2.3 SQUARE SQUARE SQUARE SQUARE SQUARE_CLOSEUP_SOUTH inactive inactive inactive inactive inactive active inactive active inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive Endoplasmic Reticulum Secretory Vesicle Adenohypophysis cells (anterior pituitary) Parvocellular cells in Paraventricular Nucleus of Hypothalamus (release of TRH from Median Eminence) Long Name: ProTRH (Pro Thyrotropin-releasing Hormone) Synonym: Pro Thyrotropin-releasing Hormone Accession: P04586 inside PROTEIN p1 Long Name: TRH Synonym: Synonym not specified Accession: P04585 inside PROTEIN p2 Long Name: GDP Synonym: Synonym not specified Accession: S04856 inside SIMPLE_MOLECULE GDP Long Name: GTP Synonym: Synonym not specified Accession: S04853 inside SIMPLE_MOLECULE GTP Long Name: DAG Synonym: Synonym not specified Accession: S04855 inside SIMPLE_MOLECULE DAG Long Name: Long name not specified Synonym: Synonym not specified Accession: U05558 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S04853##;G-Protein#PROTEIN#G-Protein#P04584## inside SIMPLE_MOLECULE GTP PROTEIN p8 Long Name: Ca2+ Synonym: Synonym not specified Accession: U05559 inside ION Ca_super_2+ Long Name: PIP2 Synonym: Synonym not specified Accession: S04852 inside SIMPLE_MOLECULE PIP2 Long Name: IP3 Synonym: Synonym not specified Accession: S04854 inside SIMPLE_MOLECULE IP_sub_3 Long Name: SNARE COMPLEX Synonym: Synonym not specified Accession: P04582 transmembrane PROTEIN p11 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05554 Heterodimer Member Info: TRH Receptor#PROTEIN#TRH Receptor#P04580#TRH Receptor 1|TRH Receptor 2|Thyrotropin-releasing hormone Receptor#;G-Protein#PROTEIN#G-Protein#P04584##;GDP#SIMPLE_MOLECULE#GDP#S04856## transmembrane SIMPLE_MOLECULE GDP PROTEIN p8 PROTEIN p3 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05557 Heterodimer Member Info: TRH Receptor#PROTEIN#TRH Receptor#P04580#TRH Receptor 1|TRH Receptor 2|Thyrotropin-releasing hormone Receptor#;G-Protein#PROTEIN#G-Protein#P04584##;TRH#PROTEIN#TRH#P04585##;GDP#SIMPLE_MOLECULE#GDP#S04856## transmembrane SIMPLE_MOLECULE GDP PROTEIN p8 PROTEIN p3 PROTEIN p2 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05555 Heterodimer Member Info: TRH Receptor#PROTEIN#TRH Receptor#P04580#TRH Receptor 1|TRH Receptor 2|Thyrotropin-releasing hormone Receptor#;TRH#PROTEIN#TRH#P04585## transmembrane PROTEIN p3 PROTEIN p2 Long Name: TRH Synonym: Synonym not specified Accession: P04585 inside PROTEIN p2 Long Name: PLC Synonym: Synonym not specified Accession: P04581 inside PROTEIN p6 Long Name: Ca2+ Synonym: Synonym not specified Accession: U05559 inside ION Ca_super_2+ Long Name: PKC Synonym: protein kinase C Accession: P04583 inside PROTEIN p9 Long Name: Thyrotropin Synonym: TSH,Thyroid Stimulating Hormone Accession: P04588 inside PROTEIN p5 Long Name: Thyrotropin Synonym: TSH,Thyroid Stimulating Hormone Accession: P04588 inside PROTEIN p5 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05556 Heterodimer Member Info: Ca2+#ION#Ca2+#U05559##;SNARE COMPLEX#PROTEIN#SNARE COMPLEX#P04582## transmembrane PROTEIN p11 ION Ca_super_2+ Long Name: Thyroid hormone release Synonym: Synonym not specified Accession: U05560 inside PHENOTYPE Thyroid hormone_br_release Long Name: Ca2+ channel Synonym: Synonym not specified Accession: P04587 transmembrane PROTEIN p10 DISSOCIATION s15 s16,s9 0.33333333333333215,0.0 0.6666666666666645,0.0 0.33333333333333215,-1.7763568394002505E-15 0.6666666666666661,-1.7763568394002505E-15 0.3333333333333357,0.0 0.6666666666666643,0.0 0.4354581648691984,0.1831749411499608 a18 a19 a10 a9 STATE_TRANSITION s32 s32 0.33333333333333304,0.0 0.6666666666666661,-8.881784197001252E-16 a20 a21 a10 STATE_TRANSITION s31 s31 0.33333333333333304,3.1086244689504383E-15 0.6666666666666663,6.661338147750939E-15 a17 a15 a21 TRANSPORT s13 s30 -0.059944063581688134,-0.38871224597285714 0.8829312644053537,-0.2938221570569781 a16 a14 a15 STATE_TRANSITION s29 s29 0.33333333333333326,0.0 0.6666666666666665,0.0 a8 a9 a11 UNKNOWN_TRANSITION s1 s28 0.33333333333333326,2.498001805406602E-16 0.6666666666666665,4.996003610813204E-16 a1 a35 TRANSPORT s28 s2 0.20935732417113573,-0.19463412594131402 0.7982302942998896,-0.5498517859151928 a35 a2 a34 HETERODIMER_ASSOCIATION s2,s24 s26 0.3333333333333337,0.0 0.6666666666666663,0.0 0.3333333333333339,0.0 0.6666666666666661,-3.552713678800501E-15 0.3333333333333335,0.0 0.6666666666666667,0.0 -0.5606634197647082,0.7551017493773848 a2 a37 a40 DISSOCIATION s26 s27,s10 0.3333333333333335,0.0 0.6666666666666667,4.440892098500626E-16 0.3333333333333339,-4.440892098500626E-16 0.666666666666667,-4.440892098500626E-16 0.3333333333333337,0.0 0.6666666666666665,0.0 0.33333333333333304,0.33333333333333304 a40 a7 a41 a11 a6 TRANSPORT s34 s35 0.14012611529203234,-0.1076972545598083 0.72174299981641,-0.5733218091177936 a46 a45 a51 HETERODIMER_ASSOCIATION s30,s22 s40 0.33333333333333304,0.0 0.666666666666667,0.0 0.3333333333333339,0.0 0.6666666666666661,0.0 0.33333333333333326,0.0 0.6666666666666659,0.0 0.3333333333333335,0.33333333333333337 a14 a43 a51 KNOWN_TRANSITION_OMITTED s35 s41 0.3333333333333339,8.881784197001252E-16 0.666666666666667,-8.881784197001252E-16 a45 a52