PARTICIPANT STOICHIOMETRY re5 520
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Uncharacterized protein
type: DnaReference
organism: Bos taurus

uniprot H2Q9S3 115
type: UnificationXref
id: H2Q9S3
db: uniprot

PARTICIPANT STOICHIOMETRY re5 521
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re58 543
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

14-3-3 protein sigma
type: DnaReference
xref: PTHR18860:SF14
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re58 544
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

Cyclin B
type: Protein
entity reference: Cyclin B
comment: SPECIES_TYPE=PROTEIN

uniprot F7GZG4 245
type: UnificationXref
id: F7GZG4
db: uniprot

uniprot P61957 388
type: UnificationXref
id: P61957
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: Apaf

TRANSCRIPTION_LEFT__Scotin-RIGHT__Scotin-_re99
type: TemplateReaction
product: Scotin
xref: TRANSCRIPTION
participant: Scotin
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Growth arrest and DNA damage inducible gamma
type: ProteinReference
xref: PTHR10411:SF4
xref: uniprot A0A452DI17 239
organism: Bos taurus

CDKN2D isoform 1
type: ProteinReference
xref: uniprot A0A2J8LWA9 405
organism: Pan troglodytes

Protein kinase rad3
type: ProteinReference
xref: PTHR11139:SF69
xref: uniprot Q02099 79
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY re15 511
type: Stoichiometry
physical entity: Complex (Sin3/HDAC1)
stoichiometric coefficient: 1.0

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

SIRT-1
type: ProteinReference
xref: P04632
standard name: Sirtuin
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.SIRT_minus_1
comment: ENTITY_REFERENCE_NOTES=Long Name: Sirtuin Synonym: Sir2 Accession: P04632
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: SIRT1 isoform 2
member entity reference: NAD-dependent protein deacetylase sirtuin-1
member entity reference: Uncharacterized protein

PARTICIPANT STOICHIOMETRY re15 510
type: Stoichiometry
physical entity: HDAC1
stoichiometric coefficient: 1.0

14-3-3 protein sigma
type: ProteinReference
xref: uniprot O70456 267
xref: PTHR18860:SF14
organism: Mus musculus

Histone acetyltransferase HAC4
type: ProteinReference
xref: uniprot Q9LG11 188
xref: PTHR13808:SF30
organism: Arabidopsis thaliana

PTEN
type: DnaRegion
entity reference: phospatase and tensin homologue
comment: SPECIES_TYPE=GENE

Akt
type: Protein
entity reference: Akt
feature: Akt s10 sa9 rs1
comment: SPECIES_TYPE=PROTEIN

Os01g0872800 protein
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q8RUE8 104
organism: Oryza sativa

uniprot Q9FLZ5 203
type: UnificationXref
id: Q9FLZ5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Gallus gallus

PTHR45750:SF2
type: RelationshipXref
id: PTHR45750:SF2
db: PANTHER Family
relationship type: By Homology

Sin3 s2 sa157 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Sin3
stoichiometric coefficient: 1.0

Mus musculus
type: BioSource
xref: ncbitaxon 10090 8

uniprot P29619 368
type: UnificationXref
id: P29619
db: uniprot

IGF-BP3
type: RnaRegion
comment: SPECIES_TYPE=RNA

uniprot F7B0D4 163
type: UnificationXref
id: F7B0D4
db: uniprot

Seven in absentia homolog 1
type: DnaRegionReference
member entity reference: E3 ubiquitin-protein ligase SIAH1
member entity reference: E3 ubiquitin-protein ligase
member entity reference: E3 ubiquitin-protein ligase SIAH1A
member entity reference: E3 ubiquitin-protein ligase SIAH1B
member entity reference: E3 ubiquitin-protein ligase Siah1
xref: G04696
comment: ENTITY_REFERENCE_NOTES=Long Name: Seven in absentia homolog 1 Synonym: Synonym not specified Accession: G04696
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.Siah
display name: Siah

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot F1MYE6 221
organism: Bos taurus

High mobility group protein B1
type: ProteinReference
xref: uniprot Q9YH06 129
organism: Gallus gallus

Tumor necrosis factor receptor superfamily member 6
type: DnaReference
xref: PTHR46874:SF1
organism: Mus musculus

Apoptosis-inducing factor 2
type: DnaReference
organism: Macaca mulatta

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__PCAF-RIGHT__PCAF-_re122
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

ncbitaxon 6239 179
type: UnificationXref
id: 6239
db: ncbitaxon

Cyclin G
type: DnaRegionReference
member entity reference: CCNG1 isoform 2
member entity reference: Cyclin-G1
member entity reference: Uncharacterized protein
member entity reference: Cyclin G1
xref: G04689
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclin G Synonym: CCNG,Cyclin G1 Accession: G04689
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.Cyclin G

STATE_TRANSITION_LEFT__P300-RIGHT__P300-_re118
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re118 469
participant stoichiometry: PARTICIPANT STOICHIOMETRY re118 470
left: P300
interaction type: STATE_TRANSITION
right: P300

uniprot F6SW23 350
type: UnificationXref
id: F6SW23
db: uniprot

SIRT-1
type: Protein
entity reference: SIRT-1
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

Paired amphipathic helix protein Sin3a
type: ProteinReference
xref: uniprot Q96ST3 168
xref: PTHR12346:SF2
organism: Homo sapiens

uniprot F7EEK4 337
type: UnificationXref
id: F7EEK4
db: uniprot

uniprot F1MYJ4 276
type: UnificationXref
id: F1MYJ4
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PAI-RIGHT__PAI-_re102
control type: ACTIVATION
controller: p53

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: uniprot A0A2I3TN41 95
xref: PTHR24356:SF163
organism: Pan troglodytes

Tetraspanin
type: DnaReference
xref: PTHR19282:SF44
organism: Pan troglodytes

PiP3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7FM29 112
type: UnificationXref
id: F7FM29
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re3
controller: Akt

PTHR12081:SF44
type: RelationshipXref
id: PTHR12081:SF44
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__p53-_Mdm2-RIGHT__Complex__Mdm2_p53_-_re59
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re59 541
participant stoichiometry: PARTICIPANT STOICHIOMETRY re59 540
participant stoichiometry: PARTICIPANT STOICHIOMETRY re59 542
left: Mdm2
left: p53
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Mdm2/p53)

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re5
controller: ATM/ATR

GADD45
type: Protein
entity reference: GADD45
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa171 443
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3T7A8 348
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

TRANSCRIPTION_LEFT__Apaf-RIGHT__Apaf-_re90
type: TemplateReaction
product: Apaf
xref: TRANSCRIPTION
participant: Apaf
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

ZMAT3 isoform 1
type: DnaReference
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Pan troglodytes

Adhesion G protein-coupled receptor B3
type: DnaReference
organism: Bos taurus

ncbitaxon 6945 310
type: UnificationXref
id: 6945
db: ncbitaxon

p110alpha
type: DnaRegion
entity reference: p110alpha
comment: SPECIES_TYPE=GENE

Scotin
type: RnaRegion
comment: SPECIES_TYPE=RNA

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q6P365 333
xref: PTHR45619:SF42
organism: Xenopus tropicalis

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 520
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 521
left: p53
interaction type: STATE_TRANSITION
right: p53

Protein Mdm4
type: ProteinReference
xref: uniprot Q5XIN1 231
organism: Rattus norvegicus

uniprot D4AA88 132
type: UnificationXref
id: D4AA88
db: uniprot

STATE_TRANSITION_LEFT__p53-RIGHT__a7_degraded-_re1
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 529
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 528
left: p53
interaction type: STATE_TRANSITION
right: a7_degraded

uniprot A0A2I3TSQ1 111
type: UnificationXref
id: A0A2I3TSQ1
db: uniprot

uniprot Q02099 79
type: UnificationXref
id: Q02099
db: uniprot

PTHR24356:SF368
type: RelationshipXref
id: PTHR24356:SF368
db: PANTHER Family
relationship type: By Homology

uniprot Q5ZHQ1 396
type: UnificationXref
id: Q5ZHQ1
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__IGF_BP3-RIGHT__IGF_BP3-_re96
control type: ACTIVATION
controller: p53

uniprot E1BX21 160
type: UnificationXref
id: E1BX21
db: uniprot

uniprot P13863 366
type: UnificationXref
id: P13863
db: uniprot

uniprot F7FN64 137
type: UnificationXref
id: F7FN64
db: uniprot

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot O42354 228
organism: Danio rerio

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot E7EXT6 275
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RJ75 380
organism: Macaca mulatta

uniprot P24864 17
type: UnificationXref
id: P24864
db: uniprot

PARTICIPANT STOICHIOMETRY re62 533
type: Stoichiometry
physical entity: a167_degraded
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__ARF-RIGHT__ARF-_re73
type: TemplateReaction
product: ARF
xref: TRANSCRIPTION
participant: ARF
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re62 532
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7DUD6 352
organism: Ornithorhynchus anatinus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot H2QRH7 320
organism: Pan troglodytes

uniprot E2R655 88
type: UnificationXref
id: E2R655
db: uniprot

Cyclin-dependent kinase 4 inhibitor D
type: ProteinReference
xref: uniprot P55273 408
organism: Homo sapiens

TRANSCRIPTION_LEFT__PML-RIGHT__PML-_re88
type: TemplateReaction
product: PML
xref: TRANSCRIPTION
participant: PML
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6QP11 280
xref: PTHR24356:SF171
organism: Monodelphis domestica

uniprot P60484 200
type: UnificationXref
id: P60484
db: uniprot

Mdm2 s30 sa173 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

P21
type: Protein
entity reference: P21
comment: SPECIES_TYPE=PROTEIN

Growth arrest and DNA damage-inducible protein GADD45 gamma
type: DnaReference
xref: PTHR10411:SF4
organism: Rattus norvegicus

uniprot F7FH21 212
type: UnificationXref
id: F7FH21
db: uniprot

uniprot Q00987 230
type: UnificationXref
id: Q00987
db: uniprot

uniprot W4XW48 238
type: UnificationXref
id: W4XW48
db: uniprot

High mobility group protein B1
type: ProteinReference
xref: uniprot P09429 124
organism: Homo sapiens

Wip1
type: DnaRegion
comment: SPECIES_TYPE=GENE

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P79734 148
xref: PTHR11447:SF6
organism: Danio rerio

PTHR10625:SF188
type: RelationshipXref
id: PTHR10625:SF188
db: PANTHER Family
relationship type: By Homology

Tumor protein 63
type: DnaReference
xref: PTHR11447:SF8
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: BAX

uniprot Q9VXG8 84
type: UnificationXref
id: Q9VXG8
db: uniprot

Cellular tumor antigen p53
type: DnaReference
xref: PTHR11447:SF6
organism: Bos taurus

uniprot P48316 253
type: UnificationXref
id: P48316
db: uniprot

PTHR10625:SF203
type: RelationshipXref
id: PTHR10625:SF203
db: PANTHER Family
relationship type: By Homology

Histone acetyltransferase KAT6B
type: ProteinReference
xref: uniprot Q8WYB5 182
xref: PTHR10615:SF73
organism: Homo sapiens

P110alpha s18 sa161 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: P110alpha
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR21584:SF10
xref: uniprot F7HGK9 48
organism: Macaca mulatta

P53AIP1
type: RnaRegion
comment: SPECIES_TYPE=RNA

uniprot E2RJX4 274
type: UnificationXref
id: E2RJX4
db: uniprot

G01568
type: UnificationXref
id: G01568
db: PANTHER Pathway Component

G01565
type: UnificationXref
id: G01565
db: PANTHER Pathway Component

G01566
type: UnificationXref
id: G01566
db: PANTHER Pathway Component

p53
type: Protein
entity reference: p53
feature: ser, thr p53 s16 sa141 rs2
feature: lys p53 s16 sa141 rs1
comment: SPECIES_TYPE=PROTEIN

G01569
type: UnificationXref
id: G01569
db: PANTHER Pathway Component

PTHR46874:SF1
type: RelationshipXref
id: PTHR46874:SF1
db: PANTHER Family
relationship type: By Homology

ncbitaxon 45351 306
type: UnificationXref
id: 45351
db: ncbitaxon

Plasminogen activator inhibitor 1
type: DnaReference
xref: PTHR11461:SF49
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot D3ZGW6 121
organism: Rattus norvegicus

Cyclin dependent kinase 1
type: ProteinReference
xref: uniprot E2RGJ9 358
organism: Canis lupus familiaris

High mobility group protein B1
type: ProteinReference
xref: uniprot Q6YKA4 128
organism: Canis lupus familiaris

uniprot F7FJQ1 39
type: UnificationXref
id: F7FJQ1
db: uniprot

PARTICIPANT STOICHIOMETRY re20 498
type: Stoichiometry
physical entity: PiP2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 497
type: Stoichiometry
physical entity: PiP3
stoichiometric coefficient: 1.0

G01571
type: UnificationXref
id: G01571
db: PANTHER Pathway Component

MODULATION
type: RelationshipTypeVocabulary

G01572
type: UnificationXref
id: G01572
db: PANTHER Pathway Component

Protein Mdm4
type: ProteinReference
xref: uniprot H2R875 224
organism: Pan troglodytes

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__p110alpha-RIGHT__p110alpha-_re71
control type: INHIBITION
controller: p53

G01574
type: UnificationXref
id: G01574
db: PANTHER Pathway Component

Cdk2
type: Protein
entity reference: Cdk2
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa167 435
comment: SPECIES_TYPE=PROTEIN

G01575
type: UnificationXref
id: G01575
db: PANTHER Pathway Component

G01576
type: UnificationXref
id: G01576
db: PANTHER Pathway Component

Metastasis-associated protein MTA2
type: ProteinReference
xref: PTHR10865:SF4
xref: uniprot O94776 92
organism: Homo sapiens

G01579
type: UnificationXref
id: G01579
db: PANTHER Pathway Component

00696
type: UnificationXref
id: MOD:00696
db: mod

TSP1
type: DnaRegion
entity reference: Thrombospondin-1
comment: SPECIES_TYPE=GENE

SIN3 homolog A, transcription regulator
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot H2R491 166
organism: Pan troglodytes

Sin3
type: Protein
entity reference: Sin3
comment: SPECIES_TYPE=PROTEIN

Apoptosis
type: Pathway

uniprot F6SSE6 243
type: UnificationXref
id: F6SSE6
db: uniprot

Tumor protein p53
type: DnaRegionReference
member entity reference: Tumor protein 63
member entity reference: Tumor protein p73
member entity reference: Tumor protein 63 (p63)
member entity reference: Cellular tumor antigen p53
xref: G04702
comment: ENTITY_REFERENCE_NOTES=Long Name: p53 Synonym: Synonym not specified Accession: G04702
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.p53
display name: p53

14-3-3
type: ProteinReference
xref: P04628
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.14-3-3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: 14-3-3 Synonym: Synonym not specified Accession: P04628
member entity reference: Stratifin
member entity reference: 14-3-3 protein sigma
member entity reference: SFN isoform 1
member entity reference: Similar to 14-3-3 protein sigma

ser, thr p53 s31 sa174 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY ser, thr
feature location: ser, thr p53 s31 sa174 rs2 ser, thr
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.7773911668162987
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=ser, thr

P21
type: ProteinReference
xref: P04631
standard name: Cyclin-dependent kinase inhibitor 1A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.P21
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclin-dependent kinase inhibitor 1A Synonym: CDK-interacting protein 1,CDKN1A,CIP1,Waf1,Wildteype p53-activated fragment 1,p21 Accession: P04631
member entity reference: Cyclin-dependent kinase inhibitor 1A
member entity reference: Cyclin-dependent kinase inhibitor 1
member entity reference: Cyclin dependent kinase inhibitor 1A

uniprot Q9LG11 188
type: UnificationXref
id: Q9LG11
db: uniprot

Apoptotic protease-activating factor 1
type: DnaReference
xref: PTHR22845:SF5
organism: Macaca mulatta

UNKNOWN_TRANSITION_LEFT__Senescence-RIGHT__Aging-_re64
type: Interaction
xref: UNKNOWN TRANSITION
participant: Senescence
participant: Aging

uniprot H2QC53 139
type: UnificationXref
id: H2QC53
db: uniprot

G01581
type: UnificationXref
id: G01581
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re11 519
type: Stoichiometry
physical entity: Chk2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 518
type: Stoichiometry
physical entity: Chk2
stoichiometric coefficient: 1.0

G01580
type: UnificationXref
id: G01580
db: PANTHER Pathway Component

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__ATM_ATR-RIGHT__ATM_ATR-_re4
controller: DNA Damage Stress Telomere shortening UV

Small ubiquitin-related modifier 3-like
type: ProteinReference
xref: uniprot Q6NV25 402
organism: Danio rerio

TRANSCRIPTION_LEFT__IGF_BP3-RIGHT__IGF_BP3-_re96
type: TemplateReaction
product: IGF-BP3
xref: TRANSCRIPTION
participant: IGF-BP3
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

GADD45B isoform 2
type: DnaReference
xref: PTHR10411:SF5
organism: Pan troglodytes

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7H808 318
xref: PTHR45619:SF42
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

Cyclin-dependent kinase 2
type: ProteinReference
xref: uniprot P23573 367
organism: Drosophila melanogaster

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Feedback loops
controller: Wip 1

Serine-protein kinase ATM
type: ProteinReference
xref: PTHR11139:SF72
xref: uniprot Q13315 80
organism: Homo sapiens

ncbitaxon 7668 25
type: UnificationXref
id: 7668
db: ncbitaxon

Cyclin E s24 sa168 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cyclin E
stoichiometric coefficient: 1.0

eco ECO:0000353 18
type: UnificationXref
id: ECO:0000353
db: eco

KILLER/DR5
type: DnaRegion
entity reference: KILLER/death receptor (DR)5
comment: SPECIES_TYPE=GENE

P110alpha
type: Protein
entity reference: P110alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa161 415
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

Small ubiquitin-related modifier 1
type: ProteinReference
xref: uniprot Q5I0H3 394
organism: Rattus norvegicus

Protein PML isoform 1
type: DnaReference
xref: PTHR25462:SF241
organism: Macaca mulatta

Cdc2
type: Protein
entity reference: Cdc2
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa165 427
comment: SPECIES_TYPE=PROTEIN

HMG1
type: Protein
entity reference: HMG1
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7227 57
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot F6Z5R3 37
type: UnificationXref
id: F6Z5R3
db: uniprot

Small ubiquitin-related modifier 3
type: ProteinReference
xref: uniprot Q6DK72 401
organism: Xenopus tropicalis

uniprot F7HT00 72
type: UnificationXref
id: F7HT00
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F7DUR2 136
organism: Ornithorhynchus anatinus

uniprot Q0VC36 269
type: UnificationXref
id: Q0VC36
db: uniprot

Cyclin-dependent kinase A-2
type: ProteinReference
xref: uniprot P29619 368
organism: Oryza sativa

GADD45
type: Protein
entity reference: GADD45
comment: SPECIES_TYPE=PROTEIN

uniprot F1Q3M8 349
type: UnificationXref
id: F1Q3M8
db: uniprot

PTHR10625:SF132
type: RelationshipXref
id: PTHR10625:SF132
db: PANTHER Family
relationship type: By Homology

uniprot A0A0B4KG70 85
type: UnificationXref
id: A0A0B4KG70
db: uniprot

uniprot P67774 328
type: UnificationXref
id: P67774
db: uniprot

Cyclin-dependent kinase 1
type: ProteinReference
xref: uniprot P39951 369
organism: Rattus norvegicus

M-phase inducer phosphatase 3
type: ProteinReference
xref: PTHR10828:SF64
xref: uniprot P30307 214
organism: Homo sapiens

S T Mdm2 s30 sa173 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s30 sa173 rs3 S T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6758332776215386

Uncharacterized protein
type: ProteinReference
xref: uniprot M0R7R5 123
organism: Rattus norvegicus

G-2 and S-phase expressed 1
type: DnaReference
xref: PTHR21584:SF10
organism: Pan troglodytes

DDB2 isoform 1
type: DnaReference
xref: PTHR15169:SF0
organism: Pan troglodytes

uniprot H2R4E1 213
type: UnificationXref
id: H2R4E1
db: uniprot

TRAF
type: Protein
entity reference: TRAF
comment: SPECIES_TYPE=PROTEIN

G1/S-specific cyclin-E1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot P39949 19
organism: Rattus norvegicus

uniprot P61075 371
type: UnificationXref
id: P61075
db: uniprot

uniprot P79734 148
type: UnificationXref
id: P79734
db: uniprot

ncbitaxon 7165 295
type: UnificationXref
id: 7165
db: ncbitaxon

S T Mdm2 s30 sa173 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s30 sa173 rs2 S T
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.618441538509672

STATE_TRANSITION_LEFT__WRN-RIGHT__WRN-_re117
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re117 471
participant stoichiometry: PARTICIPANT STOICHIOMETRY re117 472
left: WRN
interaction type: STATE_TRANSITION
right: WRN

uniprot B0S576 131
type: UnificationXref
id: B0S576
db: uniprot

uniprot P63159 127
type: UnificationXref
id: P63159
db: uniprot

uniprot Q64315 341
type: UnificationXref
id: Q64315
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q2U4X3 273
xref: PTHR24356:SF171
organism: Gallus gallus

uniprot Q5E9A5 256
type: UnificationXref
id: Q5E9A5
db: uniprot

uniprot Q5U3Z2 257
type: UnificationXref
id: Q5U3Z2
db: uniprot

Small ubiquitin-related modifier 3
type: ProteinReference
xref: uniprot Q5XIF4 395
organism: Rattus norvegicus

Cyclin B
type: ProteinReference
xref: P04614
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclin B Synonym: Synonym not specified Accession: P04614
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.Cyclin B
member entity reference: G2/mitotic-specific cyclin-B1
member entity reference: CCNB1 isoform 1
member entity reference: G2/mitotic-specific cyclin-B
member entity reference: Uncharacterized protein
member entity reference: Cyclin B1

Plasminogen activator inhibitor 1
type: DnaRegionReference
member entity reference: Plasminogen activator inhibitor 1
member entity reference: SERPINE1 isoform 1
member entity reference: Serpin family E member 1
member entity reference: Uncharacterized protein
xref: G04700
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.PAI
comment: ENTITY_REFERENCE_NOTES=Long Name: Plasminogen activator inhibitor 1 Synonym: Serpine 1 Accession: G04700
display name: PAI

Serine/threonine-protein kinase Chk2
type: ProteinReference
xref: uniprot Q9Z265 210
xref: PTHR44167:SF9
organism: Mus musculus

uniprot E2R3S2 52
type: UnificationXref
id: E2R3S2
db: uniprot

P300
type: ProteinReference
xref: P04611
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.P300
comment: ENTITY_REFERENCE_NOTES=Long Name: P300 Synonym: E1A-binding protein, 300-kD,EP300 Accession: P04611
member entity reference: E1A binding protein p300
member entity reference: Histone acetyltransferase p300
member entity reference: Uncharacterized protein

TRANSLATION_LEFT__GADD45-RIGHT__GADD45-_re82
type: TemplateReaction
product: GADD45
xref: TRANSLATION
participant: GADD45
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

CREB binding protein
type: ProteinReference
xref: uniprot F1PY87 171
xref: PTHR13808:SF34
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re121 460
type: Stoichiometry
physical entity: Sin3
stoichiometric coefficient: 1.0

Thrombospondin-1
type: DnaReference
xref: PTHR10199:SF78
organism: Homo sapiens

STATE_TRANSITION_LEFT__PiP3-RIGHT__PiP2-_re20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 497
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 498
left: PiP3
interaction type: STATE_TRANSITION
right: PiP2

uniprot H2QRH7 320
type: UnificationXref
id: H2QRH7
db: uniprot

PARTICIPANT STOICHIOMETRY re22 492
type: Stoichiometry
physical entity: PDK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 493
type: Stoichiometry
physical entity: PDK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re121 461
type: Stoichiometry
physical entity: Sin3
stoichiometric coefficient: 1.0

TNF receptor-associated factor 2
type: ProteinReference
xref: PTHR10131:SF21
xref: uniprot Q12933 157
organism: Homo sapiens

Tumor protein 63 (p63)
type: DnaReference
xref: PTHR11447:SF8
organism: Ornithorhynchus anatinus

PTHR12081:SF18
type: RelationshipXref
id: PTHR12081:SF18
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K5T3 347
organism: Rattus norvegicus

PTHR21584:SF10
type: RelationshipXref
id: PTHR21584:SF10
db: PANTHER Family
relationship type: By Homology

SERPINB5 isoform 1
type: DnaReference
xref: PTHR11461:SF55
organism: Pan troglodytes

P01480
type: UnificationXref
id: P01480
db: PANTHER Pathway Component

P01481
type: UnificationXref
id: P01481
db: PANTHER Pathway Component

P01482
type: UnificationXref
id: P01482
db: PANTHER Pathway Component

P01483
type: UnificationXref
id: P01483
db: PANTHER Pathway Component

P01484
type: UnificationXref
id: P01484
db: PANTHER Pathway Component

P01485
type: UnificationXref
id: P01485
db: PANTHER Pathway Component

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6U7A6 314
xref: PTHR45619:SF42
organism: Monodelphis domestica

