2.3 SQUARE_CLOSEUP_NORTH OVAL inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive active inactive inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive Cytosol Nucleus Long Name: ATP Synonym: Synonym not specified Accession: S01736 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01739 inside SIMPLE_MOLECULE ADP Long Name: Insulin/Insulin like growth factor Synonym: IGF,IGF1,IGF2,Insulin like growth factor 1,Insulin like growth factor 2 Accession: P00896 inside PROTEIN p2 Long Name: Insulin receptor substrate family Synonym: IRS Accession: P00899 inside PROTEIN p4 Long Name: Insulin receptor substrate family Synonym: IRS Accession: P00899 inside PROTEIN p4 Long Name: Insulin receptor/Insulin like growth factor receptor/insulin related receptor Synonym: IGF-R,IGF-R1,IGF-R2,INSR,IRR,Insulin R,Insulin like growth factor receptor 1,Insulin like growth factor receptor 2 Accession: P00895 transmembrane PROTEIN p1 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05321 Heterodimer Member Info: INSR IGF-R IRR#PROTEIN#Insulin receptor/Insulin like growth factor receptor/insulin related receptor#P00895#IGF-R|IGF-R1|IGF-R2|INSR|IRR|Insulin R|Insulin like growth factor receptor 1|Insulin like growth factor receptor 2#;Insulin IGF#PROTEIN#Insulin/Insulin like growth factor#P00896#IGF|IGF1|IGF2|Insulin like growth factor 1|Insulin like growth factor 2# transmembrane PROTEIN p2 PROTEIN p1 Long Name: Phosphatidylinositol 3-kinase Synonym: PI3-K,PI3K,Phosphoinositide 3-OH-kinase,Phosphoinositide 3-kinase Accession: P00900 inside PROTEIN p14 Long Name: PiP2 Synonym: Synonym not specified Accession: S01738 inside SIMPLE_MOLECULE PiP2 Long Name: PiP3 Synonym: Synonym not specified Accession: S01737 inside SIMPLE_MOLECULE PiP3 Long Name: Phosphatase and tensin homolog Synonym: PTEN,Phosphatidylinositol phosphate phosphatase,PtdIns phosphate phosphatase Accession: P00905 inside PROTEIN p15 Long Name: SH2 domain-containing inositol 5-phosphatase 2 Synonym: INPP5D,Inositol polyphosphate-5-phosphatase,SHIP2 Accession: P00897 inside PROTEIN p16 Long Name: 3-phosphoinositide-dependent protein kinase Synonym: Synonym not specified Accession: P00903 inside PROTEIN p17 Long Name: Glycogen synthase kinase 3 Synonym: Synonym not specified Accession: P00902 inside PROTEIN p21 Long Name: Glycogen synthase kinase 3 Synonym: Synonym not specified Accession: P00902 inside PROTEIN p21 Long Name: Glycogen synthesis Synonym: Synonym not specified Accession: U02393 inside PHENOTYPE Glycogen synthesis Long Name: ATP Synonym: Synonym not specified Accession: S01736 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01739 inside SIMPLE_MOLECULE ADP Long Name: p53 Synonym: Synonym not specified Accession: P04497 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1*P00059|P01485|p53 pathway inside PROTEIN p23 Long Name: PTEN Synonym: Synonym not specified Accession: G04675 inside GENE PTEN Long Name: Mdm2 Synonym: Synonym not specified Accession: P04496 Pathway Link: P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1*P00059|P01483|p53 pathway inside PROTEIN p24 Long Name: Mdm2 Synonym: Synonym not specified Accession: P04496 Pathway Link: P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1*P00059|P01483|p53 