ncbitaxon 224324 21
type: UnificationXref
id: 224324
db: ncbitaxon

uniprot P76641 86
type: UnificationXref
id: P76641
db: uniprot

Purine nucleoside phosphorylase
type: ProteinReference
xref: PTHR11904:SF12
xref: uniprot Q9D8C9 75
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r3 100
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

uniprot Q9I3J2 91
type: UnificationXref
id: Q9I3J2
db: uniprot

eco ECO:0000250 60
type: UnificationXref
id: ECO:0000250
db: eco

STATE_TRANSITION_LEFT__H2O-_guanine-RIGHT__xanthine-_NH3-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 124
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 123
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 125
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 122
left: H2O
left: guanine
interaction type: STATE_TRANSITION
right: NH3
right: xanthine

STATE_TRANSITION_LEFT__deoxyribose_1_phosphate-_guanine-RIGHT__PO4-_deoxyguanosine-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 113
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 111
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 110
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 112
left: guanine
left: deoxyribose-1-phosphate
interaction type: STATE_TRANSITION
right: PO4
right: deoxyguanosine

ncbitaxon 7165 63
type: UnificationXref
id: 7165
db: ncbitaxon

ncbitaxon 284812 78
type: UnificationXref
id: 284812
db: ncbitaxon

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 63

PARTICIPANT STOICHIOMETRY r3 101
type: Stoichiometry
physical entity: GMP
stoichiometric coefficient: 1.0

Probable guanine deaminase
type: ProteinReference
xref: uniprot O14057 85
organism: Schizosaccharomyces pombe

Guanine deaminase
type: ProteinReference
xref: P03249
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Guanine deaminase Synonym: Synonym not specified Accession: P03249
comment: ENTITY_REFERENCE_ID_DESC=Xanthine and guanine salvage pathway.PROTEIN.GENERIC.Guanine deaminase
member entity reference: Guanine deaminase
member entity reference: Probable guanine deaminase

ncbitaxon 9615 39
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot F6T0Z6 65
type: UnificationXref
id: F6T0Z6
db: uniprot

Xanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q4QCC2 35
organism: Leishmania major

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q4QCC3 37
organism: Leishmania major

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 56

ncbitaxon 243274 56
type: UnificationXref
id: 243274
db: ncbitaxon

ncbitaxon 100226 58
type: UnificationXref
id: 100226
db: ncbitaxon

Probable guanine deaminase
type: ProteinReference
xref: uniprot Q07729 88
organism: Saccharomyces cerevisiae

Mus musculus
type: BioSource
xref: ncbitaxon 10090 25

ncbitaxon 9913 19
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot B2RYS6 11
type: UnificationXref
id: B2RYS6
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9X8I5 57
organism: Streptomyces coelicolor

uniprot Q9WTT6 96
type: UnificationXref
id: Q9WTT6
db: uniprot

ncbitaxon 10116 12
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot F7AT83 16
type: UnificationXref
id: F7AT83
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 74

uniprot O14057 85
type: UnificationXref
id: O14057
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 68

Guanine phosphoribosyl transferase
type: ProteinReference
xref: P03245
standard name: Guanine phosphoribosyltransferase
comment: ENTITY_REFERENCE_ID_DESC=Xanthine and guanine salvage pathway.PROTEIN.GENERIC.Guanine phosphoribosyl_br_transferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Guanine phosphoribosyltransferase Synonym: Synonym not specified Accession: P03245
member entity reference: Hypoxanthine-guanine phosphoribosyltransferase
member entity reference: Probable purine/pyrimidine phosphoribosyl transferase
member entity reference: Hypoxanthine phosphoribosyltransferase
member entity reference: Xanthine phosphoribosyltransferase
member entity reference: Phosphoribosyltransferase domain-containing protein 1

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 60

uniprot Q38CA0 33
type: UnificationXref
id: Q38CA0
db: uniprot

uniprot Q9WY49 55
type: UnificationXref
id: Q9WY49
db: uniprot

PTHR11904:SF12
type: RelationshipXref
id: PTHR11904:SF12
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7227 68
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot U4PSA1 81
type: UnificationXref
id: U4PSA1
db: uniprot

