TSC2 s7 a11 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot H2QNY5 101
organism: Pan troglodytes

Protein kinase AMP-activated non-catalytic subunit gamma 1
type: ProteinReference
xref: uniprot A0A2I3TVR3 49
organism: Pan troglodytes

HETERODIMER_ASSOCIATION_LEFT__TSC1-_TSC2-RIGHT__Complex__TSC2_TSC1_-_re5
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 248
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 247
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 249
left: TSC2
left: TSC1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TSC2/TSC1)

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot W4ZAK5 192
xref: PTHR45619:SF12
organism: Strongylocentrotus purpuratus

uniprot B7QGY5 156
type: UnificationXref
id: B7QGY5
db: uniprot

STATE_TRANSITION_LEFT__Complex__Rheb_GTP_-RIGHT__Pi-_Complex__Rheb_GDP_-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 244
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 245
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 246
left: Complex (Rheb/GTP)
interaction type: STATE_TRANSITION
right: Complex (Rheb/GDP)
right: Pi

uniprot Q2PUH1 81
type: UnificationXref
id: Q2PUH1
db: uniprot

uniprot G2HGR1 65
type: UnificationXref
id: G2HGR1
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F1PL57 95
organism: Canis lupus familiaris

uniprot O88898 103
type: UnificationXref
id: O88898
db: uniprot

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

ncbitaxon 6239 137
type: UnificationXref
id: 6239
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re24 277
type: Stoichiometry
physical entity: TSC1
stoichiometric coefficient: 1.0

ncbitaxon 9606 29
type: UnificationXref
id: 9606
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re24 278
type: Stoichiometry
physical entity: TSC2
stoichiometric coefficient: 1.0

Tumor protein 63
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot Q9H3D4 111
organism: Homo sapiens

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9031 14
type: UnificationXref
id: 9031
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re24 276
type: Stoichiometry
physical entity: Complex (TSC2/TSC1)
stoichiometric coefficient: 1.0

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

uniprot F0ZDJ1 160
type: UnificationXref
id: F0ZDJ1
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6RCU6 126
organism: Macaca mulatta

uniprot E2RH75 52
type: UnificationXref
id: E2RH75
db: uniprot

AMPK s38 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AMPK
stoichiometric coefficient: 1.0

5'-AMP-activated protein kinase subunit beta-1
type: ProteinReference
xref: uniprot F7GTI4 63
organism: Macaca mulatta

PTHR43895:SF25
type: RelationshipXref
id: PTHR43895:SF25
db: PANTHER Family
relationship type: By Homology

Tuberin
type: DnaReference
xref: PTHR10063:SF0
organism: Rattus norvegicus

5'-AMP-activated protein kinase subunit gamma-1
type: ProteinReference
xref: uniprot O54950 70
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 33

uniprot F7DUR2 96
type: UnificationXref
id: F7DUR2
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q7QK56 139
xref: PTHR24356:SF333
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY re16 256
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot B0S576 90
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re16 257
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

uniprot H2QET9 211
type: UnificationXref
id: H2QET9
db: uniprot

uniprot Q803G3 187
type: UnificationXref
id: Q803G3
db: uniprot

uniprot Q7QK56 139
type: UnificationXref
id: Q7QK56
db: uniprot

uniprot Q13131 78
type: UnificationXref
id: Q13131
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: DISSOCIATION_LEFT__Complex__AMPK_ATP_-RIGHT__AMPK-_ATP-_re28
control type: ACTIVATION
controller: Low glucose

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot A0A2I3T9Y4 114
organism: Pan troglodytes

uniprot P56424 107
type: UnificationXref
id: P56424
db: uniprot

uniprot H2QC53 100
type: UnificationXref
id: H2QC53
db: uniprot

uniprot F1P4J0 13
type: UnificationXref
id: F1P4J0
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 35

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Translation
controller: S6K

uniprot F1MYJ4 120
type: UnificationXref
id: F1MYJ4
db: uniprot

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

p53 pathway by glucose deprivation
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__TSC1-_TSC2-RIGHT__Complex__TSC2_TSC1_-_re5
pathway component: STATE_TRANSITION_LEFT__S6K-RIGHT__S6K-_re9
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Insulin_signaling_pathway-RIGHT__Akt-_re25
pathway component: DISSOCIATION_LEFT__Complex__AMPK_ATP_-RIGHT__AMPK-_ATP-_re28
pathway component: UNKNOWN_TRANSITION_LEFT__alpha4-RIGHT__alpha4-_re14
pathway component: DISSOCIATION_LEFT__Complex__TSC2_TSC1_-RIGHT__TSC1-_TSC2-_re24
pathway component: STATE_TRANSITION_LEFT__4E_BP1-RIGHT__4E_BP1-_re10
pathway component: TRANSCRIPTION_LEFT__TSC2-RIGHT__TSC2-_re32
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re17
pathway component: STATE_TRANSITION_LEFT__mTOR-RIGHT__mTOR-_re8
pathway component: DISSOCIATION_LEFT__Complex__AMP_AMPK_-RIGHT__AMPK-_AMP-_re29
pathway component: STATE_TRANSITION_LEFT__TSC2-RIGHT__TSC2-_re33
pathway component: HETERODIMER_ASSOCIATION_LEFT__AMPK-_AMP-RIGHT__Complex__AMP_AMPK_-_re1
pathway component: STATE_TRANSITION_LEFT__TSC2-RIGHT__TSC2-_re4
pathway component: HETERODIMER_ASSOCIATION_LEFT__AMPK-_ATP-RIGHT__Complex__AMPK_ATP_-_re22
pathway component: STATE_TRANSITION_LEFT__Complex__AMP_AMPK_-RIGHT__AMPK-_re3
pathway component: HETERODIMER_ASSOCIATION_LEFT__PP2A_C-_alpha4-RIGHT__Complex__alpha4_PP2A_C_-_re15
pathway component: STATE_TRANSITION_LEFT__Complex__Rheb_GTP_-RIGHT__Pi-_Complex__Rheb_GDP_-_re7
pathway component: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re16
xref: PANTHER Pathway P04397 1
comment: MODEL_NOTES=Panther Pathway: P04397 No pathway definition

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F1MKA9 94
organism: Bos taurus

uniprot F7HR71 64
type: UnificationXref
id: F7HR71
db: uniprot

Protein kinase AMP-activated non-catalytic subunit beta 1
type: ProteinReference
xref: uniprot F6TML6 58
organism: Monodelphis domestica

GTP-binding protein Rheb
type: ProteinReference
xref: uniprot Q921J2 148
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re28 272
type: Stoichiometry
physical entity: AMPK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 271
type: Stoichiometry
physical entity: Complex (AMPK/ATP)
stoichiometric coefficient: 1.0

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot G3X6J7 99
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re1 263
type: Stoichiometry
physical entity: Complex (AMP/AMPK)
stoichiometric coefficient: 1.0

alpha4 s40 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 261
type: Stoichiometry
physical entity: AMPK
stoichiometric coefficient: 1.0

uniprot P67775 181
type: UnificationXref
id: P67775
db: uniprot

PARTICIPANT STOICHIOMETRY re28 273
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 262
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

ncbitaxon 367110 174
type: UnificationXref
id: 367110
db: ncbitaxon

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P63331 179
xref: PTHR45619:SF42
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P63330 178
xref: PTHR45619:SF42
organism: Mus musculus

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 174

uniprot Q27IP4 79
type: UnificationXref
id: Q27IP4
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P56424 107
xref: PTHR11447:SF6
organism: Macaca mulatta

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot H9ENT4 27
xref: PTHR24351:SF48
organism: Macaca mulatta

DISSOCIATION_LEFT__Complex__AMPK_ATP_-RIGHT__AMPK-_ATP-_re28
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 272
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 273
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 271
left: Complex (AMPK/ATP)
interaction type: DISSOCIATION
right: ATP
right: AMPK

