HETERODIMER_ASSOCIATION_LEFT__p53-_MDM_2-RIGHT__Complex__p53_MDM_2_-_re104
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re104 498
participant stoichiometry: PARTICIPANT STOICHIOMETRY re104 497
participant stoichiometry: PARTICIPANT STOICHIOMETRY re104 496
left: p53
left: MDM-2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (p53/MDM-2)

UVSB
type: ProteinReference
xref: uniprot C8VB89 402
organism: Emericella nidulans

uniprot P47794 327
type: UnificationXref
id: P47794
db: uniprot

cyclin G
type: Protein
entity reference: cyclin G
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

P04670
type: UnificationXref
id: P04670
db: PANTHER Pathway Component

uniprot A0A2I3T7A8 145
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

uniprot Q61411 97
type: UnificationXref
id: Q61411
db: uniprot

uniprot P54676 292
type: UnificationXref
id: P54676
db: uniprot

Retinoblastoma-like protein 1
type: ProteinReference
xref: uniprot Q64701 123
organism: Mus musculus

uniprot A0A2J8MGP0 229
type: UnificationXref
id: A0A2J8MGP0
db: uniprot

P04669
type: UnificationXref
id: P04669
db: PANTHER Pathway Component

uniprot Q9JKK8 417
type: UnificationXref
id: Q9JKK8
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6SZ66 249
xref: PTHR10048:SF7
organism: Monodelphis domestica

P04668
type: UnificationXref
id: P04668
db: PANTHER Pathway Component

ncbitaxon 10090 24
type: UnificationXref
id: 10090
db: ncbitaxon

STATE_TRANSITION_LEFT__beta_catenin-RIGHT__a129_degraded-_re96
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re96 530
participant stoichiometry: PARTICIPANT STOICHIOMETRY re96 531
left: beta-catenin
interaction type: STATE_TRANSITION
right: a129_degraded

STATE_TRANSITION_LEFT__MDM_2-RIGHT__a132_degraded-_re98
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re98 527
participant stoichiometry: PARTICIPANT STOICHIOMETRY re98 526
left: MDM-2
interaction type: STATE_TRANSITION
right: a132_degraded

Protein kinase rad3
type: ProteinReference
xref: uniprot Q02099 413
xref: PTHR11139:SF69
organism: Schizosaccharomyces pombe

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

Tumor protein 63
type: ProteinReference
xref: uniprot Q9H3D4 398
xref: PTHR11447:SF8
organism: Homo sapiens

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

uniprot F1PHV7 73
type: UnificationXref
id: F1PHV7
db: uniprot

uniprot Q9WUI1 44
type: UnificationXref
id: Q9WUI1
db: uniprot

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

MDM-2
type: Protein
feature: MDM 2 s37 sa17 rs3
feature: MDM 2 s37 sa17 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa17 442
feature: ACTIVE 46
feature: MDM 2 s37 sa17 rs2
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F1Q2Q9 247
organism: Canis lupus familiaris

ncbitaxon 9258 49
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot F7HT00 408
type: UnificationXref
id: F7HT00
db: uniprot

RB transcriptional corepressor 1
type: ProteinReference
xref: uniprot H2Q7K0 117
organism: Pan troglodytes

uniprot D3ZTF6 235
type: UnificationXref
id: D3ZTF6
db: uniprot

Os01g0872800 protein
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q8RUE8 136
organism: Oryza sativa

Mus musculus
type: BioSource
xref: ncbitaxon 10090 24

uniprot P42336 153
type: UnificationXref
id: P42336
db: uniprot

ncbitaxon 6239 88
type: UnificationXref
id: 6239
db: ncbitaxon

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q7QK56 354
organism: Anopheles gambiae

uniprot P01116 83
type: UnificationXref
id: P01116
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7C798 19
xref: PTHR24055:SF109
organism: Macaca mulatta

cdk2
type: Protein
entity reference: cdk2
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa4 436
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 13616 14
type: UnificationXref
id: 13616
db: ncbitaxon

ACTIVE 46
type: EntityFeature
comment: Active state

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot A0A2I3T9Y4 330
organism: Pan troglodytes

cyclin G s15 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cyclin G
stoichiometric coefficient: 1.0

p53 s30 a74 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot E2RIF9 241
type: UnificationXref
id: E2RIF9
db: uniprot

uniprot K7CDC2 346
type: UnificationXref
id: K7CDC2
db: uniprot

uniprot A0A2I3TRY9 228
type: UnificationXref
id: A0A2I3TRY9
db: uniprot

Cyclin-dependent kinase inhibitor 1A
type: ProteinReference
xref: PTHR46778:SF1
xref: uniprot Q64315 376
organism: Rattus norvegicus

SIAH-1
type: DnaRegion
entity reference: Seven in absentia homolog 1
cellular location: nucleus
comment: SPECIES_TYPE=GENE

p21
type: Protein
entity reference: p21
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa5 438
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Complex (cyclin G/PP2A-C)
type: Complex
component stoichiometry: cyclin G s15 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: PP2A C s16 sa11 STOICHIOMETRY ID COMPLEX
component: PP2A-C
component: cyclin G
feature: COMPLEX BINDING FEATURE s42 a88 457
feature: ACTIVE 46
feature: COMPLEX BINDING FEATURE s42 a88 455
cellular location: nucleus

uniprot Q503B6 95
type: UnificationXref
id: Q503B6
db: uniprot

uniprot A0A2I3T9Y4 330
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__P14_19_ARF-RIGHT__p14_p19_ARF-_re111
control type: ACTIVATION
controller: E2F-1

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot O08586 163
organism: Mus musculus

uniprot G3V802 364
type: UnificationXref
id: G3V802
db: uniprot

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

p53 pathway feedback loops 2
type: Pathway
pathway component: TRANSCRIPTION_LEFT__P14_19_ARF-RIGHT__p14_p19_ARF-_re111
pathway component: STATE_TRANSITION_LEFT__Rb-RIGHT__Rb-_re35
pathway component: TRANSCRIPTION_LEFT__CYCLIN_G-RIGHT__CYCLIN_G-_re119
pathway component: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re79
pathway component: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re101
pathway component: STATE_TRANSITION_LEFT__PIP_2-RIGHT__PIP_3-_re81
pathway component: STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_re83
pathway component: TRANSCRIPTION_LEFT__pro_apoptotic_genes-RIGHT__pro_apoptotic_genes-_re116
pathway component: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re34
pathway component: STATE_TRANSITION_LEFT__p38_MAPK-RIGHT__p38_MAPK-_re46
pathway component: STATE_TRANSITION_LEFT__MDM_2-RIGHT__a132_degraded-_re98
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__DNA_damage-RIGHT__ATM-_re70
pathway component: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__a129_degraded-_re96
pathway component: PHYSICAL_STIMULATION
pathway component: TRANSLATION_LEFT__p14_p19_ARF-RIGHT__p14_19_ARF-_re112
pathway component: TRANSCRIPTION_LEFT__SIAH_1-RIGHT__SIAH_1-_re107
pathway component: TRANSLATION_LEFT__P110ALPHA-RIGHT__P110alpha-_re122
pathway component: TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re123
pathway component: HETERODIMER_ASSOCIATION_LEFT__p53-_MDM_2-RIGHT__Complex__p53_MDM_2_-_re104
pathway component: HETERODIMER_ASSOCIATION_LEFT__Rb-_MDM_2-RIGHT__Complex__MDM_2_Rb_-_re37
pathway component: STATE_TRANSITION_LEFT__PIP_3-RIGHT__PIP_2-_re82
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Insulin_IGF_signaling_pathway-RIGHT__PI3K-_re89
pathway component: STATE_TRANSITION_LEFT__p38_MAPK-RIGHT__p38_MAPK-_re47
pathway component: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re100
pathway component: STATE_TRANSITION_LEFT__p53-RIGHT__a94_degraded-_re57
pathway component: TRANSLATION_LEFT__Wip_1-RIGHT__Wip1-_re110
pathway component: TRANSCRIPTION_LEFT__P110ALPHA-RIGHT__P110ALPHA-_re121
pathway component: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re102
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Ras_pathway-RIGHT__Ras-_re68
pathway component: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re52
pathway component: HETERODIMER_ASSOCIATION_LEFT__p14_19_ARF-_MDM_2-RIGHT__Complex__p14_19_ARF__MDM_2_-_re63
pathway component: TRANSCRIPTION_LEFT__WIP_1-RIGHT__Wip_1-_re109
pathway component: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re95
pathway component: STATE_TRANSITION_LEFT__Complex__p53_MDM_2_-RIGHT__p53-_MDM_2-_re106
pathway component: TRANSLATION_LEFT__P21-RIGHT__p21-_re118
pathway component: STATE_TRANSITION_LEFT__p14_19_ARF-RIGHT__p14_19_ARF-_re125
pathway component: HETERODIMER_ASSOCIATION_LEFT__PI3K-_P110alpha-RIGHT__Complex__PI3K_P110alpha_-_re88
pathway component: TRANSLATION_LEFT__PTEN-RIGHT__PTEN-_re124
pathway component: TRANSLATION_LEFT__MDM_2-RIGHT__MDM_2-_re114
pathway component: HETERODIMER_ASSOCIATION_LEFT__cyclin_G-_PP2A_C-RIGHT__Complex__cyclin_G_PP2A_C_-_re53
pathway component: TRANSCRIPTION_LEFT__P21-RIGHT__P21-_re117
pathway component: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re32
pathway component: TRANSCRIPTION_LEFT__MDM_2-RIGHT__MDM_2-_re113
pathway component: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_re84
pathway component: TRANSLATION_LEFT__CYCLIN_G-RIGHT__cyclin_G-_re120
pathway component: STATE_TRANSITION_LEFT__Complex__p53_MDM_2_-RIGHT__Complex__p53_MDM_2_-_re105
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Wnt_pathway-RIGHT__beta_catenin-_re69
pathway component: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re61
pathway component: HETERODIMER_ASSOCIATION_LEFT__p21-_Complex__cyclin_E_cdk2_-RIGHT__Complex__cyclin_E_cdk2__p21_-_re31
pathway component: TRANSLATION_LEFT__SIAH_1-RIGHT__SIAH_1-_re108
xref: PANTHER Pathway P04398 1
comment: MODEL_NOTES=Panther Pathway: P04398 The p53 transcription factor is the key gatekeeper in the cellular response to stress signals. Different stresses result in different post-translational modifications to p53 that lead to one of three different types of cellular response: cell cycle arrest, cellular senescence or apoptosis. The p53 pathway is therefore connected by feedback loops, both negative and positive, to a number of other pathways as sensors of cellular state. Most of these loops connect to Mdm2, which regulates p53 by binding and ubiquitinating it, marking it for degradation. The p53 circuit forms autoregulatory loops with the Wnt-beta-catenin, IGF-1-AKT, Rb-E2F, p38 MAP kinase, cyclin-cdk, p14/19 ARF pathways and the cyclin G-PP2A, and p73 gene products. Most of these are represented here. Medline=15720184 Medline=15838523 Medline=9039259 PMID: 15720184 PMID: 15838523 PMID: 9039259

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot F1MBU9 245
organism: Bos taurus

MDM 2 s37 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot F1MKA9 381
xref: PTHR11447:SF8
organism: Bos taurus

uniprot Q64143 297
type: UnificationXref
id: Q64143
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q8NEB9 304
organism: Homo sapiens

S33 p53 s48 sa18 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S33
feature location: S33 p53 s48 sa18 rs2 S33
comment: MODIFICATION_RESIDUE_ANGLE=2.3412474663214593
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S33

Protein Mdm4
type: DnaReference
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Canis lupus familiaris

uniprot F1NJI2 360
type: UnificationXref
id: F1NJI2
db: uniprot

uniprot Q9W1M7 310
type: UnificationXref
id: Q9W1M7
db: uniprot

p38 MAPK
type: ProteinReference
xref: P04648
standard name: p38 mitogen activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: p38 MAPK Synonym: p38,p38MAPK Accession: P04648
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.p38 MAPK
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase 14B
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase p38b
member entity reference: Mitogen-activated protein kinase 14A

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Bos taurus

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot G3X6J7 386
organism: Bos taurus

AKT s64 a116 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

SIAH-1
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P56424 394
xref: PTHR11447:SF6
organism: Macaca mulatta

MDM-2
type: Protein
feature: MDM 2 s14 a60 rs1
feature: MDM 2 s14 a60 rs2
feature: MDM 2 s14 a60 rs3
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 196

PARTICIPANT STOICHIOMETRY re35 522
type: Stoichiometry
physical entity: Rb
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re35 523
type: Stoichiometry
physical entity: Rb
stoichiometric coefficient: 1.0

uniprot P38111 412
type: UnificationXref
id: P38111
db: uniprot

Serine/threonine-protein kinase TEL1
type: ProteinReference
xref: uniprot P38110 411
organism: Saccharomyces cerevisiae

Serine/threonine-protein kinase MEC1
type: ProteinReference
xref: uniprot P38111 412
organism: Saccharomyces cerevisiae

ATM
type: Protein
entity reference: ATM
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot A0A2I3TN41 125
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__P21-RIGHT__P21-_re117
control type: ACTIVATION
controller: p53

NRAS protein
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot A5D7R9 67
organism: Bos taurus

uniprot P51943 368
type: UnificationXref
id: P51943
db: uniprot

uniprot P27986 284
type: UnificationXref
id: P27986
db: uniprot

p38 MAPK
type: Protein
entity reference: p38 MAPK
feature: p38 MAPK s35 a71 rs1
feature: ACTIVE 46
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Protein Mdm4
type: DnaReference
organism: Mus musculus

uniprot P01106 53
type: UnificationXref
id: P01106
db: uniprot

Rb
type: Protein
entity reference: Rb
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa7 450
feature: Rb s18 sa7 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

E3 ubiquitin-protein ligase SIAH1A
type: DnaReference
xref: PTHR45877:SF1
organism: Mus musculus

E3 ubiquitin-protein ligase SIAH1B
type: DnaReference
xref: PTHR45877:SF1
organism: Mus musculus

PTHR12081:SF44
type: RelationshipXref
id: PTHR12081:SF44
db: PANTHER Family
relationship type: By Homology

uniprot H2PZQ7 80
type: UnificationXref
id: H2PZQ7
db: uniprot

Rb
type: ProteinReference
xref: P04654
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Rb Synonym: Synonym not specified Accession: P04654
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.Rb
member entity reference: Retinoblastoma-like protein 1
member entity reference: RB transcriptional corepressor-like 1
member entity reference: Uncharacterized protein
member entity reference: RB transcriptional corepressor like 1
member entity reference: Retinoblastoma-associated protein
member entity reference: RB transcriptional corepressor 1

STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 540
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 541
left: p53
interaction type: STATE_TRANSITION
right: p53

uniprot P02340 391
type: UnificationXref
id: P02340
db: uniprot

PTEN
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

AKT
type: Protein
entity reference: AKT
feature: AKT s65 a117 rs1
feature: ACTIVE 46
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot O42376 27
xref: PTHR24055:SF146
organism: Danio rerio

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q9Z1L0 311
organism: Rattus norvegicus

uniprot B1H2U0 156
type: UnificationXref
id: B1H2U0
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P79737 90
organism: Danio rerio

S46 p53 s36 sa16 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S46
feature location: S46 p53 s36 sa16 rs3 S46
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.934482691359872
comment: MODIFICATION_RESIDUE_NAME=S46

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CKQ1 313
xref: PTHR10177:SF59
organism: Macaca mulatta

uniprot Q60823 353
type: UnificationXref
id: Q60823
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Mus musculus

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Rattus norvegicus

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 39

uniprot P70618 33
type: UnificationXref
id: P70618
db: uniprot

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot P09416 56
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__p53-RIGHT__a94_degraded-_re57
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re57 472
participant stoichiometry: PARTICIPANT STOICHIOMETRY re57 471
left: p53
interaction type: STATE_TRANSITION
right: a94_degraded

uniprot Q9WTY9 43
type: UnificationXref
id: Q9WTY9
db: uniprot

uniprot P48463 194
type: UnificationXref
id: P48463
db: uniprot

PARTICIPANT STOICHIOMETRY re89 473
type: Stoichiometry
physical entity: Insulin/IGF signaling pathway
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re89 474
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PTEN
type: DnaRegion
entity reference: phospatase and tensin homologue
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot Q6P365 207
organism: Xenopus tropicalis

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q15759 34
xref: PTHR24055:SF109
organism: Homo sapiens

uniprot P23726 281
type: UnificationXref
id: P23726
db: uniprot

PARTICIPANT STOICHIOMETRY re47 506
type: Stoichiometry
physical entity: p38 MAPK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re47 505
type: Stoichiometry
physical entity: p38 MAPK
stoichiometric coefficient: 1.0

uniprot Q61456 370
type: UnificationXref
id: Q61456
db: uniprot

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TN41 125
type: UnificationXref
id: A0A2I3TN41
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot F1MDX9 158
organism: Bos taurus