P01486
type: UnificationXref
id: P01486
db: PANTHER Pathway Component

Cyclin-dependent kinase 2
type: ProteinReference
xref: PTHR24056:SF254
xref: uniprot Q7ZWB1 237
organism: Danio rerio

uniprot D3ZVU7 34
type: UnificationXref
id: D3ZVU7
db: uniprot

uniprot O96017 208
type: UnificationXref
id: O96017
db: uniprot

uniprot F1R8Z0 242
type: UnificationXref
id: F1R8Z0
db: uniprot

PARTICIPANT STOICHIOMETRY re15 509
type: Stoichiometry
physical entity: Sin3
stoichiometric coefficient: 1.0

uniprot F6X958 315
type: UnificationXref
id: F6X958
db: uniprot

CDK1 isoform 1
type: ProteinReference
xref: uniprot H2R7P8 362
organism: Pan troglodytes

BAX
type: RnaRegion
comment: SPECIES_TYPE=RNA

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot Q567Y8 331
organism: Danio rerio

ADGRB3 isoform 1
type: DnaReference
organism: Pan troglodytes

PTHR11085:SF15
type: RelationshipXref
id: PTHR11085:SF15
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__p53-RIGHT__p53-_re65
control type: ACTIVATION
controller: PCAF

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PUMA-RIGHT__PUMA-_re95
control type: ACTIVATION
controller: p53

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F7GEK1 284
organism: Monodelphis domestica

E3 ubiquitin-protein ligase
type: DnaReference
xref: PTHR45877:SF1
organism: Bos taurus

HETERODIMER_ASSOCIATION_LEFT__P110alpha-_PI3_K-RIGHT__Complex__P110alpha_PI3_K_-_re21
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 495
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 494
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 496
left: PI3-K
left: P110alpha
interaction type: HETERODIMER_ASSOCIATION
right: Complex (P110alpha/PI3-K)

ser, thr p53 s1 sa14 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY ser, thr
feature location: ser, thr p53 s1 sa14 rs2 ser, thr
comment: MODIFICATION_RESIDUE_ANGLE=3.7773911668162987
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=ser, thr

Cellular tumor antigen p53
type: DnaReference
xref: PTHR11447:SF6
organism: Mus musculus

PAG608
type: DnaRegion
entity reference: Wildtype p53-induced gene
comment: SPECIES_TYPE=GENE

PTHR12305:SF81
type: RelationshipXref
id: PTHR12305:SF81
db: PANTHER Family
relationship type: By Homology

DNA damage-binding protein 2
type: DnaReference
xref: PTHR15169:SF0
organism: Homo sapiens

CREB-binding protein
type: ProteinReference
xref: uniprot F6UDV6 173
xref: PTHR13808:SF34
organism: Xenopus tropicalis

uniprot H2QNY5 140
type: UnificationXref
id: H2QNY5
db: uniprot

HDAC1
type: ProteinReference
xref: P04612
standard name: Histon deacetylase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Histon deacetylase 1 Synonym: HD1,RPD3-like Accession: P04612
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.HDAC1
member entity reference: Histone deacetylase 1
member entity reference: Histone deacetylase

uniprot F6TMI7 381
type: UnificationXref
id: F6TMI7
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__TRAF-RIGHT__TRAF-_re123
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

uniprot P48734 370
type: UnificationXref
id: P48734
db: uniprot

uniprot F7GA51 138
type: UnificationXref
id: F7GA51
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4XFP6 379
organism: Strongylocentrotus purpuratus

PTHR14399:SF4
type: RelationshipXref
id: PTHR14399:SF4
db: PANTHER Family
relationship type: By Homology

uniprot F7DUR2 136
type: UnificationXref
id: F7DUR2
db: uniprot

ATR serine/threonine kinase
type: ProteinReference
xref: PTHR11139:SF69
xref: uniprot F7DU67 71
organism: Xenopus tropicalis

uniprot P45481 180
type: UnificationXref
id: P45481
db: uniprot

Cyclin dependent kinase 2
type: ProteinReference
xref: uniprot E2QW70 234
xref: PTHR24056:SF254
organism: Canis lupus familiaris

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot Q00987 230
organism: Homo sapiens

M-phase inducer phosphatase 3
type: ProteinReference
xref: PTHR10828:SF64
xref: uniprot P48967 217
organism: Mus musculus

M-phase inducer phosphatase 1
type: ProteinReference
xref: uniprot P48964 215
xref: PTHR10828:SF46
organism: Mus musculus

M-phase inducer phosphatase 1
type: ProteinReference
xref: PTHR10828:SF46
xref: uniprot P48965 216
organism: Rattus norvegicus

TRANSLATION_LEFT__ARF-RIGHT__ARF-_re74
type: TemplateReaction
product: ARF
xref: TRANSLATION
participant: ARF
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

BAL1
type: DnaRegion
comment: SPECIES_TYPE=GENE

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Monodelphis domestica

DNA Damage Stress Telomere shortening UV
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

lys p53 s16 sa141 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys p53 s16 sa141 rs1 lys
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=lys
comment: MODIFICATION_RESIDUE_ANGLE=0.0

uniprot P39689 340
type: UnificationXref
id: P39689
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR10199:SF78
organism: Macaca mulatta

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

FAS
type: RnaRegion
comment: SPECIES_TYPE=RNA

Plasminogen activator inhibitor 1
type: DnaReference
xref: PTHR11461:SF49
organism: Mus musculus

uniprot Q9Y7J6 109
type: UnificationXref
id: Q9Y7J6
db: uniprot

uniprot F7EBI6 244
type: UnificationXref
id: F7EBI6
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__R2-RIGHT__R2-_re105
control type: ACTIVATION
controller: p53

ARF
type: Protein
entity reference: ARF
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

uniprot O70456 267
type: UnificationXref
id: O70456
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P48463 322
xref: PTHR45619:SF44
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PiP2-RIGHT__PiP3-_re19
controller: Complex (P110alpha/PI3-K)

Uncharacterized protein
type: ProteinReference
xref: PTHR10177:SF193
xref: uniprot E2R3S2 52
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GRY6 361
organism: Macaca mulatta

Protein Mdm4
type: ProteinReference
xref: uniprot F1N736 222
organism: Bos taurus

Thrombospondin-1
type: DnaReference
xref: PTHR10199:SF78
organism: Bos taurus

uniprot E2RDT3 220
type: UnificationXref
id: E2RDT3
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 38

Akt s11 sa10 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.07
comment: MODIFICATION_RESIDUE_NAME=

uniprot P63330 326
type: UnificationXref
id: P63330
db: uniprot

uniprot E9QG65 133
type: UnificationXref
id: E9QG65
db: uniprot

Cyclin G
type: RnaRegion
comment: SPECIES_TYPE=RNA

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: G2-M
controller: Complex (Cdc25C/Cyclin B/ Cdc2)

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__KILLER_DR5-RIGHT__KILLER_DRS-_re87
control type: ACTIVATION
controller: p53

Mdm2
type: Protein
entity reference: Mdm2
feature: ACTIVE 11
feature: S T Mdm2 s141 sa100 rs2
feature: Mdm2 s141 sa100 rs1
feature: S T Mdm2 s141 sa100 rs3
comment: SPECIES_TYPE=PROTEIN

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot O15530 97
xref: PTHR24356:SF163
organism: Homo sapiens

GADD45A isoform 1
type: ProteinReference
xref: PTHR10411:SF3
xref: uniprot H2R902 248
organism: Pan troglodytes

Chk2 s41 sa23 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot C3XQF4 311
type: UnificationXref
id: C3XQF4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Chk2-RIGHT__Chk2-_re12
controller: ATM/ATR

uniprot F1NQ71 13
type: UnificationXref
id: F1NQ71
db: uniprot

Histone deacetylase
type: ProteinReference
xref: uniprot A0A0D1E0Y7 31
xref: PTHR10625:SF132
organism: Ustilago maydis

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7G3I5 353
xref: PTHR10048:SF107
organism: Monodelphis domestica

Paired amphipathic helix protein Sin3a
type: ProteinReference
xref: uniprot F7H3V1 165
xref: PTHR12346:SF2
organism: Macaca mulatta

uniprot F7BEI4 16
type: UnificationXref
id: F7BEI4
db: uniprot

PUMA
type: RnaRegion
comment: SPECIES_TYPE=RNA

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__Cdc2-_Cdc25C-_Cyclin_B-RIGHT__Complex__Cdc25C_Cyclin_B__Cdc2_-_re29
control type: INHIBITION
controller: 14-3-3

Serpin B5
type: DnaReference
xref: PTHR11461:SF55
organism: Homo sapiens

Cyclin-dependent kinase inhibitor 1A
type: DnaReference
xref: PTHR46778:SF1
organism: Rattus norvegicus

uniprot Q9YH06 129
type: UnificationXref
id: Q9YH06
db: uniprot

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

uniprot W4ZAK5 336
type: UnificationXref
id: W4ZAK5
db: uniprot

ncbitaxon 10228 308
type: UnificationXref
id: 10228
db: ncbitaxon

P300
type: Protein
entity reference: P300
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

Mdm2
type: Protein
entity reference: Mdm2
feature: S T Mdm2 s84 sa11 rs2
feature: Mdm2 s84 sa11 rs1
feature: S T Mdm2 s84 sa11 rs3
comment: SPECIES_TYPE=PROTEIN

Similar to 14-3-3 protein sigma
type: DnaReference
xref: PTHR18860:SF14
organism: Rattus norvegicus

GH01161p
type: ProteinReference
xref: uniprot Q9W3I9 158
organism: Drosophila melanogaster

uniprot B2GV01 87
type: UnificationXref
id: B2GV01
db: uniprot

G-2 and S-phase expressed 1
type: ProteinReference
xref: PTHR21584:SF10
xref: uniprot A0A2I3T8F5 47
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re21 495
type: Stoichiometry
physical entity: PI3-K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 496
type: Stoichiometry
physical entity: Complex (P110alpha/PI3-K)
stoichiometric coefficient: 1.0

Cdk2
type: Protein
entity reference: Cdk2
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa169 419
comment: SPECIES_TYPE=PROTEIN

uniprot P23573 367
type: UnificationXref
id: P23573
db: uniprot

PARTICIPANT STOICHIOMETRY re18 502
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 108

PARTICIPANT STOICHIOMETRY re18 501
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1NH21 272
xref: PTHR24356:SF176
organism: Bos taurus

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot F7FN64 137
xref: PTHR11447:SF8
organism: Macaca mulatta

uniprot F6VW96 261
type: UnificationXref
id: F6VW96
db: uniprot

uniprot P38111 78
type: UnificationXref
id: P38111
db: uniprot

Growth arrest and DNA damage-inducible protein GADD45 gamma
type: ProteinReference
xref: PTHR10411:SF4
xref: uniprot O95257 250
organism: Homo sapiens

Cyclin dependent kinase 2
type: ProteinReference
xref: uniprot A0A2I3RR15 233
xref: PTHR24056:SF254
organism: Pan troglodytes

uniprot O15151 226
type: UnificationXref
id: O15151
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 22

p53 apoptosis effector related to PMP-22
type: DnaReference
xref: PTHR14399:SF4
organism: Homo sapiens

Serine/threonine-protein kinase PKH2
type: ProteinReference
xref: PTHR24356:SF368
xref: uniprot Q12236 101
organism: Saccharomyces cerevisiae

uniprot A7T2Q5 305
type: UnificationXref
id: A7T2Q5
db: uniprot

PARTICIPANT STOICHIOMETRY re21 494
type: Stoichiometry
physical entity: P110alpha
stoichiometric coefficient: 1.0

uniprot P10103 125
type: UnificationXref
id: P10103
db: uniprot

PTHR25462:SF241
type: RelationshipXref
id: PTHR25462:SF241
db: PANTHER Family
relationship type: By Homology

Serpin B5
type: DnaReference
xref: PTHR11461:SF55
organism: Rattus norvegicus

p53
type: RnaRegion
comment: SPECIES_TYPE=RNA

Mdm2
type: Protein
entity reference: Mdm2
feature: S T Mdm2 s85 sa62 rs2
feature: S T Mdm2 s85 sa62 rs3
feature: Mdm2 s85 sa62 rs1
comment: SPECIES_TYPE=PROTEIN

S T Mdm2 s142 sa101 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s142 sa101 rs3 S T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6758332776215386

phospatase and tensin homologue
type: DnaRegionReference
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
member entity reference: IP16020p
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
member entity reference: Putative tyrosine-protein phosphatase TPTE
member entity reference: MCG118205, isoform CRA_c
xref: G01579
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.PTEN
comment: ENTITY_REFERENCE_NOTES=Long Name: PTEN Synonym: Synonym not specified Accession: G01579
display name: PTEN

uniprot Q9Z172 404
type: UnificationXref
id: Q9Z172
db: uniprot

Cyclin-dependent kinase 1
type: ProteinReference
xref: uniprot P06493 364
organism: Homo sapiens

Cyclin-dependent kinase inhibitor 2A
type: ProteinReference
xref: PTHR24201:SF4
xref: uniprot P42771 407
organism: Homo sapiens

E3 ubiquitin-protein ligase Siah1
type: DnaReference
xref: PTHR45877:SF1
organism: Danio rerio

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 32

uniprot Q6DIJ3 258
type: UnificationXref
id: Q6DIJ3
db: uniprot

uniprot P62714 323
type: UnificationXref
id: P62714
db: uniprot

S T Mdm2 s142 sa101 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s142 sa101 rs2 S T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.618441538509672

uniprot P48317 254
type: UnificationXref
id: P48317
db: uniprot

ncbitaxon 44689 61
type: UnificationXref
id: 44689
db: ncbitaxon

S T Mdm2 s84 sa11 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s84 sa11 rs2 S T
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.618441538509672

PIGs
type: DnaRegion
comment: SPECIES_TYPE=GENE

uniprot Q6NV25 402
type: UnificationXref
id: Q6NV25
db: uniprot

Serine-protein kinase ATM
type: ProteinReference
xref: uniprot D4ACL8 67
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6XP81 283
organism: Xenopus tropicalis

G1-S
type: Pathway

Damage-specific DNA-binding protein 2
type: DnaReference
organism: Rattus norvegicus

Cyclin-dependent kinase inhibitor 1
type: DnaReference
organism: Macaca mulatta

uniprot P04637 144
type: UnificationXref
id: P04637
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10865:SF4
xref: uniprot F7ECL6 91
organism: Monodelphis domestica

S T Mdm2 s84 sa11 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s84 sa11 rs3 S T
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6758332776215386

uniprot P55273 408
type: UnificationXref
id: P55273
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4XW48 238
organism: Strongylocentrotus purpuratus

Uncharacterized protein
type: DnaReference
organism: Macaca mulatta

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: FAS

Thrombospondin 1
type: DnaReference
xref: PTHR10199:SF78
organism: Canis lupus familiaris

GADD45
type: DnaRegion
entity reference: Growth arrest and DNA-damage-inducible, alpha
comment: SPECIES_TYPE=GENE

uniprot Q5ZJM9 397
type: UnificationXref
id: Q5ZJM9
db: uniprot

STATE_TRANSITION_LEFT__Sumo_1_ligase-RIGHT__Sumo_1_ligase-_re116
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re116 473
participant stoichiometry: PARTICIPANT STOICHIOMETRY re116 474
left: Sumo-1 ligase
interaction type: STATE_TRANSITION
right: Sumo-1 ligase

Cyclin-G1
type: DnaReference
xref: PTHR10177:SF59
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Apaf-RIGHT__Apaf-_re90
control type: ACTIVATION
controller: p53

Histone acetyltransferase HAC12
type: ProteinReference
xref: PTHR13808:SF28
xref: uniprot Q9FWQ5 185
organism: Arabidopsis thaliana

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 9

uniprot Q9XF67 107
type: UnificationXref
id: Q9XF67
db: uniprot

Apoptosis-inducing factor, mitochondria-associated 2
type: DnaReference
organism: Rattus norvegicus

uniprot W4XFP6 379
type: UnificationXref
id: W4XFP6
db: uniprot

TRANSCRIPTION_LEFT__NOXA-RIGHT__NOXA-_re94
type: TemplateReaction
product: NOXA
xref: TRANSCRIPTION
participant: NOXA
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

TRANSCRIPTION_LEFT__KAI-RIGHT__KAI-_re111
type: TemplateReaction
product: KAI
xref: TRANSCRIPTION
participant: KAI
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Homo sapiens

Serine/threonine-protein phosphatase PP2A
type: ProteinReference
xref: uniprot P23696 321
xref: PTHR45619:SF12
organism: Drosophila melanogaster

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot Q9Z265 210
type: UnificationXref
id: Q9Z265
db: uniprot

INHIBITION
type: RelationshipTypeVocabulary

PTHR10411:SF3
type: RelationshipXref
id: PTHR10411:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q5E9Y0 236
type: UnificationXref
id: Q5E9Y0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SZM3 207
xref: PTHR44167:SF9
organism: Macaca mulatta

PTHR10411:SF4
type: RelationshipXref
id: PTHR10411:SF4
db: PANTHER Family
relationship type: By Homology

PTHR10411:SF5
type: RelationshipXref
id: PTHR10411:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q61457 23
type: UnificationXref
id: Q61457
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P02340 143
organism: Mus musculus

uniprot O88898 142
type: UnificationXref
id: O88898
db: uniprot

ATR isoform 1
type: ProteinReference
xref: PTHR11139:SF69
xref: uniprot K7DR10 73
organism: Pan troglodytes

Cyclin B s26 sa164 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cyclin B
stoichiometric coefficient: 1.0

uniprot Q5I0H3 394
type: UnificationXref
id: Q5I0H3
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
type: ProteinReference
xref: uniprot G5EE01 195
xref: PTHR12305:SF81
organism: Caenorhabditis elegans

Cell division cycle 25C
type: ProteinReference
xref: PTHR10828:SF64
xref: uniprot H2R4E1 213
organism: Pan troglodytes

Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Xenopus tropicalis

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__ARF-RIGHT__ARF-_re73
control type: ACTIVATION
controller: E2F-1

uniprot F6YU32 89
type: UnificationXref
id: F6YU32
db: uniprot

PARTICIPANT STOICHIOMETRY re119 467
type: Stoichiometry
physical entity: MTA2
stoichiometric coefficient: 1.0

uniprot P62715 324
type: UnificationXref
id: P62715
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: IGF-BP3

TRANSLATION_LEFT__PTEN-RIGHT__PTEN-_re70
type: TemplateReaction
product: PTEN
xref: TRANSLATION
participant: PTEN
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

ser, thr p53 s65 sa45 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY ser, thr
feature location: ser, thr p53 s65 sa45 rs2 ser, thr
comment: MODIFICATION_RESIDUE_ANGLE=3.7773911668162987
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=ser, thr

uniprot D3ZGW6 121
type: UnificationXref
id: D3ZGW6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF200
xref: uniprot G3X7B5 285
organism: Bos taurus

STATE_TRANSITION_LEFT__SIRT_1-RIGHT__SIRT_1-_re125
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re125 453
participant stoichiometry: PARTICIPANT STOICHIOMETRY re125 452
left: SIRT-1
interaction type: STATE_TRANSITION
right: SIRT-1

uniprot F6QP11 280
type: UnificationXref
id: F6QP11
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7CP86 316
xref: PTHR45619:SF44
organism: Monodelphis domestica

TNF receptor-associated factor 2
type: ProteinReference
xref: uniprot P39429 156
organism: Mus musculus

MTA2
type: Protein
entity reference: MTA2
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa156 431
comment: SPECIES_TYPE=PROTEIN

uniprot P22339 251
type: UnificationXref
id: P22339
db: uniprot

uniprot P62716 325
type: UnificationXref
id: P62716
db: uniprot

TRANSLATION_LEFT__14_3_3-RIGHT__14_3_3-_re78
type: TemplateReaction
product: 14-3-3
xref: TRANSLATION
participant: 14-3-3
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Complex (Cdk2/Cyclin E)
type: Complex
component stoichiometry: Cdk2 s20 sa169 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cyclin E s21 sa170 STOICHIOMETRY ID COMPLEX
component: Cdk2
component: Cyclin E
feature: COMPLEX BINDING FEATURE s96 csa7 420
feature: ACTIVE 11
feature: COMPLEX BINDING FEATURE s96 csa7 418

uniprot P42336 356
type: UnificationXref
id: P42336
db: uniprot

uniprot J9NUI0 41
type: UnificationXref
id: J9NUI0
db: uniprot

Apaf
type: DnaRegion
entity reference: Apoptotic protease activating factor 1
comment: SPECIES_TYPE=GENE

Tumor protein 63 (p63)
type: DnaReference
xref: PTHR11447:SF8
organism: Danio rerio

Uncharacterized protein
type: DnaReference
xref: PTHR10199:SF78
organism: Monodelphis domestica

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Inhibition of Angiogenesis and Metastasis
controller: BAL1

Growth arrest and DNA damage-inducible protein GADD45 beta
type: ProteinReference
xref: PTHR10411:SF5
xref: uniprot O75293 249
organism: Homo sapiens

uniprot Q60773 409
type: UnificationXref
id: Q60773
db: uniprot

uniprot B0V1J5 206
type: UnificationXref
id: B0V1J5
db: uniprot

ser, thr p53 s16 sa1 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY ser, thr
feature location: ser, thr p53 s16 sa1 rs2 ser, thr
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.7773911668162987
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=ser, thr

uniprot O15530 97
type: UnificationXref
id: O15530
db: uniprot

Thrombospondin-1
type: DnaRegionReference
member entity reference: Thrombospondin-1
member entity reference: Uncharacterized protein
member entity reference: Thrombospondin 1
xref: G01566
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.TSP1
comment: ENTITY_REFERENCE_NOTES=Long Name: Thrombospondin-1 Synonym: Synonym not specified Accession: G01566
display name: TSP1

ARF s14 sa159 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ARF
stoichiometric coefficient: 1.0

SIN3 transcription regulator family member A
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot F7B0D4 163
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY re119 468
type: Stoichiometry
physical entity: MTA2
stoichiometric coefficient: 1.0

ncbitaxon 10090 8
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot O15350 141
type: UnificationXref
id: O15350
db: uniprot

Mdm2
type: Protein
entity reference: Mdm2
feature: ACTIVE 11
feature: S T Mdm2 s142 sa101 rs3
feature: S T Mdm2 s142 sa101 rs2
feature: Mdm2 s142 sa101 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2J8LWA9 405
type: UnificationXref
id: A0A2J8LWA9
db: uniprot

uniprot F7GRY6 361
type: UnificationXref
id: F7GRY6
db: uniprot

p53 apoptosis effector related to PMP-22
type: DnaReference
organism: Mus musculus

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot H2QNY5 140
organism: Pan troglodytes

uniprot P24522 252
type: UnificationXref
id: P24522
db: uniprot

MDM2 proto-oncogene
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot A0A2I3RE00 219
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Maspin-RIGHT__Maspin-_re107
control type: ACTIVATION
controller: p53

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PIGs-RIGHT__PIGs-_re92
control type: ACTIVATION
controller: p53

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot W4ZAK5 336
organism: Strongylocentrotus purpuratus

PARTICIPANT STOICHIOMETRY re120 463
type: Stoichiometry
physical entity: HDAC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re120 462
type: Stoichiometry
physical entity: HDAC1
stoichiometric coefficient: 1.0

Protein PML
type: ProteinReference
xref: uniprot P29590 117
xref: PTHR25462:SF241
organism: Homo sapiens

uniprot Q9JJP6 152
type: UnificationXref
id: Q9JJP6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot F7BFR8 164
organism: Monodelphis domestica

CCNE1 isoform 1
type: ProteinReference
xref: uniprot A0A2I3TEU6 12
xref: PTHR10177:SF71
organism: Pan troglodytes

uniprot Q5EBB0 270
type: UnificationXref
id: Q5EBB0
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6RCU6 282
xref: PTHR24356:SF171
organism: Macaca mulatta

uniprot Q96EB6 345
type: UnificationXref
id: Q96EB6
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Feedback loops
controller: Cyclin G

FAS protein
type: DnaReference
xref: PTHR46874:SF1
organism: Bos taurus

uniprot F1Q4F8 278
type: UnificationXref
id: F1Q4F8
db: uniprot

PARTICIPANT STOICHIOMETRY re24 491
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 490
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__PUMA-RIGHT__PUMA-_re95
type: TemplateReaction
product: PUMA
xref: TRANSCRIPTION
participant: PUMA
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Complex (ARF/E2F-1)
type: Complex
component stoichiometry: ARF s14 sa159 STOICHIOMETRY ID COMPLEX
component stoichiometry: E2F 1 s17 sa160 STOICHIOMETRY ID COMPLEX
component: E2F-1
component: ARF
feature: COMPLEX BINDING FEATURE s73 csa3 410
feature: COMPLEX BINDING FEATURE s73 csa3 412