GDP s14 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot Q9EP53 206
type: UnificationXref
id: Q9EP53
db: uniprot

uniprot E2R145 51
type: UnificationXref
id: E2R145
db: uniprot

uniprot Q61037 200
type: UnificationXref
id: Q61037
db: uniprot

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot Q8BSK8 32
xref: PTHR24351:SF48
organism: Mus musculus

uniprot Q8BSK8 32
type: UnificationXref
id: Q8BSK8
db: uniprot

Tuberin
type: DnaReference
xref: PTHR10063:SF0
organism: Homo sapiens

Complex (AMP/AMPK)
type: Complex
component stoichiometry: AMP s3 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: AMPK s8 sa2 STOICHIOMETRY ID COMPLEX
component: AMPK
component: AMP
feature: COMPLEX BINDING FEATURE s4 a8 236
feature: COMPLEX BINDING FEATURE s4 a8 234

Tuberin
type: DnaReference
xref: PTHR10063:SF0
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__S6K-RIGHT__S6K-_re9
controller: mTOR

DISSOCIATION_LEFT__Complex__AMP_AMPK_-RIGHT__AMPK-_AMP-_re29
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 269
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 270
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 268
left: Complex (AMP/AMPK)
interaction type: DISSOCIATION
right: AMP
right: AMPK

uniprot F6U7A6 163
type: UnificationXref
id: F6U7A6
db: uniprot

TRANSCRIPTION_LEFT__TSC2-RIGHT__TSC2-_re32
type: TemplateReaction
product: TSC2
xref: TRANSCRIPTION
participant: TSC2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

5'-AMP-activated protein kinase subunit beta-1
type: ProteinReference
xref: uniprot Q9Y478 88
organism: Homo sapiens

uniprot Q9Y478 88
type: UnificationXref
id: Q9Y478
db: uniprot

uniprot F7HSM1 168
type: UnificationXref
id: F7HSM1
db: uniprot

uniprot F6QP11 124
type: UnificationXref
id: F6QP11
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 25

uniprot Q8UUX0 142
type: UnificationXref
id: Q8UUX0
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 19

AMPK
type: Protein
entity reference: AMPK
feature: AMPK s5 a9 rs1
feature: ACTIVE 38
comment: SPECIES_TYPE=PROTEIN

Rheb s10 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rheb
stoichiometric coefficient: 1.0

PTHR10933:SF11
type: RelationshipXref
id: PTHR10933:SF11
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q6P365 185
xref: PTHR45619:SF42
organism: Xenopus tropicalis

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot F6UK84 18
organism: Xenopus tropicalis

PTHR10933:SF12
type: RelationshipXref
id: PTHR10933:SF12
db: PANTHER Family
relationship type: By Homology

uniprot P02340 104
type: UnificationXref
id: P02340
db: uniprot

PARTICIPANT STOICHIOMETRY re29 270
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

PP2A C s41 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A-C
stoichiometric coefficient: 1.0

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

uniprot E7EXT6 119
type: UnificationXref
id: E7EXT6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1PIY1 56
organism: Canis lupus familiaris

uniprot E2RMD8 12
type: UnificationXref
id: E2RMD8
db: uniprot

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

Ribosomal protein S6 kinase beta-2
type: ProteinReference
xref: uniprot Q9Z1M4 37
xref: PTHR24351:SF171
organism: Mus musculus

uniprot G5EGK8 169
type: UnificationXref
id: G5EGK8
db: uniprot

uniprot A0A2I3T9Y4 114
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

uniprot A8X0Q9 152
type: UnificationXref
id: A8X0Q9
db: uniprot

uniprot Q921J2 148
type: UnificationXref
id: Q921J2
db: uniprot

uniprot P23443 28
type: UnificationXref
id: P23443
db: uniprot

Rheb
type: ProteinReference
xref: P04642
standard name: Ras homolog enriched in brain 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.Rheb
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ras homolog, mTORC1-binding
member entity reference: GTP-binding protein Rheb
member entity reference: GTP-binding protein Rheb homolog

AMPK
type: Protein
entity reference: AMPK
feature: AMPK s2 a5 rs1
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: UNKNOWN_TRANSITION_LEFT__alpha4-RIGHT__alpha4-_re14
controller: mTOR

Akt
type: Protein
entity reference: Akt
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Z1M4 37
type: UnificationXref
id: Q9Z1M4
db: uniprot

S6K
type: ProteinReference
xref: P04636
standard name: ribosomal protein S6 kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.S6K
comment: ENTITY_REFERENCE_NOTES=Long Name: S6K Synonym: Ribosomal protein S6 kinase Accession: P04636
member entity reference: Ribosomal protein S6 kinase beta-2
member entity reference: Ribosomal protein S6 kinase
member entity reference: Ribosomal protein S6 kinase beta-1
member entity reference: Non-specific serine/threonine protein kinase

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot Q29537 110
xref: PTHR11447:SF6
organism: Canis lupus familiaris

Tuberin
type: ProteinReference
xref: PTHR10063:SF0
xref: uniprot Q61037 200
organism: Mus musculus

uniprot P04637 105
type: UnificationXref
id: P04637
db: uniprot

uniprot O54950 70
type: UnificationXref
id: O54950
db: uniprot

uniprot F7CP86 165
type: UnificationXref
id: F7CP86
db: uniprot

uniprot F6TPX7 16
type: UnificationXref
id: F6TPX7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12669:SF14
xref: uniprot F7C5U8 40
organism: Macaca mulatta

Complex (Rheb/GTP)
type: Complex
component stoichiometry: GTP s12 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rheb s10 sa5 STOICHIOMETRY ID COMPLEX
component: GTP
component: Rheb
feature: COMPLEX BINDING FEATURE s15 a22 220
feature: ACTIVE 38
feature: COMPLEX BINDING FEATURE s15 a22 218

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A2R8QBK5 2
organism: Danio rerio

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa8 233
comment: SPECIES_TYPE=SIMPLE_MOLECULE

GTP-binding protein Rheb
type: ProteinReference
xref: PTHR24070:SF264
xref: uniprot Q15382 147
organism: Homo sapiens

PTHR15154:SF2
type: RelationshipXref
id: PTHR15154:SF2
db: PANTHER Family
relationship type: By Homology

uniprot F1PZE3 39
type: UnificationXref
id: F1PZE3
db: uniprot

uniprot Q0P594 182
type: UnificationXref
id: Q0P594
db: uniprot

ATP s39 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot F1PBG0 55
type: UnificationXref
id: F1PBG0
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot E7EXT6 119
organism: Danio rerio

uniprot P49815 198
type: UnificationXref
id: P49815
db: uniprot

uniprot Q60876 44
type: UnificationXref
id: Q60876
db: uniprot

uniprot A0A1D5QWE9 47
type: UnificationXref
id: A0A1D5QWE9
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot H2QC53 100
xref: PTHR11447:SF6
organism: Pan troglodytes

TSC complex subunit 2
type: DnaReference
xref: PTHR10063:SF0
organism: Canis lupus familiaris

5'-AMP-activated protein kinase subunit beta-2
type: ProteinReference
xref: uniprot O43741 69
organism: Homo sapiens

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot H2QRH7 170
xref: PTHR45619:SF42
organism: Pan troglodytes

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot F7E5M4 166
organism: Ornithorhynchus anatinus

Protein kinase AMP-activated non-catalytic subunit beta 2
type: ProteinReference
xref: uniprot E1B986 50
organism: Bos taurus

Hamartin
type: ProteinReference
xref: PTHR15154:SF2
xref: uniprot Q9EP53 206
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 124
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re29 268
type: Stoichiometry
physical entity: Complex (AMP/AMPK)
stoichiometric coefficient: 1.0

uniprot P48580 173
type: UnificationXref
id: P48580
db: uniprot

PARTICIPANT STOICHIOMETRY re29 269
type: Stoichiometry
physical entity: AMPK
stoichiometric coefficient: 1.0

alpha4
type: ProteinReference
xref: P04646
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC._alpha_4
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Immunoglobulin-binding protein 1

uniprot F1MQV7 54
type: UnificationXref
id: F1MQV7
db: uniprot

5'-AMP-activated protein kinase catalytic subunit alpha-2
type: ProteinReference
xref: uniprot Q8BRK8 85
organism: Mus musculus

uniprot F7D386 62
type: UnificationXref
id: F7D386
db: uniprot

uniprot A0A2R8QBK5 2
type: UnificationXref
id: A0A2R8QBK5
db: uniprot

TSC1 s43 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TSC1
stoichiometric coefficient: 1.0

