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<![CDATA[
Kreb's Cycle:  Also known as Tricarboxylic Acid Cycle.
Eight enzymes of the catalytic series of well-know organic reactions that collectively oxidize an acetyl group to two CO2 molceules with the concomitant generation of three NADHs, one FADH2, and one GTP.
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<species compartment="default" initialAmount="0.0" name="s13">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Isocitrate Dehydrogenase
Synonym:  Synonym not specified
Accession:  P01265
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r6"/>
<celldesigner:catalyzed reaction="r15"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s14">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  NAD+
Synonym:  Synonym not specified
Accession:  S04851
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NAD_super_+_endsuper</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s15">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  NADH+H+
Synonym:  Synonym not specified
Accession:  S04847
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NADH+H_super_+_endsuper</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s16">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  alphaKetoglutarate
Synonym:  Synonym not specified
Accession:  S01832
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>_alpha_Ketoglutarate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s17">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  CO2
Synonym:  Synonym not specified
Accession:  S04848
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>CO_sub_2_endsub</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s18">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Succinyl-CoA
Synonym:  Synonym not specified
Accession:  S01836
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Succinyl-CoA</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s19">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  alphaketoglutarate Dehydrogenase
Synonym:  Synonym not specified
Accession:  P01269
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r16"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s20">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Succinate
Synonym:  Synonym not specified
Accession:  S01839
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Succinate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s21">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Fumarate
Synonym:  Synonym not specified
Accession:  S01845
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Fumarate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s22">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Malate
Synonym:  Synonym not specified
Accession:  S01842
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Malate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s23">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Oxaloacetate
Synonym:  Synonym not specified
Accession:  S01828
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Oxaloacetate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s24">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Succinyl CoA Synthetase
Synonym:  Synonym not specified
Accession:  P01274
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r17"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s25">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Succinate Dehydrogenase
Synonym:  Synonym not specified
Accession:  P01273
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r18"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s26">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  GDP + Pi
Synonym:  Synonym not specified
Accession:  S04849
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP + P_sub_i_endsub</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s27">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S01838
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s28">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  FAD
Synonym:  Synonym not specified
Accession:  S01844
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>FAD</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s29">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  FADH2
Synonym:  Synonym not specified
Accession:  S04846
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>FADH_sub_2_endsub</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s30">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Fumarase
Synonym:  Synonym not specified
Accession:  P01271
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r19"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s31">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Malate Dehydrogenase
Synonym:  Synonym not specified
Accession:  P01270
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r20"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s32">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Citrate Synthase
Synonym:  Synonym not specified
Accession:  P01267
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r23"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s33">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  coA + NAD+
Synonym:  Synonym not specified
Accession:  S04850
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>coA + NAD_super_+_endsuper</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s34">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CO2+ NADH
Synonym:  Synonym not specified
Accession:  S01834
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>CO_sub_2_endsub_+ NADH</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Pyruvate
Synonym:  Synonym not specified
Accession:  S01830
Pathway Link:  P00024|S01677|Glycolysis
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Pyruvate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction name="r5" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s9</celldesigner:baseReactants>
<celldesigner:baseProducts>s11</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a14" reactant="s5" targetLineIndex="-1,2"/>
</celldesigner:listOfReactantLinks>
<celldesigner:editPoints>0.33333333333333304,0.0 0.6666666666666661,-8.881784197001252E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a13" editPoints="0.33333333333333304,-8.881784197001252E-16 0.666666666666667,0.0" modifiers="s10" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s9">
<annotation>
<celldesigner:alias>a9</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s5">
<annotation>
<celldesigner:alias>a14</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s11">
<annotation>
<celldesigner:alias>a12</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r6" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s11</celldesigner:baseReactants>
<celldesigner:baseProducts>s12</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a17" reactant="s14" targetLineIndex="-1,2"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a18" product="s15" targetLineIndex="-1,2"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333328,0.0 0.6666666666666663,-1.7763568394002505E-15</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a16" editPoints="0.33333333333333304,-4.440892098500626E-16 0.6666666666666661,-8.881784197001252E-16" modifiers="s13" targetLineIndex="-1,0" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s11">
<annotation>
<celldesigner:alias>a12</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s14">
<annotation>
<celldesigner:alias>a17</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s12">
<annotation>
<celldesigner:alias>a15</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s15">
<annotation>
<celldesigner:alias>a18</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r13" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s4</celldesigner:baseReactants>
<celldesigner:baseProducts>s9</celldesigner:baseProducts>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a11" product="s5" targetLineIndex="-1,2"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333304,0.0 0.666666666666667,-2.220446049250313E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a10" editPoints="0.33333333333333326,1.7763568394002505E-15 0.6666666666666659,0.0" modifiers="s10" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s4">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s9">
<annotation>
<celldesigner:alias>a9</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s5">
<annotation>
<celldesigner:alias>a11</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r15" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s12</celldesigner:baseReactants>
<celldesigner:baseProducts>s16</celldesigner:baseProducts>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a21" product="s17" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333337,-4.440892098500626E-16 0.6666666666666667,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a20" editPoints="0.33333333333333304,-4.440892098500626E-16 0.666666666666667,-4.440892098500626E-16" modifiers="s13" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s12">
<annotation>
<celldesigner:alias>a15</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s16">
<annotation>
<celldesigner:alias>a19</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s17">
<annotation>
<celldesigner:alias>a21</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r16" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s16</celldesigner:baseReactants>
<celldesigner:baseProducts>s18</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a24" reactant="s14" targetLineIndex="-1,2"/>
<celldesigner:reactantLink alias="a26" reactant="s7" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a25" product="s15" targetLineIndex="-1,2"/>
<celldesigner:productLink alias="a27" product="s17" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333326,-2.220446049250313E-16 0.6666666666666667,-2.220446049250313E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a23" editPoints="0.3333333333333326,8.881784197001252E-16 0.6666666666666665,8.881784197001252E-16" modifiers="s19" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s16">
<annotation>
<celldesigner:alias>a19</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s14">
<annotation>
<celldesigner:alias>a24</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s7">
<annotation>
<celldesigner:alias>a26</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s18">
<annotation>
<celldesigner:alias>a22</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s15">
<annotation>
<celldesigner:alias>a25</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s17">
<annotation>
<celldesigner:alias>a27</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r17" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s18</celldesigner:baseReactants>
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