Exon-1
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 a66 92
comment: SPECIES_TYPE=RNA

uniprot Q5U214 65
type: UnificationXref
id: Q5U214
db: uniprot

Small nuclear ribonucleoprotein U5 subunit 40
type: ProteinReference
xref: PTHR44006:SF1
xref: uniprot F1NUK8 29
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r23 201
type: Stoichiometry
physical entity: Complex (U2AF35/U2AF65)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 200
type: Stoichiometry
physical entity: U2AF35
stoichiometric coefficient: 1.0

uniprot Q93339 46
type: UnificationXref
id: Q93339
db: uniprot

Complex U2AF35 U2AF65 s54 a98 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (U2AF35/U2AF65)
stoichiometric coefficient: 1.0

ncbitaxon 9258 54
type: UnificationXref
id: 9258
db: ncbitaxon

U4
type: Protein
entity reference: U4
comment: SPECIES_TYPE=PROTEIN

U2AF65
type: ProteinReference
xref: P01475
comment: ENTITY_REFERENCE_NOTES= Long Name: U2AF65 Synonym: U2AF65-ASSOCIATED PROTEIN,UAP65 Accession: P01475
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=mRNA splicing.PROTEIN.GENERIC.U2AF65
member entity reference: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
member entity reference: ZRSR2 isoform 1
member entity reference: ZRSR1 isoform 1
member entity reference: Putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1

U2AF35
type: ProteinReference
xref: P01477
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: U2AF35 Synonym: U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT,U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1,U2AF1,U2AF35,splicing factor U2AF 35kDa subunit Accession: P01477
comment: ENTITY_REFERENCE_ID_DESC=mRNA splicing.PROTEIN.GENERIC.U2AF35
member entity reference: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
member entity reference: Zinc finger (CCCH type), RNA-binding motif and serine/arginine-rich 1

Zinc finger (CCCH type), RNA-binding motif and serine/arginine-rich 1
type: ProteinReference
xref: uniprot Q5RK33 48
organism: Rattus norvegicus

uniprot F6YE01 53
type: UnificationXref
id: F6YE01
db: uniprot

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
type: ProteinReference
xref: uniprot Q64707 49
organism: Mus musculus

uniprot P09012 63
type: UnificationXref
id: P09012
db: uniprot

uniprot F6SV59 31
type: UnificationXref
id: F6SV59
db: uniprot

uniprot Q62189 66
type: UnificationXref
id: Q62189
db: uniprot

ncbitaxon 9615 7
type: UnificationXref
id: 9615
db: ncbitaxon

U5 s40 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U5
stoichiometric coefficient: 1.0

uniprot A0A2J8MSX5 50
type: UnificationXref
id: A0A2J8MSX5
db: uniprot

PRP3 pre-mRNA processing factor 3 homolog
type: ProteinReference
xref: PTHR14212:SF0
xref: uniprot G2HGL9 14
organism: Pan troglodytes

ncbitaxon 3702 26
type: UnificationXref
id: 3702
db: ncbitaxon

Complex (U2AF35/U2AF65)
type: Complex
component stoichiometry: U2AF65 s64 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2AF35 s65 sa23 STOICHIOMETRY ID COMPLEX
component: U2AF65
component: U2AF35
feature: COMPLEX BINDING FEATURE s60 a95 111
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 a95 126
feature: COMPLEX BINDING FEATURE s60 a95 113

Mus musculus
type: BioSource
xref: ncbitaxon 10090 24

uniprot P43332 59
type: UnificationXref
id: P43332
db: uniprot

U2AF35 s73 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF35
stoichiometric coefficient: 1.0

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 19

ncbitaxon 10090 24
type: UnificationXref
id: 10090
db: ncbitaxon

U2AF35 s88 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF35
stoichiometric coefficient: 1.0

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 60

Complex (Exon-1/intron/Exon-2)
type: Complex
component stoichiometry: Exon 1 s44 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: intron s45 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: Exon 2 s46 sa20 STOICHIOMETRY ID COMPLEX
component: Exon-2
component: intron
component: Exon-1
feature: COMPLEX BINDING FEATURE s58 a85 119
feature: COMPLEX BINDING FEATURE s58 a85 121
feature: COMPLEX BINDING FEATURE s58 a85 123

U2AF65 s89 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF65
stoichiometric coefficient: 1.0

U2
type: Protein
entity reference: U2
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa44 96
comment: SPECIES_TYPE=PROTEIN

Pre-mRNA-processing factor 19
type: ProteinReference
xref: uniprot O14011 42
organism: Schizosaccharomyces pombe

Complex (U2AF35/U2AF65)
type: Complex
component stoichiometry: U2AF35 s73 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2AF65 s74 sa32 STOICHIOMETRY ID COMPLEX
component: U2AF35
component: U2AF65
feature: COMPLEX BINDING FEATURE s72 a99 115
feature: COMPLEX BINDING FEATURE s72 a99 117
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 a99 170

U5 small nuclear ribonucleoprotein 40 kDa protein
type: ProteinReference
xref: PTHR44006:SF1
xref: uniprot Q6PE01 33
organism: Mus musculus

HETERODIMER_ASSOCIATION_LEFT__Complex__Exon_1_intron_Exon_2_-_Complex__U4_U6__U5_-RIGHT__Complex_U6_U4_U2_U5_U1_-_re11
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 188
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 189
left: Complex (Exon-1/intron/Exon-2)
left: Complex (U4/U6/ U5)
interaction type: HETERODIMER_ASSOCIATION
right: Complex(U6/U4/U2/U5/U1)

