2.2 OVAL SQUARE_CLOSEUP_NORTH SQUARE_CLOSEUP_NORTH inactive inactive active active inactive active active inactive active inactive active active inactive active inactive inactive inactive active active active inactive active active active active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive active inactive inactive active active inactive active active active active inactive inactive inactive active active active inactive inactive active inactive inactive inactive active active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active active active inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive active inactive active inactive active active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive active inactive active active inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive active inactive inactive active inactive active inactive active active inactive active inactive inactive active inactive active inactive active inactive inactive active inactive active inactive active inactive inactive active active active inactive Mitochondria Nucleus Intracellular Long Name: Tumor necrosis factor receptor 1 Synonym: Synonym not specified Accession: P00288 transmembrane PROTEIN p1 Long Name: Tumor necrosis factor Synonym: Synonym not specified Accession: P00259 inside PROTEIN p2 Long Name: TNFR1 associated death domain Synonym: Synonym not specified Accession: P00319 inside PROTEIN p3 Long Name: Receptor interacting protein Synonym: RIPK1,Receptor-interacting serine/threonine kinase 1 Accession: P00315 inside PROTEIN p5 Long Name: RIP associated ICH-1/CED homologous protein with death domain Synonym: CRADD,Casp2 and RIPK1 domain-containing adaptor with death domain,Caspase and RIP adaptor with death domain Accession: P00294 inside PROTEIN p6 Long Name: Silencer of death domains Synonym: Bag4,Bcl2-associated athanogene 4 Accession: P00320 inside PROTEIN p9 Long Name: Bcl-2 antogonist/killer Synonym: Synonym not specified Accession: P00275 transmembrane PROTEIN p17 Long Name: Bcl-2/Bcl-xL associated death promoter Synonym: Bcl2 antagonist of cell death Accession: P00281 inside PROTEIN p18 Long Name: Bim Synonym: Bcl2 interacting protein,Bcl2-like 11 Accession: P00325 inside PROTEIN p19 Long Name: Bcl-2 related ovarian killer Synonym: Synonym not specified Accession: P00261 inside PROTEIN p20 Long Name: Bcl2-related protein short isoform Synonym: Synonym not specified Accession: P00323 inside PROTEIN p21 Long Name: Bcl-2 Synonym: B-cell Leukemia 2 Accession: P00270 inside PROTEIN p22 Long Name: Bcl2-related protein long isoform Synonym: Synonym not specified Accession: P00257 inside PROTEIN p23 Long Name: Bcl-2 interacting killer Synonym: Synonym not specified Accession: P00258 inside PROTEIN p24 Long Name: Bik-like killer protein Synonym: Synonym not specified Accession: P00290 inside PROTEIN p25 Long Name: Bcl-2 associated anthogene-1 Synonym: Bcl2- associated athanogen 1 Accession: P00278 inside PROTEIN p26 Long Name: Bcl2-related protein A1 Synonym: Bcl2A1,Bfl1 Accession: P00283 inside PROTEIN p27 Long Name: Myeloid cell leukemia 1 Synonym: Synonym not specified Accession: P00308 inside PROTEIN p28 Long Name: Bcl-w Synonym: Synonym not specified Accession: P00316 inside PROTEIN p29 Long Name: BH-3 interacting domain death agonist Synonym: Synonym not specified Accession: P00262 inside PROTEIN p16 Long Name: Apoptosis inducing factor Synonym: Synonym not specified Accession: P00286 inside PROTEIN p30 Long Name: Endonuclease G