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P9WHQ9 29
organism: Mycobacterium tuberculosis

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q38CA0 33
organism: Trypanosoma brucei

uniprot P9WP01 72
type: UnificationXref
id: P9WP01
db: uniprot

PARTICIPANT STOICHIOMETRY r2 104
type: Stoichiometry
physical entity: GMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 105
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 102
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 103
type: Stoichiometry
physical entity: guanosine
stoichiometric coefficient: 1.0

uniprot A0A2R8QRE7 6
type: UnificationXref
id: A0A2R8QRE7
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A8XWA1 9
organism: Caenorhabditis briggsae

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P27605 26
organism: Rattus norvegicus

uniprot F6YAY4 15
type: UnificationXref
id: F6YAY4
db: uniprot

AGAP005945-PA
type: ProteinReference
xref: uniprot A4Q998 62
organism: Anopheles gambiae

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot A0A452DJA8 59
xref: PTHR11904:SF12
organism: Bos taurus

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 90

uniprot Q9X259 80
type: UnificationXref
id: Q9X259
db: uniprot

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 43

Guanine phosphoribosyl transferase
type: Protein
entity reference: Guanine phosphoribosyl transferase
comment: SPECIES_TYPE=PROTEIN

uniprot F4IA25 13
type: UnificationXref
id: F4IA25
db: uniprot

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 41

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot F6YAY4 15
organism: Macaca mulatta

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine deaminase
type: ProteinReference
xref: uniprot P76641 86
organism: Escherichia coli

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 78

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__xanthine-_PRPP-RIGHT__PPi-_xanthosine_5_phosphate-_r6
controller: Xanthine phosphoribosyl transferase

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot P23492 70
xref: PTHR11904:SF12
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_guanine-RIGHT__xanthine-_NH3-_r4
controller: Guanine deaminase

ncbitaxon 190304 45
type: UnificationXref
id: 190304
db: ncbitaxon

ncbitaxon 9031 54
type: UnificationXref
id: 9031
db: ncbitaxon

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q9X259 80
organism: Thermotoga maritima

uniprot Q4QCC3 37
type: UnificationXref
id: Q4QCC3
db: uniprot

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q9X1T2 79
organism: Thermotoga maritima

uniprot Q05788 73
type: UnificationXref
id: Q05788
db: uniprot

uniprot P00493 24
type: UnificationXref
id: P00493
db: uniprot

uniprot A0A2I3TEX9 4
type: UnificationXref
id: A0A2I3TEX9
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 5

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot F4IA25 13
organism: Arabidopsis thaliana

Guanine deaminase
type: ProteinReference
xref: uniprot Q9VMY9 95
organism: Drosophila melanogaster

ncbitaxon 185431 32
type: UnificationXref
id: 185431
db: ncbitaxon

Guanine deaminase
type: ProteinReference
xref: PTHR11271:SF6
xref: uniprot Q9WTT6 96
organism: Rattus norvegicus

Guanine deaminase
type: ProteinReference
xref: uniprot Q1K8M4 89
organism: Neurospora crassa

uniprot A5A6I1 8
type: UnificationXref
id: A5A6I1
db: uniprot

uniprot Q9D8C9 75
type: UnificationXref
id: Q9D8C9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__deoxyribose_1_phosphate-_guanine-RIGHT__PO4-_deoxyguanosine-_r7
controller: Deoxyguanosine phosphorylase

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 52

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 23

ncbitaxon 83332 30
type: UnificationXref
id: 83332
db: ncbitaxon

Guanine deaminase
type: ProteinReference
xref: PTHR11271:SF6
xref: uniprot Q9Y2T3 97
organism: Homo sapiens

Guanine deaminase
type: ProteinReference
xref: PTHR11271:SF6
xref: uniprot Q9I6Z8 92
organism: Pseudomonas aeruginosa

uniprot A8XI15 64
type: UnificationXref
id: A8XI15
db: uniprot

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot P00491 69
organism: Homo sapiens

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P00492 22
organism: Homo sapiens

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P00493 24
organism: Mus musculus