LKB1
type: Protein
entity reference: LKB1
feature: ACTIVE 38
comment: SPECIES_TYPE=PROTEIN

uniprot H2PZ45 66
type: UnificationXref
id: H2PZ45
db: uniprot

uniprot Q13541 43
type: UnificationXref
id: Q13541
db: uniprot

ncbitaxon 7739 159
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot E1B986 50
type: UnificationXref
id: E1B986
db: uniprot

uniprot H2R1U8 197
type: UnificationXref
id: H2R1U8
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P79734 109
xref: PTHR11447:SF6
organism: Danio rerio

Akt
type: ProteinReference
xref: P04641
standard name: protein kinase B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.Akt
comment: ENTITY_REFERENCE_NOTES=Long Name: Akt Synonym: ONCOGENE AKT1,ONCOGENE AKT2,PKB,PKB-ALPHA,PKB-BETA,PROTEIN KINASE B-ALPHA,PROTEIN KINASE B-BETA,RAC SERINE/THREONINE PROTEIN KINASE Accession: P04641 Pathway Link: P00033|P00894|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04665|p53 pathway feedback loops 2*P00059|P01486|p53 pathway
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: Serine/threonine-protein kinase akt-1
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC serine/threonine-protein kinase

4E-BP1
type: Protein
entity reference: 4E-BP1
feature: 4E BP1 s21 a29 rs1
comment: SPECIES_TYPE=PROTEIN

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9Y243 144
organism: Homo sapiens

STATE_TRANSITION_LEFT__TSC2-RIGHT__TSC2-_re33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 239
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 238
left: TSC2
interaction type: STATE_TRANSITION
right: TSC2

uniprot Q9XZE5 190
type: UnificationXref
id: Q9XZE5
db: uniprot

Translation
type: Pathway

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot H2PZ45 66
organism: Pan troglodytes

uniprot P67774 180
type: UnificationXref
id: P67774
db: uniprot

S6K s19 a26 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ncbitaxon 7668 193
type: UnificationXref
id: 7668
db: ncbitaxon

TSC2
type: Protein
entity reference: TSC2
feature: TSC2 s7 a11 rs1
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZGN9 210
xref: PTHR43895:SF25
organism: Macaca mulatta

p53
type: Protein
entity reference: p53
feature: S15 p53 s27 a38 rs1
feature: ACTIVE 38
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re7 244
type: Stoichiometry
physical entity: Complex (Rheb/GTP)
stoichiometric coefficient: 1.0

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot E1BLQ5 8
organism: Bos taurus

p53
type: ProteinReference
xref: P04640
standard name: Tumor protein p53
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.p53
comment: ENTITY_REFERENCE_NOTES=Long Name: p53 Synonym: Synonym not specified Accession: P04640 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04668|p53 pathway feedback loops 2*P00059|P01485|p53 pathway
member entity reference: Tumor protein 63
member entity reference: Cellular tumor antigen p53
member entity reference: Tumor protein 63 (p63)
member entity reference: Tumor protein p73

PTHR11139:SF9
type: RelationshipXref
id: PTHR11139:SF9
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re7 246
type: Stoichiometry
physical entity: Complex (Rheb/GDP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 245
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

uniprot P49816 199
type: UnificationXref
id: P49816
db: uniprot

G04706
type: UnificationXref
id: G04706
db: PANTHER Pathway Component

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 133
organism: Homo sapiens

uniprot Q94533 34
type: UnificationXref
id: Q94533
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 132
organism: Mus musculus

Ras homolog, mTORC1-binding
type: ProteinReference
xref: PTHR24070:SF264
xref: uniprot F6TB23 146
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY re17 253
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 252
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot B7QGY5 156
organism: Ixodes scapularis

Bos taurus
type: BioSource
xref: ncbitaxon 9913 9

uniprot Q9UBS0 36
type: UnificationXref
id: Q9UBS0
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P04637 105
xref: PTHR11447:SF6
organism: Homo sapiens

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9WUA6 143
organism: Mus musculus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F1Q6Z7 162
xref: PTHR45619:SF42
organism: Danio rerio

UNKNOWN_TRANSITION
type: InteractionVocabulary

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 23

00696
type: UnificationXref
id: MOD:00696
db: mod

PTHR24351:SF171
type: RelationshipXref
id: PTHR24351:SF171
db: PANTHER Family
relationship type: By Homology

Low glucose
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 17

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot H2Q486 24
organism: Pan troglodytes

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot P23443 28
xref: PTHR24351:SF48
organism: Homo sapiens

AMPK
type: Protein
entity reference: AMPK
feature: AMPK s8 sa2 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa2 237
comment: SPECIES_TYPE=PROTEIN

uniprot F6R8N3 125
type: UnificationXref
id: F6R8N3
db: uniprot

KNOWN_TRANSITION_OMITTED_LEFT__Insulin_signaling_pathway-RIGHT__Akt-_re25
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 274
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 275
left: Insulin signaling pathway
interaction type: KNOWN_TRANSITION_OMITTED
right: Akt

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62715 176
xref: PTHR45619:SF44
organism: Mus musculus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62716 177
xref: PTHR45619:SF44
organism: Rattus norvegicus

uniprot F6YST6 60
type: UnificationXref
id: F6YST6
db: uniprot

Tuberous sclerosis 2
type: DnaRegionReference
member entity reference: Tuberin
member entity reference: TSC complex subunit 2
member entity reference: Uncharacterized protein
xref: G04706
comment: ENTITY_REFERENCE_NOTES=Long Name: TSC2 Synonym: Synonym not specified Accession: G04706
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.GENE.GENE.TSC2
display name: TSC2

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31749 131
xref: PTHR24356:SF171
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot P62714 175
organism: Homo sapiens

uniprot A7T2Q5 150
type: UnificationXref
id: A7T2Q5
db: uniprot

uniprot F6TML6 58
type: UnificationXref
id: F6TML6
db: uniprot

uniprot E9QG65 92
type: UnificationXref
id: E9QG65
db: uniprot

Eukaryotic translation initiation factor 4E-binding protein 1
type: ProteinReference
xref: PTHR12669:SF14
xref: uniprot Q62622 45
organism: Rattus norvegicus

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9544 23
type: UnificationXref
id: 9544
db: ncbitaxon

Hamartin
type: ProteinReference
xref: PTHR15154:SF2
xref: uniprot Q9Z136 207
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot B1WB72 117
organism: Xenopus tropicalis

uniprot P78318 201
type: UnificationXref
id: P78318
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 157

TSC1
type: Protein
entity reference: TSC1
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa4 217
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7H808 167
xref: PTHR45619:SF42
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

ncbitaxon 10228 155
type: UnificationXref
id: 10228
db: ncbitaxon

Complex (AMPK/ATP)
type: Complex
component stoichiometry: ATP s39 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: AMPK s38 sa11 STOICHIOMETRY ID COMPLEX
component: ATP
component: AMPK
feature: COMPLEX BINDING FEATURE s32 a45 224
feature: COMPLEX BINDING FEATURE s32 a45 222

TSC complex subunit 1
type: ProteinReference
xref: PTHR15154:SF2
xref: uniprot A0A2I3RGP6 203
organism: Pan troglodytes

uniprot F6XJN6 59
type: UnificationXref
id: F6XJN6
db: uniprot

uniprot Q8INB9 141
type: UnificationXref
id: Q8INB9
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 11

uniprot D4AA88 91
type: UnificationXref
id: D4AA88
db: uniprot

uniprot P47196 134
type: UnificationXref
id: P47196
db: uniprot

AMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TSC2
type: Protein
entity reference: TSC2
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa3 215
feature: TSC2 s42 sa3 rs1
feature: ACTIVE 38
comment: SPECIES_TYPE=PROTEIN

