Cyclic AMP-dependent transcription factor ATF-1
type: ProteinReference
xref: PTHR45879:SF2
xref: uniprot Q08DA8 53
organism: Bos taurus

uniprot P24522 221
type: UnificationXref
id: P24522
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPKAP_K2-RIGHT__MAPKAP_K2-_re45
controller: p38alpha

TAB2 isoform 1
type: ProteinReference
xref: uniprot H2QTW1 164
organism: Pan troglodytes

MNK2
type: Protein
entity reference: MNK2
feature: ACTIVE 13
feature: MNK2 s67 sa83 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

MKK6
type: ProteinReference
xref: P06032
standard name: mitogen-activated protein kinase kinase 6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MKK6
comment: ENTITY_REFERENCE_NOTES= Long Name: mitogen-activated protein kinase kinase 6 Synonym: MAP2K6,MAPK/ERK kinase 6,MAPKK6,MEK6 Accession: P06032
member entity reference: Mitogen-activated protein kinase kinase 6
member entity reference: Dual specificity mitogen-activated protein kinase kinase 6
member entity reference: Uncharacterized protein

MAPKAP-K2
type: Protein
entity reference: MAPKAP-K2
feature: MAPKAP K2 s90 sa97 rs1
feature: ACTIVE 13
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re39 320
type: Stoichiometry
physical entity: MNK1
stoichiometric coefficient: 1.0

uniprot F6SSE6 219
type: UnificationXref
id: F6SSE6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38gamma-RIGHT__p38gamma-_re30
controller: MKK6

Myocyte-specific enhancer factor 2D
type: ProteinReference
xref: uniprot Q14814 99
organism: Homo sapiens

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

TAB2
type: ProteinReference
xref: P06033
standard name: TAK1 binding protein 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.TAB2
comment: ENTITY_REFERENCE_NOTES= Long Name: TAK1 binding protein 2 Synonym: MAP3K7IP2,mitogen-activated protein kinase kinase kinase 7-interacting protein 2 Accession: P06033
member entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
member entity reference: Uncharacterized protein
member entity reference: TAB2 isoform 1
member entity reference: TGF-beta activated kinase 1 (MAP3K7) binding protein 2

CREB
type: Protein
entity reference: CREB
feature: CREB s101 sa106 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MKK3
type: Protein
entity reference: MKK3
feature: MKK3 s46 sa59 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: uniprot E2RIJ6 72
xref: PTHR45992:SF3
organism: Canis lupus familiaris

uniprot F6TXC2 55
type: UnificationXref
id: F6TXC2
db: uniprot

PARTICIPANT STOICHIOMETRY re39 319
type: Stoichiometry
physical entity: MNK1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MEF-RIGHT__MEF-_re42
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 286
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 285
left: MEF
interaction type: STATE_TRANSITION
right: MEF

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot H2QS06 244
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QY25 105
organism: Macaca mulatta

Myocyte-specific enhancer factor 2B
type: ProteinReference
xref: uniprot Q02080 97
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR10411:SF3
xref: uniprot F6SSE6 219
organism: Monodelphis domestica

Mus musculus
type: BioSource
xref: ncbitaxon 10090 12

uniprot Q0V7N6 128
type: UnificationXref
id: Q0V7N6
db: uniprot

STATE_TRANSITION_LEFT__MLK2-RIGHT__MLK2-_re29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 291
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 292
left: MLK2
interaction type: STATE_TRANSITION
right: MLK2

STATE_TRANSITION_LEFT__TAK1-RIGHT__TAK1-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 307
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 308
left: TAK1
interaction type: STATE_TRANSITION
right: TAK1

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot F7C798 135
organism: Macaca mulatta

MEF
type: Protein
entity reference: MEF
feature: MEF s76 sa90 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot Q16644 226
organism: Homo sapiens

uniprot O89038 94
type: UnificationXref
id: O89038
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ELK-RIGHT__ELK-_re43
controller: p38alpha

BLOC-1-related complex subunit 8
type: ProteinReference
xref: uniprot Q9D6Y4 104
organism: Mus musculus

Interleukin 1 receptor type 1
type: ProteinReference
xref: uniprot H2QIG4 140
organism: Pan troglodytes

MAPKAP-K3
type: Protein
entity reference: MAPKAP-K3
feature: MAPKAP K3 s86 sa88 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P47811 148
type: UnificationXref
id: P47811
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CHOP10-RIGHT__CHOP10-_re40
controller: p38beta

ATF1
type: ProteinReference
xref: P06019
standard name: activating transcription factor 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: activating transcription factor 1 Synonym: cAMP-dependent transcription factor 1 Accession: P06019
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.ATF1
member entity reference: Cyclic AMP-dependent transcription factor ATF-1
member entity reference: ATF1 isoform 2
member entity reference: Activating transcription factor 1

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

eEF2K
type: ProteinReference
xref: P06022
standard name: elongation factor-2 kinase
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.eEF2K
comment: ENTITY_REFERENCE_NOTES= Long Name: elongation factor-2 kinase Synonym: calmodulin-dependent protein kinase III Accession: P06022
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Eukaryotic elongation factor 2 kinase

uniprot P18846 51
type: UnificationXref
id: P18846
db: uniprot

TNF receptor-associated factor 6
type: ProteinReference
xref: uniprot B5DF45 190
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re25 300
type: Stoichiometry
physical entity: MKK6
stoichiometric coefficient: 1.0

PTHR10159:SF299
type: RelationshipXref
id: PTHR10159:SF299
db: PANTHER Family
relationship type: By Homology

MNK2 s67 sa82 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.22
comment: MODIFICATION_RESIDUE_NAME=

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot A4GTP4 4
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__MSK1-RIGHT__MSK1-_re47
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 277
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 278
left: MSK1
interaction type: STATE_TRANSITION
right: MSK1

p38delta
type: ProteinReference
xref: P06020
standard name: p38-delta mitogen-activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.p38delta
comment: ENTITY_REFERENCE_NOTES= Long Name: p38-delta mitogen-activated protein kinase Synonym: MAPK13,SAPK4,mitogen-activated protein kinase 13,stress-activated protein kinase 4 Accession: P06020
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase

PTHR13832:SF533
type: RelationshipXref
id: PTHR13832:SF533
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O42376 21
organism: Danio rerio

IL-1R
type: ProteinReference
xref: P06030
standard name: interleukin-1 receptor
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.RECEPTOR.IL_minus_1R
comment: ENTITY_REFERENCE_NOTES= Long Name: interleukin-1 receptor Synonym: Synonym not specified Accession: P06030
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Interleukin-1 receptor type 1
member entity reference: Uncharacterized protein
member entity reference: Interleukin 1 receptor type 1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
type: ProteinReference
xref: uniprot Q15750 179
xref: PTHR13832:SF533
organism: Homo sapiens

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 29

PARTICIPANT STOICHIOMETRY re47 278
type: Stoichiometry
physical entity: MSK1
stoichiometric coefficient: 1.0

MAPKAPK2 isoform 1
type: ProteinReference
xref: uniprot H2Q104 232
xref: PTHR24349:SF63
organism: Pan troglodytes

uniprot D4A3U7 134
type: UnificationXref
id: D4A3U7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1B7Z0 161
organism: Bos taurus

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q15759 137
organism: Homo sapiens

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot F1MQE1 196
organism: Bos taurus

Ribosomal protein S6 kinase alpha-5
type: ProteinReference
xref: PTHR24351:SF115
xref: uniprot Q5F3L1 206
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPKAP_K3-RIGHT__MAPKAP_K3-_re41
controller: p38beta

PARTICIPANT STOICHIOMETRY re47 277
type: Stoichiometry
physical entity: MSK1
stoichiometric coefficient: 1.0

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot P41969 11
xref: PTHR11849:SF178
organism: Mus musculus

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: PTHR24349:SF114
xref: uniprot Q4G050 43
organism: Rattus norvegicus

Rac family small GTPase 3a
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot Q6DGB7 68
organism: Danio rerio

MAPKAP-K2
type: ProteinReference
xref: P05920
standard name: MAPK-activated protein kinase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: MAPK-activated protein kinase 2 Synonym: MK2,mitogen activated protein kinase-activated protein kinase 2 Accession: P05920
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MAPKAP_minus_K2
member entity reference: MAP kinase-activated protein kinase 2
member entity reference: MAPKAPK2 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase-activated protein kinase 2

uniprot F6WS85 88
type: UnificationXref
id: F6WS85
db: uniprot

STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_re52
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re52 310
participant stoichiometry: PARTICIPANT STOICHIOMETRY re52 309
left: HSP27
interaction type: STATE_TRANSITION
right: HSP27

MKK3 s46 sa59 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.29
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q14814 99
type: UnificationXref
id: Q14814
db: uniprot

uniprot A0A2I3TJP1 70
type: UnificationXref
id: A0A2I3TJP1
db: uniprot

MSK1
type: Protein
entity reference: MSK1
feature: MSK1 s94 sa100 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase
type: ProteinReference
xref: PTHR44329:SF39
xref: uniprot H2QGC0 131
organism: Pan troglodytes

uniprot Q06413 98
type: UnificationXref
id: Q06413
db: uniprot

uniprot O08648 124
type: UnificationXref
id: O08648
db: uniprot

uniprot K7BI90 198
type: UnificationXref
id: K7BI90
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot O15264 56
xref: PTHR24055:SF107
organism: Homo sapiens

uniprot A0A1D5Q3X8 202
type: UnificationXref
id: A0A1D5Q3X8
db: uniprot

ncbitaxon 6239 76
type: UnificationXref
id: 6239
db: ncbitaxon

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q95NE7 151
organism: Pan troglodytes

uniprot A0A3Q1NNL3 84
type: UnificationXref
id: A0A3Q1NNL3
db: uniprot

ELK
type: ProteinReference
xref: P06013
standard name: ELK-1 member of EST oncogene family
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: ELK-1 member of EST oncogene family Synonym: Synonym not specified Accession: P06013
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.ELK
member entity reference: ETS domain-containing protein Elk-1

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot A0A3Q1M614 230
xref: PTHR24349:SF63
organism: Bos taurus

eco ECO:0000245 10
type: UnificationXref
id: ECO:0000245
db: eco

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK4-RIGHT__MEKK4-_re28
controller: GADD45

uniprot F7FXI4 92
type: UnificationXref
id: F7FXI4
db: uniprot

uniprot H2Q5X1 50
type: UnificationXref
id: H2Q5X1
db: uniprot

p38delta s60 sa75 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.55
comment: MODIFICATION_RESIDUE_NAME=

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: PTHR24349:SF254
xref: uniprot Q9HBH9 39
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11945:SF145
xref: uniprot A0A1D5RIU2 80
organism: Macaca mulatta

uniprot F6ZT05 108
type: UnificationXref
id: F6ZT05
db: uniprot

STATE_TRANSITION_LEFT__MKK6-RIGHT__MKK6-_re25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 299
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 300
left: MKK6
interaction type: STATE_TRANSITION
right: MKK6

SRF
type: ProteinReference
xref: P06025
standard name: serum response factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.SRF
comment: ENTITY_REFERENCE_NOTES= Long Name: serum response factor Synonym: c-fos serum response element-binding factor Accession: P06025
member entity reference: Uncharacterized protein
member entity reference: SRF isoform 1
member entity reference: Serum response factor

MNK2
type: ProteinReference
xref: P06017
standard name: Mitogen-activated protein kinase-interacting kinase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Mitogen-activated protein kinase-interacting kinase 2 Synonym: G-protein coupled receptor kinase 7,GPRK7,MAPK-interacting kinase 2,MKNK2 Accession: P06017
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MNK2
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 2
member entity reference: MAP kinase interacting serine/threonine kinase 2