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 45

Complex (Exon-1/intron/Exon-2)
type: Complex
component stoichiometry: Complex U2AF35 U2AF65 s54 a98 STOICHIOMETRY ID COMPLEX
component stoichiometry: Exon 2 s50 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: intron s49 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Exon 1 s48 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: U1 s68 a14 STOICHIOMETRY ID COMPLEX
component: intron
component: U1
component: Exon-2
component: Complex (U2AF35/U2AF65)
component: Exon-1
feature: COMPLEX BINDING FEATURE s67 a6 139
feature: COMPLEX BINDING FEATURE s67 a6 133
feature: COMPLEX BINDING FEATURE s67 a6 135
feature: COMPLEX BINDING FEATURE s67 a6 137
feature: COMPLEX BINDING FEATURE s67 a6 141

PANTHER Pathway P00058 1
type: UnificationXref
id: P00058
db: PANTHER Pathway

U4 s26 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U4
stoichiometric coefficient: 1.0

Exon-1
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa17 168
comment: SPECIES_TYPE=RNA

U2AF65 s64 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF65
stoichiometric coefficient: 1.0

ncbitaxon 9598 15
type: UnificationXref
id: 9598
db: ncbitaxon

U1 small nuclear ribonucleoprotein A
type: ProteinReference
xref: uniprot P43332 59
organism: Drosophila melanogaster

uniprot Q15696 39
type: UnificationXref
id: Q15696
db: uniprot

ncbitaxon 9606 17
type: UnificationXref
id: 9606
db: ncbitaxon

U2AF65 s57 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF65
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 198
type: Stoichiometry
physical entity: Complex (Exon-1/intron/Exon-2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 197
type: Stoichiometry
physical entity: Complex (Exon-1/intron/Exon-2)
stoichiometric coefficient: 1.0

U6
type: Protein
entity reference: U6
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa45 98
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r24 196
type: Stoichiometry
physical entity: Complex (U2AF35/U2AF65)
stoichiometric coefficient: 1.0

U6 s31 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U6
stoichiometric coefficient: 1.0

U1
type: ProteinReference
xref: P01479
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: U1 Synonym: RNU1,Rnu1a1,U1 SMALL NUCLEAR,snRNA Accession: P01479
comment: ENTITY_REFERENCE_ID_DESC=mRNA splicing.PROTEIN.GENERIC.U1
member entity reference: Small nuclear ribonucleoprotein polypeptide A
member entity reference: U1 small nuclear ribonucleoprotein A

RCG27500, isoform CRA_c
type: ProteinReference
xref: uniprot B5DEQ4 51
organism: Rattus norvegicus

uniprot G5E5Y0 56
type: UnificationXref
id: G5E5Y0
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 15

U2AF65 s74 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF65
stoichiometric coefficient: 1.0

Complex U2AF35 U2AF65 s72 a99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (U2AF35/U2AF65)
stoichiometric coefficient: 1.0

intron
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 a60 90
comment: SPECIES_TYPE=RNA

mRNA splicing
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Exon_1_intron_Exon_2_-_Complex__U4_U6__U5_-RIGHT__Complex_U6_U4_U2_U5_U1_-_re11
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__U6_U4_-_U5-RIGHT__Complex__U4_U6__U5_-_r25
pathway component: STATE_TRANSITION_LEFT__U1-_Complex__Exon_1_intron_Exon_2_-RIGHT__Complex__Exon_1_intron_Exon_2_-_r1
pathway component: STATE_TRANSITION_LEFT__Complex_U6_U4_U2_U5_U1_-RIGHT__Complex_U5_U2_U6_-_U4-_U1-_r27
pathway component: HETERODIMER_ASSOCIATION_LEFT__U2AF65-_U2AF35-RIGHT__Complex__U2AF35_U2AF65_-_r23
pathway component: STATE_TRANSITION_LEFT__Complex__U2AF35_U2AF65_-_Complex__Exon_1_intron_Exon_2_-RIGHT__Complex__Exon_1_intron_Exon_2_-_r24
pathway component: STATE_TRANSITION_LEFT__Complex_U5_U2_U6_-RIGHT__Complex_Exon_2_Exon_1_-_Complex_intron_U2_U5_U6_-_r22
pathway component: HETERODIMER_ASSOCIATION_LEFT__U4-_U6-RIGHT__Complex__U6_U4_-_r10
pathway component: STATE_TRANSITION_LEFT__Complex__Exon_1_intron_Exon_2_-_U2-RIGHT__Complex__Exon_1_intron_Exon_2_-_r4
xref: PANTHER Pathway P00058 1
comment: MODEL_NOTES=Panther Pathway: P00058 Protein-coding genes contain introns which must be removed from pre-mRNAs to produce mRNAs for translation into proteins. Introns contain conserved splicing signals which ensure fidelity of splicing. Introns are removed in a large complex. The major splicing components are the U1, U2, U4/U6 and U5snRNPs (small nuclear ribonucleoprotein particles). Medline=11607023 Medline=14681577 Medline=8266100 Medline=8791582 OMIM=1411506 PMID: 11607023 PMID: 14681577 PMID: 8266100 PMID: 8791582

Protein CBR-PRP-4
type: ProteinReference
xref: PTHR19846:SF0
xref: uniprot A8XF84 40
organism: Caenorhabditis briggsae

U2AF65 s23 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF65
stoichiometric coefficient: 1.0