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot P23583 57
organism: Pan troglodytes

Ras protein let-60
type: ProteinReference
xref: uniprot P22981 87
xref: PTHR24070:SF420
organism: Caenorhabditis elegans

TRANSLATION_LEFT__MDM_2-RIGHT__MDM_2-_re114
type: TemplateReaction
product: MDM-2
xref: TRANSLATION
participant: MDM-2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot O00459 271
type: UnificationXref
id: O00459
db: uniprot

uniprot W4XIE2 62
type: UnificationXref
id: W4XIE2
db: uniprot

p21
type: ProteinReference
xref: P04667
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.p21
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: p21 Synonym: p21CIP1,p21WAF1 Accession: P04667
member entity reference: Cyclin-dependent kinase inhibitor 1A
member entity reference: Cyclin dependent kinase inhibitor 1A
member entity reference: Cyclin-dependent kinase inhibitor 1

ncbitaxon 8364 48
type: UnificationXref
id: 8364
db: ncbitaxon

ncbitaxon 10228 177
type: UnificationXref
id: 10228
db: ncbitaxon

uniprot P24864 324
type: UnificationXref
id: P24864
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot Q29537 397
organism: Canis lupus familiaris

uniprot H2QKB0 118
type: UnificationXref
id: H2QKB0
db: uniprot

Ras
type: Protein
entity reference: Ras
comment: SPECIES_TYPE=PROTEIN

uniprot F7H808 189
type: UnificationXref
id: F7H808
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RPB0 243
xref: PTHR10155:SF2
organism: Canis lupus familiaris

uniprot W4ZAK5 212
type: UnificationXref
id: W4ZAK5
db: uniprot

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot F1PHV7 73
organism: Canis lupus familiaris

PTHR24356:SF368
type: RelationshipXref
id: PTHR24356:SF368
db: PANTHER Family
relationship type: By Homology

Wnt pathway
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

p53 s48 sa18 rs4
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot F6SFG7 75
type: UnificationXref
id: F6SFG7
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E7EXT6 335
xref: PTHR24356:SF190
organism: Danio rerio

NRAS isoform 1
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot H2PZQ7 80
organism: Pan troglodytes

Cyclin-G1
type: ProteinReference
xref: uniprot Q5E9I1 319
xref: PTHR10177:SF59
organism: Bos taurus

uniprot Q5E9Y0 109
type: UnificationXref
id: Q5E9Y0
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot H2QC53 387
organism: Pan troglodytes

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot O15264 25
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7DUD6 149
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

MDM-2
type: Protein
feature: MDM 2 s68 a120 rs3
feature: MDM 2 s68 a120 rs2
feature: MDM 2 s68 a120 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot A0A167VDT2 377
type: UnificationXref
id: A0A167VDT2
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Macaca mulatta

Complex (p53/MDM-2)
type: Complex
component stoichiometry: p53 s36 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: MDM 2 s37 sa17 STOICHIOMETRY ID COMPLEX
component: MDM-2
component: p53
feature: COMPLEX BINDING FEATURE s88 a141 441
feature: COMPLEX BINDING FEATURE s88 a141 439
cellular location: nucleus

uniprot P22543 280
type: UnificationXref
id: P22543
db: uniprot

G1/S-specific cyclin-E1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot P24864 324
organism: Homo sapiens

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q95NE7 38
organism: Pan troglodytes

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot H2QRH7 192
organism: Pan troglodytes

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q64143 297
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 340
organism: Monodelphis domestica

uniprot Q61457 328
type: UnificationXref
id: Q61457
db: uniprot

uniprot F1MDX9 158
type: UnificationXref
id: F1MDX9
db: uniprot

Protein Mdm4
type: DnaReference
organism: Homo sapiens

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Homo sapiens

uniprot O15350 389
type: UnificationXref
id: O15350
db: uniprot

TRANSCRIPTION_LEFT__pro_apoptotic_genes-RIGHT__pro_apoptotic_genes-_re116
type: TemplateReaction
product: pro-apoptotic genes
xref: TRANSCRIPTION
participant: pro-apoptotic genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot E1BEI6 404
type: UnificationXref
id: E1BEI6
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__WIP_1-RIGHT__Wip_1-_re109
control type: ACTIVATION
controller: p53

P110ALPHA
type: DnaRegion
entity reference: P110ALPHA
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P79734 396
xref: PTHR11447:SF6
organism: Danio rerio

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q04970 91
organism: Rattus norvegicus

uniprot P54673 289
type: UnificationXref
id: P54673
db: uniprot

PTHR24356:SF163
type: RelationshipXref
id: PTHR24356:SF163
db: PANTHER Family
relationship type: By Homology

uniprot P62716 199
type: UnificationXref
id: P62716
db: uniprot

a132_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

uniprot A8X0Q9 175
type: UnificationXref
id: A8X0Q9
db: uniprot

uniprot E9QAN8 244
type: UnificationXref
id: E9QAN8
db: uniprot

MDM 2 s59 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot P60484 167
organism: Homo sapiens

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot P60483 166
organism: Canis lupus familiaris

uniprot Q9JJP6 400
type: UnificationXref
id: Q9JJP6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot F7BEI4 323
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re63 537
type: Stoichiometry
physical entity: Complex (p14/19 ARF/ MDM-2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re63 536
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re63 535
type: Stoichiometry
physical entity: p14/19 ARF
stoichiometric coefficient: 1.0

MDM 2 s22 sa13 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re46 510
type: Stoichiometry
physical entity: p38 MAPK
stoichiometric coefficient: 1.0

Phosphoinositide-3-kinase regulatory subunit 3
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot A0A2I3RH39 225
organism: Pan troglodytes

ncbitaxon 227321 93
type: UnificationXref
id: 227321
db: ncbitaxon

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re32
controller: MDM-2

Cyclin dependent kinase inhibitor 1A
type: DnaReference
xref: PTHR46778:SF1
organism: Pan troglodytes

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__P110ALPHA-RIGHT__P110ALPHA-_re121
control type: INHIBITION
controller: p53

HETERODIMER_ASSOCIATION_LEFT__PI3K-_P110alpha-RIGHT__Complex__PI3K_P110alpha_-_re88
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re88 477
participant stoichiometry: PARTICIPANT STOICHIOMETRY re88 475
participant stoichiometry: PARTICIPANT STOICHIOMETRY re88 476
left: P110alpha
left: PI3K
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PI3K/P110alpha)

cyclin E
type: Protein
entity reference: cyclin E
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 464
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Catenin beta-1
type: ProteinReference
xref: uniprot B6V8E6 419
xref: PTHR45976:SF4
organism: Canis lupus familiaris

MODULATION
type: RelationshipTypeVocabulary

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot B7QGY5 178
organism: Ixodes scapularis

PIK3C2G isoform 2
type: ProteinReference
xref: uniprot A0A2I3S6S7 226
organism: Pan troglodytes

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P04637 392
organism: Homo sapiens

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot F1Q6Z7 184
organism: Danio rerio

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 16

ncbitaxon 45351 174
type: UnificationXref
id: 45351
db: ncbitaxon

00696
type: UnificationXref
id: MOD:00696
db: mod

PARTICIPANT STOICHIOMETRY re46 509
type: Stoichiometry
physical entity: p38 MAPK
stoichiometric coefficient: 1.0

Rb
type: Protein
entity reference: Rb
feature: Rb s24 a63 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q64701 123
type: UnificationXref
id: Q64701
db: uniprot

uniprot Q6P943 61
type: UnificationXref
id: Q6P943
db: uniprot

uniprot O00443 270
type: UnificationXref
id: O00443
db: uniprot

KNOWN_TRANSITION_OMITTED_LEFT__Ras_pathway-RIGHT__Ras-_re68
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re68 521
participant stoichiometry: PARTICIPANT STOICHIOMETRY re68 520
left: Ras pathway
interaction type: KNOWN_TRANSITION_OMITTED
right: Ras

Catenin beta-1
type: ProteinReference
xref: uniprot F7GNE4 424
xref: PTHR45976:SF4
organism: Macaca mulatta

IP16020p
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot Q7KMQ6 168
organism: Drosophila melanogaster

PANTHER Pathway P04398 1
type: UnificationXref
id: P04398
db: PANTHER Pathway

STATE_TRANSITION_LEFT__PIP_3-RIGHT__PIP_2-_re82
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re82 488
participant stoichiometry: PARTICIPANT STOICHIOMETRY re82 487
left: PIP-3
interaction type: STATE_TRANSITION
right: PIP-2

uniprot Q7PD38 208
type: UnificationXref
id: Q7PD38
db: uniprot

uniprot O55173 128
type: UnificationXref
id: O55173
db: uniprot

MCG118205, isoform CRA_c
type: DnaReference
organism: Mus musculus

MDM 2 s22 sa13 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

P110alpha
type: ProteinReference
xref: P04657
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: P110alpha Synonym: P110-alpha,PIK3CA Accession: P04657
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.P110alpha
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Serine/threonine-protein kinase ppk21
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9Y7J6 141
organism: Schizosaccharomyces pombe

PP2A-C
type: Protein
entity reference: PP2A-C
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot G7MGQ5 264
organism: Macaca mulatta

uniprot P78396 369
type: UnificationXref
id: P78396
db: uniprot

p38 MAPK
type: Protein
entity reference: p38 MAPK
feature: p38 MAPK s28 a79 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: uniprot F1Q2Y3 126
xref: PTHR24356:SF163
organism: Canis lupus familiaris

AKT
type: ProteinReference
xref: P04665
standard name: protein kinase B
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.AKT
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: AKT Synonym: ONCOGENE AKT1,ONCOGENE AKT2,PKB,PKB-ALPHA,PKB-BETA,PROTEIN KINASE B-ALPHA,PROTEIN KINASE B-BETA,RAC SERINE/THREONINE PROTEIN KINASE Accession: P04665 Pathway Link: P00033|P00894|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04641|p53 pathway by glucose deprivation*P00059|P01486|p53 pathway
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: RAC serine/threonine-protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-1

uniprot P20248 366
type: UnificationXref
id: P20248
db: uniprot

Uncharacterized protein
type: DnaReference
organism: Macaca mulatta

uniprot P51945 317
type: UnificationXref
id: P51945
db: uniprot

uniprot F7HSM1 190
type: UnificationXref
id: F7HSM1
db: uniprot

uniprot F7G3I5 150
type: UnificationXref
id: F7G3I5
db: uniprot

uniprot P31750 348
type: UnificationXref
id: P31750
db: uniprot

uniprot P53778 32
type: UnificationXref
id: P53778
db: uniprot

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__P14_19_ARF-RIGHT__p14_p19_ARF-_re111
control type: INHIBITION
controller: p53

Myc
type: ProteinReference
xref: P04649
standard name: v-myc myelocytomatosis viral oncogene homolog
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.Myc
comment: ENTITY_REFERENCE_NOTES= Long Name: Myc Synonym: c-myc Accession: P04649
member entity reference: Signal transducer and activator of transcription 1
member entity reference: Myc proto-oncogene protein
member entity reference: Transcriptional regulator Myc-A
member entity reference: Signal transducer and activator of transcription
member entity reference: Uncharacterized protein

uniprot Q94125 307
type: UnificationXref
id: Q94125
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7H808 189
xref: PTHR45619:SF42
organism: Macaca mulatta

Serine/threonine-protein kinase ksg1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q12701 133
organism: Schizosaccharomyces pombe

Serine-protein kinase ATM
type: ProteinReference
xref: uniprot Q13315 414
xref: PTHR11139:SF72
organism: Homo sapiens

uniprot A0A2I3T6U4 65
type: UnificationXref
id: A0A2I3T6U4
db: uniprot

uniprot Q63789 296
type: UnificationXref
id: Q63789
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re79
controller: SIAH-1

Cyclin-G1
type: ProteinReference
xref: uniprot P51945 317
xref: PTHR10177:SF59
organism: Mus musculus

uniprot Q15759 34
type: UnificationXref
id: Q15759
db: uniprot

Cyclin-A2
type: ProteinReference
xref: uniprot P51943 368
organism: Mus musculus

STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re102
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re102 499
participant stoichiometry: PARTICIPANT STOICHIOMETRY re102 500
left: MDM-2
interaction type: STATE_TRANSITION
right: MDM-2

STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re101
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re101 501
participant stoichiometry: PARTICIPANT STOICHIOMETRY re101 502
left: MDM-2
interaction type: STATE_TRANSITION
right: MDM-2

STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re100
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re100 503
participant stoichiometry: PARTICIPANT STOICHIOMETRY re100 504
left: MDM-2
interaction type: STATE_TRANSITION
right: MDM-2

Cyclin-A2
type: ProteinReference
xref: uniprot F6WZV1 362
organism: Macaca mulatta

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE1 40
organism: Danio rerio

PTEN
type: Protein
entity reference: PTEN
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE2 41
organism: Danio rerio

uniprot E2RKA7 10
type: UnificationXref
id: E2RKA7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6YAB9 17
organism: Monodelphis domestica

PTHR24070:SF420
type: RelationshipXref
id: PTHR24070:SF420
db: PANTHER Family
relationship type: By Homology

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

uniprot W4XW48 111
type: UnificationXref
id: W4XW48
db: uniprot

uniprot E2RLD1 242
type: UnificationXref
id: E2RLD1
db: uniprot

uniprot F6VTR8 252
type: UnificationXref
id: F6VTR8
db: uniprot

PARTICIPANT STOICHIOMETRY re37 517
type: Stoichiometry
physical entity: Complex (MDM-2/Rb)
stoichiometric coefficient: 1.0

S33 p53 s45 a94 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S33
feature location: S33 p53 s45 a94 rs2 S33
comment: MODIFICATION_RESIDUE_ANGLE=2.3412474663214593
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S33

uniprot P31751 349
type: UnificationXref
id: P31751
db: uniprot

PARTICIPANT STOICHIOMETRY re37 515
type: Stoichiometry
physical entity: Rb
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re37 516
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

uniprot O54857 164
type: UnificationXref
id: O54857
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F7DUR2 383
organism: Ornithorhynchus anatinus

eco ECO:0000316 64
type: UnificationXref
id: ECO:0000316
db: eco

S46 p53 s46 a92 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S46
feature location: S46 p53 s46 a92 rs3 S46
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.934482691359872
comment: MODIFICATION_RESIDUE_NAME=S46

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O35904 274
xref: PTHR10048:SF35
organism: Mus musculus

PTHR13844:SF15
type: RelationshipXref
id: PTHR13844:SF15
db: PANTHER Family
relationship type: By Homology

TRANSCRIPTION_LEFT__WIP_1-RIGHT__Wip_1-_re109
type: TemplateReaction
product: Wip-1
xref: TRANSCRIPTION
participant: Wip-1
participant: WIP-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot D3ZTF6 235
organism: Rattus norvegicus

uniprot Q8UUX0 356
type: UnificationXref
id: Q8UUX0
db: uniprot

P21
type: DnaRegionReference
member entity reference: Cyclin-dependent kinase inhibitor 1
member entity reference: Cyclin-dependent kinase inhibitor 1A
member entity reference: Cyclin dependent kinase inhibitor 1A
xref: G04712
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.P21
comment: ENTITY_REFERENCE_NOTES= Long Name: P21 Synonym: p21CIP1,p21WAF1 Accession: G04712

Uncharacterized protein
type: DnaReference
xref: PTHR10177:SF59
organism: Macaca mulatta

uniprot P47196 350
type: UnificationXref
id: P47196
db: uniprot

uniprot A0A2J8QY32 230
type: UnificationXref
id: A0A2J8QY32
db: uniprot

MDM2 proto-oncogene
type: DnaReference
xref: PTHR13844:SF15
organism: Pan troglodytes

Cyclin-G1
type: ProteinReference
xref: uniprot P39950 316
xref: PTHR10177:SF59
organism: Rattus norvegicus

KNOWN_TRANSITION_OMITTED_LEFT__Insulin_IGF_signaling_pathway-RIGHT__PI3K-_re89
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re89 473
participant stoichiometry: PARTICIPANT STOICHIOMETRY re89 474
left: Insulin/IGF signaling pathway
interaction type: KNOWN_TRANSITION_OMITTED
right: PI3K

Ras-like protein
type: ProteinReference
xref: uniprot Q12526 92
xref: PTHR24070:SF17
organism: Emericella nidulans