CREB s101 sa106 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

MAPKAPK3 isoform 1
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot H2QMP5 225
organism: Pan troglodytes

uniprot A0A3Q1LTT9 144
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

ATF1 s107 sa109 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot O35099 216
type: UnificationXref
id: O35099
db: uniprot

ncbitaxon 7955 22
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot H2Q3F3 192
type: UnificationXref
id: H2Q3F3
db: uniprot

PARTICIPANT STOICHIOMETRY re36 256
type: Stoichiometry
physical entity: p38alpha
stoichiometric coefficient: 1.0

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot F1MI99 243
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re36 257
type: Stoichiometry
physical entity: p38alpha
stoichiometric coefficient: 1.0

TRAF6
type: ProteinReference
xref: P06038
standard name: tumor necrosis factor receptor associated factor 6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.TRAF6
comment: ENTITY_REFERENCE_NOTES= Long Name: tumor necrosis factor receptor associated factor 6 Synonym: Synonym not specified Accession: P06038
member entity reference: TNF receptor-associated factor 6
member entity reference: TNF receptor-associated factor

uniprot O75676 199
type: UnificationXref
id: O75676
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MNK2-RIGHT__MNK2-_re38
controller: p38alpha

MEF2C isoform 4
type: ProteinReference
xref: uniprot A0A2I3TMM0 83
xref: PTHR11945:SF145
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
evidence: Evidence 41
xref: uniprot F6TJU6 40
xref: PTHR24349:SF114
organism: Macaca mulatta

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot Q62073 189
organism: Mus musculus

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 19

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MSK2-RIGHT__MSK2-_re46
controller: p38alpha

uniprot G3X793 136
type: UnificationXref
id: G3X793
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot P70236 158
type: UnificationXref
id: P70236
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__IL_1R-_TRAF6-RIGHT__IL_6R_TRAF6_complex-_re19
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 270
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 272
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 271
left: IL-1R
left: TRAF6
interaction type: HETERODIMER_ASSOCIATION
right: IL-6R/TRAF6 complex

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot Q9JM73 119
organism: Mus musculus

Myocyte enhancer factor 2C
type: ProteinReference
xref: uniprot F1PAY8 86
xref: PTHR11945:SF25
organism: Canis lupus familiaris

PTHR46716:SF1
type: RelationshipXref
id: PTHR46716:SF1
db: PANTHER Family
relationship type: By Homology

MSK2
type: ProteinReference
xref: P06039
standard name: mitogen- and stress-activated protein kinase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MSK2
comment: ENTITY_REFERENCE_NOTES= Long Name: mitogen- and stress-activated protein kinase 2 Synonym: 90 kDa ribosomal protein S6 kinase 4,RSKB,ribosomal protein kinase B Accession: P06039
member entity reference: Ribosomal protein S6 kinase
member entity reference: Ribosomal protein S6 kinase alpha-4

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK6-RIGHT__MKK6-_re25
controller: TAK1

cAMP response element-binding protein
type: ProteinReference
xref: PTHR45879:SF1
xref: uniprot Q7SX83 129
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY re42 285
type: Stoichiometry
physical entity: MEF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re34 260
type: Stoichiometry
physical entity: p38delta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re34 261
type: Stoichiometry
physical entity: p38delta
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R1Y7 79
xref: PTHR11945:SF637
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re27 295
type: Stoichiometry
physical entity: MKK4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re42 286
type: Stoichiometry
physical entity: MEF
stoichiometric coefficient: 1.0

CREB
type: Protein
entity reference: CREB
feature: ACTIVE 13
feature: CREB s104 sa107 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot E2R9L4 122
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re27 296
type: Stoichiometry
physical entity: MKK4
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot F7G4D2 116
organism: Macaca mulatta

uniprot F7H1J8 93
type: UnificationXref
id: F7H1J8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MSK2-RIGHT__MSK2-_re46
controller: p38beta

uniprot F7FP88 115
type: UnificationXref
id: F7FP88
db: uniprot

Ribosomal protein S6 kinase alpha-5
type: ProteinReference
xref: uniprot Q8C050 207
xref: PTHR24351:SF115
organism: Mus musculus

Cell division control protein 42 homolog isoform 2
type: ProteinReference
xref: PTHR24072:SF337
xref: uniprot F6RBZ7 210
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPKAP_K2-RIGHT__MAPKAP_K2-_re45
controller: p38beta

CHOP10
type: Protein
feature: CHOP10 s70 sa86 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot P11831 118
organism: Homo sapiens

GADD45
type: Protein
entity reference: GADD45
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE1 152
organism: Danio rerio

Myocyte-specific enhancer factor 2D
type: ProteinReference
xref: uniprot F6VKY1 87
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6YAB9 146
xref: PTHR24055:SF110
organism: Monodelphis domestica

MKP5
type: Protein
entity reference: MKP5
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9WTY9 59
type: UnificationXref
id: Q9WTY9
db: uniprot

uniprot P53778 23
type: UnificationXref
id: P53778
db: uniprot

uniprot P11831 118
type: UnificationXref
id: P11831
db: uniprot

TNF receptor-associated factor 6
type: ProteinReference
xref: uniprot B6CJY5 191
organism: Macaca mulatta

Cyclic AMP-dependent transcription factor ATF-1
type: ProteinReference
xref: PTHR45879:SF2
xref: uniprot P81269 52
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CREB-RIGHT__CREB-_re50
controller: MSK2

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H1J8 93
organism: Macaca mulatta

uniprot H2R902 220
type: UnificationXref
id: H2R902
db: uniprot

ncbitaxon 7739 209
type: UnificationXref
id: 7739
db: ncbitaxon

PTHR11945:SF637
type: RelationshipXref
id: PTHR11945:SF637
db: PANTHER Family
relationship type: By Homology

uniprot P04792 30
type: UnificationXref
id: P04792
db: uniprot

MKK4
type: Protein
entity reference: MKK4
feature: MKK4 s49 sa62 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7HHY8 231
type: UnificationXref
id: F7HHY8
db: uniprot

STATE_TRANSITION_LEFT__ELK-RIGHT__ELK-_re43
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 284
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 283
left: ELK
interaction type: STATE_TRANSITION
right: ELK

uniprot A9JRY8 61
type: UnificationXref
id: A9JRY8
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

PTHR44329:SF39
type: RelationshipXref
id: PTHR44329:SF39
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATF1-RIGHT__ATF1-_re51
controller: MSK1

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: uniprot P70531 78
xref: PTHR45992:SF3
organism: Rattus norvegicus

MKP1
type: Protein
entity reference: MKP1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot A0A2I3RB56 154
xref: PTHR48013:SF12
organism: Pan troglodytes

STATE_TRANSITION_LEFT__eEF2K-RIGHT__eEF2K-_re37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 255
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 254
left: eEF2K
interaction type: STATE_TRANSITION
right: eEF2K

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38delta-RIGHT__p38delta-_re31
controller: MKK6

PARTICIPANT STOICHIOMETRY re24 301
type: Stoichiometry
physical entity: p38alpha
stoichiometric coefficient: 1.0

uniprot A0A1D5QAU9 168
type: UnificationXref
id: A0A1D5QAU9
db: uniprot

PARTICIPANT STOICHIOMETRY re24 302
type: Stoichiometry
physical entity: p38alpha
stoichiometric coefficient: 1.0

MSK1
type: ProteinReference
xref: P06040
standard name: mitogen- and stress-activated protein kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MSK1
comment: ENTITY_REFERENCE_NOTES= Long Name: mitogen- and stress-activated protein kinase 1 Synonym: 90 kD ribosomal protein S6 kinase 5,RPS6KA5 Accession: P06040
member entity reference: Ribosomal protein S6 kinase
member entity reference: Ribosomal protein S6 kinase alpha-5

ncbitaxon 10090 12
type: UnificationXref
id: 10090
db: ncbitaxon

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot E1BJP4 113
organism: Bos taurus

PTHR11945:SF145
type: RelationshipXref
id: PTHR11945:SF145
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot F6ZTS0 18
organism: Macaca mulatta

uniprot F6XTF7 27
type: UnificationXref
id: F6XTF7
db: uniprot

eEF2K s65 sa80 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.97
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

CHOP10
type: Protein
feature: ACTIVE 13
feature: CHOP10 s72 sa87 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot B6CJY5 191
type: UnificationXref
id: B6CJY5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38beta-RIGHT__p38beta-_re35
controller: MKP1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MSK1-RIGHT__MSK1-_re47
controller: p38alpha

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 76

uniprot Q9NYJ8 167
type: UnificationXref
id: Q9NYJ8
db: uniprot

PARTICIPANT STOICHIOMETRY re53 306
type: Stoichiometry
physical entity: 4EBP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re53 305
type: Stoichiometry
physical entity: 4EBP1
stoichiometric coefficient: 1.0

MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)
type: ProteinReference
xref: PTHR11945:SF25
xref: uniprot F6WS85 88
organism: Xenopus tropicalis

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O08911 20
organism: Mus musculus

uniprot F1PAY8 86
type: UnificationXref
id: F1PAY8
db: uniprot

uniprot P19419 8
type: UnificationXref
id: P19419
db: uniprot

Dual specificity phosphatase 10
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot E2R7G4 236
organism: Canis lupus familiaris

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot D4A3U7 134
organism: Rattus norvegicus

MNK2
type: Protein
entity reference: MNK2
feature: MNK2 s67 sa82 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q8CF89 180
type: UnificationXref
id: Q8CF89
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot K7DH81 204
xref: PTHR24351:SF115
organism: Pan troglodytes

Rac family small GTPase 1b
type: ProteinReference
xref: uniprot Q29RC5 65
xref: PTHR24072:SF105
organism: Danio rerio

uniprot Q66H84 229
type: UnificationXref
id: Q66H84
db: uniprot

STATE_TRANSITION_LEFT__MSK2-RIGHT__MSK2-_re46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 280
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 279
left: MSK2
interaction type: STATE_TRANSITION
right: MSK2

uniprot F6U725 237
type: UnificationXref
id: F6U725
db: uniprot

uniprot F7FK48 91
type: UnificationXref
id: F7FK48
db: uniprot

uniprot P52564 157
type: UnificationXref
id: P52564
db: uniprot

PARTICIPANT STOICHIOMETRY re32 264
type: Stoichiometry
physical entity: p38beta
stoichiometric coefficient: 1.0

MSK1
type: Protein
entity reference: MSK1
feature: MSK1 s96 sa101 rs1
feature: ACTIVE 13
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re32 265
type: Stoichiometry
physical entity: p38beta
stoichiometric coefficient: 1.0

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P04792 30
xref: PTHR45640:SF7
organism: Homo sapiens

p38gamma
type: ProteinReference
xref: P06015
standard name: p38-gamma mitogen-activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: p38-gamma mitogen-activated protein kinase Synonym: ERK6,MAPK12,SAPK3,extracellular signal-regulated kinase 6,mitogen-activated protein kinase 12,stress-activated protein kinase 3 Accession: P06015
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.p38gamma
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Mitogen-activated protein kinase

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot F1PBB6 170
xref: PTHR48013:SF15
organism: Canis lupus familiaris

MKK3
type: Protein
entity reference: MKK3
feature: ACTIVE 13
feature: MKK3 s48 sa61 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

