2.2 SQUARE_CLOSEUP_SOUTH OVAL SQUARE SQUARE_CLOSEUP_NORTH inactive active inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive active active active active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active Antigen-Presenting Cell Nucleus ER T cell Long Name: Lck Synonym: Lymphocyte-specific c-src family protein tyrosine kinase Accession: P01310 inside PROTEIN p12 Long Name: CD45 Synonym: Leukocyte common antigen Accession: P01329 transmembrane PROTEIN p1 Long Name: Csk Synonym: c-src kinase Accession: P01304 inside PROTEIN p2 Long Name: LAT Synonym: Linker for Activation of T cells,pp36/38 Accession: P01325 transmembrane PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05530 Heterodimer Member Info: SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# inside PROTEIN p6 PROTEIN p14 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05550 Heterodimer Member Info: Ras#PROTEIN#Ras#P01306##;GDP#SIMPLE_MOLECULE#GDP#S01855## inside PROTEIN p24 SIMPLE_MOLECULE GDP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05548 Heterodimer Member Info: Ras#PROTEIN#Ras#P01306##;GTP#SIMPLE_MOLECULE#GTP#S01856## inside PROTEIN p24 SIMPLE_MOLECULE GTP Long Name: MEK Synonym: MAPK/ERK kinase Accession: P01312 inside PROTEIN p27 Long Name: ERK Synonym: Estrogen Regulated Kinase Accession: P01300 inside PROTEIN p28 Long Name: ERK Synonym: Estrogen Regulated Kinase Accession: P01300 inside PROTEIN p28 Long Name: ERK Synonym: Estrogen Regulated Kinase Accession: P01300 inside PROTEIN p28 Long Name: Jnk Synonym: Jun kinase,c-Jun N-terminal Kinase Accession: P01336 inside PROTEIN p29 Long Name: Jnk Synonym: Jun kinase,c-Jun N-terminal Kinase Accession: P01336 inside PROTEIN p29 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05538 Heterodimer Member Info: rac#PROTEIN#rac#P01324##;GDP#SIMPLE_MOLECULE#GDP#S01855## inside PROTEIN p23 SIMPLE_MOLECULE GDP Long Name: Long Name: cdc42 Synonym: Synonym not specified Accession: U05525 Heterodimer Member Info: GDP#SIMPLE_MOLECULE#GDP#S01855##;cdc42#PROTEIN#cdc42#P01333#Cell Division Cycle 42# inside PROTEIN p22 SIMPLE_MOLECULE GDP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05542 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01856##;cdc42#PROTEIN#cdc42#P01333#Cell Division Cycle 42# inside PROTEIN p22 SIMPLE_MOLECULE GTP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05547 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01856##;cdc42#PROTEIN#cdc42#P01333#Cell Division Cycle 42#;WASP#PROTEIN#WASP#P01334#Wiscott-Aldrich Syndrome Protein# inside PROTEIN p22 SIMPLE_MOLECULE GTP PROTEIN p20 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05541 Heterodimer Member Info: Pak#PROTEIN#Pak#P01319#p21-activated kinase#;GTP#SIMPLE_MOLECULE#GTP#S01856##;rac#PROTEIN#rac#P01324## inside PROTEIN p23 SIMPLE_MOLECULE GTP PROTEIN p21 Long Name: Actin polymerization Synonym: Synonym not specified Accession: U02632 inside PHENOTYPE Actin polymerization Long Name: IP3 Synonym: Synonym not specified Accession: S01848 inside SIMPLE_MOLECULE IP3 Long Name: DAG Synonym: Synonym not specified