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

PTHR45976:SF4
type: RelationshipXref
id: PTHR45976:SF4
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase ATR
type: ProteinReference
xref: PTHR11139:SF69
xref: uniprot Q13535 415
organism: Homo sapiens

uniprot F7HLC7 263
type: UnificationXref
id: F7HLC7
db: uniprot

uniprot Q7PMF0 301
type: UnificationXref
id: Q7PMF0
db: uniprot

Complex (MDM-2/Rb)
type: Complex
component stoichiometry: MDM 2 s17 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rb s18 sa7 STOICHIOMETRY ID COMPLEX
component: MDM-2
component: Rb
feature: COMPLEX BINDING FEATURE s26 a69 449
feature: COMPLEX BINDING FEATURE s26 a69 447
cellular location: nucleus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RGI5 361
organism: Macaca mulatta

uniprot F6Z5N3 77
type: UnificationXref
id: F6Z5N3
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

G1/S-specific cyclin-E1
type: ProteinReference
xref: uniprot P39949 326
xref: PTHR10177:SF71
organism: Rattus norvegicus

CCNA2 isoform 1
type: ProteinReference
xref: uniprot H2QQ40 365
organism: Pan troglodytes

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot E2RIF9 241
xref: PTHR10048:SF7
organism: Canis lupus familiaris

PTHR10155:SF3
type: RelationshipXref
id: PTHR10155:SF3
db: PANTHER Family
relationship type: By Homology

PIK3C2A isoform 5
type: ProteinReference
xref: uniprot H2Q383 266
xref: PTHR10048:SF28
organism: Pan troglodytes

AGAP002219-PA
type: ProteinReference
xref: uniprot Q7QK91 99
xref: PTHR24070:SF420
organism: Anopheles gambiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PIP_3-RIGHT__PIP_2-_re82
controller: PTEN

uniprot E7FC99 420
type: UnificationXref
id: E7FC99
db: uniprot

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot D4AA88 379
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q2U4X3 332
xref: PTHR24356:SF171
organism: Gallus gallus

uniprot F1PW15 51
type: UnificationXref
id: F1PW15
db: uniprot

STATE_TRANSITION_LEFT__p14_19_ARF-RIGHT__p14_19_ARF-_re125
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re125 514
participant stoichiometry: PARTICIPANT STOICHIOMETRY re125 513
left: p14/19 ARF
interaction type: STATE_TRANSITION
right: p14/19 ARF

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot F6ZTS0 18
organism: Macaca mulatta

PTHR10155:SF2
type: RelationshipXref
id: PTHR10155:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF1
type: RelationshipXref
id: PTHR10155:SF1
db: PANTHER Family
relationship type: By Homology

Catenin beta-1
type: ProteinReference
xref: uniprot Q02248 428
xref: PTHR45976:SF4
organism: Mus musculus

uniprot Q02099 413
type: UnificationXref
id: Q02099
db: uniprot

uniprot Q6PF93 298
type: UnificationXref
id: Q6PF93
db: uniprot

Cyclin-G1
type: ProteinReference
xref: uniprot P51959 318
organism: Homo sapiens

uniprot P01112 82
type: UnificationXref
id: P01112
db: uniprot

uniprot Q9DGE2 41
type: UnificationXref
id: Q9DGE2
db: uniprot

uniprot F6Z0J4 255
type: UnificationXref
id: F6Z0J4
db: uniprot

PARTICIPANT STOICHIOMETRY re106 492
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re106 491
type: Stoichiometry
physical entity: Complex (p53/MDM-2)
stoichiometric coefficient: 1.0

Cyclin-A2
type: ProteinReference
xref: uniprot P20248 366
organism: Homo sapiens

Cyclin-dependent kinase inhibitor 1
type: DnaReference
organism: Homo sapiens

uniprot Q12701 133
type: UnificationXref
id: Q12701
db: uniprot

Complex (PI3K/P110alpha)
type: Complex
component stoichiometry: PI3K s25 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: P110alpha s29 sa15 STOICHIOMETRY ID COMPLEX
component: PI3K
component: P110alpha
feature: COMPLEX BINDING FEATURE s71 a125 459
feature: COMPLEX BINDING FEATURE s71 a125 461
feature: ACTIVE 46

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A1D5QE27 223
xref: PTHR10048:SF7
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q8UUX0 356
xref: PTHR24356:SF176
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q5F3U4 135
organism: Gallus gallus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 69

uniprot Q06985 218
type: UnificationXref
id: Q06985
db: uniprot

uniprot F1MYJ4 336
type: UnificationXref
id: F1MYJ4
db: uniprot

uniprot W4XEA0 329
type: UnificationXref
id: W4XEA0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot F7EP57 259
organism: Macaca mulatta

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 88

uniprot Q9FLZ5 171
type: UnificationXref
id: Q9FLZ5
db: uniprot

MDM 2 s22 sa13 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.78

PARTICIPANT STOICHIOMETRY re106 493
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

PTHR12081:SF18
type: RelationshipXref
id: PTHR12081:SF18
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription 1
type: ProteinReference
xref: uniprot P42225 58
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q8BTI9 303
organism: Mus musculus

uniprot F1MD46 115
type: UnificationXref
id: F1MD46
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A0G2K5T3 144
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot F6ZM84 256
type: UnificationXref
id: F6ZM84
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__p14_19_ARF-RIGHT__p14_19_ARF-_re125
controller: Ras

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot Q9JJP2 399
organism: Mus musculus

E2F-1
type: ProteinReference
xref: P04652
standard name: E2F transcription factor 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: E2F-1 Synonym: Transcription factor E2F Accession: P04652
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.E2F-1
member entity reference: E2F transcription factor 3
member entity reference: Transcription factor E2f1

Tumor protein 63
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot Q9JJP6 400
organism: Rattus norvegicus

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O08911 23
organism: Mus musculus

uniprot A0A3Q3ACS4 232
type: UnificationXref
id: A0A3Q3ACS4
db: uniprot

uniprot P91634 293
type: UnificationXref
id: P91634
db: uniprot

uniprot H9FVU5 151
type: UnificationXref
id: H9FVU5
db: uniprot

uniprot Q9LT75 172
type: UnificationXref
id: Q9LT75
db: uniprot

uniprot G2HFV8 363
type: UnificationXref
id: G2HFV8
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot F6U7A6 185
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re70 511
type: Stoichiometry
physical entity: DNA damage
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re70 512
type: Stoichiometry
physical entity: ATM
stoichiometric coefficient: 1.0

uniprot D4A3U7 8
type: UnificationXref
id: D4A3U7
db: uniprot

Cyclin-dependent kinase 2
type: ProteinReference
xref: uniprot Q7ZWB1 110
xref: PTHR24056:SF254
organism: Danio rerio

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O08908 273
organism: Mus musculus

Cyclin-G1
type: DnaReference
xref: PTHR10177:SF59
organism: Rattus norvegicus

Seven in absentia homolog 1
type: DnaRegionReference
member entity reference: E3 ubiquitin-protein ligase SIAH1
member entity reference: E3 ubiquitin-protein ligase SIAH1B
member entity reference: E3 ubiquitin-protein ligase SIAH1A
member entity reference: E3 ubiquitin-protein ligase
member entity reference: E3 ubiquitin-protein ligase Siah1
xref: G04711
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.SIAH-1
comment: ENTITY_REFERENCE_NOTES= Long Name: SIAH-1 Synonym: Synonym not specified Accession: G04711
display name: SIAH-1

uniprot F6TD14 250
type: UnificationXref
id: F6TD14
db: uniprot

uniprot E9I1I7 71
type: UnificationXref
id: E9I1I7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot D4A3U7 8
xref: PTHR24055:SF109
organism: Rattus norvegicus

uniprot Q9Z1L0 311
type: UnificationXref
id: Q9Z1L0
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: uniprot F6Z0J4 255
xref: PTHR10155:SF3
organism: Xenopus tropicalis

Mitogen-activated protein kinase p38b
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot O61443 29
organism: Drosophila melanogaster

TRANSCRIPTION_LEFT__MDM_2-RIGHT__MDM_2-_re113
type: TemplateReaction
product: MDM-2
xref: TRANSCRIPTION
participant: MDM-2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot Q567Y8 205
organism: Danio rerio

uniprot P62714 197
type: UnificationXref
id: P62714
db: uniprot

STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re52
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re52 482
participant stoichiometry: PARTICIPANT STOICHIOMETRY re52 481
left: MDM-2
interaction type: STATE_TRANSITION
right: MDM-2

uniprot F6Y841 254
type: UnificationXref
id: F6Y841
db: uniprot

Cyclin-dependent kinase inhibitor 1
type: DnaReference
organism: Macaca mulatta

uniprot Q7ZWB1 110
type: UnificationXref
id: Q7ZWB1
db: uniprot

p53
type: Protein
entity reference: p53
feature: S46 p53 s30 a74 rs3
feature: S33 p53 s30 a74 rs2
feature: p53 s30 a74 rs4
feature: ACTIVE 46
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot D3ZVF3 236
organism: Rattus norvegicus

Cyclin-A1
type: ProteinReference
xref: uniprot Q61456 370
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7GEK1 344
xref: PTHR24356:SF190
organism: Monodelphis domestica

G1/S-specific cyclin-E1
type: ProteinReference
xref: uniprot Q61457 328
xref: PTHR10177:SF71
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_re83
controller: PIP-3

PARTICIPANT STOICHIOMETRY re102 500
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

PP2A-C
type: Protein
entity reference: PP2A-C
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa11 458
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q63789 296
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot Q63788 295
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q9W1M7 310
organism: Drosophila melanogaster

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P32871 152
xref: PTHR10048:SF107
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re100 504
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re100 503
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

PTHR12305:SF81
type: RelationshipXref
id: PTHR12305:SF81
db: PANTHER Family
relationship type: By Homology

Phosphoinositide-3-kinase regulatory subunit 5
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot E2RLD1 242
organism: Canis lupus familiaris

PDK1/2
type: Protein
entity reference: PDK1/2
feature: ACTIVE 46
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot E1BE66 238
organism: Bos taurus

AGAP000018-PA
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q7QEJ7 302
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY re88 476
type: Stoichiometry
physical entity: P110alpha
stoichiometric coefficient: 1.0

uniprot Q61194 294
type: UnificationXref
id: Q61194
db: uniprot

PARTICIPANT STOICHIOMETRY re88 477
type: Stoichiometry
physical entity: Complex (PI3K/P110alpha)
stoichiometric coefficient: 1.0

p21 s7 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p21
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re88 475
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re125 514
type: Stoichiometry
physical entity: p14/19 ARF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re125 513
type: Stoichiometry
physical entity: p14/19 ARF
stoichiometric coefficient: 1.0

uniprot H2QC53 387
type: UnificationXref
id: H2QC53
db: uniprot

a129_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q60823 353
organism: Mus musculus

ATR serine/threonine kinase
type: ProteinReference
xref: PTHR11139:SF69
xref: uniprot F7DU67 407
organism: Xenopus tropicalis

HETERODIMER_ASSOCIATION_LEFT__p21-_Complex__cyclin_E_cdk2_-RIGHT__Complex__cyclin_E_cdk2__p21_-_re31
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 534
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 533
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 532
left: Complex (cyclin E/cdk2)
left: p21
interaction type: HETERODIMER_ASSOCIATION
right: Complex (cyclin E/cdk2/ p21)

ncbitaxon 7165 100
type: UnificationXref
id: 7165
db: ncbitaxon

E3 ubiquitin-protein ligase
type: ProteinReference
xref: PTHR45877:SF1
xref: uniprot F6WEY4 215
organism: Macaca mulatta

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot P32883 89
organism: Mus musculus

uniprot P26450 283
type: UnificationXref
id: P26450
db: uniprot

Cyclin dependent kinase 2
type: ProteinReference
xref: uniprot E2QW70 107
xref: PTHR24056:SF254
organism: Canis lupus familiaris

Complex (cyclin A/cdk2)
type: Complex
component stoichiometry: cyclin A s12 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: cdk2 s13 sa9 STOICHIOMETRY ID COMPLEX
component: cyclin A
component: cdk2
feature: COMPLEX BINDING FEATURE s38 a82 469
feature: COMPLEX BINDING FEATURE s38 a82 467
feature: ACTIVE 46
cellular location: nucleus

PDK1/2
type: Protein
entity reference: PDK1/2
comment: SPECIES_TYPE=PROTEIN

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 181

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: uniprot P22543 280
xref: PTHR10048:SF7
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot E1BMX0 70
organism: Bos taurus

STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 529
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 528
left: MDM-2
interaction type: STATE_TRANSITION
right: MDM-2

STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 525
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 524
left: MDM-2
interaction type: STATE_TRANSITION
right: MDM-2

p53
type: Protein
entity reference: p53
feature: S33 p53 s46 a92 rs2
feature: p53 s46 a92 rs4
feature: ACTIVE 46
feature: S46 p53 s46 a92 rs3
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

E3 ubiquitin-protein ligase
type: DnaReference
xref: PTHR45877:SF1
organism: Macaca mulatta

uniprot F7FDA0 261
type: UnificationXref
id: F7FDA0
db: uniprot

PTHR46778:SF1
type: RelationshipXref
id: PTHR46778:SF1
db: PANTHER Family
relationship type: By Homology

ATM
type: ProteinReference
xref: P04669
standard name: ataxia telangiectasia mutated
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: ATM Synonym: Synonym not specified Accession: P04669
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.ATM
member entity reference: Serine/threonine-protein kinase ATR
member entity reference: Serine-protein kinase ATM
member entity reference: ATR serine/threonine kinase
member entity reference: Uncharacterized protein
member entity reference: UVSB
member entity reference: Serine/threonine-protein kinase tel1
member entity reference: Serine/threonine-protein kinase MEC1
member entity reference: ATR isoform 1
member entity reference: Serine/threonine-protein kinase TEL1
member entity reference: Protein kinase rad3

uniprot D3ZVF3 236
type: UnificationXref
id: D3ZVF3
db: uniprot

MDM 2 s81 a132 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot F1Q3M8 146
type: UnificationXref
id: F1Q3M8
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

uniprot F6QP11 340
type: UnificationXref
id: F6QP11
db: uniprot

Retinoblastoma-like protein 1
type: ProteinReference
xref: uniprot P28749 121
organism: Homo sapiens

uniprot Q7QEJ7 302
type: UnificationXref
id: Q7QEJ7
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9Z1B7 45
organism: Mus musculus

E3 ubiquitin-protein ligase
type: ProteinReference
xref: PTHR45877:SF1
xref: uniprot F1P2G0 214
organism: Gallus gallus

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
organism: Dictyostelium discoideum

PTEN
type: ProteinReference
xref: P04658
standard name: phospatase and tensin homologue
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.PTEN
comment: ENTITY_REFERENCE_NOTES= Long Name: PTEN Synonym: Synonym not specified Accession: P04658
member entity reference: IP16020p
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
member entity reference: MCG118205, isoform CRA_c
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
member entity reference: Putative tyrosine-protein phosphatase TPTE
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A

MDM-2
type: Protein
feature: MDM 2 s4 a59 rs3
feature: MDM 2 s4 a59 rs2
feature: MDM 2 s4 a59 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

p38 MAPK s28 a79 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=2.4149657813309293
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot P38110 411
type: UnificationXref
id: P38110
db: uniprot

PARTICIPANT STOICHIOMETRY re68 520
type: Stoichiometry
physical entity: Ras pathway
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re68 521
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

MDM-2
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa19 446
feature: MDM 2 s59 sa19 rs2
feature: MDM 2 s59 sa19 rs3
feature: MDM 2 s59 sa19 rs1
feature: ACTIVE 46
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot P48463 194
organism: Gallus gallus

E3 ubiquitin-protein ligase SIAH1B
type: ProteinReference
xref: PTHR45877:SF1
xref: uniprot Q06985 218
organism: Mus musculus

uniprot A0A1D5QJY6 224
type: UnificationXref
id: A0A1D5QJY6
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR10177:SF59
organism: Monodelphis domestica

uniprot F6RGI5 361
type: UnificationXref
id: F6RGI5
db: uniprot

uniprot P47197 351
type: UnificationXref
id: P47197
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 14

MDM 2 s81 a132 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5
comment: MODIFICATION_RESIDUE_NAME=

cyclin G
type: ProteinReference
xref: P04662
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: cyclin G Synonym: CCNG,Cyclin G1 Accession: P04662
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.cyclin G
member entity reference: Cyclin-G1
member entity reference: Cyclin G1
member entity reference: Uncharacterized protein
member entity reference: CCNG1 isoform 2

Complex (cyclin E/cdk2)
type: Complex
component stoichiometry: cdk2 s3 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: cyclin E s1 sa1 STOICHIOMETRY ID COMPLEX
component: cdk2
component: cyclin E
feature: COMPLEX BINDING FEATURE s20 a55 463
feature: COMPLEX BINDING FEATURE s20 a55 465
feature: ACTIVE 46
cellular location: nucleus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__P14_19_ARF-RIGHT__p14_p19_ARF-_re111
control type: ACTIVATION
controller: beta-catenin

ncbitaxon 44689 170
type: UnificationXref
id: 44689
db: ncbitaxon

beta catenin s78 a129 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot H2QQ40 365
type: UnificationXref
id: H2QQ40
db: uniprot