Complex (Exon-1/intron/Exon-2)
type: Complex
component stoichiometry: Exon 2 s12 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2 s70 a10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex U2AF35 U2AF65 s56 a97 STOICHIOMETRY ID COMPLEX
component stoichiometry: intron s11 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: U1 s69 a16 STOICHIOMETRY ID COMPLEX
component stoichiometry: Exon 1 s4 sa7 STOICHIOMETRY ID COMPLEX
component: U1
component: intron
component: Exon-2
component: Exon-1
component: Complex (U2AF35/U2AF65)
component: U2
feature: COMPLEX BINDING FEATURE s71 a7 145
feature: COMPLEX BINDING FEATURE s71 a7 153
feature: COMPLEX BINDING FEATURE s71 a7 149
feature: COMPLEX BINDING FEATURE s71 a7 151
feature: COMPLEX BINDING FEATURE s71 a7 143
feature: COMPLEX BINDING FEATURE s71 a7 147

uniprot Q9CQI7 61
type: UnificationXref
id: Q9CQI7
db: uniprot

U2AF65
type: Protein
entity reference: U2AF65
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 sa34 70
comment: SPECIES_TYPE=PROTEIN

uniprot P20053 18
type: UnificationXref
id: P20053
db: uniprot

PTHR14212:SF0
type: RelationshipXref
id: PTHR14212:SF0
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Complex_U6_U4_U2_U5_U1_-RIGHT__Complex_U5_U2_U6_-_U4-_U1-_r27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 212
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 211
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 214
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 213
left: Complex(U6/U4/U2/U5/U1)
interaction type: STATE_TRANSITION
right: Complex(U5/U2/U6)
right: U4
right: U1

uniprot O22922 57
type: UnificationXref
id: O22922
db: uniprot

intron
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa19 122
comment: SPECIES_TYPE=RNA

uniprot G2HGL9 14
type: UnificationXref
id: G2HGL9
db: uniprot

PARTICIPANT STOICHIOMETRY r27 211
type: Stoichiometry
physical entity: Complex(U6/U4/U2/U5/U1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r27 212
type: Stoichiometry
physical entity: Complex(U5/U2/U6)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r27 213
type: Stoichiometry
physical entity: U4
stoichiometric coefficient: 1.0

Exon 2 s50 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r27 214
type: Stoichiometry
physical entity: U1
stoichiometric coefficient: 1.0

U1 s68 a14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U1
stoichiometric coefficient: 1.0

uniprot F1NUK8 29
type: UnificationXref
id: F1NUK8
db: uniprot

U2AF65
type: Protein
entity reference: U2AF65
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa30 106
comment: SPECIES_TYPE=PROTEIN

U6
type: ProteinReference
xref: P01473
comment: ENTITY_REFERENCE_ID_DESC=mRNA splicing.PROTEIN.GENERIC.U6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: U6 Synonym: RNA U6 SMALL NUCLEAR,RNU6 snRNA Accession: P01473
member entity reference: Pre-mRNA-processing factor 3
member entity reference: U4/U6 small nuclear ribonucleoprotein PRP3
member entity reference: U4/U6 small nuclear ribonucleoprotein Prp3
member entity reference: Uncharacterized protein
member entity reference: Pre-mRNA processing factor 3
member entity reference: Putative U4/U6 small nuclear ribonucleoprotein
member entity reference: U4/U6 small nuclear ribonucleoprotein PRP4
member entity reference: U4/U5/U6 small nuclear ribonucleoprotein prp3
member entity reference: PRP3 pre-mRNA processing factor 3 homolog

U2AF35
type: Protein
entity reference: U2AF35
feature: COMPLEX PARTICIPANT BINDING FEATURE s88 sa25 82
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 10116 3
type: UnificationXref
id: 10116
db: ncbitaxon

U4/U6 small nuclear ribonucleoprotein PRP4
type: ProteinReference
xref: PTHR19846:SF0
xref: uniprot P20053 18
organism: Saccharomyces cerevisiae

Complex U2AF35 U2AF65 s87 a96 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (U2AF35/U2AF65)
stoichiometric coefficient: 1.0

U5 s30 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U5
stoichiometric coefficient: 1.0

U1 small nuclear ribonucleoprotein A
type: ProteinReference
xref: uniprot Q62189 66
organism: Mus musculus

uniprot Q6PE01 33
type: UnificationXref
id: Q6PE01
db: uniprot

Complex(U5/U2/U6)
type: Complex
component stoichiometry: U5 s40 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: U6 s42 sa45 STOICHIOMETRY ID COMPLEX
component stoichiometry: Exon 2 s3 a59 STOICHIOMETRY ID COMPLEX
component stoichiometry: intron s2 a60 STOICHIOMETRY ID COMPLEX
component stoichiometry: Exon 1 s1 a66 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex U2AF35 U2AF65 s87 a96 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2 s41 sa44 STOICHIOMETRY ID COMPLEX
component: U5
component: Exon-2
component: Exon-1
component: intron
component: Complex (U2AF35/U2AF65)
component: U6
component: U2
feature: COMPLEX BINDING FEATURE s91 a110 85
feature: COMPLEX BINDING FEATURE s91 a110 95
feature: COMPLEX BINDING FEATURE s91 a110 93
feature: COMPLEX BINDING FEATURE s91 a110 87
feature: COMPLEX BINDING FEATURE s91 a110 97
feature: COMPLEX BINDING FEATURE s91 a110 89
feature: COMPLEX BINDING FEATURE s91 a110 91

U6 s27 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U6
stoichiometric coefficient: 1.0

U6 s42 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U6
stoichiometric coefficient: 1.0

P01477
type: UnificationXref
id: P01477
db: PANTHER Pathway Component

P01476
type: UnificationXref
id: P01476
db: PANTHER Pathway Component

P01475
type: UnificationXref
id: P01475
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR44006:SF1
xref: uniprot F6VKV2 32
organism: Monodelphis domestica

P01474
type: UnificationXref
id: P01474
db: PANTHER Pathway Component

P01473
type: UnificationXref
id: P01473
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Complex_U5_U2_U6_-RIGHT__Complex_Exon_2_Exon_1_-_Complex_intron_U2_U5_U6_-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 207
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 205
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 206
left: Complex(U5/U2/U6)
interaction type: STATE_TRANSITION
right: Complex(Exon-2/Exon-1)
right: Complex(intron/U2/U5/U6)