Accession: S01850 inside SIMPLE_MOLECULE DAG Long Name: PKC theta Synonym: Protein Kinase C theta Accession: P01318 inside PROTEIN p31 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05531 Heterodimer Member Info: DAG#SIMPLE_MOLECULE#DAG#S01850##;PKC-theta#PROTEIN#PKC theta#P01318#Protein Kinase C theta# inside SIMPLE_MOLECULE DAG PROTEIN p31 Long Name: Calmodulin Synonym: Synonym not specified Accession: P01305 inside PROTEIN p36 Long Name: NF-AT Synonym: Nuclear Factor of Activated T cells Accession: P01294 inside PROTEIN p35 Long Name: NF-AT Synonym: Nuclear Factor of Activated T cells Accession: P01294 inside PROTEIN p35 Long Name: Jnk Synonym: Jun kinase,c-Jun N-terminal Kinase Accession: P01336 inside PROTEIN p29 Long Name: NF-AT Synonym: Nuclear Factor of Activated T cells Accession: P01294 inside PROTEIN p35 Long Name: jun Synonym: Synonym not specified Accession: P01335 inside PROTEIN p38 Long Name: jun Synonym: Synonym not specified Accession: P01335 inside PROTEIN p38 Long Name: ATP Synonym: Synonym not specified Accession: S01851 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01854 inside SIMPLE_MOLECULE ADP Long Name: fos Synonym: c-fos Accession: P01309 inside PROTEIN p37 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05551 Heterodimer Member Info: fos#PROTEIN#fos#P01309#c-fos#;jun#PROTEIN#jun#P01335## inside PROTEIN p38 PROTEIN p37 Long Name: TCR-responsive genes Synonym: Synonym not specified Accession: G01549 inside GENE TCR-responsive genes Long Name: T cell proliferation Synonym: Synonym not specified Accession: U02630 inside PHENOTYPE T cell proliferation Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05527 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P01303#Growth factor receptor-bound protein 2#;SOS#PROTEIN#SOS#P01307#Son of Sevenless# inside PROTEIN p18 PROTEIN p17 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05545 Heterodimer Member Info: NF-kappa B#PROTEIN#NF-kappa B#P01298#NF-kB|Nuclear factor kappa B#;I kappa B#PROTEIN#I kappa B#P01323#IkB|inhibitor of NF-kappa B# inside PROTEIN p42 PROTEIN p43 Long Name: I kappa B Synonym: IkB,inhibitor of NF-kappa B Accession: P01323 inside PROTEIN p43 Long Name: NF-kappa B Synonym: NF-kB,Nuclear factor kappa B Accession: P01298 inside PROTEIN p42 Long Name: NF-kappa B Synonym: NF-kB,Nuclear factor kappa B Accession: P01298 inside PROTEIN p42 Long Name: CD28 Synonym: Synonym not specified Accession: P01313 transmembrane PROTEIN p44 2 Long Name: PIP Synonym: Synonym not specified Accession: S01849 inside SIMPLE_MOLECULE PIP Long Name: PIP3 Synonym: Synonym not specified Accession: S01852 inside SIMPLE_MOLECULE PIP3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05532 Heterodimer Member Info: PIP2#SIMPLE_MOLECULE#PIP2#S01853##;Akt#PROTEIN#Akt#P01332#PKB|Protein Kinase B# inside SIMPLE_MOLECULE PIP2 PROTEIN p46 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05543 Heterodimer Member Info: PIP3#SIMPLE_MOLECULE#PIP3#S01852##;Akt#PROTEIN#Akt#P01332#PKB|Protein Kinase B# inside SIMPLE_MOLECULE PIP3 PROTEIN p46 Long Name: B7 Synonym: Synonym not specified Accession: P01337 transmembrane PROTEIN p47 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05553 Heterodimer Member Info: CD28#PROTEIN#CD28#P01313##;B7#PROTEIN#B7#P01337## transmembrane PROTEIN p44 2 PROTEIN p47 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05549 Heterodimer Member Info: CD28#PROTEIN#CD28#P01313##;B7#PROTEIN#B7#P01337## transmembrane PROTEIN p44 2 PROTEIN p47 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05524 Heterodimer Member Info: TCR zeta#PROTEIN#TCR zeta#P01296#CD3 zeta|T cell receptor, zeta chain#;TCR Beta#PROTEIN#TCR Beta#P01299#T cell receptor, beta chain#;TCR alpha#PROTEIN#TCR alpha#P01301#T cell receptor alpha chain#;CD3 eta#PROTEIN#CD3 epsilon#P01302##;CD3 gamma#PROTEIN#CD3 gamma#P01317##;CD3 delta#PROTEIN#CD3 delta#P01326## transmembrane PROTEIN p11 PROTEIN p3 PROTEIN p4 PROTEIN p10 PROTEIN p8 2 PROTEIN p9 2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05534 Heterodimer Member Info: TCR zeta#PROTEIN#TCR zeta#P01296#CD3 zeta|T cell receptor, zeta chain#;TCR Beta#PROTEIN#TCR Beta#P01299#T cell receptor, beta chain#;TCR alpha#PROTEIN#TCR alpha#P01301#T cell receptor alpha chain#;CD3 eta#PROTEIN#CD3 epsilon#P01302##;MHC-antigen#PROTEIN#MHC-antigen#P01316#Major Histocompatibility Complex#;CD3 gamma#PROTEIN#CD3 gamma#P01317##;CD3 delta#PROTEIN#CD3 delta#P01326## transmembrane PROTEIN p4 PROTEIN p7 PROTEIN p11 PROTEIN p3 PROTEIN p8 2 PROTEIN p10 PROTEIN p9 2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05536 Heterodimer Member Info: TCR zeta#PROTEIN#TCR zeta#P01296#CD3 zeta|T cell receptor, zeta chain#;TCR Beta#PROTEIN#TCR Beta#P01299#T cell receptor, beta chain#;TCR alpha#PROTEIN#TCR alpha#P01301#T cell receptor alpha chain#;CD3 eta#PROTEIN#CD3 epsilon#P01302##;MHC-antigen#PROTEIN#MHC-antigen#P01316#Major Histocompatibility Complex#;CD3 gamma#PROTEIN#CD3 gamma#P01317##;CD3 delta#PROTEIN#CD3 delta#P01326## transmembrane PROTEIN p4 PROTEIN p7 PROTEIN p3 PROTEIN p11 PROTEIN p10 PROTEIN p8 2 PROTEIN p9 2 Long Name: CD45 Synonym: Leukocyte common antigen Accession: P01329 transmembrane PROTEIN p1 2 Long Name: MHC-antigen Synonym: Major Histocompatibility Complex Accession: P01316 transmembrane PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05533 Heterodimer Member Info: TCR zeta#PROTEIN#TCR zeta#P01296#CD3 zeta|T cell receptor, zeta chain#;TCR Beta#PROTEIN#TCR Beta#P01299#T cell receptor, beta chain#;TCR alpha#PROTEIN#TCR alpha#P01301#T cell receptor alpha chain#;CD3 eta#PROTEIN#CD3 epsilon#P01302##;ZAP-70#PROTEIN#ZAP-70#P01308#Zeta-associated protein of 70 kD#;CD3 gamma#PROTEIN#CD3 gamma#P01317##;CD3 delta#PROTEIN#CD3 delta#P01326## transmembrane PROTEIN p4 PROTEIN p11 PROTEIN p10 PROTEIN p8 2 PROTEIN p9 2 PROTEIN p5 PROTEIN p3 Long Name: ZAP-70 Synonym: Zeta-associated protein of 70 kD Accession: P01308 inside PROTEIN p5 Long Name: LAT Synonym: Linker for Activation of T cells,pp36/38 Accession: P01325 transmembrane PROTEIN p13 Long Name: vav Synonym: Synonym not specified Accession: P01295 inside PROTEIN p15 Long Name: nck Synonym: Synonym not specified