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O15530 127
organism: Homo sapiens

CYCLIN G
type: DnaRegion
entity reference: CYCLIN G
cellular location: nucleus
comment: SPECIES_TYPE=GENE

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot Q61411 97
organism: Mus musculus

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P08556 84
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F6QE96 339
organism: Macaca mulatta

uniprot A0A2I3TEU6 320
type: UnificationXref
id: A0A2I3TEU6
db: uniprot

TRANSCRIPTION
type: InteractionVocabulary

p21
type: Protein
entity reference: p21
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7G3I5 150
xref: PTHR10048:SF107
organism: Monodelphis domestica

uniprot P23583 57
type: UnificationXref
id: P23583
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 2
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot H2QFS6 267
organism: Pan troglodytes

Protein Mdm4
type: DnaReference
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F1PRG4 337
organism: Canis lupus familiaris

uniprot E7EXT6 335
type: UnificationXref
id: E7EXT6
db: uniprot

STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_re83
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re83 486
participant stoichiometry: PARTICIPANT STOICHIOMETRY re83 485
left: PDK1/2
interaction type: STATE_TRANSITION
right: PDK1/2

E3 ubiquitin-protein ligase SIAH1
type: DnaReference
xref: PTHR45877:SF1
organism: Rattus norvegicus

uniprot O88898 390
type: UnificationXref
id: O88898
db: uniprot

PTHR10048:SF7
type: RelationshipXref
id: PTHR10048:SF7
db: PANTHER Family
relationship type: By Homology

uniprot Q7KMQ6 168
type: UnificationXref
id: Q7KMQ6
db: uniprot

beta-catenin
type: Protein
entity reference: beta-catenin
feature: beta catenin s78 a129 rs1
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase PKH3
type: ProteinReference
xref: uniprot Q03306 129
organism: Saccharomyces cerevisiae

ncbitaxon 9544 16
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot P04637 392
type: UnificationXref
id: P04637
db: uniprot

MDM 2 s85 a135 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot G3X793 20
xref: PTHR24055:SF109
organism: Bos taurus

Wip1
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q9N272 42
type: UnificationXref
id: Q9N272
db: uniprot

PARTICIPANT STOICHIOMETRY re95 538
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

Protein CBR-LET-60
type: ProteinReference
xref: uniprot A8X0X5 68
xref: PTHR24070:SF420
organism: Caenorhabditis briggsae

uniprot Q6P365 207
type: UnificationXref
id: Q6P365
db: uniprot

PARTICIPANT STOICHIOMETRY re95 539
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

uniprot Q8WYR1 305
type: UnificationXref
id: Q8WYR1
db: uniprot

uniprot F1Q4F8 338
type: UnificationXref
id: F1Q4F8
db: uniprot

ncbitaxon 6669 72
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot Q66JH1 98
type: UnificationXref
id: Q66JH1
db: uniprot

p14/p19 ARF
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

ncbitaxon 9606 26
type: UnificationXref
id: 9606
db: ncbitaxon

ncbitaxon 7668 63
type: UnificationXref
id: 7668
db: ncbitaxon

MDM 2 s17 sa6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.78

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F0ZDJ1 182
xref: PTHR45619:SF12
organism: Dictyostelium purpureum

uniprot F6R8N3 341
type: UnificationXref
id: F6R8N3
db: uniprot

uniprot O70173 277
type: UnificationXref
id: O70173
db: uniprot

uniprot P23727 282
type: UnificationXref
id: P23727
db: uniprot

uniprot F7FN64 384
type: UnificationXref
id: F7FN64
db: uniprot

ncbitaxon 39947 137
type: UnificationXref
id: 39947
db: ncbitaxon

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot P47811 31
organism: Mus musculus

uniprot F1P2G0 214
type: UnificationXref
id: F1P2G0
db: uniprot

uniprot P01111 81
type: UnificationXref
id: P01111
db: uniprot

MDM-2
type: Protein
feature: MDM 2 s81 a132 rs2
feature: MDM 2 s81 a132 rs1
feature: MDM 2 s81 a132 rs3
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q92569 306
organism: Homo sapiens

Cyclin-dependent kinase inhibitor 1
type: ProteinReference
xref: uniprot P39689 375
xref: PTHR46778:SF1
organism: Mus musculus

CCNG1 isoform 2
type: ProteinReference
xref: uniprot H2QRY5 315
organism: Pan troglodytes

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Pan troglodytes

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot O88763 279
xref: PTHR10048:SF7
organism: Rattus norvegicus

uniprot Q04970 91
type: UnificationXref
id: Q04970
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 140

uniprot O08908 273
type: UnificationXref
id: O08908
db: uniprot

uniprot F7DUR2 383
type: UnificationXref
id: F7DUR2
db: uniprot

MDM 2 s9 a38 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5
comment: MODIFICATION_RESIDUE_NAME=

STATE_TRANSITION_LEFT__Complex__p53_MDM_2_-RIGHT__p53-_MDM_2-_re106
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re106 492
participant stoichiometry: PARTICIPANT STOICHIOMETRY re106 493
participant stoichiometry: PARTICIPANT STOICHIOMETRY re106 491
left: Complex (p53/MDM-2)
interaction type: STATE_TRANSITION
right: MDM-2
right: p53

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1NH21 331
xref: PTHR24356:SF176
organism: Bos taurus

MDM 2 s9 a38 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

ATR serine/threonine kinase
type: ProteinReference
xref: uniprot A0A3Q1M8V1 401
xref: PTHR11139:SF69
organism: Bos taurus

MDM 2 s22 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7GAP5 262
organism: Ornithorhynchus anatinus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__CYCLIN_G-RIGHT__CYCLIN_G-_re119
control type: ACTIVATION
controller: p53

MDM 2 s17 sa6 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

TRANSCRIPTION_LEFT__CYCLIN_G-RIGHT__CYCLIN_G-_re119
type: TemplateReaction
product: CYCLIN G
xref: TRANSCRIPTION
participant: CYCLIN G
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Rattus norvegicus

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F7FN64 384
organism: Macaca mulatta

uniprot P79737 90
type: UnificationXref
id: P79737
db: uniprot

Wip-1
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot K7CDC2 346
organism: Pan troglodytes

Cyclin dependent kinase 2
type: ProteinReference
xref: uniprot A0A2I3RR15 106
xref: PTHR24056:SF254
organism: Pan troglodytes

uniprot A0A1D5Q461 222
type: UnificationXref
id: A0A1D5Q461
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot O00750 272
organism: Homo sapiens

uniprot A5D7R9 67
type: UnificationXref
id: A5D7R9
db: uniprot

uniprot Q3T0N5 36
type: UnificationXref
id: Q3T0N5
db: uniprot

TRANSLATION_LEFT__P110ALPHA-RIGHT__P110alpha-_re122
type: TemplateReaction
product: P110alpha
xref: TRANSLATION
participant: P110alpha
participant: P110ALPHA
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Cyclin-dependent kinase 2
type: ProteinReference
xref: uniprot Q5E9Y0 109
xref: PTHR24056:SF254
organism: Bos taurus

cdk2 s3 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cdk2
stoichiometric coefficient: 1.0

RB transcriptional corepressor like 1
type: ProteinReference
xref: uniprot H2QKB0 118
organism: Pan troglodytes

eco ECO:0000353 325
type: UnificationXref
id: ECO:0000353
db: eco

Rb s18 sa7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O00329 269
xref: PTHR10048:SF35
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re32 529
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

uniprot F7F5X1 79
type: UnificationXref
id: F7F5X1
db: uniprot

PTHR24055:SF238
type: RelationshipXref
id: PTHR24055:SF238
db: PANTHER Family
relationship type: By Homology

Danio rerio
type: BioSource
xref: ncbitaxon 7955 28

PARTICIPANT STOICHIOMETRY re32 528
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

uniprot F6W7C8 253
type: UnificationXref
id: F6W7C8
db: uniprot

S33 p53 s30 a74 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S33
feature location: S33 p53 s30 a74 rs2 S33
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3412474663214593
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S33

Serine/threonine-protein kinase PKH2
type: ProteinReference
xref: PTHR24356:SF368
xref: uniprot Q12236 132
organism: Saccharomyces cerevisiae

uniprot P08556 84
type: UnificationXref
id: P08556
db: uniprot

Retinoblastoma-associated protein
type: ProteinReference
xref: uniprot P06400 119
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot A0A3Q3ACS4 232
organism: Gallus gallus

uniprot F7BZL6 258
type: UnificationXref
id: F7BZL6
db: uniprot

MDM 2 s17 sa6 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot Q63538 37
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re81 489
type: Stoichiometry
physical entity: PIP-2
stoichiometric coefficient: 1.0

uniprot F6ZIB3 406
type: UnificationXref
id: F6ZIB3
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P10361 393
organism: Rattus norvegicus

uniprot F1QGH7 421
type: UnificationXref
id: F1QGH7
db: uniprot

uniprot P67939 395
type: UnificationXref
id: P67939
db: uniprot

Tumor protein p73
type: ProteinReference
xref: uniprot O15350 389
xref: PTHR11447:SF21
organism: Homo sapiens

uniprot A0A3Q2U4X3 332
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

uniprot Q8NEB9 304
type: UnificationXref
id: Q8NEB9
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot D4A5Q1 237
xref: PTHR10048:SF35
organism: Rattus norvegicus

IDA
type: EvidenceCodeVocabulary

Ras pathway
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

uniprot F7EP57 259
type: UnificationXref
id: F7EP57
db: uniprot

PARTICIPANT STOICHIOMETRY re81 490
type: Stoichiometry
physical entity: PIP-3
stoichiometric coefficient: 1.0

Complex (cyclin E/cdk2/ p21)
type: Complex
component stoichiometry: p21 s7 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: cdk2 s6 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: cyclin E s5 sa3 STOICHIOMETRY ID COMPLEX
component: cyclin E
component: cdk2
component: p21
feature: COMPLEX BINDING FEATURE s21 a57 437
feature: COMPLEX BINDING FEATURE s21 a57 435
feature: COMPLEX BINDING FEATURE s21 a57 433
cellular location: nucleus

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot P53778 32
xref: PTHR24055:SF146
organism: Homo sapiens

uniprot O88763 279
type: UnificationXref
id: O88763
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A2I3TRY9 228
xref: PTHR10048:SF7
organism: Pan troglodytes

uniprot P61092 217
type: UnificationXref
id: P61092
db: uniprot

uniprot P33568 122
type: UnificationXref
id: P33568
db: uniprot

MDM 2 s9 a38 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.78

uniprot Q0P594 204
type: UnificationXref
id: Q0P594
db: uniprot

PI3K
type: ProteinReference
xref: P04661
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: PI3K Synonym: PI3-K,PI3K,Phosphoinositide 3-OH-kinase,Phosphoinositide 3-kinase Accession: P04661
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.PI3K
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit beta
member entity reference: PIK3R1 isoform 1
member entity reference: Phosphoinositide 3-kinase regulatory subunit 5
member entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Pi3K21B, isoform B
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
member entity reference: AGAP000018-PA
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit gamma
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: Phosphoinositide-3-kinase regulatory subunit 1
member entity reference: PIK3CG isoform 1
member entity reference: LD28067p
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha
member entity reference: Phosphoinositide-3-kinase regulatory subunit 2
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
member entity reference: PIK3C2A isoform 5
member entity reference: PIK3R5 isoform 2
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
member entity reference: Phosphatidylinositol 3-kinase vps34
member entity reference: Phosphatidylinositol 3-kinase VPS34-like
member entity reference: Phosphoinositide-3-kinase regulatory subunit 3
member entity reference: Phosphatidylinositol 3-kinase 1

Catenin (Cadherin-associated protein), beta 1, 88kDa
type: ProteinReference
xref: uniprot Q28GC2 430
xref: PTHR45976:SF4
organism: Xenopus tropicalis

Serine-protein kinase ATM
type: ProteinReference
xref: uniprot D4ACL8 403
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6XP81 343
organism: Xenopus tropicalis

uniprot Q9Z2A0 142
type: UnificationXref
id: Q9Z2A0
db: uniprot

uniprot P18824 426
type: UnificationXref
id: P18824
db: uniprot

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF109
type: RelationshipXref
id: PTHR10048:SF109
db: PANTHER Family
relationship type: By Homology

S46 p53 s45 a94 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S46
feature location: S46 p53 s45 a94 rs3 S46
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.934482691359872
comment: MODIFICATION_RESIDUE_NAME=S46

PARTICIPANT STOICHIOMETRY re53 479
type: Stoichiometry
physical entity: PP2A-C
stoichiometric coefficient: 1.0

uniprot E2RQ78 114
type: UnificationXref
id: E2RQ78
db: uniprot

PARTICIPANT STOICHIOMETRY re53 478
type: Stoichiometry
physical entity: cyclin G
stoichiometric coefficient: 1.0

Cyclin-dependent kinase 2
type: ProteinReference
xref: uniprot P24941 108
xref: PTHR24056:SF254
organism: Homo sapiens

PTHR11139:SF72
type: RelationshipXref
id: PTHR11139:SF72
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38_MAPK-RIGHT__p38_MAPK-_re46
controller: Wip1

Uncharacterized protein
type: ProteinReference
xref: uniprot W4XW48 111
organism: Strongylocentrotus purpuratus

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot A0A2R8Q8S1 66
organism: Danio rerio

ncbitaxon 9031 47
type: UnificationXref
id: 9031
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re105 494
type: Stoichiometry
physical entity: Complex (p53/MDM-2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re105 495
type: Stoichiometry
physical entity: Complex (p53/MDM-2)
stoichiometric coefficient: 1.0

PTHR11139:SF69
type: RelationshipXref
id: PTHR11139:SF69
db: PANTHER Family
relationship type: By Homology

uniprot P01109 55
type: UnificationXref
id: P01109
db: uniprot

uniprot A0A0G2K344 143
type: UnificationXref
id: A0A0G2K344
db: uniprot

uniprot Q92569 306
type: UnificationXref
id: Q92569
db: uniprot

uniprot Q9JJP2 399
type: UnificationXref
id: Q9JJP2
db: uniprot

PTHR24070:SF17
type: RelationshipXref
id: PTHR24070:SF17
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF64
type: RelationshipXref
id: PTHR10048:SF64
db: PANTHER Family
relationship type: By Homology

Catenin beta-1
type: ProteinReference
xref: uniprot P35222 427
xref: PTHR45976:SF4
organism: Homo sapiens

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 9

TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re123
type: TemplateReaction
product: PTEN
xref: TRANSCRIPTION
participant: PTEN
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

G1-S cell cycle arrest
type: Pathway

uniprot A8X0X5 68
type: UnificationXref
id: A8X0X5
db: uniprot

uniprot A0A2I3RR15 106
type: UnificationXref
id: A0A2I3RR15
db: uniprot

PARTICIPANT STOICHIOMETRY re53 480
type: Stoichiometry
physical entity: Complex (cyclin G/PP2A-C)
stoichiometric coefficient: 1.0

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__p14_19_ARF-RIGHT__p14_19_ARF-_re125
controller: Myc

p53
type: Protein
entity reference: p53
feature: p53 s48 sa18 rs4
feature: S46 p53 s48 sa18 rs3
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa18 444
feature: S33 p53 s48 sa18 rs2
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q8RUE8 136
type: UnificationXref
id: Q8RUE8
db: uniprot

Serine/threonine-protein phosphatase PP2A
type: ProteinReference
xref: uniprot P23696 193
xref: PTHR45619:SF12
organism: Drosophila melanogaster

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

PI3K
type: Protein
entity reference: PI3K
comment: SPECIES_TYPE=PROTEIN

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 72

INHIBITION
type: RelationshipTypeVocabulary

MDM 2 s17 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

PTHR11447:SF21
type: RelationshipXref
id: PTHR11447:SF21
db: PANTHER Family
relationship type: By Homology

uniprot P60483 166
type: UnificationXref
id: P60483
db: uniprot

TRANSCRIPTION_LEFT__P110ALPHA-RIGHT__P110ALPHA-_re121
type: TemplateReaction
product: P110ALPHA
xref: TRANSCRIPTION
participant: P110ALPHA
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: uniprot Q61194 294
xref: PTHR10048:SF28
organism: Mus musculus

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot E9QG65 380
organism: Danio rerio

P21
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

GTPase HRas isoform 1
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot F7F5K9 78
organism: Macaca mulatta

p14/19 ARF
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa12 452
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P60484 167
type: UnificationXref
id: P60484
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P02340 391
xref: PTHR11447:SF6
organism: Mus musculus

