2.3 SQUARE SQUARE SQUARE_CLOSEUP_SOUTH SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive Golgi apparatus synaptic vesicle neurons of nucleus tractus solitarius (also in anterior pituitary, neocortex, basal ganglia, amygldala) noxious stimuli sensitive cells around the central canal in spinal cord Long Name: beta-Endorphin Synonym: Synonym not specified Accession: P04523 inside PROTEIN p16 Long Name: stress response Synonym: Synonym not specified Accession: U05438 inside PHENOTYPE stress response Long Name: SNARE COMPLEX Synonym: Synonym not specified Accession: P04525 transmembrane PROTEIN p24 Long Name: ACTH Synonym: Corticotropin Accession: P04521 inside PROTEIN p17 Long Name: proopiomelanocortin Synonym: Corticotropin,Gamma-MSH,Lipotropin,Melanocyte stimulating hormone,Melanotropin,POC Accession: P04522 inside PROTEIN p12 Long Name: beta-Endorphin Synonym: Synonym not specified Accession: P04523 inside PROTEIN p16 Long Name: ACTH Synonym: Corticotropin Accession: P04521 inside PROTEIN p17 Long Name: alpha-MSH Synonym: Synonym not specified Accession: P04526 inside PROTEIN p18 Long Name: alpha-MSH Synonym: Synonym not specified Accession: P04526 inside PROTEIN p18 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05433 Heterodimer Member Info: G-protein#PROTEIN#G-protein#P04524##;GTP#SIMPLE_MOLECULE#GTP#S04830## inside SIMPLE_MOLECULE GTP PROTEIN p11 Long Name: GTP Synonym: Synonym not specified Accession: S04830 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S04831 inside SIMPLE_MOLECULE GDP Long Name: cAMP Synonym: Synonym not specified Accession: S04829 inside SIMPLE_MOLECULE cAMP Long Name: ATP Synonym: Synonym not specified Accession: S04828 inside SIMPLE_MOLECULE ATP Long Name: AC Synonym: adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase Accession: P04529 inside PROTEIN p7 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05430 Heterodimer Member Info: G-protein#PROTEIN#G-protein#P04524##;Mu or Kappa#PROTEIN#Mu or Kappa#P04528#Kappa receptor|Mu receptor|Opioid receptor#;GDP#SIMPLE_MOLECULE#GDP#S04831## transmembrane SIMPLE_MOLECULE GDP PROTEIN p11 PROTEIN p6 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05432 Heterodimer Member Info: beta-Endorphin#PROTEIN#beta-Endorphin#P04523##;G-protein#PROTEIN#G-protein#P04524##;Mu or Kappa#PROTEIN#Mu or Kappa#P04528#Kappa receptor|Mu receptor|Opioid receptor#;GDP#SIMPLE_MOLECULE#GDP#S04831## transmembrane SIMPLE_MOLECULE GDP PROTEIN p11 PROTEIN p6 PROTEIN p16 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05431 Heterodimer Member Info: beta-Endorphin#PROTEIN#beta-Endorphin#P04523##;Mu or Kappa#PROTEIN#Mu or Kappa#P04528#Kappa receptor|Mu receptor|Opioid receptor# transmembrane PROTEIN p6 PROTEIN p16 Long Name: K+ Synonym: Synonym not specified Accession: U05435 inside ION K+ Long Name: K+ Synonym: Synonym not specified Accession: U05435 inside ION K+ Long Name: Long name not specified Synonym: Synonym not specified Accession: U05434 Heterodimer Member Info: hyperpolarization#PHENOTYPE#hyperpolarization#U05436##;Anaelgesia#PHENOTYPE#Anaelgesia#U05437## inside PHENOTYPE Anaelgesia PHENOTYPE hyperpolarization Long Name: K+ channel Synonym: Kcnk3,Potassium channel subfamily K member 3,Potassium channel subfamily K member 9,TASK-1,TASK-3,TWIK Accession: P04527 transmembrane PROTEIN p2 DISSOCIATION s2 s5,s4 0.3333333333333335,-2.220446049250313E-16 0.6666666666666666,0.0 0.33333333333333337,0.0 0.6666666666666667,4.440892098500626E-16 0.33333333333333304,2.220446049250313E-16 0.6666666666666661,2.220446049250313E-16 0.33333333333333326,0.33333333333333326 a9 a8 a7 a6 TRANSPORT s5 s39 0.4725020229761573,-0.014260806661154035 0.8492524953011932,-0.033446071139298095 a8 a5 a3 TRANSPORT s3 s40 0.3333333333333335,-1.1102230246251565E-16 0.7380130753062568,-4.6953827741935683E-4 a6 a4 a3 KNOWN_TRANSITION_OMITTED s40 s41 0.33333333333333304,0.0 0.666666666666667,4.440892098500626E-16 a4 a2 KNOWN_TRANSITION_OMITTED s39 s41 0.33333333333333304,-1.1102230246251565E-16 0.666666666666667,0.0 a5 a2 TRANSPORT s4 s43 0.33333333333333337,-1.1102230246251565E-16 0.6666666666666666,-1.1102230246251565E-16 a7 a1 a3 STATE_TRANSITION s15 s12 0.33333333333333304,-4.440892098500626E-16 0.6666666666666679,-4.440892098500626E-16 a19 a16 a17 STATE_TRANSITION s18 s18 0.33333333333333304,8.881784197001252E-16 0.6666666666666661,8.881784197001252E-16 a18 a17 a11 STATE_TRANSITION s31 s31 0.3333333333333335,0.0 0.6666666666666669,8.881784197001252E-16 a36 a35 a11 TRANSPORT s32 s30 0.3333333333333339,0.0 0.666666666666667,0.0 a37 a34 a35 STATE_TRANSITION s31 s35 0.3333333333333339,-1.3877787807814457E-16 0.666666666666667,-3.0531133177191805E-16 a35 a40 KNOWN_TRANSITION_OMITTED s12 s35 0.33333333333333304,4.440892098500626E-16 0.6666666666666665,6.661338147750939E-16 a16 a40 HETERODIMER_ASSOCIATION s43,s11 s26 0.3333333333333339,4.440892098500626E-16 0.6666666666666679,0.0 0.3333333333333339,-4.440892098500626E-16 0.666666666666667,-1.3322676295501878E-15 0.3333333333333329,0.0 0.6666666666666677,-1.7763568394002505E-15 0.3333333333333335,0.33333333333333276 a1 a15 a32 DISSOCIATION s26 s27,s7 0.3333333333333335,-4.440892098500626E-16 0.6666666666666665,-4.440892098500626E-16 0.33333333333333215,2.220446049250313E-16 0.6666666666666679,-6.661338147750939E-16 0.3333333333333329,0.0 0.6666666666666666,0.0 0.33333333333333215,0.33333333333333304 a32 a13 a33 a11 a14