2.3 SQUARE_CLOSEUP_NORTHEAST SQUARE_CLOSEUP_NORTHEAST inactive active inactive inactive inactive inactive inactive inactive active active active inactive active inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive active active active active inactive active inactive active inactive inactive inactive inactive active active inactive inactive active active active active inactive inactive inactive active active active active inactive active inactive active inactive active inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active inactive active inactive active inactive inactive inactive inactive inactive Plasma Membrane Nucleus Long Name: Phosphoinositide-3 kinase Synonym: PI3 kinase,PI3K Accession: P04567 inside PROTEIN p10 Long Name: Ral guanine nucleotide dissociation stimulator Synonym: RalGDS Accession: P04551 inside PROTEIN p13 Long Name: T-cell lymphoma invasion and metastasis Synonym: T-cell lymphoma invasion and metastasis Accession: P04571 inside PROTEIN p14 Long Name: Son of sevenless Synonym: SOS Accession: P04552 inside PROTEIN p17 Long Name: Growth factor receptor-bound protein-2 Synonym: Synonym not specified Accession: P04544 inside PROTEIN p16 Long Name: Mitogen activated protein kinase kinase kinase Synonym: MAPKKK,MEK kinase,MEKK1,MEKK4 Accession: P04543 inside PROTEIN p12 Long Name: GTP Synonym: Synonym not specified Accession: S04844 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S04845 inside SIMPLE_MOLECULE GDP Long Name: Rac Synonym: Synonym not specified Accession: P04559 inside PROTEIN p19 Long Name: Rho Synonym: Synonym not specified Accession: P04578 inside PROTEIN p20 Long Name: Cdc42 Synonym: Synonym not specified Accession: P04569 inside PROTEIN p21 Long Name: P21 activated kinase Synonym: PAK Accession: P04553 inside PROTEIN p22 Long Name: Mitogen activated protein kinase kinase 4/7 Synonym: JNK kinase,JNKK,MKK4,MKK7,SEK1 Accession: P04565 inside PROTEIN p23 Long Name: Mitogen activated protein kinase kinase 4/7 Synonym: JNK kinase,JNKK,MKK4,MKK7,SEK1 Accession: P04565 inside PROTEIN p23 Long Name: Jun kinase n-terminal kinase Synonym: JNK,SAPK,stress activated protein kinase Accession: P04572 inside PROTEIN p24 Long Name: Jun kinase n-terminal kinase Synonym: JNK,SAPK,stress activated protein kinase Accession: P04572 inside PROTEIN p24 Long Name: Mixed lineage kinase Synonym: MLK3 Accession: P04562 inside PROTEIN p25 Long Name: TAK Synonym: Synonym not specified Accession: P04575 inside PROTEIN p26 Long Name: Mitogen activated protein kinase kinase Synonym: MAP kinase kinase,MAPKK,MEK Accession: P04557 inside PROTEIN p27 Long Name: Extracellular signal-regulated kinase Synonym: ERK,MAP kinase,MAPK,Mitogen activated protein kinase Accession: P04542 inside PROTEIN p28 Long Name: Mitogen activated protein kinase kinase Synonym: MAP kinase kinase,MAPKK,MEK Accession: P04557 inside PROTEIN p27 Long Name: Extracellular signal-regulated kinase Synonym: ERK,MAP kinase,MAPK,Mitogen activated protein kinase Accession: P04542 inside PROTEIN p28 Long Name: p90 ribosomal S6 kinase Synonym: MAPK-activated protein kinase-1,MAPKAP-KI,p90RSK Accession: P04541 inside PROTEIN p30 Long Name: p90 ribosomal S6 kinase Synonym: MAPK-activated protein kinase-1,MAPKAP-KI,p90RSK Accession: P04541 inside PROTEIN p30 Long Name: Phospholipase D Synonym: PLD Accession: P04574 inside PROTEIN p31 Long Name: Sec5 Synonym: Synonym not specified Accession: P04545 inside PROTEIN p32 Long Name: Ral binding protein 1 Synonym: RLIP76,RalBP1 Accession: P04554 inside PROTEIN p33 Long Name: Raf Synonym: A-Raf,B-Raf,C-RAF,MAPKKK,MEKK,Mitogen activated protein kinase kinase kinase Accession: P04556 