Guanine deaminase
type: ProteinReference
xref: PTHR11271:SF6
xref: uniprot Q9R111 93
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PO4-_xanthosine-RIGHT__ribose_1_phosphate-_xanthine-_r5
controller: Xanthosine phosphorylase

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 14

uniprot P9WHQ9 29
type: UnificationXref
id: P9WHQ9
db: uniprot

uniprot Q3SZ18 34
type: UnificationXref
id: Q3SZ18
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8RGK5 44
organism: Fusobacterium nucleatum

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9RUK8 51
organism: Deinococcus radiodurans

uniprot Q8IJS1 42
type: UnificationXref
id: Q8IJS1
db: uniprot

uniprot Q9EWV2 76
type: UnificationXref
id: Q9EWV2
db: uniprot

uniprot F7CWR5 84
type: UnificationXref
id: F7CWR5
db: uniprot

uniprot A0A1D5RJY6 2
type: UnificationXref
id: A0A1D5RJY6
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 30

ncbitaxon 3702 14
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot F1MLX9 83
type: UnificationXref
id: F1MLX9
db: uniprot

xanthosine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot G3N0T0 18
type: UnificationXref
id: G3N0T0
db: uniprot

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot P9WP01 72
organism: Mycobacterium tuberculosis

PARTICIPANT STOICHIOMETRY r1 106
type: Stoichiometry
physical entity: ribose-1-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 107
type: Stoichiometry
physical entity: guanine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 108
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 109
type: Stoichiometry
physical entity: guanosine
stoichiometric coefficient: 1.0

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 87

Danio rerio
type: BioSource
xref: ncbitaxon 7955 7

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot O66821 20
organism: Aquifex aeolicus

deoxyribose-1-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__xanthine-_PRPP-RIGHT__PPi-_xanthosine_5_phosphate-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 117
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 114
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 115
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 116
left: PRPP
left: xanthine
interaction type: STATE_TRANSITION
right: xanthosine-5-phosphate
right: PPi

uniprot Q9HVE7 46
type: UnificationXref
id: Q9HVE7
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9WY49 55
organism: Thermotoga maritima

STATE_TRANSITION_LEFT__ATP-_guanosine-RIGHT__GMP-_ADP-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 103
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 105
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 104
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 102
left: guanosine
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: GMP

uniprot Q9VMY9 95
type: UnificationXref
id: Q9VMY9
db: uniprot

STATE_TRANSITION_LEFT__PO4-_xanthosine-RIGHT__ribose_1_phosphate-_xanthine-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 119
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 118
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 121
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 120
left: PO4
left: xanthosine
interaction type: STATE_TRANSITION
right: ribose-1-phosphate
right: xanthine

Probable guanine deaminase
type: ProteinReference
xref: uniprot Q9RYX4 94
organism: Deinococcus radiodurans

Guanine deaminase
type: ProteinReference
xref: uniprot F1MLX9 83
organism: Bos taurus

Deoxyguanosine phosphorylase
type: ProteinReference
xref: P03248
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Deoxyguanosine phosphorylase Synonym: Synonym not specified Accession: P03248
comment: ENTITY_REFERENCE_ID_DESC=Xanthine and guanine salvage pathway.PROTEIN.GENERIC.Deoxyguanosine_br_phosphorylase
member entity reference: Purine nucleoside phosphorylase
member entity reference: AGAP005945-PA
member entity reference: Putative purine nucleoside phosphorylase
member entity reference: Purine nucleoside phosphorylase 1
member entity reference: Uncharacterized protein, isoform H

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 243230 52
type: UnificationXref
id: 243230
db: ncbitaxon

Guanine deaminase
type: ProteinReference
xref: uniprot F7CWR5 84
xref: PTHR11271:SF6
organism: Macaca mulatta

uniprot Q9Y2T3 97
type: UnificationXref
id: Q9Y2T3
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot G3N0T0 18
organism: Bos taurus

ribose-1-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Xanthosine phosphorylase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot O66821 20
type: UnificationXref
id: O66821
db: uniprot

uniprot Q9R111 93
type: UnificationXref
id: Q9R111
db: uniprot

uniprot Q8RGK5 44
type: UnificationXref
id: Q8RGK5
db: uniprot

Probable purine/pyrimidine phosphoribosyl transferase
type: ProteinReference
xref: uniprot Q9HVE7 46
organism: Pseudomonas aeruginosa