Accession: P01314 inside PROTEIN p19 Long Name: PLC-gamma Synonym: phospholipase c, gamma isoform Accession: P01320 inside PROTEIN p16 Long Name: MEK Synonym: MAPK/ERK kinase Accession: P01312 inside PROTEIN p27 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05546 Heterodimer Member Info: SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# transmembrane PROTEIN p13 PROTEIN p6 PROTEIN p14 Long Name: Akt Synonym: PKB,Protein Kinase B Accession: P01332 inside PROTEIN p46 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05528 Heterodimer Member Info: TCR zeta#PROTEIN#TCR zeta#P01296#CD3 zeta|T cell receptor, zeta chain#;TCR Beta#PROTEIN#TCR Beta#P01299#T cell receptor, beta chain#;TCR alpha#PROTEIN#TCR alpha#P01301#T cell receptor alpha chain#;CD3 eta#PROTEIN#CD3 epsilon#P01302##;ZAP-70#PROTEIN#ZAP-70#P01308#Zeta-associated protein of 70 kD#;CD3 gamma#PROTEIN#CD3 gamma#P01317##;CD3 delta#PROTEIN#CD3 delta#P01326## transmembrane PROTEIN p11 PROTEIN p4 PROTEIN p10 PROTEIN p8 2 PROTEIN p9 2 PROTEIN p5 PROTEIN p3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05535 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P01303#Growth factor receptor-bound protein 2#;SOS#PROTEIN#SOS#P01307#Son of Sevenless#;PLC-gamma#PROTEIN#PLC-gamma#P01320#phospholipase c, gamma isoform#;SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# transmembrane PROTEIN p13 PROTEIN p14 PROTEIN p17 PROTEIN p18 PROTEIN p6 PROTEIN p16 Long Name: Ca++ Synonym: Synonym not specified Accession: U02631 inside ION Ca++ Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05544 Heterodimer Member Info: Ras#PROTEIN#Ras#P01306##;Raf#PROTEIN#Raf#P01311##;MEK#PROTEIN#MEK#P01312#MAPK/ERK kinase#;GTP#SIMPLE_MOLECULE#GTP#S01856## inside PROTEIN p24 SIMPLE_MOLECULE GTP PROTEIN p25 PROTEIN p27 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05529 Heterodimer Member Info: Calmodulin#PROTEIN#Calmodulin#P01305##;Ca++#ION#Ca++#U02631## inside PROTEIN p36 ION Ca++ ION Ca++ Long Name: IP3R Synonym: IP3 Receptor Accession: P01331 transmembrane PROTEIN p40 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05539 Heterodimer Member Info: PLC-gamma#PROTEIN#PLC-gamma#P01320#phospholipase c, gamma isoform#;SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# transmembrane PROTEIN p13 PROTEIN p16 PROTEIN p6 PROTEIN p14 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05537 Heterodimer Member Info: PLC-gamma#PROTEIN#PLC-gamma#P01320#phospholipase c, gamma isoform#;SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# transmembrane PROTEIN p13 PROTEIN p16 PROTEIN p6 PROTEIN p14 Long Name: PLC-gamma Synonym: phospholipase c, gamma isoform Accession: P01320 inside PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05552 Heterodimer Member Info: vav#PROTEIN#vav#P01295##;nck#PROTEIN#nck#P01314##;Pak#PROTEIN#Pak#P01319#p21-activated kinase#;SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc#;WASP#PROTEIN#WASP#P01334#Wiscott-Aldrich Syndrome Protein# transmembrane PROTEIN p13 PROTEIN p21 PROTEIN p6 PROTEIN p14 PROTEIN p20 PROTEIN p15 PROTEIN p19 