RAC serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q8INB9 141
organism: Drosophila melanogaster

uniprot Q15382 147
type: UnificationXref
id: Q15382
db: uniprot

uniprot C3XQF4 158
type: UnificationXref
id: C3XQF4
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot E2RMD8 12
organism: Canis lupus familiaris

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot F7DUR2 96
xref: PTHR11447:SF8
organism: Ornithorhynchus anatinus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot E2R7K9 10
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q6GLE6 184
xref: PTHR45619:SF44
organism: Xenopus tropicalis

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 14

uniprot A0A2I3RGP6 203
type: UnificationXref
id: A0A2I3RGP6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re17
controller: AMPK

PRKAB2 isoform 1
type: ProteinReference
xref: uniprot A0A2I3SPU1 48
organism: Pan troglodytes

STATE_TRANSITION_LEFT__mTOR-RIGHT__mTOR-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 242
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 243
left: mTOR
interaction type: STATE_TRANSITION
right: mTOR

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot Q94533 34
organism: Drosophila melanogaster

uniprot F6V748 196
type: UnificationXref
id: F6V748
db: uniprot

uniprot F6R539 57
type: UnificationXref
id: F6R539
db: uniprot

STATE_TRANSITION_LEFT__TSC2-RIGHT__TSC2-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 250
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 251
left: TSC2
interaction type: STATE_TRANSITION
right: TSC2

uniprot F1PL57 95
type: UnificationXref
id: F1PL57
db: uniprot

TSC complex subunit 2
type: DnaReference
xref: PTHR10063:SF0
organism: Bos taurus

uniprot Q567Y8 183
type: UnificationXref
id: Q567Y8
db: uniprot

Eukaryotic translation initiation factor 4E binding protein 1
type: ProteinReference
xref: PTHR12669:SF14
xref: uniprot K7D2T0 41
organism: Pan troglodytes

uniprot F7E5M4 166
type: UnificationXref
id: F7E5M4
db: uniprot

p53
type: Protein
entity reference: p53
feature: S15 p53 s28 a39 rs1
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION
type: RelationshipTypeVocabulary

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot F6X958 164
organism: Canis lupus familiaris

uniprot P79734 109
type: UnificationXref
id: P79734
db: uniprot

uniprot P23696 171
type: UnificationXref
id: P23696
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__mTOR-RIGHT__mTOR-_re8
controller: Complex (Rheb/GTP)

Tuberin
type: ProteinReference
xref: PTHR10063:SF0
xref: uniprot P49815 198
organism: Homo sapiens

Tuberin
type: ProteinReference
xref: PTHR10063:SF0
xref: uniprot P49816 199
organism: Rattus norvegicus

AMP s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

Eukaryotic translation initiation factor 4E-binding protein 1
type: ProteinReference
xref: PTHR12669:SF14
xref: uniprot Q13541 43
organism: Homo sapiens

uniprot K7CDC2 130
type: UnificationXref
id: K7CDC2
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR10063:SF0
organism: Macaca mulatta

5'-AMP-activated protein kinase subunit beta-2
type: ProteinReference
xref: uniprot Q9QZH4 86
organism: Rattus norvegicus

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot D4AA88 91
organism: Rattus norvegicus

Complex (alpha4/PP2A-C)
type: Complex
component stoichiometry: alpha4 s40 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: PP2A C s41 sa10 STOICHIOMETRY ID COMPLEX
component: alpha4
component: PP2A-C
feature: COMPLEX BINDING FEATURE s26 a37 228
feature: COMPLEX BINDING FEATURE s26 a37 226

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q2U4X3 116
xref: PTHR24356:SF171
organism: Gallus gallus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XJN6 59
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__AMP_AMPK_-RIGHT__AMPK-_re3
controller: LKB1

uniprot O15350 102
type: UnificationXref
id: O15350
db: uniprot

Autophagy
type: Pathway

TSC complex subunit 2
type: ProteinReference
xref: uniprot E1BNT2 194
xref: PTHR10063:SF0
organism: Bos taurus

ncbitaxon 44689 191
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot Q8BRK8 85
type: UnificationXref
id: Q8BRK8
db: uniprot

TSC complex subunit 2
type: ProteinReference
xref: PTHR10063:SF0
xref: uniprot F1Q054 195
organism: Canis lupus familiaris

S6K
type: Protein
entity reference: S6K
feature: S6K s19 a26 rs1
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q0P594 182
xref: PTHR45619:SF44
organism: Bos taurus

uniprot Q09137 77
type: UnificationXref
id: Q09137
db: uniprot

uniprot G3X7B5 129
type: UnificationXref
id: G3X7B5
db: uniprot

uniprot P31751 133
type: UnificationXref
id: P31751
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q8UUX0 142
organism: Danio rerio

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 153

AMP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 235
comment: SPECIES_TYPE=SIMPLE_MOLECULE

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa6 221
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR10063:SF0
type: RelationshipXref
id: PTHR10063:SF0
db: PANTHER Family
relationship type: By Homology

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 137

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F6R8N3 125
organism: Macaca mulatta

ATP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa12 225
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9VND8 149
type: UnificationXref
id: Q9VND8
db: uniprot

4E-BP1
type: ProteinReference
xref: P04637
standard name: Eukaryotic translation initiation factor 4E-binding protein 1
comment: ENTITY_REFERENCE_NOTES=Long Name: Eukaryotic translation initiation factor 4E-binding protein 1 Synonym: EIF4EBP1 Accession: P04637
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.4E-BP1
member entity reference: Eukaryotic translation initiation factor 4E-binding protein 1
member entity reference: Eukaryotic translation initiation factor 4E binding protein 1
member entity reference: Uncharacterized protein

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7HR71 64
organism: Macaca mulatta

Serine/threonine kinase 11
type: ProteinReference
xref: PTHR43895:SF25
xref: uniprot H2QET9 211
organism: Pan troglodytes

AMPK s38 sa11 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ncbitaxon 10090 33
type: UnificationXref
id: 10090
db: ncbitaxon

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot F7GA51 98
organism: Macaca mulatta

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47196 134
xref: PTHR24356:SF171
organism: Rattus norvegicus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47197 135
xref: PTHR24356:SF176
organism: Rattus norvegicus

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot Q9JJP2 112
organism: Mus musculus

uniprot O43741 69
type: UnificationXref
id: O43741
db: uniprot

Tumor protein 63
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot Q9JJP6 113
organism: Rattus norvegicus

uniprot B3S653 154
type: UnificationXref
id: B3S653
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot Q803G3 187
organism: Danio rerio

uniprot P58108 74
type: UnificationXref
id: P58108
db: uniprot

TSC2
type: ProteinReference
xref: P04644
standard name: Tuberous sclerosis 2
comment: ENTITY_REFERENCE_NOTES=Long Name: TSC2 Synonym: Synonym not specified Accession: P04644
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.TSC2
member entity reference: Tuberin
member entity reference: Uncharacterized protein
member entity reference: TSC complex subunit 2

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6U7A6 163
xref: PTHR45619:SF42
organism: Monodelphis domestica

