1.0

Calcineurin subunit B type 1
type: ProteinReference
xref: uniprot Q63810 1357
xref: PTHR45942:SF3
organism: Mus musculus

Calcineurin subunit B type 2
type: ProteinReference
xref: PTHR45942:SF2
xref: uniprot Q63811 1358
organism: Mus musculus

Mothers against decapentaplegic homolog 4
type: ProteinReference
xref: uniprot O70437 1544
xref: PTHR13703:SF45
organism: Rattus norvegicus

ncbitaxon 237631 2042
type: UnificationXref
id: 237631
db: ncbitaxon

uniprot Q9Y5F0 978
type: UnificationXref
id: Q9Y5F0
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot A4FV68 529
organism: Bos taurus

uniprot Q3HRP5 1352
type: UnificationXref
id: Q3HRP5
db: uniprot

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
type: ProteinReference
xref: PTHR45766:SF3
xref: uniprot Q8BJL0 414
organism: Mus musculus

uniprot P62871 1627
type: UnificationXref
id: P62871
db: uniprot

TLE family member 1, transcriptional corepressor
type: ProteinReference
xref: uniprot D3ZCM7 462
xref: PTHR10814:SF29
organism: Rattus norvegicus

TGFbetaactivated Kinase-1
type: ProteinReference
xref: P01442
standard name: Transforming growth factor beta activated kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.TGF_beta_activated Kinase-1
comment: ENTITY_REFERENCE_NOTES= Long Name: Transforming growth factor beta activated kinase 1 Synonym: MAPKKK 7,Mitogen-Activated Protein Kinase Kinase Kinase 7,TAK1 Accession: P01442
member entity reference: Receptor protein serine/threonine kinase
member entity reference: Serine/threonine-protein kinase receptor
member entity reference: F7CCD5
member entity reference: Bone morphogenetic protein receptor type-1A
member entity reference: Activin receptor type-1B
member entity reference: Mitogen-activated protein kinase kinase kinase 7
member entity reference: Activin receptor type-1C
member entity reference: Q64729
member entity reference: H2Q272
member entity reference: MAP3K7 C-terminal-like protein
member entity reference: Uncharacterized protein
member entity reference: O46680
member entity reference: Q09488
member entity reference: Bone morphogenetic protein receptor type-1B
member entity reference: F7HNS7
member entity reference: F6S9J1
member entity reference: F6Q8L1
member entity reference: F7ESG8
member entity reference: F1MMW7
member entity reference: TGF-beta receptor type-1
member entity reference: Q1RLX1
member entity reference: Q78EA7
member entity reference: F1NTD3

P01428
type: UnificationXref
id: P01428
db: PANTHER Pathway Component

P01427
type: UnificationXref
id: P01427
db: PANTHER Pathway Component

WD40 repeat-containing protein HOS15
type: ProteinReference
xref: uniprot Q9FN19 1509
xref: PTHR22846:SF2
organism: Arabidopsis thaliana

P01429
type: UnificationXref
id: P01429
db: PANTHER Pathway Component

P01426
type: UnificationXref
id: P01426
db: PANTHER Pathway Component

uniprot Q8IUQ4 218
type: UnificationXref
id: Q8IUQ4
db: uniprot

uniprot Q8BIZ0 890
type: UnificationXref
id: Q8BIZ0
db: uniprot

E3 ubiquitin-protein ligase SINAT3
type: ProteinReference
xref: PTHR10315:SF80
xref: uniprot Q84JL3 216
organism: Arabidopsis thaliana

Axin
type: Protein
entity reference: Axin
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

P01431
type: UnificationXref
id: P01431
db: PANTHER Pathway Component

P01432
type: UnificationXref
id: P01432
db: PANTHER Pathway Component

P01433
type: UnificationXref
id: P01433
db: PANTHER Pathway Component

Protein kinase C-like 1B
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot P34885 1688
organism: Caenorhabditis elegans

Casein kinase II subunit alpha
type: ProteinReference
xref: PTHR24054:SF34
xref: uniprot H9ENR6 1733
organism: Macaca mulatta

uniprot Q06985 211
type: UnificationXref
id: Q06985
db: uniprot

PTHR11937:SF446
type: RelationshipXref
id: PTHR11937:SF446
db: PANTHER Family
relationship type: By Homology

uniprot G5EF53 322
type: UnificationXref
id: G5EF53
db: uniprot

PTHR11937:SF445
type: RelationshipXref
id: PTHR11937:SF445
db: PANTHER Family
relationship type: By Homology

uniprot Q9UBI6 1988
type: UnificationXref
id: Q9UBI6
db: uniprot

uniprot Q9DEB8 1273
type: UnificationXref
id: Q9DEB8
db: uniprot

Frizzled-1
type: ProteinReference
xref: uniprot O70421 115
xref: PTHR11309:SF81
organism: Mus musculus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF80
xref: uniprot A0A2I3TDL0 526
organism: Pan troglodytes

Serine35 Beta Catenin s128 sa114 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s128 sa114 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

uniprot F6SD46 1098
type: UnificationXref
id: F6SD46
db: uniprot

Adenomatous Polyposis Coli s134 sa119 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adenomatous Polyposis Coli s134 sa119
stoichiometric coefficient: 1.0