PARTICIPANT STOICHIOMETRY re14 513
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Histone deacetylase 1
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot P56517 44
organism: Gallus gallus

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: ProteinReference
xref: uniprot Q3ZBN6 255
xref: PTHR10411:SF3
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re14 512
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

S T Mdm2 s139 sa61 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s139 sa61 rs3 S T
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6758332776215386

Tumor protein p73
type: ProteinReference
xref: uniprot B0S576 131
xref: PTHR11447:SF21
organism: Danio rerio

uniprot F7GEK1 284
type: UnificationXref
id: F7GEK1
db: uniprot

TRANSLATION_LEFT__B99-RIGHT__B99-_re80
type: TemplateReaction
product: B99
xref: TRANSLATION
participant: B99
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot P39949 19
type: UnificationXref
id: P39949
db: uniprot

uniprot A0A0G2K5T3 347
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42336 356
xref: PTHR10048:SF107
organism: Homo sapiens

uniprot Q6DEP7 398
type: UnificationXref
id: Q6DEP7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 357
organism: Mus musculus

Cell division control protein 2
type: ProteinReference
xref: uniprot Q7T3L7 378
organism: Danio rerio

uniprot P31749 287
type: UnificationXref
id: P31749
db: uniprot

SIN3 transcription regulator family member A
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot F6TAI6 162
organism: Xenopus tropicalis

PTHR22845:SF5
type: RelationshipXref
id: PTHR22845:SF5
db: PANTHER Family
relationship type: By Homology

Small ubiquitin-related modifier 2
type: ProteinReference
xref: uniprot Q5ZJM9 397
organism: Gallus gallus

uniprot H2R875 224
type: UnificationXref
id: H2R875
db: uniprot

ncbitaxon 8364 36
type: UnificationXref
id: 8364
db: ncbitaxon

Cytokine-responsive protein CR6
type: ProteinReference
xref: uniprot F7GZG4 245
xref: PTHR10411:SF4
organism: Macaca mulatta

Cyclin-dependent kinase 1
type: ProteinReference
xref: uniprot P11440 365
organism: Mus musculus

Cyclin E
type: Protein
entity reference: Cyclin E
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa168 437
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: DnaReference
xref: PTHR10411:SF3
organism: Monodelphis domestica

p110alpha
type: RnaRegion
comment: SPECIES_TYPE=RNA

Growth arrest and DNA damage inducible gamma
type: ProteinReference
xref: uniprot E2RK27 241
xref: PTHR10411:SF4
organism: Canis lupus familiaris

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
type: ProteinReference
xref: uniprot Q9LT75 204
organism: Arabidopsis thaliana

Growth arrest and DNA damage inducible gamma
type: DnaReference
xref: PTHR10411:SF4
organism: Canis lupus familiaris

uniprot P56517 44
type: UnificationXref
id: P56517
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot P63331 327
organism: Rattus norvegicus

Insulin-like growth factor-binding protein 3
type: DnaReference
organism: Danio rerio

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot P63330 326
organism: Mus musculus

PI3-K
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa162 417
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

lys p53 s1 sa14 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys p53 s1 sa14 rs1 lys
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=lys
comment: MODIFICATION_RESIDUE_ANGLE=0.0

uniprot P48964 215
type: UnificationXref
id: P48964
db: uniprot

uniprot G3X7B5 285
type: UnificationXref
id: G3X7B5
db: uniprot

PTHR12011:SF39
type: RelationshipXref
id: PTHR12011:SF39
db: PANTHER Family
relationship type: By Homology

TRANSLATION
type: RelationshipTypeVocabulary

S T Mdm2 s85 sa62 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s85 sa62 rs2 S T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.618441538509672

uniprot Q6DI05 400
type: UnificationXref
id: Q6DI05
db: uniprot

G1/S-specific cyclin-E1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot F1NQ71 13
organism: Gallus gallus

uniprot F6WCW3 382
type: UnificationXref
id: F6WCW3
db: uniprot

TRANSCRIPTION_LEFT__p53-RIGHT__p53-_re65
type: TemplateReaction
product: p53
xref: TRANSCRIPTION
participant: p53
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

00394
type: UnificationXref
id: MOD:00394
db: mod

uniprot P67775 329
type: UnificationXref
id: P67775
db: uniprot

Adhesion G protein-coupled receptor B2
type: DnaReference
organism: Rattus norvegicus

ACTIVE 11
type: EntityFeature
comment: Active state

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__FAS-RIGHT__FAS-_re85
control type: ACTIVATION
controller: p53

Tumor protein 63 (p63)
type: DnaReference
xref: PTHR11447:SF8
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10828:SF64
xref: uniprot F7FH21 212
organism: Macaca mulatta

Uncharacterized protein
type: DnaReference
xref: PTHR11461:SF55
organism: Macaca mulatta

uniprot F1PL57 135
type: UnificationXref
id: F1PL57
db: uniprot

S T Mdm2 s85 sa62 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s85 sa62 rs3 S T
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6758332776215386

Cyclin-dependent kinase 2
type: ProteinReference
xref: uniprot P97377 373
xref: PTHR24056:SF254
organism: Mus musculus

Small ubiquitin-related modifier
type: ProteinReference
xref: uniprot F6TMI7 381
organism: Macaca mulatta

uniprot F7HGK9 48
type: UnificationXref
id: F7HGK9
db: uniprot

uniprot Q9WTQ7 259
type: UnificationXref
id: Q9WTQ7
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__Cdc2-_Cdc25C-_Cyclin_B-RIGHT__Complex__Cdc25C_Cyclin_B__Cdc2_-_re29
control type: INHIBITION
controller: Complex (GADD45/B99)

Serine-protein kinase ATM
type: ProteinReference
xref: PTHR11139:SF72
xref: uniprot E1BEI6 68
organism: Bos taurus

PTHR15169:SF0
type: RelationshipXref
id: PTHR15169:SF0
db: PANTHER Family
relationship type: By Homology

uniprot A0A452DI17 239
type: UnificationXref
id: A0A452DI17
db: uniprot

Growth arrest and DNA damage inducible beta
type: DnaReference
xref: PTHR10411:SF5
organism: Canis lupus familiaris

uniprot P56424 146
type: UnificationXref
id: P56424
db: uniprot

PARTICIPANT STOICHIOMETRY re29 481
type: Stoichiometry
physical entity: Cdc2
stoichiometric coefficient: 1.0

Stratifin
type: ProteinReference
xref: uniprot F7BU66 264
xref: PTHR18860:SF14
organism: Ornithorhynchus anatinus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PML-RIGHT__PML-_re88
control type: ACTIVATION
controller: p53

PARTICIPANT STOICHIOMETRY re29 483
type: Stoichiometry
physical entity: Cyclin B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 482
type: Stoichiometry
physical entity: Cdc25C
stoichiometric coefficient: 1.0

Stratifin
type: DnaReference
xref: PTHR18860:SF14
organism: Ornithorhynchus anatinus

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: ProteinReference
xref: uniprot P24522 252
xref: PTHR10411:SF3
organism: Homo sapiens

HDAC1
type: Protein
entity reference: HDAC1
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa155 429
comment: SPECIES_TYPE=PROTEIN

TRANSLATION_LEFT__PML-RIGHT__PML-_re89
type: TemplateReaction
product: PML
xref: TRANSLATION
participant: PML
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PARTICIPANT STOICHIOMETRY re29 484
type: Stoichiometry
physical entity: Complex (Cdc25C/Cyclin B/ Cdc2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re118 469
type: Stoichiometry
physical entity: P300
stoichiometric coefficient: 1.0

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot D3ZVU7 34
organism: Rattus norvegicus

uniprot F6ULG8 35
type: UnificationXref
id: F6ULG8
db: uniprot

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot F6ULG8 35
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY re13 515
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re118 470
type: Stoichiometry
physical entity: P300
stoichiometric coefficient: 1.0

p53
type: Protein
entity reference: p53
feature: ser, thr p53 s16 sa1 rs2
feature: ACTIVE 11
feature: lys p53 s16 sa1 rs1
comment: SPECIES_TYPE=PROTEIN

ser, thr p53 s16 sa141 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY ser, thr
feature location: ser, thr p53 s16 sa141 rs2 ser, thr
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.7773911668162987
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=ser, thr

S T Mdm2 s139 sa61 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s139 sa61 rs2 S T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.618441538509672

PARTICIPANT STOICHIOMETRY re13 514
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Survival
type: Pathway

uniprot F6SZM3 207
type: UnificationXref
id: F6SZM3
db: uniprot

IGFBP3 isoform 2
type: DnaReference
organism: Pan troglodytes

uniprot F6ZIB3 70
type: UnificationXref
id: F6ZIB3
db: uniprot

High-mobility group (nonhistone chromosomal) protein 1-like 1
type: ProteinReference
xref: uniprot A0A0G2K6P4 119
organism: Rattus norvegicus

uniprot D3ZIU9 122
type: UnificationXref
id: D3ZIU9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot E1BX21 160
organism: Gallus gallus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PIDD-RIGHT__PIDD-_re86
control type: ACTIVATION
controller: p53

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9Y243 299
organism: Homo sapiens

uniprot Q6JHU9 181
type: UnificationXref
id: Q6JHU9
db: uniprot

Serine/threonine-protein kinase Chk2
type: ProteinReference
xref: uniprot O96017 208
xref: PTHR44167:SF9
organism: Homo sapiens

NAD-dependent protein deacetylase sirtuin-1
type: ProteinReference
xref: uniprot Q923E4 344
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re18
controller: PP2A

STATE_TRANSITION_LEFT__HDAC1-RIGHT__HDAC1-_re120
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re120 463
participant stoichiometry: PARTICIPANT STOICHIOMETRY re120 462
left: HDAC1
interaction type: STATE_TRANSITION
right: HDAC1

uniprot Q6P365 333
type: UnificationXref
id: Q6P365
db: uniprot

BAX
type: DnaRegion
entity reference: BCL2-associated X protein
comment: SPECIES_TYPE=GENE

uniprot F6VBA7 193
type: UnificationXref
id: F6VBA7
db: uniprot

R2
type: RnaRegion
comment: SPECIES_TYPE=RNA

uniprot P39429 156
type: UnificationXref
id: P39429
db: uniprot

Plasminogen activator inhibitor 1
type: DnaReference
xref: PTHR11461:SF49
organism: Rattus norvegicus

B99
type: DnaRegion
entity reference: B99
comment: SPECIES_TYPE=GENE

14-3-3 protein sigma
type: ProteinReference
xref: uniprot P31947 268
xref: PTHR18860:SF14
organism: Homo sapiens

Sumo-1 ligase
type: Protein
entity reference: Sumo-1 ligase
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

ATM ATR s15 sa13 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Putative tyrosine-protein phosphatase TPTE
type: ProteinReference
xref: uniprot P56180 198
organism: Homo sapiens

UNKNOWN_TRANSITION
type: InteractionVocabulary

uniprot P31751 289
type: UnificationXref
id: P31751
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_re22
controller: PiP3

ncbitaxon 9913 3
type: UnificationXref
id: 9913
db: ncbitaxon

TRANSLATION
type: InteractionVocabulary

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 40

uniprot W4XEA0 24
type: UnificationXref
id: W4XEA0
db: uniprot

Tumor necrosis factor receptor superfamily member 6
type: DnaReference
xref: PTHR46874:SF1
organism: Macaca mulatta

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot P62715 324
organism: Mus musculus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62716 325
xref: PTHR45619:SF44
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62714 323
xref: PTHR45619:SF44
organism: Homo sapiens

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__GD_AIF-RIGHT__GD_AIF-_re110
control type: ACTIVATION
controller: p53

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
type: ProteinReference
xref: uniprot Q9FLZ5 203
organism: Arabidopsis thaliana

Sin3
type: Protein
entity reference: Sin3
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

Oncogenes
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q96ST3 168
type: UnificationXref
id: Q96ST3
db: uniprot

uniprot F7GX97 53
type: UnificationXref
id: F7GX97
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__TSP1-RIGHT__TSP1-_re108
control type: ACTIVATION
controller: p53

p53 s31 sa174 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

ncbitaxon 9606 6
type: UnificationXref
id: 9606
db: ncbitaxon

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Xenopus tropicalis

uniprot B3S653 307
type: UnificationXref
id: B3S653
db: uniprot

uniprot P32871 355
type: UnificationXref
id: P32871
db: uniprot

Histone acetyltransferase
type: ProteinReference
xref: uniprot F7E3A7 174
xref: PTHR10615:SF73
organism: Macaca mulatta

uniprot P24941 235
type: UnificationXref
id: P24941
db: uniprot

uniprot H2Q1Z0 343
type: UnificationXref
id: H2Q1Z0
db: uniprot

uniprot A0A2R8QIW0 33
type: UnificationXref
id: A0A2R8QIW0
db: uniprot

ncbitaxon 237631 32
type: UnificationXref
id: 237631
db: ncbitaxon

STATE_TRANSITION_LEFT__TRAF-RIGHT__TRAF-_re123
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re123 456
participant stoichiometry: PARTICIPANT STOICHIOMETRY re123 457
left: TRAF
interaction type: STATE_TRANSITION
right: TRAF

TRANSCRIPTION_LEFT__p48-RIGHT__p48-_re106
type: TemplateReaction
product: p48
xref: TRANSCRIPTION
participant: p48
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 42

uniprot D3ZC69 120
type: UnificationXref
id: D3ZC69
db: uniprot

uniprot A0A2I3RR15 233
type: UnificationXref
id: A0A2I3RR15
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__E2F_1-_ARF-RIGHT__Complex__ARF_E2F_1_-_re17
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 504
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 503
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 505
left: E2F-1
left: ARF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (ARF/E2F-1)

uniprot Q9Y243 299
type: UnificationXref
id: Q9Y243
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Inhibition of Angiogenesis and Metastasis
controller: KAI

uniprot A0A2I3TEU6 12
type: UnificationXref
id: A0A2I3TEU6
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR10177:SF59
organism: Monodelphis domestica

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__MTA2-RIGHT__MTA2-_re119
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

Tumor protein 63 (p63)
type: DnaReference
xref: PTHR11447:SF8
organism: Macaca mulatta

uniprot F7HID8 406
type: UnificationXref
id: F7HID8
db: uniprot

uniprot E2RK27 241
type: UnificationXref
id: E2RK27
db: uniprot

Mdm2
type: RnaRegion
comment: SPECIES_TYPE=RNA

Transcription factor E2f1
type: ProteinReference
xref: PTHR12081:SF18
xref: uniprot Q27368 262
organism: Drosophila melanogaster

uniprot E2QXA4 69
type: UnificationXref
id: E2QXA4
db: uniprot

PARTICIPANT STOICHIOMETRY re59 540
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

lys p53 s65 sa45 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys p53 s65 sa45 rs1 lys
modification type: acetylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=lys
comment: MODIFICATION_RESIDUE_ANGLE=0.0

PARTICIPANT STOICHIOMETRY re59 541
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

uniprot F7ATG0 384
type: UnificationXref
id: F7ATG0
db: uniprot

Cdc25C
type: Protein
entity reference: Cdc25C
comment: SPECIES_TYPE=PROTEIN

G2/mitotic-specific cyclin-B1
type: ProteinReference
xref: PTHR10177:SF193
xref: uniprot Q1LZG6 62
organism: Bos taurus

Tumor protein 63 (p63)
type: DnaReference
xref: PTHR11447:SF8
organism: Bos taurus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6X958 315
xref: PTHR45619:SF44
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re59 542
type: Stoichiometry
physical entity: Complex (Mdm2/p53)
stoichiometric coefficient: 1.0

HDAC1
type: Protein
entity reference: HDAC1
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Macaca mulatta

uniprot Q38BA2 374
type: UnificationXref
id: Q38BA2
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: DNA Repair
controller: p48

Mdm2 s30 sa173 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.217183888389608
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re114 477
type: Stoichiometry
physical entity: PML
stoichiometric coefficient: 1.0

Histone acetyltransferase
type: ProteinReference
xref: PTHR10615:SF73
xref: uniprot H2Q248 176
organism: Pan troglodytes

Apoptosis regulator BAX
type: DnaReference
xref: PTHR11256:SF42
organism: Bos taurus

Histone acetyltransferase KAT2B
type: ProteinReference
xref: uniprot Q9JHD1 304
xref: PTHR45750:SF2
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re114 478
type: Stoichiometry
physical entity: PML
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 508
type: Stoichiometry
physical entity: Complex (HDAC1/MTA)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 507
type: Stoichiometry
physical entity: HDAC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 506
type: Stoichiometry
physical entity: MTA2
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot A0A2I3TNH3 189
xref: PTHR12305:SF81
organism: Pan troglodytes

Cellular tumor antigen p53
type: DnaReference
xref: PTHR11447:SF6
organism: Canis lupus familiaris

NOXA
type: DnaRegion
entity reference: NOXA
comment: SPECIES_TYPE=GENE

PTHR46330:SF4
type: RelationshipXref
id: PTHR46330:SF4
db: PANTHER Family
relationship type: By Homology

PTHR46330:SF2
type: RelationshipXref
id: PTHR46330:SF2
db: PANTHER Family
relationship type: By Homology

PTHR46330:SF1
type: RelationshipXref
id: PTHR46330:SF1
db: PANTHER Family
relationship type: By Homology

PTHR46786:SF1
type: RelationshipXref
id: PTHR46786:SF1
db: PANTHER Family
relationship type: By Homology

CCNB1 isoform 1
type: ProteinReference
xref: PTHR10177:SF193
xref: uniprot H2QR05 54
organism: Pan troglodytes

Uncharacterized protein
type: DnaReference
xref: PTHR12011:SF39
organism: Macaca mulatta

uniprot H9FUJ1 225
type: UnificationXref
id: H9FUJ1
db: uniprot

uniprot A0A2I3TNH3 189
type: UnificationXref
id: A0A2I3TNH3
db: uniprot

Reactive oxygen species
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q0P594 330
xref: PTHR45619:SF44
organism: Bos taurus

PANTHER Pathway P00059 1
type: UnificationXref
id: P00059
db: PANTHER Pathway

uniprot P60483 199
type: UnificationXref
id: P60483
db: uniprot

uniprot E1B8D6 27
type: UnificationXref
id: E1B8D6
db: uniprot

Tumor protein p73
type: ProteinReference
xref: uniprot F7GA51 138
xref: PTHR11447:SF21
organism: Macaca mulatta

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47196 290
xref: PTHR24356:SF171
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10177:SF344
xref: uniprot W4XEA0 24
organism: Strongylocentrotus purpuratus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47197 291
xref: PTHR24356:SF176
organism: Rattus norvegicus

PCAF
type: Protein
entity reference: PCAF
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

TRANSLATION_LEFT__p21-RIGHT__P21-_re158
type: TemplateReaction
product: P21
xref: TRANSLATION
participant: P21
participant: p21
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot F7ECL6 91
type: UnificationXref
id: F7ECL6
db: uniprot

p53
type: DnaRegion
entity reference: Tumor protein p53
comment: SPECIES_TYPE=GENE

HDAC1 s3 sa158 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HDAC1
stoichiometric coefficient: 1.0

Protein Mdm4
type: ProteinReference
xref: uniprot O35618 227
organism: Mus musculus

uniprot F1MYE6 221
type: UnificationXref
id: F1MYE6
db: uniprot

PTHR44167:SF9
type: RelationshipXref
id: PTHR44167:SF9
db: PANTHER Family
relationship type: By Homology

ADGRB2 isoform 6
type: DnaReference
organism: Pan troglodytes

PML
type: Protein
entity reference: PML
comment: SPECIES_TYPE=PROTEIN

Complex (Cdc25C/Cyclin B/ Cdc2)
type: Complex
component stoichiometry: Cyclin B s26 sa164 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cdc2 s27 sa165 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cdc25C s25 sa163 STOICHIOMETRY ID COMPLEX
component: Cdc2
component: Cyclin B
component: Cdc25C
feature: ACTIVE 11
feature: COMPLEX BINDING FEATURE s113 csa5 426
feature: COMPLEX BINDING FEATURE s113 csa5 422
feature: COMPLEX BINDING FEATURE s113 csa5 424

uniprot F6RCU6 282
type: UnificationXref
id: F6RCU6
db: uniprot

PARTICIPANT STOICHIOMETRY re1 529
type: Stoichiometry
physical entity: a7_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 528
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

uniprot Q13315 80
type: UnificationXref
id: Q13315
db: uniprot

SERPINE1 isoform 1
type: DnaReference
xref: PTHR11461:SF49
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__p21-RIGHT__p21-_re75
control type: ACTIVATION
controller: p53

uniprot Q5F3U4 103
type: UnificationXref
id: Q5F3U4
db: uniprot

uniprot Q60823 293
type: UnificationXref
id: Q60823
db: uniprot

STATE_TRANSITION_LEFT__ATM_ATR-RIGHT__ATM_ATR-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 523
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 522
left: ATM/ATR
interaction type: STATE_TRANSITION
right: ATM/ATR

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 295

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
type: DnaReference
name: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
organism: Arabidopsis thaliana

ncbitaxon 10116 9
type: UnificationXref
id: 10116
db: ncbitaxon

Uncharacterized protein
type: DnaReference
organism: Gallus gallus

uniprot Q6GLE6 332
type: UnificationXref
id: Q6GLE6
db: uniprot

ARF
type: RnaRegion
comment: SPECIES_TYPE=RNA

NOXA
type: RnaRegion
comment: SPECIES_TYPE=RNA

UNKNOWN_TRANSITION_LEFT__p53-RIGHT__Reactive_oxygen_species-_re57
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re57 545
participant stoichiometry: PARTICIPANT STOICHIOMETRY re57 546
left: p53
interaction type: UNKNOWN_TRANSITION
right: Reactive oxygen species

Complex (Mdm2/p53)
type: Complex
component stoichiometry: Mdm2 s30 sa173 STOICHIOMETRY ID COMPLEX
component stoichiometry: p53 s31 sa174 STOICHIOMETRY ID COMPLEX
component: p53
component: Mdm2
feature: COMPLEX BINDING FEATURE s140 csa9 438
feature: COMPLEX BINDING FEATURE s140 csa9 440

uniprot P38936 339
type: UnificationXref
id: P38936
db: uniprot

ncbitaxon 559292 77
type: UnificationXref
id: 559292
db: ncbitaxon

PTHR45877:SF1
type: RelationshipXref
id: PTHR45877:SF1
db: PANTHER Family
relationship type: By Homology

Cyclin-dependent kinase 1
type: ProteinReference
xref: uniprot P48734 370
organism: Bos taurus

uniprot H2QLS0 29
type: UnificationXref
id: H2QLS0
db: uniprot

PML
type: DnaRegion
entity reference: Promyelocytic leukemia protein
comment: SPECIES_TYPE=GENE

PTHR10177:SF193
type: RelationshipXref
id: PTHR10177:SF193
db: PANTHER Family
relationship type: By Homology

Cyclin-dependent kinase 4 inhibitor B
type: DnaReference
organism: Mus musculus

uniprot F7FBX2 342
type: UnificationXref
id: F7FBX2
db: uniprot

PARTICIPANT STOICHIOMETRY re60 536
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re60 537
type: Stoichiometry
physical entity: Complex (Mdm2/p53)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re60 538
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re60 539
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 516
type: Stoichiometry
physical entity: Chk2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 517
type: Stoichiometry
physical entity: Chk2
stoichiometric coefficient: 1.0

Cyclin G1
type: DnaReference
xref: PTHR10177:SF59
organism: Canis lupus familiaris

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

uniprot F6U7A6 314
type: UnificationXref
id: F6U7A6
db: uniprot

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: ProteinReference
xref: uniprot P48316 253
xref: PTHR10411:SF3
organism: Mus musculus

uniprot F6TAI6 162
type: UnificationXref
id: F6TAI6
db: uniprot

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: ProteinReference
xref: PTHR10411:SF3
xref: uniprot P48317 254
organism: Rattus norvegicus

SIRT1 isoform 2
type: ProteinReference
xref: uniprot H2Q1Z0 343
xref: PTHR11085:SF15
organism: Pan troglodytes

ARF
type: Protein
entity reference: ARF
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa159 411
comment: SPECIES_TYPE=PROTEIN

GADD45G isoform 1
type: DnaReference
xref: PTHR10411:SF4
organism: Pan troglodytes

Apoptotic protease-activating factor 1
type: DnaReference
xref: PTHR22845:SF5
organism: Pan troglodytes

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 18

uniprot F1Q6Z7 313
type: UnificationXref
id: F1Q6Z7
db: uniprot

ser, thr p53 s5 sa3 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY ser, thr
feature location: ser, thr p53 s5 sa3 rs2 ser, thr
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.7773911668162987
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=ser, thr