pathway inside PROTEIN p24 Long Name: Mdm2 Synonym: Synonym not specified Accession: G04674 inside GENE Mdm2 Long Name: p53 Synonym: Synonym not specified Accession: P04497 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1*P00059|P01485|p53 pathway inside PROTEIN p23 Long Name: P110alpha Synonym: P110-alpha,PIK3CA Accession: P04498 inside PROTEIN p33 Long Name: p110alpha Synonym: P110-alpha,PIK3CA Accession: G04676 inside GENE p110_alpha_ Long Name: Long name not specified Synonym: Synonym not specified Accession: U05320 Heterodimer Member Info: PI3-K#PROTEIN#Phosphatidylinositol 3-kinase#P00900#PI3-K|PI3K|Phosphoinositide 3-OH-kinase|Phosphoinositide 3-kinase#;P110alpha#PROTEIN#P110alpha#P04498#P110-alpha|PIK3CA# inside PROTEIN p14 PROTEIN p33 Long Name: P53 pathway Synonym: Synonym not specified Accession: U05325 inside PHENOTYPE P53_space_pathway Long Name: Cell growth low ROS high HSP Synonym: Synonym not specified Accession: U05326 inside PHENOTYPE Cell growth_br_low_space_ROS_br_high HSP Long Name: Forkhead transcription factor Synonym: FOXO1A,Forkhead box O1A,Forkhead in rhabdomyosarcoma Accession: P00898 inside PROTEIN p20 Long Name: Forkhead transcription factor Synonym: FOXO1A,Forkhead box O1A,Forkhead in rhabdomyosarcoma Accession: P00898 inside PROTEIN p20 Long Name: Forkhead transcription factor Synonym: FOXO1A,Forkhead box O1A,Forkhead in rhabdomyosarcoma Accession: P00898 inside PROTEIN p20 Long Name: p27 Apoptosis Synonym: Synonym not specified Accession: U05327 inside PHENOTYPE p27_br_Apoptosis Long Name: Cell survival Synonym: Synonym not specified Accession: U02392 inside PHENOTYPE Cell survival_br_maintenance Long Name: Hamartin Synonym: Tuberous sclerosis-1 Accession: P04495 inside PROTEIN p26 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05323 Heterodimer Member Info: Tsc2#PROTEIN#Tuberin#P04494##;Tsc1#PROTEIN#Hamartin#P04495#Tuberous sclerosis-1# inside PROTEIN p26 PROTEIN p25 Long Name: Tuberin Synonym: Synonym not specified Accession: P04494 innerSurface PROTEIN p25 Long Name: Glucose depreivation response Synonym: Synonym not specified Accession: U05324 inside PHENOTYPE Glucose depreivation_br_response Long Name: Long name not specified Synonym: Synonym not specified Accession: U05322 Heterodimer Member Info: Tsc2#PROTEIN#Tuberin#P04494##;Tsc1#PROTEIN#Hamartin#P04495#Tuberous sclerosis-1# inside PROTEIN p25 PROTEIN p26 Long Name: Protein kinase B Synonym: AKT,PKB Accession: P00894 Pathway Link: P04397|P04641|p53 pathway by glucose deprivation*P04398|P04665|p53 pathway feedback loops 2*P00059|P01486|p53 pathway inside PROTEIN p18 Long Name: Protein kinase B Synonym: AKT,PKB Accession: P00894 Pathway Link: P04397|P04641|p53 pathway by glucose deprivation*P04398|P04665|p53 pathway feedback loops 2*P00059|P01486|p53 pathway inside PROTEIN p18 HETERODIMER_ASSOCIATION s2,s1 s5 0.33333333333333304,-1.1102230246251565E-16 0.6666666666666665,-1.1102230246251565E-16 0.3333333333333335,0.0 0.666666666666667,-4.440892098500626E-16 0.3333333333333335,0.0 0.6666666666666665,-2.220446049250313E-16 0.3333333333333336,0.3333333333333335 a2 a1 a5 STATE_TRANSITION s7 s22 0.3333333333333326,4.884981308350689E-15 0.6666666666666665,9.547918011776346E-15 a7 a9 a8 a10 a5 STATE_TRANSITION