U4/U6 small nuclear ribonucleoprotein Prp3
type: ProteinReference
xref: PTHR14212:SF0
xref: uniprot Q922U1 23
organism: Mus musculus

uniprot F7GH69 55
type: UnificationXref
id: F7GH69
db: uniprot

U2AF65 s86 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF65
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__U2AF65-_U2AF35-RIGHT__Complex__U2AF35_U2AF65_-_r23
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 200
left: U2AF35
left: U2AF65
interaction type: HETERODIMER_ASSOCIATION
right: Complex (U2AF35/U2AF65)

ncbitaxon 559292 19
type: UnificationXref
id: 559292
db: ncbitaxon

intron
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa8 152
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY r4 190
type: Stoichiometry
physical entity: Complex (Exon-1/intron/Exon-2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 192
type: Stoichiometry
physical entity: Complex (Exon-1/intron/Exon-2)
stoichiometric coefficient: 1.0

U2
type: ProteinReference
xref: P01478
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=mRNA splicing.PROTEIN.GENERIC.U2
comment: ENTITY_REFERENCE_NOTES= Long Name: U2 Synonym: RNU2,U2 SMALL NUCLEAR,snRNA Accession: P01478
member entity reference: U2 small nuclear ribonucleoprotein B''
member entity reference: Small nuclear ribonucleoprotein polypeptide B2
member entity reference: RCG27500, isoform CRA_c
member entity reference: SNRPB2 isoform 1
member entity reference: Uncharacterized protein
member entity reference: U2 small nuclear ribonucleoprotein B
member entity reference: U1 small nuclear ribonucleoprotein A

PARTICIPANT STOICHIOMETRY r4 191
type: Stoichiometry
physical entity: U2
stoichiometric coefficient: 1.0

U6
type: Protein
entity reference: U6
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa36 158
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r1 204
type: Stoichiometry
physical entity: Complex (Exon-1/intron/Exon-2)
stoichiometric coefficient: 1.0

Bos taurus
type: BioSource
xref: ncbitaxon 9913 9

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 13

uniprot Q96DI7 34
type: UnificationXref
id: Q96DI7
db: uniprot

PARTICIPANT STOICHIOMETRY r1 202
type: Stoichiometry
physical entity: U1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 203
type: Stoichiometry
physical entity: Complex (Exon-1/intron/Exon-2)
stoichiometric coefficient: 1.0

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 54

Exon-2
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa20 124
comment: SPECIES_TYPE=RNA

U4/U6 small nuclear ribonucleoprotein
type: ProteinReference
xref: uniprot Q1K4S2 44
organism: Neurospora crassa

Exon-2
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 a59 88
comment: SPECIES_TYPE=RNA

intron
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa5 140
comment: SPECIES_TYPE=RNA

U2 s35 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2
stoichiometric coefficient: 1.0

intron s49 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: intron
stoichiometric coefficient: 1.0

intron s2 a60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: intron
stoichiometric coefficient: 1.0

Complex U2AF35 U2AF65 s56 a97 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (U2AF35/U2AF65)
stoichiometric coefficient: 1.0

U2AF35
type: Protein
entity reference: U2AF35
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa23 112
comment: SPECIES_TYPE=PROTEIN

uniprot E2R016 27
type: UnificationXref
id: E2R016
db: uniprot

Complex(Exon-2/Exon-1)
type: Complex
component stoichiometry: Exon 2 s20 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: Exon 1 s21 sa17 STOICHIOMETRY ID COMPLEX
component: Exon-2
component: Exon-1
feature: COMPLEX BINDING FEATURE s92 a81 167
feature: COMPLEX BINDING FEATURE s92 a81 165

U2AF65
type: Protein
entity reference: U2AF65
comment: SPECIES_TYPE=PROTEIN

uniprot Q09856 21
type: UnificationXref
id: Q09856
db: uniprot

U2AF65
type: Protein
entity reference: U2AF65
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa28 110
comment: SPECIES_TYPE=PROTEIN

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 7

Small nuclear ribonucleoprotein polypeptide B2
type: ProteinReference
xref: uniprot F6YE01 53
organism: Ornithorhynchus anatinus

uniprot F2Z4C4 8
type: UnificationXref
id: F2Z4C4
db: uniprot

U6
type: Protein
entity reference: U6
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa15 80
comment: SPECIES_TYPE=PROTEIN

By Homology
type: RelationshipTypeVocabulary

Complex (U2AF35/U2AF65)
type: Complex
component stoichiometry: U2AF35 s88 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2AF65 s89 sa26 STOICHIOMETRY ID COMPLEX
component: U2AF35
component: U2AF65
feature: COMPLEX BINDING FEATURE s87 a96 81
feature: COMPLEX PARTICIPANT BINDING FEATURE s87 a96 86
feature: COMPLEX BINDING FEATURE s87 a96 83

uniprot F1MLP7 28
type: UnificationXref
id: F1MLP7
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 30

Exon 2 s20 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-2
stoichiometric coefficient: 1.0

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

U2AF65 s51 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF65
stoichiometric coefficient: 1.0

U4 s14 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U4
stoichiometric coefficient: 1.0

Complex (U4/U6/ U5)
type: Complex
component stoichiometry: U4 s26 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: U5 s30 sa37 STOICHIOMETRY ID COMPLEX
component stoichiometry: U6 s27 sa36 STOICHIOMETRY ID COMPLEX
component: U4
component: U6
component: U5
feature: COMPLEX BINDING FEATURE s34 a104 159
feature: COMPLEX BINDING FEATURE s34 a104 155
feature: COMPLEX BINDING FEATURE s34 a104 157

U1
type: Protein
entity reference: U1
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION
type: RelationshipTypeVocabulary

ZRSR2 isoform 1
type: ProteinReference
xref: uniprot H2R2N6 37
organism: Pan troglodytes

Putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
type: ProteinReference
xref: uniprot Q15695 38
organism: Homo sapiens

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
type: ProteinReference
xref: uniprot Q15696 39
organism: Homo sapiens

U4
type: ProteinReference
xref: P01476
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: U4 Synonym: AT-AC FORM,SMALL NUCLEAR RNA U4,U4ATAC Accession: P01476
comment: ENTITY_REFERENCE_ID_DESC=mRNA splicing.PROTEIN.GENERIC.U4
member entity reference: U4/U6 small nuclear ribonucleoprotein Prp3
member entity reference: U4/U6 small nuclear ribonucleoprotein PRP3
member entity reference: Uncharacterized protein
member entity reference: Pre-mRNA processing factor 3
member entity reference: Pre-mRNA-processing factor 19
member entity reference: PRP3 pre-mRNA processing factor 3 homolog
member entity reference: U4/U5/U6 small nuclear ribonucleoprotein prp3
member entity reference: Pre-mRNA-processing factor 3
member entity reference: Protein CBR-PRP-4
member entity reference: Yeast PRP (Splicing factor) related
member entity reference: U4/U6 small nuclear ribonucleoprotein PRP4
member entity reference: U4/U6 small nuclear ribonucleoprotein

ncbitaxon 9544 13
type: UnificationXref
id: 9544
db: ncbitaxon

U2AF35
type: Protein
entity reference: U2AF35
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa29 104
comment: SPECIES_TYPE=PROTEIN

uniprot Q39244 64
type: UnificationXref
id: Q39244
db: uniprot

U2AF35 s22 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF35
stoichiometric coefficient: 1.0

intron s62 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: intron
stoichiometric coefficient: 1.0

U5
type: Protein
entity reference: U5
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa37 160
comment: SPECIES_TYPE=PROTEIN

U5
type: ProteinReference
xref: P01474
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: U5 Synonym: KIAA0031,U5 snRNP-SPECIFIC PROTEIN Accession: P01474
comment: ENTITY_REFERENCE_ID_DESC=mRNA splicing.PROTEIN.GENERIC.U5
member entity reference: U5 small nuclear ribonucleoprotein 40 kDa protein
member entity reference: Uncharacterized protein
member entity reference: Small nuclear ribonucleoprotein U5 subunit 40

ncbitaxon 6238 41
type: UnificationXref
id: 6238
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot G5E5Y0 56
organism: Bos taurus

Exon-2
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 a57 176
comment: SPECIES_TYPE=RNA

U6 s13 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U6
stoichiometric coefficient: 1.0

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 41

U2 small nuclear ribonucleoprotein B''
type: ProteinReference
xref: uniprot O22922 57
organism: Arabidopsis thaliana

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 47

uniprot F7GUG7 12
type: UnificationXref
id: F7GUG7
db: uniprot

uniprot Q03338 20
type: UnificationXref
id: Q03338
db: uniprot

U2AF35
type: Protein
entity reference: U2AF35
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa33 68
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7227 60
type: UnificationXref
id: 7227
db: ncbitaxon

U5
type: Protein
entity reference: U5
comment: SPECIES_TYPE=PROTEIN

P01479
type: UnificationXref
id: P01479
db: PANTHER Pathway Component

P01478
type: UnificationXref
id: P01478
db: PANTHER Pathway Component

U5 s36 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U5
stoichiometric coefficient: 1.0

U1 small nuclear ribonucleoprotein A
type: ProteinReference
xref: uniprot Q39244 64
organism: Arabidopsis thaliana

U2AF35 s65 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF35
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 188
type: Stoichiometry
physical entity: Complex (U4/U6/ U5)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 187
type: Stoichiometry
physical entity: Complex (Exon-1/intron/Exon-2)
stoichiometric coefficient: 1.0

U2
type: Protein
entity reference: U2
comment: SPECIES_TYPE=PROTEIN

Exon 2 s80 a57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-2
stoichiometric coefficient: 1.0

Complex (Exon-1/intron/Exon-2)
type: Complex
component stoichiometry: Exon 1 s61 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex U2AF35 U2AF65 s60 a95 STOICHIOMETRY ID COMPLEX
component stoichiometry: intron s62 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Exon 2 s63 sa3 STOICHIOMETRY ID COMPLEX
component: Complex (U2AF35/U2AF65)
component: Exon-2
component: intron
component: Exon-1
feature: COMPLEX BINDING FEATURE s66 a5 131
feature: COMPLEX BINDING FEATURE s66 a5 129
feature: COMPLEX BINDING FEATURE s66 a5 127
feature: COMPLEX BINDING FEATURE s66 a5 125

PARTICIPANT STOICHIOMETRY re11 189
type: Stoichiometry
physical entity: Complex(U6/U4/U2/U5/U1)
stoichiometric coefficient: 1.0

Exon 1 s61 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-1
stoichiometric coefficient: 1.0

intron s45 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: intron
stoichiometric coefficient: 1.0

U4/U5/U6 small nuclear ribonucleoprotein prp3
type: ProteinReference
xref: uniprot Q09856 21
organism: Schizosaccharomyces pombe

Exon 2 s3 a59 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-2
stoichiometric coefficient: 1.0

U2AF35 s53 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF35
stoichiometric coefficient: 1.0

U2AF35 s55 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF35
stoichiometric coefficient: 1.0

U4
type: Protein
entity reference: U4
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa11 164
comment: SPECIES_TYPE=PROTEIN

U5 small nuclear ribonucleoprotein 40 kDa protein
type: ProteinReference
xref: PTHR44006:SF1
xref: uniprot F1MLP7 28
organism: Bos taurus

Exon-1
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa1 128
comment: SPECIES_TYPE=RNA

Complex U2AF35 U2AF65 s84 a100 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (U2AF35/U2AF65)
stoichiometric coefficient: 1.0