UNKNOWN_TRANSITION_LEFT__alpha4-RIGHT__alpha4-_re14
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 265
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 264
left: alpha4
interaction type: UNKNOWN_TRANSITION
right: alpha4

uniprot F7GA51 98
type: UnificationXref
id: F7GA51
db: uniprot

uniprot F7H808 167
type: UnificationXref
id: F7H808
db: uniprot

uniprot H2R5J1 67
type: UnificationXref
id: H2R5J1
db: uniprot

TSC2
type: RnaRegion
comment: SPECIES_TYPE=RNA

uniprot Q9WTK7 213
type: UnificationXref
id: Q9WTK7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4E_BP1-RIGHT__4E_BP1-_re10
controller: mTOR

uniprot F6TB23 146
type: UnificationXref
id: F6TB23
db: uniprot

4E-BP1
type: Protein
entity reference: 4E-BP1
feature: ACTIVE 38
feature: 4E BP1 s20 a28 rs1
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__4E_BP1-RIGHT__4E_BP1-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 266
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 267
left: 4E-BP1
interaction type: STATE_TRANSITION
right: 4E-BP1

uniprot Q7PD38 186
type: UnificationXref
id: Q7PD38
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q567Y8 183
xref: PTHR45619:SF42
organism: Danio rerio

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

ncbitaxon 7227 35
type: UnificationXref
id: 7227
db: ncbitaxon

HETERODIMER_ASSOCIATION_LEFT__PP2A_C-_alpha4-RIGHT__Complex__alpha4_PP2A_C_-_re15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 258
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 260
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 259
left: PP2A-C
left: alpha4
interaction type: HETERODIMER_ASSOCIATION
right: Complex (alpha4/PP2A-C)

5'AMP-activated protein kinase beta-1 non-catalytic subunit
type: ProteinReference
xref: uniprot Q27IP4 79
organism: Gallus gallus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F7GEK1 128
organism: Monodelphis domestica

uniprot F6RCU6 126
type: UnificationXref
id: F6RCU6
db: uniprot

TSC2
type: DnaRegion
entity reference: Tuberous sclerosis 2
comment: SPECIES_TYPE=GENE

Serine/threonine-protein phosphatase 2A catalytic subunit A
type: ProteinReference
xref: uniprot Q9XZE5 190
xref: PTHR45619:SF12
organism: Dictyostelium discoideum

ncbitaxon 8364 19
type: UnificationXref
id: 8364
db: ncbitaxon

Pi
type: SmallMolecule
comment: SPECIES_TYPE=ION

Immunoglobulin-binding protein 1
type: ProteinReference
xref: uniprot P78318 201
xref: PTHR10933:SF12
organism: Homo sapiens

ncbitaxon 9913 9
type: UnificationXref
id: 9913
db: ncbitaxon

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 140

uniprot F6Y6G0 204
type: UnificationXref
id: F6Y6G0
db: uniprot

5'-AMP-activated protein kinase catalytic subunit alpha-1
type: ProteinReference
xref: uniprot Q5EG47 83
organism: Mus musculus

Rheb
type: Protein
entity reference: Rheb
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa7 231
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re14 265
type: Stoichiometry
physical entity: alpha4
stoichiometric coefficient: 1.0

mTOR
type: Protein
entity reference: mTOR
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase 2A catalytic subunit
type: ProteinReference
xref: uniprot G5EGK8 169
organism: Caenorhabditis elegans

PTHR11447:SF8
type: RelationshipXref
id: PTHR11447:SF8
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re14 264
type: Stoichiometry
physical entity: alpha4
stoichiometric coefficient: 1.0

PTHR11447:SF6
type: RelationshipXref
id: PTHR11447:SF6
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase STK11
type: ProteinReference
xref: uniprot D4AE59 208
xref: PTHR43895:SF25
organism: Rattus norvegicus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot H2QDK7 26
organism: Pan troglodytes

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot A0A167VDT2 89
organism: Gallus gallus

Complex (TSC2/TSC1)
type: Complex
component stoichiometry: TSC1 s43 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: TSC2 s42 sa3 STOICHIOMETRY ID COMPLEX
component: TSC1
component: TSC2
feature: COMPLEX BINDING FEATURE s11 a17 214
feature: COMPLEX BINDING FEATURE s11 a17 216

Eukaryotic translation initiation factor 4E-binding protein 1
type: ProteinReference
xref: PTHR12669:SF14
xref: uniprot Q0P5A7 42
organism: Bos taurus

5'-AMP-activated protein kinase subunit gamma-1
type: ProteinReference
xref: uniprot P54619 71
organism: Homo sapiens

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q60823 138
organism: Mus musculus

uniprot H2QNY5 101
type: UnificationXref
id: H2QNY5
db: uniprot

ncbitaxon 6238 153
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot F7CQS0 22
type: UnificationXref
id: F7CQS0
db: uniprot

uniprot F1PIY1 56
type: UnificationXref
id: F1PIY1
db: uniprot

TSC2 s42 sa3 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

mTOR
type: Protein
entity reference: mTOR
feature: ACTIVE 38
comment: SPECIES_TYPE=PROTEIN

uniprot Q9VK45 46
type: UnificationXref
id: Q9VK45
db: uniprot

uniprot P67999 30
type: UnificationXref
id: P67999
db: uniprot

uniprot K7D2T0 41
type: UnificationXref
id: K7D2T0
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 159

TSC1
type: Protein
entity reference: TSC1
comment: SPECIES_TYPE=PROTEIN

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 155

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re16
controller: Complex (alpha4/PP2A-C)

uniprot P62714 175
type: UnificationXref
id: P62714
db: uniprot

uniprot P31750 132
type: UnificationXref
id: P31750
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: p53 pathway
controller: p53

AMPK s8 sa2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q17941 136
type: UnificationXref
id: Q17941
db: uniprot

uniprot Q6P365 185
type: UnificationXref
id: Q6P365
db: uniprot

TSC complex subunit 2
type: ProteinReference
xref: PTHR10063:SF0
xref: uniprot H2R1U8 197
organism: Pan troglodytes

Protein kinase AMP-activated non-catalytic subunit beta 1
type: ProteinReference
xref: uniprot E2RH75 52
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re4 251
type: Stoichiometry
physical entity: TSC2
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot P48463 172
organism: Gallus gallus

ACTIVE 38
type: EntityFeature
comment: Active state

uniprot A0A2I3SPU1 48
type: UnificationXref
id: A0A2I3SPU1
db: uniprot

uniprot F7GEK1 128
type: UnificationXref
id: F7GEK1
db: uniprot

4E BP1 s20 a28 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re4 250
type: Stoichiometry
physical entity: TSC2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 239
type: Stoichiometry
physical entity: TSC2
stoichiometric coefficient: 1.0

5'-AMP-activated protein kinase catalytic subunit alpha-1
type: ProteinReference
xref: uniprot Q13131 78
organism: Homo sapiens

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 21

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot E2RJX4 118
type: UnificationXref
id: E2RJX4
db: uniprot

uniprot D4AE24 4
type: UnificationXref
id: D4AE24
db: uniprot

PARTICIPANT STOICHIOMETRY re33 238
type: Stoichiometry
physical entity: TSC2
stoichiometric coefficient: 1.0

uniprot Q0P5A7 42
type: UnificationXref
id: Q0P5A7
db: uniprot

TSC2 s42 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TSC2
stoichiometric coefficient: 1.0

uniprot Q15831 212
type: UnificationXref
id: Q15831
db: uniprot

PARTICIPANT STOICHIOMETRY re8 243
type: Stoichiometry
physical entity: mTOR
stoichiometric coefficient: 1.0

TSC2
type: Protein
entity reference: TSC2
feature: TSC2 s36 a12 rs1
feature: ACTIVE 38
comment: SPECIES_TYPE=PROTEIN

uniprot F7FN64 97
type: UnificationXref
id: F7FN64
db: uniprot

PARTICIPANT STOICHIOMETRY re8 242
type: Stoichiometry
physical entity: mTOR
stoichiometric coefficient: 1.0

uniprot F6X958 164
type: UnificationXref
id: F6X958
db: uniprot

TSC complex subunit 2
type: DnaReference
xref: PTHR10063:SF0
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MBG5 53
organism: Bos taurus

