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<![CDATA[
GABA (gamma-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system.  It mediates its action through the ionotropic GABA-A and GABA-B receptors.  GABA-A receptors form ion channels, while GABA-B receptors are G-protein coupled receptors.  This pathway focuses on signaling pathway mediated by GABA-B receptor.

GABA-B receptor are located on both presynaptic and postsynaptic membrane.  Presynaptic GABA-B receptors are subdivided into autoreceptors that control GABA release, and heteroreceptors that inhibits all other neurotransmitter release.  Upon binding to GABA, the presynaptic GABA-B receptor decreases Ca ion influx by inhibiting voltage-dependent Ca channels, particularly N-type and P/Q type, via beta and gamma subunit of G protein, thus lowering the presynaptic Ca concentration and decreasing neurotransmitter release.  Postsynaptic GABA-B receptors induce a slow inhibitory postsynaptic current through the activation of an inward rectifying K channel (GIRK).  In addition, recent studies found that synaptic plasticity can be controlled by the cAMP pathway.

GABA-B receptors have been found to play a role in the field of substance abuse or addition.  It has been reported that administration of GABA-B agonist, such as baclofen, can reduce patients' craving for cocaine or alcohol.  Recently, an association study showed close linkage between several SNPs of GABA B2 receptor and nicotine dependency.
Medline=11311380
Medline=16539894
OMIM=607340
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<celldesigner:bounds h="28.0" w="30.0" x="569.75" y="817.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
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<celldesigner:boxSize height="28.0" width="30.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="sa61" species="s83">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="29.0" w="49.0" x="436.0" y="815.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
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<celldesigner:boxSize height="29.0" width="49.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="sa62" species="s84">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="40.0" w="80.0" x="807.0" y="751.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-44.0" y="78.0"/>
<celldesigner:boxSize height="40.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="sa63" species="s84">
<celldesigner:activity>active</celldesigner:activity>
<celldesigner:bounds h="40.0" w="80.0" x="807.5" y="871.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-43.5" y="198.5"/>
<celldesigner:boxSize height="40.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca2" id="sa64" species="s86">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="25.0" x="735.5" y="875.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-115.5" y="202.5"/>
<celldesigner:boxSize height="25.0" width="25.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ff9999ff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa65" species="s87">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="25.0" w="25.0" x="930.0" y="876.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="25.0" width="25.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ff9999ff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
</celldesigner:listOfSpeciesAliases>
<celldesigner:listOfGroups/>
<celldesigner:listOfProteins>
<celldesigner:protein id="pr2" name="G_sub_i_slash_o_endsub__alpha_" type="GENERIC"/>
<celldesigner:protein id="pr1" name="GABA_minus_B_br_receptor" type="RECEPTOR"/>
<celldesigner:protein id="pr3" name="G_beta_" type="GENERIC"/>
<celldesigner:protein id="pr4" name="G_gamma_" type="GENERIC"/>
<celldesigner:protein id="pr5" name="Ca channel" type="ION_CHANNEL"/>
<celldesigner:protein id="pr6" name="AC" type="GENERIC"/>
<celldesigner:protein id="pr7" name="PKA" type="GENERIC"/>
<celldesigner:protein id="p10" name="SNARE Complex" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="5.84" id="rs1"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="pr8" name="K channel" type="ION_CHANNEL"/>
</celldesigner:listOfProteins>
<celldesigner:listOfGenes/>
<celldesigner:listOfRNAs/>
<celldesigner:listOfAntisenseRNAs/>
<celldesigner:listOfBlockDiagrams/>
</annotation>
<listOfCompartments>
<compartment id="default"/>
<compartment id="c1" name="Presynaptic" outside="default">
<annotation>
<celldesigner:name >Presynaptic</celldesigner:name>
</annotation>
</compartment>
<compartment id="c2" name="Postsynaptic" outside="default">
<annotation>
<celldesigner:name >Postsynaptic</celldesigner:name>
</annotation>
</compartment>
<compartment id="c3" name="Synaptic vesicle" outside="c1">
<annotation>
<celldesigner:name >Synaptic vesicle</celldesigner:name>
</annotation>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species compartment="default" id="s4" initialAmount="0.0" name="GABA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GABA
Synonym:  Synonym not specified
Accession:  S05809
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GABA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s18" initialAmount="0.0" name="GABA_minus_B receptor_slash__br_G protein_br_complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GABA-B receptor/ G protein complex
Synonym:  Synonym not specified
Accession:  U05887
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>GABA_minus_B receptor_slash__br_G protein_br_complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s24" initialAmount="0.0" name="G_sub_i_slash_o_endsub__alpha_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gi/oalpha
Synonym:  Synonym not specified
Accession:  P05757
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions >
<celldesigner:catalyzed reaction="re7"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s27" initialAmount="0.0" name="G_beta__gamma_ complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gbetagamma complex
Synonym:  Synonym not specified
Accession:  U05888
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>G_beta__gamma_ complex</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions >
<celldesigner:catalyzed reaction="re5"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s28" initialAmount="0.0" name="GABA_minus_B_br_receptor_slash__br_GABA complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GABA-B receptor/ GABA complex
Synonym:  Synonym not specified
Accession:  U05889
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>GABA_minus_B_br_receptor_slash__br_GABA complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s33" initialAmount="0.0" name="GABA_minus_B_br_receptor_slash__br_GABA_slash__br_G protein complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GABA-B receptor/ GABA/ G protein complex
Synonym:  Synonym not specified
Accession:  U05890
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>GABA_minus_B_br_receptor_slash__br_GABA_slash__br_G protein complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s39" initialAmount="0.0" name="Ca channel">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Voltage-dependent Ca channel
Synonym:  Synonym not specified
Accession:  P05753
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions >
<celldesigner:catalyzed reaction="re6"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s40" initialAmount="0.0" name="Ca_super_2_plus_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ca2+
Synonym:  Synonym not specified
Accession:  U05899
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Ca_super_2_plus_</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s41" initialAmount="0.0" name="Ca_super_2_plus_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ca2+
Synonym:  Synonym not specified
Accession:  U05899
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Ca_super_2_plus_</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s42" initialAmount="0.0" name="AC">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Adenylate cyclase
Synonym:  adenylyl cyclase,adenyl cyclase
Accession:  P05760
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions >
<celldesigner:catalyzed reaction="re8"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s43" initialAmount="0.0" name="PKA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  cAMP-dependent protein kinase
Synonym:  Synonym not specified
Accession:  P05752
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s45" initialAmount="0.0" name="Modulate neuronal function">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Modulate neuronal function
Synonym:  Synonym not specified
Accession:  U05896
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Modulate neuronal function</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s44" initialAmount="0.0" name="Target ion channel modulation">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Target ion channel modulation
Synonym:  Synonym not specified
Accession:  U05900
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Target ion channel modulation</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s53" initialAmount="0.0" name="Complex_br_(SNARE Complex/Ca_super_2+)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05891
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(SNARE Complex/Ca_super_2+)</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions >
<celldesigner:catalyzed reaction="re18"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" id="s56" initialAmount="0.0" name="SNARE Complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  N-ethylmaleimide-sensitive factor attachment protein receptor
Synonym:  SNARE
Accession:  P05759
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s62" initialAmount="0.0" name="Neurotransmitter">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Glutamate
Synonym:  Synonym not specified
Accession:  S05810
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Neurotransmitter</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s64" initialAmount="0.0" name="Neurotransmitter">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Glutamate
Synonym:  Synonym not specified
Accession:  S05810
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Neurotransmitter</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s65" initialAmount="0.0" name="GABA_minus_B receptor_slash__br_G protein_br_complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GABA-B receptor/ G protein complex
Synonym:  Synonym not specified
Accession:  U05892
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>GABA_minus_B receptor_slash__br_G protein_br_complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s70" initialAmount="0.0" name="GABA_minus_B_br_receptor_slash__br_GABA_slash__br_G protein complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GABA-B receptor/ GABA/ G protein complex
Synonym:  Synonym not specified
Accession:  U05893
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>GABA_minus_B_br_receptor_slash__br_GABA_slash__br_G protein complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s77" initialAmount="0.0" name="GABA_minus_B_br_receptor_slash__br_GABA complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GABA-B receptor/ GABA complex
Synonym:  Synonym not specified
Accession:  U05894
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>GABA_minus_B_br_receptor_slash__br_GABA complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s80" initialAmount="0.0" name="G_beta__gamma_ complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gbetagamma complex
Synonym:  Synonym not specified
Accession:  U05895
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>G_beta__gamma_ complex</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions >
<celldesigner:catalyzed reaction="re21"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c2" id="s83" initialAmount="0.0" name="G_sub_i_slash_o_endsub__alpha_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Gi/oalpha
Synonym:  Synonym not specified
Accession:  P05757
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s84" initialAmount="0.0" name="K channel">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Inwardly rectifying potassium channel Kir3.1
