2.3 SQUARE_CLOSEUP_NORTHEAST SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive active active inactive inactive active active inactive inactive inactive inactive inactive active inactive inactive inactive active active active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive active active active inactive inactive inactive inactive inactive inactive active inactive inactive active inactive active active active active inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active active inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive active active active inactive active active active inactive active Nucleus Cytoplasm Long Name: Signaling subunit Synonym: Synonym not specified Accession: P00969 transmembrane PROTEIN p2 Long Name: Receptor subunit alpha Synonym: Synonym not specified Accession: P00992 transmembrane PROTEIN p1 Long Name: Receptor subunit beta Synonym: Synonym not specified Accession: P00974 transmembrane PROTEIN p3 Long Name: Son of Sevenless Synonym: SOS Accession: P00981 inside PROTEIN p9 Long Name: Phosphatidylinositol 4, 5-bisphosphate Synonym: Synonym not specified Accession: S01746 inside SIMPLE_MOLECULE PIP_sub_2_endsub_ Long Name: Phosphatidylinositol 3, 4, 5- triphosphate Synonym: Synonym not specified Accession: S01750 inside SIMPLE_MOLECULE PIP_sub_3_endsub_ Long Name: Raf Synonym: Synonym not specified Accession: P00983 inside PROTEIN p12 Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P00965 inside PROTEIN p14 Long Name: Mitogen activated protein kinase kinase kinase Synonym: MAP kinase kinase kinase,MAPKKK,MEK kinase,MEKK Accession: P00984 inside PROTEIN p13 Long Name: Mitogen activated protein kinase kinase kinase Synonym: MAP kinase kinase kinase,MAPKKK,MEK kinase,MEKK Accession: P00984 inside PROTEIN p13 Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P00965 inside PROTEIN p14 Long Name: ELK Synonym: Synonym not specified Accession: P00962 inside PROTEIN p15 Long Name: ELK Synonym: Synonym not specified Accession: P00962 inside PROTEIN p15 Long Name: Glycogen synthase kinase 3 Synonym: GSK3 Accession: P00976 inside PROTEIN p17 Long Name: Glycogen synthase kinase 3 Synonym: GSK3 Accession: P00976 inside PROTEIN p17 Long Name: Shc Synonym: Synonym not specified Accession: P00997 inside PROTEIN p18 Long Name: Insulin receptor substrate family Synonym: IRS2,IRS3,IRS4,family includes IRS1 Accession: P00980 inside PROTEIN p5 Long Name: GTP Synonym: Synonym not specified Accession: S01749 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01751 inside SIMPLE_MOLECULE GDP Long Name: Ras GTPase Activity Protein Synonym: RasGAP Accession: P00975 inside PROTEIN p19 Long Name: Growth Factor Receptor Binding Protein 2 Synonym: Abundant SRC homology (ASH),Grb2 Accession: P00971 inside PROTEIN p8 Long Name: Src-like protein tyrosine kinase (PTK) family Synonym: Blk,Bsk),Fgr,Fyn,Gtk,Hck,Lck,Lyn,Rak (Frk,Yes,family includes Src Accession: P00991 inside PROTEIN p20 Long Name: Protein kinase B Synonym: Akt,PKB Accession: P00973 inside PROTEIN p10 Long Name: Protein kinase B Synonym: Akt,PKB Accession: P00973 inside PROTEIN p10 Long Name: Bcl-2 antagonist of cell death Synonym: BAD Accession: P00963 inside PROTEIN p22 Long Name: Bcl-2 antagonist of cell death Synonym: BAD Accession: P00963 inside PROTEIN p22 Long Name: endothelial nitric oxide synthase Synonym: eNOS Accession: P00986 inside PROTEIN p23 Long Name: endothelial nitric oxide synthase Synonym: eNOS Accession: P00986 inside PROTEIN p23 Long Name: Forkhead in Rhabdomyosarcoma-like 1 Synonym: FKHRL1,FOXO3A Accession: P00994 inside PROTEIN p24 Long Name: Forkhead in Rhabdomyosarcoma-like 1 Synonym: FKHRL1,FOXO3A Accession: P00994 inside PROTEIN p24 Long Name: Inhibitor of kappa-B kinase Synonym: IKK Accession: P00968 inside PROTEIN p25 Long Name: mammalian target of rapamycin Synonym: mTOR Accession: P00966 inside PROTEIN p26 Long Name: Cyclin-dependent kinase inhibitor 1A Synonym: CDKN1A,p21,p21CIP1,p21WAF1 Accession: P00993 inside PROTEIN p27 Long Name: Cyclin-dependent kinase inhibitor 1B Synonym: CDKN1B,p27,p27KIP1 Accession: P00982 inside PROTEIN p28 Long Name: Inhibitor of kappa-B kinase Synonym: IKK Accession: P00968 inside PROTEIN p25 Long Name: mammalian target of rapamycin Synonym: mTOR Accession: P00966 inside PROTEIN p26 Long Name: Cyclin-dependent kinase inhibitor 1A Synonym: CDKN1A,p21,p21CIP1,p21WAF1 Accession: P00993 inside PROTEIN p27 Long Name: Cyclin-dependent kinase inhibitor 1B Synonym: CDKN1B,p27,p27KIP1 Accession: P00982 inside PROTEIN p28 Long Name: ATP Synonym: Synonym not specified Accession: S01747 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01748 inside SIMPLE_MOLECULE ADP Long Name: C-terminal modulator protein Synonym: CTMP Accession: P00988 inside PROTEIN p29 Long Name: Signal transducers and activators of transcription Synonym: STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,family members include STAT1 Accession: P00996 inside PROTEIN p6 Long Name: Signal transducers and activators of transcription Synonym: STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,family members include STAT1 Accession: P00996 inside PROTEIN p6 Long Name: Ribosomal protein S6 kinase, 90kD Synonym: RPS6KA1,RSK1,p90RSK Accession: P00964 inside PROTEIN p32 Long Name: Mitogen-activated protein kinase-interacting serine/threonine kinase1/2 Synonym: MAPK-interacting kinase 1/2,MKNK1/2,MNK1/2 Accession: P00972 inside PROTEIN p33 Long Name: Mitogen-activated protein kinase-activated protein kinase 2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P00979 inside PROTEIN p34 Long Name: c-Myc Synonym: Synonym not specified Accession: P00995 inside PROTEIN p30 Long Name: Ets Synonym: Synonym not specified Accession: P00989 inside PROTEIN p31 Long Name: Mitogen-activated protein kinase-interacting serine/threonine kinase1/2 Synonym: MAPK-interacting kinase 1/2,MKNK1/2,MNK1/2 Accession: P00972 inside PROTEIN p33 Long Name: Ribosomal protein S6 kinase, 90kD Synonym: RPS6KA1,RSK1,p90RSK Accession: P00964 inside PROTEIN p32 Long Name: Mitogen-activated protein kinase-activated protein kinase 2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P00979 inside PROTEIN p34 Long Name: c-Myc Synonym: Synonym not specified Accession: P00995 inside PROTEIN p30 Long Name: Ets Synonym: Synonym not specified Accession: P00989 inside PROTEIN p31 Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P00965 inside PROTEIN p14 Long Name: Ribosomal protein S6 kinase, 90kD Synonym: RPS6KA1,RSK1,p90RSK Accession: P00964 inside PROTEIN p32 Long Name: Mitogen-activated protein kinase-activated protein kinase 2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P00979 inside PROTEIN p34 Long Name: 3'-Phosphoinositide-dependent protein kinase1/2 Synonym: PDK1,PDPK1 Accession: P00985 inside PROTEIN p16 Long Name: 3'-Phosphoinositide-dependent protein kinase1/2 Synonym: PDK1,PDPK1 Accession: P00985 inside PROTEIN p16 Long Name: c-fos Synonym: Synonym not specified Accession: P00967 inside PROTEIN p35 Long Name: c-fos Synonym: Synonym not specified Accession: P00967 inside PROTEIN p35 Long Name: Serum response factor Synonym: SRF Accession: P00987 inside PROTEIN p36 Long Name: Serum response factor Synonym: SRF Accession: P00987 inside PROTEIN p36 Long Name: Gene transcription Synonym: Synonym not specified Accession: U02424 inside PHENOTYPE Gene transcription Long Name: Interleukin Synonym: Synonym not specified Accession: P00970 inside PROTEIN p37 Long Name: Jak Synonym: Synonym not specified Accession: P00978 inside PROTEIN p4 Long Name: Signal transducers and activators of transcription Synonym: STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,family members include STAT1 Accession: P00996 inside PROTEIN p6 2 Long Name: Signal transducers and activators of transcription Synonym: STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,family members include STAT1 Accession: P00996 