Protocadherin 8
type: ProteinReference
xref: uniprot F1REQ8 716
xref: PTHR24028:SF244
organism: Danio rerio

uniprot B7Q3T6 1599
type: UnificationXref
id: B7Q3T6
db: uniprot

uniprot E2R2S8 1602
type: UnificationXref
id: E2R2S8
db: uniprot

uniprot Q5DRD3 860
type: UnificationXref
id: Q5DRD3
db: uniprot

Complex (Dickkopf/Kremen)
type: Complex
component stoichiometry: Dickkopf s6 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Kremen s11 sa4 STOICHIOMETRY ID COMPLEX
component: Dickkopf
component: Kremen
feature: COMPLEX BINDING FEATURE s21 a21 2215
feature: COMPLEX BINDING FEATURE s21 a21 2217
cellular location: plasma membrane

uniprot P38409 1461
type: UnificationXref
id: P38409
db: uniprot

uniprot P21278 1453
type: UnificationXref
id: P21278
db: uniprot

Actin, alpha cardiac muscle 2
type: DnaReference
xref: PTHR11937:SF416
organism: Xenopus tropicalis

uniprot Q91ZI0 927
type: UnificationXref
id: Q91ZI0
db: uniprot

Transmembrane receptor LIN-17
type: ProteinReference
xref: PTHR11309:SF137
xref: uniprot G5EDV1 104
organism: Caenorhabditis elegans

Protein Wnt-1
type: ProteinReference
xref: uniprot P34888 1236
xref: PTHR12027:SF101
organism: Caenorhabditis elegans

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF77
xref: uniprot P34889 1237
organism: Caenorhabditis elegans

uniprot K7AE17 1956
type: UnificationXref
id: K7AE17
db: uniprot

Putative helicase
type: ProteinReference
xref: uniprot Q9RKT0 440
xref: PTHR10799:SF987
organism: 100226

uniprot H9EPM1 1016
type: UnificationXref
id: H9EPM1
db: uniprot

uniprot Q91YI4 1590
type: UnificationXref
id: Q91YI4
db: uniprot

uniprot P50151 1962
type: UnificationXref
id: P50151
db: uniprot

uniprot A0A1D5P395 154
type: UnificationXref
id: A0A1D5P395
db: uniprot

PTHR11937:SF416
type: RelationshipXref
id: PTHR11937:SF416
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GFC4 318
xref: PTHR45626:SF39
organism: Macaca mulatta

PTHR11309:SF7
type: RelationshipXref
id: PTHR11309:SF7
db: PANTHER Family
relationship type: By Homology

uniprot Q9Y5I2 1004
type: UnificationXref
id: Q9Y5I2
db: uniprot

GH08712p
type: ProteinReference
xref: uniprot Q24090 381
xref: PTHR10019:SF5
organism: Drosophila melanogaster

Casein kinase II, alpha chain, putative, expressed
type: ProteinReference
xref: PTHR24054:SF43
xref: uniprot Q8W5G9 1782
organism: Oryza sativa

P01472
type: UnificationXref
id: P01472
db: PANTHER Pathway Component

P01471
type: UnificationXref
id: P01471
db: PANTHER Pathway Component

P01470
type: UnificationXref
id: P01470
db: PANTHER Pathway Component

Serine/threonine-protein phosphatase 2B catalytic subunit
type: ProteinReference
xref: uniprot Q7YSW8 1366
xref: PTHR45673:SF1
organism: Dictyostelium discoideum

uniprot Q6PCN7 399
type: UnificationXref
id: Q6PCN7
db: uniprot

uniprot F1PCS0 174
type: UnificationXref
id: F1PCS0
db: uniprot

uniprot Q9QXE7 1510
type: UnificationXref
id: Q9QXE7
db: uniprot

uniprot H2RAM0 1207
type: UnificationXref
id: H2RAM0
db: uniprot

uniprot Q6DIS7 1555
type: UnificationXref
id: Q6DIS7
db: uniprot

uniprot F6XMN6 1660
type: UnificationXref
id: F6XMN6
db: uniprot

ncbitaxon 6239 48
type: UnificationXref
id: 6239
db: ncbitaxon

P01469
type: UnificationXref
id: P01469
db: PANTHER Pathway Component

SMARCD2 isoform 2
type: ProteinReference
xref: PTHR13844:SF2
xref: uniprot H2QDN6 324
organism: Pan troglodytes

Diversin s125 sa93 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Diversin
stoichiometric coefficient: 1.0

P01464
type: UnificationXref
id: P01464
db: PANTHER Pathway Component

P01463
type: UnificationXref
id: P01463
db: PANTHER Pathway Component

P01466
type: UnificationXref
id: P01466
db: PANTHER Pathway Component

Catenin beta-1
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot B6V8E6 185
organism: Canis lupus familiaris

P01465
type: UnificationXref
id: P01465
db: PANTHER Pathway Component

P01460
type: UnificationXref
id: P01460
db: PANTHER Pathway Component

uniprot E2QVP7 77
type: UnificationXref
id: E2QVP7
db: uniprot

P01461
type: UnificationXref
id: P01461
db: PANTHER Pathway Component

uniprot E1BCK4 672
type: UnificationXref
id: E1BCK4
db: uniprot

uniprot A1Z7L8 1034
type: UnificationXref
id: A1Z7L8
db: uniprot

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot E1C3Q9 201
organism: 9031

uniprot Q08209 1345
type: UnificationXref
id: Q08209
db: uniprot

P01456
type: UnificationXref
id: P01456
db: PANTHER Pathway Component

P01457
type: UnificationXref
id: P01457
db: PANTHER Pathway Component

P01458
type: UnificationXref
id: P01458
db: PANTHER Pathway Component

P01459
type: UnificationXref
id: P01459
db: PANTHER Pathway Component

P01451
type: UnificationXref
id: P01451
db: PANTHER Pathway Component

P01450
type: UnificationXref
id: P01450
db: PANTHER Pathway Component

uniprot F2Z3R5 717
type: UnificationXref
id: F2Z3R5
db: uniprot

Homeotic protein ultrabithorax
type: DnaReference
xref: PTHR45659:SF15
organism: Drosophila melanogaster