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: uniprot Q17941 352
xref: PTHR24356:SF333
organism: Caenorhabditis elegans

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

ATR isoform 1
type: ProteinReference
xref: uniprot K7DR10 409
xref: PTHR11139:SF69
organism: Pan troglodytes

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1M8V1 401
type: UnificationXref
id: A0A3Q1M8V1
db: uniprot

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot F1PW15 51
organism: Canis lupus familiaris

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot G5EE01 162
organism: Caenorhabditis elegans

uniprot D4A5Q1 237
type: UnificationXref
id: D4A5Q1
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot F7HLC7 263
organism: Macaca mulatta

STATE_TRANSITION_LEFT__p38_MAPK-RIGHT__p38_MAPK-_re47
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 505
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 506
left: p38 MAPK
interaction type: STATE_TRANSITION
right: p38 MAPK

STATE_TRANSITION_LEFT__p38_MAPK-RIGHT__p38_MAPK-_re46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 510
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 509
left: p38 MAPK
interaction type: STATE_TRANSITION
right: p38 MAPK

uniprot F7C798 19
type: UnificationXref
id: F7C798
db: uniprot

uniprot H2Q7K0 117
type: UnificationXref
id: H2Q7K0
db: uniprot

uniprot A0A2I3TNH3 155
type: UnificationXref
id: A0A2I3TNH3
db: uniprot

LD28067p
type: ProteinReference
xref: uniprot Q7K3H0 299
xref: PTHR10048:SF64
organism: Drosophila melanogaster

Zgc:55558
type: ProteinReference
xref: PTHR24070:SF392
xref: uniprot Q7ZUL8 101
organism: Danio rerio

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot E2RH85 240
organism: Canis lupus familiaris

uniprot F7CKQ1 313
type: UnificationXref
id: F7CKQ1
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A3Q1LQK4 231
xref: PTHR10048:SF7
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot G3X7B5 345
xref: PTHR24351:SF200
organism: Bos taurus

Catenin beta-1
type: ProteinReference
xref: uniprot F1QGH7 421
xref: PTHR45976:SF4
organism: Danio rerio

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 143
xref: PTHR10048:SF107
organism: Rattus norvegicus

KNOWN_TRANSITION_OMITTED_LEFT__DNA_damage-RIGHT__ATM-_re70
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re70 512
participant stoichiometry: PARTICIPANT STOICHIOMETRY re70 511
left: DNA damage
interaction type: KNOWN_TRANSITION_OMITTED
right: ATM

Cyclin G1
type: ProteinReference
xref: uniprot E2RSX2 312
xref: PTHR10177:SF59
organism: Canis lupus familiaris

uniprot Q6GLE6 206
type: UnificationXref
id: Q6GLE6
db: uniprot

PIP-3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O15530 127
type: UnificationXref
id: O15530
db: uniprot

Retinoblastoma-associated protein
type: ProteinReference
xref: uniprot P13405 120
organism: Mus musculus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7CP86 187
xref: PTHR45619:SF44
organism: Monodelphis domestica

PTHR10048:SF48
type: RelationshipXref
id: PTHR10048:SF48
db: PANTHER Family
relationship type: By Homology

MDM 2 s81 a132 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.78

Serine-protein kinase ATM
type: ProteinReference
xref: uniprot F6ZIB3 406
xref: PTHR11139:SF72
organism: Macaca mulatta

uniprot Q5F352 96
type: UnificationXref
id: Q5F352
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot Q8T9S7 169
organism: Dictyostelium discoideum

P110ALPHA
type: DnaRegionReference
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
xref: G04707
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.P110ALPHA
comment: ENTITY_REFERENCE_NOTES= Long Name: P110ALPHA Synonym: P110-alpha,PIK3CA Accession: G04707

uniprot P22981 87
type: UnificationXref
id: P22981
db: uniprot

uniprot F7F5K9 78
type: UnificationXref
id: F7F5K9
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 183

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A8X0Q9 175
organism: Caenorhabditis briggsae

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: uniprot Q503B6 95
xref: PTHR24070:SF423
organism: Danio rerio

uniprot P52160 59
type: UnificationXref
id: P52160
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1Q3M8 146
xref: PTHR10048:SF107
organism: Canis lupus familiaris

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

ncbitaxon 6238 69
type: UnificationXref
id: 6238
db: ncbitaxon

CYCLIN G
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot C3XQF4 180
organism: Branchiostoma floridae

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H9FVU5 151
xref: PTHR10048:SF107
organism: Macaca mulatta

uniprot F1Q2Y3 126
type: UnificationXref
id: F1Q2Y3
db: uniprot

uniprot P54674 290
type: UnificationXref
id: P54674
db: uniprot

MDM-2
type: Protein
feature: MDM 2 s22 sa13 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa13 454
feature: MDM 2 s22 sa13 rs3
feature: MDM 2 s22 sa13 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q9WU82 431
type: UnificationXref
id: Q9WU82
db: uniprot

uniprot P08644 86
type: UnificationXref
id: P08644
db: uniprot

ncbitaxon 559292 130
type: UnificationXref
id: 559292
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re34
controller: Complex (cyclin E/cdk2)

cdk2 s13 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cdk2
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Retinoblastoma-associated protein
type: ProteinReference
xref: uniprot P33568 122
organism: Rattus norvegicus

uniprot P13405 120
type: UnificationXref
id: P13405
db: uniprot

p53 s36 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

uniprot P54675 291
type: UnificationXref
id: P54675
db: uniprot

uniprot O61443 29
type: UnificationXref
id: O61443
db: uniprot

uniprot F6YAB9 17
type: UnificationXref
id: F6YAB9
db: uniprot

PTHR10048:SF29
type: RelationshipXref
id: PTHR10048:SF29
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF28
type: RelationshipXref
id: PTHR10048:SF28
db: PANTHER Family
relationship type: By Homology

uniprot P39950 316
type: UnificationXref
id: P39950
db: uniprot

uniprot O75747 278
type: UnificationXref
id: O75747
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 234
organism: Rattus norvegicus

PTHR10048:SF30
type: RelationshipXref
id: PTHR10048:SF30
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F6Y841 254
organism: Canis lupus familiaris

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 93

Insulin/IGF signaling pathway
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

MDM-2
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa6 448
feature: MDM 2 s17 sa6 rs1
feature: MDM 2 s17 sa6 rs2
feature: MDM 2 s17 sa6 rs3
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q29537 397
type: UnificationXref
id: Q29537
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot H2QNY5 388
xref: PTHR11447:SF8
organism: Pan troglodytes

uniprot F6ZTS0 18
type: UnificationXref
id: F6ZTS0
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: uniprot O70167 276
xref: PTHR10048:SF29
organism: Mus musculus

uniprot F7GA51 385
type: UnificationXref
id: F7GA51
db: uniprot

AKT
type: Protein
entity reference: AKT
feature: AKT s64 a116 rs1
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F6TD14 250
organism: Monodelphis domestica

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot W4ZAK5 212
xref: PTHR45619:SF12
organism: Strongylocentrotus purpuratus

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot P23726 281
organism: Bos taurus

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P23727 282
organism: Bos taurus

uniprot P24941 108
type: UnificationXref
id: P24941
db: uniprot

uniprot Q8BTI9 303
type: UnificationXref
id: Q8BTI9
db: uniprot

uniprot B8XIA5 50
type: UnificationXref
id: B8XIA5
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F1PL57 382
organism: Canis lupus familiaris

CCNE1 isoform 1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot A0A2I3TEU6 320
organism: Pan troglodytes

WIP-1
type: DnaRegion
entity reference: Wildtype p53-induced phosphatase
cellular location: nucleus
comment: SPECIES_TYPE=GENE

uniprot Q9TXI7 309
type: UnificationXref
id: Q9TXI7
db: uniprot

Protein phosphatase 1D
type: DnaReference
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6SW23 147
xref: PTHR10048:SF107
organism: Gallus gallus

beta catenin s51 a101 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot A0A2R8Q8S1 66
type: UnificationXref
id: A0A2R8Q8S1
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70173 277
organism: Rattus norvegicus

phospatase and tensin homologue
type: DnaRegionReference
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
member entity reference: IP16020p
member entity reference: Putative tyrosine-protein phosphatase TPTE
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
member entity reference: MCG118205, isoform CRA_c
xref: G04714
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.PTEN
comment: ENTITY_REFERENCE_NOTES= Long Name: PTEN Synonym: Synonym not specified Accession: G04714
display name: PTEN

Phosphatidylinositol 3-kinase vps34
type: ProteinReference
xref: uniprot P50520 288
xref: PTHR10048:SF7
organism: Schizosaccharomyces pombe

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6RCU6 342
organism: Macaca mulatta

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot F6ZM84 256
organism: Xenopus tropicalis

p53 s36 sa16 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Catenin, beta 2
type: ProteinReference
xref: uniprot E7FC99 420
organism: Danio rerio

E3 ubiquitin-protein ligase SIAH1
type: ProteinReference
xref: PTHR45877:SF1
xref: uniprot Q920M9 221
organism: Rattus norvegicus

uniprot G3X793 20
type: UnificationXref
id: G3X793
db: uniprot

uniprot Q63538 37
type: UnificationXref
id: Q63538
db: uniprot

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9WUI1 44
xref: PTHR24055:SF109
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PIP_2-RIGHT__PIP_3-_re81
controller: Complex (PI3K/P110alpha)

uniprot F6WZV1 362
type: UnificationXref
id: F6WZV1
db: uniprot

SIAH-1
type: Protein
entity reference: SIAH-1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Catenin beta 1
type: ProteinReference
xref: uniprot F6WBD5 423
xref: PTHR45976:SF4
organism: Ornithorhynchus anatinus

uniprot A0A1D5Q1X3 105
type: UnificationXref
id: A0A1D5Q1X3
db: uniprot

Complex (p14/19 ARF/ MDM-2)
type: Complex
component stoichiometry: p14 19 ARF s19 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: MDM 2 s22 sa13 STOICHIOMETRY ID COMPLEX
component: MDM-2
component: p14/19 ARF
feature: COMPLEX BINDING FEATURE s49 a99 453
feature: COMPLEX BINDING FEATURE s49 a99 451
cellular location: nucleus

Mouse double minute 2
type: DnaRegionReference
member entity reference: Protein Mdm4
member entity reference: E3 ubiquitin-protein ligase Mdm2
member entity reference: MDM2 proto-oncogene
xref: G04709
comment: ENTITY_REFERENCE_NOTES= Long Name: MDM-2 Synonym: Synonym not specified Accession: G04709
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.MDM-2
display name: MDM-2

Cyclin-dependent kinase inhibitor 1
type: ProteinReference
xref: uniprot P38936 374
organism: Homo sapiens

p53 s46 a92 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot B0S576 378
organism: Danio rerio

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q9XF67 139
xref: PTHR24356:SF163
organism: Arabidopsis thaliana

uniprot Q9XZE5 211
type: UnificationXref
id: Q9XZE5
db: uniprot

ncbitaxon 284812 134
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q2HJ27 60
type: UnificationXref
id: Q2HJ27
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42336 153
xref: PTHR10048:SF107
organism: Homo sapiens

uniprot A0NBA9 233
type: UnificationXref
id: A0NBA9
db: uniprot

STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re79
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re79 508
participant stoichiometry: PARTICIPANT STOICHIOMETRY re79 507
left: beta-catenin
interaction type: STATE_TRANSITION
right: beta-catenin

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 130

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot P42338 285
organism: Homo sapiens

uniprot Q5E9I1 319
type: UnificationXref
id: Q5E9I1
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42337 154
xref: PTHR10048:SF107
organism: Mus musculus

Phosphatidylinositol 3-kinase age-1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q94125 307
organism: Caenorhabditis elegans

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 30

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot P42339 286
organism: Arabidopsis thaliana

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Xenopus tropicalis

TRANSLATION_LEFT__p14_p19_ARF-RIGHT__p14_19_ARF-_re112
type: TemplateReaction
product: p14/19 ARF
xref: TRANSLATION
participant: p14/p19 ARF
participant: p14/19 ARF
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot Q13535 415
type: UnificationXref
id: Q13535
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Pan troglodytes

uniprot Q13315 414
type: UnificationXref
id: Q13315
db: uniprot

uniprot F1MKA9 381
type: UnificationXref
id: F1MKA9
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q6PF93 298
xref: PTHR10048:SF7
organism: Mus musculus

cyclin G
type: Protein
entity reference: cyclin G
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa10 456
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot H2PXY8 265
type: UnificationXref
id: H2PXY8
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__cyclin_G-_PP2A_C-RIGHT__Complex__cyclin_G_PP2A_C_-_re53
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re53 478
participant stoichiometry: PARTICIPANT STOICHIOMETRY re53 480
participant stoichiometry: PARTICIPANT STOICHIOMETRY re53 479
left: PP2A-C
left: cyclin G
interaction type: HETERODIMER_ASSOCIATION
right: Complex (cyclin G/PP2A-C)

PARTICIPANT STOICHIOMETRY re57 471
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY re82 488
type: Stoichiometry
physical entity: PIP-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re82 487
type: Stoichiometry
physical entity: PIP-3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re57 472
type: Stoichiometry
physical entity: a94_degraded
stoichiometric coefficient: 1.0

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q95ME4 102
organism: Monodelphis domestica

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
type: ProteinReference
xref: uniprot Q9LT75 172
organism: Arabidopsis thaliana

uniprot O74630 410
type: UnificationXref
id: O74630
db: uniprot

TRANSLATION_LEFT__PTEN-RIGHT__PTEN-_re124
type: TemplateReaction
product: PTEN
xref: TRANSLATION
participant: PTEN
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot F6QM53 248
type: UnificationXref
id: F6QM53
db: uniprot

eco ECO:0000303 322
type: UnificationXref
id: ECO:0000303
db: eco

Protein Mdm4
type: DnaReference
organism: Canis lupus familiaris

uniprot F7DU67 407
type: UnificationXref
id: F7DU67
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot P63331 201
organism: Rattus norvegicus

E3 ubiquitin-protein ligase SIAH1A
type: ProteinReference
xref: PTHR45877:SF1
xref: uniprot P61092 217
organism: Mus musculus

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot F6W7C8 253
organism: Macaca mulatta

uniprot P50520 288
type: UnificationXref
id: P50520
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot P63330 200
organism: Mus musculus

P110alpha
type: Protein
entity reference: P110alpha
comment: SPECIES_TYPE=PROTEIN

uniprot P62715 198
type: UnificationXref
id: P62715
db: uniprot

uniprot Q16539 35
type: UnificationXref
id: Q16539
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
type: DnaReference
name: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
organism: Arabidopsis thaliana

PDK1/2
type: ProteinReference
xref: P04656
standard name: 3-phosphoinositide-dependent protein kinase 1 and 2
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.PDK1/2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: PDK1/2 Synonym: Synonym not specified Accession: P04656
member entity reference: 3-phosphoinositide-dependent protein kinase 1
member entity reference: 3-phosphoinositide dependent protein kinase 1
member entity reference: Serine/threonine-protein kinase ksg1
member entity reference: Serine/threonine-protein kinase ppk21
member entity reference: Serine/threonine-protein kinase PKH3
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase PKH2
member entity reference: Serine/threonine-protein kinase PKH1
member entity reference: Os01g0872800 protein

E3 ubiquitin-protein ligase
type: DnaReference
xref: PTHR45877:SF1
organism: Bos taurus

TRANSLATION
type: RelationshipTypeVocabulary

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Homo sapiens

G1/S-specific cyclin-E1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot F1NQ71 321
organism: Gallus gallus

uniprot E2RPB0 243
type: UnificationXref
id: E2RPB0
db: uniprot

uniprot H2QFS6 267
type: UnificationXref
id: H2QFS6
db: uniprot

uniprot P39689 375
type: UnificationXref
id: P39689
db: uniprot

RB transcriptional corepressor 1
type: ProteinReference
xref: uniprot F1PQ32 116
organism: Canis lupus familiaris

uniprot P56180 165
type: UnificationXref
id: P56180
db: uniprot

p53 s45 a94 rs4
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot F7BBM1 257
organism: Monodelphis domestica

cdk2
type: Protein
entity reference: cdk2
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa9 470
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 48

uniprot F7CP86 187
type: UnificationXref
id: F7CP86
db: uniprot

PTHR45851:SF1
type: RelationshipXref
id: PTHR45851:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F6VXG1 148
type: UnificationXref
id: F6VXG1
db: uniprot

ncbitaxon 367110 196
type: UnificationXref
id: 367110
db: ncbitaxon

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Danio rerio

Ppm1d protein
type: DnaReference
organism: Rattus norvegicus

uniprot F1Q2Q9 247
type: UnificationXref
id: F1Q2Q9
db: uniprot

uniprot Q9Y7J6 141
type: UnificationXref
id: Q9Y7J6
db: uniprot

uniprot G7MGQ5 264
type: UnificationXref
id: G7MGQ5
db: uniprot

uniprot Q28EW2 94
type: UnificationXref
id: Q28EW2
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot E7FC59 157
organism: Danio rerio

Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot Q66JH1 98
organism: Xenopus tropicalis

uniprot O15264 25
type: UnificationXref
id: O15264
db: uniprot

TRANSLATION_LEFT__CYCLIN_G-RIGHT__cyclin_G-_re120
type: TemplateReaction
product: cyclin G
xref: TRANSLATION
participant: cyclin G
participant: CYCLIN G
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
name: Uncharacterized protein
xref: PTHR12305:SF81
organism: Canis lupus familiaris

AGAP011036-PA (Fragment)
type: ProteinReference
xref: uniprot A0NBA9 233
xref: PTHR10048:SF64
organism: Anopheles gambiae

cdk2 s6 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cdk2
stoichiometric coefficient: 1.0

uniprot F6V332 15
type: UnificationXref
id: F6V332
db: uniprot

Serine-protein kinase ATM
type: ProteinReference
xref: uniprot E1BEI6 404
xref: PTHR11139:SF72
organism: Bos taurus

uniprot F6WBD5 423
type: UnificationXref
id: F6WBD5
db: uniprot

uniprot Q9DGE1 40
type: UnificationXref
id: Q9DGE1
db: uniprot

Retinoblastoma-associated protein
type: ProteinReference
xref: uniprot Q90600 124
organism: Gallus gallus

MDM 2 s14 a60 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.78

Cyclin G1
type: DnaReference
xref: PTHR10177:SF59
organism: Canis lupus familiaris

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6VAQ8 251
xref: PTHR10048:SF7
organism: Ornithorhynchus anatinus

AKT s65 a117 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

ncbitaxon 7739 181
type: UnificationXref
id: 7739
db: ncbitaxon

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A2I3T7A8 145
organism: Pan troglodytes

E3 ubiquitin-protein ligase Siah1
type: ProteinReference
xref: PTHR45877:SF1
xref: uniprot Q7ZVG6 219
organism: Danio rerio

Cyclin-dependent kinase inhibitor 1
type: ProteinReference
xref: uniprot F7EEK4 372
organism: Macaca mulatta

uniprot Q7KTZ2 300
type: UnificationXref
id: Q7KTZ2
db: uniprot

uniprot Q9HFQ2 210
type: UnificationXref
id: Q9HFQ2
db: uniprot

uniprot O00329 269
type: UnificationXref
id: O00329
db: uniprot

uniprot P79734 396
type: UnificationXref
id: P79734
db: uniprot

uniprot P56424 394
type: UnificationXref
id: P56424
db: uniprot

E3 ubiquitin-protein ligase
type: DnaReference
xref: PTHR45877:SF1
organism: Pan troglodytes

uniprot F7BBM1 257
type: UnificationXref
id: F7BBM1
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7E5M4 188
xref: PTHR45619:SF44
organism: Ornithorhynchus anatinus

uniprot O46404 275
type: UnificationXref
id: O46404
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Gallus gallus

uniprot H2QNG6 268
type: UnificationXref
id: H2QNG6
db: uniprot

uniprot Q02248 428
type: UnificationXref
id: Q02248
db: uniprot

MDM-2
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

p53
type: ProteinReference
xref: P04668
standard name: Tumor protein p53
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.p53
comment: ENTITY_REFERENCE_NOTES= Long Name: p53 Synonym: Synonym not specified Accession: P04668 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04392|P04539|P53 pathway feedback loops 1*P00059|P01485|p53 pathway
member entity reference: Tumor protein 63
member entity reference: Tumor protein p73
member entity reference: Tumor protein 63 (p63)
member entity reference: Cellular tumor antigen p53

ncbitaxon 7955 28
type: UnificationXref
id: 7955
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VBA7 160
xref: PTHR12305:SF81
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re96 530
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re96 531
type: Stoichiometry
physical entity: a129_degraded
stoichiometric coefficient: 1.0

E3 ubiquitin-protein ligase SIAH1
type: ProteinReference
xref: PTHR45877:SF1
xref: uniprot Q8IUQ4 220
organism: Homo sapiens

cdk2
type: ProteinReference
xref: P04653
standard name: Cyclin-dependent kinase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.cdk2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cyclin dependent kinase 2
member entity reference: Uncharacterized protein
member entity reference: Cyclin-dependent kinase 2

uniprot Q9VXG8 418
type: UnificationXref
id: Q9VXG8
db: uniprot

ncbitaxon 9598 39
type: UnificationXref
id: 9598
db: ncbitaxon

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot Q2HJ27 60
organism: Bos taurus

Protein phosphatase 1D
type: DnaReference
organism: Homo sapiens

G1/S-specific cyclin-E1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot P47794 327
organism: Danio rerio

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9Y243 358
xref: PTHR24356:SF190
organism: Homo sapiens

uniprot H2QRY5 315
type: UnificationXref
id: H2QRY5
db: uniprot

Cyclin-dependent kinase inhibitor 1
type: DnaReference
xref: PTHR46778:SF1
organism: Mus musculus

uniprot B0S576 378
type: UnificationXref
id: B0S576
db: uniprot

P110alpha
type: Protein
entity reference: P110alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa15 462
comment: SPECIES_TYPE=PROTEIN

PIK3R1 isoform 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot A0A2I3SIY1 227
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rb-RIGHT__Rb-_re35
controller: Complex (cyclin E/cdk2)

HETERODIMER_ASSOCIATION_LEFT__Rb-_MDM_2-RIGHT__Complex__MDM_2_Rb_-_re37
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 516
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 517
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 515
left: Rb
left: MDM-2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (MDM-2/Rb)

G04709
type: UnificationXref
id: G04709
db: PANTHER Pathway Component

uniprot P10361 393
type: UnificationXref
id: P10361
db: uniprot

G04708
type: UnificationXref
id: G04708
db: PANTHER Pathway Component

Cyclin A2
type: ProteinReference
xref: uniprot G3V802 364
organism: Rattus norvegicus

MDM 2 s85 a135 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

beta-catenin
type: ProteinReference
xref: P04670
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.beta-catenin
comment: ENTITY_REFERENCE_NOTES= Long Name: beta-catenin Synonym: CADHERIN-ASSOCIATED PROTEIN, BETA,CATENIN, BETA-1,CTNNB,CTNNB1 Accession: P04670
member entity reference: Catenin beta-1
member entity reference: Catenin (Cadherin-associated protein), beta 1, 88kDa
member entity reference: Uncharacterized protein
member entity reference: Armadillo segment polarity protein
member entity reference: Catenin, beta 2
member entity reference: Catenin beta 1
member entity reference: CTNNB1 isoform 2

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SFG7 75
xref: PTHR24070:SF388
organism: Macaca mulatta

ncbitaxon 3702 140
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot P63330 200
type: UnificationXref
id: P63330
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7FDA0 261
organism: Monodelphis domestica

uniprot F6SRK5 422
type: UnificationXref
id: F6SRK5
db: uniprot

DNA damage
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MD46 115
organism: Bos taurus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q7PMF0 301
xref: PTHR10048:SF7
organism: Anopheles gambiae

uniprot W4Y0D3 432
type: UnificationXref
id: W4Y0D3
db: uniprot

pro-apoptotic genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

IP16020p
type: DnaReference
xref: PTHR12305:SF81
organism: Drosophila melanogaster

MDM 2 s14 a60 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5
comment: MODIFICATION_RESIDUE_NAME=

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_re84
controller: PDK1/2

G04707
type: UnificationXref
id: G04707
db: PANTHER Pathway Component

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 349
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y0D3 432
organism: Strongylocentrotus purpuratus

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 348
organism: Mus musculus

Putative tyrosine-protein phosphatase TPTE
type: ProteinReference
xref: uniprot P56180 165
organism: Homo sapiens

TRANSLATION_LEFT__P21-RIGHT__p21-_re118
type: TemplateReaction
product: p21
xref: TRANSLATION
participant: p21
participant: P21
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PP2A-C
type: ProteinReference
xref: P04659
standard name: Protein phosphatase 2 catalytic subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.PP2A-C
comment: ENTITY_REFERENCE_NOTES= Long Name: PP2A-C Synonym: Synonym not specified Accession: P04659
member entity reference: Serine/threonine-protein phosphatase
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit A
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
member entity reference: Serine/threonine-protein phosphatase PP2A catalytic subunit
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit
member entity reference: Serine/threonine-protein phosphatase PP2A

cyclin A
type: ProteinReference
xref: P04666
standard name: Cyclin A
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.cyclin A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Cyclin-A1
member entity reference: Cyclin-A2
member entity reference: Cyclin A2
member entity reference: CCNA2 isoform 1
member entity reference: CCNA1 isoform 3

Bos taurus
type: BioSource
xref: ncbitaxon 9913 4

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9WUA6 357
xref: PTHR24356:SF190
organism: Mus musculus

HETERODIMER_ASSOCIATION_LEFT__p14_19_ARF-_MDM_2-RIGHT__Complex__p14_19_ARF__MDM_2_-_re63
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 536
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 537
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 535
left: p14/19 ARF
left: MDM-2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (p14/19 ARF/ MDM-2)

MDM 2 s85 a135 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.78

PARTICIPANT STOICHIOMETRY re34 525
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__P14_19_ARF-RIGHT__p14_p19_ARF-_re111
type: TemplateReaction
product: p14/p19 ARF
xref: TRANSCRIPTION
participant: P14/19 ARF
participant: p14/p19 ARF
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

TRANSLATION
type: InteractionVocabulary

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 49

uniprot P48580 195
type: UnificationXref
id: P48580
db: uniprot

uniprot Q5F3U4 135
type: UnificationXref
id: Q5F3U4
db: uniprot

PARTICIPANT STOICHIOMETRY re34 524
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

P14/19 ARF
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Putative tyrosine-protein phosphatase TPTE
type: DnaReference
organism: Homo sapiens

Ras
type: ProteinReference
xref: P04651
standard name: V-HA-RAS HARVEY RAT SARCOMA VIRAL ONCOGENE HOMOLOG HRAS
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.Ras
comment: ENTITY_REFERENCE_NOTES= Long Name: V-HA-RAS HARVEY RAT SARCOMA VIRAL ONCOGENE HOMOLOG HRAS Synonym: HRAS1 Accession: P04651
member entity reference: GTPase NRas
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: Uncharacterized protein
member entity reference: GTPase HRas
member entity reference: Ras-like protein
member entity reference: Zgc:55558
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: GTPase KRas
member entity reference: Protein CBR-LET-60
member entity reference: NRAS isoform 1
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: KRAS isoform 4
member entity reference: Neuroblastoma RAS viral (v-ras) oncogene homolog
member entity reference: NRAS protein
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: Kirsten rat sarcoma viral oncogene homolog
member entity reference: Ras protein let-60
member entity reference: GTPase HRas isoform 1
member entity reference: AGAP002219-PA

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot P62715 198
organism: Mus musculus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62716 199
xref: PTHR45619:SF44
organism: Rattus norvegicus

uniprot O70167 276
type: UnificationXref
id: O70167
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31749 347
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62714 197
xref: PTHR45619:SF44
organism: Homo sapiens

MDM 2 s14 a60 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q9W0V1 138
xref: PTHR24356:SF163
organism: Drosophila melanogaster

uniprot O02812 21
type: UnificationXref
id: O02812
db: uniprot

uniprot F7BEI4 323
type: UnificationXref
id: F7BEI4
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
type: ProteinReference
xref: uniprot Q9FLZ5 171
organism: Arabidopsis thaliana

uniprot A0A2I3SIY1 227
type: UnificationXref
id: A0A2I3SIY1
db: uniprot

uniprot F6TXC2 13
type: UnificationXref
id: F6TXC2
db: uniprot

uniprot A0A0G2K5T3 144
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: G1-S cell cycle arrest
controller: Complex (cyclin E/cdk2/ p21)

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot B1H2U0 156
xref: PTHR12305:SF81
organism: Xenopus tropicalis

CTNNB1 isoform 2
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot H2R2U1 425
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot B1WB72 333
organism: Xenopus tropicalis

P110ALPHA
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re79 507
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re79 508
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 179

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: uniprot O75747 278
organism: Homo sapiens

Cyclin dependent kinase inhibitor 1A
type: ProteinReference
xref: PTHR46778:SF1
xref: uniprot H2RFJ9 373
organism: Pan troglodytes

uniprot G3X7B5 345
type: UnificationXref
id: G3X7B5
db: uniprot

cyclin E s5 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cyclin E
stoichiometric coefficient: 1.0

CYCLIN G
type: DnaRegionReference
member entity reference: CCNG1 isoform 2
member entity reference: Uncharacterized protein
member entity reference: Cyclin-G1
member entity reference: Cyclin G1
xref: G04715
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.CYCLIN G
comment: ENTITY_REFERENCE_NOTES= Long Name: CYCLIN G Synonym: CCNG,Cyclin G1 Accession: G04715

p53
type: Protein
entity reference: p53
feature: p53 s45 a94 rs4
feature: S46 p53 s45 a94 rs3
feature: S33 p53 s45 a94 rs2
comment: SPECIES_TYPE=PROTEIN

uniprot O42376 27
type: UnificationXref
id: O42376
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4XIE2 62
organism: Strongylocentrotus purpuratus

uniprot Q28GC2 430
type: UnificationXref
id: Q28GC2
db: uniprot

uniprot Q7QK56 354
type: UnificationXref
id: Q7QK56
db: uniprot

PARTICIPANT STOICHIOMETRY re101 502
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot F6SRK5 422
organism: Monodelphis domestica

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 11

PARTICIPANT STOICHIOMETRY re101 501
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot F6QM53 248
organism: Ornithorhynchus anatinus

uniprot Q95NE7 38
type: UnificationXref
id: Q95NE7
db: uniprot

p53
type: Protein
entity reference: p53
feature: S33 p53 s36 sa16 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa16 440
feature: p53 s36 sa16 rs4
feature: S46 p53 s36 sa16 rs3
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Rattus norvegicus

RAC serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q8INB9 355
organism: Drosophila melanogaster

uniprot F1N5G3 213
type: UnificationXref
id: F1N5G3
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re123
control type: ACTIVATION
controller: p53

uniprot Q0VCX4 429
type: UnificationXref
id: Q0VCX4
db: uniprot

uniprot A0A2I3RH39 225
type: UnificationXref
id: A0A2I3RH39
db: uniprot

E2F-1
type: Protein
entity reference: E2F-1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BMR3 113
organism: Bos taurus

uniprot Q7K3H0 299
type: UnificationXref
id: Q7K3H0
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
type: DnaReference
xref: PTHR12305:SF81
organism: Caenorhabditis elegans

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 47

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot Q6GLE6 206
organism: Xenopus tropicalis

E3 ubiquitin-protein ligase
type: ProteinReference
xref: uniprot F1N5G3 213
xref: PTHR45877:SF1
organism: Bos taurus

S33 p53 s36 sa16 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S33
feature location: S33 p53 s36 sa16 rs2 S33
comment: MODIFICATION_RESIDUE_ANGLE=2.3412474663214593
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S33

cyclin A s12 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cyclin A
stoichiometric coefficient: 1.0

uniprot K7DR10 409
type: UnificationXref
id: K7DR10
db: uniprot

uniprot E9QG65 380
type: UnificationXref
id: E9QG65
db: uniprot

uniprot P30274 367
type: UnificationXref
id: P30274
db: uniprot

uniprot P01108 54
type: UnificationXref
id: P01108
db: uniprot

STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re95
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re95 538
participant stoichiometry: PARTICIPANT STOICHIOMETRY re95 539
left: beta-catenin
interaction type: STATE_TRANSITION
right: beta-catenin

TRANSCRIPTION_LEFT__P21-RIGHT__P21-_re117
type: TemplateReaction
product: P21
xref: TRANSCRIPTION
participant: P21
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Transcription factor E2f1
type: ProteinReference
xref: uniprot Q27368 104
xref: PTHR12081:SF18
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F7F5X1 79
organism: Monodelphis domestica

uniprot P63331 201
type: UnificationXref
id: P63331
db: uniprot

uniprot O00750 272
type: UnificationXref
id: O00750
db: uniprot

uniprot D3ZS28 112
type: UnificationXref
id: D3ZS28
db: uniprot

p14/19 ARF
type: Protein
feature: ACTIVE 46
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F6WDS0 76
type: UnificationXref
id: F6WDS0
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6X958 186
xref: PTHR45619:SF44
organism: Canis lupus familiaris

PTHR15593:SF2
type: RelationshipXref
id: PTHR15593:SF2
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re61
controller: p38 MAPK

beta catenin s58 a109 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Armadillo segment polarity protein
type: ProteinReference
xref: uniprot P18824 426
organism: Drosophila melanogaster