Growth arrest and DNA-damage-inducible 45 beta
type: ProteinReference
xref: PTHR10411:SF5
xref: uniprot Q5U3Z2 257
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re124 455
type: Stoichiometry
physical entity: CBP
stoichiometric coefficient: 1.0

ncbitaxon 36329 372
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot Q13547 45
type: UnificationXref
id: Q13547
db: uniprot

STATE_TRANSITION_LEFT__Chk2-RIGHT__Chk2-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 518
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 519
left: Chk2
interaction type: STATE_TRANSITION
right: Chk2

STATE_TRANSITION_LEFT__Chk2-RIGHT__Chk2-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 517
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 516
left: Chk2
interaction type: STATE_TRANSITION
right: Chk2

Uncharacterized protein
type: DnaReference
xref: PTHR12011:SF39
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re124 454
type: Stoichiometry
physical entity: CBP
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__Ub-_Complex__Mdm2_p53_-RIGHT__Mdm2-_p53-_re60
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re60 539
participant stoichiometry: PARTICIPANT STOICHIOMETRY re60 536
participant stoichiometry: PARTICIPANT STOICHIOMETRY re60 537
participant stoichiometry: PARTICIPANT STOICHIOMETRY re60 538
left: Ub
left: Complex (Mdm2/p53)
interaction type: DISSOCIATION
right: Mdm2
right: p53

ncbitaxon 7955 22
type: UnificationXref
id: 7955
db: ncbitaxon

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__KAI-RIGHT__KAI-_re111
control type: ACTIVATION
controller: p53

ncbitaxon 9598 2
type: UnificationXref
id: 9598
db: ncbitaxon

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Reprimo-RIGHT__Reprimo-_re83
control type: ACTIVATION
controller: p53

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
organism: Danio rerio

ncbitaxon 9031 14
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot A0A3Q1M8V1 64
type: UnificationXref
id: A0A3Q1M8V1
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Zinc finger matrin-type 3
type: DnaReference
organism: Canis lupus familiaris

PTHR13808:SF1
type: RelationshipXref
id: PTHR13808:SF1
db: PANTHER Family
relationship type: By Homology

Insulin IGF pathway_BR_PKB cascade
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

B99
type: Protein
entity reference: B99
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: DnaReference
xref: PTHR11461:SF49
organism: Macaca mulatta

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__p53-RIGHT__p53-_re65
control type: ACTIVATION
controller: TRAF

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q9Z2A0 110
xref: PTHR24356:SF163
organism: Mus musculus

TRANSCRIPTION_LEFT__KILLER_DR5-RIGHT__KILLER_DRS-_re87
type: TemplateReaction
product: KILLER/DRS
xref: TRANSCRIPTION
participant: KILLER/DR5
participant: KILLER/DRS
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot P31947 268
type: UnificationXref
id: P31947
db: uniprot

uniprot P24860 58
type: UnificationXref
id: P24860
db: uniprot

uniprot E2QW70 234
type: UnificationXref
id: E2QW70
db: uniprot

PTHR10615:SF73
type: RelationshipXref
id: PTHR10615:SF73
db: PANTHER Family
relationship type: By Homology

uniprot Q9LT75 204
type: UnificationXref
id: Q9LT75
db: uniprot

PTEN
type: ProteinReference
xref: P01480
standard name: Phosphatase and tensin homolog deleted on chromosome 10
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.PTEN
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphatase and tensin homolog deleted on chromosome 10 Synonym: Synonym not specified Accession: P01480
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
member entity reference: IP16020p
member entity reference: Putative tyrosine-protein phosphatase TPTE
member entity reference: MCG118205, isoform CRA_c
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Bos taurus

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot O55173 98
xref: PTHR24356:SF163
organism: Rattus norvegicus

SIN3 transcription regulator family member A
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot A0A0G2K3H5 159
organism: Rattus norvegicus

Small ubiquitin-related modifier
type: ProteinReference
xref: uniprot F6WCW3 382
organism: Monodelphis domestica

uniprot P42771 407
type: UnificationXref
id: P42771
db: uniprot

Mdm2
type: Protein
entity reference: Mdm2
feature: S T Mdm2 s138 sa60 rs2
feature: Mdm2 s138 sa60 rs1
feature: S T Mdm2 s138 sa60 rs3
comment: SPECIES_TYPE=PROTEIN

Metastasis-associated 1 family member 2
type: ProteinReference
xref: uniprot F6YU32 89
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_re2
controller: PDK1/2

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot F6Z5R3 37
organism: Monodelphis domestica

uniprot A0A0G2JVC1 218
type: UnificationXref
id: A0A0G2JVC1
db: uniprot

Histone acetyltransferase KAT2B
type: ProteinReference
xref: uniprot Q92831 303
xref: PTHR45750:SF2
organism: Homo sapiens

CREB-binding protein
type: ProteinReference
xref: uniprot Q6JHU9 181
xref: PTHR13808:SF34
organism: Rattus norvegicus

DISSOCIATION
type: InteractionVocabulary

Siah
type: DnaRegion
entity reference: Seven in absentia homolog 1
comment: SPECIES_TYPE=GENE

uniprot Q7ZWB1 237
type: UnificationXref
id: Q7ZWB1
db: uniprot

WRN
type: Protein
entity reference: WRN
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EC89 90
xref: PTHR10865:SF4
organism: Macaca mulatta

uniprot Q6DK72 401
type: UnificationXref
id: Q6DK72
db: uniprot

uniprot Q9Z2A0 110
type: UnificationXref
id: Q9Z2A0
db: uniprot

E2F-1
type: Protein
entity reference: E2F-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa160 413
comment: SPECIES_TYPE=PROTEIN

Sumo-1 ligase
type: Protein
entity reference: Sumo-1 ligase
comment: SPECIES_TYPE=PROTEIN

lys p53 s5 sa3 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys p53 s5 sa3 rs1 lys
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=lys
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 6

PML
type: Protein
entity reference: PML
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

uniprot H9ZA72 116
type: UnificationXref
id: H9ZA72
db: uniprot

TRANSCRIPTION_LEFT__PERP-RIGHT__PERP-_re98
type: TemplateReaction
product: PERP
xref: TRANSCRIPTION
participant: PERP
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PTHR24201:SF4
type: RelationshipXref
id: PTHR24201:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q92831 303
type: UnificationXref
id: Q92831
db: uniprot

TNF receptor-associated factor
type: ProteinReference
xref: uniprot B5DFH7 153
organism: Rattus norvegicus

uniprot E1BEI6 68
type: UnificationXref
id: E1BEI6
db: uniprot

Werner syndrome ATP-dependent helicase homolog
type: ProteinReference
xref: uniprot O09053 113
organism: Mus musculus

TRANSCRIPTION_LEFT__Reprimo-RIGHT__Reprimo-_re83
type: TemplateReaction
product: Reprimo
xref: TRANSCRIPTION
participant: Reprimo
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

TRANSCRIPTION_LEFT__p110alpha-RIGHT__p110alpha-_re71
type: TemplateReaction
product: p110alpha
xref: TRANSCRIPTION
participant: p110alpha
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PTHR10828:SF64
type: RelationshipXref
id: PTHR10828:SF64
db: PANTHER Family
relationship type: By Homology

S T Mdm2 s138 sa60 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s138 sa60 rs2 S T
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.618441538509672

eco ECO:0000303 15
type: UnificationXref
id: ECO:0000303
db: eco

Tumor necrosis factor receptor superfamily member 6
type: DnaReference
xref: PTHR46874:SF1
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 502
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 501
left: p53
interaction type: STATE_TRANSITION
right: p53

PERP
type: DnaRegion
entity reference: p53 apoptosis effector related to PMP-22
comment: SPECIES_TYPE=GENE

TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re67
type: TemplateReaction
product: Mdm2
xref: TRANSCRIPTION
participant: Mdm2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Cdk2
type: ProteinReference
xref: P04625
standard name: Cyclin-dependent kinase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.Cdk2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cyclin dependent kinase 2
member entity reference: Cyclin-dependent kinase 2
member entity reference: Uncharacterized protein

uniprot K7DR10 73
type: UnificationXref
id: K7DR10
db: uniprot

E2F transcription factor 3
type: ProteinReference
xref: uniprot F6VW96 261
xref: PTHR12081:SF44
organism: Xenopus tropicalis

Small ubiquitin-related modifier
type: ProteinReference
xref: uniprot F6WCZ7 383
organism: Monodelphis domestica

PI3 K s19 sa162 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3-K
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 515
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 514
left: p53
interaction type: STATE_TRANSITION
right: p53

STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 512
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 513
left: p53
interaction type: STATE_TRANSITION
right: p53

S T Mdm2 s138 sa60 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s138 sa60 rs3 S T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6758332776215386

SIN3 transcription regulator family member A
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot F1MTR3 161
organism: Bos taurus

uniprot F7DU67 71
type: UnificationXref
id: F7DU67
db: uniprot

uniprot F1PY87 171
type: UnificationXref
id: F1PY87
db: uniprot

uniprot Q12701 102
type: UnificationXref
id: Q12701
db: uniprot

PTHR10828:SF46
type: RelationshipXref
id: PTHR10828:SF46
db: PANTHER Family
relationship type: By Homology

Maspin
type: DnaRegionReference
member entity reference: SERPINB5 isoform 1
member entity reference: Serpin family B member 5
member entity reference: Serpin B5
member entity reference: Uncharacterized protein
xref: G01569
comment: ENTITY_REFERENCE_NOTES=Long Name: Maspin Synonym: Mp Accession: G01569
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.Maspin

TRANSCRIPTION_LEFT__p21-RIGHT__p21-_re75
type: TemplateReaction
product: p21
xref: TRANSCRIPTION
participant: p21
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PML
type: RnaRegion
comment: SPECIES_TYPE=RNA

Histone acetyltransferase
type: ProteinReference
xref: PTHR45750:SF2
xref: uniprot A0A2I3TV67 301
organism: Pan troglodytes

PERP, TP53 apoptosis effector
type: DnaReference
organism: Rattus norvegicus

SIRT-1
type: Protein
entity reference: SIRT-1
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION
type: RelationshipTypeVocabulary

uniprot O94776 92
type: UnificationXref
id: O94776
db: uniprot

uniprot Q9FYH1 186
type: UnificationXref
id: Q9FYH1
db: uniprot

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__p53-RIGHT__p53-_re65
control type: INHIBITION
controller: Complex (Sin3/HDAC1)

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__ARF-RIGHT__ARF-_re73
control type: INHIBITION
controller: p53

p53
type: Protein
entity reference: p53
feature: ser, thr p53 s31 sa174 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa174 441
feature: lys p53 s31 sa174 rs1
comment: SPECIES_TYPE=PROTEIN

Cyclin E s21 sa170 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cyclin E
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot J9NS71 155
type: UnificationXref
id: J9NS71
db: uniprot

uniprot H2R902 248
type: UnificationXref
id: H2R902
db: uniprot

uniprot P04551 363
type: UnificationXref
id: P04551
db: uniprot

Fas cell surface death receptor
type: DnaReference
organism: Pan troglodytes

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 15

uniprot Q9R190 94
type: UnificationXref
id: Q9R190
db: uniprot

PAI
type: DnaRegion
entity reference: Plasminogen activator inhibitor 1
comment: SPECIES_TYPE=GENE

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 51

uniprot Q60520 167
type: UnificationXref
id: Q60520
db: uniprot

BCL2-associated X protein
type: DnaRegionReference
member entity reference: BCL2-associated X, apoptosis regulator a
member entity reference: BCL2-associated X protein
member entity reference: Apoptosis regulator BAX
member entity reference: Uncharacterized protein
xref: G01581
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.BAX
comment: ENTITY_REFERENCE_NOTES=Long Name: BCL2-associated X protein Synonym: Synonym not specified Accession: G01581
display name: BAX

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FM29 112
organism: Macaca mulatta

uniprot Q0P594 330
type: UnificationXref
id: Q0P594
db: uniprot

Cytokine-responsive protein CR6
type: DnaReference
xref: PTHR10411:SF4
organism: Macaca mulatta

uniprot O09053 113
type: UnificationXref
id: O09053
db: uniprot

PTHR10177:SF71
type: RelationshipXref
id: PTHR10177:SF71
db: PANTHER Family
relationship type: By Homology

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Mus musculus

P04635
type: UnificationXref
id: P04635
db: PANTHER Pathway Component

Insulin-like growth factor-binding protein 3
type: DnaReference
organism: Mus musculus

Apoptosis regulator BAX
type: DnaReference
xref: PTHR11256:SF42
organism: Rattus norvegicus

DNA Repair
type: Pathway

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Danio rerio

PTHR45619:SF42
type: RelationshipXref
id: PTHR45619:SF42
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot A7T2Q5 305
organism: Nematostella vectensis

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
type: DnaReference
xref: PTHR12305:SF81
organism: Caenorhabditis elegans

uniprot D4ACL8 67
type: UnificationXref
id: D4ACL8
db: uniprot

P04632
type: UnificationXref
id: P04632
db: PANTHER Pathway Component

uniprot P48967 217
type: UnificationXref
id: P48967
db: uniprot

P04631
type: UnificationXref
id: P04631
db: PANTHER Pathway Component

P04634
type: UnificationXref
id: P04634
db: PANTHER Pathway Component

ATR serine/threonine kinase
type: ProteinReference
xref: PTHR11139:SF69
xref: uniprot E2QXA4 69
organism: Canis lupus familiaris

P04633
type: UnificationXref
id: P04633
db: PANTHER Pathway Component

PTHR10177:SF59
type: RelationshipXref
id: PTHR10177:SF59
db: PANTHER Family
relationship type: By Homology

PTHR45619:SF44
type: RelationshipXref
id: PTHR45619:SF44
db: PANTHER Family
relationship type: By Homology

uniprot P34545 178
type: UnificationXref
id: P34545
db: uniprot

P04630
type: UnificationXref
id: P04630
db: PANTHER Pathway Component

P04628
type: UnificationXref
id: P04628
db: PANTHER Pathway Component

P04629
type: UnificationXref
id: P04629
db: PANTHER Pathway Component

P04624
type: UnificationXref
id: P04624
db: PANTHER Pathway Component

p110alpha
type: DnaRegionReference
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
xref: G04694
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.p110_alpha_
comment: ENTITY_REFERENCE_NOTES=Long Name: p110alpha Synonym: P110-alpha,PIK3CA Accession: G04694

P04625
type: UnificationXref
id: P04625
db: PANTHER Pathway Component

P04626
type: UnificationXref
id: P04626
db: PANTHER Pathway Component

P04627
type: UnificationXref
id: P04627
db: PANTHER Pathway Component

E3 ubiquitin-protein ligase
type: DnaReference
xref: PTHR45877:SF1
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: P53AIP1

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

P04622
type: UnificationXref
id: P04622
db: PANTHER Pathway Component

P04623
type: UnificationXref
id: P04623
db: PANTHER Pathway Component

P04620
type: UnificationXref
id: P04620
db: PANTHER Pathway Component

p53
type: ProteinReference
xref: P01485
standard name: Tumor protein p53
comment: ENTITY_REFERENCE_NOTES=Long Name: p53 Synonym: Synonym not specified Accession: P01485 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.p53
member entity reference: Cellular tumor antigen p53
member entity reference: Tumor protein 63 (p63)
member entity reference: Tumor protein p73
member entity reference: Tumor protein 63

Protein PML isoform 1
type: ProteinReference
xref: uniprot H9ZA72 116
xref: PTHR25462:SF241
organism: Macaca mulatta

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot P67775 329
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot P67774 328
organism: Bos taurus

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: DnaReference
xref: PTHR10411:SF3
organism: Mus musculus

P04616
type: UnificationXref
id: P04616
db: PANTHER Pathway Component

P04615
type: UnificationXref
id: P04615
db: PANTHER Pathway Component

P04614
type: UnificationXref
id: P04614
db: PANTHER Pathway Component

P04613
type: UnificationXref
id: P04613
db: PANTHER Pathway Component

GD-AIF
type: DnaRegion
comment: SPECIES_TYPE=GENE

P04619
type: UnificationXref
id: P04619
db: PANTHER Pathway Component

P04618
type: UnificationXref
id: P04618
db: PANTHER Pathway Component

P04617
type: UnificationXref
id: P04617
db: PANTHER Pathway Component

uniprot P30277 59
type: UnificationXref
id: P30277
db: uniprot

P04610
type: UnificationXref
id: P04610
db: PANTHER Pathway Component

P04611
type: UnificationXref
id: P04611
db: PANTHER Pathway Component

P04612
type: UnificationXref
id: P04612
db: PANTHER Pathway Component

Maspin
type: DnaRegion
entity reference: Maspin
comment: SPECIES_TYPE=GENE

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1MYJ4 276
organism: Bos taurus

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot O54857 197
xref: PTHR12305:SF81
organism: Rattus norvegicus

Apoptosis-inducing factor 2
type: DnaReference
organism: Homo sapiens

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot E2RJX4 274
organism: Canis lupus familiaris

MCG118205, isoform CRA_c
type: DnaReference
organism: Mus musculus

PTHR45619:SF12
type: RelationshipXref
id: PTHR45619:SF12
db: PANTHER Family
relationship type: By Homology

Cyclin-dependent kinase 4 inhibitor D
type: ProteinReference
xref: uniprot F7HID8 406
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1Q4F8 278
organism: Canis lupus familiaris

UNKNOWN_TRANSITION_LEFT__Apoptosis-RIGHT__Tumor_suppression-_re8
type: Interaction
xref: UNKNOWN TRANSITION
participant: Tumor suppression
participant: Apoptosis

Cdc25C
type: Protein
entity reference: Cdc25C
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa163 423
comment: SPECIES_TYPE=PROTEIN

MODULATION
type: Control
xref: MODULATION
controlled: UNKNOWN_TRANSITION_LEFT__p53-RIGHT__p53-_re113
controller: HMG1

STATE_TRANSITION_LEFT__PCAF-RIGHT__PCAF-_re122
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re122 458
participant stoichiometry: PARTICIPANT STOICHIOMETRY re122 459
left: PCAF
interaction type: STATE_TRANSITION
right: PCAF

uniprot A0A0G2K3H5 159
type: UnificationXref
id: A0A0G2K3H5
db: uniprot

Growth arrest and DNA damage-inducible protein GADD45 beta
type: DnaReference
xref: PTHR10411:SF5
organism: Mus musculus

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 7

Sumo-1 ligase
type: ProteinReference
xref: P04635
standard name: Small ubiquitin-like modifier 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Small ubiquitin-like modifier 1 Synonym: PIC1,SMT3 homolog 3,SUMO1,Sentrin,UBL1,Ubiquitin-like 1 Accession: P04635
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.Sumo_minus_1_br_ligase
member entity reference: Small ubiquitin-like modifier 2
member entity reference: Small ubiquitin-related modifier
member entity reference: Small ubiquitin-related modifier 3
member entity reference: Uncharacterized protein
member entity reference: Small ubiquitin-related modifier 1
member entity reference: Small ubiquitin-related modifier 2
member entity reference: Small ubiquitin-related modifier 3-like

MODULATION
type: Control
xref: MODULATION
controlled: Apoptosis
controller: Reactive oxygen species

Serine-protein kinase ATM
type: ProteinReference
xref: uniprot Q62388 82
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re123 456
type: Stoichiometry
physical entity: TRAF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re123 457
type: Stoichiometry
physical entity: TRAF
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot Q7PD38 334
organism: Anopheles gambiae

uniprot F7G3I5 353
type: UnificationXref
id: F7G3I5
db: uniprot

PARTICIPANT STOICHIOMETRY re19 499
type: Stoichiometry
physical entity: PiP2
stoichiometric coefficient: 1.0

Cyclin-G1
type: DnaReference
organism: Homo sapiens

ncbitaxon 227321 66
type: UnificationXref
id: 227321
db: ncbitaxon

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot B3S653 307
xref: PTHR45619:SF12
organism: Trichoplax adhaerens

CDKN2D isoform 1
type: DnaReference
organism: Pan troglodytes

uniprot A0A3Q2U4X3 273
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

Lysine acetyltransferase 2B
type: ProteinReference
xref: uniprot F1PN31 302
organism: Canis lupus familiaris

HMG1
type: ProteinReference
xref: P04619
standard name: High mobility group protein 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: High mobility group protein 1 Synonym: Amphoterin,HMGB1,High mobility group box 1,Nonhistone chromosomal protein HMG1 Accession: P04619
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.HMG1
member entity reference: Uncharacterized protein
member entity reference: High mobility group protein B1
member entity reference: High mobility group protein B1-like
member entity reference: High-mobility group (nonhistone chromosomal) protein 1-like 1

PARTICIPANT STOICHIOMETRY re128 451
type: Stoichiometry
physical entity: Insulin IGF pathway_BR_PKB cascade
stoichiometric coefficient: 1.0

UVSB
type: ProteinReference
xref: uniprot C8VB89 65
organism: Emericella nidulans

uniprot P09429 124
type: UnificationXref
id: P09429
db: uniprot

PUMA
type: DnaRegion
comment: SPECIES_TYPE=GENE

Uncharacterized protein
type: DnaReference
xref: PTHR12305:SF81
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re128 450
type: Stoichiometry
physical entity: Survival Signals
stoichiometric coefficient: 1.0

Cyclin-dependent kinase inhibitor 1A
type: DnaRegionReference
member entity reference: Cyclin-dependent kinase inhibitor 1A
member entity reference: Cyclin-dependent kinase inhibitor 1
xref: G01580
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclin-dependent kinase inhibitor 1A Synonym: p21CIP1,p21WAF1 Accession: G01580
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.p21
display name: p21

Zinc finger matrin-type protein 3
type: DnaReference
xref: PTHR46786:SF1
organism: Mus musculus

BAI-1
type: DnaRegionReference
member entity reference: ADGRB2 isoform 6
member entity reference: Uncharacterized protein
member entity reference: Adhesion G protein-coupled receptor B3
member entity reference: ADGRB3 isoform 1
member entity reference: Adhesion G protein-coupled receptor B2
member entity reference: Adhesion G protein-coupled receptor B1
xref: G04699
comment: ENTITY_REFERENCE_NOTES=Long Name: BAI-1 Synonym: Synonym not specified Accession: G04699
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.BAI_minus_1

uniprot Q9WUA6 298
type: UnificationXref
id: Q9WUA6
db: uniprot

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSLATION_LEFT__Mdm2-RIGHT__Mdm2-_re68
control type: INHIBITION
controller: ARF

Tumor protein 63
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot Q9H3D4 150
organism: Homo sapiens

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

TRANSCRIPTION_LEFT__Wip1-RIGHT__Wip_1-_re104
type: TemplateReaction
product: Wip 1
xref: TRANSCRIPTION
participant: Wip 1
participant: Wip1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

Cdc25C
type: ProteinReference
xref: P04624
standard name: Cell division cycle 25C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cell division cycle 25C Synonym: Mitosis incucer CDC25 Accession: P04624
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.Cdc25C
member entity reference: M-phase inducer phosphatase 1
member entity reference: Cell division cycle 25C
member entity reference: M-phase inducer phosphatase 3
member entity reference: Uncharacterized protein

uniprot F6RRA8 172
type: UnificationXref
id: F6RRA8
db: uniprot

Growth arrest and DNA damage-inducible protein GADD45 beta
type: ProteinReference
xref: PTHR10411:SF5
xref: uniprot Q5E9A5 256
organism: Bos taurus

CHEK2 isoform 9
type: ProteinReference
xref: uniprot A0A2I3RSK6 205
xref: PTHR44167:SF9
organism: Pan troglodytes

a167_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

PML isoform 6
type: ProteinReference
xref: uniprot H2Q9S3 115
xref: PTHR25462:SF241
organism: Pan troglodytes

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__p53-RIGHT__p53-_re65
control type: INHIBITION
controller: Complex (HDAC1/MTA)

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SSE6 243
xref: PTHR10411:SF3
organism: Monodelphis domestica

PAI
type: RnaRegion
comment: SPECIES_TYPE=RNA

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q7QK56 294
organism: Anopheles gambiae

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: Siah

uniprot B2RWS6 26
type: UnificationXref
id: B2RWS6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot A0A2I3T9Y4 271
organism: Pan troglodytes

uniprot F7GQ86 223
type: UnificationXref
id: F7GQ86
db: uniprot

Thrombospondin 1
type: DnaReference
xref: PTHR10199:SF78
organism: Pan troglodytes

uniprot Q92793 183
type: UnificationXref
id: Q92793
db: uniprot

Cyclin-dependent kinase inhibitor 1A
type: ProteinReference
xref: uniprot Q64315 341
xref: PTHR46778:SF1
organism: Rattus norvegicus

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot O08586 196
xref: PTHR12305:SF81
organism: Mus musculus

uniprot A0A2I3T8F5 47
type: UnificationXref
id: A0A2I3T8F5
db: uniprot

ncbitaxon 284812 75
type: UnificationXref
id: 284812
db: ncbitaxon

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: PIGs

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F1MKA9 134
organism: Bos taurus

