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<![CDATA[
The main pathway for the degradation of fructose in the liver is via glycolysis.  Before it can enter glycolysis, however, fructose has to unergo a series of enzymatic catalysis reactions, comprising a major part of fructose metabolism pathway.  Galactose is also metabolized in the liver.  The entry of galactose into glycolysis is mediated by an epimerization reaction of galactose 1-phosphate.
free text=Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal
free text=Biochemistry by Voet and Voet
free text=Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p26</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r41"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s85" initialAmount="0.0" name="Ketohexokinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ketohexokinase
Synonym:  Synonym not specified
Accession:  P02963
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p27</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r44"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s87" initialAmount="0.0" name="Fructose bisphosphate_br_aldolase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Fructose bisphosphate aldolase
Synonym:  Synonym not specified
Accession:  P02959
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p28</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r48"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s89" initialAmount="0.0" name="Aldehyde_br_reductase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Aldehyde reductase
Synonym:  Synonym not specified
Accession:  P02961
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p29</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r46"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c2" id="s90" initialAmount="0.0" name="Dihydroxyacetone 3-P">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Dihydroxyacetone 3-P
Synonym:  Synonym not specified
Accession:  S03654
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Dihydroxyacetone 3-P</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s42" initialAmount="0.0" name="NADH + H_super_+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NADH + H+
Synonym:  Synonym not specified
Accession:  S03644
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NADH + H_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s92" initialAmount="0.0" name="NAD_super_+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NAD+
Synonym:  Synonym not specified
Accession:  S03648
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NAD_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s94" initialAmount="0.0" name="Triokinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Triokinase
Synonym:  Triose kinase
Accession:  P02962
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p30</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r49"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s96" initialAmount="0.0" name="ADP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ADP
Synonym:  Synonym not specified
Accession:  S03661
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ADP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s100" initialAmount="0.0" name="Galactose">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Galactose
Synonym:  Synonym not specified
Accession:  S03647
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Galactose</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s101" initialAmount="0.0" name="Galactose 1-phosphate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Galactose 1-phosphate
Synonym:  Synonym not specified
Accession:  S03650
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Galactose 1-phosphate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s102" initialAmount="0.0" name="Glucose 1-phosphate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Glucose 1-phosphate
Synonym:  Synonym not specified
Accession:  S03653
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Glucose 1-phosphate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s107" initialAmount="0.0" name="UDP Galactose">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  UDP Galactose
Synonym:  Synonym not specified
Accession:  S03652
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>UDP Galactose</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s108" initialAmount="0.0" name="UDP Glucose">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  UDP Glucose
Synonym:  Synonym not specified
Accession:  S03656
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>UDP Glucose</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s111" initialAmount="0.0" name="Galactokinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Galactokinase
Synonym:  Synonym not specified
Accession:  P02960
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p31</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s114" initialAmount="0.0" name="Hexose 1-P_br_uridyltransferase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Hexose 1-P uridyltransferase
Synonym:  Synonym not specified
Accession:  P02964
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p33</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r51"/>
<celldesigner:catalyzed reaction="r53"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s115" initialAmount="0.0" name="UDP Glucose_br_4 epimerase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  UDP Glucose 4 epimerase
Synonym:  Synonym not specified
Accession:  P02965
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p34</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r54"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="r5" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s3</celldesigner:baseReactants>
<celldesigner:baseProducts>s4</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a3" reactant="s3" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:editPoints>0.33333333333333337,-4.440892098500626E-16 0.6666666666666669,0.0</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s3">
<annotation>
<celldesigner:alias>a3</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s3">
<annotation>
<celldesigner:alias>a3</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s4">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="r6" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s4</celldesigner:baseReactants>
