Phosphatidylinositol 3-kinase catalytic subunit type 3
Phosphoinositide-3-kinase regulatory subunit 1
Non-specific serine/threonine protein kinase
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
MODEL_NOTES=Panther Pathway: P04398 The p53 transcription factor is the key gatekeeper in the cellular response to stress signals. Different stresses result in different post-translational modifications to p53 that lead to one of three different types of cellular response: cell cycle arrest, cellular senescence or apoptosis. The p53 pathway is therefore connected by feedback loops, both negative and positive, to a number of other pathways as sensors of cellular state. Most of these loops connect to Mdm2, which regulates p53 by binding and ubiquitinating it, marking it for degradation. The p53 circuit forms autoregulatory loops with the Wnt-beta-catenin, IGF-1-AKT, Rb-E2F, p38 MAP kinase, cyclin-cdk, p14/19 ARF pathways and the cyclin G-PP2A, and p73 gene products. Most of these are represented here. Medline=15720184 Medline=15838523 Medline=9039259 PMID: 15720184 PMID: 15838523 PMID: 9039259
Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
ENTITY_REFERENCE_NOTES= Long Name: p38 MAPK Synonym: p38,p38MAPK Accession: P04648
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.p38 MAPK
3-phosphoinositide dependent protein kinase 1
ENTITY_REFERENCE_NOTES= Long Name: Rb Synonym: Synonym not specified Accession: P04654
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.Rb
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.p21
ENTITY_REFERENCE_NOTES= Long Name: p21 Synonym: p21CIP1,p21WAF1 Accession: P04667
Phosphatidylinositol 3-kinase regulatory subunit gamma
Phosphoinositide-3-kinase regulatory subunit 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
ENTITY_REFERENCE_NOTES= Long Name: P110alpha Synonym: P110-alpha,PIK3CA Accession: P04657
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.P110alpha
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.AKT
ENTITY_REFERENCE_NOTES= Long Name: AKT Synonym: ONCOGENE AKT1,ONCOGENE AKT2,PKB,PKB-ALPHA,PKB-BETA,PROTEIN KINASE B-ALPHA,PROTEIN KINASE B-BETA,RAC SERINE/THREONINE PROTEIN KINASE Accession: P04665 Pathway Link: P00033|P00894|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04641|p53 pathway by glucose deprivation*P00059|P01486|p53 pathway
v-myc myelocytomatosis viral oncogene homolog
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.Myc
ENTITY_REFERENCE_NOTES= Long Name: Myc Synonym: c-myc Accession: P04649
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.P21
ENTITY_REFERENCE_NOTES= Long Name: P21 Synonym: p21CIP1,p21WAF1 Accession: G04712
Signal transducer and activator of transcription 1
ENTITY_REFERENCE_NOTES= Long Name: E2F-1 Synonym: Transcription factor E2F Accession: P04652
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.E2F-1
Phosphatidylinositol 3-kinase regulatory subunit beta
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.SIAH-1
ENTITY_REFERENCE_NOTES= Long Name: SIAH-1 Synonym: Synonym not specified Accession: G04711
Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Phosphoinositide-3-kinase regulatory subunit 5
RAC-beta serine/threonine-protein kinase
ENTITY_REFERENCE_NOTES= Long Name: ATM Synonym: Synonym not specified Accession: P04669
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.ATM
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.PTEN
ENTITY_REFERENCE_NOTES= Long Name: PTEN Synonym: Synonym not specified Accession: P04658
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
ENTITY_REFERENCE_NOTES= Long Name: cyclin G Synonym: CCNG,Cyclin G1 Accession: P04662
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.cyclin G
3-phosphoinositide-dependent protein kinase 1
Phosphoinositide-3-kinase regulatory subunit 2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
ENTITY_REFERENCE_NOTES= Long Name: PI3K Synonym: PI3-K,PI3K,Phosphoinositide 3-OH-kinase,Phosphoinositide 3-kinase Accession: P04661
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.PI3K
Catenin (Cadherin-associated protein), beta 1, 88kDa
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Serine/threonine-protein phosphatase PP2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.P110ALPHA
ENTITY_REFERENCE_NOTES= Long Name: P110ALPHA Synonym: P110-alpha,PIK3CA Accession: G04707
-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Phosphatidylinositol 3-kinase regulatory subunit alpha
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.PTEN
ENTITY_REFERENCE_NOTES= Long Name: PTEN Synonym: Synonym not specified Accession: G04714
ENTITY_REFERENCE_NOTES= Long Name: MDM-2 Synonym: Synonym not specified Accession: G04709
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.MDM-2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
3-phosphoinositide-dependent protein kinase 1 and 2
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.PDK1/2
ENTITY_REFERENCE_NOTES= Long Name: PDK1/2 Synonym: Synonym not specified Accession: P04656
Kirsten rat sarcoma viral oncogene homolog
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.p53
ENTITY_REFERENCE_NOTES= Long Name: p53 Synonym: Synonym not specified Accession: P04668 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04392|P04539|P53 pathway feedback loops 1*P00059|P01485|p53 pathway
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.cdk2
RAC-gamma serine/threonine-protein kinase
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.beta-catenin
ENTITY_REFERENCE_NOTES= Long Name: beta-catenin Synonym: CADHERIN-ASSOCIATED PROTEIN, BETA,CATENIN, BETA-1,CTNNB,CTNNB1 Accession: P04670
RAC-alpha serine/threonine-protein kinase
Putative tyrosine-protein phosphatase TPTE
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.PP2A-C
ENTITY_REFERENCE_NOTES= Long Name: PP2A-C Synonym: Synonym not specified Accession: P04659
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.cyclin A
V-HA-RAS HARVEY RAT SARCOMA VIRAL ONCOGENE HOMOLOG HRAS
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.Ras
ENTITY_REFERENCE_NOTES= Long Name: V-HA-RAS HARVEY RAT SARCOMA VIRAL ONCOGENE HOMOLOG HRAS Synonym: HRAS1 Accession: P04651
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.CYCLIN G
ENTITY_REFERENCE_NOTES= Long Name: CYCLIN G Synonym: CCNG,Cyclin G1 Accession: G04715
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Neuroblastoma RAS viral (v-ras) oncogene homolog
Signal transducer and activator of transcription
Serine/threonine-protein phosphatase 2A catalytic subunit A
Serine/threonine-protein phosphatase 2A catalytic subunit
ENTITY_REFERENCE_NOTES= Long Name: SIAH-1 Synonym: Synonym not specified Accession: P04660
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.SIAH-1
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.cyclin E
Serine/threonine-protein phosphatase PP2A catalytic subunit
Phosphatidylinositol 3-kinase VPS34-like
Phosphoinositide 3-kinase regulatory subunit 5
ENTITY_REFERENCE_NOTES= Long Name: WIP-1 Synonym: PPM1D,protein phosphatase, magnesium-dependent, 1, delta isoform Accession: G04708
ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.WIP-1
Harvey rat sarcoma viral oncogene homolog
Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1