inside PROTEIN p11 Long Name: Phosphoinositide dependent kinase Synonym: PDK Accession: P04555 inside PROTEIN p34 Long Name: Mitogen activated protein kinase kinase 3/6 Synonym: MAPKK3/6,MKK3/6 Accession: P04568 inside PROTEIN p37 Long Name: Mitogen activated protein kinase kinase 3/6 Synonym: MAPKK3/6,MKK3/6 Accession: P04568 inside PROTEIN p37 Long Name: p38 mitogen activated protein kinase Synonym: p38,p38MAPK Accession: P04558 inside PROTEIN p38 Long Name: Vesicle Trafficking Synonym: Synonym not specified Accession: U05512 inside PHENOTYPE Vesicle Trafficking Long Name: Survival Synonym: Synonym not specified Accession: U05516 inside PHENOTYPE Survival Long Name: Apoptosis Synonym: Synonym not specified Accession: U05511 inside PHENOTYPE Apoptosis Long Name: Proliferation Synonym: Synonym not specified Accession: U05513 inside PHENOTYPE Proliferation Long Name: Cytoskeletal Reorganization Synonym: Synonym not specified Accession: U05515 inside PHENOTYPE Cytoskeletal Reorganization Long Name: Ets Synonym: Synonym not specified Accession: P04563 inside PROTEIN p39 Long Name: Ets Synonym: Synonym not specified Accession: P04563 inside PROTEIN p39 Long Name: Elk-1 Synonym: Synonym not specified Accession: P04573 inside PROTEIN p45 Long Name: Elk-1 Synonym: Synonym not specified Accession: P04573 inside PROTEIN p45 Long Name: Serum response factor Synonym: SRF Accession: P04561 inside PROTEIN p42 Long Name: Mitogen activated protein kinase activated protein kinase Synonym: MK Accession: P04564 inside PROTEIN p29 Long Name: Mitogen activated protein kinase activated protein kinase Synonym: MK Accession: P04564 inside PROTEIN p29 Long Name: AP1 Synonym: Synonym not specified Accession: P04560 inside PROTEIN p41 Long Name: AP1 Synonym: Synonym not specified Accession: P04560 inside PROTEIN p41 Long Name: Signal transducer and activator of transcription Synonym: STAT Accession: P04566 inside PROTEIN p43 Long Name: Signal transducer and activator of transcription Synonym: STAT Accession: P04566 inside PROTEIN p43 Long Name: Activating transcription factor 2 Synonym: Synonym not specified Accession: P04548 inside PROTEIN p40 Long Name: Activating transcription factor 2 Synonym: Synonym not specified Accession: P04548 inside PROTEIN p40 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05510 Heterodimer Member Info: Grb2#PROTEIN#Growth factor receptor-bound protein-2#P04544##;SOS#PROTEIN#Son of sevenless#P04552#SOS#;Shc#PROTEIN#Shc#P04579## inside PROTEIN p15 PROTEIN p16 PROTEIN p17 Long Name: Shc Synonym: Synonym not specified Accession: P04579 inside PROTEIN p15 Long Name: Ras Synonym: Synonym not specified Accession: P04547 inside PROTEIN p4 Long Name: Growth factor receptor Synonym: Synonym not specified Accession: P04549 transmembrane PROTEIN p5 Long Name: Growth factor Synonym: Synonym not specified Accession: P04577 inside PROTEIN p6 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05509 Heterodimer Member Info: Growth factor receptor#PROTEIN#Growth factor receptor#P04549##;Growth factor#PROTEIN#Growth factor#P04577## transmembrane PROTEIN p5 2 PROTEIN p6 Long Name: Ral Synonym: Synonym not specified Accession: P04550 inside PROTEIN p18 Long Name: Glycogen synthase kinase 3 Synonym: GSK3 Accession: P04546 inside PROTEIN p36 Long Name: Glycogen synthase kinase 3 Synonym: GSK3 Accession: P04546 inside PROTEIN p36 Long Name: AKT Synonym: PKB,Protein Kinase B Accession: P04570 inside PROTEIN p35 Long Name: AKT Synonym: PKB,Protein Kinase B Accession: P04570 inside PROTEIN p35 Long Name: p38 mitogen activated protein kinase Synonym: p38,p38MAPK Accession: P04558 inside PROTEIN p38 Long Name: