2.2 SQUARE_CLOSEUP_NORTH OVAL OVAL OVAL OVAL inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Intracellular Mitochondrion Synaptic vesicle Endoplasmic reticulum Long Name: Dopamine transporter Synonym: Synonym not specified Accession: P01228 transmembrane PROTEIN p2 Long Name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Synonym: Synonym not specified Accession: S01823 inside SIMPLE_MOLECULE MPTP Long Name: 1-Methyl-4-phenyl pyridium Synonym: Synonym not specified Accession: S01822 inside SIMPLE_MOLECULE MPP+ Long Name: 1-Methyl-4-phenyl pyridium Synonym: Synonym not specified Accession: S01822 inside SIMPLE_MOLECULE MPP+ Long Name: Dopamine Synonym: Synonym not specified Accession: S01819 inside SIMPLE_MOLECULE DA Long Name: Dopamine Synonym: Synonym not specified Accession: S01819 inside SIMPLE_MOLECULE DA Long Name: ONOO- Synonym: Synonym not specified Accession: U02570 inside ION ONOO- Long Name: Reactive oxygen species Synonym: Synonym not specified Accession: S01815 inside SIMPLE_MOLECULE ROS Long Name: Iron Synonym: Synonym not specified Accession: S01818 inside SIMPLE_MOLECULE Iron Long Name: Long Name: Hydrogen peroxide Synonym: Synonym not specified Accession: S04839 inside SIMPLE_MOLECULE H_sub_2_endsub_O_sub_2_endsub Long Name: Phospholipase D2 Synonym: Synonym not specified Accession: P01207 transmembrane PROTEIN p4 Long Name: Casein kinase I Synonym: Synonym not specified Accession: P01242 inside PROTEIN p5 Long Name: Casein kinase II Synonym: Synonym not specified Accession: P01236 inside PROTEIN p6 Long Name: G-protein related kinase Synonym: Synonym not specified Accession: P01234 inside PROTEIN p7 Long Name: 20S proteasome Synonym: Synonym not specified Accession: P01227 inside PROTEIN p11 Long Name: a1_degraded Synonym: Synonym not specified Accession: U02580 inside DEGRADED a1_degraded Long Name: alpha-Synuclein Synonym: Synonym not specified Accession: P01218 inside PROTEIN p1 Long Name: alpha-Synuclein Synonym: Synonym not specified Accession: P01218 inside PROTEIN p1 8 Long Name: alpha-Synuclein Synonym: Synonym not specified Accession: P01218 inside PROTEIN p1 8 Long Name: alpha-Synuclein Synonym: Synonym not specified Accession: P01218 inside PROTEIN p1 Long Name: alpha-Synuclein Synonym: Synonym not specified Accession: P01218 inside PROTEIN p1 Long Name: Ubiquitin C-terminal hydrolase-L1 Synonym: Synonym not specified Accession: P01210 inside PROTEIN p14 Long Name: Synphilin Synonym: Synonym not specified Accession: P01225 inside PROTEIN p12 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05484 Heterodimer Member Info: alpha-Synuclein#PROTEIN#alpha-Synuclein#P01218##;Synphilin#PROTEIN#Synphilin#P01225## inside PROTEIN p12 PROTEIN p1 Long Name: 14-3-3 Synonym: Synonym not specified Accession: P01238 inside PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05493 Heterodimer Member Info: alpha-Synuclein#PROTEIN#alpha-Synuclein#P01218##;14-3-3#PROTEIN#14-3-3#P01238## inside PROTEIN p16 PROTEIN p1 Long Name: alpha-Synuclein Synonym: Synonym not specified Accession: P01218 inside PROTEIN p1 Long Name: Fyn kinase Synonym: Synonym not specified Accession: P01235 inside PROTEIN p17 Long Name: Rous sarcoma protein tyrosine kinase Synonym: Synonym not specified Accession: P01230 inside PROTEIN p18 Long Name: 19S proteasome Synonym: Synonym not specified Accession: P01209 inside PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05495 Heterodimer Member Info: 19S proteasome#PROTEIN#19S proteasome#P01209##;20S proteasome#PROTEIN#20S proteasome#P01227## inside PROTEIN p9 PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05485 Heterodimer Member Info: 19S proteasome#PROTEIN#19S proteasome#P01209##;alpha-Synuclein#PROTEIN#alpha-Synuclein#P01218## inside PROTEIN p9 PROTEIN p1 Long Name: Elk-1 Synonym: Synonym not specified Accession: P01233 inside PROTEIN p19 Long Name: Elk-1 Synonym: Synonym not specified Accession: P01233 inside PROTEIN p19 Long Name: Fatty acids Synonym: Synonym not specified Accession: S01821 inside SIMPLE_MOLECULE Fatty acids Long Name: Long Name: O2 Synonym: Synonym not specified Accession: U05501 inside ION O_sub_2_endsub Long Name: Heat shock protein 70 Synonym: Synonym not specified Accession: P01208 inside PROTEIN p21 Long Name: beta-Synuclein Synonym: Synonym not specified Accession: P01217 inside PROTEIN p22 Long Name: gamma-Synuclein Synonym: Synonym not specified Accession: P01231 inside PROTEIN p23 Long Name: Torsin A Synonym: Synonym not specified Accession: P01221 inside PROTEIN p24 Long Name: Parkin Synonym: Synonym not specified Accession: P01216 inside PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05496 Heterodimer Member Info: Parkin#PROTEIN#Parkin#P01216##;Synphilin#PROTEIN#Synphilin#P01225## inside PROTEIN p12 PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05482 Heterodimer Member Info: Parkin#PROTEIN#Parkin#P01216##;Synphilin#PROTEIN#Synphilin#P01225## inside PROTEIN p12 PROTEIN p13 Long Name: a92_degraded Synonym: Synonym not specified Accession: U02572 inside DEGRADED a92_degraded Long Name: ubiquitin-conjugating enzyme E2L3 Synonym: Synonym not specified Accession: P01224 inside PROTEIN p15 Long Name: ubiquitin-conjugating enzyme E2E2 Synonym: Synonym not specified Accession: P01223 inside PROTEIN p25 Long Name: Ub Synonym: Synonym not specified Accession: U02576 inside ION Ub Long Name: alpha-Synuclein Synonym: Synonym not specified Accession: P01218 inside PROTEIN p1 Long Name: ERK Synonym: MAPK Accession: P01211 inside PROTEIN p26 Long Name: ERK Synonym: MAPK Accession: P01211 inside PROTEIN p26 Long Name: Stress-activated protein kinase Synonym: JNK Accession: P01219 inside PROTEIN p20 Long Name: Stress-activated protein kinase Synonym: JNK Accession: P01219 inside PROTEIN p20 Long Name: p38 MAPK Synonym: Synonym not specified Accession: P01212 inside PROTEIN p27 Long Name: p38 MAPK Synonym: Synonym not specified Accession: P01212 inside PROTEIN p27 Long Name: Endothelin receptor type B-like Synonym: EDNRBL,Gpr37 Accession: P01229 innerSurface PROTEIN p28 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05490 Heterodimer Member Info: Parkin#PROTEIN#Parkin#P01216##;Pael-R#PROTEIN#Endothelin receptor type B-like#P01229#EDNRBL|Gpr37# transmembrane PROTEIN p13 PROTEIN p28 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05494 Heterodimer Member Info: Parkin#PROTEIN#Parkin#P01216##;Pael-R#PROTEIN#Endothelin receptor type B-like#P01229#EDNRBL|Gpr37# inside PROTEIN p13 PROTEIN p28 Long Name: Ubiquitin-conjugating enzyme 6 Synonym: Synonym not specified Accession: P01222 inside PROTEIN p29 Long Name: Ubiquitin-conjugating enzyme 7 Synonym: Synonym not specified Accession: P01220 inside PROTEIN p30 Long Name: a109_degraded Synonym: Synonym not specified Accession: U02582 inside DEGRADED a109_degraded Long Name: Cyclin E Synonym: Synonym not specified Accession: P01213 inside PROTEIN p31 Long Name: Long Name: F-box and WD-40 domain protein 7 Synonym: Synonym not specified Accession: U05483 Heterodimer Member Info: Parkin#PROTEIN#Parkin#P01216##;Cul-1#PROTEIN#F-box and WD-40 domain protein 7#P01239#Cullin#;hSel10#PROTEIN#F-box and