<?xml version="1.0" encoding="UTF-8"?>
<!-- Terms and Conditions -->
<!-- 
Copyright (C) 2007 SRI International.  All Rights Reserved.
This file may be copied and redistributed freely, without advance
permission, provided that these notices are reproduced with each
copy.  Your use of the data herein is solely at your own risk.
The data is not, and is not supplied as, medical information.

THIS DATA IS PROVIDED "AS IS" AND WITHOUT ANY EXPRESS OR IMPLIED
WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES
OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. IN NO
EVENT SHALL SRI BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL,
SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT
LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF
USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND
ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,
OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT
OF THE USE OF THIS DATA, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH
DAMAGE.

The data herein were made in part with support under Grant Number
5 U01 DA 020830 from the National Institute on Drug Abuse at the
National Institutes of Health. 
-->

<!-- Created by SBML API 2.0(a17.0) -->
<sbml xmlns="http://www.sbml.org/sbml/level2" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" level="2" version="1">
<model id="Bupropion_degradation">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
<![CDATA[
Bupropion is a drug in the amino ketone class that was developed for use as an antidepressant. It is marketed as bupropion hydrochloride under the brand name Wellbutrin (GlaxoSmithKline). Its exact mechanism of action as an antidepressant is unknown. Bupropion has also been found to be useful in smoking cessation therapy, particularly in combination with nicotine replacement therapy and behavioral therapy. It is marketed for smoking cessation therapy as bupropion hydrochloride, sustained-release formulation, under the brand name Zyban (GlaxoSmithKline). It can block the reuptake of dopamine and norepinephrine in the brain and may be a brain nicotinic acetylcholine receptor antagonist, suggesting its use in smoking cessation therapy.######In humans given an oral dose of bupropion, radioimmunoassay indicated rapid absorption and appearance of the drug in plasma. Plasma levels fall as the drug is extensively metabolized in the liver. Approximately 80% of a dose of bupropion is excreted as metabolites in urine, with less than 1% excreted as unchanged bupropion. Bupropion is metabolized to basic and acidic metabolites in humans. Major basic metabolites include hydroxybupropion, and the amino alcohol isomers threohydrobupropion and erythrohydrobupropion. Two acidic metabolites, m-chlorobenzoic acid and m-chlorohippuric acid, have also been identified. Differences in bupropion metabolism between humans and animals have been described. Humans given an oral dose of 14C-bupropion excreted relatively more basic metabolites than rats, which excreted predominantly acidic metabolites. Human plasma contained relatively more hydroxybupropion than bupropion, while the opposite was true for rat plasma.######Hydroxybupropion is the main physiologically active metabolite in humans. The involvement of the cytochrome P450 isoform 2B6 in this hydroxylation reaction has been shown. The formation of threohydrobupropion and erythrohydrobupropion involves modification of the aminoketone bupropion to amino alcohols by ketone reduction. The concentration of erythrohydrobupropion in human plasma is low compared to that of the threohydrobupropion isomer. Glucuronide conjugates of threohydrobupropion and erythrohydrobupropion have been identified. In humans given an oral dose of 14C-bupropion, an average of 13% of the dose was excreted in urine as these glucuronides.######The formation of m-chlorobenzoic acid involves side chain cleavage, converting basic bupropion to an acidic metabolite. In humans given an oral dose of 14C-bupropion, only 0.3% of the dose was excreted in urine as m-chlorobenzoic acid. This metabolite is inactive. m-Chlorohippuric acid is the glycine conjugate of m-chlorobenzoic acid. In humans given an oral dose of 14C-bupropion, 22% of the dose was excreted in urine as m-chlorohippuric acid.;######PMID: 15081921, PMID: 10997944, PMID: 11454731,  PMID: 6406469, PMID: 12911050, PMID: 9378846
Medline=17073575
Medline=16815319
Medline=17009913
]]>
</body>
</html>
</notes>
<annotation>
<celldesigner:modelVersion>2.5</celldesigner:modelVersion>
<celldesigner:modelDisplay sizeX="800" sizeY="400"/>
<celldesigner:listOfCompartmentAliases/>
<celldesigner:listOfComplexSpeciesAliases/>
<celldesigner:listOfSpeciesAliases>
<celldesigner:speciesAlias id="sa1" species="s1">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="35.0" w="138.0" x="331.0" y="19.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="35.0" width="138.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa2" species="s2">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="34.0" w="151.0" x="21.0" y="199.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="34.0" width="151.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa3" species="s3">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="29.0" w="147.0" x="232.0" y="333.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="29.0" width="147.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa4" species="s4">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="31.0" w="166.0" x="412.0" y="199.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="31.0" width="166.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa5" species="s5">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="29.0" w="157.0" x="615.0" y="195.