Exon-2
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa6 142
comment: SPECIES_TYPE=RNA

U2AF35
type: Protein
entity reference: U2AF35
feature: COMPLEX PARTICIPANT BINDING FEATURE s53 sa27 108
comment: SPECIES_TYPE=PROTEIN

uniprot Q5RK33 48
type: UnificationXref
id: Q5RK33
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SV59 31
xref: PTHR44006:SF1
organism: Macaca mulatta

ncbitaxon 9031 30
type: UnificationXref
id: 9031
db: ncbitaxon

Exon-2
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa16 166
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY r22 206
type: Stoichiometry
physical entity: Complex(Exon-2/Exon-1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 205
type: Stoichiometry
physical entity: Complex(U5/U2/U6)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 207
type: Stoichiometry
physical entity: Complex(intron/U2/U5/U6)
stoichiometric coefficient: 1.0

U2
type: Protein
entity reference: U2
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa13 76
comment: SPECIES_TYPE=PROTEIN

U4/U6 small nuclear ribonucleoprotein PRP3
type: ProteinReference
xref: PTHR14212:SF0
xref: uniprot Q03338 20
organism: Saccharomyces cerevisiae

intron s75 a56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: intron
stoichiometric coefficient: 1.0

Exon-1
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa18 120
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY r10 210
type: Stoichiometry
physical entity: Complex (U6/U4)
stoichiometric coefficient: 1.0

U2AF65
type: Protein
entity reference: U2AF65
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa22 102
comment: SPECIES_TYPE=PROTEIN

Exon-1
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa7 150
comment: SPECIES_TYPE=RNA

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

Exon 2 s12 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-2
stoichiometric coefficient: 1.0

U2 small nuclear ribonucleoprotein B''
type: ProteinReference
xref: PTHR10501:SF61
xref: uniprot Q9CQI7 61
organism: Mus musculus

STATE_TRANSITION_LEFT__Complex__Exon_1_intron_Exon_2_-_U2-RIGHT__Complex__Exon_1_intron_Exon_2_-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 191
left: U2
left: Complex (Exon-1/intron/Exon-2)
interaction type: STATE_TRANSITION
right: Complex (Exon-1/intron/Exon-2)

U2AF65
type: Protein
entity reference: U2AF65
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa32 118
comment: SPECIES_TYPE=PROTEIN

U2 small nuclear ribonucleoprotein B
type: ProteinReference
xref: PTHR10501:SF61
xref: uniprot F7GH69 55
organism: Macaca mulatta

U2 s17 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2
stoichiometric coefficient: 1.0

eco ECO:0000316 35
type: UnificationXref
id: ECO:0000316
db: eco

U4
type: Protein
entity reference: U4
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa39 180
comment: SPECIES_TYPE=PROTEIN

Small nuclear ribonucleoprotein U5 subunit 40
type: ProteinReference
xref: PTHR44006:SF1
xref: uniprot E2R016 27
organism: Canis lupus familiaris

SNRPB2 isoform 1
type: ProteinReference
xref: uniprot A0A2J8MSX5 50
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r10 209
type: Stoichiometry
physical entity: U6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 208
type: Stoichiometry
physical entity: U4
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 11

U5
type: Protein
entity reference: U5
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa41 184
comment: SPECIES_TYPE=PROTEIN

U2
type: Protein
entity reference: U2
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa40 182
comment: SPECIES_TYPE=PROTEIN

uniprot B5DEQ4 51
type: UnificationXref
id: B5DEQ4
db: uniprot

Exon 2 s63 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-2
stoichiometric coefficient: 1.0

uniprot E2R4I0 6
type: UnificationXref
id: E2R4I0
db: uniprot

U5
type: Protein
entity reference: U5
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa14 78
comment: SPECIES_TYPE=PROTEIN

PTHR44006:SF1
type: RelationshipXref
id: PTHR44006:SF1
db: PANTHER Family
relationship type: By Homology

Complex (U6/U4)
type: Complex
component stoichiometry: U4 s14 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: U6 s13 sa10 STOICHIOMETRY ID COMPLEX
component: U6
component: U4
feature: COMPLEX BINDING FEATURE s16 a29 163
feature: COMPLEX BINDING FEATURE s16 a29 161

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 22

Exon 1 s44 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 199
type: Stoichiometry
physical entity: U2AF65
stoichiometric coefficient: 1.0

uniprot Q64707 49
type: UnificationXref
id: Q64707
db: uniprot

U2AF35 s85 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2AF35
stoichiometric coefficient: 1.0

uniprot Q922U1 23
type: UnificationXref
id: Q922U1
db: uniprot

U4 s33 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U4
stoichiometric coefficient: 1.0

Yeast PRP (Splicing factor) related
type: ProteinReference
xref: uniprot Q93339 46
xref: PTHR19846:SF0
organism: Caenorhabditis elegans

ncbitaxon 367110 45
type: UnificationXref
id: 367110
db: ncbitaxon

Exon 1 s48 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-1
stoichiometric coefficient: 1.0

U2AF35
type: Protein
entity reference: U2AF35
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa31 116
comment: SPECIES_TYPE=PROTEIN

intron
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa12 74
comment: SPECIES_TYPE=RNA

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 17

uniprot H2QRB8 36
type: UnificationXref
id: H2QRB8
db: uniprot

uniprot F6VKV2 32
type: UnificationXref
id: F6VKV2
db: uniprot

intron s11 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: intron
stoichiometric coefficient: 1.0

U2 small nuclear ribonucleoprotein B''
type: ProteinReference
xref: uniprot P08579 58
organism: Homo sapiens

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 26

Uncharacterized protein
type: ProteinReference
xref: PTHR10501:SF61
xref: uniprot R4GH36 62
organism: Gallus gallus