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05523 Heterodimer Member Info: vav#PROTEIN#vav#P01295##;nck#PROTEIN#nck#P01314##;SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# transmembrane PROTEIN p13 PROTEIN p6 PROTEIN p14 PROTEIN p15 PROTEIN p19 Long Name: Lck Synonym: Lymphocyte-specific c-src family protein tyrosine kinase Accession: P01310 inside PROTEIN p12 Long Name: Lck Synonym: Lymphocyte-specific c-src family protein tyrosine kinase Accession: P01310 inside PROTEIN p12 Long Name: ATP Synonym: Synonym not specified Accession: S01851 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01854 inside SIMPLE_MOLECULE ADP Long Name: Pi Synonym: Synonym not specified Accession: S01847 inside SIMPLE_MOLECULE Pi Long Name: WASP Synonym: Wiscott-Aldrich Syndrome Protein Accession: P01334 inside PROTEIN p20 Long Name: Pak Synonym: p21-activated kinase Accession: P01319 inside PROTEIN p21 Long Name: ZAP-70 Synonym: Zeta-associated protein of 70 kD Accession: P01308 inside PROTEIN p5 Long Name: Raf Synonym: Synonym not specified Accession: P01311 inside PROTEIN p25 Long Name: GTP Synonym: Synonym not specified Accession: S01856 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01855 inside SIMPLE_MOLECULE GDP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05526 Heterodimer Member Info: Ras#PROTEIN#Ras#P01306##;Raf#PROTEIN#Raf#P01311##;GTP#SIMPLE_MOLECULE#GTP#S01856## inside PROTEIN p24 SIMPLE_MOLECULE GTP PROTEIN p25 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05540 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01856##;rac#PROTEIN#rac#P01324## inside PROTEIN p23 SIMPLE_MOLECULE GTP Long Name: PIP2 Synonym: Synonym not specified Accession: S01853 inside SIMPLE_MOLECULE PIP2 Long Name: CRAC Synonym: Synonym not specified Accession: P01328 transmembrane PROTEIN p33 Long Name: Ca++ Synonym: Synonym not specified Accession: U02631 inside ION Ca++ Long Name: Calcineurin Synonym: Synonym not specified Accession: P01315 inside PROTEIN p34 Long Name: MEKK Synonym: MAP kinase kinase kinase,MEK kinase Accession: P01297 inside PROTEIN p39 Long Name: IKK Synonym: Inhibitor of NF-kappa B kinase Accession: P01330 inside PROTEIN p41 Long Name: PI3K Synonym: Phosphatidyl Inositol (3,4,5) kinase Accession: P01322 inside PROTEIN p45 Long Name: Lck Synonym: Lymphocyte-specific c-src family protein tyrosine kinase Accession: P01310 inside PROTEIN p12 Long Name: Ca++ Synonym: Synonym not specified Accession: U02631 inside ION Ca++ STATE_TRANSITION s17 s480 0.33333333333333304,0.0 0.6666666666666661,0.0 a19 a18 a34 STATE_TRANSITION s480 s479 0.3333333333333335,0.0 0.666666666666667,0.0 a18 a29 a3 a30 STATE_TRANSITION s480 s17 0.33333333333333304,0.0 0.666666666666667,0.0 a28 a31 a19 a33 STATE_TRANSITION s4 s406 0.3333333333333339,-3.219646771412954E-15 0.6666666666666661,-6.328271240363392E-15 a4 a275 STATE_TRANSITION s242 s243 0.32892023788915203,-0.009695896433655093 0.666666666666667,3.552713678800501E-15 a388 a390 a389 a391 HETERODIMER_ASSOCIATION s243,s487 s490 0.3333333333333428,0.0 0.6666666666666714,-7.105427357601002E-15 