<?xml version="1.0" encoding="UTF-8"?>
<!-- Terms and Conditions -->
<!-- 
Copyright (C)) 2005 Applied Biosystems.  
This file may be copied and redistributed freely, without advance permission, 
provided that this Copyright statement is reproduced with each copy.  
 
LIMITATION OF WARRANTY 
NOTHING IN THIS AGREEMENT WILL BE CONSTRUED AS A REPRESENTATION MADE OR 
WARRANTY GIVEN BY APPLIED BIOSYSTEMS OR ANY THIRD PARTY THAT THE USE OF 
DATA PROVIDED HEREUNDER WILL NOT INFRINGE ANY PATENT, COPYRIGHT, TRADEMARK 
OR OTHER RIGHTS OF ANY THIRD PARTY. DATA IS PROVIDED "AS IS" WITHOUT 
WARRANTY OF ANY KIND WHATSOEVER, EXPRESS OR IMPLIED, INCLUDING IMPLIED 
WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. APPLIED 
BIOSYSTEMS MAKES NO WARRANTY THAT ITS DATA DOES NOT CONTAIN ERRORS.
-->

<!-- Created by SBML API 2.0(a17.0) -->
<sbml level="2" version="1" xmlns="http://www.sbml.org/sbml/level2" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner">
<model id="D1_slash_D5_space_dopamine_space_receptor_space_mediated_space_sigaling_space_pathway">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
<![CDATA[
No pathway definition
]]>
</body>
</html>
</notes>
<annotation>
<celldesigner:modelVersion>2.3</celldesigner:modelVersion>
<celldesigner:modelDisplay sizeX="750" sizeY="800"/>
<celldesigner:listOfCompartmentAliases>
<celldesigner:compartmentAlias compartment="c1" id="ca1">
<celldesigner:class>SQUARE_CLOSEUP_NORTHEAST</celldesigner:class>
<celldesigner:point x="586.0" y="276.0"/>
<celldesigner:doubleLine innerWidth="1.0" outerWidth="2.0" thickness="12.0"/>
<celldesigner:paint color="ffcccc00" scheme="Color"/>
</celldesigner:compartmentAlias>
<celldesigner:compartmentAlias compartment="c2" id="ca2">
<celldesigner:class>SQUARE_CLOSEUP_SOUTH</celldesigner:class>
<celldesigner:point x="693.0" y="116.0"/>
<celldesigner:doubleLine innerWidth="1.0" outerWidth="2.0" thickness="12.0"/>
<celldesigner:paint color="ffcccc00" scheme="Color"/>
</celldesigner:compartmentAlias>
<celldesigner:compartmentAlias compartment="c3" id="ca3">
<celldesigner:class>OVAL</celldesigner:class>
<celldesigner:bounds h="295.0" w="159.0" x="414.0" y="363.0"/>
<celldesigner:doubleLine innerWidth="1.0" outerWidth="2.0" thickness="12.0"/>
<celldesigner:paint color="ffcccc00" scheme="Color"/>
</celldesigner:compartmentAlias>
<celldesigner:compartmentAlias compartment="c3" id="ca5">
<celldesigner:class>OVAL</celldesigner:class>
<celldesigner:bounds h="99.0" w="208.0" x="398.0" y="9.0"/>
<celldesigner:doubleLine innerWidth="1.0" outerWidth="2.0" thickness="12.0"/>
<celldesigner:paint color="ffcccc00" scheme="Color"/>
</celldesigner:compartmentAlias>
</celldesigner:listOfCompartmentAliases>
<celldesigner:listOfSpeciesAliases>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a2" species="s17">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="33.0" w="46.0" x="36.25" y="383.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a4" species="s18">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="38.0" w="40.0" x="188.25" y="409.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a5" species="s5">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="36.0" w="50.0" x="104.25" y="500.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a6" species="s19">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="26.0" w="29.0" x="230.75" y="345.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a7" species="s7">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="24.0" w="27.0" x="277.75" y="345.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a9" species="s18">
<celldesigner:activity>active</celldesigner:activity>
<celldesigner:bounds h="38.0" w="40.0" x="185.75" y="506.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a10" species="s17">
<celldesigner:activity>active</celldesigner:activity>
<celldesigner:bounds h="32.0" w="43.0" x="38.25" y="496.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a15" species="s11">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="36.0" w="50.0" x="106.25" y="411.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca5" id="a18" species="s46">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="47.0" w="94.0" x="457.25" y="92.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a28" species="s28">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:listOfInnerAliases>
<celldesigner:innerAlias heterodimerEntry="inner0">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="26.0" w="29.0" x="518.5335953963374" y="321.875"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:innerAlias>
<celldesigner:innerAlias heterodimerEntry="inner1">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="20.0" w="67.0" x="484.17195770394164" y="304.875"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:innerAlias>
<celldesigner:innerAlias heterodimerEntry="inner2">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="54.0" w="72.0" x="474.96155755287566" y="252.375"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffcc" scheme="Color"/>
</celldesigner:innerAlias>
</celldesigner:listOfInnerAliases>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a32" species="s30">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="70.0" x="389.0" y="205.5"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a35" species="s32">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:listOfInnerAliases>
<celldesigner:innerAlias heterodimerEntry="inner0">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="54.0" w="72.0" x="68.16198095383379" y="256.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffcc" scheme="Color"/>
</celldesigner:innerAlias>
<celldesigner:innerAlias heterodimerEntry="inner1">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="70.0" x="67.83801904616621" y="241.75"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:innerAlias>
</celldesigner:listOfInnerAliases>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a43" species="s38">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:listOfInnerAliases>