Cadherin-11 preproprotein
type: ProteinReference
xref: uniprot F7GFF0 766
xref: PTHR24027:SF85
organism: Macaca mulatta

P01455
type: UnificationXref
id: P01455
db: PANTHER Pathway Component

P01454
type: UnificationXref
id: P01454
db: PANTHER Pathway Component

PTHR19850:SF27
type: RelationshipXref
id: PTHR19850:SF27
db: PANTHER Family
relationship type: By Homology

P01453
type: UnificationXref
id: P01453
db: PANTHER Pathway Component

P01452
type: UnificationXref
id: P01452
db: PANTHER Pathway Component

PTHR19850:SF25
type: RelationshipXref
id: PTHR19850:SF25
db: PANTHER Family
relationship type: By Homology

uniprot A8WY01 2047
type: UnificationXref
id: A8WY01
db: uniprot

Ggamma s162 sa78 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Casein kinase I isoform gamma-3
type: ProteinReference
xref: PTHR11909:SF151
xref: uniprot Q62763 1840
organism: Rattus norvegicus

P01447
type: UnificationXref
id: P01447
db: PANTHER Pathway Component

DISSOCIATION
type: RelationshipTypeVocabulary

P01448
type: UnificationXref
id: P01448
db: PANTHER Pathway Component

P01445
type: UnificationXref
id: P01445
db: PANTHER Pathway Component

PTHR19850:SF29
type: RelationshipXref
id: PTHR19850:SF29
db: PANTHER Family
relationship type: By Homology

P01446
type: UnificationXref
id: P01446
db: PANTHER Pathway Component

PTHR19850:SF28
type: RelationshipXref
id: PTHR19850:SF28
db: PANTHER Family
relationship type: By Homology

P01449
type: UnificationXref
id: P01449
db: PANTHER Pathway Component

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
type: ProteinReference
xref: uniprot Q6STE5 402
xref: PTHR13844:SF5
organism: Homo sapiens

P01440
type: UnificationXref
id: P01440
db: PANTHER Pathway Component

P01442
type: UnificationXref
id: P01442
db: PANTHER Pathway Component

uniprot F6YMS3 1537
type: UnificationXref
id: F6YMS3
db: uniprot

P01441
type: UnificationXref
id: P01441
db: PANTHER Pathway Component

P01444
type: UnificationXref
id: P01444
db: PANTHER Pathway Component

P01443
type: UnificationXref
id: P01443
db: PANTHER Pathway Component

C-terminal binding protein 2
type: ProteinReference
xref: uniprot H2Q2Q9 608
xref: PTHR46029:SF3
organism: Pan troglodytes

Casein kinase I isoform gamma-1
type: ProteinReference
xref: PTHR11909:SF156
xref: uniprot Q62761 1838
organism: Rattus norvegicus

Casein kinase I isoform gamma-2
type: ProteinReference
xref: uniprot Q62762 1839
xref: PTHR11909:SF157
organism: Rattus norvegicus

uniprot P51141 1391
type: UnificationXref
id: P51141
db: uniprot

uniprot G5ECH0 2062
type: UnificationXref
id: G5ECH0
db: uniprot

uniprot Q5DRD8 863
type: UnificationXref
id: Q5DRD8
db: uniprot

uniprot E2QX25 1794
type: UnificationXref
id: E2QX25
db: uniprot

P01434
type: UnificationXref
id: P01434
db: PANTHER Pathway Component

P01435
type: UnificationXref
id: P01435
db: PANTHER Pathway Component

P01436
type: UnificationXref
id: P01436
db: PANTHER Pathway Component

P01437
type: UnificationXref
id: P01437
db: PANTHER Pathway Component

P01438
type: UnificationXref
id: P01438
db: PANTHER Pathway Component

P01439
type: UnificationXref
id: P01439
db: PANTHER Pathway Component

PTHR14604:SF4
type: RelationshipXref
id: PTHR14604:SF4
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF82
xref: uniprot D3ZCR1 1150
organism: Rattus norvegicus

uniprot P67870 1758
type: UnificationXref
id: P67870
db: uniprot

uniprot Q9UN70 957
type: UnificationXref
id: Q9UN70
db: uniprot

uniprot Q9DEG7 616
type: UnificationXref
id: Q9DEG7
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot F6Q932 1313
organism: Macaca mulatta

PTHR19850:SF30
type: RelationshipXref
id: PTHR19850:SF30
db: PANTHER Family
relationship type: By Homology

Myosin, heavy polypeptide 13, skeletal muscle
type: DnaReference
xref: PTHR45615:SF44
organism: Mus musculus

uniprot Q95NF3 1591
type: UnificationXref
id: Q95NF3
db: uniprot

uniprot E9PXQ7 689
type: UnificationXref
id: E9PXQ7
db: uniprot

PTHR19850:SF31
type: RelationshipXref
id: PTHR19850:SF31
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZBJ4 508
xref: PTHR10373:SF11
organism: Monodelphis domestica

uniprot P67962 1830
type: UnificationXref
id: P67962
db: uniprot

Frizzled-4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot Q9QZH0 146
organism: Rattus norvegicus