Serine/threonine kinase 11
type: ProteinReference
xref: uniprot F6PM85 209
organism: Xenopus tropicalis

uniprot Q9WUA6 143
type: UnificationXref
id: Q9WUA6
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F6TPX7 16
xref: PTHR24351:SF48
organism: Ornithorhynchus anatinus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F6QE96 123
organism: Macaca mulatta

uniprot F1Q054 195
type: UnificationXref
id: F1Q054
db: uniprot

Rheb
type: Protein
entity reference: Rheb
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa5 219
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION
type: InteractionVocabulary

Protein kinase AMP-activated non-catalytic subunit gamma 1
type: ProteinReference
xref: uniprot F1PBG0 55
organism: Canis lupus familiaris

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__TSC2-RIGHT__TSC2-_re33
control type: ACTIVATION
controller: TSC2

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot Q6TJY3 31
xref: PTHR24351:SF48
organism: Bos taurus

STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 257
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 256
left: p53
interaction type: STATE_TRANSITION
right: p53

STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 253
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 252
left: p53
interaction type: STATE_TRANSITION
right: p53

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F1PRG4 121
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re3 254
type: Stoichiometry
physical entity: Complex (AMP/AMPK)
stoichiometric coefficient: 1.0

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot D4AE24 4
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re3 255
type: Stoichiometry
physical entity: AMPK
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7D386 62
organism: Macaca mulatta

uniprot P62716 177
type: UnificationXref
id: P62716
db: uniprot

alpha4
type: Protein
entity reference: alpha4
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa9 227
feature: ACTIVE 38
comment: SPECIES_TYPE=PROTEIN

AMPK s2 a5 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ncbitaxon 7955 3
type: UnificationXref
id: 7955
db: ncbitaxon

DISSOCIATION
type: InteractionVocabulary

uniprot P10361 106
type: UnificationXref
id: P10361
db: uniprot

uniprot P63330 178
type: UnificationXref
id: P63330
db: uniprot

Hamartin
type: ProteinReference
xref: PTHR15154:SF2
xref: uniprot Q92574 205
organism: Homo sapiens

uniprot E1BLQ5 8
type: UnificationXref
id: E1BLQ5
db: uniprot

PARTICIPANT STOICHIOMETRY re25 274
type: Stoichiometry
physical entity: Insulin signaling pathway
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 275
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6R539 57
organism: Xenopus tropicalis

ncbitaxon 7165 140
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot D4AE59 208
type: UnificationXref
id: D4AE59
db: uniprot

uniprot P48463 172
type: UnificationXref
id: P48463
db: uniprot

5'-AMP-activated protein kinase subunit gamma-1
type: ProteinReference
xref: uniprot P58108 74
organism: Bos taurus

uniprot B0S576 90
type: UnificationXref
id: B0S576
db: uniprot

ncbitaxon 9598 25
type: UnificationXref
id: 9598
db: ncbitaxon

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot F0ZDJ1 160
organism: Dictyostelium purpureum

ncbitaxon 9615 11
type: UnificationXref
id: 9615
db: ncbitaxon

AMPK
type: ProteinReference
xref: P04639
standard name: AMP-activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.AMPK
comment: ENTITY_REFERENCE_NOTES=Long Name: AMP-activated protein kinase Synonym: Synonym not specified Accession: P04639
member entity reference: Protein kinase AMP-activated non-catalytic subunit beta 1
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: 5'-AMP-activated protein kinase subunit beta-1
member entity reference: 5'-AMP-activated protein kinase subunit gamma-1
member entity reference: Protein kinase AMP-activated non-catalytic subunit beta 2
member entity reference: 5'AMP-activated protein kinase beta-1 non-catalytic subunit
member entity reference: 5'-AMP-activated protein kinase subunit beta-2
member entity reference: 5'-AMP-activated protein kinase catalytic subunit alpha-1
member entity reference: Protein kinase AMP-activated non-catalytic subunit gamma 1
member entity reference: 5'-AMP-activated protein kinase catalytic subunit alpha-2
member entity reference: PRKAB2 isoform 1
member entity reference: 5'-AMP-activated protein kinase subunit gamma-1 isoform 1

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 29

ncbitaxon 45351 151
type: UnificationXref
id: 45351
db: ncbitaxon

Eukaryotic translation initiation factor 4E binding protein 1
type: ProteinReference
xref: PTHR12669:SF14
xref: uniprot F1PZE3 39
organism: Canis lupus familiaris

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot H2R5J1 67
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MQV7 54
organism: Bos taurus

Eukaryotic translation initiation factor 4E-binding protein 1
type: ProteinReference
xref: PTHR12669:SF14
xref: uniprot Q60876 44
organism: Mus musculus

uniprot Q92574 205
type: UnificationXref
id: Q92574
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7HSM1 168
xref: PTHR45619:SF44
organism: Macaca mulatta

PP2A-C
type: Protein
entity reference: PP2A-C
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa10 229
feature: ACTIVE 38
comment: SPECIES_TYPE=PROTEIN

uniprot P47197 135
type: UnificationXref
id: P47197
db: uniprot

PTHR24070:SF264
type: RelationshipXref
id: PTHR24070:SF264
db: PANTHER Family
relationship type: By Homology

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot A0A3Q1NH21 115
organism: Bos taurus

uniprot A0A3Q1NH21 115
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

uniprot F1MBG5 53
type: UnificationXref
id: F1MBG5
db: uniprot

uniprot G3X6J7 99
type: UnificationXref
id: G3X6J7
db: uniprot

uniprot P54619 71
type: UnificationXref
id: P54619
db: uniprot

Tumor protein 63
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot O88898 103
organism: Mus musculus

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F7FN64 97
organism: Macaca mulatta

GTP-binding protein Rheb
type: ProteinReference
xref: PTHR24070:SF264
xref: uniprot F2Z4I1 145
organism: Bos taurus

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 193

uniprot F7GTI4 63
type: UnificationXref
id: F7GTI4
db: uniprot

PTHR24351:SF48
type: RelationshipXref
id: PTHR24351:SF48
db: PANTHER Family
relationship type: By Homology

uniprot F6QE96 123
type: UnificationXref
id: F6QE96
db: uniprot

PTHR12669:SF14
type: RelationshipXref
id: PTHR12669:SF14
db: PANTHER Family
relationship type: By Homology

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot K7CDC2 130
organism: Pan troglodytes

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot F1P4J0 13
organism: Gallus gallus

ncbitaxon 6945 157
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot B1WB72 117
type: UnificationXref
id: B1WB72
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR15154:SF2
xref: uniprot F6Y6G0 204
organism: Macaca mulatta

eco ECO:0000304 93
type: UnificationXref
id: ECO:0000304
db: eco

S15 p53 s28 a39 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S15
feature location: S15 p53 s28 a39 rs1 S15
comment: MODIFICATION_RESIDUE_NAME=S15
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Ribosomal protein S6 kinase beta-2
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot Q9UBS0 36
organism: Homo sapiens

uniprot F7C5U8 40
type: UnificationXref
id: F7C5U8
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q2PUH1 81
organism: Gallus gallus

Protein kinase AMP-activated non-catalytic subunit beta 2
type: ProteinReference
xref: uniprot E2R145 51
organism: Canis lupus familiaris

Danio rerio
type: BioSource
xref: ncbitaxon 7955 3

STATE_TRANSITION_LEFT__S6K-RIGHT__S6K-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 241
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 240
left: S6K
interaction type: STATE_TRANSITION
right: S6K

TSC2 s36 a12 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9QZH4 86
type: UnificationXref
id: Q9QZH4
db: uniprot

PARTICIPANT STOICHIOMETRY re5 249
type: Stoichiometry
physical entity: Complex (TSC2/TSC1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 248
type: Stoichiometry
physical entity: TSC2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 247
type: Stoichiometry
physical entity: TSC1
stoichiometric coefficient: 1.0

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P10361 106
xref: PTHR11447:SF6
organism: Rattus norvegicus