Synonym: Synonym not specified Accession: P00279 inside PROTEIN p31 Long Name: Second mitochondria-derived activator of caspase Synonym: Diablo,Direct IAP-binding protein with low PI,Smac Accession: P00309 inside PROTEIN p32 Long Name: Heat shock protein 70 Synonym: Synonym not specified Accession: P00321 inside PROTEIN p33 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05051 Heterodimer Member Info: TRADD#PROTEIN#TNFR1 associated death domain#P00319##;FADD#PROTEIN#Fas associated death domain#P00327## inside PROTEIN p4 PROTEIN p3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05047 Heterodimer Member Info: RAIDD#PROTEIN#RIP associated ICH-1/CED homologous protein with death domain#P00294#CRADD|Casp2 and RIPK1 domain-containing adaptor with death domain|Caspase and RIP adaptor with death domain#;TRAF2#PROTEIN#TNF receptor-associated factor 2#P00306#TRAP#;RIP#PROTEIN#Receptor interacting protein#P00315#RIPK1|Receptor-interacting serine/threonine kinase 1#;TRADD#PROTEIN#TNFR1 associated death domain#P00319## inside PROTEIN p3 PROTEIN p6 PROTEIN p7 PROTEIN p5 Long Name: Bcl-2 associated x protein Synonym: Synonym not specified Accession: P00271 transmembrane PROTEIN p15 Long Name: BH-3 interacting domain death agonist Synonym: Synonym not specified Accession: P00262 transmembrane PROTEIN p16 Long Name: Apoptosis inducing factor Synonym: Synonym not specified Accession: P00286 inside PROTEIN p30 Long Name: Endonuclease G Synonym: Synonym not specified Accession: P00279 inside PROTEIN p31 Long Name: Second mitochondria-derived activator of caspase Synonym: Diablo,Direct IAP-binding protein with low PI,Smac Accession: P00309 inside PROTEIN p32 Long Name: Nuclear factor kappa-B Synonym: Nuclear factor of kappa light chain gene enhancer in B cells Accession: P00297 inside PROTEIN p44 Long Name: Nuclear factor kappa-B Synonym: Nuclear factor of kappa light chain gene enhancer in B cells Accession: P00297 inside PROTEIN p44 Long Name: Anti-apoptosis Synonym: Synonym not specified Accession: U02108 inside PHENOTYPE Anti-apoptosis Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00292 inside PROTEIN p43 Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00292 inside PROTEIN p43 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05050 Heterodimer Member Info: IkappaB#PROTEIN#Inhibitor of kappa light chain gene enhancer in B cells#P00292#Nuclear factor of kappa light chain gene enhancer in B cells inhibitor#;NFkappaB#PROTEIN#Nuclear factor kappa-B#P00297#Nuclear factor of kappa light chain gene enhancer in B cells# inside PROTEIN p43 PROTEIN p44 Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00292 inside PROTEIN p43 Long Name: a127_degraded Synonym: Synonym not specified Accession: U02110 inside DEGRADED a127_degraded Long Name: SAPK/ERK kinasae 1 Synonym: JNK-activated kinase 1,JNKK1,MAPKK4,MEK4,MKK4,Mitogen activated protein kinase kinase 4 Accession: P00266 inside PROTEIN p51 Long Name: SAPK/ERK kinasae 1 Synonym: JNK-activated kinase 1,JNKK1,MAPKK4,MEK4,MKK4,Mitogen activated protein kinase kinase 4 Accession: P00266 inside PROTEIN p51 Long Name: Mitogen activated protein kinase kinase 7 Synonym: JNK-activating kinase 2,JNKK2,MAP kinase kinase 7,MAPKK7 Accession: P00312 inside PROTEIN p50 Long Name: Mitogen activated protein kinase kinase 7 Synonym: JNK-activating kinase 2,JNKK2,MAP kinase kinase 7,MAPKK7 Accession: P00312 inside PROTEIN p50 Long Name: Mitogen-activated protein kinase kinase kinase 1 Synonym: MAPKKK1,MEK kinase,Map/Erk