<celldesigner:baseProducts>s6</celldesigner:baseProducts>
<celldesigner:offset x="1.0" y="0.0"/>
<celldesigner:editPoints>0.3333333333333335,-4.440892098500626E-16 0.6666666666666672,-8.881784197001252E-16</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s4">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s6">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="r38" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s6</celldesigner:baseReactants>
<celldesigner:baseProducts>s71</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333335,8.881784197001252E-16 0.6666666666666679,0.0</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s6">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s71">
<annotation>
<celldesigner:alias>a79</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="r39" reversible="false">
<annotation>
<celldesigner:reactionType>TRUNCATION</celldesigner:reactionType>
<celldesigner:baseReactants>s71</celldesigner:baseReactants>
<celldesigner:baseProducts>s90,s74</celldesigner:baseProducts>
<celldesigner:offset x="3.0" y="0.0"/>
<celldesigner:editPoints>0.3333333333333339,0.0 0.666666666666667,1.7763568394002505E-15 0.3333333333333339,-8.881784197001252E-16 0.6666666666666679,0.0 0.3333333333333339,-4.440892098500626E-16 0.6666666666666661,4.440892098500626E-16 0.30190189197491457,0.3296855800034484</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s71">
<annotation>
<celldesigner:alias>a79</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s90">
<annotation>
<celldesigner:alias>a80</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s74">
<annotation>
<celldesigner:alias>a81</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="r40" reversible="false">
<annotation>
<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
<celldesigner:baseReactants>s74</celldesigner:baseReactants>
<celldesigner:baseProducts>s75</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333339,-8.881784197001252E-16 0.6666666666666679,-8.881784197001252E-16</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s74">
<annotation>
<celldesigner:alias>a81</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s75">
<annotation>
<celldesigner:alias>a82</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="r41" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s77</celldesigner:baseReactants>
<celldesigner:baseProducts>s78</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333326,0.0 0.6666666666666667,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a88" editPoints="0.33333333333333326,0.0 0.6666666666666665,1.3322676295501878E-15" modifiers="s83" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s77">
<annotation>
<celldesigner:alias>a83</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s78">
<annotation>
<celldesigner:alias>a84</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s83">
<annotation>
<celldesigner:alias>a88</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r44" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s78</celldesigner:baseReactants>
<celldesigner:baseProducts>s79</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a78" reactant="s8" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a96" product="s96" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333335,0.0 0.666666666666667,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a89" editPoints="0.33333333333333337,0.0 0.6666666666666669,0.0" modifiers="s85" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s78">
<annotation>
<celldesigner:alias>a84</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s8">
<annotation>
<celldesigner:alias>a78</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s79">
<annotation>
<celldesigner:alias>a85</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s96">
<annotation>
<celldesigner:alias>a96</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s85">
<annotation>
<celldesigner:alias>a89</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r46" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s81</celldesigner:baseReactants>
<celldesigner:baseProducts>s82</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a42" reactant="s42" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a92" product="s92" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333335,-4.440892098500626E-16 0.666666666666667,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a91" editPoints="0.33333333333333337,-8.881784197001252E-16 0.6666666666666666,-8.881784197001252E-16" modifiers="s89" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s81">
<annotation>
<celldesigner:alias>a87</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s42">
<annotation>
<celldesigner:alias>a42</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s82">
<annotation>
<celldesigner:alias>a86</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s92">
<annotation>
<celldesigner:alias>a92</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s89">
<annotation>
<celldesigner:alias>a91</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r48" reversible="false">
<annotation>
<celldesigner:reactionType>TRUNCATION</celldesigner:reactionType>
<celldesigner:baseReactants>s79</celldesigner:baseReactants>
<celldesigner:baseProducts>s81,s90</celldesigner:baseProducts>
<celldesigner:offset x="11.0" y="25.0"/>
<celldesigner:editPoints>0.33333333333333304,-4.440892098500626E-16 0.6666666666666665,4.440892098500626E-16 0.3333333333333332,0.0 0.6666666666666669,-4.440892098500626E-16 0.33666805781465936,-0.007014930331675329 1.006667054133346,-0.02413601997755266 0.31997967223239376,0.18646999567742784</celldesigner:editPoints>
<celldesigner:listOfModification>
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</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s79">
<annotation>
<celldesigner:alias>a85</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s81">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s90">
<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s87">
<annotation>
<celldesigner:alias>a90</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r49" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s81</celldesigner:baseReactants>
<celldesigner:baseProducts>s74</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a94" reactant="s8" targetLineIndex="-1,0"/>
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</sbml>