TRANSPORT
type: RelationshipTypeVocabulary

uniprot F6TJU6 40
type: UnificationXref
id: F6TJU6
db: uniprot

uniprot O42376 21
type: UnificationXref
id: O42376
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEF-RIGHT__MEF-_re42
controller: p38alpha

uniprot P45985 173
type: UnificationXref
id: P45985
db: uniprot

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 10

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38beta-RIGHT__p38beta-_re35
controller: MKP5

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPKAP_K3-RIGHT__MAPKAP_K3-_re41
controller: p38alpha

uniprot Q16644 226
type: UnificationXref
id: Q16644
db: uniprot

HSP27
type: Protein
entity reference: HSP27
feature: HSP27 s108 sa110 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4EBP1-RIGHT__4EBP1-_re53
controller: MSK1

uniprot Q925D6 160
type: UnificationXref
id: Q925D6
db: uniprot

SRF s103 sa105 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.89
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: uniprot O08605 42
xref: PTHR24349:SF114
organism: Mus musculus

TRAF6 s37 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

MKK4 s50 sa63 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.11

uniprot Q4G050 43
type: UnificationXref
id: Q4G050
db: uniprot

SRF s99 sa104 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.89
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38delta-RIGHT__p38delta-_re34
controller: MKP1

ASK1
type: ProteinReference
xref: P06043
standard name: mitogen-activated protein kinase kinase kinase 5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: mitogen-activated protein kinase kinase kinase 5 Synonym: MAP/ERK kinase kinase 5,MAPKKK5,MEKK5,apoptosis signal-regulating kinase 1 Accession: P06043
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.ASK1
member entity reference: Mitogen-activated protein kinase kinase kinase 5
member entity reference: Uncharacterized protein
member entity reference: MAP3K5 isoform 1

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 209

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FRM2 238
xref: PTHR10159:SF299
organism: Macaca mulatta

PTHR24349:SF63
type: RelationshipXref
id: PTHR24349:SF63
db: PANTHER Family
relationship type: By Homology

PTHR24349:SF64
type: RelationshipXref
id: PTHR24349:SF64
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TMM0 83
type: UnificationXref
id: A0A2I3TMM0
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF20
xref: uniprot P45985 173
organism: Homo sapiens

STATE_TRANSITION_LEFT__CHOP10-RIGHT__CHOP10-_re40
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 289
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 290
left: CHOP10
interaction type: STATE_TRANSITION
right: CHOP10

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MLK2-RIGHT__MLK2-_re29
controller: Cdc42

uniprot Q5U303 165
type: UnificationXref
id: Q5U303
db: uniprot

uniprot Q02080 97
type: UnificationXref
id: Q02080
db: uniprot

uniprot Q9Z2B9 200
type: UnificationXref
id: Q9Z2B9
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9Z1B7 60
xref: PTHR24055:SF107
organism: Mus musculus

uniprot F7BRQ2 47
type: UnificationXref
id: F7BRQ2
db: uniprot

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot Q3UMW7 228
organism: Mus musculus

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: uniprot Q3SYZ2 227
xref: PTHR24349:SF64
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot F6PR50 123
organism: Macaca mulatta

uniprot F1PBB6 170
type: UnificationXref
id: F1PBB6
db: uniprot

MAPKAP K2 s90 sa97 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

PARTICIPANT STOICHIOMETRY re41 287
type: Stoichiometry
physical entity: MAPKAP-K3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re41 288
type: Stoichiometry
physical entity: MAPKAP-K3
stoichiometric coefficient: 1.0

uniprot A0A3Q1NEI6 106
type: UnificationXref
id: A0A3Q1NEI6
db: uniprot

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: PTHR45992:SF3
xref: uniprot A0A2I3TJP1 70
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re37 254
type: Stoichiometry
physical entity: eEF2K
stoichiometric coefficient: 1.0

uniprot A0A1D5QY25 105
type: UnificationXref
id: A0A1D5QY25
db: uniprot

uniprot P63074 111
type: UnificationXref
id: P63074
db: uniprot

MNK2 s67 sa83 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.22
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re46 279
type: Stoichiometry
physical entity: MSK2
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 48

uniprot C3ZIB9 208
type: UnificationXref
id: C3ZIB9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TAB2-RIGHT__TAB2-_re20
controller: IL-6R/TRAF6 complex

uniprot A0A3Q1LJZ7 14
type: UnificationXref
id: A0A3Q1LJZ7
db: uniprot

uniprot Q15750 179
type: UnificationXref
id: Q15750
db: uniprot

uniprot E2RKA7 54
type: UnificationXref
id: E2RKA7
db: uniprot

STATE_TRANSITION_LEFT__CREB-RIGHT__CREB-_re50
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re50 317
participant stoichiometry: PARTICIPANT STOICHIOMETRY re50 318
left: CREB
interaction type: STATE_TRANSITION
right: CREB

PARTICIPANT STOICHIOMETRY re46 280
type: Stoichiometry
physical entity: MSK2
stoichiometric coefficient: 1.0

GADD45A isoform 1
type: ProteinReference
xref: uniprot H2R902 220
xref: PTHR10411:SF3
organism: Pan troglodytes

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot E2R3R6 183
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__eIF4E-RIGHT__eIF4E-_re48
controller: MNK1

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P42929 33
organism: Canis lupus familiaris

uniprot O08911 20
type: UnificationXref
id: O08911
db: uniprot

p38alpha
type: Protein
entity reference: p38alpha
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re45 282
type: Stoichiometry
physical entity: MAPKAP-K2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re45 281
type: Stoichiometry
physical entity: MAPKAP-K2
stoichiometric coefficient: 1.0

HSP27 s110 sa111 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.44
comment: MODIFICATION_RESIDUE_NAME=

ncbitaxon 9258 63
type: UnificationXref
id: 9258
db: ncbitaxon

MSK2
type: Protein
entity reference: MSK2
feature: MSK2 s91 sa98 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MNK1 s68 sa84 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.33

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot G3X793 136
organism: Bos taurus

ACTIVE 13
type: EntityFeature
comment: Active state

CREB s104 sa107 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot O08648 124
organism: Mus musculus

uniprot D3ZHH8 112
type: UnificationXref
id: D3ZHH8
db: uniprot

ncbitaxon 7227 96
type: UnificationXref
id: 7227
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RHD1 153
xref: PTHR48013:SF12
organism: Macaca mulatta

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P42930 34
organism: Rattus norvegicus

p38alpha
type: Protein
entity reference: p38alpha
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

TGF-beta activated kinase 1 (MAP3K7) binding protein 2
type: ProteinReference
xref: uniprot F6R2J2 162
organism: Monodelphis domestica

uniprot F7H6S1 185
type: UnificationXref
id: F7H6S1
db: uniprot

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

uniprot H9EP11 36
type: UnificationXref
id: H9EP11
db: uniprot

uniprot Q64623 247
type: UnificationXref
id: Q64623
db: uniprot

Cyclic AMP-dependent transcription factor ATF-1
type: ProteinReference
xref: PTHR45879:SF2
xref: uniprot P18846 51
organism: Homo sapiens

uniprot Q9ESS0 241
type: UnificationXref
id: Q9ESS0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MLK2-RIGHT__MLK2-_re29
controller: Rac

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 148
xref: PTHR24055:SF110
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MNK1-RIGHT__MNK1-_re39
controller: p38alpha

Ribosomal protein S6 kinase alpha-5
type: ProteinReference
xref: uniprot O75582 205
xref: PTHR24351:SF115
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: PTHR44305:SF4
xref: uniprot Q5E9X2 159
organism: Bos taurus

p38gamma s57 sa72 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

uniprot E2R7G4 236
type: UnificationXref
id: E2R7G4
db: uniprot

uniprot P42929 33
type: UnificationXref
id: P42929
db: uniprot

uniprot A0A2I3RB56 154
type: UnificationXref
id: A0A2I3RB56
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK4-RIGHT__MEKK4-_re28
controller: Rac

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P47809 174
xref: PTHR48013:SF15
organism: Mus musculus

uniprot Q9N272 58
type: UnificationXref
id: Q9N272
db: uniprot

uniprot Q62073 189
type: UnificationXref
id: Q62073
db: uniprot

MKK4 s49 sa62 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.11

ATF1
type: Protein
entity reference: ATF1
feature: ATF1 s105 sa108 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot F7CCD5 184
xref: PTHR46716:SF1
organism: Monodelphis domestica

uniprot H2Q104 232
type: UnificationXref
id: H2Q104
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 22

MKK3 s48 sa61 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.29
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATF1-RIGHT__ATF1-_re51
controller: MSK2

uniprot F6PR50 123
type: UnificationXref
id: F6PR50
db: uniprot

uniprot O08796 77
type: UnificationXref
id: O08796
db: uniprot

uniprot E1BN61 203
type: UnificationXref
id: E1BN61
db: uniprot

ELK
type: Protein
entity reference: ELK
feature: ELK s81 sa93 rs1
feature: ACTIVE 13
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Myocyte-specific enhancer factor 2A
type: ProteinReference
xref: PTHR48019:SF47
xref: uniprot A2VDZ3 85
organism: Bos taurus

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot Q63538 24
organism: Rattus norvegicus

uniprot F6VKY1 87
type: UnificationXref
id: F6VKY1
db: uniprot

Interleukin-1 receptor type 1
type: ProteinReference
xref: uniprot P14778 142
organism: Homo sapiens

uniprot Q9JM73 119
type: UnificationXref
id: Q9JM73
db: uniprot

PARTICIPANT STOICHIOMETRY re25 299
type: Stoichiometry
physical entity: MKK6
stoichiometric coefficient: 1.0

eIF4E
type: Protein
entity reference: eIF4E
feature: eIF4E s97 sa102 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__ATF1-RIGHT__ATF1-_re51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re51 313
participant stoichiometry: PARTICIPANT STOICHIOMETRY re51 314
left: ATF1
interaction type: STATE_TRANSITION
right: ATF1

PTHR45640:SF7
type: RelationshipXref
id: PTHR45640:SF7
db: PANTHER Family
relationship type: By Homology

p38alpha
type: Protein
entity reference: p38alpha
feature: ACTIVE 13
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot P53778 23
organism: Homo sapiens

Heat shock protein beta-1
type: ProteinReference
xref: PTHR45640:SF7
xref: uniprot F6XTF7 27
organism: Macaca mulatta

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
type: ProteinReference
xref: uniprot Q5U303 165
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CREB-RIGHT__CREB-_re50
controller: MSK1

MKK6 s47 sa60 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot D3ZHH8 112
organism: Rattus norvegicus

MEF s76 sa90 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MNK1-RIGHT__MNK1-_re39
controller: p38beta

Myocyte enhancer factor 2A
type: ProteinReference
xref: PTHR11945:SF637
xref: uniprot A0A2I3S0F9 81
organism: Pan troglodytes

TNF receptor-associated factor
type: ProteinReference
xref: uniprot H2Q3F3 192
organism: Pan troglodytes

IDA
type: EvidenceCodeVocabulary

PARTICIPANT STOICHIOMETRY re22 308
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 307
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: PTHR24349:SF254
xref: uniprot Q5U2N4 37
organism: Rattus norvegicus