kinase kinase 1 Accession: P00291 inside PROTEIN p48 Long Name: Mitogen-activated protein kinase kinase kinase 1 Synonym: MAPKKK1,MEK kinase,Map/Erk kinase kinase 1 Accession: P00291 inside PROTEIN p48 Long Name: Jun kinase Synonym: c-Jun amino-terminal kinase Accession: P00274 inside PROTEIN p49 Long Name: Jun kinase Synonym: c-Jun amino-terminal kinase Accession: P00274 inside PROTEIN p49 Long Name: Mitogen activated protein kinase Synonym: MAP kinase Accession: P00269 inside PROTEIN p47 Long Name: Mitogen activated protein kinase Synonym: MAP kinase Accession: P00269 inside PROTEIN p47 Long Name: Mitogen activated protein kinase kinase 3 Synonym: MAP kinase kinase 3,MAPKK3 Accession: P00314 inside PROTEIN p46 Long Name: Mitogen activated protein kinase kinase 3 Synonym: MAP kinase kinase 3,MAPKK3 Accession: P00314 inside PROTEIN p46 Long Name: Activating transcription factor Synonym: Synonym not specified Accession: P00302 inside PROTEIN p52 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05048 Heterodimer Member Info: c-Jun#PROTEIN#c-Jun#P00303##;Fos#PROTEIN#Fos#P00317#V-fos FBJ murine osteosarcoma viral oncogene homolog# inside PROTEIN p53 PROTEIN p54 Long Name: Pro-apoptotic Synonym: Synonym not specified Accession: U02111 inside PHENOTYPE Pro-apoptotic Long Name: Tumor necrosis factor receptor 2 Synonym: Synonym not specified Accession: P00287 transmembrane PROTEIN p55 Long Name: Mitogen activated protein kinase activating death domain Synonym: DENN Accession: P00267 inside PROTEIN p56 Long Name: FAS Synonym: APO1,APT1,Apoptosis antigen 1,CD95,TNFRSF6,Tumor necrosis factor receptor superfamily member 6 Accession: P00289 transmembrane PROTEIN p57 Long Name: FAS ligand Synonym: APO-1 ligand,APT1LG1,CD95L,FASL,TNFSF6,Tumor necrosis factor ligand superfamily member 6 Accession: P00326 inside PROTEIN p58 Long Name: Death-associated protein 6 Synonym: Synonym not specified Accession: P00296 inside PROTEIN p59 Long Name: TRAIL-receptor Synonym: APO2,Death receptor 4,TNFRSF10A,Tumor necrosis factor receptor superfamily, member 10A Accession: P00276 transmembrane PROTEIN p60 Long Name: TNF-related apoptosis inducing ligand Synonym: APO2 ligand,APO2L Accession: P00263 inside PROTEIN p61 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05044 Heterodimer Member Info: TRAIL#PROTEIN#TNF-related apoptosis inducing ligand#P00263#APO2 ligand|APO2L#;TRAIL-R#PROTEIN#TRAIL-receptor#P00276#APO2|Death receptor 4|TNFRSF10A|Tumor necrosis factor receptor superfamily, member 10A# transmembrane PROTEIN p60 PROTEIN p61 Long Name: Unknown adaptor Synonym: Synonym not specified Accession: U02109 inside UNKNOWN Unknown_br_adaptor Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05043 Heterodimer Member Info: Bax#PROTEIN#Bcl-2 associated x protein#P00271##;Bak#PROTEIN#Bcl-2 antogonist/killer#P00275## inside PROTEIN p15 PROTEIN p17 Long Name: Cytochrome C Synonym: Synonym not specified Accession: P00322 inside PROTEIN p62 Long Name: Cytochrome C Synonym: Synonym not specified Accession: P00322 inside PROTEIN p62 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05049 Heterodimer Member Info: Bik#PROTEIN#Bcl-2 interacting killer#P00258##;Bcl-2#PROTEIN#Bcl-2#P00270#B-cell Leukemia 2# inside PROTEIN p22 PROTEIN p24 Long Name: Bax inhibitor-1 Synonym: Synonym not specified Accession: P00277 inside PROTEIN p64 Long Name: Diva Synonym: Bcl2-like 10,Bcl2L10 Accession: P00285 inside PROTEIN p67 Long Name: Insulin-like growth factor II receptor Synonym: CIMPR,Cation