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<![CDATA[
The cadherin gene family encode proteins that mediate calcium-ion-dependent adhesion. Three members of this family are E-cadherin, N-cadherin, and P-cadherin.  Cadherin-catenin complex is the central part of this pathway.  It's been shown that the pathway is involved in many biological processes, such as development, neurogenesis, cell adhesion, and inflammation.  It has also been implicated to ve involved in many disease, such as cancer.  In this pathway, we focus on Cadherin signaling pathway.  For Wnt pathway, please see our "Wnt signaling pathway".
Medline=12841864 
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Medline=15001769
Medline=7502046 
OMIM=114020
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<celldesigner:speciesAlias compartmentAlias="ca1" id="a169" species="s1">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="54.0" w="90.0" x="945.2696877380062" y="141.5"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a170" species="s119">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="54.0" w="90.0" x="1007.5619954303107" y="304.5"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a172" species="s3">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="54.0" w="90.0" x="1075.6658415841584" y="552.3788667551587"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a173" species="s120">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="54.0" w="90.0" x="1306.6658415841584" y="597.6211332448415"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
<celldesigner:speciesAlias compartmentAlias="ca1" id="a174" species="s121">
<celldesigner:activity>inactive</celldesigner:activity>
<celldesigner:bounds h="54.0" w="90.0" x="1156.1658415841584" y="630.5229082033835"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
</celldesigner:speciesAlias>
</celldesigner:listOfSpeciesAliases>
<celldesigner:listOfGroups/>
<celldesigner:listOfProteins>
<celldesigner:protein id="p6" name="GSK3_beta_" type="GENERIC"/>
<celldesigner:protein id="p8" name="Src" type="GENERIC"/>
<celldesigner:protein id="p9" name="EGFR" type="RECEPTOR"/>
<celldesigner:protein id="p2" name="_alpha_catenin" type="GENERIC"/>
<celldesigner:protein id="p4" name="F_minus_actin" type="GENERIC"/>
<celldesigner:protein id="p10" name="Fyn" type="GENERIC"/>
<celldesigner:protein id="p11" name="Yes" type="GENERIC"/>
<celldesigner:protein id="p12" name="Casein kinase II" type="GENERIC"/>
<celldesigner:protein id="p7" name="Fer" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue id="rs1" name="Y"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p1" name="Cadherin" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="3.14" id="rs1" name="Y"/>
<celldesigner:modificationResidue angle="0.09" id="rs2" name="S/T"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p3" name="_beta_catenin" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="3.3479165476195107" id="rs1" name="Y654"/>
<celldesigner:modificationResidue angle="2.893781136851091" id="rs2" name="Y142"/>
<celldesigner:modificationResidue angle="-0.0" id="rs3" name="T112"/>
<celldesigner:modificationResidue angle="1.6575346654708816" id="rs4" name="S"/>
<celldesigner:modificationResidue angle="4.653633157668967" id="rs5"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p5" name="P120" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="3.14" id="rs1"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="p14" name="TCF_slash_LEF" type="GENERIC"/>
<celldesigner:protein id="p15" name="Frizzled" type="RECEPTOR"/>
<celldesigner:protein id="p16" name="Wnt" type="GENERIC"/>
<celldesigner:protein id="p13" name="Tyrosine_br_phosphatases" type="GENERIC"/>
</celldesigner:listOfProteins>
<celldesigner:listOfBlockDiagrams/>
</annotation>
<listOfCompartments>
<compartment name="default" volume="1.0"/>
<compartment name="c1" outside="default" volume="1.0">
<annotation>
<celldesigner:name>Cytoplasm</celldesigner:name>
</annotation>
</compartment>
<compartment name="c2" outside="c1" volume="1.0">
<annotation>
<celldesigner:name>nucleus</celldesigner:name>
</annotation>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species compartment="c1" initialAmount="0.0" name="s6">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Glycogen synthase kinase 3-beta
Synonym:  GSK3B
Accession:  P00477
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r25"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s8">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Src tyrosine kinase
Synonym:  Synonym not specified
Accession:  P00468
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r21"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s9">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Epidermal growth factor receptor
Synonym:  Synonym not specified
Accession:  P00466
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r21"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s22">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Cell Adhesion
Synonym:  Synonym not specified
Accession:  U02192
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Cell Adhesion</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s31">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Fyn tyrosine kinase protooncogene
Synonym:  Syn
Accession:  P00464
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r21"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s32">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Oncogene YES1
Synonym:  Yamaguchi sarcoma oncogene
Accession:  P00476
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r12"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s54">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05138
Heterodimer Member Info:  alphacatenin#PROTEIN#Alpha-catenin#P00467#Cadherin-associated protein#;F-actin#PROTEIN#Filamentous F-actin#P00470##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s63">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Casein kinase II
Synonym:  Synonym not specified
Accession:  P00462
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p12</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r17"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s7">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  FPS/FES-related tyrosine kinase
Synonym:  Protein tyrosine kinase 3,TYK3
Accession:  P00469
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s64">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  FPS/FES-related tyrosine kinase
Synonym:  Protein tyrosine kinase 3,TYK3
Accession:  P00469
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r43"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s1">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Cadherin
Synonym:  Synonym not specified