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q38C93 31
organism: Trypanosoma brucei

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q3SZ18 34
organism: Bos taurus

ncbitaxon 5664 36
type: UnificationXref
id: 5664
db: ncbitaxon

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9W719 53
type: UnificationXref
id: Q9W719
db: uniprot

uniprot Q07729 88
type: UnificationXref
id: Q07729
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9NF11 48
organism: Caenorhabditis elegans

uniprot P00491 69
type: UnificationXref
id: P00491
db: uniprot

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P37472 27
organism: Bacillus subtilis

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 28

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 45

deoxyguanosine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 559292 74
type: UnificationXref
id: 559292
db: ncbitaxon

Bos taurus
type: BioSource
xref: ncbitaxon 9913 19

guanosine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 3

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 17

uniprot M9PE19 67
type: UnificationXref
id: M9PE19
db: uniprot

Xanthine and guanine salvage pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__ribose_1_phosphate-_guanine-RIGHT__PO4-_guanosine-_r1
pathway component: STATE_TRANSITION_LEFT__xanthine-_PRPP-RIGHT__PPi-_xanthosine_5_phosphate-_r6
pathway component: STATE_TRANSITION_LEFT__PRPP-_guanine-RIGHT__PPi-_GMP-_r3
pathway component: STATE_TRANSITION_LEFT__PO4-_xanthosine-RIGHT__ribose_1_phosphate-_xanthine-_r5
pathway component: STATE_TRANSITION_LEFT__ATP-_guanosine-RIGHT__GMP-_ADP-_r2
pathway component: STATE_TRANSITION_LEFT__deoxyribose_1_phosphate-_guanine-RIGHT__PO4-_deoxyguanosine-_r7
pathway component: STATE_TRANSITION_LEFT__H2O-_guanine-RIGHT__xanthine-_NH3-_r4
xref: PANTHER Pathway P02788 1
comment: MODEL_NOTES= Purine nucleosides can be synthesize in two ways, de novo biosynthesis and salvaging pathways. In salvaging pathways nucleosides from RNA and DNA breakdown can reenter purine nucleoside de novo biosynthesis. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 32

ncbitaxon 224308 28
type: UnificationXref
id: 224308
db: ncbitaxon

uniprot Q4QCC2 35
type: UnificationXref
id: Q4QCC2
db: uniprot

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot H2Q7W4 66
organism: Pan troglodytes

PRPP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

NH3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A4Q998 62
type: UnificationXref
id: A4Q998
db: uniprot

ncbitaxon 226186 41
type: UnificationXref
id: 226186
db: ncbitaxon

xanthine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

xanthosine-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 7955 7
type: UnificationXref
id: 7955
db: ncbitaxon

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q89ZJ1 40
organism: Bacteroides thetaiotaomicron

uniprot P27605 26
type: UnificationXref
id: P27605
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 12

uniprot P46354 71
type: UnificationXref
id: P46354
db: uniprot

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 21

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__PRPP-_guanine-RIGHT__PPi-_GMP-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 101
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 100
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 99
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 98
left: PRPP
left: guanine
interaction type: STATE_TRANSITION
right: PPi
right: GMP

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 39

Xanthine phosphoribosyl transferase
type: ProteinReference
xref: P03247
standard name: Xanthine phosphoribosyltransferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Xanthine and guanine salvage pathway.PROTEIN.GENERIC.Xanthine phosphoribosyl_br_transferase
comment: ENTITY_REFERENCE_NOTES= Long Name: Xanthine phosphoribosyltransferase Synonym: Synonym not specified Accession: P03247
member entity reference: Hypoxanthine-guanine phosphoribosyltransferase
member entity reference: Probable purine/pyrimidine phosphoribosyl transferase
member entity reference: Hypoxanthine phosphoribosyltransferase
member entity reference: Xanthine phosphoribosyltransferase
member entity reference: Phosphoribosyltransferase domain-containing protein 1

uniprot Q9X1T2 79
type: UnificationXref
id: Q9X1T2
db: uniprot

PARTICIPANT STOICHIOMETRY r5 120
type: Stoichiometry
physical entity: ribose-1-phosphate
stoichiometric coefficient: 1.0