Tumor protein 63
type: DnaReference
xref: PTHR11447:SF8
organism: Rattus norvegicus

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: uniprot P23804 229
xref: PTHR13844:SF15
organism: Mus musculus

Cdc2
type: ProteinReference
xref: P04634
standard name: Cell division cycle 2
comment: ENTITY_REFERENCE_NOTES=Long Name: Cell division cycle 2 Synonym: Cdk1,Cell cycle controller,Cyclin-dependent kinase 1,P34 Accession: P04634
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.Cdc2
member entity reference: Cyclin dependent kinase 2
member entity reference: Cyclin-dependent kinase 1
member entity reference: Cell division control protein 2 homolog 2
member entity reference: CDK1 isoform 1
member entity reference: Cyclin-dependent kinase 2
member entity reference: Cell division control protein 2 homolog
member entity reference: Cyclin-dependent kinase A-2
member entity reference: Cell division related protein kinase 2, putative
member entity reference: Uncharacterized protein
member entity reference: Cyclin dependent kinase 1
member entity reference: Cell division control protein 2

uniprot Q12933 157
type: UnificationXref
id: Q12933
db: uniprot

Growth arrest and DNA damage inducible gamma
type: DnaReference
xref: PTHR10411:SF4
organism: Bos taurus

uniprot E2RGJ9 358
type: UnificationXref
id: E2RGJ9
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P56424 146
organism: Macaca mulatta

Serine/threonine-protein kinase TEL1
type: ProteinReference
xref: uniprot P38110 76
organism: Saccharomyces cerevisiae

Survival Signals
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

Serine/threonine-protein kinase MEC1
type: ProteinReference
xref: uniprot P38111 78
organism: Saccharomyces cerevisiae

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Sumo_1_ligase-RIGHT__Sumo_1_ligase-_re116
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

uniprot Q7T3L7 378
type: UnificationXref
id: Q7T3L7
db: uniprot

ARF
type: ProteinReference
xref: P01482
standard name: Cyclin-dependent kinase inhibitor 2A
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.ARF
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Alternative reading frame (tumor-suppresor protein) Synonym: Cyclin-dependent kinase inhibitor 2A,p14ARF(humans),p19ARF (mouse) Accession: P01482 Pathway Link: P04393|P04576|Ras Pathway*P04398|P04655|p53 pathway feedback loops 2
member entity reference: Cyclin-dependent kinase inhibitor 2A
member entity reference: Cyclin-dependent kinase 4 inhibitor D
member entity reference: CDKN2D isoform 1

E3 ubiquitin-protein ligase
type: DnaReference
xref: PTHR45877:SF1
organism: Macaca mulatta

WRN
type: ProteinReference
xref: P04617
standard name: WRN gene
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.WRN
comment: ENTITY_REFERENCE_NOTES=Long Name: WRN gene Synonym: DNA helicase, RECQ-like, type 3,RECQ3,RECQL2 Accession: P04617
member entity reference: Werner syndrome RecQ like helicase
member entity reference: Werner syndrome ATP-dependent helicase homolog
member entity reference: Werner syndrome ATP-dependent helicase
member entity reference: Uncharacterized protein

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PERP-RIGHT__PERP-_re98
control type: ACTIVATION
controller: p53

Small ubiquitin-related modifier 1
type: ProteinReference
xref: uniprot Q5E9D1 393
organism: Bos taurus

uniprot H2RG60 385
type: UnificationXref
id: H2RG60
db: uniprot

P110alpha
type: Protein
entity reference: P110alpha
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

14-3-3 protein sigma
type: ProteinReference
xref: uniprot Q0VC36 269
organism: Bos taurus

CD82 antigen
type: DnaReference
organism: Rattus norvegicus

TRANSCRIPTION_LEFT__GD_AIF-RIGHT__GD_AIF-_re110
type: TemplateReaction
product: GD-AIF
xref: TRANSCRIPTION
participant: GD-AIF
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Metastasis-associated 1 family, member 2
type: ProteinReference
xref: uniprot B2GV01 87
xref: PTHR10865:SF4
organism: Rattus norvegicus

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 2

p53 pathway
type: Pathway
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re3
pathway component: UNKNOWN_TRANSITION_LEFT__Senescence-RIGHT__Aging-_re64
pathway component: TRANSCRIPTION_LEFT__Apaf-RIGHT__Apaf-_re90
pathway component: TRANSCRIPTION_LEFT__Wip1-RIGHT__Wip_1-_re104
pathway component: STATE_TRANSITION_LEFT__ATM_ATR-RIGHT__ATM_ATR-_re4
pathway component: TRANSLATION_LEFT__B99-RIGHT__B99-_re80
pathway component: TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re69
pathway component: STATE_TRANSITION_LEFT__MTA2-RIGHT__MTA2-_re119
pathway component: TRANSCRIPTION_LEFT__KILLER_DR5-RIGHT__KILLER_DRS-_re87
pathway component: MODULATION
pathway component: TRANSCRIPTION_LEFT__BAL1-RIGHT__BAL1-_re109
pathway component: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re18
pathway component: TRANSLATION_LEFT__PML-RIGHT__PML-_re89
pathway component: STATE_TRANSITION_LEFT__PCAF-RIGHT__PCAF-_re122
pathway component: STATE_TRANSITION_LEFT__PML-RIGHT__PML-_re114
pathway component: TRANSCRIPTION_LEFT__p53-RIGHT__p53-_re65
pathway component: TRANSCRIPTION_LEFT__Scotin-RIGHT__Scotin-_re99
pathway component: TRANSLATION_LEFT__14_3_3-RIGHT__14_3_3-_re78
pathway component: STATE_TRANSITION_LEFT__Mdm2-RIGHT__a167_degraded-_re62
pathway component: STATE_TRANSITION_LEFT__Chk2-RIGHT__Chk2-_re11
pathway component: STATE_TRANSITION_LEFT__TRAF-RIGHT__TRAF-_re123
pathway component: TRANSCRIPTION_LEFT__KAI-RIGHT__KAI-_re111
pathway component: DISSOCIATION_LEFT__Ub-_Complex__Mdm2_p53_-RIGHT__Mdm2-_p53-_re60
pathway component: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re63
pathway component: TRANSCRIPTION_LEFT__B99-RIGHT__B99-_re79
pathway component: TRANSCRIPTION_LEFT__PIDD-RIGHT__PIDD-_re86
pathway component: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_re2
pathway component: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re14
pathway component: TRANSLATION_LEFT__GADD45-RIGHT__GADD45-_re82
pathway component: TRANSCRIPTION_LEFT__14_3_3-RIGHT__14_3_3-_re77
pathway component: STATE_TRANSITION_LEFT__PiP3-RIGHT__PiP2-_re20
pathway component: STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_re22
pathway component: TRANSLATION_LEFT__PTEN-RIGHT__PTEN-_re70
pathway component: STATE_TRANSITION_LEFT__Sumo_1_ligase-RIGHT__Sumo_1_ligase-_re116
pathway component: TRANSCRIPTION_LEFT__Siah-RIGHT__Siah-_re97
pathway component: TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re67
pathway component: STATE_TRANSITION_LEFT__SIRT_1-RIGHT__SIRT_1-_re125
pathway component: TRANSCRIPTION_LEFT__IGF_BP3-RIGHT__IGF_BP3-_re96
pathway component: TRANSCRIPTION_LEFT__Maspin-RIGHT__Maspin-_re107
pathway component: STATE_TRANSITION_LEFT__p53-RIGHT__a7_degraded-_re1
pathway component: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re61
pathway component: TRANSCRIPTION_LEFT__PML-RIGHT__PML-_re88
pathway component: STATE_TRANSITION_LEFT__Sin3-RIGHT__Sin3-_re121
pathway component: TRANSCRIPTION_LEFT__PAG608-RIGHT__PAG608-_re100
pathway component: HETERODIMER_ASSOCIATION_LEFT__Cdc2-_Cdc25C-_Cyclin_B-RIGHT__Complex__Cdc25C_Cyclin_B__Cdc2_-_re29
pathway component: TRANSCRIPTION_LEFT__GD_AIF-RIGHT__GD_AIF-_re110
pathway component: TRANSLATION_LEFT__ARF-RIGHT__ARF-_re74
pathway component: TRANSCRIPTION_LEFT__PERP-RIGHT__PERP-_re98
pathway component: TRANSCRIPTION_LEFT__ARF-RIGHT__ARF-_re73
pathway component: TRANSCRIPTION_LEFT__NOXA-RIGHT__NOXA-_re94
pathway component: HETERODIMER_ASSOCIATION_LEFT__MTA2-_HDAC1-RIGHT__Complex__HDAC1_MTA_-_re16
pathway component: TRANSCRIPTION_LEFT__R2-RIGHT__R2-_re105
pathway component: UNKNOWN_TRANSITION_LEFT__Apoptosis-RIGHT__Tumor_suppression-_re8
pathway component: TRANSCRIPTION_LEFT__FAS-RIGHT__FAS-_re85
pathway component: STATE_TRANSITION_LEFT__P300-RIGHT__P300-_re118
pathway component: TRANSLATION_LEFT__p21-RIGHT__P21-_re158
pathway component: UNKNOWN_TRANSITION_LEFT__p53-RIGHT__Reactive_oxygen_species-_re57
pathway component: STATE_TRANSITION_LEFT__Mdm2-RIGHT__a101_degraded-_re26
pathway component: HETERODIMER_ASSOCIATION_LEFT__E2F_1-_ARF-RIGHT__Complex__ARF_E2F_1_-_re17
pathway component: STATE_TRANSITION_LEFT__CBP-RIGHT__CBP-_re124
pathway component: TRANSCRIPTION_LEFT__Reprimo-RIGHT__Reprimo-_re83
pathway component: TRANSCRIPTION_LEFT__BAI_1-RIGHT__BAI1-_re101

STATE_TRANSITION_LEFT__Mdm2-RIGHT__a167_degraded-_re62
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re62 532
participant stoichiometry: PARTICIPANT STOICHIOMETRY re62 533
left: Mdm2
interaction type: STATE_TRANSITION
right: a167_degraded

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re5
controller: Chk2

uniprot H2RC87 266
type: UnificationXref
id: H2RC87
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MDX9 191
xref: PTHR12305:SF81
organism: Bos taurus

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: DnaReference
xref: PTHR10411:SF3
organism: Homo sapiens

Growth arrest and DNA damage-inducible protein GADD45 beta
type: DnaReference
xref: PTHR10411:SF5
organism: Homo sapiens

uniprot P63331 327
type: UnificationXref
id: P63331
db: uniprot

Growth arrest and DNA damage-inducible protein GADD45 gamma
type: DnaReference
xref: PTHR10411:SF4
organism: Homo sapiens

a101_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

Insulin-like growth factor-binding protein 3
type: DnaReference
organism: Rattus norvegicus

uniprot P11440 365
type: UnificationXref
id: P11440
db: uniprot

STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 491
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 490
left: Mdm2
interaction type: STATE_TRANSITION
right: Mdm2

uniprot Q27368 262
type: UnificationXref
id: Q27368
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot Q29537 149
organism: Canis lupus familiaris

Mdm2 s142 sa101 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.217183888389608
comment: MODIFICATION_RESIDUE_NAME=

Mdm2 s138 sa60 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.217183888389608
comment: MODIFICATION_RESIDUE_NAME=

PTHR10865:SF4
type: RelationshipXref
id: PTHR10865:SF4
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 531
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 530
left: Mdm2
interaction type: STATE_TRANSITION
right: Mdm2

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__CBP-RIGHT__CBP-_re124
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

uniprot P67939 147
type: UnificationXref
id: P67939
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__GADD45-_B99-RIGHT__Complex__GADD45_B99_-_re30
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 464
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 466
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 465
left: B99
left: GADD45
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GADD45/B99)

STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 534
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 535
left: Mdm2
interaction type: STATE_TRANSITION
right: Mdm2

uniprot Q8QGH2 403
type: UnificationXref
id: Q8QGH2
db: uniprot

MTA2
type: Protein
entity reference: MTA2
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re113 479
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot H2QC53 139
xref: PTHR11447:SF6
organism: Pan troglodytes

p21
type: RnaRegion
comment: SPECIES_TYPE=RNA

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re58
controller: ATM/ATR

S T Mdm2 s141 sa100 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s141 sa100 rs3 S T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6758332776215386

Ribonucleotide reductase M2 polypeptide
type: DnaReference
organism: Rattus norvegicus

G2/mitotic-specific cyclin-B1
type: ProteinReference
xref: PTHR10177:SF193
xref: uniprot P24860 58
organism: Mus musculus

uniprot Q13535 81
type: UnificationXref
id: Q13535
db: uniprot

PARTICIPANT STOICHIOMETRY re4 523
type: Stoichiometry
physical entity: ATM/ATR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 522
type: Stoichiometry
physical entity: ATM/ATR
stoichiometric coefficient: 1.0

G1/S-specific cyclin-E1
type: ProteinReference
xref: uniprot P24864 17
xref: PTHR10177:SF71
organism: Homo sapiens

STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re58
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re58 543
participant stoichiometry: PARTICIPANT STOICHIOMETRY re58 544
left: Mdm2
interaction type: STATE_TRANSITION
right: Mdm2

Uncharacterized protein
type: DnaReference
organism: Macaca mulatta

p48
type: RnaRegion
comment: SPECIES_TYPE=RNA

Chk2
type: Protein
entity reference: Chk2
feature: ACTIVE 11
feature: Chk2 s41 sa23 rs1
comment: SPECIES_TYPE=PROTEIN

CD82 antigen
type: DnaReference
organism: Homo sapiens

G2 and S phase-expressed protein 1
type: DnaReference
xref: PTHR21584:SF10
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

uniprot Q9LE42 187
type: UnificationXref
id: Q9LE42
db: uniprot

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot H9FUJ1 225
organism: Macaca mulatta

uniprot F7BU66 264
type: UnificationXref
id: F7BU66
db: uniprot

uniprot F7H3V1 165
type: UnificationXref
id: F7H3V1
db: uniprot

uniprot E2R2S2 240
type: UnificationXref
id: E2R2S2
db: uniprot

S T Mdm2 s141 sa100 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s141 sa100 rs2 S T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.618441538509672

PTHR24356:SF163
type: RelationshipXref
id: PTHR24356:SF163
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re113 480
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__FAS-RIGHT__FAS-_re85
type: TemplateReaction
product: FAS
xref: TRANSCRIPTION
participant: FAS
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot A0A167VDT2 130
type: UnificationXref
id: A0A167VDT2
db: uniprot

Cyclin E
type: Protein
entity reference: Cyclin E
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa170 421
comment: SPECIES_TYPE=PROTEIN

uniprot Q8INB9 296
type: UnificationXref
id: Q8INB9
db: uniprot

Scotin
type: DnaRegion
comment: SPECIES_TYPE=GENE

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot P60484 200
xref: PTHR12305:SF81
organism: Homo sapiens

uniprot Q3ZBN6 255
type: UnificationXref
id: Q3ZBN6
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot P60483 199
xref: PTHR12305:SF81
organism: Canis lupus familiaris

TRANSCRIPTION_LEFT__PAI-RIGHT__PAI-_re102
type: TemplateReaction
product: PAI
xref: TRANSCRIPTION
participant: PAI
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot F6QE96 279
type: UnificationXref
id: F6QE96
db: uniprot

ncbitaxon 3702 108
type: UnificationXref
id: 3702
db: ncbitaxon

Cdc2
type: Protein
entity reference: Cdc2
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PAG608-RIGHT__PAG608-_re100
control type: ACTIVATION
controller: p53

Uncharacterized protein
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot F7BEI4 16
organism: Macaca mulatta

PDK1/2
type: ProteinReference
xref: P04616
standard name: 3-phosphoinositide-dependent protein kinase 1 and 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: 3-phosphoinositide-dependent protein kinase 1 and 2 Synonym: Synonym not specified Accession: P04616
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.PDK1_slash_2
member entity reference: 3-phosphoinositide-dependent protein kinase 1
member entity reference: Os01g0872800 protein
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase ppk21
member entity reference: Serine/threonine-protein kinase PKH1
member entity reference: 3-phosphoinositide dependent protein kinase 1
member entity reference: Serine/threonine-protein kinase PKH2
member entity reference: Serine/threonine-protein kinase PKH3
member entity reference: Serine/threonine-protein kinase ksg1

uniprot O54857 197
type: UnificationXref
id: O54857
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Siah-RIGHT__Siah-_re97
control type: ACTIVATION
controller: p53

ATM/ATR
type: Protein
entity reference: ATM/ATR
feature: ATM ATR s15 sa13 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q248 176
type: UnificationXref
id: H2Q248
db: uniprot

Growth arrest and DNA damage inducible beta
type: ProteinReference
xref: PTHR10411:SF5
xref: uniprot E2R2S2 240
organism: Canis lupus familiaris

uniprot F7E5M4 317
type: UnificationXref
id: F7E5M4
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re67
control type: ACTIVATION
controller: p53

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__GADD45-RIGHT__GADD45-_re81
control type: ACTIVATION
controller: p53

uniprot F7E905 175
type: UnificationXref
id: F7E905
db: uniprot

p21
type: DnaRegion
entity reference: Cyclin-dependent kinase inhibitor 1A
comment: SPECIES_TYPE=GENE

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot B7QGY5 309
organism: Ixodes scapularis

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P04637 144
organism: Homo sapiens

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot F1Q6Z7 313
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FBX2 342
xref: PTHR11085:SF15
organism: Macaca mulatta

Mdm2
type: Protein
entity reference: Mdm2
feature: Mdm2 s138 sa2 rs1
feature: ACTIVE 11
feature: S T Mdm2 s138 sa2 rs2
feature: S T Mdm2 s138 sa2 rs3
comment: SPECIES_TYPE=PROTEIN

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 10

Mdm2
type: DnaRegion
comment: SPECIES_TYPE=GENE

IP16020p
type: ProteinReference
xref: uniprot Q7KMQ6 201
xref: PTHR12305:SF81
organism: Drosophila melanogaster

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Pan troglodytes

uniprot F1MTR3 161
type: UnificationXref
id: F1MTR3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E905 175
xref: PTHR13808:SF34
organism: Monodelphis domestica

Ribonucleoside-diphosphate reductase subunit M2
type: DnaReference
organism: Mus musculus

Serine/threonine-protein kinase ppk21
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9Y7J6 109
organism: Schizosaccharomyces pombe

Cyclin-dependent kinase 4 inhibitor D
type: ProteinReference
xref: uniprot Q60773 409
organism: Mus musculus

PERP, TP53 apoptosis effector
type: DnaReference
organism: Canis lupus familiaris

Serpin B5
type: DnaReference
xref: PTHR11461:SF55
organism: Mus musculus

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot F1Q2Y3 96
organism: Canis lupus familiaris

uniprot P47197 291
type: UnificationXref
id: P47197
db: uniprot

High mobility group protein B1-like
type: ProteinReference
xref: uniprot D3ZIU9 122
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re61 534
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re61 535
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__TSP1-RIGHT__TSP1-_re108
type: TemplateReaction
product: TSP1
xref: TRANSCRIPTION
participant: TSP1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Serine/threonine-protein kinase ksg1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q12701 102
organism: Schizosaccharomyces pombe

TRANSCRIPTION_LEFT__BAL1-RIGHT__BAL1-_re109
type: TemplateReaction
product: BAL1
xref: TRANSCRIPTION
participant: BAL1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Gallus gallus

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Mus musculus

uniprot A0A2I3RE00 219
type: UnificationXref
id: A0A2I3RE00
db: uniprot

uniprot P31750 288
type: UnificationXref
id: P31750
db: uniprot

CCNG1 isoform 2
type: DnaReference
organism: Pan troglodytes

TRAF
type: Protein
entity reference: TRAF
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0G2K6P4 119
type: UnificationXref
id: A0A0G2K6P4
db: uniprot

uniprot P63166 391
type: UnificationXref
id: P63166
db: uniprot

PTHR13844:SF15
type: RelationshipXref
id: PTHR13844:SF15
db: PANTHER Family
relationship type: By Homology

Adhesion G protein-coupled receptor B3
type: DnaReference
organism: Monodelphis domestica

Adhesion G protein-coupled receptor B3
type: DnaReference
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Sin3-RIGHT__Sin3-_re121
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re121 461
participant stoichiometry: PARTICIPANT STOICHIOMETRY re121 460
left: Sin3
interaction type: STATE_TRANSITION
right: Sin3

uniprot F7DUD6 352
type: UnificationXref
id: F7DUD6
db: uniprot

Cellular tumor antigen p53
type: DnaReference
xref: PTHR11447:SF6
organism: Homo sapiens

PCAF
type: Protein
entity reference: PCAF
comment: SPECIES_TYPE=PROTEIN

uniprot P61959 389
type: UnificationXref
id: P61959
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__NOXA-RIGHT__NOXA-_re94
control type: ACTIVATION
controller: p53

Serine/threonine-protein kinase ATR
type: ProteinReference
xref: PTHR11139:SF69
xref: uniprot Q13535 81
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Bos taurus

MODULATION
type: Control
xref: MODULATION
controlled: UNKNOWN_TRANSITION_LEFT__p53-RIGHT__p53-_re113
controller: PML

PIGs
type: RnaRegion
comment: SPECIES_TYPE=RNA

STATE_TRANSITION
type: RelationshipTypeVocabulary

Cdc25C s25 sa163 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cdc25C
stoichiometric coefficient: 1.0

Cdk2 s23 sa167 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cdk2
stoichiometric coefficient: 1.0

uniprot M0R7R5 123
type: UnificationXref
id: M0R7R5
db: uniprot

uniprot Q8T9S7 202
type: UnificationXref
id: Q8T9S7
db: uniprot

uniprot P61956 387
type: UnificationXref
id: P61956
db: uniprot

Histone deacetylase 1
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot Q13547 45
organism: Homo sapiens

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__BAL1-RIGHT__BAL1-_re109
control type: ACTIVATION
controller: p53

Tumor protein p73
type: ProteinReference
xref: uniprot D4AA88 132
xref: PTHR11447:SF21
organism: Rattus norvegicus

SFN isoform 1
type: ProteinReference
xref: uniprot H2RC87 266
xref: PTHR18860:SF14
organism: Pan troglodytes

uniprot K7CDC2 286
type: UnificationXref
id: K7CDC2
db: uniprot

Similar to 14-3-3 protein sigma
type: ProteinReference
xref: uniprot Q5EBB0 270
xref: PTHR18860:SF14
organism: Rattus norvegicus

B99
type: DnaRegionReference
member entity reference: Uncharacterized protein
member entity reference: G-2 and S-phase expressed 1
member entity reference: G2 and S phase-expressed protein 1
xref: G04697
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.B99
comment: ENTITY_REFERENCE_NOTES=Long Name: B99 Synonym: Gtse1 Accession: G04697

KNOWN_TRANSITION_OMITTED_LEFT__Survival_Signals-RIGHT__Insulin_IGF_pathway_BR_PKB_cascade-_re128
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re128 450
participant stoichiometry: PARTICIPANT STOICHIOMETRY re128 451
left: Survival Signals
interaction type: KNOWN_TRANSITION_OMITTED
right: Insulin IGF pathway_BR_PKB cascade

Histone acetyltransferase HAC5
type: ProteinReference
xref: uniprot Q9LE42 187
xref: PTHR13808:SF30
organism: Arabidopsis thaliana

Growth arrest and DNA damage-inducible gamma
type: ProteinReference
xref: PTHR10411:SF4
xref: uniprot Q6DIJ3 258
organism: Xenopus tropicalis

TSP1
type: RnaRegion
comment: SPECIES_TYPE=RNA

HETERODIMER_ASSOCIATION_LEFT__P21-_Complex__Cdk2_Cyclin_E_-RIGHT__Complex__P21_Cdk2__Cyclin_E_-_re27
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 486
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 485
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 487
left: P21
left: Complex (Cdk2/Cyclin E)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (P21/Cdk2/ Cyclin E)

MTA2
type: Protein
entity reference: MTA2
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q5F3U4 103
organism: Gallus gallus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q8UUX0 297
organism: Danio rerio

Ribonucleoside-diphosphate reductase subunit M2
type: DnaReference
organism: Rattus norvegicus

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 179

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__WRN-RIGHT__WRN-_re117
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

PP2A
type: ProteinReference
xref: P04630
standard name: Protein phosphatase 2A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.PP2A
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein phosphatase 2A Synonym: Synonym not specified Accession: P04630
member entity reference: Serine/threonine-protein phosphatase
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
member entity reference: Serine/threonine-protein phosphatase PP2A

Tumor necrosis factor receptor superfamily member 10B
type: DnaReference
xref: PTHR46330:SF4
organism: Mus musculus

uniprot Q9C5X9 184
type: UnificationXref
id: Q9C5X9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re24
controller: Mdm2

