<?xml version="1.0" encoding="UTF-8"?>
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<!--Notes by CellDesigner-->
<body>
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<!--Notes by CellDesigner-->
<body>
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<species compartment="c2" id="s9" name="dynorphin A">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  dynorphin A
Synonym:  Synonym not specified
Accession:  P04514
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p22</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s10" name="prodynorphin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  prodynorphin
Synonym:  Synonym not specified
Accession:  G04678
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>prodynorphin</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s11" name="prodynorphin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  prodynorphin
Synonym:  Synonym not specified
Accession:  G04677
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:name>prodynorphin</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s12" name="dehydration or salt loading stress">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  dehydration or salt loading stress
Synonym:  Synonym not specified
Accession:  U05429
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>dehydration or salt loading stress</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re6"/>
<celldesigner:catalyzed reaction="re11"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c3" id="s15" name="vasopressin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  vasopressin
Synonym:  ADH,antidiuretic hormone
Accession:  P04515
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s16" name="vasopressin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  vasopressin
Synonym:  ADH,antidiuretic hormone
Accession:  P04515
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s17" name="vasopressin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  vasopressin
Synonym:  ADH,antidiuretic hormone
Accession:  P04515
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s13" name="prepropressophysin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  prepropressophysin
Synonym:  Synonym not specified
Accession:  G04680
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:name>prepropressophysin</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c4" id="s14" name="prepropressophysin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  prepropressophysin
Synonym:  Synonym not specified
Accession:  G04679
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:name>prepropressophysin</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s18" name="antidiuretic effects">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  antidiuretic effects
Synonym:  Synonym not specified
Accession:  U05428
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>antidiuretic effects</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s20" name="opium">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  opium
Synonym:  Synonym not specified
Accession:  S04823
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>opium</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s22" name="Complex(GTP/G-protein)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05427
Heterodimer Member Info:  GTP#SIMPLE_MOLECULE#GTP#S04826##;G-protein#PROTEIN#G-protein#P04517##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re20"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c5" id="s23" name="GDP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GDP
Synonym:  Synonym not specified
Accession:  S04824
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s25" name="GTP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S04826
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s26" name="ATP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S04825
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s28" name="cAMP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  cAMP
Synonym:  Synonym not specified
Accession:  S04827
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cAMP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s45" name="neoendorphin (alpha and beta)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  neoendorphin (alpha and beta)
Synonym:  Synonym not specified
Accession:  P04519
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p21</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s31" name="Complex(GDP/G-protein/Sigma Receptor)">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05425
Heterodimer Member Info:  GDP#SIMPLE_MOLECULE#GDP#S04824##;G-protein#PROTEIN#G-protein#P04517##;Sigma Receptor#PROTEIN#Sigma Receptor#P04518#opioid receptor#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c5" id="s32" name="AC">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  AC
Synonym:  adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase
Accession:  P04516
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re19"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s51" name="endorphins">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  endorphins (morphine like)
Synonym:  Synonym not specified
Accession:  P04513
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c5" id="s54" name="Complex(Sigma Receptor/endorphins (morphine like))">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05424
Heterodimer Member Info:  endorphins (morphine like)#PROTEIN#endorphins (morphine like)#P04513##;Sigma Receptor#PROTEIN#Sigma Receptor#P04518#opioid receptor#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c5" id="s57" name="Complex(GDP/G-protein/Sigma Receptor/endorphins (morphine like))">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05426
Heterodimer Member Info:  GDP#SIMPLE_MOLECULE#GDP#S04824##;endorphins (morphine like)#PROTEIN#endorphins (morphine like)#P04513##;G-protein#PROTEIN#G-protein#P04517##;Sigma Receptor#PROTEIN#Sigma Receptor#P04518#opioid receptor#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="re1" reversible="false">
<annotation>
<celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s4</celldesigner:baseReactants>
<celldesigner:baseProducts>s9,s45</celldesigner:baseProducts>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a4" product="s8" targetLineIndex="0,0"/>
</celldesigner:listOfProductLinks>
<celldesigner:offset x="-22.0" y="1.0"/>
<celldesigner:editPoints>0.33333333333333326,0.0 0.6666666666666663,-8.881784197001252E-16 0.3333333333333348,-4.440892098500626E-16 0.666666666666667,-8.881784197001252E-16 0.3333333333333326,0.0 0.6666666666666665,8.881784197001252E-16 0.33333333333333304,0.3333333333333339</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s4">
<annotation>
<celldesigner:alias>a6</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s9">
<annotation>
<celldesigner:alias>a5</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s45">
<annotation>
<celldesigner:alias>a3</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s8">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re3" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>s45</celldesigner:baseReactants>
<celldesigner:baseProducts>s5</celldesigner:baseProducts>
<celldesigner:offset x="-22.0" y="-6.0"/>
<celldesigner:editPoints>0.3333333333333335,0.0 0.6666666666666665,-4.440892098500626E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a2" editPoints="0.33333333333333126,0.0 0.6666666666666687,0.0" modifiers="s1" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s45">
<annotation>
<celldesigner:alias>a3</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s5">
<annotation>
<celldesigner:alias>a7</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s1">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re4" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>s8</celldesigner:baseReactants>
<celldesigner:baseProducts>s2</celldesigner:baseProducts>
<celldesigner:offset x="0.0" y="-1.0"/>
<celldesigner:editPoints>0.36098231277395465,-0.0033261114035696426 0.5509390376230114,-0.01143038805815011</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a2" editPoints="0.3333333333333335,0.0 0.666666666666667,0.0" modifiers="s1" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s8">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s2">
<annotation>
<celldesigner:alias>a9</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s1">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re5" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>s9</celldesigner:baseReactants>
<celldesigner:baseProducts>s3</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333326,0.0 0.6666666666666665,-2.220446049250313E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a2" editPoints="0.3333333333333335,-4.440892098500626E-16 0.6666666666666661,4.440892098500626E-16" modifiers="s1" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s9">
<annotation>
<celldesigner:alias>a5</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s3">
<annotation>
<celldesigner:alias>a8</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s1">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="re6" reversible="false">
<annotation>
<celldesigner:reactionType>TRANSCRIPTIONAL_ACTIVATION</celldesigner:reactionType>
<celldesigner:baseReactants>s10</celldesigner:baseReactants>
<celldesigner:baseProducts>s11</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333335,0.0 0.666666666666667,-5.551115123125783E-17</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a12" editPoints="0.33333333333333326,1.7763568394002505E-15 0.6666666666666666,3.608224830031759E-15" modifiers="s12" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s10">
<annotation>
<celldesigner:alias>a10</celldesigner:alias>
</annotation>
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</model>
</sbml>


