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<![CDATA[
Muscarinic Acetylcholine Receptor 2, 4 Pathway: Muscarinic ACh receptors are negatively coupled to PKA and intracellular cAMP signaling.
These receptors are found in the brain controlling attention (eg. reduction of cholinergic fibers in elderly and trisomy 21 patients leads to Alzheimer's disease) and peripheral nervous system controlling parasympathetic responses (eg. release of acetylcholine from the vagus nerve reduces heart rate and blood pressure).
These receptors are important existing drug targets for heart disease, hypertension, bronchial asthma, anesthesia, Alzheimer's disease, and one of the main mechanisms for dilated cardiomyopathy is likely to be autoimmune (against m2) mediated myocardial damage.
Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12667888
Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9711178
Website=http://www.ptd.neu.edu/neuroanatomy/cyberclass/pharmacology/acetylcholine.htm
Website=http://www.unifr.ch/biochem/DREYER/Neurotransmitters/acetylcholine.htm
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Heterodimer Member Info:  GTP#SIMPLE_MOLECULE#GTP#S01787##;G-Protein#PROTEIN#Gi#P01085##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r44"/>
<celldesigner:catalyzed reaction="r71"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s4" initialAmount="0.0" name="ACh">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ACh
Synonym:  Synonym not specified
Accession:  S01783
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ACh</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c6" id="s68" initialAmount="0.0" name="SNARE COMPLEX">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  N-ethylmaleimide-sensitive factor attachment protein receptor
Synonym:  SNARE
Accession:  P01079
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c6" id="s69" initialAmount="0.0" name="ACh">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ACh
Synonym:  Synonym not specified
Accession:  S01783
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ACh</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s70" initialAmount="0.0" name="CAT">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  choline acetyltransferase
Synonym:  CAT,CHAT
Accession:  P01076
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r56"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c5" id="s72" initialAmount="0.0" name="choline">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  choline
Synonym:  Synonym not specified
Accession:  S01786
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>choline</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s71" initialAmount="0.0" name="Acetyl CoA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Acetyl CoA
Synonym:  Synonym not specified
Accession:  S01789
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Acetyl CoA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s73" initialAmount="0.0" name="ACh">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ACh
Synonym:  Synonym not specified
Accession:  S01783
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ACh</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s77" initialAmount="0.0" name="AChE">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  acetylcholinesterase
Synonym:  ACHE,AChE
Accession:  P01080
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r59"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s79" initialAmount="0.0" name="Acetyl CoA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Acetyl CoA
Synonym:  Synonym not specified
Accession:  S01789
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Acetyl CoA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s80" initialAmount="0.0" name="choline">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  choline
Synonym:  Synonym not specified
Accession:  S01786
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>choline</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s83" initialAmount="0.0" name="CHT1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  high affinity choline transporter
Synonym:  cht1
Accession:  P01084
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p14</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s58" initialAmount="0.0" name="Complex(GDP/G-Protein/mAChR2/4)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  cholinergic receptor, muscarinic 1, cholinergic receptor, muscarinic 3
Synonym:  Synonym not specified
Accession:  U05402
Heterodimer Member Info:  mAChR2/4#PROTEIN#mAChR2/4#P01077#CHRM2|CHRM4|mACh2|mACh4|mAChR2|mAChR4#;GDP#SIMPLE_MOLECULE#GDP#S01784##;G-Protein#PROTEIN#Gi#P01085##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c2" id="s65" initialAmount="0.0" name="Complex(mAChR2/4/ACh)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05398
Heterodimer Member Info:  ACh#SIMPLE_MOLECULE#ACh#S01783##;mAChR2/4#PROTEIN#mAChR2/4#P01077#CHRM2|CHRM4|mACh2|mACh4|mAChR2|mAChR4#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ACh</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c2" id="s84" initialAmount="0.0" name="ATP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S01785
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s85" initialAmount="0.0" name="cAMP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  cAMP
Synonym:  Synonym not specified
Accession:  S01788
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cAMP</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r68"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c2" id="s92" initialAmount="0.0" name="GIRK">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  G protein-coupled inwardly rectifying potassium channel
Synonym:  GIRK
Accession:  P01083
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p16</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r73"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s94" initialAmount="0.0" name="K_super_+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+
Synonym:  Synonym not specified
Accession:  U02490
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>K_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s95" initialAmount="0.0" name="K_super_+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  K+
Synonym:  Synonym not specified
Accession:  U02490
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>K_super_+</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c6" id="s96" initialAmount="0.0" name="VAChT">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  vesicular acetylcholine transporter
Synonym:  CG32848,VAChT
Accession:  P01078
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p17</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s97" initialAmount="0.0" name="muscle contraction">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  muscle contraction
Synonym:  Synonym not specified
Accession:  U02491
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>muscle contraction</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s60" initialAmount="0.0" name="AC">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Adenylate Cyclase
Synonym:  AC
Accession:  P01082
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r67"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c2" id="s88" initialAmount="0.0" name="PKA">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Protein Kinase A
Synonym:  PKA
Accession:  P01075
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r69"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c6" id="s99" initialAmount="0.0" name="Complex(VAChT/ACh)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05399
Heterodimer Member Info:  ACh#SIMPLE_MOLECULE#ACh#S01783##;VAChT#PROTEIN#vesicular acetylcholine transporter#P01078#CG32848|VAChT#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p17</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ACh</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c5" id="s102" initialAmount="0.0" name="Complex(CHT1/choline)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05401
Heterodimer Member Info:  choline#SIMPLE_MOLECULE#choline#S01786##;CHT1#PROTEIN#high affinity choline transporter#P01084#cht1#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p14</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>choline</celldesigner:name>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c2" id="s66" initialAmount="0.0" name="Ca_super_2+">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  L-type Calcium Channel
Synonym:  Ca2+ channel
Accession:  P01081
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r70"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="r44" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s60</celldesigner:baseReactants>
<celldesigner:baseProducts>s60</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333339,-1.7763568394002505E-15 0.666666666666667,-3.552713678800501E-15</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a65" editPoints="0.3333333333333326,-1.7763568394002505E-15 0.6666666666666665,0.0" modifiers="s59" targetLineIndex="-1,1" type="INHIBITION"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s60">
<annotation>
<celldesigner:alias>a11</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s60">
<annotation>
<celldesigner:alias>a66</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s59">
<annotation>
<celldesigner:alias>a65</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r53" reversible="false">
<annotation>
<celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s58</celldesigner:baseReactants>
<celldesigner:baseProducts>s65,s59</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a19" reactant="s19" targetLineIndex="0,2"/>
<celldesigner:reactantLink alias="a4" reactant="s4" targetLineIndex="0,0"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a23" product="s20" targetLineIndex="0,2"/>
</celldesigner:listOfProductLinks>
<celldesigner:offset x="11.0" y="-29.0"/>
<celldesigner:editPoints>0.4493850103200878,-0.09287121859547498 0.831157121680016,-0.04416882830268676 0.33333333333333215,-4.440892098500626E-16 0.6666666666666661,0.0 0.3333333333333335,-3.0531133177191805E-16 0.6666666666666661,-5.273559366969494E-16 0.1601708338333565,0.4743435020451461</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s58">
<annotation>
<celldesigner:alias>a64</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s19">
<annotation>
<celldesigner:alias>a19</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s4">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
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