0.33333333333333215,0.0 0.6666666666666679,0.0 0.3333333333333286,0.0 0.6666666666666643,0.0 0.3333333333333337,0.3333333333333286 a389 a376 a397 STATE_TRANSITION s236 s248 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666643,-3.552713678800501E-15 a379 a403 STATE_TRANSITION s266 s491 0.33333333333333326,1.7763568394002505E-15 0.6666666666666667,-1.7763568394002505E-15 a435 a433 a434 a438 STATE_TRANSITION s267 s268 0.3333333333333335,1.7763568394002505E-15 0.6666666666666667,0.0 a436 a432 a437 a439 HETERODIMER_ASSOCIATION s491,s485 s270 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666643,0.0 0.33333333333333215,3.552713678800501E-15 0.6666666666666661,1.7763568394002505E-15 0.33333333333333304,-3.552713678800501E-15 0.6666666666666665,-3.552713678800501E-15 0.3333333333333339,0.33333333333333304 a434 a294 a454 HETERODIMER_ASSOCIATION s268,s484 s269 0.3333333333333286,-7.105427357601002E-15 0.6666666666666714,0.0 0.3333333333333338,0.0 0.6666666666666669,0.0 0.33333333333333304,0.0 0.6666666666666652,3.552713678800501E-15 0.3333333333333357,0.3333333333333357 a437 a293 a452 HETERODIMER_ASSOCIATION s282,s284 s285 0.33333333333333215,0.0 0.6666666666666661,0.0 0.3333333333333428,0.0 0.6666666666666856,0.0 0.3333333333333335,7.105427357601002E-15 0.6666666666666656,0.0 0.3333333333333286,0.3333333333333357 a471 a473 a476 STATE_TRANSITION s493 s493 0.3333333333333357,0.0 0.6666666666666643,0.0 a478 a479 STATE_TRANSITION s495 s495 0.33333333333333215,-8.881784197001252E-16 0.6666666666666643,-8.881784197001252E-16 a485 a487 STATE_TRANSITION s297 s293 0.33333333333333215,0.0 0.6666666666666679,0.0 a494 a486 a498 STATE_TRANSITION s302 s303 0.33333333333333215,0.0 0.6666666666666643,0.0 a500 a502 a501 a503 HETERODIMER_ASSOCIATION s301,s303 s306 0.3333333333333286,8.881784197001252E-16 0.6666666666666643,2.6645352591003757E-15 0.3333333333333286,0.0 0.6666666666666607,0.0 0.33333333333333215,0.0 0.6666666666666679,0.0 0.33333333333333215,0.33333333333333215 a499 a501 a506 STATE_TRANSITION s251 s253 0.3333333333333335,-3.552713678800501E-15 0.6666666666666665,-7.105427357601002E-15 a407 a406 TRANSCRIPTIONAL_ACTIVATION s306 s307 0.3333333333333351,0.0 0.6666666666666681,0.0 a506 a507 TRANSCRIPTIONAL_ACTIVATION s300 s307 0.33333333333333304,-8.881784197001252E-16 0.666666666666667,0.0 a495 a507 STATE_TRANSITION s307 s308 0.3333333333333357,-3.552713678800501E-15 0.6666666666666679,-3.552713678800501E-15 a507 a508 KNOWN_TRANSITION_OMITTED s270 s271 0.3333333333333339,1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 a454 a455 KNOWN_TRANSITION_OMITTED s269 s271 0.3333333333333335,0.0 0.6666666666666665,0.0 a452 a455 DISSOCIATION s317 s318,s264 0.33333333333333304,3.552713678800501E-15 0.666666666666667,3.552713678800501E-15 0.3333333333333286,0.0 0.6666666666666572,-1.7763568394002505E-15 0.33333333333333215,3.552713678800501E-15 0.6666666666666643,3.552713678800501E-15 0.3333333333333357,0.33333333333333215 a525 a526 a527 STATE_TRANSITION s497 s497 0.3333333333333339,-7.105427357601002E-15 0.6666666666666661,-7.105427357601002E-15 a523 a524 