2.2 SQUARE_CLOSEUP_NORTHEAST SQUARE inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive ER cytosol Long Name: Glutamate Synonym: Synonym not specified Accession: S01769 inside SIMPLE_MOLECULE Glutamate Long Name: 1,4,5-Trisphosphate Synonym: Synonym not specified Accession: S01772 inside SIMPLE_MOLECULE IP_sub_3 Long Name: Ca2+ Synonym: Synonym not specified Accession: U02476 inside ION Ca_super_2+ Long Name: GTP Synonym: Synonym not specified Accession: S01771 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01774 inside SIMPLE_MOLECULE GDP Long Name: Phosphatidylinositol-4,5-bisphosphate Synonym: Synonym not specified Accession: S01770 inside SIMPLE_MOLECULE PIP2 Long Name: Diacylglycerol Synonym: Synonym not specified Accession: S01773 inside SIMPLE_MOLECULE DAG Long Name: Ca2+ Synonym: Synonym not specified Accession: U02476 inside ION Ca_super_2+ Long Name: Protein Kinase A Synonym: PKA Accession: P01059 inside PROTEIN p5 Long Name: inositol 1,4,5-triphosphate receptor Synonym: ITPR Accession: P01056 transmembrane PROTEIN p4 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05384 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01771##;G-Protein#PROTEIN#Gq#P01057## inside SIMPLE_MOLECULE GTP PROTEIN p8 Long Name: Phospholipase C Synonym: PLC Accession: P01053 inside PROTEIN p2 Long Name: Protein kinase C Synonym: PKC Accession: P01055 inside PROTEIN p9 Long Name: Homer Synonym: Synonym not specified Accession: P01058 inside PROTEIN p10 Long Name: Metabotropic glutamate receptor 1 Synonym: mGlu 1,mGlu1,mGluR1 Accession: P01062 transmembrane PROTEIN p11 Long Name: metabotropic glutamate receptor 5 Synonym: GRM5,mGlu 5,mGlu5,mGluR5 Accession: P01061 transmembrane PROTEIN p12 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05392 Heterodimer Member Info: Homer#PROTEIN#Homer#P01058##;mGluR1#PROTEIN#Metabotropic glutamate receptor 1#P01062#mGlu 1|mGlu1|mGluR1# transmembrane PROTEIN p11 2 PROTEIN p10 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05386 Heterodimer Member Info: Homer#PROTEIN#Homer#P01058##;mGluR5#PROTEIN#metabotropic glutamate receptor 5#P01061#GRM5|mGlu 5|mGlu5|mGluR5# transmembrane PROTEIN p12 2 PROTEIN p10 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05385 Heterodimer Member Info: G-Protein#PROTEIN#Gq#P01057##;GDP#SIMPLE_MOLECULE#GDP#S01774## inside PROTEIN p8 SIMPLE_MOLECULE GDP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05388 Heterodimer Member Info: G-Protein#PROTEIN#Gq#P01057##;Homer#PROTEIN#Homer#P01058##;mGluR5#PROTEIN#metabotropic glutamate receptor 5#P01061#GRM5|mGlu 5|mGlu5|mGluR5#;mGluR1#PROTEIN#Metabotropic glutamate receptor 1#P01062#mGlu 1|mGlu1|mGluR1#;GDP#SIMPLE_MOLECULE#GDP#S01774## transmembrane PROTEIN p11 PROTEIN p12 PROTEIN p10 PROTEIN p8 SIMPLE_MOLECULE GDP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05387 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01769##;Homer#PROTEIN#Homer#P01058##;mGluR5#PROTEIN#metabotropic glutamate receptor 5#P01061#GRM5|mGlu 5|mGlu5|mGluR5#;mGluR1#PROTEIN#Metabotropic glutamate receptor 1#P01062#mGlu 1|mGlu1|mGluR1# transmembrane PROTEIN p11 PROTEIN p12 SIMPLE_MOLECULE Glutamate PROTEIN p10 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05391 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01769##;G-Protein#PROTEIN#Gq#P01057##;Homer#PROTEIN#Homer#P01058##;mGluR5#PROTEIN#metabotropic glutamate receptor 5#P01061#GRM5|mGlu 