Accession:  P00471
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s3">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Beta-catenin
Synonym:  Synonym not specified
Accession:  P00463
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s41">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05132
Heterodimer Member Info:  betacatenin#PROTEIN#Beta-catenin#P00463##;alphacatenin#PROTEIN#Alpha-catenin#P00467#Cadherin-associated protein#;F-actin#PROTEIN#Filamentous F-actin#P00470##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s53">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05133
Heterodimer Member Info:  betacatenin#PROTEIN#Beta-catenin#P00463##;Cadherin#PROTEIN#Cadherin#P00471##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s72">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05137
Heterodimer Member Info:  betacatenin#PROTEIN#Beta-catenin#P00463##;alphacatenin#PROTEIN#Alpha-catenin#P00467#Cadherin-associated protein#;F-actin#PROTEIN#Filamentous F-actin#P00470##;Cadherin#PROTEIN#Cadherin#P00471##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs3" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner4" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s77">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05136
Heterodimer Member Info:  betacatenin#PROTEIN#Beta-catenin#P00463##;alphacatenin#PROTEIN#Alpha-catenin#P00467#Cadherin-associated protein#;F-actin#PROTEIN#Filamentous F-actin#P00470##;Cadherin#PROTEIN#Cadherin#P00471##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner3" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s93">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Beta-catenin
Synonym:  Synonym not specified
Accession:  P00463
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs4" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s94">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Beta-catenin
Synonym:  Synonym not specified
Accession:  P00463
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs4" state="phosphorylated"/>
<celldesigner:modification residue="rs5" state="ubiquitinated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s95">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  a133_degraded
Synonym:  Synonym not specified
Accession:  U02190
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>DEGRADED</celldesigner:class>
<celldesigner:name>a133_degraded</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s98">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05139
Heterodimer Member Info:  Cadherin#PROTEIN#Cadherin#P00471##;P120#PROTEIN#Delta-catenin#P00473#CAS|CTNND|Cadherin-associated Src substrate#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s99">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Endocytosis
Synonym:  Synonym not specified
Accession:  U02193
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Endocytosis</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s103">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Frizzled
Synonym:  Synonym not specified
Accession:  P00475
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s106">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05131
Heterodimer Member Info:  Wnt#PROTEIN#Wnt#P00474##;Frizzled#PROTEIN#Frizzled#P00475##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p16</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p15</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r39"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" initialAmount="0.0" name="s107">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Wnt
Synonym:  Synonym not specified
Accession:  P00474
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p16</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" initialAmount="0.0" name="s108">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05135
Heterodimer Member Info:  betacatenin#PROTEIN#Beta-catenin#P00463##;TCF/LEF#PROTEIN#Transcription factor 4/Lymphoid enhancer-binding factor#P00465##
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p14</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
</annotation>
</species>
<species compartment="c2" initialAmount="0.0" name="s100">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Wnt Targetz transcription
Synonym:  Synonym not specified
Accession:  U02191
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Wnt Targetz_br_transcription</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s110">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Delta-catenin
Synonym:  CAS,CTNND,Cadherin-associated Src substrate
Accession:  P00473
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" initialAmount="0.0" name="s111">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Beta-catenin
Synonym:  Synonym not specified
Accession:  P00463
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s112">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Beta-catenin
Synonym:  Synonym not specified
Accession:  P00463
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs2" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s113">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Alpha-catenin
Synonym:  Cadherin-associated protein
Accession:  P00467
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s114">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Filamentous F-actin
Synonym:  Synonym not specified
Accession:  P00470
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p4</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c2" initialAmount="0.0" name="s116">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Transcription factor 4/Lymphoid enhancer-binding factor
Synonym:  Synonym not specified
Accession:  P00465
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p14</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s119">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Beta-catenin
Synonym:  Synonym not specified
Accession:  P00463
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s121">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Delta-catenin
Synonym:  CAS,CTNND,Cadherin-associated Src substrate
Accession:  P00473
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s83">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Long Name:  Long name not specified
Synonym:  Synonym not specified
Accession:  U05134
Heterodimer Member Info:  betacatenin#PROTEIN#Beta-catenin#P00463##;Tyrosine phosphatases#PROTEIN#Protein-tyrosine phosphatases, non-receptor type 1#P00472#PTP1B|PTPN1|Protein phosphotyrosylphosphatase 1B#;P120#PROTEIN#Delta-catenin#P00473#CAS|CTNND|Cadherin-associated Src substrate#
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:heterodimerIdentity>
<celldesigner:listOfHeterodimerEntries>
