2.3 inactive inactive inactive inactive inactive active active inactive active inactive inactive active inactive active inactive inactive inactive inactive inactive inactive active inactive active active inactive inactive inactive inactive active inactive inactive active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Long Name: AMP Synonym: Synonym not specified Accession: S04875 inside SIMPLE_MOLECULE AMP Long Name: AMP-activated protein kinase Synonym: Synonym not specified Accession: P04639 inside PROTEIN p1 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05675 Heterodimer Member Info: AMPK#PROTEIN#AMP-activated protein kinase#P04639##;AMP#SIMPLE_MOLECULE#AMP#S04875## inside SIMPLE_MOLECULE AMP PROTEIN p1 Long Name: AMP-activated protein kinase Synonym: Synonym not specified Accession: P04639 inside PROTEIN p1 Long Name: Serine/threonine protein kinase 11 Synonym: STK11 Accession: P04647 inside PROTEIN p2 Long Name: TSC1 Synonym: Tuberous sclerosis-1 Accession: P04645 inside PROTEIN p4 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05677 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S04874##;Rheb#PROTEIN#Ras homolog enriched in brain 2#P04642## inside PROTEIN p5 SIMPLE_MOLECULE GTP Long Name: Long name not specified Synonym: Synonym not specified Accession: U05674 Heterodimer Member Info: GDP#SIMPLE_MOLECULE#GDP#S04872##;Rheb#PROTEIN#Ras homolog enriched in brain 2#P04642## inside PROTEIN p5 SIMPLE_MOLECULE GDP Long Name: Target of rapamycin Synonym: FKBP12-rapamycin complex associated protein 1,FRAP1,TOR Accession: P04638 inside PROTEIN p6 Long Name: S6K Synonym: Ribosomal protein S6 kinase Accession: P04636 inside PROTEIN p7 Long Name: S6K Synonym: Ribosomal protein S6 kinase Accession: P04636 inside PROTEIN p7 Long Name: Eukaryotic translation initiation factor 4E-binding protein 1 Synonym: EIF4EBP1 Accession: P04637 inside PROTEIN p8 Long Name: Eukaryotic translation initiation factor 4E-binding protein 1 Synonym: EIF4EBP1 Accession: P04637 inside PROTEIN p8 Long Name: Translation Synonym: Synonym not specified Accession: U05679 inside PHENOTYPE Translation Long Name: Autophagy Synonym: Synonym not specified Accession: U05683 inside PHENOTYPE Autophagy Long Name: Protein phosphatase 2 catalytic subunit Synonym: Synonym not specified Accession: P04643 inside PROTEIN p10 Long Name: p53 Synonym: Synonym not specified Accession: P04640 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04668|p53 pathway feedback loops 2*P00059|P01485|p53 pathway inside PROTEIN p11 Long Name: p53 Synonym: Synonym not specified Accession: P04640 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04668|p53 pathway feedback loops 2*P00059|P01485|p53 pathway inside PROTEIN p11 Long Name: TSC2 Synonym: Synonym not specified Accession: G04706 inside GENE TSC2 Long Name: Low glucose Synonym: Synonym not specified Accession: U05678 inside PHENOTYPE Low glucose Long Name: ATP Synonym: Synonym not specified Accession: S04873 inside SIMPLE_MOLECULE ATP Long Name: Long name not specified Synonym: Synonym not specified Accession: U05672 Heterodimer Member Info: ATP#SIMPLE_MOLECULE#ATP#S04873##;AMPK#PROTEIN#AMP-activated protein kinase#P04639## inside PROTEIN p1 SIMPLE_MOLECULE ATP Long Name: Pi Synonym: Synonym not specified Accession: U05682 inside ION Pi Long Name: alpha4 Synonym: Synonym not specified Accession: P04646 inside PROTEIN p9 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05676 Heterodimer Member Info: PP2A-C#PROTEIN#Protein phosphatase 2 catalytic subunit#P04643##;alpha4#PROTEIN#alpha4#P04646## inside PROTEIN p9 PROTEIN p10 Long Name: Akt Synonym: ONCOGENE AKT1,ONCOGENE AKT2,PKB,PKB-ALPHA,PKB-BETA,PROTEIN KINASE B-ALPHA,PROTEIN KINASE B-BETA,RAC SERINE/THREONINE PROTEIN KINASE Accession: P04641 Pathway Link: P00033|P00894|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04665|p53 