independent mannose-6-phosphate receptor,MPRI,Mannose 6-phosphate receptor, cation independent Accession: P00282 transmembrane PROTEIN p72 Long Name: Granzyme B Synonym: CGL1,CTLA1,Cathepsin G-like 1,Cytotoxic T-Lymphocyte-associated serine esterase 1,GZMB Accession: P00265 inside PROTEIN p73 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05040 Heterodimer Member Info: Granzyme B#PROTEIN#Granzyme B#P00265#CGL1|CTLA1|Cathepsin G-like 1|Cytotoxic T-Lymphocyte-associated serine esterase 1|GZMB#;IGFR2#PROTEIN#Insulin-like growth factor II receptor#P00282#CIMPR|Cation independent mannose-6-phosphate receptor|MPRI|Mannose 6-phosphate receptor, cation independent# transmembrane PROTEIN p72 PROTEIN p73 Long Name: ds-RNA Synonym: Synonym not specified Accession: G01495 inside RNA ds-RNA Long Name: Tumor protein p53 Synonym: TP53,Transformation regulated protein 53 Accession: P00273 Pathway Link: P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1*P00059|P01485|p53 pathway inside PROTEIN p78 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05046 Heterodimer Member Info: TNF#PROTEIN#Tumor necrosis factor#P00259##;TNFR1#PROTEIN#Tumor necrosis factor receptor 1#P00288## transmembrane PROTEIN p1 3 PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05041 Heterodimer Member Info: TNF#PROTEIN#Tumor necrosis factor#P00259##;MADD#PROTEIN#Mitogen activated protein kinase activating death domain#P00267#DENN#;TNFR1#PROTEIN#Tumor necrosis factor receptor 1#P00288## transmembrane PROTEIN p1 3 PROTEIN p2 PROTEIN p56 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05045 Heterodimer Member Info: TNF#PROTEIN#Tumor necrosis factor#P00259##;TNFR2#PROTEIN#Tumor necrosis factor receptor 2#P00287## transmembrane PROTEIN p55 3 PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05052 Heterodimer Member Info: TNF#PROTEIN#Tumor necrosis factor#P00259##;TNFR2#PROTEIN#Tumor necrosis factor receptor 2#P00287##;TRAF2#PROTEIN#TNF receptor-associated factor 2#P00306#TRAP# transmembrane PROTEIN p55 3 PROTEIN p2 PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05042 Heterodimer Member Info: FAS#PROTEIN#FAS#P00289#APO1|APT1|Apoptosis antigen 1|CD95|TNFRSF6|Tumor necrosis factor receptor superfamily member 6#;FAS ligand#PROTEIN#FAS ligand#P00326#APO-1 ligand|APT1LG1|CD95L|FASL|TNFSF6|Tumor necrosis factor ligand superfamily member 6# transmembrane PROTEIN p57 3 PROTEIN p58 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05039 Heterodimer Member Info: FAS#PROTEIN#FAS#P00289#APO1|APT1|Apoptosis antigen 1|CD95|TNFRSF6|Tumor necrosis factor receptor superfamily member 6#;DAXX#PROTEIN#Death-associated protein 6#P00296##;FAS ligand#PROTEIN#FAS ligand#P00326#APO-1 ligand|APT1LG1|CD95L|FASL|TNFSF6|Tumor necrosis factor ligand superfamily member 6#;FADD#PROTEIN#Fas associated death domain#P00327## transmembrane PROTEIN p57 3 PROTEIN p59 PROTEIN p4 PROTEIN p58 Long Name: Fas associated death domain Synonym: Synonym not specified Accession: P00327 inside PROTEIN p4 Long Name: TNF receptor-associated factor 2 Synonym: TRAP Accession: P00306 inside PROTEIN p7 Long Name: Caspase 8 Synonym: Cysteinyl aspartic acid-protease-8 Accession: P00299 inside PROTEIN p8 Long Name: FLICE inhibitory protein Synonym: CFLAR,Casp8- and FADD-like apoptosis regulator,I-FLICE,Inhibitor of FLICE Accession: P00284 inside PROTEIN p10 Long Name: Phosphatidylinostol 3 kinase Synonym: Synonym not specified Accession: P00310 inside PROTEIN p11 Long Name: Protein kinase C Synonym: Synonym