Beta Catenin s111 sa83 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Serine45 Beta Catenin s69 sa29 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s69 sa29 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot H2QDQ1 1669
organism: Pan troglodytes

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: COMPLEX PARTICIPANT BINDING FEATURE s128 sa114 2206
feature: Serine35 Beta Catenin s128 sa114 rs2
feature: Beta Catenin s128 sa114 rs5
feature: Serine45 Beta Catenin s128 sa114 rs1
feature: Threonine41 Beta Catenin s128 sa114 rs4
feature: serine33 Beta Catenin s128 sa114 rs3
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q96HF1 242
type: UnificationXref
id: Q96HF1
db: uniprot

Protocadherin-related 15
type: ProteinReference
xref: uniprot F1LXN4 695
xref: PTHR24028:SF11
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR46342:SF1
xref: uniprot E1BBP2 2012
organism: Bos taurus

uniprot A8X5S0 1563
type: UnificationXref
id: A8X5S0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 1974
xref: PTHR13809:SF5
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 1973
xref: PTHR13809:SF5
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 1972
xref: PTHR13809:SF5
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot P63216 1971
organism: Mus musculus

Beta Catenin s69 sa29 rs5
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.7491388944474044
comment: MODIFICATION_RESIDUE_NAME=

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot P63215 1970
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot P63214 1969
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: PTHR13809:SF25
xref: uniprot P63213 1968
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Calcineurin-RIGHT__Calcineurin-_r79
controller: Ca2 PLUS s294 a618

uniprot Q8K1P7 416
type: UnificationXref
id: Q8K1P7
db: uniprot

uniprot Q9WVB9 1399
type: UnificationXref
id: Q9WVB9
db: uniprot

uniprot Q8TAQ2 421
type: UnificationXref
id: Q8TAQ2
db: uniprot

STATE_TRANSITION_LEFT__Glycogen_Synthase_Kinase_3Beta-RIGHT__Glycogen_Synthase_Kinase_3Beta-_re69
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 2485
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 2484
left: Glycogen Synthase Kinase-3Beta
interaction type: STATE_TRANSITION
right: Glycogen Synthase Kinase-3Beta

Uncharacterized protein
type: ProteinReference
xref: PTHR10799:SF76
xref: uniprot F6Q910 299
organism: 9258

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF88
xref: uniprot H2R817 1206
organism: Pan troglodytes

Uncharacterized protein
type: DnaReference
xref: PTHR45615:SF6
organism: Macaca mulatta

uniprot F6WEY4 204
type: UnificationXref
id: F6WEY4
db: uniprot

PTHR13874:SF10
type: RelationshipXref
id: PTHR13874:SF10
db: PANTHER Family
relationship type: By Homology

uniprot F1M7E5 699
type: UnificationXref
id: F1M7E5
db: uniprot

uniprot B5DFG8 1906
type: UnificationXref
id: B5DFG8
db: uniprot

Actin, alpha cardiac muscle 1
type: DnaReference
xref: PTHR11937:SF176
organism: 9031

Protein Wnt-7a
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot O00755 1213
organism: Homo sapiens

Serine35 Beta Catenin s135 sa120 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s135 sa120 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

uniprot F7FBX6 2020
type: UnificationXref
id: F7FBX6
db: uniprot

uniprot H2Q2A9 323
type: UnificationXref
id: H2Q2A9
db: uniprot

Beta-Catenin
type: Protein
entity reference: Beta-Catenin
feature: Serine35 Beta Catenin s82 sa52 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa52 2244
feature: Threonine41 Beta Catenin s82 sa52 rs4
feature: Serine45 Beta Catenin s82 sa52 rs1
feature: Beta Catenin s82 sa52 rs5
feature: serine33 Beta Catenin s82 sa52 rs3
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q66JF0 1467
type: UnificationXref
id: Q66JF0
db: uniprot

Protein B-Myc
type: DnaReference
xref: PTHR45851:SF6
organism: Mus musculus

uniprot Q8C4U3 240
type: UnificationXref
id: Q8C4U3
db: uniprot

Calcineurin subunit B type 1
type: ProteinReference
xref: uniprot P48451 1329
xref: PTHR45942:SF1
organism: Drosophila melanogaster

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P48453 1331
xref: PTHR45673:SF7
organism: Mus musculus

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot P48452 1330
organism: Bos taurus

uniprot A0A2J8LQ46 1132
type: UnificationXref
id: A0A2J8LQ46
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF77
xref: uniprot Q9U6V0 1281
organism: 7719

PTHR24027:SF96
type: RelationshipXref
id: PTHR24027:SF96
db: PANTHER Family
relationship type: By Homology

PTHR24027:SF91
type: RelationshipXref
id: PTHR24027:SF91
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PMG0 624
xref: PTHR24028:SF248
organism: 9031

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot P48455 1333
xref: PTHR45673:SF2
organism: Mus musculus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q7PKK6 1365
xref: PTHR45673:SF1
organism: Anopheles gambiae

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR45673:SF2
xref: uniprot P48454 1332
organism: Homo sapiens

Serine/threonine-protein phosphatase 2B catalytic subunit
type: ProteinReference
xref: uniprot P48457 1335
xref: PTHR45673:SF1
organism: Emericella nidulans