By Homology
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r5 121
type: Stoichiometry
physical entity: xanthine
stoichiometric coefficient: 1.0

Guanine deaminase
type: ProteinReference
xref: PTHR11271:SF6
xref: uniprot Q9I3J2 91
organism: Pseudomonas aeruginosa

uniprot P37472 27
type: UnificationXref
id: P37472
db: uniprot

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q9EWV2 76
organism: Streptomyces coelicolor

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 54

STATE_TRANSITION_LEFT__ribose_1_phosphate-_guanine-RIGHT__PO4-_guanosine-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 107
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 108
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 109
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 106
left: ribose-1-phosphate
left: guanine
interaction type: STATE_TRANSITION
right: PO4
right: guanosine

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot F7AT83 16
organism: Ornithorhynchus anatinus

uniprot Q9I6Z8 92
type: UnificationXref
id: Q9I6Z8
db: uniprot

GMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9606 23
type: UnificationXref
id: 9606
db: ncbitaxon

ncbitaxon 10090 25
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot Q9X8I5 57
type: UnificationXref
id: Q9X8I5
db: uniprot

uniprot H2Q7W4 66
type: UnificationXref
id: H2Q7W4
db: uniprot

ncbitaxon 36329 43
type: UnificationXref
id: 36329
db: ncbitaxon

Guanosine phosphorylase
type: ProteinReference
xref: P03250
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Xanthine and guanine salvage pathway.PROTEIN.GENERIC.Guanosine phosphorylase
comment: ENTITY_REFERENCE_NOTES= Long Name: Guanosine phosphorylase Synonym: Synonym not specified Accession: P03250
member entity reference: Purine nucleoside phosphorylase
member entity reference: AGAP005945-PA
member entity reference: Putative purine nucleoside phosphorylase
member entity reference: Purine nucleoside phosphorylase 1
member entity reference: Uncharacterized protein, isoform H

uniprot P23492 70
type: UnificationXref
id: P23492
db: uniprot

ncbitaxon 9544 3
type: UnificationXref
id: 9544
db: ncbitaxon

ncbitaxon 9598 5
type: UnificationXref
id: 9598
db: ncbitaxon

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A0A2I3TEX9 4
organism: Pan troglodytes

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 58

PARTICIPANT STOICHIOMETRY r3 98
type: Stoichiometry
physical entity: PRPP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 99
type: Stoichiometry
physical entity: guanine
stoichiometric coefficient: 1.0

Deoxyguanosine phosphorylase
type: Protein
entity reference: Deoxyguanosine phosphorylase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r4 124
type: Stoichiometry
physical entity: xanthine
stoichiometric coefficient: 1.0

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q05788 73
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r4 125
type: Stoichiometry
physical entity: NH3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 122
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 119
type: Stoichiometry
physical entity: xanthosine
stoichiometric coefficient: 1.0

uniprot Q38C93 31
type: UnificationXref
id: Q38C93
db: uniprot

PARTICIPANT STOICHIOMETRY r4 123
type: Stoichiometry
physical entity: guanine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 118
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

uniprot P00492 22
type: UnificationXref
id: P00492
db: uniprot

P03247
type: UnificationXref
id: P03247
db: PANTHER Pathway Component

P03248
type: UnificationXref
id: P03248
db: PANTHER Pathway Component

ncbitaxon 9258 17
type: UnificationXref
id: 9258
db: ncbitaxon

P03245
type: UnificationXref
id: P03245
db: PANTHER Pathway Component

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q9RYX4 94
type: UnificationXref
id: Q9RYX4
db: uniprot

PARTICIPANT STOICHIOMETRY r6 115
type: Stoichiometry
physical entity: PRPP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 116
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot A8XI15 64
organism: Caenorhabditis briggsae

PARTICIPANT STOICHIOMETRY r6 114
type: Stoichiometry
physical entity: xanthine
stoichiometric coefficient: 1.0

P03249
type: UnificationXref
id: P03249
db: PANTHER Pathway Component

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q6WIT9 38
organism: Canis lupus familiaris

