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The data herein were made in part with support under Grant Number
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<![CDATA[
Synaptic vesicle trafficking at the presynaptic active zone is a key process regulating synatpci transmission.  The increase of Ca++ concentration triggers the docking of synatptic vesicle to the presynatpci membrane.  Vesicle proteins, such as synaptotagmin and synaptobrevin, interact with syntaxin and SNAP25 on the presynaptic membrane to for the SNARE complex.  The vesicle membrane then fuses with the presynptic membrane, which results in neurotransmitter release to the synatpci cleft.  Subsequently, the SNARE complex is disassembled, and the vesicle is recycled.
Medline=16707259
Medline=12154365
Medline=12600315
Medline=15217342
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<celldesigner:bounds h="40.0" w="80.0" x="1609.0" y="383.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="626.0" y="-455.0"/>
<celldesigner:boxSize height="40.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="sa82" species="s92">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="87.0" w="244.0" x="574.0" y="197.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-409.0" y="-641.0"/>
<celldesigner:boxSize height="87.0" width="244.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="csa3" id="sa84" species="s100">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="29.0" w="64.0" x="1883.0" y="821.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="359.0" y="109.0"/>
<celldesigner:boxSize height="29.0" width="64.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffab3ef7" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias complexSpeciesAlias="csa3" id="sa85" species="s100">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="29.0" w="64.0" x="1550.0" y="825.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="26.0" y="113.0"/>
<celldesigner:boxSize height="29.0" width="64.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffab3ef7" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="sa86" species="s101">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="30.0" w="80.0" x="533.0" y="783.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="-450.0" y="-55.0"/>
<celldesigner:boxSize height="30.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="sa87" species="s102">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="30.0" w="80.0" x="1210.0" y="765.0"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="227.0" y="-73.0"/>
<celldesigner:boxSize height="30.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="sa88" species="s93">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="29.0" w="64.0" x="1336.0" y="660.5"/>
<celldesigner:view state="usual"/>
<celldesigner:usualView>
<celldesigner:innerPosition x="353.0" y="-177.5"/>
<celldesigner:boxSize height="29.0" width="64.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffab3ef7" scheme="Color"/>
</celldesigner:usualView>
<celldesigner:briefView>
<celldesigner:innerPosition x="0.0" y="0.0"/>
<celldesigner:boxSize height="60.0" width="80.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="3fff0000" scheme="Color"/>
</celldesigner:briefView>
</celldesigner:speciesAlias>
</celldesigner:listOfSpeciesAliases>
<celldesigner:listOfGroups/>
<celldesigner:listOfProteins>
<celldesigner:protein id="pr1" name="SNAP-25" type="GENERIC"/>
<celldesigner:protein id="pr2" name="Syntaxin 1/2" type="GENERIC"/>
<celldesigner:protein id="pr3" name="Synaptotagmin" type="GENERIC"/>
<celldesigner:protein id="pr4" name="Synaptobrevin" type="GENERIC"/>
<celldesigner:protein id="pr5" name="Synaptophysin" type="GENERIC"/>
<celldesigner:protein id="pr8" name="Rab3A" type="GENERIC"/>
<celldesigner:protein id="pr9" name="Synapsin" type="GENERIC"/>
<celldesigner:protein id="pr10" name="NSF" type="GENERIC"/>
<celldesigner:protein id="pr11" name="SNAP" type="GENERIC"/>
<celldesigner:protein id="pr12" name="Munc13" type="GENERIC"/>
<celldesigner:protein id="pr6" name="Munc18" type="GENERIC"/>
<celldesigner:protein id="pr7" name="RIM1_alpha__slash_2_alpha_" type="GENERIC"/>
</celldesigner:listOfProteins>
<celldesigner:listOfGenes/>
<celldesigner:listOfRNAs/>
<celldesigner:listOfAntisenseRNAs/>
<celldesigner:listOfBlockDiagrams/>
</annotation>
<listOfCompartments>
<compartment id="default"/>
<compartment id="c1" name="Presynaptic" outside="default">
<annotation>
<celldesigner:name >Presynaptic</celldesigner:name>
</annotation>
</compartment>
<compartment id="c2" name="Synaptic vesicle" outside="c1">
<annotation>
<celldesigner:name >Synaptic vesicle</celldesigner:name>
</annotation>
</compartment>
<compartment id="c3" name="synaptic vesicle" outside="c1">
<annotation>
<celldesigner:name >synaptic vesicle</celldesigner:name>
</annotation>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species compartment="c1" id="s2" initialAmount="0.0" name="Syntaxin 1/2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Syntaxin 1/2
Synonym:  Stx1/2
Accession:  P05772
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s3" initialAmount="0.0" name="Synaptotagmin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synaptotagmin
Synonym:  p65
Accession:  P05769
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s4" initialAmount="0.0" name="Synaptobrevin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synaptobrevin
Synonym:  Vesicle-associated membrane protein,VAMP
Accession:  P05779
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s11" initialAmount="0.0" name="Synaptophysin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synaptophysin
Synonym:  Synonym not specified
Accession:  P05777
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s20" initialAmount="0.0" name="SNARE complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  SNARE complex
Synonym:  Synonym not specified
Accession:  U05903
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>SNARE complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s25" initialAmount="0.0" name="SNAP-25">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synaptosomal-associated protein, 25KD
Synonym:  Synonym not specified
Accession:  P05778
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s26" initialAmount="0.0" name="SNAP-25">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synaptosomal-associated protein, 25KD
Synonym:  Synonym not specified
Accession:  P05778
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >innerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s44" initialAmount="0.0" name="SNARE complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  SNARE complex
Synonym:  Synonym not specified
Accession:  U05904
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>SNARE complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s51" initialAmount="0.0" name="synaptic vesicle fusion complex">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  synaptic vesicle fusion complex
Synonym:  Synonym not specified
Accession:  U05905
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>synaptic vesicle fusion complex</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s57" initialAmount="0.0" name="neurotransmitter">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  neurotransmitter
Synonym:  Synonym not specified
Accession:  S05860
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>neurotransmitter</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s60" initialAmount="0.0" name="neurotransmitter">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  neurotransmitter
Synonym:  Synonym not specified
Accession:  S05860
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>neurotransmitter</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s61" initialAmount="0.0" name="Rab3A">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Rab3A
Synonym:  Synonym not specified
Accession:  P05780