Serine/threonine-protein phosphatase 2B catalytic subunit 1
type: ProteinReference
xref: uniprot P48456 1334
xref: PTHR45673:SF1
organism: Drosophila melanogaster

uniprot Q05655 1698
type: UnificationXref
id: Q05655
db: uniprot

uniprot A9UJN4 531
type: UnificationXref
id: A9UJN4
db: uniprot

PTHR24027:SF89
type: RelationshipXref
id: PTHR24027:SF89
db: PANTHER Family
relationship type: By Homology

Adenomatous Polyposis Coli
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s187 sa103 2124
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot H2QLS0 1407
type: UnificationXref
id: H2QLS0
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot P48463 566
organism: 9031

Cerberus 1, DAN family BMP antagonist
type: ProteinReference
xref: uniprot H2QX07 1290
xref: PTHR15273:SF4
organism: Pan troglodytes

C-terminal binding protein 1
type: ProteinReference
xref: uniprot A0A2I3SKD1 599
xref: PTHR46029:SF2
organism: Pan troglodytes

Complex (Bcl9/Pygo/ Beta-Catenin/SWI/ SNF/CBP/ TCF/Smad4)
type: Complex
component stoichiometry: Beta Catenin s100 sa70 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smad4 s109 sa74 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCF s106 sa73 STOICHIOMETRY ID COMPLEX
component stoichiometry: SWI SNF s104 sa71 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pygo s99 sa69 STOICHIOMETRY ID COMPLEX
component stoichiometry: Bcl9 s98 sa68 STOICHIOMETRY ID COMPLEX
component stoichiometry: CBP s105 sa72 STOICHIOMETRY ID COMPLEX
component: Bcl9 s98 sa68
component: Smad4
component: TCF
component: Pygo
component: Beta-Catenin
component: CBP
component: SWI/SNF
feature: COMPLEX BINDING FEATURE s194 a448 2161
feature: COMPLEX BINDING FEATURE s194 a448 2167
feature: COMPLEX BINDING FEATURE s194 a448 2163
feature: COMPLEX BINDING FEATURE s194 a448 2171
feature: COMPLEX BINDING FEATURE s194 a448 2165
feature: ACTIVE 50
feature: COMPLEX BINDING FEATURE s194 a448 2159
feature: COMPLEX BINDING FEATURE s194 a448 2169
cellular location: nucleus

PTHR24027:SF84
type: RelationshipXref
id: PTHR24027:SF84
db: PANTHER Family
relationship type: By Homology

PTHR24027:SF85
type: RelationshipXref
id: PTHR24027:SF85
db: PANTHER Family
relationship type: By Homology

PTHR24027:SF80
type: RelationshipXref
id: PTHR24027:SF80
db: PANTHER Family
relationship type: By Homology

PTHR24027:SF81
type: RelationshipXref
id: PTHR24027:SF81
db: PANTHER Family
relationship type: By Homology

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
type: ProteinReference
xref: PTHR13844:SF2
xref: uniprot Q92925 426
organism: Homo sapiens

PTHR24027:SF79
type: RelationshipXref
id: PTHR24027:SF79
db: PANTHER Family
relationship type: By Homology

SWI/SNF complex subunit SMARCC1
type: ProteinReference
xref: PTHR12802:SF9
xref: uniprot Q92922 425
organism: Homo sapiens

Serine35 Beta Catenin s270 a146 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine35
feature location: Serine35 Beta Catenin s270 a146 rs2 Serine35
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine35
comment: MODIFICATION_RESIDUE_ANGLE=0.8072147790473774

Dapper
type: Protein
entity reference: Dapper
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r91 2476
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Axin/ Diversin/Casein Kinase 1/ Glycogen Synthase Kinase-3Beta/PP2A)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r91 2475
type: Stoichiometry
physical entity: Complex (betaTrCP/Beta-Catenin)
stoichiometric coefficient: 1.0

uniprot A0A3Q2U0V6 601
type: UnificationXref
id: A0A3Q2U0V6
db: uniprot

PARTICIPANT STOICHIOMETRY r91 2474
type: Stoichiometry
physical entity: Complex (Adenomatous Polyposis Coli/Axin/ PP2A/Diversin/ Casein Kinase 1/Beta-Catenin/ betaTrCP/Glycogen Synthase Kinase-3Beta)
stoichiometric coefficient: 1.0

uniprot F7GFC4 318
type: UnificationXref
id: F7GFC4
db: uniprot

Catenin alpha 1
type: ProteinReference
xref: PTHR18914:SF24
xref: uniprot F7DHT4 2019
organism: Xenopus tropicalis

uniprot Q9BRQ0 1914
type: UnificationXref
id: Q9BRQ0
db: uniprot

Histone deacetylase
type: Protein
entity reference: Histone deacetylase
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa48 2220
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F1PCF1 1898
type: UnificationXref
id: F1PCF1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 1614
xref: PTHR19850:SF28
organism: Monodelphis domestica

Casein kinase I isoform alpha isoform 1
type: ProteinReference
xref: PTHR11909:SF84
xref: uniprot H9ENA3 1809
organism: Macaca mulatta

uniprot P67871 1759
type: UnificationXref
id: P67871
db: uniprot

uniprot H2R2U1 191
type: UnificationXref
id: H2R2U1
db: uniprot

uniprot Q7PT75 880
type: UnificationXref
id: Q7PT75
db: uniprot

uniprot F6SH04 91
type: UnificationXref
id: F6SH04
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot H2QEJ6 1542
xref: PTHR13703:SF45
organism: Pan troglodytes

uniprot H2QBL4 789
type: UnificationXref
id: H2QBL4
db: uniprot

PP2A s65 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A
stoichiometric coefficient: 1.0