PTHR10501:SF61
type: RelationshipXref
id: PTHR10501:SF61
db: PANTHER Family
relationship type: By Homology

uniprot F7ADZ9 10
type: UnificationXref
id: F7ADZ9
db: uniprot

uniprot A0A0G2JTI7 2
type: UnificationXref
id: A0A0G2JTI7
db: uniprot

PTHR19846:SF0
type: RelationshipXref
id: PTHR19846:SF0
db: PANTHER Family
relationship type: By Homology

intron
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s75 a56 174
comment: SPECIES_TYPE=RNA

Complex (U2AF35/U2AF65)
type: Complex
component stoichiometry: U2AF35 s22 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2AF65 s23 sa22 STOICHIOMETRY ID COMPLEX
component: U2AF65
component: U2AF35
feature: COMPLEX BINDING FEATURE s32 a94 101
feature: COMPLEX BINDING FEATURE s32 a94 99

Complex (U2AF35/U2AF65)
type: Complex
component stoichiometry: U2AF35 s85 sa33 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2AF65 s86 sa34 STOICHIOMETRY ID COMPLEX
component: U2AF35
component: U2AF65
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 a100 72
feature: COMPLEX BINDING FEATURE s84 a100 67
feature: COMPLEX BINDING FEATURE s84 a100 69

uniprot Q15695 38
type: UnificationXref
id: Q15695
db: uniprot

Exon-1
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa4 138
comment: SPECIES_TYPE=RNA

uniprot A8XF84 40
type: UnificationXref
id: A8XF84
db: uniprot

Exon-1
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 a55 172
comment: SPECIES_TYPE=RNA

Small nuclear ribonucleoprotein polypeptide A
type: ProteinReference
xref: uniprot Q5U214 65
organism: Rattus norvegicus

ncbitaxon 9913 9
type: UnificationXref
id: 9913
db: ncbitaxon

U2
type: Protein
entity reference: U2
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 a10 146
comment: SPECIES_TYPE=PROTEIN

U2AF35
type: Protein
entity reference: U2AF35
comment: SPECIES_TYPE=PROTEIN

U2AF65
type: Protein
entity reference: U2AF65
feature: COMPLEX PARTICIPANT BINDING FEATURE s89 sa26 84
comment: SPECIES_TYPE=PROTEIN

U1
type: Protein
entity reference: U1
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 a16 148
comment: SPECIES_TYPE=PROTEIN

U5 s18 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U5
stoichiometric coefficient: 1.0

uniprot H2R2N6 37
type: UnificationXref
id: H2R2N6
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

ncbitaxon 13616 11
type: UnificationXref
id: 13616
db: ncbitaxon

Complex(intron/U2/U5/U6)
type: Complex
component stoichiometry: Complex U2AF35 U2AF65 s84 a100 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2 s17 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: U5 s18 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: intron s15 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: U6 s19 sa15 STOICHIOMETRY ID COMPLEX
component: Complex (U2AF35/U2AF65)
component: U5
component: U6
component: U2
component: intron
feature: COMPLEX BINDING FEATURE s93 a80 79
feature: COMPLEX BINDING FEATURE s93 a80 73
feature: COMPLEX BINDING FEATURE s93 a80 71
feature: COMPLEX BINDING FEATURE s93 a80 77
feature: COMPLEX BINDING FEATURE s93 a80 75

intron s15 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: intron
stoichiometric coefficient: 1.0

U6
type: Protein
entity reference: U6
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa38 178
comment: SPECIES_TYPE=PROTEIN

Pre-mRNA-processing factor 3
type: ProteinReference
xref: PTHR14212:SF0
xref: uniprot A0A0G2JTI7 2
organism: Rattus norvegicus

ncbitaxon 6239 47
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot O14011 42
type: UnificationXref
id: O14011
db: uniprot

U4
type: Protein
entity reference: U4
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa35 156
comment: SPECIES_TYPE=PROTEIN

U1 small nuclear ribonucleoprotein A
type: ProteinReference
xref: uniprot P09012 63
organism: Homo sapiens

uniprot R4GH36 62
type: UnificationXref
id: R4GH36
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR14212:SF0
xref: uniprot F7ADZ9 10
organism: Monodelphis domestica

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 3

Uncharacterized protein
type: ProteinReference
xref: uniprot E2R2A8 52
organism: Canis lupus familiaris

U2AF35
type: Protein
entity reference: U2AF35
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa21 100
comment: SPECIES_TYPE=PROTEIN

Exon-2
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa3 132
comment: SPECIES_TYPE=RNA

U2AF65
type: Protein
entity reference: U2AF65
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa24 114
comment: SPECIES_TYPE=PROTEIN

uniprot E2R2A8 52
type: UnificationXref
id: E2R2A8
db: uniprot

U6 s19 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U6
stoichiometric coefficient: 1.0

U6
type: Protein
entity reference: U6
comment: SPECIES_TYPE=PROTEIN

Exon 1 s77 a55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-1
stoichiometric coefficient: 1.0

uniprot O43395 16
type: UnificationXref
id: O43395
db: uniprot

U1
type: Protein
entity reference: U1
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa42 186
comment: SPECIES_TYPE=PROTEIN

Complex (U2AF35/U2AF65)
type: Complex
component stoichiometry: U2AF65 s57 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2AF35 s53 sa27 STOICHIOMETRY ID COMPLEX
component: U2AF65
component: U2AF35
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 a97 144
feature: COMPLEX BINDING FEATURE s56 a97 109
feature: COMPLEX BINDING FEATURE s56 a97 107

