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<![CDATA[
Boversion of vitamin B1, thiamin, into its coenzyme merely requires the addition of pyrophosphate to the thiamine, at the expense of ATP, by a pyrophosphate transferase.

Website=KEGG - Kyoto Encyclopedia of Genes and Genomes http://www.genome.jp/kegg/
free text=Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal
free text=Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm
free text=Human Metabolism by Ramsey Bronk
]]>
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<celldesigner:name>Pyruvate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c9" id="s284" initialAmount="0.0" name="Glyceraldehyde-3P">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Glyceraldehyde-3P
Synonym:  Synonym not specified
Accession:  S04206
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Glyceraldehyde-3P</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s285" initialAmount="0.0" name="Hydroxymethyl_br_pyrimidine kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Hydroxymethyl pyrimidine kinase
Synonym:  Synonym not specified
Accession:  P03181
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p90</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r153"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s287" initialAmount="0.0" name="Phosphomethyl_br_pyrimidine kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Phosphomethyl pyrimidine kinase
Synonym:  Hydroxymethylpyrimidine phosphokinase
Accession:  P03179
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p92</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r154"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s288" initialAmount="0.0" name="Hydroxyethyl_br_thiazole kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Hydroxyethyl thiazole kinase
Synonym:  Synonym not specified
Accession:  P03183
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p93</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r156"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s289" initialAmount="0.0" name="5-(2-Hydroxyethyl)-_br_4-methylthiazole">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  5-(2-Hydroxyethyl)-4-methylthiazole
Synonym:  Synonym not specified
Accession:  S04213
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>5-(2-Hydroxyethyl)-_br_4-methylthiazole</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s290" initialAmount="0.0" name="Thiamine_br_phosphate diphosphorylase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Thiamine phosphate diphosphorylase
Synonym:  Synonym not specified
Accession:  P03187
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p94</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s291" initialAmount="0.0" name="Thiamine_br_phosphate kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Thiamine phosphate kinase
Synonym:  Thiamine monophosphokinase
Accession:  P03178
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p95</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s292" initialAmount="0.0" name="Thiamine_br_triphosphatase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Thiamine triphosphatase
Synonym:  Synonym not specified
Accession:  P03184
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p96</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s294" initialAmount="0.0" name="Thiamine_br_diphosphate kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Thiamine diphosphate kinase
Synonym:  Thiamine pyrophosphate kinase
Accession:  P03177
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p98</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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<celldesigner:catalyzed reaction="r169"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s295" initialAmount="0.0" name="Nucleoside_br_triphosphatase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Nucleoside triphosphatase
Synonym:  Synonym not specified
Accession:  P03180
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p99</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s296" initialAmount="0.0" name="Thiamine_br_kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Thiamine kinase
Synonym:  Synonym not specified
Accession:  P03176
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p100</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s297" initialAmount="0.0" name="Thiamine_br_oxidase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Thiamine oxidase
Synonym:  Thiamine dehydrogenase
Accession:  P03186
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p101</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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<celldesigner:catalyzed reaction="r164"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s298" initialAmount="0.0" name="Thiamine_br_pyridinylase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Thiamine pyridinylase
Synonym:  Synonym not specified
Accession:  P03182
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p102</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
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</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s299" initialAmount="0.0" name="Thiaminase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Thiaminase
Synonym:  Synonym not specified
Accession:  P03185
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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</annotation>
</species>
</listOfSpecies>
<listOfReactions>
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<annotation>
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<celldesigner:baseReactants>s264</celldesigner:baseReactants>
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</annotation>
<listOfReactants>
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<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<annotation>
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</celldesigner:listOfModification>
</annotation>
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<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
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<annotation>
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</speciesReference>
</listOfProducts>
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<annotation>
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<annotation>
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<annotation>
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<annotation>
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