Protocadherin-20
type: ProteinReference
xref: uniprot Q8BIZ0 890
xref: PTHR24028:SF260
organism: Mus musculus

uniprot F6SGW3 230
type: UnificationXref
id: F6SGW3
db: uniprot

uniprot A0A2I3TI13 1131
type: UnificationXref
id: A0A2I3TI13
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F6SLU9 1175
xref: PTHR12027:SF91
organism: Macaca mulatta

uniprot P17870 1577
type: UnificationXref
id: P17870
db: uniprot

uniprot Q9Y5E7 975
type: UnificationXref
id: Q9Y5E7
db: uniprot

Low-density lipoprotein receptor-related protein 6
type: ProteinReference
xref: uniprot O75581 181
xref: PTHR24270:SF12
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR10814:SF31
xref: uniprot A0A1D5RAC8 455
organism: Macaca mulatta

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 217

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF217
xref: uniprot F1N2V3 1443
organism: Bos taurus

Dishevelled segment polarity protein 3a
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot B8JMI2 1376
organism: Danio rerio

uniprot M0R9D3 1211
type: UnificationXref
id: M0R9D3
db: uniprot

Actin
type: DnaReference
xref: PTHR11937:SF389
organism: Danio rerio

Actin, gamma-enteric smooth muscle
type: DnaReference
xref: PTHR11937:SF445
organism: Homo sapiens

Smad4
type: Protein
entity reference: Smad4
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 sa51 2242
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Axin
type: Protein
entity reference: Axin
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 sa38 2226
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Actin, alpha cardiac muscle 1
type: DnaReference
xref: PTHR11937:SF176
organism: Homo sapiens

uniprot H2QQP7 793
type: UnificationXref
id: H2QQP7
db: uniprot

uniprot Q99717 1556
type: UnificationXref
id: Q99717
db: uniprot

Wnt Target Genes
type: DnaRegionReference
member entity reference: Uncharacterized protein
member entity reference: Homeobox protein engrailed-1a
member entity reference: Axin 1
member entity reference: Xenbase XB-GENE-1031985
member entity reference: Myc proto-oncogene protein
member entity reference: Homeobox protein engrailed-like
member entity reference: Transcription factor 7-like 2
member entity reference: Matrilysin
member entity reference: Axin 2
member entity reference: Axin-1
member entity reference: Peroxisome proliferator activated receptor delta, isoform CRA_b
member entity reference: Ensembl ENSGALG00000007555
member entity reference: ZFIN ZDB-GENE-990415-162
member entity reference: G1/S-specific cyclin-D1
member entity reference: AGAP004661-PA
member entity reference: Ensembl ENSMODG00000015573
member entity reference: MYCL proto-oncogene, bHLH transcription factor
member entity reference: RGD_69259
member entity reference: G1/S-specific cyclin-D
member entity reference: EnsemblGenome SPU 007013
member entity reference: Axin-2
member entity reference: TCF7L1 isoform 2
member entity reference: Ensembl ENSCAFG00000011236
member entity reference: N-myc proto-oncogene protein
member entity reference: T-box transcription factor T
member entity reference: Ensembl ENSCAFG00000000807
member entity reference: Peroxisome proliferator-activated receptor delta
member entity reference: MMP7 isoform 1
member entity reference: Protein L-Myc
member entity reference: Homeobox protein engrailed-1
member entity reference: RGD_1584995
member entity reference: Transcription factor 7-like 1
member entity reference: MYCN proto-oncogene, bHLH transcription factor
member entity reference: ZFIN ZDB-GENE-980605-30
member entity reference: RGD_1584970
member entity reference: WormBase WBGene00000439
member entity reference: Homeobox protein engrailed-2
member entity reference: RGD_1310141
member entity reference: TCF7 isoform 6
member entity reference: Homeobox protein invected
member entity reference: T isoform 1
member entity reference: MGI MGI:101884
member entity reference: EnsemblGenome AGAP002123
member entity reference: Ensembl ENSMMUG00000017047
member entity reference: Homeotic protein ultrabithorax
member entity reference: Segmentation polarity homeobox protein engrailed
member entity reference: Protein B-Myc
member entity reference: PPARD isoform 1
member entity reference: Homeobox protein engrailed-2a
member entity reference: RGD_620859

Danio rerio
type: BioSource
xref: ncbitaxon 7955 73

HETERODIMER_ASSOCIATION_LEFT__Complex__TCF_Smad4_-_Beta_Catenin-RIGHT__Complex__TCF_Smad4__Beta_Catenin_-_r63
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 2463
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 2465
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 2464
left: Complex (TCF/Smad4)
left: Beta-Catenin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TCF/Smad4/ Beta-Catenin)

At3g01890
type: ProteinReference
xref: PTHR13844:SF7
xref: uniprot Q147F4 378
organism: Arabidopsis thaliana

Protein mom-2
type: ProteinReference
xref: PTHR12027:SF3
xref: uniprot Q10459 1254
organism: Caenorhabditis elegans

Protein Wnt
type: ProteinReference
xref: uniprot F7DI28 1187
xref: PTHR12027:SF87
organism: Xenopus tropicalis

uniprot A0A2I3RHK0 1786
type: UnificationXref
id: A0A2I3RHK0
db: uniprot

Protein Wnt-10b
type: ProteinReference
xref: uniprot O00744 1212
xref: PTHR12027:SF76
organism: Homo sapiens

uniprot Q92769 2098
type: UnificationXref
id: Q92769
db: uniprot

Histone deacetylase 3
type: ProteinReference
xref: uniprot Q28DV3 2083
xref: PTHR10625:SF201
organism: Xenopus tropicalis