not specified Accession: P00318 inside PROTEIN p12 Long Name: Germinal center kinase Synonym: MAP4K2,Mitigen-activated protein kinase kinase kinase kinase 2,Rab8-interacting protein,Rab8IP Accession: P00268 inside PROTEIN p13 Long Name: NF kappa B inducing kinase Synonym: HSNIK,MAPKKK 14,Mitogen activated protein kinase kinase kinase 14 Accession: P00324 inside PROTEIN p14 Long Name: Caspase 10 Synonym: Cysteinyl aspartic acid-protease-10 Accession: P00295 inside PROTEIN p37 Long Name: Caspase 3 Synonym: Cysteinyl aspartic acid-protease-3 Accession: P00305 inside PROTEIN p38 Long Name: Caspase 7 Synonym: Cysteinyl aspartic acid-protease-7 Accession: P00300 inside PROTEIN p39 Long Name: Germinal center kinase related Synonym: MAP4K3,MAP4K4,Mitogen-activated protein kinase kinase kinase kinase 3,Mitogen-activated protein kinase kinase kinase kinase 4 Accession: P00311 inside PROTEIN p40 Long Name: Protein kinase B Synonym: PKB Accession: P00260 inside PROTEIN p41 Long Name: I-kappa B kinase Synonym: Synonym not specified Accession: P00313 inside PROTEIN p42 Long Name: Pro-apoptotic Synonym: Synonym not specified Accession: U02111 inside PHENOTYPE Pro-apoptotic Long Name: Apoptosis signal-regulating kinase-1 Synonym: MAP kinase kinase kinase 5,MAPKKK5,MEKK5,Mitogen activated protein kinase kinase kinase 5 Accession: P00272 inside PROTEIN p45 Long Name: Apoptosis signal-regulating kinase-1 Synonym: MAP kinase kinase kinase 5,MAPKKK5,MEKK5,Mitogen activated protein kinase kinase kinase 5 Accession: P00272 inside PROTEIN p45 Long Name: Apoptosis protease activating factor-1 Synonym: Synonym not specified Accession: P00301 inside PROTEIN p66 Long Name: Cellular inhibitor of apoptosis protein 1 and 2 Synonym: Synonym not specified Accession: P00264 inside PROTEIN p68 Long Name: Caspase 9 Synonym: Cysteinyl aspartic acid-protease-9 Accession: P00298 inside PROTEIN p69 Long Name: Granzyme B Synonym: CGL1,CTLA1,Cathepsin G-like 1,Cytotoxic T-Lymphocyte-associated serine esterase 1,GZMB Accession: P00265 inside PROTEIN p73 Long Name: Interferon-inducible double-stranded RNA-activated protein kinase Synonym: PKR,PRKR Accession: P00293 inside PROTEIN p75 Long Name: Translation initiation factor 2-alpha Synonym: eIF2 alpha Accession: P00307 inside PROTEIN p76 Long Name: X-linked inhibitor of apoptosis Synonym: BIRC4,Baculoviral IAP repeat-containing protein 4 Accession: P00304 inside PROTEIN p77 Long Name: Tumor protein p53 Synonym: TP53,Transformation regulated protein 53 Accession: P00273 Pathway Link: P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1*P00059|P01485|p53 pathway inside PROTEIN p78 Long Name: Protein activator of interon-induced protein kinase Synonym: PKR protein activator,PRKRA,RAX,protein kinase, interferon-inducible double-strand RNA dependent activator Accession: P00280 inside PROTEIN p74 STATE_TRANSITION s217 s217 0.3333333333333335,1.7763568394002505E-15 0.6666666666666667,3.552713678800501E-15 a30 a31 STATE_TRANSITION s219 s219 0.3333333333333339,8.881784197001252E-16 0.6666666666666679,8.881784197001252E-16 a38 a39 STATE_TRANSITION s220 s220 0.3333333333333357,8.881784197001252E-16 0.6666666666666661,1.7763568394002505E-15 a40 a43 STATE_TRANSITION s221 s221 0.3333333333333339,-8.881784197001252E-16 0.666666666666667,-2.6645352591003757E-15 a41 a44 STATE_TRANSITION s222 s222 0.3333333333333339,0.0 0.6666666666666661,0.0 a42 a45 TRANSPORT s30 s31 0.3333333333333326,4.440892098500626E-16 0.6666666666666665,8.881784197001252E-16 a46 