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<![CDATA[
The biosynthesis of thiamin (Vitamin B1). Thiamin is a cofactor for a small number of decarboxylating enzymes that are central to metabolism. 
Website=www.biocyc.org/Ecoli/Pathways/
free text=Voet and Voet  (textbook)  Biochemistry
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</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s21" initialAmount="0.0" name="ADP">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  ADP
Synonym:  Synonym not specified
Accession:  S04200
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ADP</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s22" initialAmount="0.0" name="tyrosine">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  tyrosine
Synonym:  Synonym not specified
Accession:  S04189
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>tyrosine</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s23" initialAmount="0.0" name="4-hydroxy-_br_benzyl alcohol">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  4-hydroxy-benzyl alcohol
Synonym:  Synonym not specified
Accession:  S04194
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>4-hydroxy-_br_benzyl alcohol</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s24" initialAmount="0.0" name="Hydroxyethyl_br_thiazole kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Hydroxyethylthiazole kinase
Synonym:  Synonym not specified
Accession:  P03172
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r5"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s25" initialAmount="0.0" name="4-Methyl-5-(hydroxyethyl)-_br_thiazole phosphate synthase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  4-Methyl-5-(hydroxyethyl)-thiazole phosphate synthase
Synonym:  Synonym not specified
Accession:  P03168
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r7"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s26" initialAmount="0.0" name="PP_sub_i">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  PPi
Synonym:  Synonym not specified
Accession:  S04204
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>PP_sub_i</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s3" initialAmount="0.0" name="5-phosphoribosyl-_br_5-aminoimidazole">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  PR-5-AI
Synonym:  Synonym not specified
Accession:  S04190
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>5-phosphoribosyl-_br_5-aminoimidazole</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s6" initialAmount="0.0" name="glyceraldehyde-3-phosphate">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  G-3-P
Synonym:  Synonym not specified
Accession:  S04197
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>glyceraldehyde-3-phosphate</celldesigner:name>
</celldesigner:speciesIdentity>
</annotation>
</species>
<species compartment="default" id="s14" initialAmount="0.0" name="HMP-phosphate kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Hydroxymethylpyrimidine phosphate kinase
Synonym:  Synonym not specified
Accession:  P03170
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r2"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
<species compartment="default" id="s13" initialAmount="0.0" name="HMP kinase">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<!--Notes by CellDesigner-->
<body>
Long Name:  Hydroxymethylpyrimidine kinase
Synonym:  Synonym not specified
Accession:  P03174
</body>
</html>
</notes>
<annotation>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p1</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="r1"/>
</celldesigner:listOfCatalyzedReactions>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
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<annotation>
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<celldesigner:baseProducts>s2</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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<celldesigner:reactantLink alias="a20" reactant="s20" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a21" product="s21" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
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</celldesigner:listOfModification>
</annotation>
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<annotation>
<celldesigner:alias>a1</celldesigner:alias>
</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
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<celldesigner:baseProducts>s4</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink alias="a22" reactant="s20" targetLineIndex="-1,1"/>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
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</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333335,2.220446049250313E-16 0.666666666666667,0.0</celldesigner:editPoints>
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</celldesigner:listOfModification>
</annotation>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
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<celldesigner:baseProducts>s10</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink alias="a32" product="s26" targetLineIndex="-1,1"/>
</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333337,1.1102230246251565E-16 0.6666666666666666,0.0</celldesigner:editPoints>
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</celldesigner:listOfModification>
</annotation>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
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<celldesigner:baseProducts>s11</celldesigner:baseProducts>
<celldesigner:editPoints>0.33333333333333215,0.0 0.666666666666667,0.0</celldesigner:editPoints>
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</celldesigner:listOfModification>
</annotation>
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<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction id="r5" reversible="false">
<annotation>
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<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
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</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.3333333333333335,0.0 0.666666666666667,-4.440892098500626E-16</celldesigner:editPoints>
<celldesigner:listOfModification>
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</celldesigner:listOfModification>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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<annotation>
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</annotation>
</speciesReference>
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<annotation>
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</annotation>
</modifierSpeciesReference>
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</reaction>
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<annotation>
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<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
<celldesigner:editPoints>0.33333333333333326,0.0 0.666666666666667,0.0</celldesigner:editPoints>
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<annotation>
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<annotation>
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<annotation>
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<annotation>
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</annotation>
</modifierSpeciesReference>
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</reaction>
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<annotation>
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<celldesigner:baseProducts>s9</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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<celldesigner:listOfProductLinks>
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</celldesigner:listOfProductLinks>
<celldesigner:editPoints>0.33333333333333326,-4.440892098500626E-16 0.6666666666666666,-8.881784197001252E-16</celldesigner:editPoints>
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</annotation>
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<annotation>
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<annotation>
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<annotation>
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</annotation>
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</reaction>
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<annotation>
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<celldesigner:baseProducts>s10</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
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</celldesigner:listOfProductLinks>
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<annotation>
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<annotation>
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<annotation>
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<annotation>
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<annotation>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
</listOfReactions>
</model>
</sbml>