<celldesigner:innerAlias heterodimerEntry="inner0">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="26.0" w="29.0" x="307.542456538592" y="324.75"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:innerAlias>
<celldesigner:innerAlias heterodimerEntry="inner1">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="20.0" w="67.0" x="273.1808188461973" y="307.75"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:innerAlias>
<celldesigner:innerAlias heterodimerEntry="inner2">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="54.0" w="72.0" x="255.03628633031258" y="256.25"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffcc" scheme="Color"/>
</celldesigner:innerAlias>
<celldesigner:innerAlias heterodimerEntry="inner3">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="70.0" x="256.6082987760884" y="241.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:innerAlias>
</celldesigner:listOfInnerAliases>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca5" id="a45" species="s42">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="70.0" x="465.0" y="39.5"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a46" species="s43">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="37.0" w="128.0" x="593.0" y="746.5"/>
<celldesigner:singleLine width="0.0"/>
<celldesigner:paint color="7fcccccc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a48" species="s45">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="70.0" x="621.0" y="649.5"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca3" id="a49" species="s46">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="47.0" w="94.0" x="521.0" y="416.5"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca3" id="a50" species="s46">
<celldesigner:activity>active</celldesigner:activity>
<celldesigner:bounds h="47.0" w="94.0" x="531.0" y="553.5"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca3" id="a51" species="s47">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="70.0" x="446.0" y="542.5"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a53" species="s51">
<celldesigner:activity>active</celldesigner:activity>
<celldesigner:bounds h="25.0" w="72.0" x="156.0" y="603.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a54" species="s52">
<celldesigner:activity>active</celldesigner:activity>
<celldesigner:bounds h="25.0" w="143.0" x="252.0" y="525.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a55" species="s51">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="72.0" x="74.0" y="548.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a56" species="s52">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="143.0" x="252.5" y="678.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a60" species="s54">
<celldesigner:activity>active</celldesigner:activity>
<celldesigner:listOfInnerAliases>
<celldesigner:innerAlias heterodimerEntry="inner0">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="24.0" w="27.0" x="140.5" y="357.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccff66" scheme="Color"/>
</celldesigner:innerAlias>
<celldesigner:innerAlias heterodimerEntry="inner1">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="20.0" w="67.0" x="103.43808064927148" y="340.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:innerAlias>
</celldesigner:listOfInnerAliases>
</celldesigner:speciesAlias>
</celldesigner:listOfSpeciesAliases>
<celldesigner:listOfGroups/>
<celldesigner:listOfProteins>
<celldesigner:protein id="p11" name="G-protein" type="GENERIC"/>
<celldesigner:protein id="p5" name="AC" type="GENERIC"/>
<celldesigner:protein id="p1" name="D1/D5" type="RECEPTOR"/>
<celldesigner:protein id="p6" name="PKA" type="GENERIC"/>
<celldesigner:protein id="p10" name="SNARE Complex" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="5.84" id="rs1"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p2" name="DARPP-32" type="GENERIC"/>
<celldesigner:protein id="p3" name="Protein Phosphatase-1" type="GENERIC"/>
</celldesigner:listOfProteins>
<celldesigner:listOfBlockDiagrams/>
</annotation>
<listOfCompartments>
<compartment id="default"/>
<compartment id="c1" name="Caudate Putamen (also in nucleus accumbens and olfactory tubercle)" outside="default">
<annotation>
<celldesigner:name>Caudate Putamen (also in nucleus accumbens and olfactory tubercle)</celldesigner:name>
</annotation>
</compartment>
<compartment id="c2" name="Midbrain DA neuron (substantia niagra)" outside="default">
<annotation>
<celldesigner:name>Midbrain DA neuron (substantia niagra)</celldesigner:name>
</annotation>
</compartment>
<compartment id="c3" name="secretory vesicle" outside="c1">
<annotation>
<celldesigner:name>secretory vesicle</celldesigner:name>
</annotation>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species compartment="c1" id="s5" name="cAMP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  cAMP
Synonym:  Synonym not specified
Accession:  S04770
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cAMP</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re7"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s7" name="GTP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S04772
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s11" name="ATP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S04769
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s17" name="AC">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  AC
Synonym:  adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase
Accession:  P04465
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re1"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s18" name="PKA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  PKA
Synonym:  protein kinase A
Accession:  P04462
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re13"/>
<celldesigner:catalyzed reaction="re19"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s19" name="GDP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GDP
Synonym:  Synonym not specified
Accession:  S04774