Mdm2
type: Protein
entity reference: Mdm2
feature: Mdm2 s30 sa173 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa173 439
feature: ACTIVE 11
feature: S T Mdm2 s30 sa173 rs2
feature: S T Mdm2 s30 sa173 rs3
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Scotin-RIGHT__Scotin-_re99
control type: ACTIVATION
controller: p53

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot Q9JJP2 151
organism: Mus musculus

Tumor protein 63
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot Q9JJP6 152
organism: Rattus norvegicus

Siah
type: RnaRegion
comment: SPECIES_TYPE=RNA

Adhesion G protein-coupled receptor B2
type: DnaReference
organism: Canis lupus familiaris

Apoptotic protease-activating factor 1
type: DnaReference
xref: PTHR22845:SF5
organism: Bos taurus

Ub
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P14635 55
type: UnificationXref
id: P14635
db: uniprot

uniprot P10361 145
type: UnificationXref
id: P10361
db: uniprot

uniprot F1MD32 170
type: UnificationXref
id: F1MD32
db: uniprot

Mdm2 s84 sa11 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.217183888389608
comment: MODIFICATION_RESIDUE_NAME=

Cyclin B
type: Protein
entity reference: Cyclin B
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa164 425
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re26 489
type: Stoichiometry
physical entity: a101_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 488
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

Ribonucleotide reductase regulatory subunit M2
type: DnaReference
organism: Canis lupus familiaris

uniprot Q14191 114
type: UnificationXref
id: Q14191
db: uniprot

uniprot Q9JHD1 304
type: UnificationXref
id: Q9JHD1
db: uniprot

G1/S-specific cyclin-E1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot Q61457 23
organism: Mus musculus

Complex (GADD45/B99)
type: Complex
component stoichiometry: B99 s29 sa172 STOICHIOMETRY ID COMPLEX
component stoichiometry: GADD45 s28 sa171 STOICHIOMETRY ID COMPLEX
component: B99
component: GADD45
feature: COMPLEX BINDING FEATURE s114 csa8 444
feature: COMPLEX BINDING FEATURE s114 csa8 442

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P32871 355
xref: PTHR10048:SF107
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re63 530
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re63 531
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PiP3-RIGHT__PiP2-_re20
controller: PTEN

uniprot P42524 60
type: UnificationXref
id: P42524
db: uniprot

G2 and S phase-expressed protein 1
type: ProteinReference
xref: PTHR21584:SF10
xref: uniprot Q8R080 49
organism: Mus musculus

GADD45B isoform 2
type: ProteinReference
xref: PTHR10411:SF5
xref: uniprot H2R6I0 247
organism: Pan troglodytes

Serpin family E member 1
type: DnaReference
xref: PTHR11461:SF49
organism: Bos taurus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q60823 293
organism: Mus musculus

Protein Mdm4
type: ProteinReference
xref: uniprot F7GQ86 223
organism: Macaca mulatta

uniprot P56180 198
type: UnificationXref
id: P56180
db: uniprot

TRANSCRIPTION_LEFT__BAI_1-RIGHT__BAI1-_re101
type: TemplateReaction
product: BAI1
xref: TRANSCRIPTION
participant: BAI-1
participant: BAI1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Growth arrest and DNA damage-inducible protein GADD45 beta
type: ProteinReference
xref: PTHR10411:SF5
xref: uniprot P22339 251
organism: Mus musculus

Insulin-like growth factor-binding protein 3
type: DnaRegionReference
member entity reference: Insulin-like growth factor-binding protein 3
member entity reference: IGFBP3 isoform 2
member entity reference: Uncharacterized protein
xref: G04691
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.IGF_minus_BP3
comment: ENTITY_REFERENCE_NOTES=Long Name: Insulin-like growth factor-binding protein 3 Synonym: IBP3,IGFBP3 Accession: G04691
display name: IGF-BP3

uniprot B7QGY5 309
type: UnificationXref
id: B7QGY5
db: uniprot

Growth arrest and DNA-damage-inducible, alpha, a
type: ProteinReference
xref: uniprot F1R8Z0 242
organism: Danio rerio

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Inhibition of Angiogenesis and Metastasis
controller: Maspin

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 312

TRANSCRIPTION_LEFT__PAG608-RIGHT__PAG608-_re100
type: TemplateReaction
product: PAG608
xref: TRANSCRIPTION
participant: PAG608
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot A0A2I3TN41 95
type: UnificationXref
id: A0A2I3TN41
db: uniprot

uniprot A0A0G2K344 346
type: UnificationXref
id: A0A0G2K344
db: uniprot

Chk2
type: Protein
entity reference: Chk2
feature: Chk2 s40 sa22 rs1
comment: SPECIES_TYPE=PROTEIN

PTHR46778:SF1
type: RelationshipXref
id: PTHR46778:SF1
db: PANTHER Family
relationship type: By Homology

TRANSLATION_LEFT__Mdm2-RIGHT__Mdm2-_re68
type: TemplateReaction
product: Mdm2
xref: TRANSLATION
participant: Mdm2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot F1PQ93 263
type: UnificationXref
id: F1PQ93
db: uniprot

uniprot O09106 43
type: UnificationXref
id: O09106
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot E1B8D6 27
organism: Bos taurus

Metastasis associated 1 family member 2
type: ProteinReference
xref: PTHR10865:SF4
xref: uniprot E2R655 88
organism: Canis lupus familiaris

TNF receptor-associated factor
type: ProteinReference
xref: PTHR10131:SF21
xref: uniprot H2QY73 154
organism: Pan troglodytes

Apoptosis regulator BAX
type: DnaReference
xref: PTHR11256:SF42
organism: Mus musculus

uniprot Q03306 99
type: UnificationXref
id: Q03306
db: uniprot

Wildtype p53-induced gene
type: DnaRegionReference
member entity reference: ZMAT3 isoform 1
member entity reference: Zinc finger matrin-type 3
member entity reference: Zinc finger matrin-type protein 3
member entity reference: Uncharacterized protein
xref: G04690
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.PAG608
comment: ENTITY_REFERENCE_NOTES=Long Name: Wildtype p53-induced gene Synonym: WIG1,p53-activated gene 608 Accession: G04690
display name: PAG608

P53AIP1
type: DnaRegion
comment: SPECIES_TYPE=GENE

uniprot Q803G3 335
type: UnificationXref
id: Q803G3
db: uniprot

uniprot Q9NYZ3 50
type: UnificationXref
id: Q9NYZ3
db: uniprot

Histone deacetylase 1
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot O09106 43
organism: Mus musculus

p53 apoptosis effector related to PMP-22
type: DnaRegionReference
member entity reference: PERP, TP53 apoptosis effector
member entity reference: Uncharacterized protein
member entity reference: p53 apoptosis effector related to PMP-22
xref: G01565
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.PERP
comment: ENTITY_REFERENCE_NOTES=Long Name: p53 apoptosis effector related to PMP-22 Synonym: Synonym not specified Accession: G01565
display name: PERP

CREB-binding protein
type: ProteinReference
xref: uniprot Q92793 183
xref: PTHR13808:SF34
organism: Homo sapiens

uniprot Q9JKK8 83
type: UnificationXref
id: Q9JKK8
db: uniprot

uniprot O74630 74
type: UnificationXref
id: O74630
db: uniprot

Small ubiquitin-like modifier 2
type: ProteinReference
xref: uniprot H2RG60 385
organism: Pan troglodytes

Histone acetyltransferase HAC2
type: ProteinReference
xref: PTHR13808:SF43
xref: uniprot Q9FYH1 186
organism: Arabidopsis thaliana

uniprot P97377 373
type: UnificationXref
id: P97377
db: uniprot

uniprot Q09472 30
type: UnificationXref
id: Q09472
db: uniprot

CD82 antigen
type: DnaReference
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re116 473
type: Stoichiometry
physical entity: Sumo-1 ligase
stoichiometric coefficient: 1.0

G2/mitotic-specific cyclin-B
type: ProteinReference
xref: uniprot P20439 56
xref: PTHR10177:SF347
organism: Drosophila melanogaster

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6QE96 279
xref: PTHR24356:SF176
organism: Macaca mulatta

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__Cdc2-_Cdc25C-_Cyclin_B-RIGHT__Complex__Cdc25C_Cyclin_B__Cdc2_-_re29
control type: INHIBITION
controller: Reprimo

PARTICIPANT STOICHIOMETRY re116 474
type: Stoichiometry
physical entity: Sumo-1 ligase
stoichiometric coefficient: 1.0

TRANSCRIPTION
type: InteractionVocabulary

Feedback loops
type: Pathway

Tumor necrosis factor receptor superfamily member 6
type: DnaReference
xref: PTHR46874:SF1
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1PRG4 277
xref: PTHR24356:SF176
organism: Canis lupus familiaris

uniprot F1PRG4 277
type: UnificationXref
id: F1PRG4
db: uniprot

Serine/threonine-protein kinase PKH3
type: ProteinReference
xref: uniprot Q03306 99
organism: Saccharomyces cerevisiae

Cyclin-dependent kinase 1
type: ProteinReference
xref: uniprot P04551 363
organism: Schizosaccharomyces pombe

Small ubiquitin-related modifier
type: ProteinReference
xref: uniprot F7ATG0 384
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re122 459
type: Stoichiometry
physical entity: PCAF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re122 458
type: Stoichiometry
physical entity: PCAF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 466
type: Stoichiometry
physical entity: Complex (GADD45/B99)
stoichiometric coefficient: 1.0

Tumor necrosis factor receptor superfamily member 10B
type: DnaReference
xref: PTHR46330:SF1
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re30 464
type: Stoichiometry
physical entity: GADD45
stoichiometric coefficient: 1.0

Tumor necrosis factor receptor superfamily member 10A
type: DnaReference
xref: PTHR46330:SF2
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re30 465
type: Stoichiometry
physical entity: B99
stoichiometric coefficient: 1.0

G04689
type: UnificationXref
id: G04689
db: PANTHER Pathway Component

Complex (P21/Cdk2/ Cyclin E)
type: Complex
component stoichiometry: Cyclin E s24 sa168 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cdk2 s23 sa167 STOICHIOMETRY ID COMPLEX
component stoichiometry: P21 s22 sa166 STOICHIOMETRY ID COMPLEX
component: Cyclin E
component: P21
component: Cdk2
feature: COMPLEX BINDING FEATURE s98 csa6 432
feature: COMPLEX BINDING FEATURE s98 csa6 436
feature: COMPLEX BINDING FEATURE s98 csa6 434

G04690
type: UnificationXref
id: G04690
db: PANTHER Pathway Component

G04691
type: UnificationXref
id: G04691
db: PANTHER Pathway Component

Small ubiquitin-related modifier 2
type: ProteinReference
xref: uniprot Q28H04 392
organism: Xenopus tropicalis

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__HDAC1-RIGHT__HDAC1-_re120
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

TRANSCRIPTION_LEFT__14_3_3-RIGHT__14_3_3-_re77
type: TemplateReaction
product: 14-3-3
xref: TRANSCRIPTION
participant: 14-3-3
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot O95257 250
type: UnificationXref
id: O95257
db: uniprot

G04692
type: UnificationXref
id: G04692
db: PANTHER Pathway Component

G04694
type: UnificationXref
id: G04694
db: PANTHER Pathway Component

G04697
type: UnificationXref
id: G04697
db: PANTHER Pathway Component

G04696
type: UnificationXref
id: G04696
db: PANTHER Pathway Component

uniprot F7CP86 316
type: UnificationXref
id: F7CP86
db: uniprot

G04699
type: UnificationXref
id: G04699
db: PANTHER Pathway Component

uniprot F6T7D0 28
type: UnificationXref
id: F6T7D0
db: uniprot

Cyclin-dependent kinase inhibitor 1
type: ProteinReference
xref: uniprot P39689 340
xref: PTHR46778:SF1
organism: Mus musculus

Cell division related protein kinase 2, putative
type: ProteinReference
xref: uniprot Q38BA2 374
organism: Trypanosoma brucei

uniprot A0A1D5Q1X3 232
type: UnificationXref
id: A0A1D5Q1X3
db: uniprot

PP2A
type: Protein
entity reference: PP2A
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

ATR serine/threonine kinase
type: ProteinReference
xref: PTHR11139:SF69
xref: uniprot A0A3Q1M8V1 64
organism: Bos taurus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__BAI_1-RIGHT__BAI1-_re101
control type: ACTIVATION
controller: p53

Small ubiquitin-related modifier 3
type: ProteinReference
xref: uniprot P55854 386
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: PUMA

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re19 500
type: Stoichiometry
physical entity: PiP3
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase subunit M2
type: DnaReference
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot K7CDC2 286
xref: PTHR24356:SF176
organism: Pan troglodytes

p53-inducible ribonucleotide reductase small subunit 2-like
type: DnaRegionReference
member entity reference: Ribonucleotide reductase M2 polypeptide
member entity reference: Uncharacterized protein
member entity reference: Ribonucleoside-diphosphate reductase subunit M2
member entity reference: Ribonucleotide reductase regulatory subunit M2
xref: G04692
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.R2
comment: ENTITY_REFERENCE_NOTES=Long Name: p53-inducible ribonucleotide reductase small subunit 2-like Synonym: RRM2B,Ribonucleotide reductase, M2 B,p53R2 Accession: G04692
display name: R2

Akt
type: ProteinReference
xref: P01486
standard name: protein kinase B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.Akt
comment: ENTITY_REFERENCE_NOTES=Long Name: V-akt murine thymoma viral oncogene homolog Synonym: PKB,Protein kinase B Accession: P01486 Pathway Link: P00033|P00894|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04641|p53 pathway by glucose deprivation*P04398|P04665|p53 pathway feedback loops 2
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-1

E3 ubiquitin-protein ligase SIAH1
type: DnaReference
xref: PTHR45877:SF1
organism: Homo sapiens

Cyclin-dependent kinase 2
type: ProteinReference
xref: uniprot Q5E9Y0 236
xref: PTHR24056:SF254
organism: Bos taurus

GADD45
type: RnaRegion
comment: SPECIES_TYPE=RNA

UNKNOWN_TRANSITION_LEFT__p53-RIGHT__p53-_re113
type: Conversion
conversion direction: REVERSIBLE
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 479
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 480
left: p53
interaction type: UNKNOWN_TRANSITION
right: p53

Histone deacetylase 1
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot Q32PJ8 46
organism: Bos taurus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Cyclin_G-RIGHT__Cyclin_G-_re103
control type: ACTIVATION
controller: p53

PERP
type: RnaRegion
comment: SPECIES_TYPE=RNA

Cyclin-dependent kinase 1
type: ProteinReference
xref: uniprot P13863 366
organism: Gallus gallus

Small ubiquitin-related modifier 1
type: ProteinReference
xref: uniprot Q6DEP7 398
organism: Xenopus tropicalis

uniprot H2RFJ9 338
type: UnificationXref
id: H2RFJ9
db: uniprot

uniprot Q7ZU21 63
type: UnificationXref
id: Q7ZU21
db: uniprot

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot A0A0G2JVC1 218
organism: Rattus norvegicus

PTEN
type: RnaRegion
comment: SPECIES_TYPE=RNA

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Macaca mulatta

TRANSCRIPTION_LEFT__Siah-RIGHT__Siah-_re97
type: TemplateReaction
product: Siah
xref: TRANSCRIPTION
participant: Siah
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

GADD45 s28 sa171 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GADD45
stoichiometric coefficient: 1.0

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P10361 145
organism: Rattus norvegicus

Thrombospondin 1
type: DnaReference
xref: PTHR10199:SF78
organism: Xenopus tropicalis

E3 ubiquitin-protein ligase SIAH1A
type: DnaReference
xref: PTHR45877:SF1
organism: Mus musculus

Tumor protein p73
type: ProteinReference
xref: uniprot O15350 141
xref: PTHR11447:SF21
organism: Homo sapiens

E3 ubiquitin-protein ligase SIAH1B
type: DnaReference
xref: PTHR45877:SF1
organism: Mus musculus

KAI
type: RnaRegion
comment: SPECIES_TYPE=RNA

Mdm2 s139 sa61 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.217183888389608
comment: MODIFICATION_RESIDUE_NAME=

IDA
type: EvidenceCodeVocabulary

Werner syndrome ATP-dependent helicase
type: ProteinReference
xref: uniprot Q14191 114
organism: Homo sapiens

uniprot Q1LZG6 62
type: UnificationXref
id: Q1LZG6
db: uniprot

PTHR18860:SF14
type: RelationshipXref
id: PTHR18860:SF14
db: PANTHER Family
relationship type: By Homology

Complex (P110alpha/PI3-K)
type: Complex
component stoichiometry: P110alpha s18 sa161 STOICHIOMETRY ID COMPLEX
component stoichiometry: PI3 K s19 sa162 STOICHIOMETRY ID COMPLEX
component: PI3-K
component: P110alpha
feature: COMPLEX BINDING FEATURE s81 csa4 414
feature: COMPLEX BINDING FEATURE s81 csa4 416

CREB-binding protein isoform a
type: ProteinReference
xref: uniprot F6RRA8 172
xref: PTHR13808:SF34
organism: Macaca mulatta

WRN
type: Protein
entity reference: WRN
comment: SPECIES_TYPE=PROTEIN

TRANSLATION_LEFT__p110alpha-RIGHT__P110alpha-_re72
type: TemplateReaction
product: P110alpha
xref: TRANSLATION
participant: P110alpha
participant: p110alpha
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Inhibition of Angiogenesis and Metastasis
controller: BAI1

CBP
type: ProteinReference
xref: P04623
standard name: CREB binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.CBP
comment: ENTITY_REFERENCE_NOTES=Long Name: CREB binding protein Synonym: CREB binding protein Accession: P04623
member entity reference: Histone acetyltransferase HAC1
member entity reference: Uncharacterized protein
member entity reference: Protein cbp-1
member entity reference: Histone acetyltransferase p300
member entity reference: CREB binding protein
member entity reference: Histone acetyltransferase HAC2
member entity reference: CREB-binding protein isoform a
member entity reference: CREB-binding protein
member entity reference: Histone acetyltransferase
member entity reference: Histone acetyltransferase HAC5
member entity reference: E1A binding protein p300
member entity reference: Histone acetyltransferase HAC4
member entity reference: Histone acetyltransferase KAT6B
member entity reference: Histone acetyltransferase HAC12

TRANSLATION_LEFT__p53-RIGHT__p53-_re66
type: TemplateReaction
product: p53
xref: TRANSLATION
participant: p53
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

Reprimo
type: RnaRegion
comment: SPECIES_TYPE=RNA

Cyclin-dependent kinase 2
type: ProteinReference
xref: uniprot P24941 235
xref: PTHR24056:SF254
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re125 453
type: Stoichiometry
physical entity: SIRT-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re125 452
type: Stoichiometry
physical entity: SIRT-1
stoichiometric coefficient: 1.0

PTHR11139:SF72
type: RelationshipXref
id: PTHR11139:SF72
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__14_3_3-RIGHT__14_3_3-_re77
control type: ACTIVATION
controller: p53

14-3-3
type: Protein
entity reference: 14-3-3
comment: SPECIES_TYPE=PROTEIN

E2F-1
type: ProteinReference
xref: P04627
standard name: E2F transcription factor 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.E2F_minus_1
comment: ENTITY_REFERENCE_NOTES=Long Name: E2F transcription factor 1 Synonym: Transcription factor E2F Accession: P04627
member entity reference: Transcription factor E2f1
member entity reference: E2F transcription factor 3

Tetraspanin
type: DnaReference
xref: PTHR19282:SF44
organism: Macaca mulatta

PTHR11139:SF69
type: RelationshipXref
id: PTHR11139:SF69
db: PANTHER Family
relationship type: By Homology

uniprot Q12236 101
type: UnificationXref
id: Q12236
db: uniprot

14-3-3
type: DnaRegion
entity reference: 14-3-3 sigma
comment: SPECIES_TYPE=GENE

BCL2-associated X, apoptosis regulator a
type: DnaReference
organism: Danio rerio

acetylated residue
type: SequenceModificationVocabulary
xref: 00394
comment: DATA_SOURCE=CellDesigner

uniprot Q32PJ8 46
type: UnificationXref
id: Q32PJ8
db: uniprot

HDAC1
type: Protein
entity reference: HDAC1
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa158 449
comment: SPECIES_TYPE=PROTEIN

Promyelocytic leukemia protein
type: DnaRegionReference
member entity reference: PML isoform 6
member entity reference: Protein PML
member entity reference: Protein PML isoform 1
xref: G04701
comment: ENTITY_REFERENCE_NOTES=Long Name: PML Synonym: Synonym not specified Accession: G04701
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.PML
display name: PML

uniprot P47196 290
type: UnificationXref
id: P47196
db: uniprot

uniprot Q5XIN1 231
type: UnificationXref
id: Q5XIN1
db: uniprot

Growth arrest and DNA damage-inducible protein GADD45 beta
type: ProteinReference
xref: PTHR10411:SF5
xref: uniprot F7EBI6 244
organism: Macaca mulatta

uniprot P06493 364
type: UnificationXref
id: P06493
db: uniprot

PTHR11447:SF21
type: RelationshipXref
id: PTHR11447:SF21
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Cdc2-_Cdc25C-_Cyclin_B-RIGHT__Complex__Cdc25C_Cyclin_B__Cdc2_-_re29
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 484
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 482
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 481
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 483
left: Cdc2
left: Cdc25C
left: Cyclin B
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cdc25C/Cyclin B/ Cdc2)

Zinc finger matrin-type protein 3
type: DnaReference
organism: Homo sapiens

uniprot Q9H3D4 150
type: UnificationXref
id: Q9H3D4
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot E9QG65 133
organism: Danio rerio

uniprot P47794 21
type: UnificationXref
id: P47794
db: uniprot

STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 525
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 524
left: Mdm2
interaction type: STATE_TRANSITION
right: Mdm2

Protein PML
type: DnaReference
organism: Mus musculus

TNF receptor-associated factor
type: ProteinReference
xref: PTHR10131:SF21
xref: uniprot J9NS71 155
organism: Canis lupus familiaris

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: NOXA

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q17941 292
organism: Caenorhabditis elegans

uniprot Q63699 377
type: UnificationXref
id: Q63699
db: uniprot

Metastasis-associated protein MTA2
type: ProteinReference
xref: PTHR10865:SF4
xref: uniprot Q9R190 94
organism: Mus musculus

Mdm2 s141 sa100 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.217183888389608
comment: MODIFICATION_RESIDUE_NAME=

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Sin3-RIGHT__Sin3-_re121
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

uniprot H9FVU5 354
type: UnificationXref
id: H9FVU5
db: uniprot

p53
type: Protein
entity reference: p53
feature: ser, thr p53 s5 sa3 rs2
feature: lys p53 s5 sa3 rs1
comment: SPECIES_TYPE=PROTEIN

PCAF
type: ProteinReference
xref: P04629
standard name: p300/CBP-associated factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: p300/CBP-associated factor Synonym: P/CAF Accession: P04629
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.PCAF
member entity reference: Lysine acetyltransferase 2B
member entity reference: Histone acetyltransferase
member entity reference: Histone acetyltransferase KAT2B

MODULATION
type: Control
xref: MODULATION
controller: Insulin IGF pathway_BR_PKB cascade

uniprot Q29537 149
type: UnificationXref
id: Q29537
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 346
xref: PTHR10048:SF107
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re57 545
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re57 546
type: Stoichiometry
physical entity: Reactive oxygen species
stoichiometric coefficient: 1.0

uniprot O75293 249
type: UnificationXref
id: O75293
db: uniprot

uniprot A0A1D5RJ75 380
type: UnificationXref
id: A0A1D5RJ75
db: uniprot

uniprot Q567Y8 331
type: UnificationXref
id: Q567Y8
db: uniprot

Serine-protein kinase ATM
type: ProteinReference
xref: PTHR11139:SF72
xref: uniprot F6ZIB3 70
organism: Macaca mulatta

uniprot F1N736 222
type: UnificationXref
id: F1N736
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot Q8T9S7 202
organism: Dictyostelium discoideum

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__PML-RIGHT__PML-_re114
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

ATM ATR s42 sa12 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Chk2 s40 sa22 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ncbitaxon 9615 42
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot O35618 227
type: UnificationXref
id: O35618
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Sin3-_HDAC1-RIGHT__Complex__Sin3_HDAC1_-_re15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 511
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 509
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 510
left: HDAC1
left: Sin3
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Sin3/HDAC1)

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__P53AIP1-RIGHT__P53AIP1-_re93
control type: ACTIVATION
controller: p53

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F1Q3M8 349
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re17 505
type: Stoichiometry
physical entity: Complex (ARF/E2F-1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 504
type: Stoichiometry
physical entity: ARF
stoichiometric coefficient: 1.0

Insulin-like growth factor-binding protein 3
type: DnaReference
organism: Homo sapiens

lys p53 s31 sa174 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys p53 s31 sa174 rs1 lys
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=lys
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot C3XQF4 311
xref: PTHR45619:SF12
organism: Branchiostoma floridae