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="29.0" width="157.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa6" species="s6">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="30.0" w="146.0" x="623.0" y="330.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="30.0" width="146.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa7" species="s7">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="22.0" w="40.0" x="246.0" y="93.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="22.0" width="40.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa8" species="s8">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="19.0" w="65.0" x="193.0" y="135.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="19.0" width="65.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa9" species="s9">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="21.0" w="67.0" x="187.0" y="227.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="21.0" width="67.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa10" species="s10">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="18.0" w="51.0" x="216.0" y="284.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="18.0" width="51.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa11" species="s10">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="18.0" w="51.0" x="590.0" y="299.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="18.0" width="51.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa12" species="s11">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="24.0" w="71.0" x="593.0" y="231.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="24.0" width="71.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa16" species="s13">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="43.0" w="106.0" x="374.0" y="248.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="43.0" width="106.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
</celldesigner:listOfSpeciesAliases>
<celldesigner:listOfGroups/>
<celldesigner:listOfProteins>
<celldesigner:protein id="pr2" name="Cytochrome_br_P450 2B6" type="GENERIC"/>
</celldesigner:listOfProteins>
<celldesigner:listOfGenes/>
<celldesigner:listOfRNAs/>
<celldesigner:listOfAntisenseRNAs/>
<celldesigner:listOfBlockDiagrams/>
</annotation>
<listOfCompartments>
<compartment id="default"/>
</listOfCompartments>
<listOfSpecies>
<species compartment="default" id="s1" initialAmount="0.0" name="bupropion">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  bupropion
Synonym:  Synonym not specified
Accession:  S05801
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>bupropion</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s2" initialAmount="0.0" name="threohydrobupropion">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  threohydrobupropion
Synonym:  Synonym not specified
Accession:  S05800
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>threohydrobupropion</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s3" initialAmount="0.0" name="hydroxybupropion">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  hydroxybupropion
Synonym:  Synonym not specified
Accession:  S05795
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>hydroxybupropion</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s4" initialAmount="0.0" name="erythrohydrobupropion">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  erythrohydrobupropion
Synonym:  Synonym not specified
Accession:  S05794
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>erythrohydrobupropion</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s5" initialAmount="0.0" name="m-chlorobenzoate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  m-chlorobenzoate
Synonym:  Synonym not specified
Accession:  S05793
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>m-chlorobenzoate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s6" initialAmount="0.0" name="m-chlorohippurate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  m-chlorohippurate
Synonym:  Synonym not specified
Accession:  S05796
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>m-chlorohippurate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s7" initialAmount="0.0" name="O_sub_2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  O2
Synonym:  Synonym not specified
Accession:  S05799
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>O_sub_2</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s8" initialAmount="0.0" name="NADPH">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NADPH
Synonym:  Synonym not specified
Accession:  S05791
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NADPH</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s9" initialAmount="0.0" name="NADP_super__plus_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NADP+
Synonym:  Synonym not specified
Accession:  S05798
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NADP_super__plus_</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s10" initialAmount="0.0" name="H_sub_2_endsub_O">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  H2O
Synonym:  Synonym not specified
Accession:  S05797
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>H_sub_2_endsub_O</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s11" initialAmount="0.0" name="glycine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  glycine
Synonym:  Synonym not specified
Accession:  S05792
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>glycine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s13" initialAmount="0.0" name="Cytochrome_br_P450 2B6">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Cytochrome P450 2B6
Synonym:  CYP2B6,Cytochrome P450 2B6/bupropion hydroxylase,cytochrome P450, family 2, subfamily B, polypeptide 6
