2.2 SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive active inactive active inactive active inactive inactive inactive active inactive inactive inactive active inactive inactive inactive active inactive active inactive active inactive Cytosol Long Name: ATP Synonym: Synonym not specified Accession: S01734 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01735 inside SIMPLE_MOLECULE ADP Long Name: Ras Synonym: Synonym not specified Accession: P00886 inside PROTEIN p7 Long Name: Raf Synonym: Raf oncogene Accession: P00893 inside PROTEIN p8 Long Name: Raf Synonym: Raf oncogene Accession: P00893 inside PROTEIN p8 Long Name: Mitogen-activated protein kinase kinase Synonym: MAP kinase kinase,MAP/ERK kinase,MAPKK,Mitogen-activated ERK activating kinase Accession: P00891 inside PROTEIN p9 Long Name: Mitogen-activated protein kinase kinase Synonym: MAP kinase kinase,MAP/ERK kinase,MAPKK,Mitogen-activated ERK activating kinase Accession: P00891 inside PROTEIN p9 Long Name: ELK1, member of ETS oncogen family Synonym: ELK1,Oncogen ELK1 Accession: P00890 inside PROTEIN p11 Long Name: ELK1, member of ETS oncogen family Synonym: ELK1,Oncogen ELK1 Accession: P00890 inside PROTEIN p11 Long Name: 90 kDa ribosomal protein S6 kinase Synonym: Synonym not specified Accession: P00888 inside PROTEIN p12 Long Name: 90 kDa ribosomal protein S6 kinase Synonym: Synonym not specified Accession: P00888 inside PROTEIN p12 Long Name: c-fos Synonym: Synonym not specified Accession: P00884 inside PROTEIN p13 Long Name: c-fos Synonym: Synonym not specified Accession: P00884 inside PROTEIN p13 Long Name: Gene transcription Synonym: Synonym not specified Accession: U02389 inside PHENOTYPE Gene_space_transcription Long Name: Insulin/Insulin like growth factor Synonym: IGF,IGF1,IGF2,Insulin like growth factor 1,Insulin like growth factor 2 Accession: P00882 inside PROTEIN p2 Long Name: Son of sevenless Synonym: SOS,SOS1 guanine nucleotide exchange factor Accession: P00883 inside PROTEIN p6 Long Name: Growth factor receptor bound protein 2 Synonym: ASH protein,Abundant Src homology,Grb2 Accession: P00892 inside PROTEIN p5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05328 Heterodimer Member Info: SOS#PROTEIN#Son of sevenless#P00883#SOS|SOS1 guanine nucleotide exchange factor#;Grb2#PROTEIN#Growth factor receptor bound protein 2#P00892#ASH protein|Abundant Src homology|Grb2# inside PROTEIN p6 PROTEIN p5 Long Name: Insulin receptor substrate family Synonym: IRS Accession: P00887 inside PROTEIN p4 Long Name: Insulin receptor substrate family Synonym: IRS Accession: P00887 inside PROTEIN p4 Long Name: Insulin receptor/Insulin like growth factor receptor/insulin related receptor Synonym: IGF-R,IGF-R1,IGF-R2,INSR,IRR,Insulin R,Insulin like growth factor receptor 1,Insulin like growth factor receptor 2 Accession: P00885 transmembrane PROTEIN p1 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05329 Heterodimer Member Info: Insulin IGF#PROTEIN#Insulin/Insulin like growth factor#P00882#IGF|IGF1|IGF2|Insulin like growth factor 1|Insulin like growth factor 2#;INSR IGF-R IRR#PROTEIN#Insulin receptor/Insulin like growth factor receptor/insulin related receptor#P00885#IGF-R|IGF-R1|IGF-R2|INSR|IRR|Insulin R|Insulin like growth factor receptor 1|Insulin like growth factor receptor 2# transmembrane PROTEIN p2 PROTEIN p1 Long Name: Mitogen-activated protein kinase Synonym: Extracellular signal-regulated kinase,MAP kinase,MAPK Accession: P00889 inside PROTEIN p10 Long Name: Mitogen-activated protein kinase Synonym: Extracellular signal-regulated kinase,MAP kinase,MAPK Accession: P00889 inside PROTEIN p10 HETERODIMER_ASSOCIATION s2,s1 s5 0.33333333333333304,-1.1102230246251565E-16 0.6666666666666665,-1.1102230246251565E-16 0.3333333333333335,0.0 0.666666666666667,-4.440892098500626E-16 0.3333333333333335,0.0 0.6666666666666665,-2.220446049250313E-16 0.3333333333333336,0.3333333333333335 a2 a1 a5 STATE_TRANSITION s7 s22 0.3333333333333326,4.884981308350689E-15 0.6666666666666665,9.547918011776346E-15 a7 a9 a8 a10 STATE_TRANSITION s11 s11 0.3333333333333335,3.552713678800501E-15 0.6666666666666665,6.217248937900877E-15 a12 a13 HETERODIMER_ASSOCIATION s12,s11 s13 0.3333333333333335,0.0 0.6666666666666665,0.0 0.33333333333333326,0.0 0.6666666666666667,0.0 0.3333333333333339,0.0 0.6666666666666661,4.440892098500626E-16 0.3333333333333335,0.33333333333333304 a14 a13 a17 STATE_TRANSITION s14 s14 0.3333333333333335,-1.3322676295501878E-15 0.6666666666666669,-2.6645352591003757E-15 a18 a19 STATE_TRANSITION s15 s23 0.33333333333333326,1.3322676295501878E-15 0.6666666666666663,4.440892098500626E-15 a20 a25 a21 a24 STATE_TRANSITION s16 s24 0.3333333333333335,-4.440892098500626E-15 0.666666666666667,-8.43769498715119E-15 a26 a29 a27 a30 STATE_TRANSITION s17 s25 0.3333333333333335,-4.440892098500626E-16 0.6666666666666672,-1.3322676295501878E-15 a31 a34 a32 a35 STATE_TRANSITION s18 s26 0.33333333333333215,0.0 0.6666666666666661,0.0 a36 a37 STATE_TRANSITION s19 s27 0.3333333333333339,8.881784197001252E-16 0.6666666666666661,0.0 a39 a40 STATE_TRANSITION s20 s28 0.3333333333333339,8.881784197001252E-16 0.666666666666667,1.7763568394002505E-15 a42 a43 TRANSCRIPTIONAL_ACTIVATION s26 s21 0.3333333333333326,0.0 0.6666666666666665,-4.440892098500626E-16 a37 a45 TRANSCRIPTIONAL_ACTIVATION s28 s21 0.33333333333333315,0.0 0.6666666666666664,0.0 a43 a45