a47 STATE_TRANSITION s49 s52 0.3333333333333339,0.0 0.6666666666666661,-8.881784197001252E-16 a64 a50 TRANSPORT s54 s56 0.33333333333333215,0.0 0.6666666666666661,0.0 a67 a69 TRANSPORT s53 s55 0.33333333333333304,0.0 0.6666666666666661,0.0 a66 a68 TRANSPORT s57 s58 0.33333333333333215,1.7763568394002505E-15 0.6666666666666661,0.0 a70 a71 HETERODIMER_ASSOCIATION s7,s215 s70 0.3333333333333339,4.440892098500626E-16 0.6666666666666661,0.0 0.3333333333333337,-8.881784197001252E-16 0.6666666666666659,0.0 0.3333333333333335,0.0 0.6666666666666665,1.7763568394002505E-15 0.33333333333333304,0.3333333333333335 a7 a8 a89 HETERODIMER_ASSOCIATION s7,s10 s74 0.3333333333333339,3.885780586188048E-16 0.6666666666666661,-5.551115123125783E-17 0.3057294159630377,-0.02622007902289436 0.6666666666666672,8.881784197001252E-16 0.33333333333333304,0.0 0.6666666666666665,-6.661338147750939E-16 -0.16975015669369298,0.3560513995618624 a7 a28 a27 a26 a97 STATE_TRANSITION s223 s223 0.3333333333333333,4.440892098500626E-16 0.6666666666666667,8.881784197001252E-16 a98 a101 STATE_TRANSITION s224 s224 0.33333333333333337,5.773159728050814E-15 0.6666666666666669,1.0658141036401503E-14 a99 a102 STATE_TRANSITION s225 s225 0.33333333333333326,-8.881784197001252E-16 0.666666666666667,0.0 a100 a103 STATE_TRANSITION s217 s217 0.3333333333333335,0.0 0.6666666666666665,-2.220446049250313E-16 a32 a31 STATE_TRANSITION s223 s223 0.33333333333333304,2.220446049250313E-16 0.6666666666666665,2.220446049250313E-16 a109 a101 STATE_TRANSITION s226 s226 0.3333333333333339,-4.440892098500626E-16 0.666666666666667,-4.440892098500626E-16 a111 a112 UNKNOWN_TRANSITION s225 s229 0.3333333333333335,8.881784197001252E-16 0.6666666666666674,0.0 a103 a115 UNKNOWN_TRANSITION s224 s229 0.3333333333333335,8.881784197001252E-16 0.6666666666666661,8.881784197001252E-16 a102 a115 STATE_TRANSITION s228 s228 0.33333333333333215,8.881784197001252E-16 0.6666666666666661,1.7763568394002505E-15 a114 a117 STATE_TRANSITION s227 s227 0.33333333333333304,-4.440892098500626E-16 0.6666666666666652,-8.881784197001252E-16 a113 a116 STATE_TRANSITION s95 s98 0.3333333333333339,0.0 0.666666666666667,-8.881784197001252E-16 a118 a121 TRANSPORT s96 s97 0.33333333333333326,-2.220446049250313E-16 0.6666666666666665,-2.220446049250313E-16 a120 a119 UNKNOWN_TRANSITION s97 s100 0.3333333333333339,-3.552713678800501E-15 0.6666666666666696,0.0 a119 a125 HETERODIMER_ASSOCIATION s95,s96 s99 0.33333333333333215,-4.440892098500626E-16 0.6666666666666661,-4.440892098500626E-16 0.3333333333333339,-2.220446049250313E-16 0.6666666666666661,-2.220446049250313E-16 0.3333333333333286,1.7763568394002505E-15 0.6666666666666643,3.552713678800501E-15 0.474030198043917,0.031066330814443432 a118 a120 a124 STATE_TRANSITION s98 s101 0.3333333333333339,0.0 0.666666666666667,-1.7763568394002505E-15 a121 a127 STATE_TRANSITION s101 s102 0.3333333333333339,0.0 0.6666666666666679,0.0 a127 a128 STATE_TRANSITION s230 s231 0.3333333333333335,-8.881784197001252E-16 0.6666666666666665,-1.7763568394002505E-15 a129 a136 STATE_TRANSITION s104 s115 0.33333333333333304,0.0 0.6666666666666665,-8.881784197001252E-16 a130 a137 STATE_TRANSITION s105 s114 0.3333333333333335,-8.881784197001252E-16 0.6666666666666665,-1.7763568394002505E-15 a131 a138 STATE_TRANSITION s106 s112 0.3333333333333339,8.881784197001252E-16 0.666666666666667,2.6645352591003757E-15 a132 a139 STATE_TRANSITION s108 s111 0.33333333333333304,8.881784197001252E-16 0.6666666666666652,2.6645352591003757E-15 