Synonym:  GIRK1,KCNJ3
Accession:  P05758
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions >
<celldesigner:catalyzed reaction="re22"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c2" id="s86" initialAmount="0.0" name="K_super__plus_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+
Synonym:  Synonym not specified
Accession:  U05898
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>K_super__plus_</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s87" initialAmount="0.0" name="K_super__plus_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+
Synonym:  Synonym not specified
Accession:  U05898
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>K_super__plus_</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="re3" reversible="false">
<annotation>
<celldesigner:reactionType >HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="csa2" species="s18">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant alias="sa3" species="s4">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="csa1" species="s33">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" >0.6989097972055713,0.5229214093272895</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0" />
</annotation>
<listOfReactants>
<speciesReference species="s18">
<annotation>
<celldesigner:alias >csa2</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s4">
<annotation>
<celldesigner:alias >sa3</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s33">
<annotation>
<celldesigner:alias >csa1</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re4" reversible="false">
<annotation>
<celldesigner:reactionType >DISSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="csa1" species="s33">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="csa4" species="s28">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
<celldesigner:baseProduct alias="sa12" species="s24">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfProductLinks >
<celldesigner:productLink alias="csa3" product="s27" targetLineIndex="2,0">
<celldesigner:linkAnchor position="N"/>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:productLink>
</celldesigner:listOfProductLinks>
<celldesigner:connectScheme connectPolicy="direct" >
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<celldesigner:lineDirection arm="2" index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
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<celldesigner:editPoints num0="0" num1="0" num2="1" >0.3039641672759732,-0.006320376350731127 0.4225794475794471,0.5324547074547081</celldesigner:editPoints>
<celldesigner:line color="ff000000" width="1.0" />
</annotation>
<listOfReactants>
<speciesReference species="s33">
<annotation>
<celldesigner:alias >csa1</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s28">
<annotation>
<celldesigner:alias >csa4</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s24">
<annotation>
<celldesigner:alias >sa12</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s27">
<annotation>
<celldesigner:alias >csa3</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re5" reversible="false">
<annotation>
<celldesigner:reactionType >STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa20" species="s39">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa21" species="s39">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0" />
<celldesigner:listOfModification >
<celldesigner:modification aliases="csa3" modifiers="s27" targetLineIndex="-1,0" type="INHIBITION">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget alias="csa3" species="s27">
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</celldesigner:linkTarget>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s39">
<annotation>
<celldesigner:alias >sa20</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s39">
<annotation>
<celldesigner:alias >sa21</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s27">
<annotation>
<celldesigner:alias >csa3</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re6" reversible="false">
<annotation>
<celldesigner:reactionType >TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa22" species="s40">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa23" species="s41">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0" />
<celldesigner:listOfModification >
<celldesigner:modification aliases="sa21" modifiers="s39" targetLineIndex="-1,0" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget alias="sa21" species="s39">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s40">
<annotation>
<celldesigner:alias >sa22</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s41">
<annotation>
<celldesigner:alias >sa23</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s39">
<annotation>
<celldesigner:alias >sa21</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re7" reversible="false">
<annotation>
<celldesigner:reactionType >STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa24" species="s42">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa25" species="s42">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0" />
<celldesigner:listOfModification >
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</celldesigner:connectScheme>
<celldesigner:linkTarget alias="sa12" species="s24">
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</celldesigner:linkTarget>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s42">
<annotation>
<celldesigner:alias >sa24</celldesigner:alias>
</annotation>
</speciesReference>
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<listOfProducts>
<speciesReference species="s42">
<annotation>
<celldesigner:alias >sa25</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s24">
<annotation>
<celldesigner:alias >sa12</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re8" reversible="false">
<annotation>
<celldesigner:reactionType >STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa26" species="s43">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa27" species="s43">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