Pip2 Synonym: Synonym not specified Accession: S04843 inside SIMPLE_MOLECULE Pip2 Long Name: Pip3 Synonym: Synonym not specified Accession: S04842 inside SIMPLE_MOLECULE Pip3 Long Name: Serum response factor Synonym: SRF Accession: P04561 inside PROTEIN p42 Long Name: p14/19 ARF Synonym: Synonym not specified Accession: P04576 Pathway Link: P04398|P04655|p53 pathway feedback loops 2*P00059|P01482|p53 pathway inside PROTEIN p46 Long Name: p53 pathway Synonym: Synonym not specified Accession: U05514 inside PHENOTYPE p53 pathway STATE_TRANSITION s98 s98 0.3333333333333335,-1.3322676295501878E-15 0.6666666666666665,-3.1086244689504383E-15 a4 a52 a5 a53 a42 STATE_TRANSITION s15 s15 0.3333333333333339,0.0 0.6666666666666674,0.0 a16 a30 a5 STATE_TRANSITION s17 s17 0.33333333333333304,0.0 0.6666666666666661,0.0 a18 a31 a5 STATE_TRANSITION s18 s18 0.33333333333333304,1.7763568394002505E-15 0.666666666666667,2.6645352591003757E-15 a19 a32 a5 HETERODIMER_ASSOCIATION s23,s24 s27 0.3333333333333339,-4.440892098500626E-16 0.6666666666666665,0.0 0.33333333333333326,0.0 0.6666666666666667,0.0 0.3333333333333335,0.0 0.6666666666666667,0.0 0.33333333333333304,0.3333333333333333 a35 a36 a34 a42 a120 STATE_TRANSITION s16 s16 0.3333333333333335,-1.7763568394002505E-15 0.6666666666666665,-2.6645352591003757E-15 a17 a46 a58 a5 STATE_TRANSITION s102 s102 0.3333333333333339,7.105427357601002E-15 0.6666666666666679,1.2434497875801753E-14 a47 a49 a48 a50 a31 STATE_TRANSITION s36 s36 0.33333333333333215,0.0 0.6666666666666661,0.0 a54 a58 a32 a60 a59 STATE_TRANSITION s37 s37 0.3333333333333339,0.0 0.6666666666666679,0.0 a55 a59 a58 STATE_TRANSITION s38 s38 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666661,-5.329070518200751E-15 a56 a60 a58 STATE_TRANSITION s39 s39 0.3333333333333339,0.0 0.6666666666666661,-1.7763568394002505E-15 a57 a62 a58 STATE_TRANSITION s40 s41 0.3333333333333335,-2.6645352591003757E-15 0.6666666666666665,-3.552713678800501E-15 a63 a64 a46 STATE_TRANSITION s42 s43 0.3333333333333335,3.552713678800501E-15 0.6666666666666661,7.993605777301127E-15 a65 a68 a62 a64 STATE_TRANSITION s50 s52 0.33333333333333326,-3.552713678800501E-15 0.6666666666666665,-6.217248937900877E-15 a71 a74 a30 STATE_TRANSITION s51 s53 0.33333333333333326,-2.6645352591003757E-15 0.6666666666666665,-6.217248937900877E-15 a72 a76 a74 STATE_TRANSITION s45 s45 0.33333333333333304,8.881784197001252E-16 0.6666666666666661,8.881784197001252E-16 a70 a79 a5 STATE_TRANSITION s44 s44 0.33333333333333304,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a69 a80 a5 STATE_TRANSITION s55 s56 0.33333333333333304,-8.881784197001252E-16 0.6666666666666665,-8.881784197001252E-16 a78 a81 a76 STATE_TRANSITION s59 s59 0.3333333333333357,-1.7763568394002505E-15 0.6666666666666679,-3.552713678800501E-15 a85 a88 a48 STATE_TRANSITION s58 s58 0.3333333333333339,-3.552713678800501E-15 0.6666666666666661,-8.881784197001252E-15 a84 a87 a48 STATE_TRANSITION s57 s57 0.3333333333333357,1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 a83 a86 a48 STATE_TRANSITION s54 s60 0.3333333333333333,0.0 0.6666666666666667,0.0 a77 a82 a76 STATE_TRANSITION s14 s14 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a15 a89 STATE_TRANSITION s14 s14 0.3333333333333335,-8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a15 a89 a5 STATE_TRANSITION s63 s63 0.33333333333333304,0.0 0.666666666666667,0.0 a90 a91 a122 STATE_TRANSITION s64 s104 0.3333333333333335,0.0 0.666666666666667,0.0 a92 a93 a91 STATE_TRANSITION s65 s103 0.3333333333333328,-8.881784197001252E-16 0.6666666666666663,0.0 a94 a95 a93 STATE_TRANSITION s66 s67 0.33333333333333304,0.0 0.6666666666666661,0.0 