a134 a140 STATE_TRANSITION s107 s113 0.33333333333333304,1.7763568394002505E-15 0.6666666666666652,2.6645352591003757E-15 a133 a142 STATE_TRANSITION s109 s110 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666643,-2.6645352591003757E-15 a135 a141 STATE_TRANSITION s117 s117 0.3333333333333339,1.7763568394002505E-15 0.666666666666667,1.7763568394002505E-15 a143 a146 STATE_TRANSITION s123 s123 0.33333333333333304,1.7763568394002505E-15 0.666666666666667,3.552713678800501E-15 a150 a149 UNKNOWN_TRANSITION s117 s124 0.3333333333333339,0.0 0.6666666666666661,-8.881784197001252E-16 a146 a151 UNKNOWN_TRANSITION s123 s124 0.33333333333333415,0.0 0.6666666666666667,8.881784197001252E-16 a149 a151 STATE_TRANSITION s230 s231 0.3333333333333335,-8.881784197001252E-16 0.6666666666666665,-1.7763568394002505E-15 a219 a220 STATE_TRANSITION s217 s217 0.3333333333333335,1.7763568394002505E-15 0.6666666666666667,3.552713678800501E-15 a253 a252 STATE_TRANSITION s223 s223 0.3333333333333333,4.440892098500626E-16 0.6666666666666667,8.881784197001252E-16 a255 a254 STATE_TRANSITION s224 s224 0.3333333333333357,4.440892098500626E-16 0.6666666666666679,2.220446049250313E-15 a263 a262 UNKNOWN_TRANSITION s224 s229 0.33333333333333337,-8.881784197001252E-16 0.6666666666666664,0.0 a262 a265 HETERODIMER_ASSOCIATION s169,s170 s171 0.33333333333333215,-3.552713678800501E-15 0.6666666666666643,-7.105427357601002E-15 0.33333333333333215,0.0 0.6666666666666607,3.552713678800501E-15 0.33333333333333215,0.0 0.6666666666666679,-8.881784197001252E-16 0.33333333333333304,0.3333333333333357 a266 a267 a270 KNOWN_TRANSITION_OMITTED s171 s172 0.33333333333333304,0.0 0.6666666666666661,-1.7763568394002505E-15 a270 a273 HETERODIMER_ASSOCIATION s35,s32 s174 0.33333333333333215,0.0 0.6666666666666643,-3.552713678800501E-15 0.3333333333333357,1.1102230246251565E-16 0.6666666666666643,1.887379141862766E-15 0.3333333333333357,0.0 0.6666666666666679,0.0 0.33333333333333215,0.3333333333333304 a51 a48 a275 DISSOCIATION s174 s35,s32 0.3333333333333357,0.0 0.6666666666666679,-1.7763568394002505E-15 0.3333333333333357,0.0 0.6666666666666714,3.552713678800501E-15 0.3333333333333428,2.9976021664879227E-15 0.6666666666666714,-5.551115123125783E-16 0.3333333333333304,0.33333333333333215 a275 a51 a48 HETERODIMER_ASSOCIATION s42,s40 s175 0.3333333333333286,7.105427357601002E-15 0.6666666666666643,0.0 0.3333333333333357,8.881784197001252E-16 0.6666666666666714,4.440892098500626E-15 0.33333333333333215,1.7763568394002505E-15 0.6666666666666643,0.0 0.33333333333333215,0.33333333333333215 a58 a56 a278 INHIBITION s46 s37 0.33333333333333304,0.0 0.6666666666666643,0.0 a62 a53 INHIBITION s43 s40 0.3333333333333357,0.0 0.6666666666666679,-2.6645352591003757E-15 a59 a56 INHIBITION s43 s41 -0.0668527331484654,-0.34710656795333694 0.5905501176085775,0.0032292226831578397 a59 a57 STATE_TRANSITION s232 s232 0.3333333333333357,0.0 0.6666666666666679,-1.7763568394002505E-15 a282 a283 UNKNOWN_TRANSITION s181 s41 0.33333333333333215,8.881784197001252E-16 0.6666666666666643,0.0 a284 a57 STATE_TRANSITION s233 s233 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666679,-2.6645352591003757E-15 a285 a286 STATE_TRANSITION s234 s234 0.3333333333333339,0.0 0.6666666666666661,0.0 a287 a288 STATE_TRANSITION s224 s224 0.33333333333333337,5.773159728050814E-15 0.6666666666666669,1.0658141036401503E-14 a292 a291 STATE_TRANSITION s225 s225 0.33333333333333326,-8.881784197001252E-16 0.666666666666667,0.0 a289 a290 UNKNOWN_TRANSITION