2.2 SQUARE_CLOSEUP_NORTHWEST SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive inactive inactive active active inactive inactive inactive inactive active active inactive inactive nucleus Membrane Long Name: Janus kinase 2 Synonym: Jak2 Accession: P00952 inside PROTEIN p3 Long Name: Janus kinase 1 Synonym: Jak1 Accession: P00953 inside PROTEIN p2 Long Name: antiviral genes include dsRNA-dependent protein kinase (PKR), 2-5A synthetase, and Mx protein family Synonym: Synonym not specified Accession: U02420 inside PHENOTYPE Gene transcription Long Name: IFNGR2 Synonym: Synonym not specified Accession: P00957 transmembrane PROTEIN p6 Long Name: IFNGR1 Synonym: Synonym not specified Accession: P00959 transmembrane PROTEIN p5 Long Name: Suppressor of cytokine signaling Synonym: CIS,SOCS Accession: P00956 inside PROTEIN p7 Long Name: protein tyrosine phosphatase Synonym: PTP Accession: P00960 inside PROTEIN p8 Long Name: Serine kinase Synonym: Synonym not specified Accession: P00955 inside PROTEIN p9 Long Name: Protein inhibitors of activated STATs Synonym: PIAS Accession: P00958 inside PROTEIN p10 Long Name: ATP Synonym: Synonym not specified Accession: S01741 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01744 inside SIMPLE_MOLECULE ADP Long Name: Pi Synonym: Synonym not specified Accession: S01743 inside SIMPLE_MOLECULE Pi Long Name: Pi Synonym: Synonym not specified Accession: S01743 inside SIMPLE_MOLECULE Pi Long Name: Signal transducers and activaotrs of transcription 1 Synonym: STAT1 Accession: P00961 inside PROTEIN p4 Long Name: Signal transducers and activaotrs of transcription 1 Synonym: STAT1 Accession: P00961 inside PROTEIN p4 Long Name: Signal transducers and activaotrs of transcription 1 Synonym: STAT1 Accession: P00961 inside PROTEIN p4 2 Long Name: Signal transducers and activaotrs of transcription 1 Synonym: STAT1 Accession: P00961 inside PROTEIN p4 2 Long Name: 2 ATP Synonym: Synonym not specified Accession: S01745 inside SIMPLE_MOLECULE 2 ATP Long Name: 2 ADP Synonym: Synonym not specified Accession: S01742 inside SIMPLE_MOLECULE 2 ADP Long Name: Janus kinase 1 Synonym: Jak1 Accession: P00953 inside PROTEIN p2 Long Name: Janus kinase 2 Synonym: Jak2 Accession: P00952 inside PROTEIN p3 Long Name: protein tyrosine phosphatase Synonym: PTP Accession: P00960 inside PROTEIN p8 Long Name: Interferongamma Synonym: Synonym not specified Accession: P00954 inside PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05351 Heterodimer Member Info: Interferongamma#PROTEIN#Interferongamma#P00954##;IFNGR2#PROTEIN#IFNGR2#P00957##;IFNGR1#PROTEIN#IFNGR1#P00959## transmembrane PROTEIN p5 PROTEIN p6 PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05352 Heterodimer Member Info: Jak2#PROTEIN#Janus kinase 2#P00952#Jak2#;Jak1#PROTEIN#Janus kinase 1#P00953#Jak1#;Interferongamma#PROTEIN#Interferongamma#P00954##;IFNGR2#PROTEIN#IFNGR2#P00957##;IFNGR1#PROTEIN#IFNGR1#P00959##;STAT1#PROTEIN#Signal transducers and activaotrs of transcription 1#P00961#STAT1# transmembrane PROTEIN p5 PROTEIN p6 PROTEIN p11 PROTEIN p4 PROTEIN p2 PROTEIN p3 Long Name: ADP Synonym: Synonym not specified Accession: S01744 inside SIMPLE_MOLECULE ADP Long Name: ATP Synonym: Synonym not specified Accession: S01741 inside SIMPLE_MOLECULE ATP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05350 Heterodimer Member Info: Jak2#PROTEIN#Janus kinase 2#P00952#Jak2#;Jak1#PROTEIN#Janus kinase 1#P00953#Jak1#;Interferongamma#PROTEIN#Interferongamma#P00954##;IFNGR2#PROTEIN#IFNGR2#P00957##;IFNGR1#PROTEIN#IFNGR1#P00959## transmembrane PROTEIN p5 PROTEIN p6 PROTEIN p11 PROTEIN p2 PROTEIN p3 TRANSPORT s58 s59 0.33333333333333326,0.0 0.6666666666666665,0.0 a90 a91 STATE_TRANSITION s4 s64 0.33333333333333304,0.0 0.6666666666666665,0.0 a6 a77 a92 a78 STATE_TRANSITION s6 s65 0.33333333333333304,-2.220446049250313E-16 0.6703658697242689,0.0038395891513598457 a7 a138 a93 a137 STATE_TRANSITION s64 s4 0.33333333333333326,0.0 0.6666666666666665,-2.220446049250313E-16 a92 a6 a80 STATE_TRANSITION s65 s6 0.3333333333333333,0.0 0.6666666666666667,0.0 a93 a7 a80 DISSOCIATION s59 s49,s49 0.3333333333333335,1.3322676295501878E-15 0.6666666666666665,2.220446049250313E-15 0.3333333333333348,8.881784197001252E-16 0.6666666666666679,8.881784197001252E-16 0.3333333333333335,0.0 0.6666666666666665,0.0 0.3333333333333339,0.33333333333333215 a91 a73 a74 a87 TRANSCRIPTIONAL_ACTIVATION s59 s17 0.33333333333333304,0.0 0.6666666666666661,-1.3322676295501878E-15 a91 a35 HETERODIMER_ASSOCIATION s23,s24 s75 0.3051405326530223,-0.00127040147763946 0.6666666666666665,8.881784197001252E-16 0.33333333333333304,0.0 0.6666666666666661,-8.881784197001252E-16 0.33333333333333326,8.881784197001252E-16 0.6666666666666661,1.5543122344752192E-15 -8.991787462296651,3.427202197537305 a43 a44 a105 a112 DISSOCIATION s81 s58,s94 0.33333333333333304,0.0 0.6666666666666652,4.440892098500626E-16 0.3333333333333335,-8.881784197001252E-16 0.6666666666666667,-1.7763568394002505E-15 0.33333333333333215,0.0 0.6666666666666661,-4.440892098500626E-16 0.46967914685140555,-0.0013199752026697986 a119 a90 a135 HETERODIMER_ASSOCIATION s75,s65 s94 0.3333333333333326,1.5959455978986625E-16 0.6666666666666665,4.85722573273506E-17 0.3333333333333335,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 0.3333333333333335,1.1102230246251565E-16 0.666666666666667,1.1102230246251565E-16 0.1655932591408208,0.3219674132715026 a112 a93 a92 a100 a136 a101 HETERODIMER_ASSOCIATION s94,s21 s81 0.3333333333333339,-5.551115123125783E-17 0.666666666666667,-2.7755575615628914E-16 0.3333333333333326,0.0 0.6666666666666665,0.0 0.3333333333333335,2.220446049250313E-16 0.666666666666667,6.661338147750939E-16 0.15483335835751855,0.4842186673758908 a136 a28 a83 a119 a84