Xanthine phosphoribosyl transferase
type: Protein
entity reference: Xanthine phosphoribosyl transferase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r7 111
type: Stoichiometry
physical entity: guanine
stoichiometric coefficient: 1.0

uniprot Q89ZJ1 40
type: UnificationXref
id: Q89ZJ1
db: uniprot

PARTICIPANT STOICHIOMETRY r7 110
type: Stoichiometry
physical entity: deoxyribose-1-phosphate
stoichiometric coefficient: 1.0

ncbitaxon 83333 87
type: UnificationXref
id: 83333
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r7 113
type: Stoichiometry
physical entity: deoxyguanosine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 112
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 117
type: Stoichiometry
physical entity: xanthosine-5-phosphate
stoichiometric coefficient: 1.0

P03250
type: UnificationXref
id: P03250
db: PANTHER Pathway Component

uniprot Q9UTG1 77
type: UnificationXref
id: Q9UTG1
db: uniprot

Putative purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q9UTG1 77
organism: Schizosaccharomyces pombe

uniprot A0A2I3S7K0 82
type: UnificationXref
id: A0A2I3S7K0
db: uniprot

ncbitaxon 6238 10
type: UnificationXref
id: 6238
db: ncbitaxon

Phosphoribosyltransferase domain-containing protein 1
type: ProteinReference
xref: uniprot Q9NRG1 50
organism: Homo sapiens

Guanine deaminase
type: Protein
entity reference: Guanine deaminase
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ribose_1_phosphate-_guanine-RIGHT__PO4-_guanosine-_r1
controller: Guanosine phosphorylase

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A0A2R8QRE7 6
organism: Danio rerio

uniprot Q9NF11 48
type: UnificationXref
id: Q9NF11
db: uniprot

uniprot Q9RUK8 51
type: UnificationXref
id: Q9RUK8
db: uniprot

ncbitaxon 208964 47
type: UnificationXref
id: 208964
db: ncbitaxon

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot B2RYS6 11
organism: Rattus norvegicus

Uncharacterized protein, isoform H
type: ProteinReference
xref: uniprot M9PE19 67
organism: Drosophila melanogaster

Leishmania major
type: BioSource
xref: ncbitaxon 5664 36

Guanine deaminase
type: ProteinReference
xref: uniprot A0A2I3S7K0 82
xref: PTHR11271:SF6
organism: Pan troglodytes

Guanosine kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Guanosine phosphorylase
type: Protein
entity reference: Guanosine phosphorylase
comment: SPECIES_TYPE=PROTEIN

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 10

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8IJS1 42
organism: Plasmodium falciparum

uniprot A8XWA1 9
type: UnificationXref
id: A8XWA1
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 49

Purine nucleoside phosphorylase 1
type: ProteinReference
xref: uniprot P46354 71
organism: Bacillus subtilis

PTHR11271:SF6
type: RelationshipXref
id: PTHR11271:SF6
db: PANTHER Family
relationship type: By Homology

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot U4PSA1 81
organism: Caenorhabditis elegans

uniprot Q1K8M4 89
type: UnificationXref
id: Q1K8M4
db: uniprot

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A5A6I1 8
organism: Pan troglodytes

uniprot A0A452DJA8 59
type: UnificationXref
id: A0A452DJA8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_guanosine-RIGHT__GMP-_ADP-_r2
controller: Guanosine kinase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRPP-_guanine-RIGHT__PPi-_GMP-_r3
controller: Guanine phosphoribosyl transferase

ncbitaxon 367110 90
type: UnificationXref
id: 367110
db: ncbitaxon

guanine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PANTHER Pathway P02788 1
type: UnificationXref
id: P02788
db: PANTHER Pathway

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9W719 53
organism: Gallus gallus

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A0A1D5RJY6 2
organism: Macaca mulatta

uniprot Q9NRG1 50
type: UnificationXref
id: Q9NRG1
db: uniprot

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot F6T0Z6 65
organism: Macaca mulatta

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 47

uniprot Q6WIT9 38
type: UnificationXref
id: Q6WIT9
db: uniprot

ncbitaxon 6239 49
type: UnificationXref
id: 6239
db: ncbitaxon