s30 s31 0.3333333333333335,-2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 a48 a49 a88 STATE_TRANSITION s31 s30 0.33333333333333304,2.220446049250313E-16 0.6666666666666665,2.220446049250313E-16 a49 a48 a51 a50 STATE_TRANSITION s34 s34 0.3333333333333335,8.881784197001252E-16 0.6666666666666669,1.3322676295501878E-15 a52 a56 a49 STATE_TRANSITION s35 s37 0.3333333333333335,4.440892098500626E-16 0.6666666666666666,4.440892098500626E-16 a53 a59 a57 a60 a56 STATE_TRANSITION s39 s43 0.33333333333333215,0.0 0.666666666666667,0.0 a65 a68 a62 a70 a57 KNOWN_TRANSITION_OMITTED s39 s44 0.3333333333333335,-8.881784197001252E-16 0.6666666666666665,-8.881784197001252E-16 a65 a72 STATE_TRANSITION s38 s41 0.33333333333333215,0.0 0.6666666666666661,0.0 a66 a69 a61 a71 a57 TRANSPORT s41 s49 0.3333333333333335,0.0 0.6666666666666665,0.0 a61 a76 TRANSCRIPTIONAL_ACTIVATION s50 s51 0.33333333333333304,0.0 0.666666666666667,0.0 a77 a78 STATE_TRANSITION s53 s54 0.3333333333333339,-2.220446049250313E-16 0.6666666666666661,-5.551115123125783E-16 a80 a81 a57 TRANSCRIPTIONAL_ACTIVATION s50 s55 0.3333333333333329,-4.440892098500626E-16 0.6666666666666664,-4.440892098500626E-16 a77 a82 STATE_TRANSITION s56 s50 0.33333333333333326,0.0 0.6666666666666663,0.0 a84 a77 TRANSCRIPTIONAL_INHIBITION s50 s58 0.3333333333333335,-4.440892098500626E-16 0.6666666666666665,-4.440892098500626E-16 a77 a86 HETERODIMER_ASSOCIATION s29,s57 s59 0.3333333333333339,-4.440892098500626E-16 0.6666666666666679,4.440892098500626E-16 0.33333333333333415,8.881784197001252E-16 0.6666666666666663,8.881784197001252E-16 0.3333333333333339,0.0 0.666666666666667,1.3322676295501878E-15 0.3333333333333339,0.33333333333333304 a46 a85 a88 a8 KNOWN_TRANSITION_OMITTED s50 s60 0.3333333333333334,-2.220446049250313E-16 0.6064246897923179,0.05744526421471896 a77 a89 KNOWN_TRANSITION_OMITTED s49 s63 0.3333333333333335,0.0 0.666666666666667,0.0 a76 a92 KNOWN_TRANSITION_OMITTED s41 s45 0.3333333333333326,0.0 0.6666666666666656,0.0 a61 a73 KNOWN_TRANSITION_OMITTED s38 s64 0.3333333333333335,0.0 0.666666666666667,-8.881784197001252E-16 a66 a93 KNOWN_TRANSITION_OMITTED s68 s70 0.28522737810000276,0.022779353183355333 0.4398693064668904,-0.08299714611106612 a104 a108 INHIBITION s54 s50 0.27253085672081134,-0.33619631386908055 0.6148938236526931,-0.26126561960664507 a81 a77 KNOWN_TRANSITION_OMITTED s54 s60 0.33333333333333326,-4.440892098500626E-16 0.5224056722440098,0.11708699915561949 a81 a89 STATE_TRANSITION s68 s71 0.3333333333333339,1.7763568394002505E-15 0.6666666666666679,-1.7763568394002505E-15 a104 a110 a57 DISSOCIATION s71 s62,s65 0.3333333333333339,1.3322676295501878E-15 0.6666666666666661,4.440892098500626E-16 0.33333333333333215,0.0 0.6666666666666643,-3.552713678800501E-15 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666679,-8.881784197001252E-16 0.33333333333333215,0.3333333333333357 a110 a106 a107 KNOWN_TRANSITION_OMITTED s55 s53 0.3333333333333327,8.881784197001252E-16 0.6666666666666666,8.881784197001252E-16 a82 a80 KNOWN_TRANSITION_OMITTED s58 s57 0.33333333333333304,8.881784197001252E-16 0.6666666666666652,4.440892098500626E-16 a86 a85 KNOWN_TRANSITION_OMITTED s51 s32 0.3333333333333335,4.440892098500626E-16 0.6666666666666665,0.0 a78 a50