a96 a97 a46 a80 a79 STATE_TRANSITION s68 s105 0.33333333333333304,0.0 0.6666666666666652,0.0 a98 a99 a97 STATE_TRANSITION s74 s86 0.33333333333333337,0.0 0.6666666666666669,3.552713678800501E-15 a105 a111 a76 INHIBITION s104 s72 0.33333333333333337,-1.1102230246251565E-16 0.6666666666666669,-3.3306690738754696E-16 a93 a103 STATE_TRANSITION s87 s89 0.3333333333333335,-1.7763568394002505E-15 0.6666666666666665,-1.7763568394002505E-15 a117 a118 a68 a99 a76 INHIBITION s103 s71 0.049998102722747295,0.07168143970962615 0.6717601466800571,-0.22384961902087336 a95 a102 INHIBITION s103 s73 0.020883341865594984,0.06697381475238356 0.8787427620456982,-0.17196845296279722 a95 a104 STATE_TRANSITION s77 s108 0.3333333333333339,1.7763568394002505E-15 0.6666666666666661,1.7763568394002505E-15 a108 a115 a82 a81 STATE_TRANSITION s76 s90 0.33333333333333304,1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 a107 a114 a68 a81 a76 STATE_TRANSITION s78 s91 0.3333333333333339,5.329070518200751E-15 0.666666666666667,8.881784197001252E-15 a109 a113 a99 a76 a68 STATE_TRANSITION s75 s92 0.33333333333333304,0.0 0.6666666666666661,1.7763568394002505E-15 a106 a112 a99 a68 TRANSCRIPTIONAL_ACTIVATION s90 s71 0.3333333333333339,4.440892098500626E-16 0.666666666666667,0.0 a114 a102 TRANSCRIPTIONAL_ACTIVATION s90 s73 0.33333333333333326,0.0 0.6666666666666667,-2.220446049250313E-16 a114 a104 TRANSCRIPTIONAL_ACTIVATION s108 s73 0.8504798578714976,-0.0528429758038369 0.9116084542441034,-0.041371185145521405 a115 a104 TRANSCRIPTIONAL_ACTIVATION s108 s71 0.3333333333333335,4.440892098500626E-16 0.6666666666666674,-4.440892098500626E-16 a115 a102 TRANSCRIPTIONAL_ACTIVATION s89 s71 0.33333333333333326,2.220446049250313E-16 0.6666666666666661,2.220446049250313E-16 a118 a102 TRANSCRIPTIONAL_ACTIVATION s89 s73 0.6665486314012317,-0.10706998260316347 0.8890299898844014,-0.1425672470073378 a118 a104 HETERODIMER_ASSOCIATION s10,s6 s100 0.3333333333333337,0.0 0.6666666666666672,-5.551115123125783E-17 0.3333333333333337,2.220446049250313E-16 0.6666666666666667,0.0 0.3333333333333337,1.1102230246251565E-16 0.666666666666667,3.885780586188048E-16 0.33333333333333315,0.33333333333333337 a10 a6 a120 STATE_TRANSITION s106 s107 0.33333333333333304,8.881784197001252E-16 0.6666666666666663,8.881784197001252E-16 a121 a122 a89 KNOWN_TRANSITION_OMITTED s38 s73 0.2041458326434613,-0.3235096084859339 0.7399913904433921,-0.12455158559334412 a60 a104 KNOWN_TRANSITION_OMITTED s37 s73 0.12130794962847391,-0.2737545816794771 0.718714791705263,-0.1027292643268003 a59 a104 KNOWN_TRANSITION_OMITTED s38 s70 0.4747318239142513,-0.400896621726328 0.8310288613127823,-0.18241042476005875 a60 a101 KNOWN_TRANSITION_OMITTED s37 s70 0.35762876345038386,-0.4216088255790619 0.7653785478898687,-0.18982800042521608 a59 a101 KNOWN_TRANSITION_OMITTED s36 s73 0.09635902484048109,-0.26789708378457 0.6965455902542452,-0.10462083591378235 a58 a104 KNOWN_TRANSITION_OMITTED s36 s70 0.1873407257913704,-0.2827954711627352 0.34243300962409506,-0.47750434185725776 a58 a101 KNOWN_TRANSITION_OMITTED s58 s69 0.3642052010614598,-0.12827370961216644 0.6497441932239683,-0.07401396813313932 a87 a100 KNOWN_TRANSITION_OMITTED s59 s69 0.3160997692078411,-0.05139055171558127 0.6686801389100374,-0.027337556129066964 a88 a100 KNOWN_TRANSITION_OMITTED s57 s73 0.35357422762303736,-0.11267039757208774 0.6763858306073425,-0.05885244893109709 a86 a104 UNKNOWN_TRANSITION s98 s109 0.33333333333333337,-1.1102230246251565E-16 0.6666666666666667,-1.1102230246251565E-16 a5 a123 KNOWN_TRANSITION_OMITTED s109 s110 0.33333333333333326,-1.1102230246251565E-16 0.6666666666666665,-2.498001805406602E-16 a123 a124