Frizzled class receptor 4
type: ProteinReference
xref: uniprot F7F2K2 101
xref: PTHR11309:SF23
organism: 9258

Actin, alpha skeletal muscle
type: DnaReference
xref: PTHR11937:SF193
organism: Homo sapiens

Protein kinase gsk3
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot Q10452 1024
organism: 284812

Frizzled-related protein 2
type: ProteinReference
xref: PTHR11309:SF133
xref: uniprot Q6F2E8 1887
organism: Xenopus tropicalis

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
type: ProteinReference
xref: PTHR13844:SF2
xref: uniprot O54772 345
organism: Rattus norvegicus

Complex (Adenomatous Polyposis Coli/Axin/ PP2A/Diversin/ Casein Kinase 1/Beta-Catenin/ betaTrCP/Glycogen Synthase Kinase-3Beta)
type: Complex
component stoichiometry: Casein Kinase 1 s182 sa99 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta Catenin s184 sa100 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glycogen Synthase Kinase 3Beta s186 sa102 STOICHIOMETRY ID COMPLEX
component stoichiometry: Diversin s181 sa98 STOICHIOMETRY ID COMPLEX
component stoichiometry: betaTrCP s185 sa101 STOICHIOMETRY ID COMPLEX
component stoichiometry: PP2A s180 sa97 STOICHIOMETRY ID COMPLEX
component stoichiometry: Adenomatous Polyposis Coli s177 sa95 STOICHIOMETRY ID COMPLEX
component stoichiometry: Axin s178 sa96 STOICHIOMETRY ID COMPLEX
component: Casein Kinase 1
component: Adenomatous Polyposis Coli s177 sa95
component: betaTrCP s185 sa101
component: Axin s178 sa96
component: Glycogen Synthase Kinase-3Beta
component: Diversin
component: Beta-Catenin
component: PP2A
feature: COMPLEX BINDING FEATURE s259 a539 2107
feature: COMPLEX BINDING FEATURE s259 a539 2121
feature: COMPLEX BINDING FEATURE s259 a539 2111
feature: COMPLEX BINDING FEATURE s259 a539 2117
feature: COMPLEX BINDING FEATURE s259 a539 2119
feature: COMPLEX BINDING FEATURE s259 a539 2115
feature: COMPLEX BINDING FEATURE s259 a539 2109
feature: COMPLEX BINDING FEATURE s259 a539 2113
cellular location: plasma membrane

uniprot P67775 573
type: UnificationXref
id: P67775
db: uniprot

Protocadherin 19
type: ProteinReference
xref: PTHR24028:SF40
xref: uniprot A0A3Q1LJ38 653
organism: Bos taurus

Frizzled class receptor 7
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot D4ACM8 76
organism: Rattus norvegicus

FlaMIngo (Cadherin plus 7TM domain) homolog
type: ProteinReference
xref: uniprot G5EDK5 785
xref: PTHR24026:SF105
organism: Caenorhabditis elegans

uniprot Q62074 1702
type: UnificationXref
id: Q62074
db: uniprot

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
type: ProteinReference
xref: PTHR10799:SF76
xref: uniprot F7CAF6 311
organism: Monodelphis domestica

S-arrestin
type: ProteinReference
xref: PTHR11792:SF15
xref: uniprot P15887 1576
organism: Rattus norvegicus

Actin, aortic smooth muscle
type: DnaReference
xref: PTHR11937:SF201
organism: Homo sapiens

uniprot F7G1K7 1447
type: UnificationXref
id: F7G1K7
db: uniprot

PTHR12802:SF9
type: RelationshipXref
id: PTHR12802:SF9
db: PANTHER Family
relationship type: By Homology

Axin-2
type: DnaReference
xref: PTHR46102:SF1
organism: Danio rerio

Axin-1
type: DnaReference
xref: PTHR46102:SF3
organism: Danio rerio

uniprot O96863 1742
type: UnificationXref
id: O96863
db: uniprot

uniprot Q91Y02 921
type: UnificationXref
id: Q91Y02
db: uniprot

PTHR45615:SF6
type: RelationshipXref
id: PTHR45615:SF6
db: PANTHER Family
relationship type: By Homology

Probable helicase HelZ
type: ProteinReference
xref: uniprot I6YCF3 335
xref: PTHR10799:SF987
organism: Mycobacterium tuberculosis

PTHR45615:SF1
type: RelationshipXref
id: PTHR45615:SF1
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF2
type: RelationshipXref
id: PTHR45615:SF2
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF3
type: RelationshipXref
id: PTHR45615:SF3
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
type: ProteinReference
xref: PTHR10257:SF3
xref: uniprot Q10428 577
organism: 284812

Segment polarity protein dishevelled homolog DVL-3
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot Q92997 1397
organism: Homo sapiens

uniprot Q7Q3K5 885
type: UnificationXref
id: Q7Q3K5
db: uniprot

uniprot F1LLX7 228
type: UnificationXref
id: F1LLX7
db: uniprot

uniprot H2Q569 1202
type: UnificationXref
id: H2Q569
db: uniprot

Histone acetyltransferase HAC12
type: ProteinReference
xref: PTHR13808:SF28
xref: uniprot Q9FWQ5 1415
organism: Arabidopsis thaliana

uniprot A0A1D5QZ34 631
type: UnificationXref
id: A0A1D5QZ34
db: uniprot

Calcineurin subunit B
type: ProteinReference
xref: uniprot P25296 1327
xref: PTHR45942:SF1
organism: Saccharomyces cerevisiae