pathway feedback loops 2*P00059|P01486|p53 pathway inside PROTEIN p12 Long Name: Insulin singaling pathway Synonym: Synonym not specified Accession: U05681 inside PHENOTYPE Insulin singaling pathway Long Name: TSC2 Synonym: Synonym not specified Accession: P04644 inside PROTEIN p3 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05673 Heterodimer Member Info: TSC2#PROTEIN#TSC2#P04644##;TSC1#PROTEIN#TSC1#P04645#Tuberous sclerosis-1# inside PROTEIN p3 PROTEIN p4 Long Name: TSC2 Synonym: Synonym not specified Accession: P04644 inside PROTEIN p3 Long Name: p53 pathway Synonym: Synonym not specified Accession: U05680 inside PHENOTYPE p53 pathway HETERODIMER_ASSOCIATION s1,s2 s4 0.3333333333333339,4.440892098500626E-16 0.666666666666667,2.220446049250313E-16 0.3333333333333335,4.440892098500626E-16 0.6666666666666665,0.0 0.3333333333333339,0.0 0.6666666666666665,0.0 0.3333333333333334,0.3333333333333335 a4 a5 a8 STATE_TRANSITION s4 s5 0.33333333333333304,0.0 0.6666666666666665,4.440892098500626E-16 a8 a9 a10 STATE_TRANSITION s7 s36 0.3333333333333339,0.0 0.6666666666666679,8.881784197001252E-16 a11 a12 a9 HETERODIMER_ASSOCIATION s36,s9 s11 0.3333333333333339,0.0 0.6666666666666661,0.0 0.33333333333333304,0.0 0.6666666666666665,0.0 0.3333333333333339,1.7763568394002505E-15 0.6666666666666661,0.0 0.3333333333333326,0.3333333333333348 a12 a13 a17 STATE_TRANSITION s15 s16 0.3333333333333339,0.0 0.6666666666666679,0.0 a22 a23 a46 a17 STATE_TRANSITION s17 s17 0.33333333333333304,0.0 0.6666666666666661,0.0 a24 a25 a22 STATE_TRANSITION s19 s18 0.33333333333333304,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 a26 a27 a25 STATE_TRANSITION s20 s21 0.33333333333333304,8.881784197001252E-16 0.6666666666666661,0.0 a28 a29 a25 KNOWN_TRANSITION_OMITTED s18 s22 0.33333333333333215,0.0 0.6666666666666661,0.0 a27 a30 UNKNOWN_INHIBITION s20 s22 0.3486152123103632,-0.14203792276709537 0.6755339297767953,-0.09700085086124677 a28 a30 UNKNOWN_INHIBITION s17 s23 0.33333333333333304,-4.440892098500626E-16 0.6666666666666665,0.0 a25 a31 UNKNOWN_TRANSITION s24 s24 0.33333333333333304,1.7763568394002505E-15 0.666666666666667,1.7763568394002505E-15 a32 a33 a25 HETERODIMER_ASSOCIATION s24,s25 s26 0.3333333333333357,-5.689893001203927E-16 0.6666666666666679,-5.689893001203927E-16 0.3333333333333304,-3.552713678800501E-15 0.6666666666666643,-3.552713678800501E-15 0.33333333333333215,3.552713678800501E-15 0.6666666666666679,0.0 0.3333333333333339,0.33333333333333215 a33 a34 a37 STATE_TRANSITION s27 s28 0.3333333333333339,-1.7763568394002505E-15 0.6666666666666679,0.0 a38 a39 a37 STATE_TRANSITION s28 s27 0.33333333333333215,0.0 0.6866661126653977,1.0526024209411844E-4 a39 a38 a9 TRANSCRIPTIONAL_ACTIVATION s27 s29 -0.0658276114298979,-0.08170528533750954 0.6652427002756118,-0.033609558477993184 a38 a40 KNOWN_TRANSITION_OMITTED s30 s1 0.5759975133906753,0.33519080986337835 0.7945454522004819,0.1883993484258139 a41 a4 HETERODIMER_ASSOCIATION s31,s2 s32 0.3333333333333339,0.0 0.666666666666667,-2.220446049250313E-16 0.3333333333333339,-2.220446049250313E-16 0.666666666666667,-2.220446049250313E-16 0.3333333333333335,8.881784197001252E-16 0.666666666666667,0.0 0.33333333333333326,0.3333333333333334 a42 a5 a45 KNOWN_TRANSITION_OMITTED s29 s7 -0.02922472058974135,-0.14548648726903035 1.0281402577015732,-0.13989571257371536 a40 a11 DISSOCIATION s11 s36,s9 0.3333333333333339,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 0.33333333333333215,8.881784197001252E-16 0.6666666666666661,0.0 0.33333333333333504,-3.552713678800501E-15 0.6666666666666673,-1.7763568394002505E-15 0.33333333333333304,0.3333333333333337 a17 a12 a13 a47 KNOWN_TRANSITION_OMITTED s35 s34 0.11691663980483025,0.9108856823223821 0.8081634716876209,0.42365611786343926 a48 a47 KNOWN_TRANSITION_OMITTED s27 s37 0.33333333333333304,0.0 0.666666666666667,8.881784197001252E-16 a38 a49