inside PROTEIN p6 2 Long Name: Signal transducers and activators of transcription Synonym: STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,family members include STAT1 Accession: P00996 inside PROTEIN p6 2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05353 Heterodimer Member Info: Signaling subunit#PROTEIN#Signaling subunit#P00969##;Interleukin#PROTEIN#Interleukin#P00970##;Receptor subunit beta#PROTEIN#Receptor subunit beta#P00974##;Receptor subunit alpha#PROTEIN#Receptor subunit alpha#P00992## transmembrane PROTEIN p1 PROTEIN p3 PROTEIN p2 PROTEIN p37 Long Name: Cyclin-dependent kinase inhibitor 1A Synonym: CDKN1A,p21,p21CIP1,p21WAF1 Accession: P00993 inside PROTEIN p27 Long Name: Protein kinase B Synonym: Akt,PKB Accession: P00973 inside PROTEIN p10 Long Name: Cyclin-dependent kinase inhibitor 1B Synonym: CDKN1B,p27,p27KIP1 Accession: P00982 inside PROTEIN p28 Long Name: Insulin receptor substrate family Synonym: IRS2,IRS3,IRS4,family includes IRS1 Accession: P00980 inside PROTEIN p5 Long Name: Src-like protein tyrosine kinase (PTK) family Synonym: Blk,Bsk),Fgr,Fyn,Gtk,Hck,Lck,Lyn,Rak (Frk,Yes,family includes Src Accession: P00991 inside PROTEIN p20 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05354 Heterodimer Member Info: Grb2#PROTEIN#Growth Factor Receptor Binding Protein 2#P00971#Abundant SRC homology (ASH)|Grb2#;SOS#PROTEIN#Son of Sevenless#P00981#SOS#;Shc#PROTEIN#Shc#P00997## inside PROTEIN p8 PROTEIN p18 PROTEIN p9 Long Name: Jak Synonym: Synonym not specified Accession: P00978 inside PROTEIN p4 Long Name: PI3K Synonym: Synonym not specified Accession: P00990 inside PROTEIN p7 Long Name: Ras Synonym: Synonym not specified Accession: P00977 inside PROTEIN p11 Long Name: ATP Synonym: Synonym not specified Accession: S01747 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01748 inside SIMPLE_MOLECULE ADP Long Name: Pi Synonym: Synonym not specified Accession: U02423 inside ION P_sub_i_endsub_ STATE_TRANSITION s148 s148 0.33333333333333215,-8.881784197001252E-16 0.666666666666667,-1.7763568394002505E-15 a29 a61 a31 a62 a73 STATE_TRANSITION s22 s22 0.3333333333333339,0.0 0.6666666666666661,0.0 a30 a32 a31 STATE_TRANSITION s23 s26 0.3333333333333339,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 a33 a40 a35 a42 a32 STATE_TRANSITION s24 s27 0.33333333333333304,4.440892098500626E-16 0.666666666666667,4.440892098500626E-16 a34 a39 a36 a41 a35 STATE_TRANSITION s30 s31 0.33333333333333304,-2.220446049250313E-15 0.6666666666666661,-3.552713678800501E-15 a43 a45 a44 a46 a137 STATE_TRANSITION s8 s20 0.33333333333333304,2.220446049250313E-15 0.6666666666666665,3.9968028886505635E-15 a14 a53 a28 a55 a222 STATE_TRANSITION s148 s148 0.33333333333333304,0.0 0.6666666666666661,0.0 a31 a29 a63 a64 STATE_TRANSITION s7 s129 0.3333333333333335,-1.7763568394002505E-15 0.6666666666666674,-3.774758283725532E-15 a13 a82 a58 a83 a68 a182 STATE_TRANSITION s47 s131 0.3333333333333335,-2.220446049250313E-16 0.6666666666666665,-6.661338147750939E-16 a67 a80 a68 a81 a67 a182 HETERODIMER_ASSOCIATION s10,s11 s132 0.33333333333333304,6.661338147750939E-16 0.666666666666667,0.0 0.3333333333333335,-8.881784197001252E-16 0.6666666666666665,8.881784197001252E-16 0.3333333333333335,4.440892098500626E-16 0.666666666666667,0.0 0.33333333333333304,0.3333333333333335 a16 a17 a57 a73 a68 a58 a182 STATE_TRANSITION s147 s147 0.3333333333333335,8.881784197001252E-16 0.6666666666666665,8.881784197001252E-16 a92 a15 a58 a182 STATE_TRANSITION s13 s14 0.33333333333333304,0.0 0.666666666666667,0.0 a19 a20 a15 STATE_TRANSITION s32 s33 0.33333333333333304,4.440892098500626E-16 0.6666666666666652,4.440892098500626E-16 a47 a115 a48 a134 a20 STATE_TRANSITION s12 s34 0.33333333333333304,0.0 0.6666666666666661,0.0 a18 a116 a49 a133 a48 STATE_TRANSITION s35 s36 0.3333333333333339,8.881784197001252E-16 0.666666666666667,8.881784197001252E-16 a50 a118 a51 a131 a112 STATE_TRANSITION s54 s61 0.33333333333333215,0.0 