<?xml version="1.0" encoding="UTF-8"?>
<!-- Terms and Conditions -->
<!-- 
Copyright (C) 2007 SRI International.  All Rights Reserved.
This file may be copied and redistributed freely, without advance
permission, provided that these notices are reproduced with each
copy.  Your use of the data herein is solely at your own risk.
The data is not, and is not supplied as, medical information.

THIS DATA IS PROVIDED "AS IS" AND WITHOUT ANY EXPRESS OR IMPLIED
WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES
OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. IN NO
EVENT SHALL SRI BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL,
SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT
LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF
USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND
ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,
OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT
OF THE USE OF THIS DATA, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH
DAMAGE.
-->

<!-- Created by SBML API 2.0(a17.0) -->
<sbml level="2" version="1" xmlns="http://www.sbml.org/sbml/level2" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner">
<model id="Tyrosine_space_biosynthesis">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
<![CDATA[
Biosynthesis of the aromatic amino acid tyrosine involved in protein biosynthesis.
Website=www.biocyc.org/Ecoli
Website=www.biocyc.org/Ecoli/Pathways/
free text=Biochemistry (text)  Voet and Voet
]]>
</body>
</html>
</notes>
<annotation>
<celldesigner:modelVersion>2.3</celldesigner:modelVersion>
<celldesigner:modelDisplay sizeX="600" sizeY="400"/>
<celldesigner:listOfCompartmentAliases/>
<celldesigner:listOfSpeciesAliases>
<celldesigner:speciesAlias id="a1" species="s1">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="28.0" w="96.0" x="185.0" y="14.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a2" species="s2">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="34.0" w="84.0" x="193.0" y="109.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a3" species="s3">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="35.0" w="146.0" x="163.0" y="231.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a4" species="s4">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="37.0" w="97.0" x="187.0" y="357.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a5" species="s5">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="18.0" w="35.0" x="147.0" y="143.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a6" species="s6">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="17.0" w="41.0" x="145.0" y="188.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a7" species="s7">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="22.0" w="48.0" x="120.0" y="216.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a8" species="s8">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="21.0" w="60.0" x="142.0" y="266.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a9" species="s9">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="20.0" w="82.0" x="120.0" y="337.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffffffff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a10" species="s10">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="26.0" w="116.0" x="321.0" y="63.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ff66ccff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a11" species="s11">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="32.0" w="100.0" x="333.0" y="170.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ff66ccff" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="a12" species="s12">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="34.0" w="127.0" x="314.0" y="294.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ff66ccff" scheme="Color"/>
</celldesigner:speciesAlias>
</celldesigner:listOfSpeciesAliases>
<celldesigner:listOfGroups/>
<celldesigner:listOfProteins>
<celldesigner:protein id="p1" name="Chorismate mutase" type="GENERIC"/>
<celldesigner:protein id="p2" name="Prephenate_br_dehydrogenase" type="GENERIC"/>
<celldesigner:protein id="p3" name="Aromatic amino_br_acid aminotransferase" type="GENERIC"/>
</celldesigner:listOfProteins>
<celldesigner:listOfBlockDiagrams/>
</annotation>
<listOfCompartments>
<compartment id="default" size="1.0"/>
</listOfCompartments>
<listOfSpecies>
<species compartment="default" id="s1" initialAmount="0.0" name="chorismate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  chorismate
Synonym:  Synonym not specified
Accession:  S04274
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>chorismate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s2" initialAmount="0.0" name="prephenate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  prephenate
Synonym:  Synonym not specified
Accession:  S04273
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>prephenate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s3" initialAmount="0.0" name="P-hydroxyphenylpyruvate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  P-hydroxyphenylpyruvate
Synonym:  Synonym not specified
Accession:  S04272
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>P-hydroxyphenylpyruvate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s4" initialAmount="0.0" name="tyrosine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  tyrosine
Synonym:  Synonym not specified
Accession:  S04277
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>tyrosine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s5" initialAmount="0.0" name="NAD">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NAD
Synonym:  Synonym not specified
Accession:  S04269
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NAD</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s6" initialAmount="0.0" name="NADH">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  NADH
Synonym:  Synonym not specified
Accession:  S04270
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>NADH</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s7" initialAmount="0.0" name="CO_sub_2">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  CO2
Synonym:  Synonym not specified
Accession:  S04271
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>CO_sub_2</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s8" initialAmount="0.0" name="glutamate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  glutamate
Synonym:  Synonym not specified
Accession:  S04276
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>glutamate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s9" initialAmount="0.0" name="ketoglutarate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ketoglutarate
Synonym:  Synonym not specified
Accession:  S04275
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ketoglutarate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s10" initialAmount="0.0" name="Chorismate mutase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Chorismate mutase
Synonym:  Synonym not specified
Accession:  P03212
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r1"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s11" initialAmount="0.0" name="Prephenate_br_dehydrogenase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Prephenate dehydrogenase
Synonym:  Synonym not specified
Accession:  P03214
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r2"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s12" initialAmount="0.0" name="Aromatic amino_br_acid dehydrogenase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Aromatic amino acid aminotransferase
Synonym:  Synonym not specified
Accession:  P03213
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r3"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction id="r1" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s1</celldesigner:baseReactants>
<celldesigner:baseProducts>s2</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333333,-8.881784197001252E-16 0.6666666666666667,-4.440892098500626E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a10" editPoints="0.33333333333333304,-5.551115123125783E-16 0.666666666666667,-1.1102230246251565E-15" modifiers="s10" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s1">
<annotation>
<celldesigner:alias>a1</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s2">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s10">
<annotation>
<celldesigner:alias>a10</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r2" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s2</celldesigner:baseReactants>
<celldesigner:baseProducts>s3</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a5" reactant="s5" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a6" product="s6" targetLineIndex="-1,1"/>
<celldesigner:productLink alias="a7" product="s7" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333326,-4.440892098500626E-16 0.6666666666666665,-8.881784197001252E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a11" editPoints="0.33333333333333304,-4.440892098500626E-16 0.666666666666667,-1.3322676295501878E-15" modifiers="s11" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s2">
<annotation>
<celldesigner:alias>a2</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s5">
<annotation>
<celldesigner:alias>a5</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s3">
<annotation>
<celldesigner:alias>a3</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s6">
<annotation>
<celldesigner:alias>a6</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s7">
<annotation>
<celldesigner:alias>a7</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s11">
<annotation>
<celldesigner:alias>a11</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r3" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s3</celldesigner:baseReactants>
<celldesigner:baseProducts>s4</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a8" reactant="s8" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a9" product="s9" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333304,0.0 0.6666666666666665,0.0</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a12" editPoints="0.33333333333333304,4.440892098500626E-16 0.6666666666666665,0.0" modifiers="s12" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s3">
<annotation>
<celldesigner:alias>a3</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s8">
<annotation>
<celldesigner:alias>a8</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s4">
<annotation>
<celldesigner:alias>a4</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s9">
<annotation>
<celldesigner:alias>a9</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="s12">
<annotation>
<celldesigner:alias>a12</celldesigner:alias>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
</listOfReactions>
</model>
</sbml>