Protein Mdm4
type: DnaReference
organism: Rattus norvegicus

PIK3R5 isoform 2
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot A0A2J8MGP0 229
organism: Pan troglodytes

uniprot E1BE66 238
type: UnificationXref
id: E1BE66
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__pro_apoptotic_genes-RIGHT__pro_apoptotic_genes-_re116
control type: ACTIVATION
controller: p53

uniprot O35904 274
type: UnificationXref
id: O35904
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot E2RCV1 239
xref: PTHR10048:SF34
organism: Canis lupus familiaris

PPM1D isoform 1
type: DnaReference
organism: Pan troglodytes

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot A0A2I3TNH3 155
organism: Pan troglodytes

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q5F352 96
organism: Gallus gallus

uniprot Q17941 352
type: UnificationXref
id: Q17941
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P70618 33
xref: PTHR24055:SF110
organism: Rattus norvegicus

uniprot P42337 154
type: UnificationXref
id: P42337
db: uniprot

uniprot F1NT98 159
type: UnificationXref
id: F1NT98
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot Q9JHG7 308
organism: Mus musculus

MDM-2
type: Protein
feature: MDM 2 s9 a38 rs1
feature: MDM 2 s9 a38 rs2
feature: MDM 2 s9 a38 rs3
feature: ACTIVE 46
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot Q0P594 204
organism: Bos taurus

Cyclin-A1
type: ProteinReference
xref: uniprot Q6AY13 371
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6R8N3 341
xref: PTHR24356:SF190
organism: Macaca mulatta

p38 MAPK s35 a71 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4149657813309293
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6VXG1 148
xref: PTHR10048:SF107
organism: Xenopus tropicalis

E3 ubiquitin-protein ligase
type: DnaReference
xref: PTHR45877:SF1
organism: Gallus gallus

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot F7GA51 385
organism: Macaca mulatta

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P47196 350
organism: Rattus norvegicus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P47197 351
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot W4XEA0 329
xref: PTHR10177:SF344
organism: Strongylocentrotus purpuratus

Neuroblastoma RAS viral (v-ras) oncogene homolog
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot F6WDS0 76
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q461 222
organism: Macaca mulatta

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q9TXI7 309
xref: PTHR10048:SF7
organism: Caenorhabditis elegans

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot Q803G3 209
organism: Danio rerio

uniprot F1QNG4 74
type: UnificationXref
id: F1QNG4
db: uniprot

G04714
type: UnificationXref
id: G04714
db: PANTHER Pathway Component

G04712
type: UnificationXref
id: G04712
db: PANTHER Pathway Component

G04711
type: UnificationXref
id: G04711
db: PANTHER Pathway Component

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 137

uniprot P32871 152
type: UnificationXref
id: P32871
db: uniprot

G04715
type: UnificationXref
id: G04715
db: PANTHER Pathway Component

uniprot F7EEK4 372
type: UnificationXref
id: F7EEK4
db: uniprot

uniprot G5E8H5 161
type: UnificationXref
id: G5E8H5
db: uniprot

uniprot F1PL57 382
type: UnificationXref
id: F1PL57
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q6P943 61
organism: Danio rerio

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot B8XIA5 50
organism: Macaca mulatta

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot P01116 83
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HT00 408
xref: PTHR11139:SF69
organism: Macaca mulatta

uniprot F6QE96 339
type: UnificationXref
id: F6QE96
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P01111 81
organism: Homo sapiens

Protein Mdm4
type: DnaReference
organism: Pan troglodytes

GTPase HRas
type: ProteinReference
xref: uniprot P01112 82
xref: PTHR24070:SF385
organism: Homo sapiens

uniprot A0A3Q1NH21 331
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

PARTICIPANT STOICHIOMETRY re102 499
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

PTHR24070:SF392
type: RelationshipXref
id: PTHR24070:SF392
db: PANTHER Family
relationship type: By Homology

Transcriptional regulator Myc-A
type: ProteinReference
xref: uniprot P52160 59
xref: PTHR45851:SF1
organism: Danio rerio

STATE_TRANSITION_LEFT__PIP_2-RIGHT__PIP_3-_re81
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re81 489
participant stoichiometry: PARTICIPANT STOICHIOMETRY re81 490
left: PIP-2
interaction type: STATE_TRANSITION
right: PIP-3

uniprot H2Q383 266
type: UnificationXref
id: H2Q383
db: uniprot

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

MDM 2 s59 sa19 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Serine/threonine-protein phosphatase 2A catalytic subunit A
type: ProteinReference
xref: uniprot Q9XZE5 211
xref: PTHR45619:SF12
organism: Dictyostelium discoideum

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot A0A3Q1LJZ7 3
xref: PTHR24055:SF146
organism: Bos taurus

uniprot F7GAP5 262
type: UnificationXref
id: F7GAP5
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Homo sapiens

uniprot F6WEY4 215
type: UnificationXref
id: F6WEY4
db: uniprot

uniprot E1BMR3 113
type: UnificationXref
id: E1BMR3
db: uniprot

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

a94_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

uniprot E2RJX4 334
type: UnificationXref
id: E2RJX4
db: uniprot

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 100

uniprot A7T2Q5 173
type: UnificationXref
id: A7T2Q5
db: uniprot

pro-apoptotic genes
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

PTHR11447:SF8
type: RelationshipXref
id: PTHR11447:SF8
db: PANTHER Family
relationship type: By Homology

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P01108 54
xref: PTHR45851:SF1
organism: Mus musculus

Serine/threonine-protein phosphatase 2A catalytic subunit
type: ProteinReference
xref: uniprot G5EGK8 191
organism: Caenorhabditis elegans

ncbitaxon 10116 9
type: UnificationXref
id: 10116
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7F3S0 260
organism: Macaca mulatta

PTHR11447:SF6
type: RelationshipXref
id: PTHR11447:SF6
db: PANTHER Family
relationship type: By Homology

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F6Z5N3 77
organism: Monodelphis domestica

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot P01109 55
organism: Gallus gallus

beta-catenin
type: Protein
entity reference: beta-catenin
feature: beta catenin s51 a101 rs1
feature: ACTIVE 46
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P01106 53
xref: PTHR45851:SF1
organism: Homo sapiens

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot A0A167VDT2 377
organism: Gallus gallus

uniprot Q7QK91 99
type: UnificationXref
id: Q7QK91
db: uniprot

ncbitaxon 6945 179
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot F1PRG4 337
type: UnificationXref
id: F1PRG4
db: uniprot

uniprot P42225 58
type: UnificationXref
id: P42225
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot E2RSB0 12
organism: Canis lupus familiaris

Cyclin-G1
type: DnaReference
xref: PTHR10177:SF59
organism: Mus musculus

E3 ubiquitin-protein ligase Siah1
type: DnaReference
xref: PTHR45877:SF1
organism: Danio rerio

PTHR45877:SF1
type: RelationshipXref
id: PTHR45877:SF1
db: PANTHER Family
relationship type: By Homology

MDM 2 s59 sa19 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.78

MDM-2
type: Protein
feature: MDM 2 s85 a135 rs2
feature: MDM 2 s85 a135 rs3
feature: MDM 2 s85 a135 rs1
feature: ACTIVE 46
comment: SPECIES_TYPE=PROTEIN

uniprot F1MYM3 246
type: UnificationXref
id: F1MYM3
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot P48736 287
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H2PXY8 265
xref: PTHR10048:SF35
organism: Pan troglodytes

ncbitaxon 9615 11
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot F7GNE4 424
type: UnificationXref
id: F7GNE4
db: uniprot

uniprot Q9WUA6 357
type: UnificationXref
id: Q9WUA6
db: uniprot

uniprot E2RSX2 312
type: UnificationXref
id: E2RSX2
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9WTY9 43
xref: PTHR24055:SF107
organism: Rattus norvegicus

p53 s48 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

uniprot P23696 193
type: UnificationXref
id: P23696
db: uniprot

uniprot Q567Y8 205
type: UnificationXref
id: Q567Y8
db: uniprot

cyclin E s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cyclin E
stoichiometric coefficient: 1.0

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

uniprot A0A1D5QE27 223
type: UnificationXref
id: A0A1D5QE27
db: uniprot

uniprot B7QGY5 178
type: UnificationXref
id: B7QGY5
db: uniprot

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 177

uniprot H2QNY5 388
type: UnificationXref
id: H2QNY5
db: uniprot

uniprot G5EGK8 191
type: UnificationXref
id: G5EGK8
db: uniprot

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 325

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

p14 19 ARF s19 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p14/19 ARF
stoichiometric coefficient: 1.0

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P27986 284
organism: Homo sapiens

PP2A C s16 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PP2A-C
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re104 496
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

uniprot Q12236 132
type: UnificationXref
id: Q12236
db: uniprot

PARTICIPANT STOICHIOMETRY re104 497
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re104 498
type: Stoichiometry
physical entity: Complex (p53/MDM-2)
stoichiometric coefficient: 1.0

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Mus musculus

uniprot E2RCV1 239
type: UnificationXref
id: E2RCV1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q1X3 105
xref: PTHR24056:SF254
organism: Macaca mulatta

uniprot F6XP81 343
type: UnificationXref
id: F6XP81
db: uniprot

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot E9QAN8 244
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re83 486
type: Stoichiometry
physical entity: PDK1/2
stoichiometric coefficient: 1.0

MDM 2 s59 sa19 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5
comment: MODIFICATION_RESIDUE_NAME=

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PARTICIPANT STOICHIOMETRY re83 485
type: Stoichiometry
physical entity: PDK1/2
stoichiometric coefficient: 1.0

PTHR10177:SF344
type: RelationshipXref
id: PTHR10177:SF344
db: PANTHER Family
relationship type: By Homology

uniprot F7GEK1 344
type: UnificationXref
id: F7GEK1
db: uniprot

uniprot Q7ZUL8 101
type: UnificationXref
id: Q7ZUL8
db: uniprot

Catenin beta-1
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot Q9WU82 431
organism: Rattus norvegicus

uniprot F7F3S0 260
type: UnificationXref
id: F7F3S0
db: uniprot

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q9Z2A0 142
xref: PTHR24356:SF163
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re69 519
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

Cyclin-A2
type: ProteinReference
xref: uniprot F1NJI2 360
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY re69 518
type: Stoichiometry
physical entity: Wnt pathway
stoichiometric coefficient: 1.0

uniprot Q62388 416
type: UnificationXref
id: Q62388
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 134

PIP-2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

MDM 2 s37 sa17 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.78

PARTICIPANT STOICHIOMETRY re31 534
type: Stoichiometry
physical entity: Complex (cyclin E/cdk2/ p21)
stoichiometric coefficient: 1.0

ncbitaxon 9913 4
type: UnificationXref
id: 9913
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re31 533
type: Stoichiometry
physical entity: Complex (cyclin E/cdk2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 532
type: Stoichiometry
physical entity: p21
stoichiometric coefficient: 1.0

uniprot G5EE01 162
type: UnificationXref
id: G5EE01
db: uniprot

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot O55173 128
xref: PTHR24356:SF163
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P26450 283
organism: Mus musculus

uniprot P51959 318
type: UnificationXref
id: P51959
db: uniprot

uniprot E2RSB0 12
type: UnificationXref
id: E2RSB0
db: uniprot

uniprot O08586 163
type: UnificationXref
id: O08586
db: uniprot

uniprot A0A3Q1LTT9 7
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot O00443 270
organism: Homo sapiens

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O02812 21
xref: PTHR24055:SF110
organism: Canis lupus familiaris

uniprot Q03407 131
type: UnificationXref
id: Q03407
db: uniprot

uniprot A0A3Q1LQK4 231
type: UnificationXref
id: A0A3Q1LQK4
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RKA7 10
xref: PTHR24055:SF107
organism: Canis lupus familiaris

MDM 2 s37 sa17 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q7ZVG6 219
type: UnificationXref
id: Q7ZVG6
db: uniprot

uniprot F6RCU6 342
type: UnificationXref
id: F6RCU6
db: uniprot

PTHR24056:SF254
type: RelationshipXref
id: PTHR24056:SF254
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot F6VTR8 252
organism: Macaca mulatta

MDM 2 s68 a120 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.78

TRANSLATION_LEFT__SIAH_1-RIGHT__SIAH_1-_re108
type: TemplateReaction
product: SIAH-1
xref: TRANSLATION
participant: SIAH-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot A0A3Q1LJZ7 3
type: UnificationXref
id: A0A3Q1LJZ7
db: uniprot

cdk2
type: Protein
entity reference: cdk2
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa2 466
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase ATR
type: ProteinReference
xref: uniprot Q9JKK8 417
xref: PTHR11139:SF69
organism: Mus musculus

PI-3 kinase
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot P91634 293
organism: Drosophila melanogaster

Rb s23 a62 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Uncharacterized protein
type: DnaReference
xref: PTHR12305:SF81
organism: Macaca mulatta

uniprot Q920M9 221
type: UnificationXref
id: Q920M9
db: uniprot

uniprot D3ZFJ0 234
type: UnificationXref
id: D3ZFJ0
db: uniprot

PARTICIPANT STOICHIOMETRY re52 481
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 26

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re52 482
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

uniprot F1PQ32 116
type: UnificationXref
id: F1PQ32
db: uniprot

uniprot Q9XF67 139
type: UnificationXref
id: Q9XF67
db: uniprot

E3 ubiquitin-protein ligase
type: ProteinReference
xref: PTHR45877:SF1
xref: uniprot K7B016 216
organism: Pan troglodytes

SIAH-1
type: ProteinReference
xref: P04660
standard name: Seven in absentia homolog 1
comment: ENTITY_REFERENCE_NOTES= Long Name: SIAH-1 Synonym: Synonym not specified Accession: P04660
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.SIAH-1
member entity reference: E3 ubiquitin-protein ligase SIAH1B
member entity reference: E3 ubiquitin-protein ligase SIAH1A
member entity reference: E3 ubiquitin-protein ligase
member entity reference: E3 ubiquitin-protein ligase Siah1
member entity reference: E3 ubiquitin-protein ligase SIAH1

MDM 2 s37 sa17 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5
comment: MODIFICATION_RESIDUE_NAME=

uniprot F6SW23 147
type: UnificationXref
id: F6SW23
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O00459 271
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re101
controller: AKT

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7HSM1 190
xref: PTHR45619:SF44
organism: Macaca mulatta

uniprot F1MBU9 245
type: UnificationXref
id: F1MBU9
db: uniprot

uniprot P28749 121
type: UnificationXref
id: P28749
db: uniprot

uniprot P47811 31
type: UnificationXref
id: P47811
db: uniprot

uniprot E1BMX0 70
type: UnificationXref
id: E1BMX0
db: uniprot

Tumor protein 63
type: ProteinReference
xref: uniprot O88898 390
xref: PTHR11447:SF8
organism: Mus musculus

Cyclin-G1
type: DnaReference
organism: Homo sapiens

uniprot D4AA88 379
type: UnificationXref
id: D4AA88
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 63

uniprot P32883 89
type: UnificationXref
id: P32883
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9N272 42
xref: PTHR24055:SF107
organism: Pan troglodytes

cyclin A
type: Protein
entity reference: cyclin A
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa8 468
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F6SZ66 249
type: UnificationXref
id: F6SZ66
db: uniprot

Cyclin A2
type: ProteinReference
xref: uniprot E2RQA2 359
organism: Canis lupus familiaris

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

uniprot F6VAQ8 251
type: UnificationXref
id: F6VAQ8
db: uniprot

Serine/threonine-protein kinase PKH1
type: ProteinReference
xref: PTHR24356:SF368
xref: uniprot Q03407 131
organism: Saccharomyces cerevisiae

STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_re84
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re84 484
participant stoichiometry: PARTICIPANT STOICHIOMETRY re84 483
left: AKT
interaction type: STATE_TRANSITION
right: AKT

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot P08644 86
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TXC2 13
xref: PTHR24055:SF107
organism: Monodelphis domestica

E2F transcription factor 3
type: ProteinReference
xref: uniprot F6VW96 103
xref: PTHR12081:SF44
organism: Xenopus tropicalis

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

GTPase HRas
type: ProteinReference
xref: uniprot P08642 85
xref: PTHR24070:SF423
organism: Gallus gallus

STATE_TRANSITION_LEFT__Complex__p53_MDM_2_-RIGHT__Complex__p53_MDM_2_-_re105
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re105 495
participant stoichiometry: PARTICIPANT STOICHIOMETRY re105 494
left: Complex (p53/MDM-2)
interaction type: STATE_TRANSITION
right: Complex (p53/MDM-2)

uniprot F7E5M4 188
type: UnificationXref
id: F7E5M4
db: uniprot

S46 p53 s30 a74 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S46
feature location: S46 p53 s30 a74 rs3 S46
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.934482691359872
comment: MODIFICATION_RESIDUE_NAME=S46