PP2A-C
type: ProteinReference
xref: P04643
standard name: Protein phosphatase 2 catalytic subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein phosphatase 2 catalytic subunit Synonym: Synonym not specified Accession: P04643
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.PP2A-C
member entity reference: Serine/threonine-protein phosphatase
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
member entity reference: Serine/threonine-protein phosphatase PP2A catalytic subunit
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
member entity reference: Serine/threonine-protein phosphatase PP2A
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit A
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit

5'-AMP-activated protein kinase catalytic subunit alpha-2
type: ProteinReference
xref: uniprot Q09137 77
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot F7CQS0 22
organism: Macaca mulatta

5'-AMP-activated protein kinase subunit beta-1
type: ProteinReference
xref: uniprot G2HGR1 65
organism: Pan troglodytes

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot O15350 102
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re15 258
type: Stoichiometry
physical entity: PP2A-C
stoichiometric coefficient: 1.0

uniprot A0A167VDT2 89
type: UnificationXref
id: A0A167VDT2
db: uniprot

uniprot A0A3Q2U4X3 116
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

PARTICIPANT STOICHIOMETRY re15 259
type: Stoichiometry
physical entity: alpha4
stoichiometric coefficient: 1.0

TRANSCRIPTION
type: RelationshipTypeVocabulary

uniprot P54646 73
type: UnificationXref
id: P54646
db: uniprot

GTP s12 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AMPK-_AMP-RIGHT__Complex__AMP_AMPK_-_re1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 262
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 261
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 263
left: AMP
left: AMPK
interaction type: HETERODIMER_ASSOCIATION
right: Complex (AMP/AMPK)

uniprot F6PM85 209
type: UnificationXref
id: F6PM85
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V748 196
xref: PTHR10063:SF0
organism: Macaca mulatta

uniprot F6XP81 127
type: UnificationXref
id: F6XP81
db: uniprot

4E BP1 s21 a29 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

By Homology
type: RelationshipTypeVocabulary

uniprot Q61249 202
type: UnificationXref
id: Q61249
db: uniprot

Serine/threonine-protein phosphatase PP2A catalytic subunit
type: ProteinReference
xref: uniprot Q9HFQ2 188
organism: Emericella nidulans

Serine/threonine-protein kinase STK11
type: ProteinReference
xref: uniprot Q15831 212
organism: Homo sapiens

Immunoglobulin-binding protein 1
type: ProteinReference
xref: PTHR10933:SF11
xref: uniprot Q61249 202
organism: Mus musculus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 191

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q9R078 87
type: UnificationXref
id: Q9R078
db: uniprot

P04646
type: UnificationXref
id: P04646
db: PANTHER Pathway Component

GTP-binding protein Rheb homolog
type: ProteinReference
xref: uniprot Q9VND8 149
organism: Drosophila melanogaster

P04647
type: UnificationXref
id: P04647
db: PANTHER Pathway Component

uniprot F1Q6Z7 162
type: UnificationXref
id: F1Q6Z7
db: uniprot

Serine/threonine-protein kinase Tor
type: ProteinReference
xref: uniprot Q9VK45 46
xref: PTHR11139:SF9
organism: Drosophila melanogaster

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XP81 127
xref: PTHR24356:SF171
organism: Xenopus tropicalis

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 93

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot P67999 30
xref: PTHR24351:SF48
organism: Rattus norvegicus

uniprot Q9Z136 207
type: UnificationXref
id: Q9Z136
db: uniprot

TSC1
type: ProteinReference
xref: P04645
standard name: Tuberous sclerosis 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: TSC1 Synonym: Tuberous sclerosis-1 Accession: P04645
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.TSC1
member entity reference: Hamartin
member entity reference: Uncharacterized protein
member entity reference: TSC complex subunit 1

uniprot Q62622 45
type: UnificationXref
id: Q62622
db: uniprot

uniprot F1Q4F8 122
type: UnificationXref
id: F1Q4F8
db: uniprot

P04645
type: UnificationXref
id: P04645
db: PANTHER Pathway Component

uniprot H2QRH7 170
type: UnificationXref
id: H2QRH7
db: uniprot

5'-AMP-activated protein kinase subunit beta-2
type: ProteinReference
xref: uniprot Q6PAM0 84
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6YST6 60
organism: Ornithorhynchus anatinus

P04644
type: UnificationXref
id: P04644
db: PANTHER Pathway Component

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7BFG2 61
organism: Monodelphis domestica

P04643
type: UnificationXref
id: P04643
db: PANTHER Pathway Component

P04642
type: UnificationXref
id: P04642
db: PANTHER Pathway Component

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 151

P04641
type: UnificationXref
id: P04641
db: PANTHER Pathway Component

ncbitaxon 5786 161
type: UnificationXref
id: 5786
db: ncbitaxon

P04640
type: UnificationXref
id: P04640
db: PANTHER Pathway Component

ncbitaxon 13616 21
type: UnificationXref
id: 13616
db: ncbitaxon

P04639
type: UnificationXref
id: P04639
db: PANTHER Pathway Component

P04637
type: UnificationXref
id: P04637
db: PANTHER Pathway Component

P04638
type: UnificationXref
id: P04638
db: PANTHER Pathway Component

P04636
type: UnificationXref
id: P04636
db: PANTHER Pathway Component

uniprot F6UK84 18
type: UnificationXref
id: F6UK84
db: uniprot

Complex (Rheb/GDP)
type: Complex
component stoichiometry: Rheb s13 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s14 sa8 STOICHIOMETRY ID COMPLEX
component: Rheb
component: GDP
feature: COMPLEX BINDING FEATURE s16 a23 232
feature: COMPLEX BINDING FEATURE s16 a23 230

uniprot Q9H3D4 111
type: UnificationXref
id: Q9H3D4
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 5

PTHR45619:SF42
type: RelationshipXref
id: PTHR45619:SF42
db: PANTHER Family
relationship type: By Homology

uniprot F1PRG4 121
type: UnificationXref
id: F1PRG4
db: uniprot

ncbitaxon 227321 189
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q2LAI0 80
type: UnificationXref
id: Q2LAI0
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot A7T2Q5 150
organism: Nematostella vectensis

5'-AMP-activated protein kinase subunit gamma-1
type: ProteinReference
xref: uniprot P80385 75
organism: Rattus norvegicus

5'-AMP-activated protein kinase subunit beta-1
type: ProteinReference
xref: uniprot P80386 76
organism: Rattus norvegicus

uniprot E2R7K9 10
type: UnificationXref
id: E2R7K9
db: uniprot

Serine/threonine-protein phosphatase PP2A
type: ProteinReference
xref: uniprot P23696 171
xref: PTHR45619:SF12
organism: Drosophila melanogaster

PTHR45619:SF44
type: RelationshipXref
id: PTHR45619:SF44
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

IDA
type: EvidenceCodeVocabulary

uniprot P62715 176
type: UnificationXref
id: P62715
db: uniprot

AMPK s5 a9 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11447:SF21
type: RelationshipXref
id: PTHR11447:SF21
db: PANTHER Family
relationship type: By Homology

DISSOCIATION_LEFT__Complex__TSC2_TSC1_-RIGHT__TSC1-_TSC2-_re24
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 276
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 277
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 278
left: Complex (TSC2/TSC1)
interaction type: DISSOCIATION
right: TSC2
right: TSC1

uniprot W4ZAK5 192
type: UnificationXref
id: W4ZAK5
db: uniprot

uniprot Q6GLE6 184
type: UnificationXref
id: Q6GLE6
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot E9QG65 92
organism: Danio rerio

uniprot H2Q486 24
type: UnificationXref
id: H2Q486
db: uniprot

uniprot F6ZGN9 210
type: UnificationXref
id: F6ZGN9
db: uniprot

alpha4
type: Protein
entity reference: alpha4
feature: ACTIVE 38
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

uniprot Q9HFQ2 188
type: UnificationXref
id: Q9HFQ2
db: uniprot

ncbitaxon 9258 17
type: UnificationXref
id: 9258
db: ncbitaxon

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P02340 104
xref: PTHR11447:SF6
organism: Mus musculus