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H9FVU5 354
xref: PTHR10048:SF107
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re17 503
type: Stoichiometry
physical entity: E2F-1
stoichiometric coefficient: 1.0

uniprot Q9JJP2 151
type: UnificationXref
id: Q9JJP2
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot Q8WYB5 182
type: UnificationXref
id: Q8WYB5
db: uniprot

p48
type: DnaRegion
entity reference: DNA damage-binding protein 2
comment: SPECIES_TYPE=GENE

uniprot F1MDX9 191
type: UnificationXref
id: F1MDX9
db: uniprot

TRANSCRIPTION_LEFT__BAX-RIGHT__BAX-_re91
type: TemplateReaction
product: BAX
xref: TRANSCRIPTION
participant: BAX
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot Q6YKA4 128
type: UnificationXref
id: Q6YKA4
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: UNKNOWN_TRANSITION_LEFT__p53-RIGHT__p53-_re113
controller: Sumo-1 ligase

Growth arrest and DNA damage-inducible protein GADD45 beta
type: DnaReference
xref: PTHR10411:SF5
organism: Bos taurus

uniprot P63165 390
type: UnificationXref
id: P63165
db: uniprot

PTHR10199:SF78
type: RelationshipXref
id: PTHR10199:SF78
db: PANTHER Family
relationship type: By Homology

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 66

G2 and S phase-expressed protein 1
type: ProteinReference
xref: PTHR21584:SF10
xref: uniprot Q9NYZ3 50
organism: Homo sapiens

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
organism: Dictyostelium discoideum

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: KILLER/DRS

Growth arrest and DNA damage-inducible protein GADD45 beta
type: DnaReference
xref: PTHR10411:SF5
organism: Macaca mulatta

CBP
type: Protein
entity reference: CBP
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

IP16020p
type: DnaReference
xref: PTHR12305:SF81
organism: Drosophila melanogaster

PTHR11461:SF55
type: RelationshipXref
id: PTHR11461:SF55
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__PML-RIGHT__PML-_re114
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re114 478
participant stoichiometry: PARTICIPANT STOICHIOMETRY re114 477
left: PML
interaction type: STATE_TRANSITION
right: PML

uniprot B1H2U0 190
type: UnificationXref
id: B1H2U0
db: uniprot

TNF receptor superfamily member 10a
type: DnaReference
xref: PTHR46330:SF2
organism: Pan troglodytes

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F1PL57 135
organism: Canis lupus familiaris

TNF receptor superfamily member 10b
type: DnaReference
xref: PTHR46330:SF1
organism: Pan troglodytes

GD-AIF
type: RnaRegion
comment: SPECIES_TYPE=RNA

B99
type: RnaRegion
comment: SPECIES_TYPE=RNA

uniprot F6UDV6 173
type: UnificationXref
id: F6UDV6
db: uniprot

R2
type: DnaRegion
entity reference: p53-inducible ribonucleotide reductase small subunit 2-like
comment: SPECIES_TYPE=GENE

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6SW23 350
organism: Gallus gallus

STATE_TRANSITION_LEFT__HMG1-RIGHT__HMG1-_re115
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re115 476
participant stoichiometry: PARTICIPANT STOICHIOMETRY re115 475
left: HMG1
interaction type: STATE_TRANSITION
right: HMG1

PAG608
type: RnaRegion
comment: SPECIES_TYPE=RNA

Apoptosis regulator BAX
type: DnaReference
xref: PTHR11256:SF42
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V3X3 359
organism: Monodelphis domestica

PTHR11461:SF49
type: RelationshipXref
id: PTHR11461:SF49
db: PANTHER Family
relationship type: By Homology

DNA damage-binding protein 2
type: DnaReference
organism: Mus musculus

GADD45A isoform 1
type: DnaReference
xref: PTHR10411:SF3
organism: Pan troglodytes

uniprot P55854 386
type: UnificationXref
id: P55854
db: uniprot

GADD45G isoform 1
type: ProteinReference
xref: PTHR10411:SF4
xref: uniprot H2QXF6 246
organism: Pan troglodytes

uniprot F7EC89 90
type: UnificationXref
id: F7EC89
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR15169:SF0
organism: Macaca mulatta

TRANSCRIPTION_LEFT__P53AIP1-RIGHT__P53AIP1-_re93
type: TemplateReaction
product: P53AIP1
xref: TRANSCRIPTION
participant: P53AIP1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Cyclin-dependent kinase inhibitor 1
type: ProteinReference
xref: uniprot P38936 339
organism: Homo sapiens

B99 s29 sa172 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: B99
stoichiometric coefficient: 1.0

Uncharacterized protein
type: DnaReference
xref: PTHR21584:SF10
organism: Macaca mulatta

Metastasis associated 1-like, isoform D
type: ProteinReference
xref: uniprot A0A0B4KG70 85
organism: Drosophila melanogaster

Kangai 1
type: DnaRegionReference
member entity reference: Tetraspanin
member entity reference: CD82 antigen
xref: G04704
comment: ENTITY_REFERENCE_NOTES=Long Name: Kangai 1 Synonym: CD82,Leukocyte surface antigen R2,SAR2,ST6,Suppressor of tumorigenicity 6 Accession: G04704
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.KAI
display name: KAI

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q9XF67 107
xref: PTHR24356:SF163
organism: Arabidopsis thaliana

Small ubiquitin-related modifier 1
type: ProteinReference
xref: uniprot Q8QGH2 403
organism: Gallus gallus

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 77

uniprot Q9Z111 260
type: UnificationXref
id: Q9Z111
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 57

uniprot A0A1D5PLS6 300
type: UnificationXref
id: A0A1D5PLS6
db: uniprot

G2/mitotic-specific cyclin-B1
type: ProteinReference
xref: uniprot F7GX97 53
xref: PTHR10177:SF193
organism: Macaca mulatta

GADD45
type: ProteinReference
xref: P04626
standard name: Growth arrest and DNA-damage-inducible, alpha
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Growth arrest-and DNA-damage-inducible, alpha Synonym: Synonym not specified Accession: P04626
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.GADD45
member entity reference: Growth arrest and DNA damage-inducible protein GADD45 gamma
member entity reference: Growth arrest and DNA damage-inducible protein GADD45 alpha
member entity reference: Growth arrest and DNA-damage-inducible 45 beta
member entity reference: Growth arrest and DNA damage-inducible protein GADD45 beta
member entity reference: Growth arrest and DNA-damage-inducible, alpha, a
member entity reference: GADD45G isoform 1
member entity reference: Cytokine-responsive protein CR6
member entity reference: Growth arrest and DNA damage inducible beta
member entity reference: Uncharacterized protein
member entity reference: Growth arrest and DNA damage inducible gamma
member entity reference: GADD45A isoform 1
member entity reference: Growth arrest and DNA damage-inducible gamma
member entity reference: GADD45B isoform 2

uniprot Q9FWQ5 185
type: UnificationXref
id: Q9FWQ5
db: uniprot

Cyclin dependent kinase 1
type: ProteinReference
xref: uniprot F7BI12 360
organism: Ornithorhynchus anatinus

14-3-3 protein sigma
type: ProteinReference
xref: uniprot G7MHX1 265
xref: PTHR18860:SF14
organism: Macaca mulatta

BAI-1
type: DnaRegion
entity reference: BAI-1
comment: SPECIES_TYPE=GENE

Tumor protein 63 (p63)
type: DnaReference
xref: PTHR11447:SF8
organism: Gallus gallus

uniprot P48463 322
type: UnificationXref
id: P48463
db: uniprot

TRANSCRIPTION_LEFT__Maspin-RIGHT__Maspin-_re107
type: TemplateReaction
product: Maspin
xref: TRANSCRIPTION
participant: Maspin
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

NOXA
type: DnaRegionReference
member entity reference: Apoptosis-inducing factor 2
member entity reference: Phorbol-12-myristate-13-acetate-induced protein 1
member entity reference: AIFM2 isoform 1
member entity reference: Apoptosis-inducing factor, mitochondria-associated 2
xref: G01572
comment: ENTITY_REFERENCE_NOTES=Long Name: NOXA Synonym: Synonym not specified Accession: G01572
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.NOXA

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 372

PIDD
type: DnaRegion
comment: SPECIES_TYPE=GENE

Adhesion G protein-coupled receptor B2
type: DnaReference
organism: Bos taurus

TRANSCRIPTION_LEFT__Cyclin_G-RIGHT__Cyclin_G-_re103
type: TemplateReaction
product: Cyclin G
xref: TRANSCRIPTION
participant: Cyclin G
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

G2/mitotic-specific cyclin-B
type: ProteinReference
xref: uniprot P42524 60
xref: PTHR10177:SF347
organism: Dictyostelium discoideum

PTHR11256:SF42
type: RelationshipXref
id: PTHR11256:SF42
db: PANTHER Family
relationship type: By Homology

uniprot P39951 369
type: UnificationXref
id: P39951
db: uniprot

uniprot A0A3Q1LU60 169
type: UnificationXref
id: A0A3Q1LU60
db: uniprot

Protein PML
type: DnaReference
xref: PTHR25462:SF241
organism: Homo sapiens

UNKNOWN_TRANSITION_LEFT__Inhibition_of_Angiogenesis_and_Metastasis-RIGHT__Tumor_suppression-_re9
type: Interaction
xref: UNKNOWN TRANSITION
participant: Tumor suppression
participant: Inhibition of Angiogenesis and Metastasis

Cdk2 s20 sa169 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cdk2
stoichiometric coefficient: 1.0

Cell division cycle 25C
type: ProteinReference
xref: PTHR10828:SF64
xref: uniprot F7B6Y3 211
organism: Xenopus tropicalis

uniprot E7EXT6 275
type: UnificationXref
id: E7EXT6
db: uniprot

uniprot Q923E4 344
type: UnificationXref
id: Q923E4
db: uniprot

uniprot A0A3Q1NH21 272
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 36

Growth arrest and DNA damage-inducible protein GADD45 gamma
type: ProteinReference
xref: PTHR10411:SF4
xref: uniprot Q9Z111 260
organism: Mus musculus

Cell division control protein 2 homolog
type: ProteinReference
xref: uniprot P61075 371
organism: Plasmodium falciparum

TRAF
type: ProteinReference
xref: P04620
standard name: TNF receptor-associated factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: TRAF Synonym: TRAP Accession: P04620
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.TRAF
member entity reference: TNF receptor-associated factor
member entity reference: TNF receptor-associated factor 2
member entity reference: GH01161p

uniprot P20439 56
type: UnificationXref
id: P20439
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR11256:SF42
organism: Macaca mulatta

uniprot F6V3X3 359
type: UnificationXref
id: F6V3X3
db: uniprot

Apoptotic protease activating factor 1
type: DnaRegionReference
member entity reference: Apoptotic protease-activating factor 1
xref: G04703
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.Apaf
comment: ENTITY_REFERENCE_NOTES=Long Name: Apoptotic protease activating factor 1 Synonym: Synonym not specified Accession: G04703
display name: Apaf

uniprot Q7KMQ6 201
type: UnificationXref
id: Q7KMQ6
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: G1-S
controller: Complex (Cdk2/Cyclin E)

Zinc finger matrin-type protein 3
type: DnaReference
organism: Bos taurus

uniprot P02340 143
type: UnificationXref
id: P02340
db: uniprot

Cyclin-dependent kinase 4 inhibitor D
type: DnaReference
organism: Macaca mulatta

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF188
xref: uniprot J9NUI0 41
organism: Canis lupus familiaris

TRANSCRIPTION_LEFT__GADD45-RIGHT__GADD45-_re81
type: TemplateReaction
product: GADD45
xref: TRANSCRIPTION
participant: GADD45
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

ncbitaxon 7739 312
type: UnificationXref
id: 7739
db: ncbitaxon

p53
type: Protein
entity reference: p53
feature: lys p53 s1 sa14 rs1
feature: ser, thr p53 s1 sa14 rs2
comment: SPECIES_TYPE=PROTEIN

uniprot Q1RMW3 93
type: UnificationXref
id: Q1RMW3
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A2I3T7A8 348
xref: PTHR10048:SF107
organism: Pan troglodytes

Cyclin-dependent kinase inhibitor 1
type: ProteinReference
xref: uniprot F7EEK4 337
organism: Macaca mulatta

Sin3
type: Protein
entity reference: Sin3
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa157 447
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re27 485
type: Stoichiometry
physical entity: P21
stoichiometric coefficient: 1.0

uniprot A0A2I3T9Y4 271
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

Maspin
type: RnaRegion
comment: SPECIES_TYPE=RNA

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re27 486
type: Stoichiometry
physical entity: Complex (Cdk2/Cyclin E)
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7E5M4 317
xref: PTHR45619:SF44
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY re27 487
type: Stoichiometry
physical entity: Complex (P21/Cdk2/ Cyclin E)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot F6VBA7 193
organism: Macaca mulatta

KILLER/DRS
type: RnaRegion
comment: SPECIES_TYPE=RNA

Small ubiquitin-related modifier 1
type: ProteinReference
xref: uniprot P63165 390
organism: Homo sapiens

Small ubiquitin-related modifier 1
type: ProteinReference
xref: uniprot P63166 391
organism: Mus musculus

uniprot Q7PD38 334
type: UnificationXref
id: Q7PD38
db: uniprot

Phorbol-12-myristate-13-acetate-induced protein 1
type: DnaReference
organism: Homo sapiens

uniprot A0A2I3S626 86
type: UnificationXref
id: A0A2I3S626
db: uniprot

Histone acetyltransferase
type: ProteinReference
xref: uniprot A0A1D5PLS6 300
organism: Gallus gallus

PML isoform 6
type: DnaReference
xref: PTHR25462:SF241
organism: Pan troglodytes

G1/S-specific cyclin-E1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot P47794 21
organism: Danio rerio

Cell division control protein 2 homolog 2
type: ProteinReference
xref: uniprot Q57TX3 376
organism: Trypanosoma brucei

Adhesion G protein-coupled receptor B3
type: DnaReference
organism: Homo sapiens

Adhesion G protein-coupled receptor B2
type: DnaReference
organism: Homo sapiens

Adhesion G protein-coupled receptor B1
type: DnaReference
xref: PTHR12011:SF39
organism: Homo sapiens

High mobility group protein B1
type: ProteinReference
xref: uniprot P63159 127
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Inhibition of Angiogenesis and Metastasis
controller: GD-AIF

High mobility group protein B1
type: ProteinReference
xref: uniprot P63158 126
organism: Mus musculus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: PIDD

Protein Mdm4
type: ProteinReference
xref: uniprot O15151 226
organism: Homo sapiens

G2/mitotic-specific cyclin-B1
type: ProteinReference
xref: PTHR10177:SF193
xref: uniprot P14635 55
organism: Homo sapiens

uniprot G5E8H5 194
type: UnificationXref
id: G5E8H5
db: uniprot

PARTICIPANT STOICHIOMETRY re3 525
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

uniprot P42337 357
type: UnificationXref
id: P42337
db: uniprot

Cell Cycle Arrest
type: Pathway

PARTICIPANT STOICHIOMETRY re3 524
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

PTHR12346:SF2
type: RelationshipXref
id: PTHR12346:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q9W3I9 158
type: UnificationXref
id: Q9W3I9
db: uniprot

Uncharacterized protein
type: DnaReference
organism: Macaca mulatta

G04704
type: UnificationXref
id: G04704
db: PANTHER Pathway Component

G04705
type: UnificationXref
id: G04705
db: PANTHER Pathway Component

uniprot H2R6I0 247
type: UnificationXref
id: H2R6I0
db: uniprot

TRANSCRIPTION_LEFT__PIGs-RIGHT__PIGs-_re92
type: TemplateReaction
product: PIGs
xref: TRANSCRIPTION
participant: PIGs
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Protein cbp-1
type: ProteinReference
xref: uniprot P34545 178
xref: PTHR13808:SF1
organism: Caenorhabditis elegans

G04700
type: UnificationXref
id: G04700
db: PANTHER Pathway Component

G04701
type: UnificationXref
id: G04701
db: PANTHER Pathway Component

G04702
type: UnificationXref
id: G04702
db: PANTHER Pathway Component

G04703
type: UnificationXref
id: G04703
db: PANTHER Pathway Component

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31751 289
xref: PTHR24356:SF176
organism: Homo sapiens

HDAC1
type: Protein
entity reference: HDAC1
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re117 472
type: Stoichiometry
physical entity: WRN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re117 471
type: Stoichiometry
physical entity: WRN
stoichiometric coefficient: 1.0

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31750 288
xref: PTHR24356:SF171
organism: Mus musculus

uniprot Q03407 100
type: UnificationXref
id: Q03407
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 3

STATE_TRANSITION_LEFT__MTA2-RIGHT__MTA2-_re119
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re119 467
participant stoichiometry: PARTICIPANT STOICHIOMETRY re119 468
left: MTA2
interaction type: STATE_TRANSITION
right: MTA2

Metastasis associated 1 family member 2
type: ProteinReference
xref: uniprot Q1RMW3 93
xref: PTHR10865:SF4
organism: Bos taurus

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9WUA6 298
organism: Mus musculus

TRANSCRIPTION_LEFT__B99-RIGHT__B99-_re79
type: TemplateReaction
product: B99
xref: TRANSCRIPTION
participant: B99
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot P23804 229
type: UnificationXref
id: P23804
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31749 287
xref: PTHR24356:SF171
organism: Homo sapiens

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9W0V1 106
organism: Drosophila melanogaster

Cyclin-dependent kinase 4 inhibitor D
type: DnaReference
organism: Mus musculus

By Homology
type: RelationshipTypeVocabulary

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: PAG608

ATM/ATR
type: ProteinReference
xref: P01481
standard name: Ataxia telangiectasia mutated (ATM) and Rad3-related (ATR)
comment: ENTITY_REFERENCE_NOTES=Long Name: Ataxia telangiectasia mutated (ATM) and Rad3-related (ATR) Synonym: Synonym not specified Accession: P01481
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.ATM/ATR
member entity reference: Serine/threonine-protein kinase MEC1
member entity reference: Serine/threonine-protein kinase tel1
member entity reference: Serine/threonine-protein kinase TEL1
member entity reference: ATR serine/threonine kinase
member entity reference: Serine-protein kinase ATM
member entity reference: Protein kinase rad3
member entity reference: Serine/threonine-protein kinase ATR
member entity reference: UVSB
member entity reference: Uncharacterized protein
member entity reference: ATR isoform 1

uniprot Q6DHL4 399
type: UnificationXref
id: Q6DHL4
db: uniprot

uniprot F7H808 318
type: UnificationXref
id: F7H808
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot B1H2U0 190
xref: PTHR12305:SF81
organism: Xenopus tropicalis

E1A binding protein p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot H2QLS0 29
organism: Pan troglodytes

Cyclin-G1
type: DnaReference
xref: PTHR10177:SF59
organism: Bos taurus

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 310

uniprot O55173 98
type: UnificationXref
id: O55173
db: uniprot

Cyclin dependent kinase inhibitor 1A
type: ProteinReference
xref: uniprot H2RFJ9 338
xref: PTHR46778:SF1
organism: Pan troglodytes

uniprot Q57TX3 376
type: UnificationXref
id: Q57TX3
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Canis lupus familiaris

Putative tyrosine-protein phosphatase TPTE
type: DnaReference
organism: Homo sapiens

uniprot Q60953 118
type: UnificationXref
id: Q60953
db: uniprot

Reprimo
type: Protein
comment: SPECIES_TYPE=PROTEIN

Stratifin
type: ProteinReference
xref: uniprot F1PQ93 263
organism: Canis lupus familiaris

uniprot H2QY73 154
type: UnificationXref
id: H2QY73
db: uniprot

uniprot Q8UUX0 297
type: UnificationXref
id: Q8UUX0
db: uniprot

RAC serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q8INB9 296
organism: Drosophila melanogaster

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F1MD32 170
organism: Bos taurus

PIDD
type: RnaRegion
comment: SPECIES_TYPE=RNA

uniprot Q7QK56 294
type: UnificationXref
id: Q7QK56
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: Scotin

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Rattus norvegicus

Small ubiquitin-related modifier 2
type: ProteinReference
xref: uniprot Q6DHL4 399
organism: Danio rerio

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 14

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q6GLE6 332
xref: PTHR45619:SF44
organism: Xenopus tropicalis

p53
type: Protein
entity reference: p53
feature: ACTIVE 11
feature: lys p53 s65 sa45 rs1
feature: ser, thr p53 s65 sa45 rs2
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re2 526
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 527
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

Wip 1
type: RnaRegion
comment: SPECIES_TYPE=RNA

Tumor suppression
type: Pathway

B99
type: ProteinReference
xref: P04613
standard name: G2- and S- phase expressed gene 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.B99
comment: ENTITY_REFERENCE_NOTES=Long Name: G2- and S- phase expressed gene 1 Synonym: Gtse1 Accession: P04613
member entity reference: G-2 and S-phase expressed 1
member entity reference: Uncharacterized protein
member entity reference: G2 and S phase-expressed protein 1

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
name: Uncharacterized protein
xref: PTHR12305:SF81
organism: Canis lupus familiaris

14-3-3 sigma
type: DnaRegionReference
member entity reference: Similar to 14-3-3 protein sigma
member entity reference: 14-3-3 protein sigma
member entity reference: Stratifin
xref: G01576
comment: ENTITY_REFERENCE_NOTES=Long Name: 14-3-3 sigma Synonym: Synonym not specified Accession: G01576
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.14-3-3
display name: 14-3-3

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__p48-RIGHT__p48-_re106
control type: ACTIVATION
controller: p53

uniprot Q5E9D1 393
type: UnificationXref
id: Q5E9D1
db: uniprot

uniprot Q5XIF4 395
type: UnificationXref
id: Q5XIF4
db: uniprot

Chk2
type: ProteinReference
xref: P01484
standard name: Checkpoint kinase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Checkpoint kinase 2 Synonym: Synonym not specified Accession: P01484
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.Chk2
member entity reference: Serine/threonine-protein kinase Chk2
member entity reference: Uncharacterized protein
member entity reference: Checkpoint kinase 2
member entity reference: CHEK2 isoform 9
member entity reference: CHK2 checkpoint homolog (S. pombe), isoform CRA_a

Adhesion G protein-coupled receptor B2
type: DnaReference
organism: Mus musculus

ncbitaxon 39947 105
type: UnificationXref
id: 39947
db: ncbitaxon

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Homo sapiens

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__ARF-RIGHT__ARF-_re73
control type: ACTIVATION
controller: Oncogenes

Apoptotic protease-activating factor 1
type: DnaReference
xref: PTHR22845:SF5
organism: Mus musculus

Mdm2
type: ProteinReference
xref: P01483
standard name: Mouse double minute 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Mouse double minute 2 Synonym: Synonym not specified Accession: P01483 Pathway Link: P00033|P04496|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.Mdm2
member entity reference: E3 ubiquitin-protein ligase Mdm2
member entity reference: Protein Mdm4
member entity reference: MDM2 proto-oncogene

P21
type: Protein
entity reference: P21
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa166 433
comment: SPECIES_TYPE=PROTEIN

Cyclin E
type: ProteinReference
xref: P04610
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.Cyclin E
comment: ENTITY_REFERENCE_NOTES=
member entity reference: G1/S-specific cyclin-E1
member entity reference: Uncharacterized protein
member entity reference: CCNE1 isoform 1

uniprot F6R8N3 281
type: UnificationXref
id: F6R8N3
db: uniprot

uniprot Q17941 292
type: UnificationXref
id: Q17941
db: uniprot

HMG1
type: Protein
entity reference: HMG1
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Inhibition of Angiogenesis and Metastasis
controller: TSP1

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Wip1-RIGHT__Wip_1-_re104
control type: ACTIVATION
controller: p53

uniprot F6VXG1 351
type: UnificationXref
id: F6VXG1
db: uniprot

G2-M
type: Pathway

BAI1
type: RnaRegion
comment: SPECIES_TYPE=RNA

Uncharacterized protein
type: DnaReference
organism: Monodelphis domestica

Histone acetyltransferase p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot F6T7D0 28
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re14
controller: SIRT-1

uniprot F1MKA9 134
type: UnificationXref
id: F1MKA9
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: DNA Repair
controller: R2

uniprot K7DBC8 177
type: UnificationXref
id: K7DBC8
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Survival
controller: a7_degraded

uniprot A0A2I3RSK6 205
type: UnificationXref
id: A0A2I3RSK6
db: uniprot

Small ubiquitin-related modifier 3
type: ProteinReference
xref: uniprot Q9Z172 404
organism: Mus musculus

Akt s10 sa9 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.07
comment: MODIFICATION_RESIDUE_NAME=

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Homo sapiens

uniprot H2QXF6 246
type: UnificationXref
id: H2QXF6
db: uniprot

Paired amphipathic helix protein Sin3a
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot Q60520 167
organism: Mus musculus