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</celldesigner:listOfLineDirection>
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<celldesigner:linkTarget alias="sa25" species="s42">
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</celldesigner:listOfModification>
</annotation>
<listOfReactants>
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<annotation>
<celldesigner:alias >sa26</celldesigner:alias>
</annotation>
</speciesReference>
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<annotation>
<celldesigner:alias >sa27</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s42">
<annotation>
<celldesigner:alias >sa25</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re9" reversible="false">
<annotation>
<celldesigner:reactionType >KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
<celldesigner:baseReactants >
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</celldesigner:baseReactants>
<celldesigner:baseProducts >
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<celldesigner:line color="ff000000" width="1.0" />
</annotation>
<listOfReactants>
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<annotation>
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<annotation>
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</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re10" reversible="false">
<annotation>
<celldesigner:reactionType >KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
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<celldesigner:baseProducts >
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</annotation>
<listOfReactants>
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<annotation>
<celldesigner:alias >sa27</celldesigner:alias>
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</speciesReference>
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<annotation>
<celldesigner:alias >sa29</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re17" reversible="false">
<annotation>
<celldesigner:reactionType >HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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<annotation>
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<annotation>
<celldesigner:alias >csa6</celldesigner:alias>
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</speciesReference>
</listOfProducts>
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<reaction id="re18" reversible="false">
<annotation>
<celldesigner:reactionType >TRANSPORT</celldesigner:reactionType>
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<celldesigner:baseProducts >
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</annotation>
<listOfReactants>
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<annotation>
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</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s53">
<annotation>
<celldesigner:alias >csa6</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re19" reversible="false">
<annotation>
<celldesigner:reactionType >HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants >
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</celldesigner:baseReactants>
<celldesigner:baseProducts >
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
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<celldesigner:alias >csa8</celldesigner:alias>
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<annotation>
<celldesigner:alias >csa9</celldesigner:alias>
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<reaction id="re20" reversible="false">
<annotation>
<celldesigner:reactionType >DISSOCIATION</celldesigner:reactionType>
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<annotation>
<celldesigner:alias >csa9</celldesigner:alias>
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<celldesigner:alias >csa10</celldesigner:alias>
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<annotation>
<celldesigner:alias >csa11</celldesigner:alias>
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<celldesigner:alias >sa61</celldesigner:alias>
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</reaction>
<reaction id="re21" reversible="false">
<annotation>
<celldesigner:reactionType >STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa62" species="s84">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa63" species="s84">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0" />
<celldesigner:listOfModification >
<celldesigner:modification aliases="csa11" modifiers="s80" targetLineIndex="-1,0" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget alias="csa11" species="s80">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s84">
<annotation>
<celldesigner:alias >sa62</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s84">
<annotation>
<celldesigner:alias >sa63</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s80">
<annotation>
<celldesigner:alias >csa11</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re22" reversible="false">
<annotation>
<celldesigner:reactionType >TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants >
<celldesigner:baseReactant alias="sa64" species="s86">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts >
<celldesigner:baseProduct alias="sa65" species="s87">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" >
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line color="ff000000" width="1.0" />
<celldesigner:listOfModification >
<celldesigner:modification aliases="sa63" modifiers="s84" targetLineIndex="-1,0" type="CATALYSIS">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget alias="sa63" species="s84">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line color="ff000000" width="1.0"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s86">
<annotation>
<celldesigner:alias >sa64</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s87">
<annotation>
<celldesigner:alias >sa65</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s84">
<annotation>
<celldesigner:alias >sa63</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
</listOfReactions>
</model>
</sbml>