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s28" name="Complex(GDP/G-protein/D1/D5)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05169
Heterodimer Member Info:  G-protein#PROTEIN#G-protein#P04459##;D1/D5#PROTEIN#D1/D5#P04463#D1|D5#;GDP#SIMPLE_MOLECULE#GDP#S04774##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="default" id="s30" name="Dopamine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Dopamine
Synonym:  Synonym not specified
Accession:  S04771
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Dopamine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s32" name="Complex(D1/D5/Dopamine)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05170
Heterodimer Member Info:  Dopamine#SIMPLE_MOLECULE#Dopamine#S04771##;D1/D5#PROTEIN#D1/D5#P04463#D1|D5#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Dopamine</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" id="s38" name="Complex(GDP/G-protein/D1/D5/Dopamine)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05172
Heterodimer Member Info:  G-protein#PROTEIN#G-protein#P04459##;Dopamine#SIMPLE_MOLECULE#Dopamine#S04771##;D1/D5#PROTEIN#D1/D5#P04463#D1|D5#;GDP#SIMPLE_MOLECULE#GDP#S04774##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Dopamine</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c3" id="s42" name="Dopamine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Dopamine
Synonym:  Synonym not specified
Accession:  S04771
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Dopamine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s43" name="fine motor control">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  fine motor control
Synonym:  Synonym not specified
Accession:  U05173
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>UNKNOWN</celldesigner:class>
<celldesigner:name>fine motor control</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s45" name="ACh">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ACh
Synonym:  Synonym not specified
Accession:  S04773
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ACh</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s46" name="SNARE Complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  SNARE Complex
Synonym:  Synonym not specified
Accession:  P04461
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re14"/>
<celldesigner:catalyzed reaction="re16"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" id="s47" name="ACh">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ACh
Synonym:  Synonym not specified
Accession:  S04773
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ACh</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s51" name="DARPP-32">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  DARPP-32
Synonym:  Synonym not specified
Accession:  P04464
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re20"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s52" name="Protein Phosphatase-1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Protein Phosphatase-1
Synonym:  Synonym not specified
Accession:  P04460
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re13"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s54" name="Complex(GTP/G-protein)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05171
Heterodimer Member Info:  G-protein#PROTEIN#G-protein#P04459##;GTP#SIMPLE_MOLECULE#GTP#S04772##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re8"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="re1" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s11</celldesigner:baseReactants>
<celldesigner:baseProducts>s5</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,-4.440892098500626E-16 0.6666666666666679,-4.440892098500626E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a10" editPoints="0.33333333333333304,0.0 0.6666666666666661,0.0" modifiers="s17" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s11">
<annotation>
<celldesigner:alias>a15</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s5">
<annotation>
<celldesigner:alias>a5</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s17">
<annotation>
<celldesigner:alias>a10</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re7" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s18</celldesigner:baseReactants>
<celldesigner:baseProducts>s18</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,0.0 0.666666666666667,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a5" editPoints="0.3333333333333326,-8.881784197001252E-16 0.6666666666666656,-8.881784197001252E-16" modifiers="s5" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s18">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s18">
<annotation>
<celldesigner:alias>a9</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s5">
<annotation>
<celldesigner:alias>a5</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re8" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s17</celldesigner:baseReactants>
<celldesigner:baseProducts>s17</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,8.881784197001252E-16 0.6666666666666661,8.881784197001252E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a60" editPoints="0.3333333333333335,-4.440892098500626E-16 0.666666666666667,0.0" modifiers="s54" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s17">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s17">
<annotation>
<celldesigner:alias>a10</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s54">
<annotation>
<celldesigner:alias>a60</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re10" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s30,s28</celldesigner:baseReactants>
<celldesigner:baseProducts>s38</celldesigner:baseProducts>
<celldesigner:offset x="1.0" y="-10.0"/>
<celldesigner:editPoints>0.33333333333333304,-4.440892098500626E-16 0.666666666666667,-8.881784197001252E-16 0.33333333333333304,0.0 0.666666666666667,8.881784197001252E-16 0.33333333333333304,-1.1102230246251565E-16 0.6666666666666661,-5.551115123125783E-16 0.3333333333333337,0.3333333333333335</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s30">
<annotation>