WD-40 domain protein 7#P01240## inside PROTEIN p33 PROTEIN p13 PROTEIN p32 Long Name: Cyclin E Synonym: Synonym not specified Accession: P01213 inside PROTEIN p31 Long Name: a119_degraded Synonym: Synonym not specified Accession: U02573 inside DEGRADED a119_degraded Long Name: Complex I Synonym: Synonym not specified Accession: P01237 inside PROTEIN p3 Long Name: alpha-Synuclein Synonym: Synonym not specified Accession: P01218 outerSurface PROTEIN p1 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05498 Heterodimer Member Info: alpha-Synuclein#PROTEIN#alpha-Synuclein#P01218##;N Y125#ION#N Y125#U02578## inside ION N_br_Y125 PROTEIN p1 Long Name: Calcium/calmodulin-dependent serine protein kinase Synonym: Synonym not specified Accession: P01232 inside PROTEIN p34 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05499 Heterodimer Member Info: Parkin#PROTEIN#Parkin#P01216##;CASK#PROTEIN#Calcium/calmodulin-dependent serine protein kinase#P01232## inside PROTEIN p34 PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05491 Heterodimer Member Info: O-glyc#ION#O-glyc#U02571##;alpha-Synuclein#PROTEIN#alpha-Synuclein#P01218## inside ION O-glyc PROTEIN p1 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05486 Heterodimer Member Info: O-glyc#ION#O-glyc#U02571##;Parkin#PROTEIN#Parkin#P01216##;alpha-Synuclein#PROTEIN#alpha-Synuclein#P01218## inside ION O-glyc PROTEIN p1 PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05500 Heterodimer Member Info: O-glyc#ION#O-glyc#U02571##;Parkin#PROTEIN#Parkin#P01216##;alpha-Synuclein#PROTEIN#alpha-Synuclein#P01218## inside ION O-glyc PROTEIN p1 PROTEIN p13 Long Name: a148_degraded Synonym: Synonym not specified Accession: U02574 inside DEGRADED a148_degraded Long Name: Tyrosine hydroxylase Synonym: Synonym not specified Accession: P01241 inside PROTEIN p35 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05492 Heterodimer Member Info: Parkin#PROTEIN#Parkin#P01216##;TH#PROTEIN#Tyrosine hydroxylase#P01241## inside PROTEIN p35 PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05497 Heterodimer Member Info: Parkin#PROTEIN#Parkin#P01216##;TH#PROTEIN#Tyrosine hydroxylase#P01241## inside PROTEIN p35 PROTEIN p13 Long Name: L-tyrosine Synonym: Synonym not specified Accession: S01820 inside SIMPLE_MOLECULE L-tyrosine Long Name: 3,4-Dihydroxy-L-phenylalanine Synonym: Synonym not specified Accession: S01817 inside SIMPLE_MOLECULE L-DOPA Long Name: a157_degraded Synonym: Synonym not specified Accession: U02577 inside DEGRADED a157_degraded Long Name: Cell division cycle-related protein 1 Synonym: Synonym not specified Accession: P01226 inside PROTEIN p36 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05489 Heterodimer Member Info: Parkin#PROTEIN#Parkin#P01216##;CDCrel-1#PROTEIN#Cell division cycle-related protein 1#P01226## inside PROTEIN p36 PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05487 Heterodimer Member Info: Parkin#PROTEIN#Parkin#P01216##;CDCrel-1#PROTEIN#Cell division cycle-related protein 1#P01226## inside PROTEIN p36 PROTEIN p13 Long Name: a173_degraded Synonym: Synonym not specified Accession: U02579 inside DEGRADED a173_degraded Long Name: Syntaxin Synonym: Synonym not specified Accession: P01215 transmembrane PROTEIN p37 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05488 Heterodimer Member Info: Syntaxin#PROTEIN#Syntaxin#P01215##;CDCrel-1#PROTEIN#Cell division cycle-related protein 1#P01226## transmembrane PROTEIN p36 PROTEIN p37 Long Name: Carboxyl terminus of the Hsc-70 interacting protein Synonym: Synonym not specified Accession: P01214 inside