TRANSCRIPTIONAL_ACTIVATION s319 s307 0.3333333333333339,0.0 0.666666666666667,-8.881784197001252E-16 a533 a507 STATE_TRANSITION s494 s494 0.3333333333333339,0.0 0.6666666666666661,-8.881784197001252E-16 a493 a482 STATE_TRANSITION s328 s492 0.3333333333333428,4.440892098500626E-16 0.6666666666666572,4.440892098500626E-16 a546 a549 a547 a551 STATE_TRANSITION s492 s330 0.3333333333333286,0.0 0.6666666666666714,0.0 a547 a550 a548 a552 HETERODIMER_ASSOCIATION s492,s425 s334 0.3333333333333339,2.8421709430404007E-14 0.6666666666666679,1.4210854715202004E-14 0.3333333333333428,0.0 0.6666666666666714,1.7763568394002505E-15 0.3333333333333286,-7.105427357601002E-15 0.6666666666666643,-7.105427357601002E-15 0.3333333333333357,0.33333333333333215 a547 a559 a560 STATE_TRANSITION s496 s496 0.3333333333333286,-4.440892098500626E-16 0.6666666666666643,-4.440892098500626E-16 a562 a563 STATE_TRANSITION s496 s496 0.33333333333333304,0.0 0.6666666666666667,-1.1102230246251565E-16 a563 a564 HETERODIMER_ASSOCIATION s337,s320 s343 0.3333333333333428,-7.105427357601002E-15 0.6666666666666714,-7.105427357601002E-15 0.3333333333333357,-7.105427357601002E-15 0.6666666666666714,-7.105427357601002E-15 0.3333333333333357,1.7763568394002505E-15 0.6666666666666714,8.881784197001252E-16 0.3333333333333357,0.3333333333333286 a567 a566 a575 STATE_TRANSITION s343 s344 0.3333333333333357,-4.440892098500626E-16 0.6666666666666714,-6.661338147750939E-16 a575 a541 a579 a542 TRANSPORT s253 s250 0.3333333333333339,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 a406 a405 TRANSPORT s264 s319 0.33333333333333304,8.881784197001252E-16 0.6666666666666652,-8.881784197001252E-16 a527 a533 TRANSPORT s293 s300 0.3333333333333326,0.0 0.6666666666666661,2.220446049250313E-16 a486 a495 TRANSPORT s248 s249 0.33333333333333337,4.440892098500626E-16 0.6666666666666669,-4.440892098500626E-16 a403 a404 HETERODIMER_ASSOCIATION s392,s362 s370 0.3333333333333335,1.1102230246251565E-16 0.6666666666666667,-1.1102230246251565E-16 0.3333333333333335,4.440892098500626E-16 0.6666666666666665,4.440892098500626E-16 0.33333333333333326,-4.440892098500626E-16 0.6666666666666663,-4.440892098500626E-16 0.3333333333333335,0.33333333333333326 a2 a601 a615 STATE_TRANSITION s370 s384 0.3333333333333335,-3.3306690738754696E-16 0.666666666666667,-3.3306690738754696E-16 a615 a630 a629 a631 STATE_TRANSITION s386 s19 0.3333333333333357,-2.6645352591003757E-15 0.6666666666666679,-5.773159728050814E-15 a632 a25 HETERODIMER_ASSOCIATION s384,s404 s398 0.33333333333333304,-1.1102230246251565E-16 0.6666666666666661,3.3306690738754696E-16 0.33333333333333315,0.0 0.6666666666666653,-1.7763568394002505E-15 0.33333333333333215,0.0 0.6666666666666661,-4.440892098500626E-16 0.3333333333333328,0.3333333333333339 a629 a633 a648 STATE_TRANSITION s398 s437 0.33333333333333437,-1.3322676295501878E-15 0.6666666666666674,-2.4424906541753444E-15 a648 a668 a667 a669 HETERODIMER_ASSOCIATION s406,s204 s442 0.33333333333333215,1.7763568394002505E-15 0.6666666666666679,-1.7763568394002505E-15 0.3333333333333357,0.0 0.6666666666666679,0.0 