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s68" initialAmount="0.0" name="Rab3A">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Rab3A
Synonym:  Synonym not specified
Accession:  P05780
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >outerSurface</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s69" initialAmount="0.0" name="Ca_super_2_plus_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Ca2+
Synonym:  Synonym not specified
Accession:  U05907
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>Ca_super_2_plus_</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" id="s72" initialAmount="0.0" name="Synapsin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synapsin
Synonym:  Syn1,Brain protein 4.1
Accession:  P05775
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s75" initialAmount="0.0" name="Synapsin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synapsin
Synonym:  Syn1,Brain protein 4.1
Accession:  P05775
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s79" initialAmount="0.0" name="Synaptophysin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synaptophysin
Synonym:  Synonym not specified
Accession:  P05777
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s83" initialAmount="0.0" name="Synaptotagmin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synaptotagmin
Synonym:  p65
Accession:  P05769
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c3" id="s84" initialAmount="0.0" name="Synaptobrevin">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Synaptobrevin
Synonym:  Vesicle-associated membrane protein,VAMP
Accession:  P05779
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s87" initialAmount="0.0" name="SNARE complex dissembly">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  SNARE complex dissembly
Synonym:  Synonym not specified
Accession:  U05906
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>SNARE complex dissembly</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s90" initialAmount="0.0" name="NSF">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  N-ethylmaleimide-sensitive factor
Synonym:  Synonym not specified
Accession:  P05774
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions >
<celldesigner:catalyzed reaction="re5"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s91" initialAmount="0.0" name="SNAP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  SNAP
Synonym:  Synonym not specified
Accession:  P05771
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions >
<celldesigner:catalyzed reaction="re5"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" id="s92" initialAmount="0.0" name="Transmitter update_br_and_br_vesicle docking">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Transmitter update and vesicle docking
Synonym:  Synonym not specified
Accession:  U05908
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Transmitter update_br_and_br_vesicle docking</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s93" initialAmount="0.0" name="Munc13">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Munc13
Synonym:  UNC13
Accession:  P05773
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr12</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s95" initialAmount="0.0" name="Munc18">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Munc18
Synonym:  STXBP1,Syntaxin-binding protein 1
Accession:  P05770
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s97" initialAmount="0.0" name="RIM1_alpha__slash_2_alpha_">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Rab3A-interacting protein 1alpha/2alpha
Synonym:  Synonym not specified
Accession:  P05776
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s101" initialAmount="0.0" name="Priming">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Priming
Synonym:  Synonym not specified
Accession:  U05909
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Priming</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" id="s102" initialAmount="0.0" name="Fusion">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Fusion
Synonym:  Synonym not specified
Accession:  U05910
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment >inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity >
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Fusion</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
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<annotation>
<celldesigner:reactionType >TRANSPORT</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts >
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</celldesigner:baseProducts>
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</annotation>
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<annotation>
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</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<annotation>
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</annotation>
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<annotation>
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</speciesReference>
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<annotation>
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</speciesReference>
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<annotation>
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</speciesReference>
<speciesReference species="s95">
<annotation>
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</speciesReference>
<speciesReference species="s69">
<annotation>
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</speciesReference>
<speciesReference species="s93">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s51">
<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re4" reversible="false">
<annotation>
<celldesigner:reactionType >HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts >
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</annotation>
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<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s4">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s2">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s3">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s20">
<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction id="re5" reversible="false">
<annotation>
<celldesigner:reactionType >DISSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants >
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
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<celldesigner:line color="ff000000" width="1.0"/>
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</celldesigner:productLink>
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<celldesigner:editPoints num0="1" num1="0" num2="0" >0.4267560934004211,-0.00973535248766888 -0.36017254154759115,1.2086747115486496</celldesigner:editPoints>
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<celldesigner:listOfModification >
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<celldesigner:line color="ff000000" width="1.0"/>
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</annotation>
<listOfReactants>
<speciesReference species="s51">
<annotation>
<celldesigner:alias >csa3</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
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</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s68">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s25">
<annotation>
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</annotation>
</speciesReference>
<speciesReference species="s2">
<annotation>
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</speciesReference>
<speciesReference species="s93">
<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
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<annotation>
<celldesigner:alias >sa80</celldesigner:alias>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
</listOfReactions>
</model>
</sbml>