Myosin-7
type: DnaReference
xref: PTHR45615:SF1
organism: Mus musculus

Casein kinase 1, alpha 1
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot Q8JHE0 1850
organism: Danio rerio

PTHR11937:SF477
type: RelationshipXref
id: PTHR11937:SF477
db: PANTHER Family
relationship type: By Homology

uniprot P22082 353
type: UnificationXref
id: P22082
db: uniprot

uniprot F4IHS2 294
type: UnificationXref
id: F4IHS2
db: uniprot

Smad4
type: ProteinReference
xref: P01455
standard name: Mothers against decapentaplegic homolog 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Wnt signaling pathway.PROTEIN.GENERIC.Smad4
comment: ENTITY_REFERENCE_NOTES= Long Name: Mothers against decapentaplegic homolog 4 Synonym: MAD homolog 1,MAD homolog 4,Mothers against decapentaplegic homolog 1,Mothers against decapentaplegic homolog 4,Smad1 Accession: P01455
member entity reference: Mothers against decapentaplegic homolog 1
member entity reference: Mothers against decapentaplegic homolog
member entity reference: Q6DIS7
member entity reference: Mothers against decapentaplegic homolog 4
member entity reference: Mothers against decapentaplegic homolog 5
member entity reference: Q13485
member entity reference: F7F4A2
member entity reference: B0JYL0
member entity reference: Protein mothers against dpp
member entity reference: F7CFQ6

Helicase SWR1
type: ProteinReference
xref: uniprot Q05471 372
xref: PTHR45685:SF1
organism: Saccharomyces cerevisiae

uniprot F7GZ76 772
type: UnificationXref
id: F7GZ76
db: uniprot

uniprot P28548 1750
type: UnificationXref
id: P28548
db: uniprot

SWI/SNF nucleosome remodeling complex component
type: ProteinReference
xref: PTHR12802:SF41
xref: uniprot H8ESF3 333
organism: Caenorhabditis elegans

GBeta s161 sa77 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBeta s161 sa77
stoichiometric coefficient: 1.0

uniprot Q9Y5E5 973
type: UnificationXref
id: Q9Y5E5
db: uniprot

uniprot A0A0G2K0H3 168
type: UnificationXref
id: A0A0G2K0H3
db: uniprot

EDN1 isoform 1
type: DnaReference
xref: PTHR13874:SF10
organism: Pan troglodytes

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot O57328 113
organism: 9031

PTHR24027:SF99
type: RelationshipXref
id: PTHR24027:SF99
db: PANTHER Family
relationship type: By Homology

uniprot F6UY89 727
type: UnificationXref
id: F6UY89
db: uniprot

T-box transcription factor T-A
type: DnaReference
xref: PTHR11267:SF169
organism: Danio rerio

Uncharacterized protein
type: DnaReference
xref: PTHR45615:SF1
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HLC0 774
xref: PTHR24026:SF42
organism: Macaca mulatta

uniprot Q8TAB3 899
type: UnificationXref
id: Q8TAB3
db: uniprot

G protein alpha q subunit
type: ProteinReference
xref: uniprot P23625 1455
xref: PTHR10218:SF329
organism: Drosophila melanogaster

uniprot F1MDE1 172
type: UnificationXref
id: F1MDE1
db: uniprot

uniprot P29387 1621
type: UnificationXref
id: P29387
db: uniprot

uniprot Q7T2E3 1845
type: UnificationXref
id: Q7T2E3
db: uniprot

uniprot P26308 1620
type: UnificationXref
id: P26308
db: uniprot

Threonine41 Beta Catenin s184 sa100 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s184 sa100 rs4 Threonine41
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot F7C1G3 1803
organism: Monodelphis domestica

PTHR23194:SF16
type: RelationshipXref
id: PTHR23194:SF16
db: PANTHER Family
relationship type: By Homology

Wnt s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Wnt s3 sa1
stoichiometric coefficient: 1.0

Chromodomain helicase DNA-binding protein 1-like
type: ProteinReference
xref: PTHR47157:SF1
xref: uniprot D4ACG6 275
organism: Rattus norvegicus

uniprot Q9DC28 1863
type: UnificationXref
id: Q9DC28
db: uniprot

uniprot Q12968 1484
type: UnificationXref
id: Q12968
db: uniprot

Threonine41 Beta Catenin s138 sa123 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Threonine41
feature location: Threonine41 Beta Catenin s138 sa123 rs4 Threonine41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3516871836592173
comment: MODIFICATION_RESIDUE_NAME=Threonine41

uniprot O64816 1737
type: UnificationXref
id: O64816
db: uniprot

Serine45 Beta Catenin s270 a146 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Serine45
feature location: Serine45 Beta Catenin s270 a146 rs1 Serine45
comment: MODIFICATION_RESIDUE_ANGLE=3.937932896663057
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Serine45

Siah 1 s19 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Siah 1 s19 sa9
stoichiometric coefficient: 1.0

Nemo like Kinase s199 a451 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7C5Z9 552
type: UnificationXref
id: F7C5Z9
db: uniprot

Adenylosuccinate synthetase isozyme 2
type: DnaReference
xref: PTHR11846:SF13
organism: Bos taurus

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: uniprot O14640 1388
xref: PTHR10878:SF5
organism: Homo sapiens