<celldesigner:heterodimerEntry innerId="inner0" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p3</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner1" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
<celldesigner:heterodimerEntry innerId="inner2" originalSpecies="unknown">
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p5</celldesigner:proteinReference>
</celldesigner:heterodimerEntry>
</celldesigner:listOfHeterodimerEntries>
</celldesigner:heterodimerIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r17"/>
<celldesigner:catalyzed reaction="r42"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="c1" initialAmount="0.0" name="s120">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Protein-tyrosine phosphatases, non-receptor type 1
Synonym:  PTP1B,PTPN1,Protein phosphotyrosylphosphatase 1B
Accession:  P00472
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p13</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction name="r12" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s7</celldesigner:baseReactants>
<celldesigner:baseProducts>s64</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,0.0 0.666666666666667,-4.440892098500626E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a49" editPoints="0.3333333333333335,0.0 0.666666666666667,0.0" modifiers="s32" targetLineIndex="-1,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s7">
<annotation>
<celldesigner:alias>a94</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s64">
<annotation>
<celldesigner:alias>a7</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r16" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s72</celldesigner:baseReactants>
<celldesigner:baseProducts>s22</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333354,8.881784197001252E-16 0.6666666666666667,8.881784197001252E-16</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s72">
<annotation>
<celldesigner:alias>a103</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s22">
<annotation>
<celldesigner:alias>a30</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r17" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s53,s54</celldesigner:baseReactants>
<celldesigner:baseProducts>s72</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,-8.881784197001252E-16 0.6666666666666661,-6.661338147750939E-16 0.3333333333333326,-8.881784197001252E-16 0.6666666666666665,-8.881784197001252E-16 0.33333333333333215,0.0 0.6666666666666661,-4.440892098500626E-16 0.3333333333333335,0.3333333333333326</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a118" editPoints="0.3333333333333332,2.220446049250313E-16 0.6666666666666664,2.220446049250313E-16" modifiers="s83" targetLineIndex="2,1" type="CATALYSIS"/>
<celldesigner:modification aliases="a93" editPoints="0.3333333333333335,0.0 0.6666666666666665,1.7763568394002505E-15" modifiers="s63" targetLineIndex="2,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s53">
<annotation>
<celldesigner:alias>a82</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s54">
<annotation>
<celldesigner:alias>a83</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s72">
<annotation>
<celldesigner:alias>a103</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r21" reversible="false">
<annotation>
<celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s77</celldesigner:baseReactants>
<celldesigner:baseProducts>s53,s54</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333339,2.220446049250313E-16 0.666666666666667,4.440892098500626E-16 0.33333333333333304,8.881784197001252E-16 0.6666666666666652,8.881784197001252E-16 0.33333333333333304,-1.1102230246251565E-16 0.6666666666666661,-3.3306690738754696E-16 0.4060209233517805,0.2759407961642659</celldesigner:editPoints>
<celldesigner:listOfModification>
<celldesigner:modification aliases="a9" editPoints="0.3333333333333335,6.661338147750939E-16 0.6666666666666665,0.0" modifiers="s9" targetLineIndex="0,0" type="CATALYSIS"/>
<celldesigner:modification aliases="a48" editPoints="0.33333333333333304,0.0 0.6666666666666665,-2.220446049250313E-16" modifiers="s31" targetLineIndex="0,2" type="CATALYSIS"/>
<celldesigner:modification aliases="a8" editPoints="0.3333333333333339,1.7763568394002505E-15 0.6666666666666665,0.0" modifiers="s8" targetLineIndex="0,1" type="CATALYSIS"/>
</celldesigner:listOfModification>
</annotation>
<listOfReactants>
<speciesReference species="s77">
<annotation>
<celldesigner:alias>a110</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s53">
<annotation>
<celldesigner:alias>a82</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s54">
<annotation>
<celldesigner:alias>a83</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r22" reversible="false">
<annotation>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>s77,s1</celldesigner:baseReactants>
<celldesigner:baseProducts>s72</celldesigner:baseProducts>
<celldesigner:offset x="-175.0" y="-125.0"/>
<celldesigner:editPoints>0.33333333333333304,0.0 0.6666666666666663,-2.220446049250313E-16 0.3333333333333337,8.881784197001252E-16 0.6666666666666665,0.0 0.33333333333333304,2.220446049250313E-16 0.6666666666666665,4.440892098500626E-16 0.3333333333333335,0.33333333333333326</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s77">
<annotation>
<celldesigner:alias>a110</celldesigner:alias>
</annotation>
</speciesReference>
<speciesReference species="s1">
<annotation>
<celldesigner:alias>a10</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s72">
<annotation>
<celldesigner:alias>a103</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r23" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>s94</celldesigner:baseReactants>
<celldesigner:baseProducts>s95</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333304,0.0 0.666666666666667,0.0</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s94">
<annotation>
<celldesigner:alias>a133</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s95">
<annotation>
<celldesigner:alias>a134</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r24" reversible="false">
<annotation>
<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
<celldesigner:baseReactants>s93</celldesigner:baseReactants>
<celldesigner:baseProducts>s94</celldesigner:baseProducts>
<celldesigner:editPoints>0.3333333333333335,8.881784197001252E-16 0.6666666666666661,2.220446049250313E-15</celldesigner:editPoints>
</annotation>
<listOfReactants>
<speciesReference species="s93">
<annotation>
<celldesigner:alias>a132</celldesigner:alias>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference species="s94">
<annotation>
<celldesigner:alias>a133</celldesigner:alias>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction name="r25" reversible="false">
<annotation>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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