PROTEIN p38 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05481 Heterodimer Member Info: O C342#ION#O C342#U02575##;DAT#PROTEIN#Dopamine transporter#P01228## transmembrane PROTEIN p2 ION O C342 Long Name: Dopamine transporter Synonym: Synonym not specified Accession: G01547 inside GENE DAT STATE_TRANSITION s1 s2 0.33333333333333304,4.440892098500626E-16 0.666666666666667,8.881784197001252E-16 a1 a2 STATE_TRANSITION s6 s7 0.3333333333333335,-1.7763568394002505E-15 0.6666666666666667,0.0 a6 a7 TRANSPORT s7 s8 0.33333333333333337,0.0 0.6666666666666665,-8.881784197001252E-16 a7 a8 TRANSPORT s9 s10 0.33333333333333337,-8.881784197001252E-16 0.6666666666666664,-8.881784197001252E-16 a9 a10 STATE_TRANSITION s99 s99 0.33333333333333304,0.0 0.666666666666667,0.0 a14 a15 STATE_TRANSITION s17 s17 0.3000368515748626,-0.1287637380503357 0.7943898896620532,-0.16232034857254973 a19 a20 STATE_TRANSITION s1 s27 0.33549259158900946,0.06824896030913807 0.6563803900921652,0.10437561000787765 a1 a34 DISSOCIATION s31 s26,s24 0.33333333333333215,0.0 0.6666666666666679,0.0 0.33333333333333237,-8.881784197001252E-16 0.6666666666666659,-8.881784197001252E-16 0.33333333333333304,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 0.3333333333333339,0.33333333333333304 a39 a32 a35 HETERODIMER_ASSOCIATION s1,s24 s32 0.3333333333333337,0.0 0.6666666666666672,0.0 0.3333333333333339,-3.3306690738754696E-16 0.6666666666666696,-1.2212453270876722E-15 0.3333333333333335,4.440892098500626E-16 0.666666666666667,1.3322676295501878E-15 0.3333333333333357,0.33333333333333304 a1 a35 a42 HETERODIMER_ASSOCIATION s1,s28 s35 0.3333333333333339,0.0 0.6666666666666661,-4.440892098500626E-16 0.3333333333333335,0.0 0.6666666666666665,0.0 0.3333333333333326,4.440892098500626E-16 0.6666666666666661,0.0 -9.907121950960551E-4,0.48323536891716334 a1 a49 a50 STATE_TRANSITION s18 s39 0.3333333333333339,8.881784197001252E-16 0.666666666666667,1.7763568394002505E-15 a21 a56 STATE_TRANSITION s1 s40 0.3333333333333335,-2.7755575615628914E-16 0.6666666666666665,-3.885780586188048E-16 a1 a57 STATE_TRANSITION s40 s41 0.3333333333333337,0.0 0.6666666666666667,0.0 a57 a58 HETERODIMER_ASSOCIATION s1,s47 s48 0.3333333333333339,0.0 0.6666666666666661,0.0 0.3333333333333357,3.552713678800501E-15 0.6666666666666643,3.552713678800501E-15 0.33333333333333304,-1.1102230246251565E-16 0.666666666666667,-1.1102230246251565E-16 0.33333333333393966,0.33333333333328596 a64 a65 a68 STATE_TRANSITION s55 s53 0.33333333333333304,0.0 0.6666666666666661,0.0 a73 a77 STATE_TRANSITION s72 s56 0.3333333333333357,0.0 0.6666666666666661,0.0 a78 a79 STATE_TRANSITION s58 s14 0.3333333333333339,1.7763568394002505E-15 0.6666666666666625,0.0 a81 a16 STATE_TRANSITION s58 s16 0.3333333333333304,8.881784197001252E-16 0.6666666666666643,8.881784197001252E-16 a81 a18 HETERODIMER_ASSOCIATION s28,s64 s65 0.3333333333333339,-4.440892098500626E-16 0.6666666666666679,-4.440892098500626E-16 0.33333333333333304,0.0 0.666666666666667,-1.7763568394002505E-15 0.33333333333333304,8.881784197001252E-16 0.666666666666667,0.0 0.33333333333333215,0.33333333333333415 a49 a87 a90 STATE_TRANSITION s66 s67 0.3333333333333335,0.0 0.6666666666666665,0.0 a92 a93 STATE_TRANSITION s65 s66 0.3333333333333335,0.0 0.666666666666667,-8.881784197001252E-16 a90 a95 a92 STATE_TRANSITION s49 s18 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a69 a21 STATE_TRANSITION s49 s50 0.3333333333333339,-8.881784197001252E-16 0.6666666666666679,-8.881784197001252E-16 a69 a70 STATE_TRANSITION s71 s70 0.3333333333333339,0.0 