Complex(U6/U4/U2/U5/U1)
type: Complex
component stoichiometry: U6 s31 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex U2AF35 U2AF65 s72 a99 STOICHIOMETRY ID COMPLEX
component stoichiometry: U1 s38 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2 s35 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: U5 s36 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: U4 s33 sa39 STOICHIOMETRY ID COMPLEX
component stoichiometry: intron s75 a56 STOICHIOMETRY ID COMPLEX
component stoichiometry: Exon 1 s77 a55 STOICHIOMETRY ID COMPLEX
component stoichiometry: Exon 2 s80 a57 STOICHIOMETRY ID COMPLEX
component: U5
component: U6
component: Complex (U2AF35/U2AF65)
component: U1
component: U2
component: intron
component: U4
component: Exon-1
component: Exon-2
feature: COMPLEX BINDING FEATURE s79 a108 179
feature: COMPLEX BINDING FEATURE s79 a108 169
feature: COMPLEX BINDING FEATURE s79 a108 183
feature: COMPLEX BINDING FEATURE s79 a108 171
feature: COMPLEX BINDING FEATURE s79 a108 173
feature: COMPLEX BINDING FEATURE s79 a108 185
feature: COMPLEX BINDING FEATURE s79 a108 181
feature: COMPLEX BINDING FEATURE s79 a108 177
feature: COMPLEX BINDING FEATURE s79 a108 175

U1 s69 a16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U1
stoichiometric coefficient: 1.0

U1
type: Protein
entity reference: U1
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 a14 136
comment: SPECIES_TYPE=PROTEIN

Putative U4/U6 small nuclear ribonucleoprotein
type: ProteinReference
xref: uniprot Q9SIB8 25
organism: Arabidopsis thaliana

STATE_TRANSITION_LEFT__U1-_Complex__Exon_1_intron_Exon_2_-RIGHT__Complex__Exon_1_intron_Exon_2_-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 204
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 202
left: Complex (Exon-1/intron/Exon-2)
left: U1
interaction type: STATE_TRANSITION
right: Complex (Exon-1/intron/Exon-2)

U4/U6 small nuclear ribonucleoprotein Prp3
type: ProteinReference
xref: PTHR14212:SF0
xref: uniprot F2Z4C4 8
organism: Bos taurus

STATE_TRANSITION
type: InteractionVocabulary

HETERODIMER_ASSOCIATION_LEFT__U4-_U6-RIGHT__Complex__U6_U4_-_r10
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 208
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 209
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 210
left: U6
left: U4
interaction type: HETERODIMER_ASSOCIATION
right: Complex (U6/U4)

Uncharacterized protein
type: ProteinReference
xref: PTHR14212:SF0
xref: uniprot F7GUG7 12
organism: Macaca mulatta

U1 s38 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U1
stoichiometric coefficient: 1.0

Exon 1 s1 a66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-1
stoichiometric coefficient: 1.0

Pre-mRNA processing factor 3
type: ProteinReference
xref: PTHR14212:SF0
xref: uniprot E2R4I0 6
organism: Canis lupus familiaris

uniprot Q9SIB8 25
type: UnificationXref
id: Q9SIB8
db: uniprot

U2 s70 a10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2
stoichiometric coefficient: 1.0

U4/U6 small nuclear ribonucleoprotein Prp3
type: ProteinReference
xref: PTHR14212:SF0
xref: uniprot O43395 16
organism: Homo sapiens

Exon 2 s46 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-2
stoichiometric coefficient: 1.0

U2 s41 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: U2
stoichiometric coefficient: 1.0

U5
type: Protein
entity reference: U5
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa43 94
comment: SPECIES_TYPE=PROTEIN

U5 small nuclear ribonucleoprotein 40 kDa protein
type: ProteinReference
xref: uniprot Q96DI7 34
xref: PTHR44006:SF1
organism: Homo sapiens

Exon 1 s21 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-1
stoichiometric coefficient: 1.0

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 35

HETERODIMER_ASSOCIATION_LEFT__Complex__U6_U4_-_U5-RIGHT__Complex__U4_U6__U5_-_r25
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 193
left: Complex (U6/U4)
left: U5
interaction type: HETERODIMER_ASSOCIATION
right: Complex (U4/U6/ U5)

ncbitaxon 284812 22
type: UnificationXref
id: 284812
db: ncbitaxon

IDA
type: EvidenceCodeVocabulary

intron
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa2 130
comment: SPECIES_TYPE=RNA

U6
type: Protein
entity reference: U6
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa10 162
comment: SPECIES_TYPE=PROTEIN

Complex U2AF35 U2AF65 s60 a95 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (U2AF35/U2AF65)
stoichiometric coefficient: 1.0

uniprot P08579 58
type: UnificationXref
id: P08579
db: uniprot

uniprot Q1K4S2 44
type: UnificationXref
id: Q1K4S2
db: uniprot

Complex (U2AF35/U2AF65)
type: Complex
component stoichiometry: U2AF65 s51 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: U2AF35 s55 sa29 STOICHIOMETRY ID COMPLEX
component: U2AF35
component: U2AF65
feature: COMPLEX BINDING FEATURE s54 a98 105
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 a98 134
feature: COMPLEX BINDING FEATURE s54 a98 103

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r25 193
type: Stoichiometry
physical entity: Complex (U6/U4)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 195
type: Stoichiometry
physical entity: Complex (U4/U6/ U5)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 194
type: Stoichiometry
physical entity: U5
stoichiometric coefficient: 1.0

ZRSR1 isoform 1
type: ProteinReference
xref: uniprot H2QRB8 36
organism: Pan troglodytes

Exon-2
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa9 154
comment: SPECIES_TYPE=RNA

Exon 1 s4 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Exon-1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Complex__U2AF35_U2AF65_-_Complex__Exon_1_intron_Exon_2_-RIGHT__Complex__Exon_1_intron_Exon_2_-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 196
left: Complex (Exon-1/intron/Exon-2)
left: Complex (U2AF35/U2AF65)
interaction type: STATE_TRANSITION
right: Complex (Exon-1/intron/Exon-2)