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot F6PXH5 181
xref: PTHR48013:SF21
organism: Ornithorhynchus anatinus

uniprot E1BEM1 71
type: UnificationXref
id: E1BEM1
db: uniprot

uniprot A4GTP4 4
type: UnificationXref
id: A4GTP4
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot A2VDU3 182
organism: Bos taurus

uniprot F6PXH5 181
type: UnificationXref
id: F6PXH5
db: uniprot

TAB1
type: Protein
entity reference: TAB1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P06730 109
type: UnificationXref
id: P06730
db: uniprot

uniprot A0A1D5RHD1 153
type: UnificationXref
id: A0A1D5RHD1
db: uniprot

uniprot F1PH12 114
type: UnificationXref
id: F1PH12
db: uniprot

PANTHER Pathway P05918 1
type: UnificationXref
id: P05918
db: PANTHER Pathway

p38beta s61 sa76 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.4

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 5

STATE_TRANSITION_LEFT__MAPKAP_K3-RIGHT__MAPKAP_K3-_re41
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 288
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 287
left: MAPKAP-K3
interaction type: STATE_TRANSITION
right: MAPKAP-K3

PTHR10411:SF3
type: RelationshipXref
id: PTHR10411:SF3
db: PANTHER Family
relationship type: By Homology

Eukaryotic translation initiation factor 4E
type: ProteinReference
xref: uniprot P63074 111
organism: Rattus norvegicus

Eukaryotic translation initiation factor 4E
type: ProteinReference
xref: uniprot P63073 110
organism: Mus musculus

MAP2K4 isoform 3
type: ProteinReference
xref: PTHR48013:SF20
xref: uniprot H2QCA7 172
organism: Pan troglodytes

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
type: ProteinReference
xref: uniprot Q8CF89 180
xref: PTHR13832:SF533
organism: Mus musculus

HSP27
type: ProteinReference
xref: P06016
standard name: heat shock protein 27kD
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.HSP27
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: heat shock protein 27kD Synonym: HSPB1 Accession: P06016
member entity reference: Heat shock protein beta-1
member entity reference: Heat shock protein family B (small) member 1
member entity reference: HSPB1 isoform 1

PTHR44305:SF4
type: RelationshipXref
id: PTHR44305:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q99K90 166
type: UnificationXref
id: Q99K90
db: uniprot

uniprot F7FD05 127
type: UnificationXref
id: F7FD05
db: uniprot

4EBP1 s111 sa112 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.22
comment: MODIFICATION_RESIDUE_NAME=

4EBP1
type: Protein
feature: ACTIVE 13
feature: 4EBP1 s113 sa113 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase 10
type: ProteinReference
xref: PTHR44329:SF39
xref: uniprot Q02779 132
organism: Homo sapiens

By Homology
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__p38gamma-RIGHT__p38gamma-_re30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 269
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 268
left: p38gamma
interaction type: STATE_TRANSITION
right: p38gamma

STATE_TRANSITION_LEFT__p38gamma-RIGHT__p38gamma-_re33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 263
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 262
left: p38gamma
interaction type: STATE_TRANSITION
right: p38gamma

STATE_TRANSITION_LEFT__MNK1-RIGHT__MNK1-_re39
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 319
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 320
left: MNK1
interaction type: STATE_TRANSITION
right: MNK1

TAB2
type: Protein
entity reference: TAB2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7BFL2 224
type: UnificationXref
id: F7BFL2
db: uniprot

uniprot H2RCY2 186
type: UnificationXref
id: H2RCY2
db: uniprot

cAMP responsive element binding protein 1
type: ProteinReference
xref: uniprot Q0V7N6 128
xref: PTHR45879:SF1
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NNL3 84
organism: Bos taurus

MKK6
type: Protein
entity reference: MKK6
feature: MKK6 s45 sa58 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

TAK1
type: ProteinReference
xref: P06037
standard name: TGF beta-activated kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: TGF beta-activated kinase 1 Synonym: MAP3K7,mitogen-activated protein kinase kinase kinase 7 Accession: P06037
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.TAK1
member entity reference: Mitogen-activated protein kinase kinase kinase 7

uniprot Q3ZBN6 223
type: UnificationXref
id: Q3ZBN6
db: uniprot

PTHR24349:SF254
type: RelationshipXref
id: PTHR24349:SF254
db: PANTHER Family
relationship type: By Homology

uniprot H2QUT1 28
type: UnificationXref
id: H2QUT1
db: uniprot

PARTICIPANT STOICHIOMETRY re35 258
type: Stoichiometry
physical entity: p38beta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re35 259
type: Stoichiometry
physical entity: p38beta
stoichiometric coefficient: 1.0

ATF1 s105 sa108 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

p38delta
type: Protein
entity reference: p38delta
feature: ACTIVE 13
feature: p38delta s60 sa75 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q29RC5 65
type: UnificationXref
id: Q29RC5
db: uniprot

Activating transcription factor 1
type: ProteinReference
xref: PTHR45879:SF2
xref: uniprot F7BRQ2 47
organism: Monodelphis domestica

PTHR48016:SF32
type: RelationshipXref
id: PTHR48016:SF32
db: PANTHER Family
relationship type: By Homology

PTHR11945:SF25
type: RelationshipXref
id: PTHR11945:SF25
db: PANTHER Family
relationship type: By Homology

TGF-beta activated kinase 1 (MAP3K7) binding protein 1
type: ProteinReference
xref: uniprot F1PLP7 177
xref: PTHR13832:SF533
organism: Canis lupus familiaris

MAPKAP K2 s88 sa96 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot Q6DGB7 68
type: UnificationXref
id: Q6DGB7
db: uniprot

uniprot O00418 74
type: UnificationXref
id: O00418
db: uniprot

uniprot P48316 222
type: UnificationXref
id: P48316
db: uniprot

uniprot P63073 110
type: UnificationXref
id: P63073
db: uniprot

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot E2R7W7 155
xref: PTHR48013:SF12
organism: Canis lupus familiaris

MAPKAP-K2
type: Protein
entity reference: MAPKAP-K2
feature: MAPKAP K2 s88 sa96 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot I0FRT6 214
type: UnificationXref
id: I0FRT6
db: uniprot

MEF
type: ProteinReference
xref: P06023
standard name: myocyte enhancer factor 2
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MEF
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: myocyte enhancer factor 2 Synonym: Synonym not specified Accession: P06023
member entity reference: Myocyte-specific enhancer factor 2B
member entity reference: Myocyte-specific enhancer factor 2D
member entity reference: BLOC-1-related complex subunit 8
member entity reference: Myocyte-specific enhancer factor 2C
member entity reference: Myocyte-specific enhancer factor 2A
member entity reference: MEF2C isoform 4
member entity reference: Uncharacterized protein
member entity reference: MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)
member entity reference: Myocyte enhancer factor 2C
member entity reference: Myocyte enhancer factor 2A
member entity reference: Myocyte enhancer factor 2B
member entity reference: Myocyte-specific enhancer factor 2
member entity reference: MEF2D isoform 1

eIF4E
type: ProteinReference
xref: P06024
standard name: eukaryotic initiation factor 4E
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: eukaryotic initiation factor 4E Synonym: Synonym not specified Accession: P06024
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.eIF4E
member entity reference: Uncharacterized protein
member entity reference: Eukaryotic translation initiation factor 4E

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot I0FRT6 214
xref: PTHR11584:SF332
organism: Macaca mulatta

uniprot Q9BUB5 45
type: UnificationXref
id: Q9BUB5
db: uniprot

p38delta s59 sa74 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.55
comment: MODIFICATION_RESIDUE_NAME=

uniprot A2VDU3 182
type: UnificationXref
id: A2VDU3
db: uniprot

Rac family small GTPase 3b
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot A9JRY8 61
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot C3ZIB9 208
organism: Branchiostoma floridae

eIF4E s98 sa103 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.29
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Eukaryotic translation initiation factor 4E
type: ProteinReference
xref: uniprot A0A3Q1NEI6 106
organism: Bos taurus

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 3

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MXH6 213
xref: PTHR11584:SF332
organism: Bos taurus

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot O35099 216
xref: PTHR11584:SF332
organism: Mus musculus

uniprot P49137 233
type: UnificationXref
id: P49137
db: uniprot

uniprot Q7SX83 129
type: UnificationXref
id: Q7SX83
db: uniprot

uniprot P14602 32
type: UnificationXref
id: P14602
db: uniprot

uniprot O08605 42
type: UnificationXref
id: O08605
db: uniprot

uniprot Q9Y6R4 125
type: UnificationXref
id: Q9Y6R4
db: uniprot

uniprot F7FH99 62
type: UnificationXref
id: F7FH99
db: uniprot

uniprot Q90694 212
type: UnificationXref
id: Q90694
db: uniprot

p38 MAPK pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__p38delta-RIGHT__p38delta-_re34
pathway component: STATE_TRANSITION_LEFT__MKK3-RIGHT__MKK3-_re26
pathway component: STATE_TRANSITION_LEFT__4EBP1-RIGHT__4EBP1-_re53
pathway component: STATE_TRANSITION_LEFT__p38beta-RIGHT__p38beta-_re32
pathway component: STATE_TRANSITION_LEFT__MEF-RIGHT__MEF-_re42
pathway component: STATE_TRANSITION_LEFT__CHOP10-RIGHT__CHOP10-_re40
pathway component: STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_re52
pathway component: TRANSPORT_LEFT__p38alpha-RIGHT__p38alpha-_re24
pathway component: STATE_TRANSITION_LEFT__MAPKAP_K3-RIGHT__MAPKAP_K3-_re41
pathway component: STATE_TRANSITION_LEFT__p38beta-RIGHT__p38beta-_re35
pathway component: STATE_TRANSITION_LEFT__MSK2-RIGHT__MSK2-_re46
pathway component: STATE_TRANSITION_LEFT__TAB2-RIGHT__TAB2-_re20
pathway component: STATE_TRANSITION_LEFT__eEF2K-RIGHT__eEF2K-_re37
pathway component: STATE_TRANSITION_LEFT__MEKK4-RIGHT__MEKK4-_re28
pathway component: STATE_TRANSITION_LEFT__p38alpha-RIGHT__p38alpha-_re36
pathway component: STATE_TRANSITION_LEFT__p38delta-RIGHT__p38delta-_re31
pathway component: STATE_TRANSITION_LEFT__p38gamma-RIGHT__p38gamma-_re33
pathway component: STATE_TRANSITION_LEFT__eIF4E-RIGHT__eIF4E-_re48
pathway component: STATE_TRANSITION_LEFT__MNK2-RIGHT__MNK2-_re38
pathway component: STATE_TRANSITION_LEFT__MSK1-RIGHT__MSK1-_re47
pathway component: STATE_TRANSITION_LEFT__MKK4-RIGHT__MKK4-_re27
pathway component: STATE_TRANSITION_LEFT__p38alpha-RIGHT__p38alpha-_re23
pathway component: STATE_TRANSITION_LEFT__ATF1-RIGHT__ATF1-_re51
pathway component: STATE_TRANSITION_LEFT__MLK2-RIGHT__MLK2-_re29
pathway component: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_re49
pathway component: STATE_TRANSITION_LEFT__ELK-RIGHT__ELK-_re43
pathway component: HETERODIMER_ASSOCIATION_LEFT__IL_1R-_TRAF6-RIGHT__IL_6R_TRAF6_complex-_re19
pathway component: STATE_TRANSITION_LEFT__MNK1-RIGHT__MNK1-_re39
pathway component: STATE_TRANSITION_LEFT__MAPKAP_K2-RIGHT__MAPKAP_K2-_re45
pathway component: STATE_TRANSITION_LEFT__MKK6-RIGHT__MKK6-_re25
pathway component: STATE_TRANSITION_LEFT__CREB-RIGHT__CREB-_re50
pathway component: STATE_TRANSITION_LEFT__TAK1-RIGHT__TAK1-_re22
pathway component: STATE_TRANSITION_LEFT__TAB1-RIGHT__TAB1-_re21
pathway component: STATE_TRANSITION_LEFT__p38gamma-RIGHT__p38gamma-_re30
xref: PANTHER Pathway P05918 1
comment: MODEL_NOTES=Panther Pathway: P05918 p38 is a mitogen-activated protein kinase (MAPK) regulated by stress and cytokines. There are four p38 genes: a, b, g, and d. Medline=12471242 Medline=12554854 PMID: 12471242 PMID: 12554854