0.6666666666666679,-3.552713678800501E-15 a96 a98 STATE_TRANSITION s74 s73 0.33333333333333215,0.0 0.6666666666666661,0.0 a99 a100 HETERODIMER_ASSOCIATION s64,s75 s77 0.3333333333333339,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 0.3333333333333357,1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 0.3333333333333339,1.7763568394002505E-15 0.666666666666667,3.552713678800501E-15 0.33333333333333304,0.3333333333333338 a103 a101 a106 STATE_TRANSITION s77 s80 0.3333333333333335,8.881784197001252E-16 0.666666666666667,2.6645352591003757E-15 a106 a163 a109 STATE_TRANSITION s80 s83 0.33333333333333304,0.0 0.666666666666667,0.0 a109 a112 STATE_TRANSITION s84 s89 0.33333333333333326,-1.7763568394002505E-15 0.6666666666666672,0.0 a113 a119 STATE_TRANSITION s89 s90 0.3333333333333339,0.0 0.666666666666667,0.0 a119 a120 STATE_TRANSITION s1 s101 0.3333333333333339,8.881784197001252E-16 0.6666666666666679,-8.881784197001252E-16 a1 a124 HETERODIMER_ASSOCIATION s102,s64 s103 0.33333333333333304,-8.881784197001252E-16 0.666666666666667,0.0 0.33333333333333326,0.0 0.6666666666666667,0.0 0.33333333333333215,6.661338147750939E-16 0.6666666666666661,2.220446049250313E-16 0.3333333333333335,0.33333333333333304 a126 a128 a129 STATE_TRANSITION s1 s105 0.33333333333333304,0.0 0.6666666666666661,0.0 a130 a133 STATE_TRANSITION s106 s108 0.33333333333333304,-8.881784197001252E-16 0.6666666666666661,0.0 a141 a164 a148 HETERODIMER_ASSOCIATION s105,s64 s106 0.3333333333333339,0.0 0.6666666666666679,-1.7763568394002505E-15 0.33333333333333304,-1.7763568394002505E-15 0.6666666666666679,-8.881784197001252E-16 0.3333333333333328,-1.7763568394002505E-15 0.6666666666666667,0.0 0.33333333333333304,0.33333333333333315 a133 a137 a141 STATE_TRANSITION s108 s109 0.3333333333333339,0.0 0.6666666666666679,0.0 a148 a149 STATE_TRANSITION s112 s113 0.33333333333333326,0.0 0.6666666666666667,-1.7763568394002505E-15 a156 a165 a157 HETERODIMER_ASSOCIATION s64,s110 s112 0.33333333333333304,0.0 0.6666666666666665,4.440892098500626E-16 0.33333333333333304,0.0 0.6666666666666665,0.0 0.33333333333333437,-2.498001805406602E-16 0.6666666666666665,-6.938893903907228E-16 0.3333333333333337,0.33333333333333304 a150 a151 a156 STATE_TRANSITION s114 s115 0.33333333333333304,4.440892098500626E-16 0.6666666666666667,1.3322676295501878E-15 a158 a159 STATE_TRANSITION s113 s116 0.33333333333333304,-8.881784197001252E-16 0.6666666666666665,-8.881784197001252E-16 a157 a162 HETERODIMER_ASSOCIATION s117,s64 s120 0.33333333333333304,0.0 0.666666666666667,-4.440892098500626E-16 0.33333333333333215,0.0 0.666666666666667,0.0 0.33333333333333304,0.0 0.6666666666666665,-4.440892098500626E-16 0.3333333333333339,0.33333333333333326 a168 a128 a174 STATE_TRANSITION s120 s119 0.33333333333333326,-4.440892098500626E-16 0.666666666666667,-8.881784197001252E-16 a174 a173 STATE_TRANSITION s119 s121 0.33333333333333304,-4.440892098500626E-16 0.6666666666666663,-4.440892098500626E-16 a173 a175 HETERODIMER_ASSOCIATION s117,s123 s124 0.33333333333333215,0.0 0.6666666666666661,0.0 0.3333333333333339,8.881784197001252E-16 0.666666666666667,8.881784197001252E-16 0.3333333333333337,3.552713678800501E-15 0.666666666666667,4.440892098500626E-15 0.3333333333333339,0.3333333333333335 a168 a177 a180 STATE_TRANSITION s5 s126 0.3333333333333339,-1.1102230246251565E-16 0.6666666666666661,-3.3306690738754696E-16 a5 a183 TRANSCRIPTIONAL_ACTIVATION s1 s127 0.3333333333333335,0.0 0.666666666666667,0.0 a1 a184 UNKNOWN_TRANSITION s127 s5 0.3333333333333339,-4.440892098500626E-16 0.6666666666666679,4.440892098500626E-16 a184 a5