Cellular tumor antigen p53
type: DnaReference
xref: PTHR11447:SF6
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__p53-RIGHT__p53-_re65
control type: ACTIVATION
controller: CBP

TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re69
type: TemplateReaction
product: PTEN
xref: TRANSCRIPTION
participant: PTEN
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Histone acetyltransferase p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot B2RWS6 26
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6R8N3 281
xref: PTHR24356:SF190
organism: Macaca mulatta

Small ubiquitin-related modifier 3
type: ProteinReference
xref: uniprot Q5ZHQ1 396
organism: Gallus gallus

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: DnaReference
xref: PTHR10411:SF3
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6VXG1 351
xref: PTHR10048:SF107
organism: Xenopus tropicalis

UNKNOWN_TRANSITION_LEFT__Cell_Cycle_Arrest-RIGHT__Tumor_suppression-_re7
type: Interaction
xref: UNKNOWN TRANSITION
participant: Tumor suppression
participant: Cell Cycle Arrest

uniprot G7MHX1 265
type: UnificationXref
id: G7MHX1
db: uniprot

ncbitaxon 9544 10
type: UnificationXref
id: 9544
db: ncbitaxon

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q803G3 335
xref: PTHR45619:SF44
organism: Danio rerio

KAI
type: DnaRegion
entity reference: Kangai 1
comment: SPECIES_TYPE=GENE

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 105

Tumor protein 63
type: DnaReference
xref: PTHR11447:SF8
organism: Mus musculus

a7_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

ATM/ATR
type: Protein
entity reference: ATM/ATR
feature: ACTIVE 11
feature: ATM ATR s42 sa12 rs1
comment: SPECIES_TYPE=PROTEIN

Metastasis associated 1 family member 2
type: ProteinReference
xref: uniprot A0A2I3S626 86
xref: PTHR10865:SF4
organism: Pan troglodytes

Protein PML
type: ProteinReference
xref: uniprot Q60953 118
organism: Mus musculus

Cdc2 s27 sa165 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cdc2
stoichiometric coefficient: 1.0

Histone deacetylase
type: ProteinReference
xref: uniprot A0A2R8QIW0 33
xref: PTHR10625:SF188
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR11139:SF69
xref: uniprot F7HT00 72
organism: Macaca mulatta

Apoptotic protease-activating factor 1
type: DnaReference
xref: PTHR22845:SF5
organism: Homo sapiens

uniprot Q8R080 49
type: UnificationXref
id: Q8R080
db: uniprot

CBP
type: Protein
entity reference: CBP
comment: SPECIES_TYPE=PROTEIN

Complex (HDAC1/MTA)
type: Complex
component stoichiometry: HDAC1 s12 sa155 STOICHIOMETRY ID COMPLEX
component stoichiometry: MTA2 s13 sa156 STOICHIOMETRY ID COMPLEX
component: HDAC1
component: MTA2
feature: COMPLEX BINDING FEATURE s70 csa1 430
feature: COMPLEX BINDING FEATURE s70 csa1 428
feature: ACTIVE 11

uniprot P29590 117
type: UnificationXref
id: P29590
db: uniprot

HDAC1 s12 sa155 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HDAC1
stoichiometric coefficient: 1.0

P21 s22 sa166 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: P21
stoichiometric coefficient: 1.0

PTHR11447:SF8
type: RelationshipXref
id: PTHR11447:SF8
db: PANTHER Family
relationship type: By Homology

PTHR11447:SF6
type: RelationshipXref
id: PTHR11447:SF6
db: PANTHER Family
relationship type: By Homology

uniprot O42354 228
type: UnificationXref
id: O42354
db: uniprot

eco ECO:0000304 51
type: UnificationXref
id: ECO:0000304
db: eco

PDK1/2
type: Protein
entity reference: PDK1/2
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__P300-RIGHT__P300-_re118
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

lys p53 s16 sa1 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys p53 s16 sa1 rs1 lys
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=lys
comment: MODIFICATION_RESIDUE_ANGLE=0.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Inhibition of Angiogenesis and Metastasis
controller: PAI

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot A0A167VDT2 130
organism: Gallus gallus

Serpin family B member 5
type: DnaReference
xref: PTHR11461:SF55
organism: Canis lupus familiaris

PTHR10131:SF21
type: RelationshipXref
id: PTHR10131:SF21
db: PANTHER Family
relationship type: By Homology

Mdm2 s138 sa2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.217183888389608
comment: MODIFICATION_RESIDUE_NAME=

FAS
type: DnaRegion
entity reference: APO-1 or CD95
comment: SPECIES_TYPE=GENE

Growth arrest and DNA-damage-inducible, alpha
type: DnaRegionReference
member entity reference: Growth arrest and DNA damage-inducible protein GADD45 beta
member entity reference: Growth arrest and DNA damage inducible beta
member entity reference: Growth arrest and DNA damage-inducible protein GADD45 alpha
member entity reference: Growth arrest and DNA damage inducible gamma
member entity reference: GADD45B isoform 2
member entity reference: Growth arrest and DNA damage-inducible protein GADD45 gamma
member entity reference: GADD45A isoform 1
member entity reference: Cytokine-responsive protein CR6
member entity reference: Uncharacterized protein
member entity reference: GADD45G isoform 1
xref: G01575
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.GADD45
comment: ENTITY_REFERENCE_NOTES=Long Name: Growth arrest and DNA-damage-inducible, alpha Synonym: Synonym not specified Accession: G01575
display name: GADD45

PDK1/2
type: Protein
entity reference: PDK1/2
comment: SPECIES_TYPE=PROTEIN

Akt
type: Protein
entity reference: Akt
feature: ACTIVE 11
feature: Akt s11 sa10 rs1
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9258 40
type: UnificationXref
id: 9258
db: ncbitaxon

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 308

Cyclin G
type: DnaRegion
entity reference: Cyclin G
comment: SPECIES_TYPE=GENE

Histone deacetylase
type: ProteinReference
xref: PTHR10625:SF203
xref: uniprot F7FJQ1 39
organism: Ornithorhynchus anatinus

Apaf
type: RnaRegion
comment: SPECIES_TYPE=RNA

HETERODIMER_ASSOCIATION_LEFT__MTA2-_HDAC1-RIGHT__Complex__HDAC1_MTA_-_re16
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 507
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 508
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 506
left: HDAC1
left: MTA2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (HDAC1/MTA)

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q1X3 232
xref: PTHR24056:SF254
organism: Macaca mulatta

Cyclin-G1
type: DnaReference
xref: PTHR10177:SF59
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re13
controller: P300

uniprot B5DFH7 153
type: UnificationXref
id: B5DFH7
db: uniprot

Histone acetyltransferase HAC1
type: ProteinReference
xref: PTHR13808:SF1
xref: uniprot Q9C5X9 184
organism: Arabidopsis thaliana

TNF receptor superfamily member 10d
type: DnaReference
xref: PTHR46330:SF4
organism: Pan troglodytes

PTHR10177:SF344
type: RelationshipXref
id: PTHR10177:SF344
db: PANTHER Family
relationship type: By Homology

PTHR10177:SF347
type: RelationshipXref
id: PTHR10177:SF347
db: PANTHER Family
relationship type: By Homology

E2F-1
type: Protein
entity reference: E2F-1
feature: ACTIVE 11
comment: SPECIES_TYPE=PROTEIN

MTA2
type: ProteinReference
xref: P04615
standard name: Metastasis-associated 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Metastasis-associated 2 Synonym: MTA1L1,MTA2,Metastasis-associated protein 1-like,PID Accession: P04615
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.MTA2
member entity reference: Metastasis associated 1 family member 2
member entity reference: Metastasis-associated 1 family member 2
member entity reference: Metastasis-associated protein MTA2
member entity reference: Metastasis-associated 1 family, member 2
member entity reference: Metastasis associated 1-like, isoform D
member entity reference: Uncharacterized protein

uniprot F7BI12 360
type: UnificationXref
id: F7BI12
db: uniprot

PML
type: ProteinReference
xref: P04618
standard name: Promyelocytic leukemia protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.PML
comment: ENTITY_REFERENCE_NOTES=Long Name: Promyelocytic leukemia protein Synonym: Synonym not specified Accession: P04618
member entity reference: Protein PML
member entity reference: Protein PML isoform 1
member entity reference: PML isoform 6

ncbitaxon 13616 38
type: UnificationXref
id: 13616
db: ncbitaxon

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 75

uniprot Q28H04 392
type: UnificationXref
id: Q28H04
db: uniprot

uniprot F6XP81 283
type: UnificationXref
id: F6XP81
db: uniprot

Thrombospondin-1
type: DnaReference
xref: PTHR10199:SF78
organism: Mus musculus

NAD-dependent protein deacetylase sirtuin-1
type: ProteinReference
xref: uniprot Q96EB6 345
xref: PTHR11085:SF15
organism: Homo sapiens

Uncharacterized protein
type: DnaReference
xref: PTHR10177:SF59
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot D3ZC69 120
organism: Rattus norvegicus

B99
type: Protein
entity reference: B99
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa172 445
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re69
control type: ACTIVATION
controller: p53

STATE_TRANSITION_LEFT__CBP-RIGHT__CBP-_re124
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re124 454
participant stoichiometry: PARTICIPANT STOICHIOMETRY re124 455
left: CBP
interaction type: STATE_TRANSITION
right: CBP

Small ubiquitin-related modifier 3
type: ProteinReference
xref: uniprot Q6DI05 400
organism: Danio rerio

Werner syndrome RecQ like helicase
type: ProteinReference
xref: uniprot A0A2I3TSQ1 111
organism: Pan troglodytes

IGF-BP3
type: DnaRegion
entity reference: Insulin-like growth factor-binding protein 3
comment: SPECIES_TYPE=GENE

PTHR24056:SF254
type: RelationshipXref
id: PTHR24056:SF254
db: PANTHER Family
relationship type: By Homology

Cyclin-dependent kinase 2
type: ProteinReference
xref: uniprot Q63699 377
xref: PTHR24056:SF254
organism: Rattus norvegicus

DNA damage-binding protein 2
type: DnaRegionReference
member entity reference: DDB2 isoform 1
member entity reference: DNA damage-binding protein 2
member entity reference: Damage-specific DNA-binding protein 2
member entity reference: Uncharacterized protein
xref: G04705
comment: ENTITY_REFERENCE_NOTES=Long Name: DNA damage-binding protein 2 Synonym: DDB2 Accession: G04705
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.p48
display name: p48

Serine/threonine-protein kinase ATR
type: ProteinReference
xref: PTHR11139:SF69
xref: uniprot Q9JKK8 83
organism: Mus musculus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__B99-RIGHT__B99-_re79
control type: ACTIVATION
controller: p53

Complex (Sin3/HDAC1)
type: Complex
component stoichiometry: HDAC1 s3 sa158 STOICHIOMETRY ID COMPLEX
component stoichiometry: Sin3 s2 sa157 STOICHIOMETRY ID COMPLEX
component: HDAC1
component: Sin3
feature: COMPLEX BINDING FEATURE s68 csa2 448
feature: ACTIVE 11
feature: COMPLEX BINDING FEATURE s68 csa2 446

uniprot H2R491 166
type: UnificationXref
id: H2R491
db: uniprot

uniprot F7E3A7 174
type: UnificationXref
id: F7E3A7
db: uniprot

Growth arrest and DNA damage-inducible protein GADD45 gamma
type: ProteinReference
xref: uniprot Q9WTQ7 259
xref: PTHR10411:SF4
organism: Rattus norvegicus

uniprot H2R7P8 362
type: UnificationXref
id: H2R7P8
db: uniprot

S T Mdm2 s138 sa2 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s138 sa2 rs3 S T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6758332776215386

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7HSM1 319
xref: PTHR45619:SF44
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re63
controller: ATM/ATR

STATE_TRANSITION_LEFT__PiP2-RIGHT__PiP3-_re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 500
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 499
left: PiP2
interaction type: STATE_TRANSITION
right: PiP3

Cyclin B1
type: ProteinReference
xref: PTHR10177:SF193
xref: uniprot Q7ZU21 63
organism: Danio rerio

Tumor protein 63
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot O88898 142
organism: Mus musculus

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 25

Cellular tumor antigen p53
type: DnaReference
xref: PTHR11447:SF6
organism: Rattus norvegicus

TRANSCRIPTION_LEFT__R2-RIGHT__R2-_re105
type: TemplateReaction
product: R2
xref: TRANSCRIPTION
participant: R2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Serine/threonine-protein kinase PKH1
type: ProteinReference
xref: uniprot Q03407 100
xref: PTHR24356:SF368
organism: Saccharomyces cerevisiae

uniprot P23696 321
type: UnificationXref
id: P23696
db: uniprot

Phorbol-12-myristate-13-acetate-induced protein 1
type: DnaReference
organism: Mus musculus

uniprot F1Q2Y3 96
type: UnificationXref
id: F1Q2Y3
db: uniprot

CREB binding protein
type: ProteinReference
xref: uniprot K7DBC8 177
xref: PTHR13808:SF34
organism: Pan troglodytes

P300
type: Protein
entity reference: P300
comment: SPECIES_TYPE=PROTEIN

Serpin family E member 1
type: DnaReference
xref: PTHR11461:SF49
organism: Canis lupus familiaris

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__SIRT_1-RIGHT__SIRT_1-_re125
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

Insulin-like growth factor-binding protein 3
type: DnaReference
organism: Bos taurus

uniprot F7B6Y3 211
type: UnificationXref
id: F7B6Y3
db: uniprot

uniprot O08586 196
type: UnificationXref
id: O08586
db: uniprot

uniprot G5EE01 195
type: UnificationXref
id: G5EE01
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Rattus norvegicus

E3 ubiquitin-protein ligase
type: DnaReference
xref: PTHR45877:SF1
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY re115 476
type: Stoichiometry
physical entity: HMG1
stoichiometric coefficient: 1.0

Histone acetyltransferase
type: ProteinReference
xref: PTHR10615:SF73
xref: uniprot A0A3Q1LU60 169
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re115 475
type: Stoichiometry
physical entity: HMG1
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__PIDD-RIGHT__PIDD-_re86
type: TemplateReaction
product: PIDD
xref: TRANSCRIPTION
participant: PIDD
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Protein Mdm4
type: ProteinReference
xref: uniprot E2RDT3 220
organism: Canis lupus familiaris

Reprimo
type: DnaRegion
comment: SPECIES_TYPE=GENE

MODULATION
type: Control
xref: MODULATION
controlled: UNKNOWN_TRANSITION_LEFT__p53-RIGHT__p53-_re113
controller: WRN

APO-1 or CD95
type: DnaRegionReference
member entity reference: Fas cell surface death receptor
member entity reference: Tumor necrosis factor receptor superfamily member 6
member entity reference: FAS protein
xref: G01571
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.FAS
comment: ENTITY_REFERENCE_NOTES=Long Name: APO-1 or CD95 Synonym: APO-1, CD95 Accession: G01571
display name: FAS

Senescence
type: Pathway

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 61

Mdm2 s85 sa62 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.217183888389608
comment: MODIFICATION_RESIDUE_NAME=

Apoptosis-inducing factor 2
type: DnaReference
organism: Mus musculus

Mdm2
type: Protein
entity reference: Mdm2
feature: S T Mdm2 s139 sa61 rs3
feature: Mdm2 s139 sa61 rs1
feature: S T Mdm2 s139 sa61 rs2
comment: SPECIES_TYPE=PROTEIN

S T Mdm2 s138 sa2 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S T
feature location: S T Mdm2 s138 sa2 rs2 S T
comment: MODIFICATION_RESIDUE_NAME=S/T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.618441538509672

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 375

MODULATION
type: Control
xref: MODULATION
controlled: Senescence
controller: p53

uniprot P38110 76
type: UnificationXref
id: P38110
db: uniprot

CHK2 checkpoint homolog (S. pombe), isoform CRA_a
type: ProteinReference
xref: uniprot Q9R019 209
xref: PTHR44167:SF9
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: PERP

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re61
controller: Mdm2

BCL2-associated X protein
type: DnaReference
xref: PTHR11256:SF42
organism: Xenopus tropicalis

Checkpoint kinase 2
type: ProteinReference
xref: uniprot B0V1J5 206
xref: PTHR44167:SF9
organism: Danio rerio

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 306

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Rattus norvegicus

Small ubiquitin-related modifier 2
type: ProteinReference
xref: uniprot P61959 389
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Mdm2-RIGHT__a101_degraded-_re26
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 489
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 488
left: Mdm2
interaction type: STATE_TRANSITION
right: a101_degraded

Small ubiquitin-related modifier 2
type: ProteinReference
xref: uniprot P61956 387
organism: Homo sapiens

Small ubiquitin-related modifier 2
type: ProteinReference
xref: uniprot P61957 388
organism: Mus musculus

G2/mitotic-specific cyclin-B1
type: ProteinReference
xref: PTHR10177:SF193
xref: uniprot P30277 59
organism: Rattus norvegicus

G2 and S phase-expressed protein 1
type: DnaReference
xref: PTHR21584:SF10
organism: Homo sapiens

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__BAX-RIGHT__BAX-_re91
control type: ACTIVATION
controller: p53

PTEN
type: Protein
entity reference: PTEN
comment: SPECIES_TYPE=PROTEIN

uniprot Q9R019 209
type: UnificationXref
id: Q9R019
db: uniprot

uniprot H2QR05 54
type: UnificationXref
id: H2QR05
db: uniprot

PTHR19282:SF44
type: RelationshipXref
id: PTHR19282:SF44
db: PANTHER Family
relationship type: By Homology

MCG118205, isoform CRA_c
type: ProteinReference
xref: uniprot G5E8H5 194
organism: Mus musculus

KILLER/death receptor (DR)5
type: DnaRegionReference
member entity reference: TNF receptor superfamily member 10b
member entity reference: TNF receptor superfamily member 10d
member entity reference: TNF receptor superfamily member 10a
member entity reference: Tumor necrosis factor receptor superfamily member 10A
member entity reference: Tumor necrosis factor receptor superfamily member 10B
xref: G01568
comment: ENTITY_REFERENCE_NOTES=Long Name: KILLER/death receptor (DR)5 Synonym: Synonym not specified Accession: G01568
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.KILLER/DR5
display name: KILLER/DR5

E3 ubiquitin-protein ligase SIAH1
type: DnaReference
xref: PTHR45877:SF1
organism: Rattus norvegicus

Cyclin-dependent kinase inhibitor 2A
type: DnaRegionReference
member entity reference: Cyclin-dependent kinase inhibitor 2A
member entity reference: Cyclin-dependent kinase 4 inhibitor D
member entity reference: Cyclin-dependent kinase 4 inhibitor B
member entity reference: CDKN2D isoform 1
xref: G01574
comment: ENTITY_REFERENCE_NOTES=Long Name: ARF Synonym: Cyclin-dependent kinase inhibitor 2A,p14ARF(humans),p19ARF (mouse) Accession: G01574
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.GENE.GENE.ARF
display name: ARF

Serine/threonine-protein kinase ATR
type: ProteinReference
xref: uniprot Q9VXG8 84
organism: Drosophila melanogaster

TRANSLATION_LEFT__Reprimo-RIGHT__Reprimo-_re84
type: TemplateReaction
product: Reprimo
xref: TRANSLATION
participant: Reprimo
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_re2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 526
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 527
left: Akt
interaction type: STATE_TRANSITION
right: Akt

BAL1
type: RnaRegion
comment: SPECIES_TYPE=RNA

Aging
type: Pathway

CREB-binding protein
type: ProteinReference
xref: uniprot P45481 180
xref: PTHR13808:SF34
organism: Mus musculus

uniprot C8VB89 65
type: UnificationXref
id: C8VB89
db: uniprot

uniprot A0A2I3TV67 301
type: UnificationXref
id: A0A2I3TV67
db: uniprot

ncbitaxon 185431 375
type: UnificationXref
id: 185431
db: ncbitaxon

uniprot F7BFR8 164
type: UnificationXref
id: F7BFR8
db: uniprot

PTHR13808:SF30
type: RelationshipXref
id: PTHR13808:SF30
db: PANTHER Family
relationship type: By Homology

AIFM2 isoform 1
type: DnaReference
organism: Pan troglodytes

PTHR13808:SF34
type: RelationshipXref
id: PTHR13808:SF34
db: PANTHER Family
relationship type: By Homology

Histone acetyltransferase p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot Q09472 30
organism: Homo sapiens

uniprot F7HSM1 319
type: UnificationXref
id: F7HSM1
db: uniprot

Cyclin-dependent kinase inhibitor 1
type: DnaReference
organism: Homo sapiens

Tumor protein 63 (p63)
type: DnaReference
xref: PTHR11447:SF8
organism: Canis lupus familiaris

PI3-K
type: Protein
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION
type: InteractionVocabulary

eco ECO:0000316 7
type: UnificationXref
id: ECO:0000316
db: eco

High mobility group protein B1
type: ProteinReference
xref: uniprot P10103 125
organism: Bos taurus

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot F1NT98 192
xref: PTHR12305:SF81
organism: Gallus gallus

Adhesion G protein-coupled receptor B1
type: DnaReference
xref: PTHR12011:SF39
organism: Mus musculus

PTHR13808:SF28
type: RelationshipXref
id: PTHR13808:SF28
db: PANTHER Family
relationship type: By Homology

PTHR13808:SF29
type: RelationshipXref
id: PTHR13808:SF29
db: PANTHER Family
relationship type: By Homology

Cellular tumor antigen p53
type: DnaReference
xref: PTHR11447:SF6
organism: Danio rerio

Serine/threonine-protein kinase tel1
type: ProteinReference
xref: uniprot O74630 74
organism: Schizosaccharomyces pombe

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__HMG1-RIGHT__HMG1-_re115
controller: Spindle damage rNTP depletion Nitric oxide and inflammation Hypoxia

uniprot A0A0D1E0Y7 31
type: UnificationXref
id: A0A0D1E0Y7
db: uniprot

MTA2 s13 sa156 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MTA2
stoichiometric coefficient: 1.0

Inhibition of Angiogenesis and Metastasis
type: Pathway

ARF
type: DnaRegion
entity reference: Cyclin-dependent kinase inhibitor 2A
comment: SPECIES_TYPE=GENE

uniprot F1NT98 192
type: UnificationXref
id: F1NT98
db: uniprot

uniprot P63158 126
type: UnificationXref
id: P63158
db: uniprot

uniprot Q62388 82
type: UnificationXref
id: Q62388
db: uniprot

P110alpha
type: ProteinReference
xref: P04633
standard name: Phosphatidylinositol 3-kinase, catalytic subunit, alpha
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphatidylinositol 3-kinase, catalytic subunit, alpha Synonym: P110-alpha,PIK3CA Accession: P04633
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.P110_alpha_
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

PiP2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F1PN31 302
type: UnificationXref
id: F1PN31
db: uniprot

Phorbol-12-myristate-13-acetate-induced protein 1
type: DnaReference
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 492
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 493
left: PDK1/2
interaction type: STATE_TRANSITION
right: PDK1/2

PTHR13808:SF43
type: RelationshipXref
id: PTHR13808:SF43
db: PANTHER Family
relationship type: By Homology

Cyclin-dependent kinase inhibitor 1
type: DnaReference
xref: PTHR46778:SF1
organism: Mus musculus

uniprot Q8RUE8 104
type: UnificationXref
id: Q8RUE8
db: uniprot

Cyclin-dependent kinase inhibitor 2A
type: DnaReference
xref: PTHR24201:SF4
organism: Homo sapiens

Cyclin-dependent kinase 4 inhibitor B
type: DnaReference
organism: Homo sapiens

Sin3
type: ProteinReference
xref: P04622
standard name: Histone deacetylase complex subunit Sin3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway.PROTEIN.GENERIC.Sin3
comment: ENTITY_REFERENCE_NOTES=Long Name: Sin3 Synonym: Synonym not specified Accession: P04622
member entity reference: Paired amphipathic helix protein Sin3a
member entity reference: Uncharacterized protein
member entity reference: SIN3 transcription regulator family member A
member entity reference: SIN3 homolog A, transcription regulator

uniprot F6WCZ7 383
type: UnificationXref
id: F6WCZ7
db: uniprot

Cyclin-dependent kinase 4 inhibitor D
type: DnaReference
organism: Homo sapiens

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P67939 147
xref: PTHR11447:SF6
organism: Bos taurus

14-3-3
type: RnaRegion
comment: SPECIES_TYPE=RNA

Cellular tumor antigen p53
type: DnaReference
xref: PTHR11447:SF6
organism: Macaca mulatta

uniprot P48965 216
type: UnificationXref
id: P48965
db: uniprot

E2F 1 s17 sa160 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: E2F-1
stoichiometric coefficient: 1.0

uniprot P30307 214
type: UnificationXref
id: P30307
db: uniprot

Adhesion G protein-coupled receptor B3
type: DnaReference
organism: Mus musculus

uniprot Q9W0V1 106
type: UnificationXref
id: Q9W0V1
db: uniprot