<celldesigner:alias>a32</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s28">
<annotation>
<celldesigner:alias>a28</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s38">
<annotation>
<celldesigner:alias>a43</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re13" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s46</celldesigner:baseReactants>
<celldesigner:baseProducts>s46</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,0.0 0.6666666666666665,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a9" editPoints="0.20421250923833545,-0.10091525449498806 0.6859724221189554,-0.0768841037095429" modifiers="s18" targetLineIndex="-1,1" type="UNKNOWN_CATALYSIS"/>
<celldesigner:modification aliases="a54" editPoints="0.33333333333333326,0.0 0.6666666666666663,4.440892098500626E-16" modifiers="s52" targetLineIndex="-1,1" type="UNKNOWN_INHIBITION"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s46">
<annotation>
<celldesigner:alias>a49</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s46">
<annotation>
<celldesigner:alias>a50</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s18">
<annotation>
<celldesigner:alias>a9</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference species="s52">
<annotation>
<celldesigner:alias>a54</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re14" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>s47</celldesigner:baseReactants>
<celldesigner:baseProducts>s45</celldesigner:baseProducts>
<celldesigner:offset x="-4.0" y="18.0"/>
<celldesigner:editPoints>0.27092385898132054,-0.03807075385292902 0.8089675815004176,-0.3639274595120421</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a50" editPoints="0.3333333333333339,0.0 0.6666666666666661,1.7763568394002505E-15" modifiers="s46" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s47">
<annotation>
<celldesigner:alias>a51</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s45">
<annotation>
<celldesigner:alias>a48</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s46">
<annotation>
<celldesigner:alias>a50</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re15" reversible="false">
<annotation>
<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
<celldesigner:baseReactants>s45</celldesigner:baseReactants>
<celldesigner:baseProducts>s43</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,0.0 0.6666666666666665,8.881784197001252E-16</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s45">
<annotation>
<celldesigner:alias>a48</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s43">
<annotation>
<celldesigner:alias>a46</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re16" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>s42</celldesigner:baseReactants>
<celldesigner:baseProducts>s30</celldesigner:baseProducts>
<celldesigner:editPoints>0.2587004888646247,-0.16301384449744116 0.6175661110951474,-0.3225906501048774</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a18" editPoints="0.3333333333333339,-1.7763568394002505E-15 0.6666666666666679,0.0" modifiers="s46" targetLineIndex="-1,0" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s42">
<annotation>
<celldesigner:alias>a45</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s30">
<annotation>
<celldesigner:alias>a32</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s46">
<annotation>
<celldesigner:alias>a18</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re19" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s51</celldesigner:baseReactants>
<celldesigner:baseProducts>s51</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333339,8.881784197001252E-16 0.6666666666666674,8.881784197001252E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a9" editPoints="0.15067658986771448,-0.4234780273933545 0.6229738863504739,-0.16794113324091064" modifiers="s18" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s51">
<annotation>
<celldesigner:alias>a55</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s51">
<annotation>
<celldesigner:alias>a53</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s18">
<annotation>
<celldesigner:alias>a9</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re20" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s52</celldesigner:baseReactants>
<celldesigner:baseProducts>s52</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,0.0 0.6666666666666656,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a53" editPoints="0.33333333333333304,0.0 0.666666666666667,0.0" modifiers="s51" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s52">
<annotation>
<celldesigner:alias>a56</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s52">
<annotation>
<celldesigner:alias>a54</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s51">
<annotation>
<celldesigner:alias>a53</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re21" reversible="false">
<annotation>
<celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s38</celldesigner:baseReactants>
<celldesigner:baseProducts>s32,s54</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a7" reactant="s7" targetLineIndex="0,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a6" product="s19" targetLineIndex="0,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333335,0.0 0.666666666666667,4.440892098500626E-16 0.33333333333333304,-4.440892098500626E-16 0.666666666666667,-8.881784197001252E-16 0.33333333333333326,-8.881784197001252E-16 0.6666666666666667,-8.881784197001252E-16 0.33333333333333304,0.3333333333333335</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s38">
<annotation>
<celldesigner:alias>a43</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s7">
<annotation>
<celldesigner:alias>a7</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s32">
<annotation>
<celldesigner:alias>a35</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s54">
<annotation>
<celldesigner:alias>a60</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s19">
<annotation>
<celldesigner:alias>a6</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
</listOfReactions>
</model>
</sbml>