TAB1
type: Protein
entity reference: TAB1
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

SRF
type: Protein
entity reference: SRF
feature: ACTIVE 13
feature: SRF s103 sa105 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: uniprot E1BEM1 71
xref: PTHR45992:SF3
organism: Bos taurus

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q9WUI1 138
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot Q9Y6R4 125
organism: Homo sapiens

uniprot E2RSB0 16
type: UnificationXref
id: E2RSB0
db: uniprot

PARTICIPANT STOICHIOMETRY re29 292
type: Stoichiometry
physical entity: MLK2
stoichiometric coefficient: 1.0

MNK1
type: ProteinReference
xref: P06018
standard name: mitogen-activated protein kinase-interacting kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MNK1
comment: ENTITY_REFERENCE_NOTES= Long Name: mitogen-activated protein kinase-interacting kinase 1 Synonym: Synonym not specified Accession: P06018
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 1
member entity reference: Uncharacterized protein

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: ProteinReference
xref: PTHR10411:SF3
xref: uniprot Q3ZBN6 223
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re29 291
type: Stoichiometry
physical entity: MLK2
stoichiometric coefficient: 1.0

ncbitaxon 9606 9
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q08DA8 53
type: UnificationXref
id: Q08DA8
db: uniprot

uniprot P28563 246
type: UnificationXref
id: P28563
db: uniprot

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
type: ProteinReference
xref: uniprot F7H8X1 178
xref: PTHR13832:SF533
organism: Macaca mulatta

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 96

4EBP1
type: Protein
feature: 4EBP1 s111 sa112 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR48019:SF47
type: RelationshipXref
id: PTHR48019:SF47
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK3-RIGHT__MKK3-_re26
controller: TAK1

uniprot F6XZU9 90
type: UnificationXref
id: F6XZU9
db: uniprot

uniprot A0A1D5R1Y7 79
type: UnificationXref
id: A0A1D5R1Y7
db: uniprot

uniprot F7FRM2 238
type: UnificationXref
id: F7FRM2
db: uniprot

eIF4E
type: Protein
entity reference: eIF4E
feature: eIF4E s98 sa103 rs1
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_re49
controller: MAPKAP-K3

uniprot H2QMP5 225
type: UnificationXref
id: H2QMP5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MNK2-RIGHT__MNK2-_re38
controller: p38beta

uniprot Q52WY2 211
type: UnificationXref
id: Q52WY2
db: uniprot

Myocyte-specific enhancer factor 2D
type: ProteinReference
xref: uniprot Q63943 101
organism: Mus musculus

eEF2K
type: Protein
entity reference: eEF2K
feature: eEF2K s65 sa80 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Dual specificity protein phosphatase 1
type: ProteinReference
xref: uniprot Q64623 247
organism: Rattus norvegicus

PTHR48019:SF40
type: RelationshipXref
id: PTHR48019:SF40
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re31 267
type: Stoichiometry
physical entity: p38delta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 266
type: Stoichiometry
physical entity: p38delta
stoichiometric coefficient: 1.0

Rac family small GTPase 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot F7FH99 62
organism: Ornithorhynchus anatinus

TRAF6
type: Protein
entity reference: TRAF6
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

p38alpha
type: ProteinReference
xref: P06031
standard name: p38-alpha mitogen-activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: p38-alpha mitogen-activated protein kinase Synonym: CSAID-binding protein 1,CSBP1,MAPK14,SAPK2A,cytokine-suppressive antiinflammatory drug-binding protein 1,mitogen-activated protein kinase 14,stress-activated protein kinase 2A Accession: P06031
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.p38alpha
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 14B

uniprot Q8CDB0 38
type: UnificationXref
id: Q8CDB0
db: uniprot

MAP kinase interacting serine/threonine kinase 2
type: ProteinReference
xref: PTHR24349:SF254
xref: uniprot E1BCH7 35
organism: Bos taurus

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot P0C8E4 188
organism: Rattus norvegicus

uniprot P41969 11
type: UnificationXref
id: P41969
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A0G2K366 201
xref: PTHR24351:SF115
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__eIF4E-RIGHT__eIF4E-_re48
controller: MNK2

uniprot Q60929 100
type: UnificationXref
id: Q60929
db: uniprot

uniprot P28562 245
type: UnificationXref
id: P28562
db: uniprot

MEKK4
type: Protein
entity reference: MEKK4
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 89

MEF2D isoform 1
type: ProteinReference
xref: uniprot A0A2I3SAX9 82
organism: Pan troglodytes

uniprot F7HB38 49
type: UnificationXref
id: F7HB38
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot K7BI90 198
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ELK-RIGHT__ELK-_re43
controller: p38beta

uniprot F6Z879 171
type: UnificationXref
id: F6Z879
db: uniprot

uniprot F1MXH6 213
type: UnificationXref
id: F1MXH6
db: uniprot

STATE_TRANSITION_LEFT__eIF4E-RIGHT__eIF4E-_re48
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re48 275
participant stoichiometry: PARTICIPANT STOICHIOMETRY re48 276
left: eIF4E
interaction type: STATE_TRANSITION
right: eIF4E

GADD45
type: ProteinReference
xref: P06044
standard name: Growth arrest and DNA damage-inducible gene
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Growth arrest and DNA damage-inducible gene Synonym: DDIT1,DNA damage-inducible transcript 1 Accession: P06044
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.GADD45
member entity reference: Growth arrest and DNA damage-inducible protein GADD45 alpha
member entity reference: Uncharacterized protein
member entity reference: GADD45A isoform 1

Myocyte-specific enhancer factor 2C
type: ProteinReference
xref: PTHR11945:SF25
xref: uniprot Q8CFN5 103
organism: Mus musculus

uniprot F1PLP7 177
type: UnificationXref
id: F1PLP7
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot F7H6S1 185
organism: Macaca mulatta

STATE_TRANSITION_LEFT__p38delta-RIGHT__p38delta-_re31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 267
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 266
left: p38delta
interaction type: STATE_TRANSITION
right: p38delta

STATE_TRANSITION_LEFT__p38delta-RIGHT__p38delta-_re34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 261
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 260
left: p38delta
interaction type: STATE_TRANSITION
right: p38delta

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot O43318 187
xref: PTHR46716:SF1
organism: Homo sapiens

uniprot F1P593 25
type: UnificationXref
id: F1P593
db: uniprot

Eukaryotic translation initiation factor 4E
type: ProteinReference
xref: uniprot F6ZT05 108
organism: Xenopus tropicalis

uniprot Q5F3L1 206
type: UnificationXref
id: Q5F3L1
db: uniprot

uniprot Q9HBH9 39
type: UnificationXref
id: Q9HBH9
db: uniprot

uniprot H2QCA7 172
type: UnificationXref
id: H2QCA7
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot A0A3Q1LSJ2 121
organism: Bos taurus

STATE_TRANSITION_LEFT__MAPKAP_K2-RIGHT__MAPKAP_K2-_re45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re45 282
participant stoichiometry: PARTICIPANT STOICHIOMETRY re45 281
left: MAPKAP-K2
interaction type: STATE_TRANSITION
right: MAPKAP-K2

Dual specificity protein phosphatase 10
type: ProteinReference
xref: uniprot Q9Y6W6 242
xref: PTHR10159:SF299
organism: Homo sapiens

uniprot F6SDH6 197
type: UnificationXref
id: F6SDH6
db: uniprot

uniprot F1PSC3 107
type: UnificationXref
id: F1PSC3
db: uniprot

MSK1 s94 sa100 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.29
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot Q925D6 160
xref: PTHR48013:SF12
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__4EBP1-RIGHT__4EBP1-_re53
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re53 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY re53 305
left: 4EBP1
interaction type: STATE_TRANSITION
right: 4EBP1

uniprot P47809 174
type: UnificationXref
id: P47809
db: uniprot

P05922
type: UnificationXref
id: P05922
db: PANTHER Pathway Component

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: ProteinReference
xref: uniprot P24522 221
xref: PTHR10411:SF3
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HHY8 231
xref: PTHR24349:SF63
organism: Macaca mulatta

uniprot Q5F337 66
type: UnificationXref
id: Q5F337
db: uniprot

uniprot Q02779 132
type: UnificationXref
id: Q02779
db: uniprot

Myocyte enhancer factor 2A
type: ProteinReference
xref: PTHR11945:SF637
xref: uniprot F6XZU9 90
organism: Canis lupus familiaris

uniprot H2QIG4 140
type: UnificationXref
id: H2QIG4
db: uniprot

uniprot Q95NE7 151
type: UnificationXref
id: Q95NE7
db: uniprot

uniprot E2R9L4 122
type: UnificationXref
id: E2R9L4
db: uniprot

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot F7BFL2 224
organism: Macaca mulatta

uniprot O43318 187
type: UnificationXref
id: O43318
db: uniprot

MKP1
type: ProteinReference
xref: P05922
standard name: Mitogen activated protein kinase phosphatase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MKP1
comment: ENTITY_REFERENCE_NOTES= Long Name: MAPK phosphatase 1 Synonym: DUSP1,dual-specificity phosphatase 1 Accession: P05922
member entity reference: Dual specificity protein phosphatase
member entity reference: Dual specificity protein phosphatase 1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38delta-RIGHT__p38delta-_re31
controller: MKK3

uniprot Q9WUI1 138
type: UnificationXref
id: Q9WUI1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38alpha-RIGHT__p38alpha-_re23
controller: MKK4

P05919
type: UnificationXref
id: P05919
db: PANTHER Pathway Component

uniprot P13504 141
type: UnificationXref
id: P13504
db: uniprot

uniprot F6RBZ7 210
type: UnificationXref
id: F6RBZ7
db: uniprot

uniprot K7DH81 204
type: UnificationXref
id: K7DH81
db: uniprot

MEKK4
type: Protein
entity reference: MEKK4
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Dual specificity protein phosphatase 10
type: ProteinReference
xref: uniprot Q9ESS0 241
xref: PTHR10159:SF299
organism: Mus musculus

uniprot A0A2I3SAX9 82
type: UnificationXref
id: A0A2I3SAX9
db: uniprot

uniprot F7F8P2 73
type: UnificationXref
id: F7F8P2
db: uniprot

MKK4
type: Protein
entity reference: MKK4
feature: MKK4 s50 sa63 rs1
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

P05921
type: UnificationXref
id: P05921
db: PANTHER Pathway Component

MKK6 s45 sa58 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

P05920
type: UnificationXref
id: P05920
db: PANTHER Pathway Component

PTHR24351:SF115
type: RelationshipXref
id: PTHR24351:SF115
db: PANTHER Family
relationship type: By Homology

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: uniprot O01991 75
xref: PTHR45992:SF3
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY re21 312
type: Stoichiometry
physical entity: TAB1
stoichiometric coefficient: 1.0

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot E1BN61 203
xref: PTHR24351:SF115
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re21 311
type: Stoichiometry
physical entity: TAB1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MKK4-RIGHT__MKK4-_re27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 295
left: MKK4
interaction type: STATE_TRANSITION
right: MKK4

uniprot Q9DGE1 152
type: UnificationXref
id: Q9DGE1
db: uniprot

SRF isoform 1
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot K7D2P2 117
organism: Pan troglodytes

