2.3 SQUARE SQUARE SQUARE SQUARE_CLOSEUP_SOUTH SQUARE SQUARE SQUARE inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive Endoplasmic Reticulum Secretory Vesicle Parvocellular cells in PVN (also: preoptic areas, olfactory bulbs, central amyglada, layer 2/3 neocortex etc) Corticotrophs (cells in anterior pituitary) nucleus endoplasmic reticulum Long Name: GDP Synonym: Synonym not specified Accession: S04768 inside SIMPLE_MOLECULE GDP Long Name: GTP Synonym: Synonym not specified Accession: S04767 inside SIMPLE_MOLECULE GTP Long Name: Long name not specified Synonym: Synonym not specified Accession: U05152 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S04767##;G-Protein#PROTEIN#G-Protein#P04458## inside SIMPLE_MOLECULE GTP PROTEIN p8 Long Name: SNARE COMPLEX Synonym: Synonym not specified Accession: P04457 transmembrane PROTEIN p11 Long Name: ACTH Synonym: Synonym not specified Accession: P04453 inside PROTEIN p5 Long Name: Corticotropin-releasing factor Synonym: Synonym not specified Accession: P04454 inside PROTEIN p2 Long Name: Corticotropin-releasing factor Synonym: Synonym not specified Accession: P04454 inside PROTEIN p2 Long Name: Pro Corticotropin-releasing factor Synonym: Synonym not specified Accession: P04456 inside PROTEIN p1 Long Name: Stress Synonym: Synonym not specified Accession: U05157 inside UNKNOWN Stress Long Name: Long name not specified Synonym: Synonym not specified Accession: U05150 Heterodimer Member Info: CRHR1#PROTEIN#CRHR1#P04451##;G-Protein#PROTEIN#G-Protein#P04458##;GDP#SIMPLE_MOLECULE#GDP#S04768## transmembrane SIMPLE_MOLECULE GDP PROTEIN p8 PROTEIN p3 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05154 Heterodimer Member Info: CRHR1#PROTEIN#CRHR1#P04451##;CRF#PROTEIN#Corticotropin-releasing factor#P04454##;G-Protein#PROTEIN#G-Protein#P04458##;GDP#SIMPLE_MOLECULE#GDP#S04768## transmembrane SIMPLE_MOLECULE GDP PROTEIN p8 PROTEIN p3 PROTEIN p2 Long Name: type 1 plasma membrane receptors Synonym: Synonym not specified Accession: U05151 Heterodimer Member Info: CRHR1#PROTEIN#CRHR1#P04451##;CRF#PROTEIN#Corticotropin-releasing factor#P04454## transmembrane PROTEIN p3 PROTEIN p2 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05153 Heterodimer Member Info: Ca2+#ION#Ca2+#U05155##;SNARE COMPLEX#PROTEIN#SNARE COMPLEX#P04457## transmembrane ION Ca_super_2+ PROTEIN p11 Long Name: beta-endorphin Synonym: Synonym not specified Accession: P04455 inside PROTEIN p12 Long Name: ACTH Synonym: Synonym not specified Accession: P04453 inside PROTEIN p5 Long Name: beta-endorphin Synonym: Synonym not specified Accession: P04455 inside PROTEIN p12 Long Name: proopiomelanocortin Synonym: LIPOTROPIN, INCLUDED,MELANOCYTE-STIMULATING HORMONE, INCLUDED,MELANOTROPIN, INCLUDED,POC,PRO-ACTH-ENDORPHIN Accession: G04671 inside RNA proopiomelanocortin Long Name: proopiomelanocortin Synonym: LIPOTROPIN, INCLUDED,MELANOCYTE-STIMULATING HORMONE, INCLUDED,MELANOTROPIN, INCLUDED,POC,POMC,PRO-ACTH-ENDORPHIN Accession: P04452 inside PROTEIN p13 Long Name: pain reduction Synonym: Synonym not specified Accession: U05158 inside PHENOTYPE pain reduction Long Name: release of glutocorticoids and epinephrine Synonym: Synonym not specified Accession: U05156 inside PHENOTYPE release of glutocorticoids and epinephrine UNKNOWN_TRANSITION s1 s28 0.33333333333333326,2.498001805406602E-16 0.6666666666666665,4.996003610813204E-16 a1 a35 TRANSPORT s28 s2 0.20935732417113573,-0.19463412594131402 0.7982302942998896,-0.5498517859151928 a35 a2 a34 a49 HETERODIMER_ASSOCIATION s2,s24 s26 0.3333333333333337,0.0 0.6666666666666663,0.0 0.3333333333333339,0.0 0.6666666666666661,-3.552713678800501E-15 0.3333333333333335,0.0 0.6666666666666667,0.0 -0.5606634197647082,0.7551017493773848 a2 a37 a40 DISSOCIATION s26 s27,s10 0.3333333333333335,0.0 0.6666666666666667,4.440892098500626E-16 0.3333333333333339,-4.440892098500626E-16 0.666666666666667,-4.440892098500626E-16 0.3333333333333337,0.0 0.6666666666666665,0.0 0.3706872046058547,0.3427676192062288 a40 a7 a41 a11 a6 TRANSPORT s55 s53 0.3333333333333328,0.0 0.6666666666666667,4.440892098500626E-16 a61 a62 a60 TRANSPORT s34 s54 0.3333333333333335,-2.220446049250313E-16 0.666666666666667,0.0 a46 a63 a60 TRANSLATIONAL_ACTIVATION s61 s62 0.3333333333333335,-4.440892098500626E-16 0.6666666666666667,0.0 a66 a67 DISSOCIATION s62 s55,s34 0.33333333333333437,0.0 0.6666666666666674,0.0 0.33333333333333304,0.0 0.6666666666666665,1.7763568394002505E-15 0.3333333333333348,0.0 0.666666666666667,0.0 0.3333333333333339,0.3333333333333339 a67 a61 a46 KNOWN_TRANSITION_OMITTED s53 s63 0.3333333333333328,1.7763568394002505E-15 0.6666666666666663,3.552713678800501E-15 a62 a68 KNOWN_TRANSITION_OMITTED s54 s64 0.33333333333333215,1.7763568394002505E-15 0.6666666666666661,1.7763568394002505E-15 a63 a69 TRANSCRIPTIONAL_ACTIVATION s10 s61 0.33333333333333304,0.0 0.666666666666667,0.0 a11 a66