0.3333333333333339,4.440892098500626E-16 0.6666666666666661,0.0 0.3333333333333329,0.3333333333333339 a275 a302 a305 a511 a682 HETERODIMER_ASSOCIATION s490,s415 s449 0.3333333333333357,0.0 0.6666666666666679,-3.552713678800501E-15 0.33333333333333215,0.0 0.6666666666666661,1.7763568394002505E-15 0.3333333333333339,0.0 0.6666666666666679,-1.7763568394002505E-15 0.33333333333333304,0.33333333333333215 a397 a400 a691 DISSOCIATION s449 s247,s490 0.33333333333333215,7.105427357601002E-15 0.6666666666666679,0.0 0.33333333333333215,3.552713678800501E-15 0.6666666666666679,3.552713678800501E-15 0.3333333333333286,1.7763568394002505E-15 0.6666666666666572,0.0 0.5817396602266411,-0.008934403748590114 a691 a692 a693 TRANSPORT s500 s494 0.3333333333333326,0.0 0.6666666666666665,-7.105427357601002E-15 a480 a493 HETERODIMER_ASSOCIATION s494,s294 s451 0.3333333333333428,0.0 0.6666666666666572,0.0 0.3333333333333286,1.4210854715202004E-14 0.6666666666666572,1.4210854715202004E-14 0.33333333333333215,0.0 0.6666666666666679,0.0 0.3333333333333286,0.33333333333333304 a482 a488 a699 STATE_TRANSITION s452 s452 0.3333333333333357,8.881784197001252E-16 0.6666666666666643,8.881784197001252E-16 a514 a516 STATE_TRANSITION s445 s494 0.33333333333333304,0.0 0.666666666666667,0.0 a517 a522 STATE_TRANSITION s464 s461 0.3333333333333339,-4.440892098500626E-16 0.6666666666666679,-8.881784197001252E-16 a720 a722 a717 a721 DISSOCIATION s461 s419,s455 0.3333333333333357,-3.552713678800501E-15 0.6666666666666679,-3.552713678800501E-15 0.33333333333333215,1.7763568394002505E-15 0.6666666666666679,1.7763568394002505E-15 0.3333333333333357,0.0 0.6666666666666679,1.7763568394002505E-15 0.3333333333333339,0.3333333333333339 a717 a729 a725 DISSOCIATION s492 s282,s281 0.33333333333333215,-7.105427357601002E-15 0.6666666666666679,-7.105427357601002E-15 0.3333333333333286,-7.105427357601002E-15 0.6666666666666572,-7.105427357601002E-15 0.3333333333333286,0.0 0.6666666666666643,0.0 0.3333333333333357,0.3333333333333357 a469 a471 a470 HETERODIMER_ASSOCIATION s425,s330 s335 0.3333333333333357,0.0 0.6666666666666714,3.552713678800501E-15 0.3333333333333286,-1.4210854715202004E-14 0.666666666666643,-7.105427357601002E-15 0.3333333333333286,0.0 0.6666666666666643,0.0 0.3333333333333357,0.3333333333333357 a559 a548 a561 HETERODIMER_ASSOCIATION s419,s408 s471 0.3333333333333357,0.0 0.6666666666666643,3.552713678800501E-15 0.3333333333333357,0.0 0.6666666666666679,0.0 0.3333333333333286,0.0 0.6666666666666643,-8.881784197001252E-16 0.3333333333333339,0.33333333333333215 a729 a425 a422 a421 a278 a743 DISSOCIATION s471 s477,s485 0.3333333333333357,0.0 0.6666666666666696,0.0 0.3333333333333428,3.552713678800501E-15 0.6666666666666572,3.552713678800501E-15 0.3333333333333286,0.0 0.6666666666666607,0.0 0.33333333333328596,0.3333333333333286 a743 a764 a294 a293 STATE_TRANSITION s498 s498 0.3333333333333286,-8.881784197001252E-16 0.6666666666666643,-1.7763568394002505E-15 a537 a765 KNOWN_TRANSITION_OMITTED s491 s496 0.33333333333333304,0.0 0.666666666666667,-1.7763568394002505E-15 a434 a513