TNF receptor-associated factor 6
type: ProteinReference
xref: uniprot Q9Y4K3 194
organism: Homo sapiens

IL-6R/TRAF6 complex
type: Complex
component stoichiometry: TRAF6 s37 sa47 STOICHIOMETRY ID COMPLEX
component stoichiometry: IL 1R s38 sa46 STOICHIOMETRY ID COMPLEX
component: TRAF6
component: IL-1R
feature: COMPLEX BINDING FEATURE s36 csa1 250
feature: COMPLEX BINDING FEATURE s36 csa1 248
cellular location: cytoplasm

PARTICIPANT STOICHIOMETRY re23 304
type: Stoichiometry
physical entity: p38alpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 303
type: Stoichiometry
physical entity: p38alpha
stoichiometric coefficient: 1.0

Cyclic AMP-dependent transcription factor ATF-1
type: ProteinReference
xref: PTHR45879:SF2
xref: uniprot F7HB38 49
organism: Macaca mulatta

TRAF6
type: Protein
entity reference: TRAF6
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa47 251
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK4-RIGHT__MEKK4-_re28
controller: Cdc42

ncbitaxon 9913 15
type: UnificationXref
id: 9913
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK4-RIGHT__MKK4-_re27
controller: MLK2

Myocyte-specific enhancer factor 2D
type: ProteinReference
xref: uniprot O89038 94
organism: Rattus norvegicus

PTHR48013:SF12
type: RelationshipXref
id: PTHR48013:SF12
db: PANTHER Family
relationship type: By Homology

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

MEKK4
type: ProteinReference
xref: P06026
standard name: mitogen-activated protein kinase kinase kinase 4
comment: ENTITY_REFERENCE_NOTES= Long Name: mitogen-activated protein kinase kinase kinase 4 Synonym: MAP3K4,MAPK/ERK kinase kinase 4,MAPKKK4 Accession: P06026
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MEKK4
member entity reference: Mitogen-activated protein kinase kinase kinase 4
member entity reference: Uncharacterized protein

Bos taurus
type: BioSource
xref: ncbitaxon 9913 15

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: PTHR24349:SF254
xref: uniprot Q8CDB0 38
organism: Mus musculus

uniprot K7CFQ9 215
type: UnificationXref
id: K7CFQ9
db: uniprot

uniprot Q9Y6W6 242
type: UnificationXref
id: Q9Y6W6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38alpha-RIGHT__p38alpha-_re23
controller: TAB1

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot P49138 234
organism: Mus musculus

uniprot F7G4D2 116
type: UnificationXref
id: F7G4D2
db: uniprot

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot P49137 233
organism: Homo sapiens

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 63

PTHR48013:SF21
type: RelationshipXref
id: PTHR48013:SF21
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot P70236 158
xref: PTHR48013:SF12
organism: Mus musculus

PTHR48013:SF20
type: RelationshipXref
id: PTHR48013:SF20
db: PANTHER Family
relationship type: By Homology

uniprot E1B7Z0 161
type: UnificationXref
id: E1B7Z0
db: uniprot

Mitogen-activated protein kinase kinase kinase 10
type: ProteinReference
xref: uniprot D3ZG83 130
xref: PTHR44329:SF39
organism: Rattus norvegicus

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P14602 32
organism: Mus musculus

p38beta
type: ProteinReference
xref: P06029
standard name: p38-beta mitogen-activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: p38-beta mitogen-activated protein kinase Synonym: MAPK11,SAPK2B,mitogen-activated protein kinase 11,stressed-activated protein kinase 2B Accession: P06029
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.p38beta
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase

MKK4
type: ProteinReference
xref: P06034
standard name: mitogen-activated protein kinase kinase 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: mitogen-activated protein kinase kinase 4 Synonym: JNK-activated kinase 1,JNKK1,MAP2K4,MAPK/ERK kinase 4,MAPKK4,MEK4,SAPK/ERK kinase 1,SEK1,SERK1 Accession: P06034
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MKK4
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase 4
member entity reference: Uncharacterized protein
member entity reference: MAP2K4 isoform 3
member entity reference: MAP2K4 protein

TAB1
type: ProteinReference
xref: P06035
standard name: TAK1 binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.TAB1
comment: ENTITY_REFERENCE_NOTES= Long Name: TAK1 binding protein Synonym: MAP3K7IP1,mitogen-activated protein kinase kinase kinase 7-interacting protein 1 Accession: P06035
member entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
member entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
member entity reference: RCG59826
member entity reference: TGF-beta activated kinase 1 (MAP3K7) binding protein 1

MSK2
type: Protein
entity reference: MSK2
feature: ACTIVE 13
feature: MSK2 s93 sa99 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAP2K4 protein
type: ProteinReference
xref: uniprot A5PJP8 169
xref: PTHR48013:SF15
organism: Bos taurus

uniprot A0A0G2K3R1 120
type: UnificationXref
id: A0A0G2K3R1
db: uniprot

Rac
type: Protein
entity reference: Rac
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CREB
type: ProteinReference
xref: P06027
standard name: cAMP response element binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.CREB
comment: ENTITY_REFERENCE_NOTES= Long Name: cAMP response element binding protein Synonym: Synonym not specified Accession: P06027
member entity reference: cAMP responsive element binding protein 1
member entity reference: cAMP response element-binding protein
member entity reference: cAMP-responsive element-binding protein 1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK3-RIGHT__MKK3-_re26
controller: ASK1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38alpha-RIGHT__p38alpha-_re36
controller: MKP1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38gamma-RIGHT__p38gamma-_re33
controller: MKP5

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 17

TRANSPORT_LEFT__p38alpha-RIGHT__p38alpha-_re24
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 302
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 301
left: p38alpha
interaction type: TRANSPORT
right: p38alpha

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEF-RIGHT__MEF-_re42
controller: p38beta

MEF
type: Protein
entity reference: MEF
feature: MEF s78 sa91 rs1
feature: ACTIVE 13
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

GTPase cRac1A
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6LC82 69
organism: Gallus gallus

uniprot E1BJP4 113
type: UnificationXref
id: E1BJP4
db: uniprot

uniprot P70531 78
type: UnificationXref
id: P70531
db: uniprot

HSPB1 isoform 1
type: ProteinReference
xref: uniprot H2QUT1 28
xref: PTHR45640:SF7
organism: Pan troglodytes

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot H2RCY2 186
organism: Pan troglodytes

uniprot K7D2P2 117
type: UnificationXref
id: K7D2P2
db: uniprot

uniprot B5DF45 190
type: UnificationXref
id: B5DF45
db: uniprot

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: PTHR45992:SF3
xref: uniprot O00418 74
organism: Homo sapiens

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 26

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot F7FP88 115
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re37 255
type: Stoichiometry
physical entity: eEF2K
stoichiometric coefficient: 1.0

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
type: ProteinReference
xref: uniprot Q9NYJ8 167
organism: Homo sapiens

HSP27
type: Protein
entity reference: HSP27
feature: HSP27 s110 sa111 rs1
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Z1B7 60
type: UnificationXref
id: Q9Z1B7
db: uniprot

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot F1PH12 114
organism: Canis lupus familiaris

ncbitaxon 9544 19
type: UnificationXref
id: 9544
db: ncbitaxon

ATF1
type: Protein
entity reference: ATF1
feature: ATF1 s107 sa109 rs1
feature: ACTIVE 13
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q3T0N5 57
type: UnificationXref
id: Q3T0N5
db: uniprot

Myocyte enhancer factor 2B
type: ProteinReference
xref: uniprot Q6AXR7 102
organism: Rattus norvegicus

uniprot F7H8X1 178
type: UnificationXref
id: F7H8X1
db: uniprot

STATE_TRANSITION_LEFT__TAB2-RIGHT__TAB2-_re20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 315
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 316
left: TAB2
interaction type: STATE_TRANSITION
right: TAB2

p38gamma s58 sa73 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

MNK1
type: Protein
entity reference: MNK1
feature: MNK1 s68 sa84 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

MSK2 s93 sa99 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MAPKAP-K3
type: ProteinReference
xref: P05919
standard name: MAPK-activated protein kinase 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MAPKAP_minus_K3
comment: ENTITY_REFERENCE_NOTES= Long Name: MAPK-activated protein kinase 3 Synonym: 3PK Accession: P05919
member entity reference: MAP kinase-activated protein kinase 3
member entity reference: MAPKAPK3 isoform 1

uniprot Q8C050 207
type: UnificationXref
id: Q8C050
db: uniprot

PARTICIPANT STOICHIOMETRY re51 314
type: Stoichiometry
physical entity: ATF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re51 313
type: Stoichiometry
physical entity: ATF1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_re52
controller: MAPKAP-K3

uniprot H2QGC0 131
type: UnificationXref
id: H2QGC0
db: uniprot

Interleukin-1 receptor type 1
type: ProteinReference
xref: uniprot Q02955 143
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_re49
controller: MAPKAP-K2

PTHR11584:SF332
type: RelationshipXref
id: PTHR11584:SF332
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot P70618 149
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_re52
controller: MAPKAP-K2

Myocyte-specific enhancer factor 2
type: ProteinReference
xref: uniprot P40791 95
organism: Drosophila melanogaster

cAMP-responsive element-binding protein 1
type: ProteinReference
xref: uniprot F6QA46 126
xref: PTHR45879:SF1
organism: Xenopus tropicalis

uniprot Q16539 150
type: UnificationXref
id: Q16539
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot F6SDH6 197
organism: Macaca mulatta

TAB2
type: Protein
entity reference: TAB2
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0U1RRU5 175
type: UnificationXref
id: A0A0U1RRU5
db: uniprot

uniprot P42930 34
type: UnificationXref
id: P42930
db: uniprot

PARTICIPANT STOICHIOMETRY re33 263
type: Stoichiometry
physical entity: p38gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 262
type: Stoichiometry
physical entity: p38gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re52 309
type: Stoichiometry
physical entity: HSP27
stoichiometric coefficient: 1.0

Dual specificity protein phosphatase 1
type: ProteinReference
xref: uniprot P28563 246
organism: Mus musculus

Dual specificity protein phosphatase 1
type: ProteinReference
xref: uniprot P28562 245
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re52 310
type: Stoichiometry
physical entity: HSP27
stoichiometric coefficient: 1.0

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
type: ProteinReference
xref: uniprot Q99K90 166
organism: Mus musculus

ASK1
type: Protein
entity reference: ASK1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MEKK4-RIGHT__MEKK4-_re28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 293
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 294
left: MEKK4
interaction type: STATE_TRANSITION
right: MEKK4

ncbitaxon 13616 48
type: UnificationXref
id: 13616
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F337 66
xref: PTHR24072:SF169
organism: Gallus gallus

eIF4E s97 sa102 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.29
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot D3ZSB7 195
organism: Rattus norvegicus

ELK s79 sa92 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

uniprot F6ZTS0 18
type: UnificationXref
id: F6ZTS0
db: uniprot

uniprot F7GDU1 239
type: UnificationXref
id: F7GDU1
db: uniprot

uniprot Q63538 24
type: UnificationXref
id: Q63538
db: uniprot

uniprot Q58D94 44
type: UnificationXref
id: Q58D94
db: uniprot

uniprot A2VDZ3 85
type: UnificationXref
id: A2VDZ3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F6Z879 171
organism: Monodelphis domestica

uniprot Q15759 137
type: UnificationXref
id: Q15759
db: uniprot

p38beta
type: Protein
entity reference: p38beta
feature: ACTIVE 13
feature: p38beta s62 sa77 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot A0A3Q1LJZ7 14
organism: Bos taurus