Uncharacterized protein
type: DnaReference
organism: Bos taurus

uniprot E2QW70 107
type: UnificationXref
id: E2QW70
db: uniprot

Rb s18 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rb
stoichiometric coefficient: 1.0

uniprot Q9JHG7 308
type: UnificationXref
id: Q9JHG7
db: uniprot

P04662
type: UnificationXref
id: P04662
db: PANTHER Pathway Component

P04661
type: UnificationXref
id: P04661
db: PANTHER Pathway Component

P04660
type: UnificationXref
id: P04660
db: PANTHER Pathway Component

P04667
type: UnificationXref
id: P04667
db: PANTHER Pathway Component

P04666
type: UnificationXref
id: P04666
db: PANTHER Pathway Component

MDM 2 s4 a59 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6V332 15
organism: Macaca mulatta

uniprot A0A2I3S6S7 226
type: UnificationXref
id: A0A2I3S6S7
db: uniprot

P04665
type: UnificationXref
id: P04665
db: PANTHER Pathway Component

P04664
type: UnificationXref
id: P04664
db: PANTHER Pathway Component

P04659
type: UnificationXref
id: P04659
db: PANTHER Pathway Component

Complex (p53/MDM-2)
type: Complex
component stoichiometry: p53 s48 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: MDM 2 s59 sa19 STOICHIOMETRY ID COMPLEX
component: p53
component: MDM-2
feature: COMPLEX BINDING FEATURE s89 a142 443
feature: COMPLEX BINDING FEATURE s89 a142 445
cellular location: nucleus

TRANSCRIPTION
type: RelationshipTypeVocabulary

P04657
type: UnificationXref
id: P04657
db: PANTHER Pathway Component

P04658
type: UnificationXref
id: P04658
db: PANTHER Pathway Component

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot A0A3Q1LTT9 7
organism: Bos taurus

uniprot E7FC59 157
type: UnificationXref
id: E7FC59
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re52
controller: Complex (cyclin G/PP2A-C)

S46 p53 s48 sa18 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S46
feature location: S46 p53 s48 sa18 rs3 S46
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.934482691359872
comment: MODIFICATION_RESIDUE_NAME=S46

uniprot P06400 119
type: UnificationXref
id: P06400
db: uniprot

cyclin E
type: ProteinReference
xref: P04664
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.PROTEIN.GENERIC.cyclin E
comment: ENTITY_REFERENCE_NOTES=
member entity reference: G1/S-specific cyclin-E1
member entity reference: Uncharacterized protein
member entity reference: CCNE1 isoform 1

RB transcriptional corepressor-like 1
type: ProteinReference
xref: uniprot D3ZS28 112
organism: Rattus norvegicus

Serine/threonine-protein phosphatase PP2A catalytic subunit
type: ProteinReference
xref: uniprot Q9HFQ2 210
organism: Emericella nidulans

P21
type: DnaRegion
entity reference: P21
cellular location: nucleus
comment: SPECIES_TYPE=GENE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__p53_MDM_2_-RIGHT__Complex__p53_MDM_2_-_re105
controller: Complex (p53/MDM-2)

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 170

uniprot F6VBA7 160
type: UnificationXref
id: F6VBA7
db: uniprot

uniprot P42338 285
type: UnificationXref
id: P42338
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot P38936 374
type: UnificationXref
id: P38936
db: uniprot

P04652
type: UnificationXref
id: P04652
db: PANTHER Pathway Component

P04651
type: UnificationXref
id: P04651
db: PANTHER Pathway Component

MDM 2 s4 a59 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5
comment: MODIFICATION_RESIDUE_NAME=

P04654
type: UnificationXref
id: P04654
db: PANTHER Pathway Component

uniprot H2QRH7 192
type: UnificationXref
id: H2QRH7
db: uniprot

P04653
type: UnificationXref
id: P04653
db: PANTHER Pathway Component

P04656
type: UnificationXref
id: P04656
db: PANTHER Pathway Component

E3 ubiquitin-protein ligase SIAH1
type: DnaReference
xref: PTHR45877:SF1
organism: Homo sapiens

P04648
type: UnificationXref
id: P04648
db: PANTHER Pathway Component

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: uniprot F1QNG4 74
xref: PTHR24070:SF423
organism: Danio rerio

P04649
type: UnificationXref
id: P04649
db: PANTHER Pathway Component

uniprot B3S653 176
type: UnificationXref
id: B3S653
db: uniprot

PI3K s25 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

uniprot D4ACL8 403
type: UnificationXref
id: D4ACL8
db: uniprot

uniprot C3XQF4 180
type: UnificationXref
id: C3XQF4
db: uniprot

PARTICIPANT STOICHIOMETRY re84 483
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

uniprot Q6AY13 371
type: UnificationXref
id: Q6AY13
db: uniprot

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 322

PARTICIPANT STOICHIOMETRY re84 484
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

uniprot E2RQA2 359
type: UnificationXref
id: E2RQA2
db: uniprot

uniprot Q27368 104
type: UnificationXref
id: Q27368
db: uniprot

uniprot H2R2U1 425
type: UnificationXref
id: H2R2U1
db: uniprot

uniprot H2RFJ9 373
type: UnificationXref
id: H2RFJ9
db: uniprot

uniprot Q9Y243 358
type: UnificationXref
id: Q9Y243
db: uniprot

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 52

uniprot F1Q6Z7 184
type: UnificationXref
id: F1Q6Z7
db: uniprot

Cyclin-A1
type: ProteinReference
xref: uniprot P78396 369
organism: Homo sapiens

Cyclin-G1
type: DnaReference
xref: PTHR10177:SF59
organism: Bos taurus

uniprot G3X6J7 386
type: UnificationXref
id: G3X6J7
db: uniprot

PARTICIPANT STOICHIOMETRY re61 541
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__p38_MAPK-RIGHT__p38_MAPK-_re47
control type: ACTIVATION
controller: Ras pathway

uniprot P39949 326
type: UnificationXref
id: P39949
db: uniprot

PI3K
type: Protein
entity reference: PI3K
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa14 460
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re61 540
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase VPS34-like
type: ProteinReference
xref: uniprot P54676 292
xref: PTHR10048:SF7
organism: Dictyostelium discoideum

KNOWN_TRANSITION_OMITTED_LEFT__Wnt_pathway-RIGHT__beta_catenin-_re69
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 519
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 518
left: Wnt pathway
interaction type: KNOWN_TRANSITION_OMITTED
right: beta-catenin

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F1MYM3 246
organism: Bos taurus

Phosphatidylinositol 3-kinase 3
type: ProteinReference
xref: PTHR10048:SF48
xref: uniprot P54675 291
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 2
type: ProteinReference
xref: uniprot P54674 290
xref: PTHR10048:SF109
organism: Dictyostelium discoideum

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 174

Phosphatidylinositol 3-kinase 1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot P54673 289
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FZG0 314
xref: PTHR10177:SF59
organism: Monodelphis domestica

PTHR10177:SF71
type: RelationshipXref
id: PTHR10177:SF71
db: PANTHER Family
relationship type: By Homology

Cyclin-A2
type: ProteinReference
xref: uniprot P30274 367
organism: Bos taurus

MDM 2 s68 a120 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q8T9S7 169
type: UnificationXref
id: Q8T9S7
db: uniprot

uniprot Q12526 92
type: UnificationXref
id: Q12526
db: uniprot

PTHR45619:SF42
type: RelationshipXref
id: PTHR45619:SF42
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot A7T2Q5 173
organism: Nematostella vectensis

uniprot P67775 203
type: UnificationXref
id: P67775
db: uniprot

uniprot Q8INB9 355
type: UnificationXref
id: Q8INB9
db: uniprot

uniprot F7FZG0 314
type: UnificationXref
id: F7FZG0
db: uniprot

uniprot Q9Z1B7 45
type: UnificationXref
id: Q9Z1B7
db: uniprot

ATR serine/threonine kinase
type: ProteinReference
xref: uniprot E2QXA4 405
xref: PTHR11139:SF69
organism: Canis lupus familiaris

Cyclin-dependent kinase inhibitor 1A
type: DnaReference
xref: PTHR46778:SF1
organism: Rattus norvegicus

MCG118205, isoform CRA_c
type: ProteinReference
xref: uniprot G5E8H5 161
organism: Mus musculus

PTHR10177:SF59
type: RelationshipXref
id: PTHR10177:SF59
db: PANTHER Family
relationship type: By Homology

Rb s24 a63 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot P09416 56
type: UnificationXref
id: P09416
db: uniprot

PTHR45619:SF44
type: RelationshipXref
id: PTHR45619:SF44
db: PANTHER Family
relationship type: By Homology

uniprot O08911 23
type: UnificationXref
id: O08911
db: uniprot

Pi3K21B, isoform B
type: ProteinReference
xref: uniprot Q7KTZ2 300
xref: PTHR10155:SF10
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot A0A1D5QJY6 224
organism: Macaca mulatta

MDM 2 s68 a120 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.5
comment: MODIFICATION_RESIDUE_NAME=

uniprot P67774 202
type: UnificationXref
id: P67774
db: uniprot

S33 p53 s46 a92 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S33
feature location: S33 p53 s46 a92 rs2 S33
comment: MODIFICATION_RESIDUE_ANGLE=2.3412474663214593
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S33

Serine/threonine-protein kinase ATR
type: ProteinReference
xref: uniprot Q9VXG8 418
organism: Drosophila melanogaster

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Monodelphis domestica

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Gallus gallus

uniprot P31749 347
type: UnificationXref
id: P31749
db: uniprot

Phosphoinositide 3-kinase regulatory subunit 5
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot Q8WYR1 305
organism: Homo sapiens

beta-catenin
type: Protein
entity reference: beta-catenin
feature: beta catenin s58 a109 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q3T0N5 36
organism: Bos taurus

STATE_TRANSITION_LEFT__Rb-RIGHT__Rb-_re35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 523
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 522
left: Rb
interaction type: STATE_TRANSITION
right: Rb

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Mus musculus

p14/19 ARF
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 5786 183
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot Q803G3 209
type: UnificationXref
id: Q803G3
db: uniprot

uniprot Q95ME4 102
type: UnificationXref
id: Q95ME4
db: uniprot

CCNA1 isoform 3
type: ProteinReference
xref: uniprot G2HFV8 363
organism: Pan troglodytes

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P67775 203
xref: PTHR45619:SF42
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot P67774 202
organism: Bos taurus

uniprot B1WB72 333
type: UnificationXref
id: B1WB72
db: uniprot

Wildtype p53-induced phosphatase
type: DnaRegionReference
member entity reference: Protein phosphatase 1D
member entity reference: Uncharacterized protein
member entity reference: PPM1D isoform 1
member entity reference: Ppm1d protein
xref: G04708
comment: ENTITY_REFERENCE_NOTES= Long Name: WIP-1 Synonym: PPM1D,protein phosphatase, magnesium-dependent, 1, delta isoform Accession: G04708
comment: ENTITY_REFERENCE_ID_DESC=p53 pathway feedback loops 2.GENE.GENE.WIP-1
display name: WIP-1

MDM-2
type: DnaRegion
entity reference: Mouse double minute 2
cellular location: nucleus
comment: SPECIES_TYPE=GENE

uniprot P48736 287
type: UnificationXref
id: P48736
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

Myc
type: Protein
entity reference: Myc
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase PP2A catalytic subunit
type: ProteinReference
xref: uniprot P48580 195
organism: Neurospora crassa

uniprot Q64315 376
type: UnificationXref
id: Q64315
db: uniprot

TRANSLATION_LEFT__Wip_1-RIGHT__Wip1-_re110
type: TemplateReaction
product: Wip1
xref: TRANSLATION
participant: Wip1
participant: Wip-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot Q28EW2 94
xref: PTHR24070:SF423
organism: Xenopus tropicalis

KRAS isoform 4
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot A0A2I3T6U4 65
organism: Pan troglodytes

uniprot P42339 286
type: UnificationXref
id: P42339
db: uniprot

uniprot F6VW96 103
type: UnificationXref
id: F6VW96
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot F1NT98 159
xref: PTHR12305:SF81
organism: Gallus gallus

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Macaca mulatta

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q16539 35
xref: PTHR24055:SF110
organism: Homo sapiens

uniprot Q90600 124
type: UnificationXref
id: Q90600
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E9I1I7 71
xref: PTHR24070:SF420
organism: Daphnia pulex

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MYJ4 336
xref: PTHR24356:SF190
organism: Bos taurus

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot O54857 164
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__MDM_2-RIGHT__MDM_2-_re113
control type: ACTIVATION
controller: p53

uniprot F6U7A6 185
type: UnificationXref
id: F6U7A6
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot Q8IUQ4 220
type: UnificationXref
id: Q8IUQ4
db: uniprot

ncbitaxon 7227 30
type: UnificationXref
id: 7227
db: ncbitaxon

cyclin E
type: Protein
entity reference: cyclin E
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa3 434
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PTHR10155:SF10
type: RelationshipXref
id: PTHR10155:SF10
db: PANTHER Family
relationship type: By Homology

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

uniprot B6V8E6 419
type: UnificationXref
id: B6V8E6
db: uniprot

Serine/threonine-protein kinase tel1
type: ProteinReference
xref: uniprot O74630 410
organism: Schizosaccharomyces pombe

uniprot E2QXA4 405
type: UnificationXref
id: E2QXA4
db: uniprot

uniprot Q9W0V1 138
type: UnificationXref
id: Q9W0V1
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RJX4 334
xref: PTHR24356:SF171
organism: Canis lupus familiaris

uniprot F7DUD6 149
type: UnificationXref
id: F7DUD6
db: uniprot

uniprot E2RH85 240
type: UnificationXref
id: E2RH85
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__SIAH_1-RIGHT__SIAH_1-_re107
control type: ACTIVATION
controller: p53

PTHR45619:SF12
type: RelationshipXref
id: PTHR45619:SF12
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re34
controller: ATM

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot H2QNG6 268
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1Q4F8 338
xref: PTHR24356:SF190
organism: Canis lupus familiaris

Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F7BZL6 258
organism: Macaca mulatta

By Homology
type: RelationshipTypeVocabulary

uniprot K7B016 216
type: UnificationXref
id: K7B016
db: uniprot

uniprot P35222 427
type: UnificationXref
id: P35222
db: uniprot

uniprot F6X958 186
type: UnificationXref
id: F6X958
db: uniprot

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 64

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot O46404 275
organism: Bos taurus

uniprot P08642 85
type: UnificationXref
id: P08642
db: uniprot

uniprot Q63788 295
type: UnificationXref
id: Q63788
db: uniprot

Serine-protein kinase ATM
type: ProteinReference
xref: uniprot Q62388 416
organism: Mus musculus

uniprot F1NQ71 321
type: UnificationXref
id: F1NQ71
db: uniprot

uniprot Q9H3D4 398
type: UnificationXref
id: Q9H3D4
db: uniprot

eco ECO:0000304 52
type: UnificationXref
id: ECO:0000304
db: eco

TRANSCRIPTION_LEFT__SIAH_1-RIGHT__SIAH_1-_re107
type: TemplateReaction
product: SIAH-1
xref: TRANSCRIPTION
participant: SIAH-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Catenin beta-1
type: ProteinReference
xref: uniprot Q0VCX4 429
xref: PTHR45976:SF4
organism: Bos taurus

MDM 2 s4 a59 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.78

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q7PD38 208
xref: PTHR45619:SF12
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY re98 526
type: Stoichiometry
physical entity: MDM-2
stoichiometric coefficient: 1.0

uniprot C8VB89 402
type: UnificationXref
id: C8VB89
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot B3S653 176
xref: PTHR45619:SF12
organism: Trichoplax adhaerens

PIK3CG isoform 1
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot A0A2J8QY32 230
organism: Pan troglodytes

P110alpha s29 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: P110alpha
stoichiometric coefficient: 1.0

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P67939 395
xref: PTHR11447:SF6
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re98 527
type: Stoichiometry
physical entity: a132_degraded
stoichiometric coefficient: 1.0

uniprot Q03306 129
type: UnificationXref
id: Q03306
db: uniprot

uniprot F0ZDJ1 182
type: UnificationXref
id: F0ZDJ1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MDM_2-RIGHT__MDM_2-_re34
controller: Complex (cyclin A/cdk2)

CCNG1 isoform 2
type: DnaReference
organism: Pan troglodytes

Rb
type: Protein
entity reference: Rb
feature: Rb s23 a62 rs1
feature: ACTIVE 46
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

RB transcriptional corepressor like 1
type: ProteinReference
xref: uniprot E2RQ78 114
organism: Canis lupus familiaris