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q17941 136
organism: Caenorhabditis elegans

uniprot Q9Y243 144
type: UnificationXref
id: Q9Y243
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P67775 181
xref: PTHR45619:SF42
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P67774 180
xref: PTHR45619:SF42
organism: Bos taurus

ncbitaxon 10116 5
type: UnificationXref
id: 10116
db: ncbitaxon

5'-AMP-activated protein kinase catalytic subunit alpha-2
type: ProteinReference
xref: uniprot P54646 73
organism: Homo sapiens

uniprot F1MKA9 94
type: UnificationXref
id: F1MKA9
db: uniprot

5'-AMP-activated protein kinase catalytic subunit alpha-1
type: ProteinReference
xref: uniprot P54645 72
organism: Rattus norvegicus

uniprot F7BFG2 61
type: UnificationXref
id: F7BFG2
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

Serine/threonine-protein kinase STK11
type: ProteinReference
xref: uniprot Q9WTK7 213
xref: PTHR43895:SF25
organism: Mus musculus

Serine/threonine-protein phosphatase PP2A catalytic subunit
type: ProteinReference
xref: uniprot P48580 173
organism: Neurospora crassa

AMPK
type: Protein
entity reference: AMPK
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa11 223
feature: AMPK s38 sa11 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot F7BTW0 20
type: UnificationXref
id: F7BTW0
db: uniprot

alpha4
type: Protein
entity reference: alpha4
comment: SPECIES_TYPE=PROTEIN

Insulin signaling pathway
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF200
xref: uniprot G3X7B5 129
organism: Bos taurus

mTOR
type: ProteinReference
xref: P04638
standard name: mammalian target of rapamycin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Target of rapamycin Synonym: FKBP12-rapamycin complex associated protein 1,FRAP1,TOR Accession: P04638
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.mTOR
member entity reference: Serine/threonine-protein kinase Tor

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1MYJ4 120
organism: Bos taurus

uniprot Q5EG47 83
type: UnificationXref
id: Q5EG47
db: uniprot

uniprot Q29537 110
type: UnificationXref
id: Q29537
db: uniprot

AMPK s8 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AMPK
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot F7CP86 165
organism: Monodelphis domestica

HETERODIMER_ASSOCIATION_LEFT__AMPK-_ATP-RIGHT__Complex__AMPK_ATP_-_re22
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 279
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 281
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 280
left: ATP
left: AMPK
interaction type: HETERODIMER_ASSOCIATION
right: Complex (AMPK/ATP)

Rheb s13 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rheb
stoichiometric coefficient: 1.0

5'-AMP-activated protein kinase subunit gamma-1 isoform 1
type: ProteinReference
xref: uniprot H9EQE8 68
organism: Macaca mulatta

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

p53 pathway
type: Pathway

uniprot P63331 179
type: UnificationXref
id: P63331
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 161

PARTICIPANT STOICHIOMETRY re10 267
type: Stoichiometry
physical entity: 4E-BP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 266
type: Stoichiometry
physical entity: 4E-BP1
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RJX4 118
xref: PTHR24356:SF171
organism: Canis lupus familiaris

alpha4
type: ProteinReference
xref: P04646
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.alpha4
comment: ENTITY_REFERENCE_NOTES=Long Name: alpha4 Synonym: Synonym not specified Accession: P04646
member entity reference: Immunoglobulin-binding protein 1

uniprot Q60823 138
type: UnificationXref
id: Q60823
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Rheb_GTP_-RIGHT__Pi-_Complex__Rheb_GDP_-_re7
controller: Complex (TSC2/TSC1)

uniprot A0A2I3TVR3 49
type: UnificationXref
id: A0A2I3TVR3
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A8X0Q9 152
organism: Caenorhabditis briggsae

PTHR45619:SF12
type: RelationshipXref
id: PTHR45619:SF12
db: PANTHER Family
relationship type: By Homology

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1Q4F8 122
organism: Canis lupus familiaris

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q2LAI0 80
organism: Gallus gallus

uniprot Q5BIS9 82
type: UnificationXref
id: Q5BIS9
db: uniprot

uniprot H9EQE8 68
type: UnificationXref
id: H9EQE8
db: uniprot

uniprot Q6TJY3 31
type: UnificationXref
id: Q6TJY3
db: uniprot

S6K
type: Protein
entity reference: S6K
feature: S6K s18 a27 rs1
feature: ACTIVE 38
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Complex__AMP_AMPK_-RIGHT__AMPK-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 255
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 254
left: Complex (AMP/AMPK)
interaction type: STATE_TRANSITION
right: AMPK

PP2A-C
type: Protein
entity reference: PP2A-C
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot C3XQF4 158
organism: Branchiostoma floridae

uniprot E1BNT2 194
type: UnificationXref
id: E1BNT2
db: uniprot

PARTICIPANT STOICHIOMETRY re22 279
type: Stoichiometry
physical entity: AMPK
stoichiometric coefficient: 1.0

uniprot P80386 76
type: UnificationXref
id: P80386
db: uniprot

S15 p53 s27 a38 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S15
feature location: S15 p53 s27 a38 rs1 S15
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S15
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot H2QDK7 26
type: UnificationXref
id: H2QDK7
db: uniprot

uniprot P80385 75
type: UnificationXref
id: P80385
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TSC2-RIGHT__TSC2-_re4
controller: AMPK

uniprot Q6PAM0 84
type: UnificationXref
id: Q6PAM0
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot Q7PD38 186
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY re15 260
type: Stoichiometry
physical entity: Complex (alpha4/PP2A-C)
stoichiometric coefficient: 1.0

uniprot Q9JJP6 113
type: UnificationXref
id: Q9JJP6
db: uniprot

LKB1
type: ProteinReference
xref: P04647
standard name: Serine/threonine protein kinase 11
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Serine/threonine protein kinase 11 Synonym: STK11 Accession: P04647
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway by glucose deprivation.PROTEIN.GENERIC.LKB1
member entity reference: Serine/threonine kinase 11
member entity reference: Serine/threonine-protein kinase STK11
member entity reference: Uncharacterized protein

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F7BTW0 20
xref: PTHR24351:SF48
organism: Monodelphis domestica

uniprot F2Z4I1 145
type: UnificationXref
id: F2Z4I1
db: uniprot

5'-AMP-activated protein kinase subunit beta-1
type: ProteinReference
xref: uniprot Q5BIS9 82
organism: Bos taurus

uniprot P31749 131
type: UnificationXref
id: P31749
db: uniprot

5'-AMP-activated protein kinase subunit beta-1
type: ProteinReference
xref: uniprot Q9R078 87
organism: Mus musculus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot B3S653 154
organism: Trichoplax adhaerens

PANTHER Pathway P04397 1
type: UnificationXref
id: P04397
db: PANTHER Pathway

uniprot H9ENT4 27
type: UnificationXref
id: H9ENT4
db: uniprot

S6K s18 a27 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9JJP2 112
type: UnificationXref
id: Q9JJP2
db: uniprot

PARTICIPANT STOICHIOMETRY re22 280
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 189

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P67939 108
xref: PTHR11447:SF6
organism: Bos taurus

uniprot P67939 108
type: UnificationXref
id: P67939
db: uniprot

PARTICIPANT STOICHIOMETRY re22 281
type: Stoichiometry
physical entity: Complex (AMPK/ATP)
stoichiometric coefficient: 1.0

uniprot P54645 72
type: UnificationXref
id: P54645
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__TSC2_TSC1_-RIGHT__TSC1-_TSC2-_re24
controller: Akt

5'-AMP-activated protein kinase subunit beta-2
type: ProteinReference
xref: uniprot A0A1D5QWE9 47
organism: Macaca mulatta

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__TSC2-RIGHT__TSC2-_re32
control type: ACTIVATION
controller: p53

PARTICIPANT STOICHIOMETRY re9 240
type: Stoichiometry
physical entity: S6K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 241
type: Stoichiometry
physical entity: S6K
stoichiometric coefficient: 1.0