MKK3
type: ProteinReference
xref: P06036
standard name: mitogen-activated protein kinase kinase 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: mitogen-activated protein kinase kinase 3 Synonym: MAP2K3,MAPK/ERK kinase 3,MAPKK3,MEK3 Accession: P06036
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MKK3
member entity reference: Mitogen-activated protein kinase kinase 3

PARTICIPANT STOICHIOMETRY re20 315
type: Stoichiometry
physical entity: TAB2
stoichiometric coefficient: 1.0

p38delta
type: Protein
entity reference: p38delta
feature: p38delta s59 sa74 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR24349:SF114
type: RelationshipXref
id: PTHR24349:SF114
db: PANTHER Family
relationship type: By Homology

uniprot F6QA46 126
type: UnificationXref
id: F6QA46
db: uniprot

PTHR45992:SF3
type: RelationshipXref
id: PTHR45992:SF3
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1M614 230
type: UnificationXref
id: A0A3Q1M614
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot A0A1D5QAU9 168
organism: Macaca mulatta

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
type: ProteinReference
xref: uniprot F6VE69 163
organism: Macaca mulatta

Rac
type: ProteinReference
xref: P06021
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_NOTES= Long Name: Rac GTPase Synonym: RAS-related C3 botulinum toxin substrate Accession: P06021
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.Rac
member entity reference: GTPase cRac1A
member entity reference: Rac family small GTPase 3a
member entity reference: Rac family small GTPase 3b
member entity reference: Uncharacterized protein
member entity reference: Rac family small GTPase 1b
member entity reference: Rac family small GTPase 2
member entity reference: Ras-related C3 botulinum toxin substrate 2

uniprot E2R7W7 155
type: UnificationXref
id: E2R7W7
db: uniprot

Cell division cycle 42
type: ProteinReference
xref: PTHR24072:SF337
xref: uniprot Q52WY2 211
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re28 294
type: Stoichiometry
physical entity: MEKK4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 293
type: Stoichiometry
physical entity: MEKK4
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38beta-RIGHT__p38beta-_re32
controller: MKK4

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot E2RSB0 16
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__eEF2K-RIGHT__eEF2K-_re37
controller: p38delta

PARTICIPANT STOICHIOMETRY re20 316
type: Stoichiometry
physical entity: TAB2
stoichiometric coefficient: 1.0

CHOP10 s70 sa86 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.11

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot P52564 157
xref: PTHR48013:SF12
organism: Homo sapiens

PTHR24072:SF337
type: RelationshipXref
id: PTHR24072:SF337
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TAK1-RIGHT__TAK1-_re22
controller: TAB1

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9WTY9 59
xref: PTHR24055:SF107
organism: Rattus norvegicus

TNF receptor-associated factor 6
type: ProteinReference
xref: uniprot P70196 193
organism: Mus musculus

uniprot F1MQE1 196
type: UnificationXref
id: F1MQE1
db: uniprot

Ribosomal protein S6 kinase alpha-4
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot Q9Z2B9 200
organism: Mus musculus

IL-1R
type: Protein
entity reference: IL-1R
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: ProteinReference
xref: PTHR10411:SF3
xref: uniprot P48316 222
organism: Mus musculus

uniprot A0A2I3TT58 176
type: UnificationXref
id: A0A2I3TT58
db: uniprot

MKK6
type: Protein
entity reference: MKK6
feature: MKK6 s47 sa60 rs1
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot F7AGV5 156
xref: PTHR48013:SF12
organism: Monodelphis domestica

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

GO GO:0005737 3
type: UnificationXref
id: GO:0005737
db: GO

PARTICIPANT STOICHIOMETRY re30 269
type: Stoichiometry
physical entity: p38gamma
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__p38alpha-RIGHT__p38alpha-_re23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 303
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 304
left: p38alpha
interaction type: STATE_TRANSITION
right: p38alpha

PARTICIPANT STOICHIOMETRY re30 268
type: Stoichiometry
physical entity: p38gamma
stoichiometric coefficient: 1.0

Cdc42
type: ProteinReference
xref: P06041
standard name: cell division cycle 42
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.Cdc42
comment: ENTITY_REFERENCE_NOTES= Long Name: cell division cycle 42 Synonym: G25K,GTP-binding protein, 25KD Accession: P06041
member entity reference: Uncharacterized protein
member entity reference: Cell division control protein 42 homolog isoform 2
member entity reference: Cell division control protein 42 homolog
member entity reference: Cell division cycle 42

ncbitaxon 10116 5
type: UnificationXref
id: 10116
db: ncbitaxon

MKP5
type: ProteinReference
xref: P05921
standard name: Mitogen activated protein kinase phosphatase 5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MKP5
comment: ENTITY_REFERENCE_NOTES= Long Name: MAPK phosphatase 5 Synonym: DUSP10,dual-specificity phosphatase 10 Accession: P05921
member entity reference: Dual specificity phosphatase 10
member entity reference: Dual specificity phosphatase 10 (Predicted)
member entity reference: Dual specificity protein phosphatase 10
member entity reference: Uncharacterized protein

PARTICIPANT STOICHIOMETRY re50 317
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re50 318
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Rac family small GTPase 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q5U1Y2 67
organism: Rattus norvegicus

uniprot Q6AXR7 102
type: UnificationXref
id: Q6AXR7
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

ATF1 isoform 2
type: ProteinReference
xref: PTHR45879:SF2
xref: uniprot H2Q5X1 50
organism: Pan troglodytes

eco ECO:0000304 217
type: UnificationXref
id: ECO:0000304
db: eco

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4EBP1-RIGHT__4EBP1-_re53
controller: MSK2

uniprot A0A1D5RIU2 80
type: UnificationXref
id: A0A1D5RIU2
db: uniprot

ELK s81 sa93 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

STATE_TRANSITION_LEFT__p38alpha-RIGHT__p38alpha-_re36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 256
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 257
left: p38alpha
interaction type: STATE_TRANSITION
right: p38alpha

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q90694 212
organism: Gallus gallus

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A1D5Q3X8 202
xref: PTHR24351:SF115
organism: Macaca mulatta

uniprot P0C8E4 188
type: UnificationXref
id: P0C8E4
db: uniprot

uniprot O75582 205
type: UnificationXref
id: O75582
db: uniprot

uniprot E2RIJ6 72
type: UnificationXref
id: E2RIJ6
db: uniprot

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: uniprot O08796 77
xref: PTHR45992:SF3
organism: Mus musculus

TAK1
type: Protein
entity reference: TAK1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Myocyte enhancer factor 2C
type: ProteinReference
xref: PTHR11945:SF25
xref: uniprot F7FK48 91
organism: Ornithorhynchus anatinus

uniprot F7GVA6 139
type: UnificationXref
id: F7GVA6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TAB1-RIGHT__TAB1-_re21
controller: IL-6R/TRAF6 complex

PTHR45879:SF1
type: RelationshipXref
id: PTHR45879:SF1
db: PANTHER Family
relationship type: By Homology

IL 1R s38 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IL-1R
stoichiometric coefficient: 1.0

PTHR45879:SF2
type: RelationshipXref
id: PTHR45879:SF2
db: PANTHER Family
relationship type: By Homology

p38gamma
type: Protein
entity reference: p38gamma
feature: ACTIVE 13
feature: p38gamma s58 sa73 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Dual specificity protein phosphatase 10
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot Q0IID7 240
organism: Bos taurus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot O02812 147
organism: Canis lupus familiaris

uniprot Q63943 101
type: UnificationXref
id: Q63943
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RKA7 54
xref: PTHR24055:SF107
organism: Canis lupus familiaris

PTHR24072:SF192
type: RelationshipXref
id: PTHR24072:SF192
db: PANTHER Family
relationship type: By Homology

uniprot Q3UMW7 228
type: UnificationXref
id: Q3UMW7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MSK1-RIGHT__MSK1-_re47
controller: p38beta

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot Q99683 218
xref: PTHR11584:SF332
organism: Homo sapiens

eEF2K
type: Protein
entity reference: eEF2K
feature: eEF2K s66 sa81 rs1
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q3SYZ2 227
type: UnificationXref
id: Q3SYZ2
db: uniprot

TAK1
type: Protein
entity reference: TAK1
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot P19419 8
xref: PTHR11849:SF178
organism: Homo sapiens

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 9

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re48 275
type: Stoichiometry
physical entity: eIF4E
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re48 276
type: Stoichiometry
physical entity: eIF4E
stoichiometric coefficient: 1.0

TGF-beta activated kinase 1 (MAP3K7) binding protein 1
type: ProteinReference
xref: uniprot A0A2I3TT58 176
xref: PTHR13832:SF533
organism: Pan troglodytes

Cdc42
type: Protein
entity reference: Cdc42
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK4-RIGHT__MKK4-_re27
controller: MEKK4

Ribosomal protein S6 kinase alpha-4
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot O75676 199
organism: Homo sapiens

ncbitaxon 9615 17
type: UnificationXref
id: 9615
db: ncbitaxon

p38beta
type: Protein
entity reference: p38beta
feature: p38beta s61 sa76 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P70618 149
type: UnificationXref
id: P70618
db: uniprot

uniprot P81269 52
type: UnificationXref
id: P81269
db: uniprot

uniprot F6V332 145
type: UnificationXref
id: F6V332
db: uniprot

uniprot F7AGV5 156
type: UnificationXref
id: F7AGV5
db: uniprot

PTHR24351:SF41
type: RelationshipXref
id: PTHR24351:SF41
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9N272 58
xref: PTHR24055:SF107
organism: Pan troglodytes

uniprot O01991 75
type: UnificationXref
id: O01991
db: uniprot

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

MAP3K5 isoform 1
type: ProteinReference
xref: uniprot K7CFQ9 215
xref: PTHR11584:SF332
organism: Pan troglodytes

IL-1R
type: Protein
entity reference: IL-1R
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa46 249
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2
type: ProteinReference
xref: PTHR24349:SF254
xref: uniprot H9EP11 36
organism: Macaca mulatta

uniprot Q5U1Y2 67
type: UnificationXref
id: Q5U1Y2
db: uniprot

uniprot Q5U2N4 37
type: UnificationXref
id: Q5U2N4
db: uniprot

uniprot H2QS06 244
type: UnificationXref
id: H2QS06
db: uniprot

uniprot P49138 234
type: UnificationXref
id: P49138
db: uniprot

Myocyte-specific enhancer factor 2C
type: ProteinReference
xref: PTHR11945:SF25
xref: uniprot Q06413 98
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot F6TXC2 55
organism: Monodelphis domestica

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: uniprot Q66H84 229
xref: PTHR24349:SF64
organism: Rattus norvegicus

uniprot P40791 95
type: UnificationXref
id: P40791
db: uniprot

uniprot Q05144 64
type: UnificationXref
id: Q05144
db: uniprot

STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_re49
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re49 274
participant stoichiometry: PARTICIPANT STOICHIOMETRY re49 273
left: SRF
interaction type: STATE_TRANSITION
right: SRF

P06023
type: UnificationXref
id: P06023
db: PANTHER Pathway Component

P06022
type: UnificationXref
id: P06022
db: PANTHER Pathway Component

P06021
type: UnificationXref
id: P06021
db: PANTHER Pathway Component

P06020
type: UnificationXref
id: P06020
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re26 297
type: Stoichiometry
physical entity: MKK3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 298
type: Stoichiometry
physical entity: MKK3
stoichiometric coefficient: 1.0