Accession:  P05742
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions >
<celldesigner:catalyzed reaction="re2"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="re1" reversible="false">
<annotation>
<celldesigner:reactionType >STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa1" species="s1">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa2" species="s2">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints >0.8401971989817019,0.29725222645979527</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0" />
</annotation>
<listOfReactants>
<speciesReference species="s1">
<annotation>
<celldesigner:alias >sa1</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s2">
<annotation>
<celldesigner:alias >sa2</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re2" reversible="false">
<annotation>
<celldesigner:reactionType >STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa1" species="s1">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa3" species="s3">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks >
<celldesigner:reactantLink alias="sa8" reactant="s8" targetLineIndex="-1,1">
<celldesigner:linkAnchor position="ESE"/>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:reactantLink>
<celldesigner:reactantLink alias="sa7" reactant="s7" targetLineIndex="-1,1">
<celldesigner:linkAnchor position="SSE"/>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks >
<celldesigner:productLink alias="sa9" product="s9" targetLineIndex="-1,1">
<celldesigner:linkAnchor position="ESE"/>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:productLink>
<celldesigner:productLink alias="sa10" product="s10" targetLineIndex="-1,1">
<celldesigner:linkAnchor position="ENE"/>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:productLink>
</celldesigner:listOfProductLinks>
<celldesigner:connectScheme connectPolicy="direct" >
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints >0.37019093700825206,0.21680974387828966 0.7085497245412596,0.09716031583847862</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0" />
<celldesigner:listOfModification >
<celldesigner:modification aliases="sa16" modifiers="s13" targetLineIndex="-1,1" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget alias="sa16" species="s13">
<celldesigner:linkAnchor position="W"/>
</celldesigner:linkTarget>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s1">
<annotation>
<celldesigner:alias >sa1</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s8">
<annotation>
<celldesigner:alias >sa8</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s7">
<annotation>
<celldesigner:alias >sa7</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s3">
<annotation>
<celldesigner:alias >sa3</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s9">
<annotation>
<celldesigner:alias >sa9</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s10">
<annotation>
<celldesigner:alias >sa10</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s13">
<annotation>
<celldesigner:alias >sa16</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re3" reversible="false">
<annotation>
<celldesigner:reactionType >STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa1" species="s1">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa4" species="s4">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints >0.5299018157542359,-0.22445634407138604</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0" />
</annotation>
<listOfReactants>
<speciesReference species="s1">
<annotation>
<celldesigner:alias >sa1</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s4">
<annotation>
<celldesigner:alias >sa4</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re4" reversible="false">
<annotation>
<celldesigner:reactionType >STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa1" species="s1">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa5" species="s5">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints >0.80930668864024,-0.31311878136524773</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0" />
</annotation>
<listOfReactants>
<speciesReference species="s1">
<annotation>
<celldesigner:alias >sa1</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s5">
<annotation>
<celldesigner:alias >sa5</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re5" reversible="false">
<annotation>
<celldesigner:reactionType >STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa5" species="s5">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa6" species="s6">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks >
<celldesigner:reactantLink alias="sa12" reactant="s11" targetLineIndex="-1,1">
<celldesigner:linkAnchor position="ENE"/>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks >
<celldesigner:productLink alias="sa11" product="s10" targetLineIndex="-1,1">
<celldesigner:linkAnchor position="E"/>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:productLink>
</celldesigner:listOfProductLinks>
<celldesigner:connectScheme connectPolicy="direct" >
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints >0.20371811692499264,8.881784197001252E-16 0.7602348284373677,-8.881784197001252E-16</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0" />
</annotation>
<listOfReactants>
<speciesReference species="s5">
<annotation>
<celldesigner:alias >sa5</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s11">
<annotation>
<celldesigner:alias >sa12</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s6">
<annotation>
<celldesigner:alias >sa6</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s10">
<annotation>
<celldesigner:alias >sa11</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
</listOfReactions>
</model>
</sbml>