s234 s124 0.33333333333333215,8.881784197001252E-16 0.6666666666666679,-1.7763568394002505E-15 a288 a293 UNKNOWN_TRANSITION s225 s124 0.3333333333333339,0.0 0.666666666666667,3.552713678800501E-15 a290 a293 UNKNOWN_TRANSITION s224 s124 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666679,-1.7763568394002505E-15 a291 a293 HETERODIMER_ASSOCIATION s189,s188 s193 0.3333333333333286,3.552713678800501E-15 0.6666666666666643,0.0 0.3333333333333286,0.0 0.6666666666666643,7.105427357601002E-15 0.33333333333333215,1.7763568394002505E-15 0.6666666666666679,8.881784197001252E-16 0.3333333333333286,0.3333333333333357 a297 a296 a301 DISSOCIATION s193 s188,s235 0.33333333333333304,-7.105427357601002E-15 0.666666666666667,0.0 0.3333333333333304,4.440892098500626E-16 0.6666666666666643,4.440892098500626E-16 0.33333333333333215,8.881784197001252E-16 0.6666666666666661,8.881784197001252E-16 0.3333333333333339,0.3333333333333335 a301 a296 a298 STATE_TRANSITION s223 s223 0.33333333333333215,-2.220446049250313E-15 0.6666666666666643,-3.1086244689504383E-15 a303 a302 STATE_TRANSITION s237 s237 0.3333333333333357,2.220446049250313E-16 0.6666666666666643,4.440892098500626E-16 a306 a308 STATE_TRANSITION s241 s241 0.3333333333333357,-8.881784197001252E-16 0.666666666666675,-1.7763568394002505E-15 a309 a305 STATE_TRANSITION s238 s238 0.3333333333333357,1.3322676295501878E-15 0.6666666666666679,3.9968028886505635E-15 a310 a311 STATE_TRANSITION s239 s239 0.3333333333333339,-4.440892098500626E-16 0.6666666666666661,-4.440892098500626E-16 a312 a313 STATE_TRANSITION s240 s240 0.33333333333333215,0.0 0.6666666666666679,4.440892098500626E-16 a314 a315 TRANSPORT s240 s200 0.33333333333333326,0.0 0.6666666666666663,0.0 a315 a316 UNKNOWN_TRANSITION s200 s124 0.33333333333333304,0.0 0.666666666666667,4.440892098500626E-16 a316 a293 HETERODIMER_ASSOCIATION s4,s1 s203 0.33333333333333326,-4.163336342344337E-17 0.6666666666666667,-9.71445146547012E-17 0.33333333333333326,0.0 0.6666666666666667,-2.220446049250313E-16 0.33333333333333337,3.552713678800501E-15 0.6666666666666669,6.8833827526759706E-15 0.33333333333333326,0.33333333333333326 a5 a3 a320 HETERODIMER_ASSOCIATION s203,s142 s206 0.4102982635228012,0.06757269161127682 0.900353800813616,0.1675553336864795 0.296589973029575,0.09509506750227104 0.6182583303954158,0.1436235794140286 0.33333333333333304,-9.992007221626409E-16 0.666666666666667,-2.1094237467877974E-15 -1.9668303323750134,2.4944540893573817 a320 a193 a330 HETERODIMER_ASSOCIATION s4,s125 s208 0.3333333333333339,8.881784197001252E-16 0.666666666666667,0.0 0.3333333333333339,0.0 0.6666666666666661,0.0 0.3333333333333339,-2.7755575615628914E-16 0.6666666666666679,3.885780586188048E-16 0.33333333333333304,0.3333333333333339 a154 a153 a333 HETERODIMER_ASSOCIATION s208,s216 s209 0.3333333333333339,4.163336342344337E-16 0.666666666666667,4.163336342344337E-16 0.33333333333333304,0.0 0.6666666666666652,0.0 0.33333333333333304,-4.440892098500626E-16 0.6666666666666661,0.0 0.33333333333333304,0.33333333333333304 a333 a178 a339 HETERODIMER_ASSOCIATION s156,s155 s211 0.33333333333333215,-3.552713678800501E-15 0.6666666666666661,0.0 0.3333333333333357,3.552713678800501E-15 0.6666666666666714,3.552713678800501E-15 0.3333333333333286,-3.552713678800501E-15 0.6666666666666643,-3.552713678800501E-15 0.33333333333333215,0.3333333333333357 a228 a221 a342 STATE_TRANSITION s211 s214 0.3333333333333339,5.967448757360216E-16 0.6666666666666661,1.096345236817342E-15 a342 a235 a236 a350