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Synonym:  Synonym not specified
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<body>
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05191
Heterodimer Member Info:  GPCR (s)#PROTEIN#GPCR (s)#P04473##;G-Protein (s)#PROTEIN#G-Protein (s)#P04474##;GDP#SIMPLE_MOLECULE#GDP#S04787##
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<notes>
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<!--Notes by CellDesigner-->
<body>
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Synonym:  Synonym not specified
Accession:  U05190
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<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" id="s28" name="Complex(GTP/G-Protein (i))">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05189
Heterodimer Member Info:  GTP#SIMPLE_MOLECULE#GTP#S04786##;G-Protein (i)#PROTEIN#G-Protein (i)#P04478##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re2"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s29" name="AC">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  AC
Synonym:  adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase
Accession:  P04479
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>innerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s5" name="PKA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CREB
Synonym:  Synonym not specified
Accession:  P04472
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s30" name="CREB">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CREB
Synonym:  Synonym not specified
Accession:  P04472
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s31" name="PKA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  PKA
Synonym:  protein kinase A
Accession:  P04476
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re4"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s33" name="Protoenkephalin mRNA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Protoenkephalin mRNA
Synonym:  Synonym not specified
Accession:  G04672
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:name>Protoenkephalin mRNA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s34" name="Enkephalin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Enkephalin
Synonym:  Synonym not specified
Accession:  P04475
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s35" name="Complex(CREB/Protoenkephalin)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05193
Heterodimer Member Info:  CREB#PROTEIN#CREB#P04472##;Protoenkephalin#GENE#Protoenkephalin#G04673##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>Protoenkephalin</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" id="s36" name="Protoenkephalin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Protoenkephalin
Synonym:  Synonym not specified
Accession:  G04673
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>Protoenkephalin</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s37" name="Pain relief_br_Analgesia">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Pain relief Analgesia
Synonym:  Synonym not specified
Accession:  U05195
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Pain relief_br_Analgesia</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s38" name="Bind to opioid receptors">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Bind to opioid receptors
Synonym:  Synonym not specified
Accession:  U05194
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Bind to opioid receptors</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
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<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s9</celldesigner:baseReactants>
<celldesigner:baseProducts>s10</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333339,-4.996003610813204E-16 0.6666666666666679,3.885780586188048E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
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</celldesigner:listOfModification>
</annotation>
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<speciesReference species="s9">
<annotation>
<celldesigner:alias>a11</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s10">
<annotation>
<celldesigner:alias>a12</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s4">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s29</celldesigner:baseReactants>
<celldesigner:baseProducts>s4</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,-8.881784197001252E-16 0.666666666666667,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
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</celldesigner:listOfModification>
</annotation>
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<speciesReference species="s29">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s2">
<annotation>
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</annotation>
</modifierSpeciesReference>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
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<celldesigner:baseProducts>s30</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333215,8.881784197001252E-16 0.6666666666666661,0.0</celldesigner:editPoints>
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</celldesigner:listOfModification>
</annotation>
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<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
<celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType>
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<celldesigner:baseProducts>s18,s28</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a37" product="s3" targetLineIndex="0,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333339,-4.440892098500626E-16 0.6666666666666679,-6.661338147750939E-16 0.33333333333333215,0.0 0.6666666666666661,-1.7763568394002505E-15 0.3333333333333339,8.881784197001252E-16 0.666666666666667,0.0 0.3333333333333339,0.3333333333333333</celldesigner:editPoints>
</annotation>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re6" reversible="false">
<annotation>
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<celldesigner:baseProducts>s14,s2</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a3" product="s3" targetLineIndex="0,2"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333335,-3.3306690738754696E-16 0.6666666666666667,-5.551115123125783E-16 0.3333333333333333,-8.881784197001252E-16 0.666666666666667,0.0 0.3333333333333335,0.0 0.6666666666666674,-2.220446049250313E-16 0.33333333333333326,0.33333333333333326</celldesigner:editPoints>
</annotation>
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<annotation>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s3">
<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re7" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:baseProducts>s31</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,4.440892098500626E-16 0.6666666666666652,8.881784197001252E-16</celldesigner:editPoints>
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</annotation>
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<annotation>
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</speciesReference>
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<listOfProducts>
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<annotation>
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<annotation>
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</modifierSpeciesReference>
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<annotation>
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<celldesigner:offset x="3.0" y="5.0"/>
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</annotation>
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<annotation>
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</speciesReference>
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<annotation>
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</speciesReference>
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<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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<annotation>
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<annotation>
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<annotation>
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<annotation>
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</annotation>
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<annotation>
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<annotation>
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<annotation>
<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
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</model>
</sbml>