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

P06029
type: UnificationXref
id: P06029
db: PANTHER Pathway Component

P06028
type: UnificationXref
id: P06028
db: PANTHER Pathway Component

P06027
type: UnificationXref
id: P06027
db: PANTHER Pathway Component

P06026
type: UnificationXref
id: P06026
db: PANTHER Pathway Component

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6V332 145
organism: Macaca mulatta

P06025
type: UnificationXref
id: P06025
db: PANTHER Pathway Component

P06024
type: UnificationXref
id: P06024
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR11945:SF25
xref: uniprot F7FXI4 92
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re40 290
type: Stoichiometry
physical entity: CHOP10
stoichiometric coefficient: 1.0

uniprot F7C798 135
type: UnificationXref
id: F7C798
db: uniprot

MLK2
type: Protein
entity reference: MLK2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot A0A3Q1LTT9 144
organism: Bos taurus

uniprot P70196 193
type: UnificationXref
id: P70196
db: uniprot

uniprot A0A2I3S0F9 81
type: UnificationXref
id: A0A2I3S0F9
db: uniprot

uniprot E2R3R6 183
type: UnificationXref
id: E2R3R6
db: uniprot

uniprot Q66L42 133
type: UnificationXref
id: Q66L42
db: uniprot

ncbitaxon 9031 26
type: UnificationXref
id: 9031
db: ncbitaxon

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

uniprot Q8CFN5 103
type: UnificationXref
id: Q8CFN5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38alpha-RIGHT__p38alpha-_re23
controller: MKK3

Mitogen-activated protein kinase kinase kinase 10
type: ProteinReference
xref: PTHR44329:SF39
xref: uniprot Q66L42 133
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK4-RIGHT__MKK4-_re27
controller: ASK1

MSK2 s91 sa98 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

uniprot Q9D6Y4 104
type: UnificationXref
id: Q9D6Y4
db: uniprot

P06018
type: UnificationXref
id: P06018
db: PANTHER Pathway Component

P06017
type: UnificationXref
id: P06017
db: PANTHER Pathway Component

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

P06019
type: UnificationXref
id: P06019
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CHOP10-RIGHT__CHOP10-_re40
controller: p38alpha

P06013
type: UnificationXref
id: P06013
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38gamma-RIGHT__p38gamma-_re33
controller: MKP1

P06016
type: UnificationXref
id: P06016
db: PANTHER Pathway Component

P06015
type: UnificationXref
id: P06015
db: PANTHER Pathway Component

uniprot Q99683 218
type: UnificationXref
id: Q99683
db: uniprot

uniprot Q02955 143
type: UnificationXref
id: Q02955
db: uniprot

cAMP responsive element binding protein 1
type: ProteinReference
xref: uniprot F7FD05 127
xref: PTHR45879:SF1
organism: Monodelphis domestica

MLK2
type: Protein
entity reference: MLK2
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Y4K3 194
type: UnificationXref
id: Q9Y4K3
db: uniprot

Dual specificity phosphatase 10 (Predicted)
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot D3ZBG7 235
organism: Rattus norvegicus

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q05144 64
organism: Mus musculus

MSK1 s96 sa101 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.29
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re43 284
type: Stoichiometry
physical entity: ELK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re43 283
type: Stoichiometry
physical entity: ELK
stoichiometric coefficient: 1.0

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 217

P06041
type: UnificationXref
id: P06041
db: PANTHER Pathway Component

P06040
type: UnificationXref
id: P06040
db: PANTHER Pathway Component

P06044
type: UnificationXref
id: P06044
db: PANTHER Pathway Component

uniprot D3ZBG7 235
type: UnificationXref
id: D3ZBG7
db: uniprot

P06043
type: UnificationXref
id: P06043
db: PANTHER Pathway Component

ncbitaxon 9598 29
type: UnificationXref
id: 9598
db: ncbitaxon

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
evidence: Evidence 46
xref: PTHR24349:SF114
xref: uniprot Q9BUB5 45
organism: Homo sapiens

uniprot P14778 142
type: UnificationXref
id: P14778
db: uniprot

uniprot F6R2J2 162
type: UnificationXref
id: F6R2J2
db: uniprot

4EBP1 s113 sa113 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.22
comment: MODIFICATION_RESIDUE_NAME=

uniprot A0A3Q1LSJ2 121
type: UnificationXref
id: A0A3Q1LSJ2
db: uniprot

Evidence 41
type: Evidence
evidence code: ISS
comment: SPACC Q9BUB5

uniprot E1BCH7 35
type: UnificationXref
id: E1BCH7
db: uniprot

P06030
type: UnificationXref
id: P06030
db: PANTHER Pathway Component

P06032
type: UnificationXref
id: P06032
db: PANTHER Pathway Component

uniprot Q0IID7 240
type: UnificationXref
id: Q0IID7
db: uniprot

PARTICIPANT STOICHIOMETRY re49 274
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

Evidence 46
type: Evidence
evidence code: IDA
comment: SPACC Q9BUB5

P06031
type: UnificationXref
id: P06031
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re49 273
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

P06034
type: UnificationXref
id: P06034
db: PANTHER Pathway Component

P06033
type: UnificationXref
id: P06033
db: PANTHER Pathway Component

P06036
type: UnificationXref
id: P06036
db: PANTHER Pathway Component

Eukaryotic translation initiation factor 4E
type: ProteinReference
xref: uniprot P06730 109
organism: Homo sapiens

P06035
type: UnificationXref
id: P06035
db: PANTHER Pathway Component

P06038
type: UnificationXref
id: P06038
db: PANTHER Pathway Component

MLK2
type: ProteinReference
xref: P06028
standard name: mixed lineage kinase 2
comment: ENTITY_REFERENCE_ID_DESC=p38 MAPK pathway.PROTEIN.GENERIC.MLK2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: mixed lineage kinase 2 Synonym: MAP3K10,mitogen-activated protein kinase kinase kinase 10 Accession: P06028
member entity reference: Mitogen-activated protein kinase kinase kinase 10
member entity reference: Mitogen-activated protein kinase kinase kinase

P06037
type: UnificationXref
id: P06037
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38delta-RIGHT__p38delta-_re34
controller: MKP5

P06039
type: UnificationXref
id: P06039
db: PANTHER Pathway Component

uniprot F6VE69 163
type: UnificationXref
id: F6VE69
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GVA6 139
organism: Macaca mulatta

MEF s78 sa91 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

STATE_TRANSITION_LEFT__MKK3-RIGHT__MKK3-_re26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 298
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 297
left: MKK3
interaction type: STATE_TRANSITION
right: MKK3

uniprot F7CCD5 184
type: UnificationXref
id: F7CCD5
db: uniprot

uniprot D3ZG83 130
type: UnificationXref
id: D3ZG83
db: uniprot

PARTICIPANT STOICHIOMETRY re19 272
type: Stoichiometry
physical entity: IL-6R/TRAF6 complex
stoichiometric coefficient: 1.0

uniprot Q5E9X2 159
type: UnificationXref
id: Q5E9X2
db: uniprot

PARTICIPANT STOICHIOMETRY re19 271
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 270
type: Stoichiometry
physical entity: IL-1R
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q3T0N5 57
organism: Bos taurus

uniprot O15264 56
type: UnificationXref
id: O15264
db: uniprot

ELK
type: Protein
entity reference: ELK
feature: ELK s79 sa92 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MNK2-RIGHT__MNK2-_re38
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 252
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 253
left: MNK2
interaction type: STATE_TRANSITION
right: MNK2

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38alpha-RIGHT__p38alpha-_re36
controller: MKP5

STATE_TRANSITION
type: InteractionVocabulary

STATE_TRANSITION_LEFT__TAB1-RIGHT__TAB1-_re21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 311
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 312
left: TAB1
interaction type: STATE_TRANSITION
right: TAB1

TRANSPORT
type: InteractionVocabulary

uniprot F6YAB9 146
type: UnificationXref
id: F6YAB9
db: uniprot

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

Eukaryotic translation initiation factor 4E
type: ProteinReference
xref: uniprot F1PSC3 107
organism: Canis lupus familiaris

Interleukin-1 receptor type 1
type: ProteinReference
xref: uniprot P13504 141
organism: Mus musculus

ncbitaxon 8364 89
type: UnificationXref
id: 8364
db: ncbitaxon

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q16539 150
organism: Homo sapiens

CHOP10 s72 sa87 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.11

Myocyte-specific enhancer factor 2A
type: ProteinReference
xref: uniprot Q60929 100
xref: PTHR11945:SF637
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re38 252
type: Stoichiometry
physical entity: MNK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re38 253
type: Stoichiometry
physical entity: MNK2
stoichiometric coefficient: 1.0

uniprot A0A0G2K366 201
type: UnificationXref
id: A0A0G2K366
db: uniprot

HSP27 s108 sa110 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.44
comment: MODIFICATION_RESIDUE_NAME=

Heat shock protein family B (small) member 1
type: ProteinReference
xref: uniprot F1P593 25
organism: Gallus gallus

MAPKAP K3 s87 sa89 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

eEF2K s66 sa81 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.97
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

p38gamma
type: Protein
entity reference: p38gamma
feature: p38gamma s57 sa72 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q6LC82 69
type: UnificationXref
id: Q6LC82
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK6-RIGHT__MKK6-_re25
controller: ASK1

MAPKAP K3 s86 sa88 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

Dual specificity phosphatase 10
type: ProteinReference
xref: uniprot F7GDU1 239
xref: PTHR10159:SF299
organism: Ornithorhynchus anatinus

p38beta s62 sa77 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.4

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot A0A0G2K3R1 120
organism: Rattus norvegicus

uniprot F1MI99 243
type: UnificationXref
id: F1MI99
db: uniprot

MNK1 s69 sa85 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.33

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38beta-RIGHT__p38beta-_re32
controller: MKK3

PARTICIPANT STOICHIOMETRY re40 289
type: Stoichiometry
physical entity: CHOP10
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot F6U725 237
organism: Monodelphis domestica

uniprot H2QTW1 164
type: UnificationXref
id: H2QTW1
db: uniprot

uniprot D3ZSB7 195
type: UnificationXref
id: D3ZSB7
db: uniprot

uniprot O02812 147
type: UnificationXref
id: O02812
db: uniprot

SRF
type: Protein
entity reference: SRF
feature: SRF s99 sa104 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MNK1
type: Protein
entity reference: MNK1
feature: MNK1 s69 sa85 rs1
feature: ACTIVE 13
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A5PJP8 169
type: UnificationXref
id: A5PJP8
db: uniprot

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: PTHR24349:SF114
xref: uniprot Q58D94 44
organism: Bos taurus

RCG59826
type: ProteinReference
xref: uniprot A0A0U1RRU5 175
xref: PTHR13832:SF533
organism: Rattus norvegicus

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: uniprot F7F8P2 73
xref: PTHR45992:SF3
organism: Macaca mulatta

MAPKAP-K3
type: Protein
entity reference: MAPKAP-K3
feature: ACTIVE 13
feature: MAPKAP K3 s87 sa89 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__p38beta-RIGHT__p38beta-_re32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 265
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 264
left: p38beta
interaction type: STATE_TRANSITION
right: p38beta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TAK1-RIGHT__TAK1-_re22
controller: TAB2

STATE_TRANSITION_LEFT__p38beta-RIGHT__p38beta-_re35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 258
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 259
left: p38beta
interaction type: STATE_TRANSITION
right: p38beta