0.6666666666666661,-8.881784197001252E-16 a98 a119 a99 a130 a112 TRANSPORT s34 s121 0.33333333333333215,-4.440892098500626E-16 0.6666666666666661,-8.881784197001252E-16 a49 a112 STATE_TRANSITION s57 s64 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666661,0.0 a102 a117 a109 a132 a49 STATE_TRANSITION s55 s62 0.3333333333333339,1.7763568394002505E-15 0.6666666666666687,1.7763568394002505E-15 a100 a120 a106 a129 a112 STATE_TRANSITION s56 s63 0.33333333333333304,8.881784197001252E-16 0.666666666666667,8.881784197001252E-16 a101 a121 a107 a128 a112 STATE_TRANSITION s58 s65 0.33333333333333304,-2.6645352591003757E-15 0.6666666666666679,-4.440892098500626E-15 a103 a122 a108 a127 a112 STATE_TRANSITION s59 s120 0.33333333333333304,0.0 0.666666666666667,0.0 a104 a123 a110 a126 a112 STATE_TRANSITION s60 s71 0.33333333333333215,-3.552713678800501E-15 0.6666666666666661,-1.0658141036401503E-14 a105 a124 a111 a125 a112 TRANSPORT s120 s66 0.33333333333333304,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a110 a113 TRANSPORT s71 s122 0.3333333333333339,8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a111 a114 STATE_TRANSITION s34 s12 0.33333333333333304,3.1086244689504383E-15 0.6666666666666661,6.217248937900877E-15 a49 a18 a136 a135 TRANSPORT s27 s93 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a36 a137 STATE_TRANSITION s81 s83 0.33333333333333304,1.7763568394002505E-15 0.6666666666666665,5.329070518200751E-15 a148 a154 a145 a160 a36 STATE_TRANSITION s80 s84 0.3333333333333326,8.881784197001252E-16 0.6666666666666665,3.552713678800501E-15 a147 a156 a144 a161 a36 STATE_TRANSITION s82 s85 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666665,-3.552713678800501E-15 a149 a155 a146 a162 a36 STATE_TRANSITION s76 s86 0.33333333333333304,-8.881784197001252E-16 0.6666666666666665,-1.7763568394002505E-15 a150 a157 a138 a163 a137 STATE_TRANSITION s77 s87 0.33333333333333304,-5.329070518200751E-15 0.666666666666667,-1.0658141036401503E-14 a151 a158 a139 a164 a137 TRANSPORT s84 s94 0.3333333333333335,0.0 0.666666666666667,4.440892098500626E-16 a144 a152 TRANSPORT s85 s95 0.3333333333333335,-4.440892098500626E-16 0.6666666666666665,-4.440892098500626E-16 a146 a153 STATE_TRANSITION s96 s98 0.33333333333333304,3.552713678800501E-15 0.6666666666666667,1.7763568394002505E-15 a166 a167 a152 STATE_TRANSITION s99 s101 0.33333333333333304,0.0 0.6666666666666665,1.7763568394002505E-15 a168 a169 a153 TRANSCRIPTIONAL_ACTIVATION s98 s102 0.3333333333333339,-4.440892098500626E-16 0.666666666666667,0.0 a167 a170 TRANSCRIPTIONAL_ACTIVATION s101 s102 0.33333333333333304,0.0 0.6666666666666661,-8.881784197001252E-16 a169 a170 TRANSCRIPTIONAL_ACTIVATION s31 s102 0.33333333333333304,-8.881784197001252E-16 0.6666666666666665,-8.881784197001252E-16 a44 a170 TRANSCRIPTIONAL_ACTIVATION s86 s102 0.3333333333333335,0.0 0.6666666666666665,-8.881784197001252E-16 a138 a170 TRANSCRIPTIONAL_ACTIVATION s87 s102 0.33333333333333326,0.0 0.6666666666666667,0.0 a139 a170 STATE_TRANSITION s20 s113 0.3333333333333337,4.440892098500626E-16 0.6666666666666667,8.881784197001252E-16 a28 a173 TRANSPORT s113 s115 0.3333333333333337,-1.1102230246251565E-16 0.6666666666666667,-3.3306690738754696E-16 a173 a175 STATE_TRANSITION s115 s116 0.3333333333333339,-5.551115123125783E-17 0.666666666666667,-2.7755575615628914E-17 a175 a159 a176 a165 a137 HETERODIMER_ASSOCIATION s2,s5 s119 0.3192733305475517,0.0553417221795891 0.6628148076088953,0.1021205148589488 0.3333333333333335,4.440892098500626E-16 0.6666666666666665,2.220446049250313E-16 0.33333333333333326,-3.885780586188048E-16 0.6666666666666665,-7.216449660063518E-16 -2.0780286502483154,0.8871113765208887 a2 a8 a171 a3 a182 STATE_TRANSITION s104 s125 0.3333333333333333,5.773159728050814E-15 0.6666666666666667,1.1546319456101628E-14 a12 a52 a222 a54 a182 a12 TRANSCRIPTIONAL_ACTIVATION s116 s102 0.3333333333333339,-1.7763568394002505E-15 0.666666666666667,-1.7763568394002505E-15 a176 a170