5|mGlu5|mGluR5#;mGluR1#PROTEIN#Metabotropic glutamate receptor 1#P01062#mGlu 1|mGlu1|mGluR1#;GDP#SIMPLE_MOLECULE#GDP#S01774## transmembrane PROTEIN p11 PROTEIN p12 SIMPLE_MOLECULE Glutamate PROTEIN p10 PROTEIN p8 SIMPLE_MOLECULE GDP Long Name: Kainate Receptor Synonym: Glu5,GluR5,KA Receptor Accession: P01054 transmembrane PROTEIN p6 Long Name: N-methyl-D-aspartate Receptor Synonym: Synonym not specified Accession: P01060 transmembrane PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05390 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01769##;NMDA#PROTEIN#N-methyl-D-aspartate Receptor#P01060## transmembrane PROTEIN p7 SIMPLE_MOLECULE Glutamate Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05389 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01769##;GluR5#PROTEIN#Kainate Receptor#P01054#Glu5|GluR5|KA Receptor# transmembrane PROTEIN p6 SIMPLE_MOLECULE Glutamate DISSOCIATION s13 s14,s15 0.33333333333333215,0.0 0.6666666666666645,0.0 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666661,-1.7763568394002505E-15 0.3333333333333357,0.0 0.6666666666666643,0.0 0.4354581648691984,0.1831749411499608 a13 a14 a15 TRANSPORT s47 s18 0.3333333333333335,0.0 0.666666666666667,0.0 a17 a18 STATE_TRANSITION s61 s61 0.33333333333333304,0.0 0.6666666666666661,-8.881784197001252E-16 a68 a69 STATE_TRANSITION s48 s48 0.33333333333333304,8.881784197001252E-16 0.6666666666666661,8.881784197001252E-16 a67 a53 STATE_TRANSITION s60 s60 0.33333333333333215,-8.881784197001252E-16 0.6666666666666661,-1.7763568394002505E-15 a11 a66 HETERODIMER_ASSOCIATION s63,s37 s66 0.33333333333333304,0.0 0.6666666666666661,4.440892098500626E-16 0.33333333333333304,-1.1102230246251565E-16 0.6666666666666665,1.1102230246251565E-16 0.3333333333333335,4.440892098500626E-16 0.6666666666666665,0.0 0.33333333333333304,0.33333333333333326 a71 a49 a74 HETERODIMER_ASSOCIATION s64,s37 s70 0.33333333333333304,1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 0.3333333333333337,2.220446049250313E-16 0.666666666666667,0.0 0.3333333333333335,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 0.33333333333333326,0.3333333333333326 a72 a49 a80 HETERODIMER_ASSOCIATION s63,s64 s77 0.3333333333333335,2.220446049250313E-16 0.6666666666666667,4.440892098500626E-16 0.33333333333333215,1.7763568394002505E-15 0.6666666666666696,1.7763568394002505E-15 0.3333333333333335,-1.1102230246251565E-16 0.7020692649580589,0.012294918579518033 0.33333333333333215,0.33333333333333304 a71 a72 a86 a49 a90 HETERODIMER_ASSOCIATION s4,s77 s94 0.33333333333333304,8.881784197001252E-16 0.6666666666666665,-8.881784197001252E-16 0.3333333333333335,8.881784197001252E-16 0.666666666666667,0.0 0.33333333333333304,1.6653345369377348E-16 0.666666666666667,1.6653345369377348E-16 0.3333333333333335,0.3333333333333335 a4 a90 a112 DISSOCIATION s94 s59,s86 0.3333333333333339,8.881784197001252E-16 0.6666666666666687,-4.440892098500626E-16 0.3333333333333329,0.0 0.6666666666666664,0.0 0.33333333333333304,0.0 0.6666666666666661,-8.881784197001252E-16 0.33333333333333326,0.33333333333333304 a112 a19 a65 a100 a75 STATE_TRANSITION s16 s16 0.3333333333333335,-2.6645352591003757E-15 0.6666666666666667,-4.440892098500626E-15 a16 a57 STATE_TRANSITION s98 s100 0.35454513867667536,-0.0435838283392318 0.6666666666666661,0.0 a114 a119 a118 STATE_TRANSITION s97 s103 0.058666345804727627,-0.10014556634634975 0.6666666666666661,-4.440892098500626E-16 a116 a119 a123